13-05323. 11-Ketoprogesterone [Archived]

Nomenclature

CAS number: 516-15-4
Pregn-4-ene-3,11,20-trione; 11-oxoprogesterone; U-1258; Ketogestin (Upjohn).
C21H28O3; mol wt 328.45.
C 76.79%, H 8.59%, O 14.61%.

Description and references

Prepn: Reichstein, Fuchs, Helv. Chim. Acta 23, 688 (1940); from 11α-hydroxyprogesterone: Whiting, Schneider, US 3019238 (1962 to Upjohn).

Chemical structure

Properties

Crystals, mp 171.5-173°. [α]D25 +270° (chloroform). Practically insol in water. Sol in acetone, chloroform.

Therapeutic Category (Veterinary)

Has been used in ketosis.

Status

This monograph has been retired and is no longer subject to revision or update.