13-03768. Ethiazide [Archived]

Nomenclature

CAS number: 1824-58-4
6-Chloro-3-ethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-chloro-3-ethyl-3,4-dihydro-7-sulfamoylbenzo-1,2,4-thiadiazine 1,1-dioxide; 3-ethyl-3,4-dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide; acthiazidum.
C9H12ClN3O4S2; mol wt 325.79.
C 33.18%, H 3.71%, Cl 10.88%, N 12.90%, O 19.64%, S 19.68%.

Description and references

Prepn: Close et al., J. Am. Chem. Soc. 82, 1132 (1960); Topliss et al., J. Org. Chem. 26, 3842 (1961); GB 861367 (1961 to Ciba).

Chemical structure

Properties

Crystals from tetrahydrofuran + chloroform, mp 269-270°.
Component of Hypertane.

Therapeutic Category

Diuretic.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs

Status

This monograph has been retired and is no longer subject to revision or update.