13-01527. Butofilolol [Archived]

Nomenclature

CAS number: 64552-17-6
1-[2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-5-fluorophenyl]-1-butanone; (±)-5-fluoro-2-(2-hydroxy-3-t-butylaminopropoxy)butyrophenone; (±)-2′-[3-(tert-butylamino)-2-hydroxypropoxy]-5′-fluorobutyrophenone; CM-6805.
C17H26FNO3; mol wt 311.39.
C 65.57%, H 8.42%, F 6.10%, N 4.50%, O 15.41%.

Description and references

β-Adrenergic blocker. Prepn: H. Demarne le Florence, DE 2528147; idem, US 4302601 (1976, 1981 both to C. M. Industries). Pharmacological study: G. G. Re et al., Boll. Soc. Ital. Biol. Sper. 56, 1264 (1980), C.A. 93, 197668y (1980). GC and HPLC determn in plasma and urine: J. P. Jeanniot et al., J. Chromatogr. 278, 301 (1983). Pharmacokinetics in humans: G. Houin et al., Int. J. Clin. Pharmacol. Res. 4, 175 (1984).

Chemical structure

Properties

Crystals from diisopropyl ether, mp 88-89°.

Derivative

Maleate.

Nomenclature

CAS number: 88606-96-6
Cafide (Labaz).
C17H26FNO3.C4H4O4; mol wt 427.46.
C 59.01%, H 7.07%, F 4.44%, N 3.28%, O 26.20%.

Therapeutic Category

Antihypertensive.

Keywords

β-Adrenergic Blocker; Antihypertensive; Aryloxypropanolamine Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.