13-06029. Methoxypromazine [Archived]

Nomenclature

CAS number: 61-01-8
2-Methoxy-N,N-dimethyl-10H-phenothiazine-10-propanamine; 10-(3-dimethylaminopropyl)-2-methoxyphenothiazine; 3-methoxy-10-(3′-dimethylaminopropyl)phenothiazine; 2-methoxy-10-(3′-dimethylaminopropyl)phenothiazine; methopromazine; RP-4632.
C18H22N2OS; mol wt 314.45.
C 68.75%, H 7.05%, N 8.91%, O 5.09%, S 10.20%.

Description and references

Prepn: Charpentier et al., Compt. Rend. 235, 59 (1952); R. M. Jacob, J. G. Robert, US 2785160 (1957 to Rhone-Poulenc).

Chemical structure

Properties

Crystals, mp 44-48°.

Derivative

Maleate.

Nomenclature

CAS number: 3403-42-7
Mopazine; Tentone; Vetomazin.
C18H22N2OS.C4H4O4; mol wt 430.52.
C 61.38%, H 6.09%, N 6.51%, O 18.58%, S 7.45%.

Properties

Crystals, mp 141-145°. Should be protected from light during storage. Soly at 25° (g/100 ml) in water: 0.3; in methanol: 4; in chloroform: 12.5; in dimethylformamide: 100. Very slightly sol in ethanol, benzene. Practically insol in ether. pH of satd aq soln about 5.

Derivative

Oxalate.
C18H22N2OS.C2H2O4; mol wt 404.48.
C 59.39%, H 5.98%, N 6.93%, O 19.78%, S 7.93%.

Properties

Crystals, dec 178-179°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines

Status

This monograph has been retired and is no longer subject to revision or update.