13-06546. Nicomol [Archived]

Nomenclature

CAS number: 27959-26-8
3-Pyridinecarboxylic acid (2-hydroxy-1,3-cyclohexanediylidene)tetrakis(methylene) ester; nicotinic acid 1,1,3,3-tetraester with 2-hydroxy-1,1,3,3-cyclohexanetetramethanol; 2-hydroxycyclohexane-1,1,3,3-tetramethanol tetraester with nicotinic acid; tetranicotinic acid 2-hydroxycyclohexa-1,1,3,3-tetramethyl ester; 2,2,6,6-tetrakis(hydroxymethyl)-1-cyclohexanol 2,2,6,6-tetranicotinate; nicotinic acid 2-hydroxy-1,3-cyclohexanediylidenetetrakismethylene ester; 2,2,6,6-tetrakis(nicotinoyloxymethyl)cyclohexanol; K-31 (Kyorin); Cholexamin (Kyorin).
C34H32N4O9; mol wt 640.64.
C 63.74%, H 5.03%, N 8.75%, O 22.48%.

Description and references

Prepn: BE 658422 corresp to Irikura et al., US 3299077 (1965 and 1967 to Kyorin). Hypocholesterolemic action studies: Aso et al., J. Atheroscler. Res. 10, 391 (1969). Acute toxicity data: T. Sugawara et al., Oyo Yakuri 14, 741 (1977), C.A. 88, 131005v (1977). Review: Jpn. Med. Gaz. 8(8), 9 (1971).

Chemical structure

Properties

Crystals from dilute acetic acid, mp 177-180°. Practically odorless and tasteless. One gram is sol in 3 ml 1N HCl and 10 ml chloroform. Slightly sol in water, ethanol and ether. LD50 in mice, male and female rats (g/kg): >10, 15, <10 orally; >5, >2.5, >2.5 i.p. (Sugawara).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Nicotinic Acid Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.