13-05346. Lachesine [Archived]

Nomenclature

CAS number: 1164-38-1
N-Ethyl-2-[(hydroxydiphenylacetyl)oxy]-N,N-dimethylethanaminium chloride; ethyl(2-hydroxyethyl)dimethylammonium chloride benzilate; E-3.
C20H26ClNO3; mol wt 363.88.
C 66.01%, H 7.20%, Cl 9.74%, N 3.85%, O 13.19%.

Description and references

Prepn: Ford-Moore, Ing, J. Chem. Soc. 1947, 55. Pharmacology: H. R. Ing et al., J. Pharmacol. Exp. Ther. 85, 85 (1945). Muscarinic receptor agonist: F. Roberts, R. P. Stephenson, Br. J. Pharmacol. 57, 395 (1976); D. A. Brown, S. Fatherazi, ibid. 59, 500P (1977); N. J. M. Birdsall et al., Mol. Pharmacol. 14, 723 (1978).

Chemical structure

Properties

Crystals from ethanol + acetone, mp 213°. LD50 in mice (mg/20 g): 0.8 i.p.; 3.2 s.c.; 20.0 orally (Ing).

Status

This monograph has been retired and is no longer subject to revision or update.