13-09097. Suriclone [Archived]

Nomenclature

CAS number: 53813-83-5
4-Methyl-1-piperazinecarboxylic acid 6-(7-chloro-1,8-naphthyridin-2-yl)-2,3,6,7-tetrahydro-7-oxo-5H-1,4-dithiino[2,3-c]pyrrol-5-yl ester; 6-(7-chloro-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole; RP-31264; Suril (RPR).
C20H20ClN5O3S2; mol wt 477.99.
C 50.26%, H 4.22%, Cl 7.42%, N 14.65%, O 10.04%, S 13.42%.

Description and references

Cyclopyrrolone derivative; structural analog of zopiclone. Prepn: C. Jeanmart et al., DE 2360362; eidem, US 3948917 (1974, 1976 both to Rhone-Poulenc). Benzodiazepine receptor binding studies: J.-C. Blanchard, L. Julou, J. Neurochem. 40, 601 (1983); R. R. Trifiletti, S. H. Snyder, Mol. Pharmacol. 26, 458 (1984); J. L. Zundel et al., Life Sci. 36, 2247 (1985). Pharmacology: L. Julou et al., Pharmacol. Biochem. Behav. 23, 653 (1985). Clinical evaluation as an anxiolytic: Y. D. Lapierre, K. L. Oyewumi, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 7, 805 (1983); W. E. Falk et al., Psychopharmacol. Bull. 23, 134 (1987).

Chemical structure

Properties

Crystals from acetonitrile, mp 280°.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic

Status

This monograph has been retired and is no longer subject to revision or update.