13-02384. Clobenzepam [Archived]

Nomenclature

CAS number: 1159-93-9
7-Chloro-10-[2-(dimethylamino)ethyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one; 7-chloro-10-(2-dimethylaminoethyl)dibenzo[b,e][1,4]diazepin-11(10H)-one; 7-chloro-10-(β-dimethylaminoethyl)-10,11-dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine.
C17H18ClN3O; mol wt 315.80.
C 64.66%, H 5.75%, Cl 11.23%, N 13.31%, O 5.07%.

Description and references

Prepn: BE 611926 (1962 to Parke, Davis), C.A. 57, 13785a (1962); GB 961106; Schmutz, Hunziker, US 3419547 (1964, 1968 both to Wander). Pharmacology: H. Ackermann et al., Med. Exp. 6, 205 (1962); F. Hunziker et al., Arzneim.-Forsch. 13, 324 (1963).

Chemical structure

Properties

Colorless prisms from acetone-ether, mp 165-166°. uv max (alcohol): 230 nm (32,740).

Derivative

Hydrochloride.

Nomenclature

CAS number: 2726-03-6
Tarpan (Wander).
C17H18ClN3O.HCl; mol wt 352.26.
C 57.96%, H 5.44%, Cl 20.13%, N 11.93%, O 4.54%.

Properties

Colorless prisms from alcohol-ether, mp 225-233°. LD50 orally in mice: 330 mg/kg (Hunziker).

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Tricyclics; Other Tricyclics

Status

This monograph has been retired and is no longer subject to revision or update.