13-05221. Isopromethazine [Archived]

Nomenclature

CAS number: 303-14-0
N,N,β-Trimethyl-10H-phenothiazine-10-ethanamine; 10-(2-dimethylamino-1-methylethyl)phenothiazine; 10-(2-dimethylaminoisopropyl)phenothiazine; isomethazine; Lilly 01526; RP-4460; Isophenergan; Fen-Bridal.
C17H20N2S; mol wt 284.42.
C 71.79%, H 7.09%, N 9.85%, S 11.27%.

Description and references

Prepn: Charpentier, Compt. Rend. 225, 306 (1947); Charpentier, Ducrot, ibid. 232, 415 (1951); Charpentier et al., ibid. 2232; Berg, Ashley, US 2607773 (1952 to Rhne-Poulenc); Edge, Wragg, J. Pharm. Pharmacol. 5, 279 (1953).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

Diprazin.
C17H20N2S.HCl; mol wt 320.88.
C 63.63%, H 6.60%, N 8.73%, S 9.99%, Cl 11.05%.

Properties

Crystals, mp 193-194°. More sol than promethazine.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Tricyclics; Phenothiazines

Status

This monograph has been retired and is no longer subject to revision or update.