13-04015. Fenpentadiol [Archived]

Nomenclature

CAS number: 15687-18-0
2-(4-Chlorophenyl)-4-methyl-2,4-pentanediol; 2-methyl-4-(p-chlorophenyl)-2,4-pentanediol; RD-292; Tredum (Hépatrol).
C12H17ClO2; mol wt 228.72.
C 63.02%, H 7.49%, Cl 15.50%, O 13.99%.

Description and references

Prepn: Valette, FR M1984 (1963 to Labs Albert Rolland), C.A. 60, 2828h (1964). Psychopharmacology: J. Ginet et al., Arzneim.-Forsch. 21, 1 (1971). Pharmacokinetics: Y. Dormand, J. C. Levron, Eur. J. Toxicol. 5, 43 (1972). Clinical evaluations: P. Mouren et al., Marseille Med. 106, 555 (1969); P. J. Parquet, Lille Med. 18, 836 (1973). Toxicity: H. Kriegel et al., Arzneim.-Forsch. 21, 9 (1971).

Chemical structure

Properties

Crystals from petr ether, mp 76.5°. uv max (0.1% in abs ethanol): 228 nm. LD50 in male, female mice, rats (mg/kg): 940, 995, 1200, 1250 orally (Kriegel).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant

Status

This monograph has been retired and is no longer subject to revision or update.