13-08223. Reposal [Archived]

Nomenclature

CAS number: 3625-25-0
5-Bicyclo[3.2.1]oct-2-en-3-yl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-bicyclo[3.2.1]oct-2-en-3-yl-5-ethylbarbituric acid; 5-ethyl-5-(bicyclo[3.2.1]octenyl)barbituric acid; WT-161; Reposamal.
C14H18N2O3; mol wt 262.30.
C 64.11%, H 6.92%, N 10.68%, O 18.30%.

Description and references

Prepn: Taub, US 2808408 (1956 to Calanda Stiftung). Metabolism: Nielsen, Tarding, Acta Pharmacol. Toxicol. 26, 521 (1968). Toxicity: Frey, Arzneim.-Forsch. 12, 389 (1962).

Chemical structure

Properties

Needles from isopropanol, mp 213°. pKa 7.4-7.5. LD50 i.p. in mice: 175 mg/kg (Frey).

Note

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Sedative; hypnotic.

Keywords

Sedative/Hypnotic; Barbituric Acid Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.