13-05029. Iobenzamic Acid [Archived]

Nomenclature

CAS number: 3115-05-7
N-(3-Amino-2,4,6-triiodobenzoyl)-N-phenyl-β-alanine; β-[N-(3-amino-2,4,6-triiodobenzoyl)phenylamino]propionic acid; isobenzamic acid; Bilibyk (Byk Gulden); Osbil (Upjohn; M & B).
C16H13I3N2O3; mol wt 662.00.
C 29.03%, H 1.98%, I 57.51%, N 4.23%, O 7.25%.

Description and references

Prepn: GB 870321 (1961 to Oesterreichische Stickstoffwerke). Toxicity: Lindner et al., Arzneim.-Forsch. 11, 384 (1961).

Chemical structure

Properties

Crystals, mp 133-134.5°. Sol in acetone, dioxane, DMF; sparingly sol in cold ethanol, ether, benzene, toluene. Practically insol in water. LD50 orally in mice: 2.87 g/kg (Lindner).

Derivative

Methyl ester.
C17H15I3N2O3; mol wt 676.03.
C 30.20%, H 2.24%, I 56.32%, N 4.14%, O 7.10%.

Properties

Crystals, mp 156-157°.

Therapeutic Category

Diagnostic aid (radiopaque medium—cholecystographic).

Keywords

Diagnostic Aid (Radiopaque Medium)

Status

This monograph has been retired and is no longer subject to revision or update.