13-06006. Methioprim [Archived]

Nomenclature

CAS number: 588-36-3
4-Amino-2-methylthio-5-pyrimidinemethanol; 4-amino-2-methylmercapto-5-pyrimidinemethanol; 4-amino-5-hydroxymethyl-2-methylthiopyrimidine.
C6H9N3OS; mol wt 171.22.
C 42.09%, H 5.30%, N 24.54%, O 9.34%, S 18.73%.

Description and references

Synthesis starting with ethyl ethoxyethylenecyanoacetate: Ulbricht, Price, J. Org. Chem. 21, 567 (1956).

Chemical structure

Properties

Needle-like prisms from benzene, mp 126-127°.

Use

Tumor antagonist in mice.

Status

This monograph has been retired and is no longer subject to revision or update.