13-09243. Terodiline [Archived]

Nomenclature

CAS number: 15793-40-5
N-(1,1-Dimethylethyl)-α-methyl-γ-phenylbenzenepropanamine; N-tert-butyl-1-methyl-3,3-diphenylpropylamine; N-(1-methyl-3,3-diphenylpropyl)-tert-butylamine; 4,4-diphenyl-2-(tert-butylamino)butane.
C20H27N; mol wt 281.44.
C 85.35%, H 9.67%, N 4.98%.

Description and references

Calcium antagonist with anticholinergic and vasodilatory activity. Prepn and use in treatment of angina: GB 923942; S. Carlsson, US 3371014 (1963, 1968 both to AB Recip). Pharmacokinetics: B. Karlen et al., Eur. J. Clin. Pharmacol. 23, 267 (1982). Series of articles on pharmacology and clinical efficacy in urinary frequency and motor urge incontinence: Scand. J. Urol. Nephrol. Suppl. 87, 1-61 (1984). Clinical trial in urinary incontinence: U. Ulmsten et al., Am. J. Obstet. Gynecol. 153, 619 (1985).

Chemical structure

Properties

Yellow liquid, bp1.0 130-132°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 7082-21-5
Mictrol (Pharmacia).
C20H27N.HCl; mol wt 317.90.
C 75.56%, H 8.88%, N 4.41%, Cl 11.15%.

Properties

Crystals from water, mp 178-180°. Sol in ethanol. Slightly sol in ether.

Therapeutic Category

Antianginal. In treatment of urinary incontinence.

Keywords

Antianginal; Calcium Channel Blocker; Arylalkylamines

Status

This monograph has been retired and is no longer subject to revision or update.