13-08805. Sozoiodolic Acid [Archived]

Nomenclature

CAS number: 554-71-2
4-Hydroxy-3,5-diiodobenzenesulfonic acid; 2,6-diiodophenol-4-sulfonic acid; Optojod.
C6H4I2O4S; mol wt 425.97.
C 16.92%, H 0.95%, I 59.58%, O 15.02%, S 7.53%.

Description and references

Made by iodizing potassium p-phenolsulfonic acid by means of ICl, or by KI and KIO3. Prepn of salts: Rupp, Herman, Arch. Pharm. 254, 488 (1916).

Chemical structure

Derivative

Trihydrate.

Nomenclature

CAS number: 6160-10-7

Properties

White, almost odorless needles, becoming anhydr at 100°. mp 120° when anhydr; dec at 190°. Freely sol in water, alcohol, ether, glycerol.

Derivative

Mercury deriv.

Nomenclature

CAS number: 515-43-5
Sozoiodole-mercury.
C6H2HgI2O4S; mol wt 624.54.
C 11.54%, H 0.32%, Hg 32.12%, I 40.64%, O 10.25%, S 5.13%.

Properties

Fine, orange-yellow powder. Poisonous! Practically insol in water, alcohol, ether, glycerol. Sol in NaCl or KI soln.

Derivative

Sodium salt dihydrate.

Nomenclature

CAS number: 6160-08-3
Sozoiodole-sodium; Dijozol (Trommsdorff).
C6H3I2NaO4S.2H2O; mol wt 483.98.
C 14.89%, H 1.46%, I 52.44%, Na 4.75%, O 19.83%, S 6.63%.

Properties

Crystals. Sol in water, alcohol, glycerol. Practically insol in ether.

Derivative

Zinc salt hexahydrate.

Nomenclature

CAS number: 6160-09-4
Sozoiodole-zinc.
C12H6I4O8S2Zn.6H2O; mol wt 1023.42.
C 14.08%, H 1.77%, I 49.60%, O 21.89%, S 6.27%, Zn 6.39%.

Properties

Needles, sol in water, alc, glycerol. Practically insol in ether.

Use

In a test for albumin.

Therapeutic Category

Diagnostic aid (radiopaque medium in retrograde pyelography). Hg deriv formerly in syphilis.

Keywords

Diagnostic Aid (Radiopaque Medium)

Sozoiodole-mercury: Antisyphilitic

Status

This monograph has been retired and is no longer subject to revision or update.