13-07297. Phenbutamide [Archived]

Nomenclature

CAS number: 3149-00-6
N-[(Butylamino)carbonyl]benzenesulfonamide; 1-butyl-3-(phenylsulfonyl)urea; N-benzenesulfonyl-N′-butylurea; fenbutamide; AL-132; R-131; Diaperos (Merieux); Ipoglon (Diana).
C11H16N2O3S; mol wt 256.32.
C 51.54%, H 6.29%, N 10.93%, O 18.73%, S 12.51%.
C6H5SO2NHCONHC4H9.

Description and references

Prepn: GB 808071 (1959 to Hoechst), C.A. 53, 14056c (1959); Hokfelt, Joenssen, J. Med. Pharm. Chem. 5, 231 (1962); Brzozowaki, Rocz. Chem. 43, 1761 (1969). Activity studies: Tonse et al., Nature 193, 891 (1962); Khurana et al., Indian J. Med. Res. 55, 1084 (1967).

Properties

Crystals, mp 130-132°.

Therapeutic Category

Antidiabetic.

Keywords

Antidiabetic; Sulfonylurea Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.