13-09162. Tasosartan [Archived]

Nomenclature

CAS number: 145733-36-4
5,8-Dihydro-2,4-dimethyl-8-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]pyrido[2,3-d]pyrimidin-7(6H)-one; ANA-756; Verdia (Am. Home).
C23H21N7O; mol wt 411.46.
C 67.14%, H 5.14%, N 23.83%, O 3.89%.

Description and references

Selective angiotensin II type 1 (AII1)-receptor antagonist. Prepn: J. W. Ellingboe et al., US 5149699 (1992 to Am. Home); idem et al., J. Med. Chem. 37, 542 (1994). Clinical tolerability in patients with essential hypertension: S. Oparil et al., Curr. Ther. Res. 58, 930 (1997); and efficacy: J. M. Neutel et al., Am. Heart J. 137, 118 (1999).

Chemical structure

Properties

White crystals from ethanol, mp 197-199°.

Therapeutic Category

Antihypertensive.

Keywords

Angiotensin II Receptor Antagonist; Antihypertensive; Biphenyltetrazole Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.