13-05089. Ipidacrine [Archived]

Nomenclature

CAS number: 62732-44-9
2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine; 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline; amiridin.
C12H16N2; mol wt 188.27.
C 76.55%, H 8.57%, N 14.88%.

Description and references

Cholinesterase inhibitor; structural analog of tacrine. Prepn: A. V. Upadysheva et al., Khim. Farm. Zh. 11, 40 (1977), C.A. 86, 189676q (1977). Prepn of the hydrochloride monohydrate: E. F. Levretskaya et al., DE 3231571; eidem, US 4550113 (1984, 1985 both to Sci. Res. Inst. Biol. Test. Chem. Compds). Neuropharmacology: T. Nabeshima et al., Eur. J. Pharmacol. 154, 263 (1988). Anticholinesterase activity: S. Shibanoki et al., Pharmacol. Biochem. Behav. 39, 499 (1991). Clinical evaluation in Alzheimer's disease: E. E. Bukatina et al., Neurosci. Behav. Physiol. 23, 83 (1993).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 90043-86-0; 118499-70-0 (monohydrate)
NIK-247.
C12H16N2.HCl; mol wt 224.73.
C 64.13%, H 7.62%, N 12.47%, Cl 15.78%.

Properties

Prepd as the monohydrate. White or slightly creamy, odorless powder. Readily sol in water, dil acids; slowly sol in ethanol. Practically insol in acetone, ether, chloroform.

Therapeutic Category

Nootropic.

Keywords

Cholinesterase Inhibitor; Nootropic

Status

This monograph has been retired and is no longer subject to revision or update.