13-06786. Octaverine [Archived]

Nomenclature

CAS number: 549-68-8
6,7-Dimethoxy-1-(3,4,5-triethoxyphenyl)isoquinoline; 1-(3,4,5-triethoxyphenyl)-6,7-dimethoxyisoquinoline; oktaverine.
C23H27NO5; mol wt 397.46.
C 69.50%, H 6.85%, N 3.52%, O 20.13%.

Description and references

Prepd by cyclodehydration and subsequent dehydrogenation of N-(3,4,5-triethoxybenzoyl)homoveratrylamine: FR 760825 (1934 to Asta Chemische Fabrik); cf. Goldberg, Shapero, J. Pharm. Pharmacol. 6, 171 (1954).

Chemical structure

Properties

Free base. Insol in water.

Derivative

Hydrochloride.
C23H27NO5.HCl; mol wt 433.93.
C 63.66%, H 6.50%, N 3.23%, O 18.44%, Cl 8.17%.

Properties

Crystals, mp 199-200°. Sparingly sol in water (1:500). Aq solns are acid to litmus.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic

Status

This monograph has been retired and is no longer subject to revision or update.