13-03604. Enciprazine [Archived]

Nomenclature

CAS number: 68576-86-3
4-(2-Methoxyphenyl)-α-[(3,4,5-trimethoxyphenoxy)methyl]-1-piperazineethanol; (±)-1-[3-(3,4,5-trimethoxyphenoxy)-2-hydroxypropyl]-4-(2-methoxyphenyl)piperazine.
C23H32N2O6; mol wt 432.51.
C 63.87%, H 7.46%, N 6.48%, O 22.20%.

Description and references

Prepn: A. Kleemann et al., DE 2814168; eidem, US 4335126 (1978, 1982 both to Degussa). Synthesis and pharmacology: J. Engel et al., J. Med. Chem. 33, 2976 (1990). Metabolism in rats: E. Benfenati et al., J. Pharm. Pharmacol. 39, 312 (1987). Clinical evaluation as anxiolytic: G. Scheibe et al., Arzneim.-Forsch. 40, 644 (1990); E. Schweizer et al., Psychopharmacol. Bull. 26, 215 (1990).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 68576-88-5
D-13112; Wy-48624.
C23H32N2O6.2HCl; mol wt 505.43.
C 54.66%, H 6.78%, N 5.54%, O 18.99%, Cl 14.03%.

Properties

Colorless crystals, mp 196-197°.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Arylpiperazines

Status

This monograph has been retired and is no longer subject to revision or update.