13-04722. Hexethal Sodium [Archived]
Nomenclature
CAS number: 144-00-3
5-Ethyl-5-hexyl-2,4,6(1H,3H,5H)-pyrimidinetrione monosodium salt; sodium 5-ethyl-5-hexylbarbiturate; Ortal Sodium; Hebaral. C12H19N2NaO3; mol wt 262.28.
C 54.95%, H 7.30%, N 10.68%, Na 8.77%, O 18.30%.
Description and references
Prepn: A. W. Dox, US 1624546. Anesthetic properties and toxicity data: C. M. Gruber, J. T. Brundage, J. Pharmacol. Exp. Ther. 60, 439 (1937).
Properties
White or slightly yellowish powder, mp 126°. Bitter taste. Very sol in water; sol in alcohol. Insol in ether, benzene. Aq solns are alkaline to litmus. Aq solns are unstable and dec on standing. Boiling evolves ammonia and causes precipitation of a solid. MLD i.p. in rats: 240-250 mg/kg (Gruber, Brundage).Note
This is a controlled substance (depressant): 21 CFR, 1308.13.Therapeutic Category
Sedative; hypnotic.
Therapeutic Category (Veterinary)
Sedative; hypnotic.Keywords
Sedative/Hypnotic; Barbituric Acid Derivatives
Status
This monograph has been retired and is no longer subject to revision or update.