13-09197. Telenzepine [Archived]

Nomenclature

CAS number: 80880-90-6
4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinylacetyl)]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one.
C19H22N4O2S; mol wt 370.47.
C 61.60%, H 5.99%, N 15.12%, O 8.64%, S 8.66%.

Description and references

Gastric secretion inhibitor; selective muscarinic M1-receptor antagonist. Prepn: V. Figala et al., EP 35519; G. Rainer, US 4381301 (1981, 1983 both to Byk-Gulden). Pharmacology: M. Eltze et al., Eur. J. Pharmacol. 112, 211 (1985). GC-MS determn in serum: E. Sturm, A. Junker, J. Chromatogr. 430, 43 (1988). Clinical pharmacology: W. Londong et al., Gut 28, 888 (1987); R.W. Stockbrügger et al., Z. Gastroenterol. 26, 297 (1988). Comparative clinical trial with ranitidine: B. Simon et al., ibid. 28, 90 (1990).

Chemical structure

Properties

Crystals from ethanol, mp 263-264°.

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative; Gastric Secretion Inhibitor; Antimuscarinic

Status

This monograph has been retired and is no longer subject to revision or update.