13-09771. Trimazosin [Archived]

Nomenclature

CAS number: 35795-16-5
4-(4-Amino-6,7,8-trimethoxy-2-quinazolinyl)-1-piperazinecarboxylic acid 2-hydroxy-2-methylpropyl ester.
C20H29N5O6; mol wt 435.47.
C 55.16%, H 6.71%, N 16.08%, O 22.04%.

Description and references

Prepn: H. J. Hess, DE 2120495 corresp to US 3669968 (1971, 1972 both to Pfizer). Pharmacological study in rats: J. P. Buyniski et al., Clin. Exp. Hypertens. 2, 1039 (1980), C.A. 94, 76779x (1981). Cardiocirculatory effects in congestive heart failure: N. A. Awan et al., Am. J. Cardiol. 44, 126 (1979). Long-term therapeutic use: K. T. Weber et al., N. Engl. J. Med. 303, 242 (1980).

Chemical structure

Properties

White cryst from chloroform/diisopropyl ether, mp 158-159°.

Derivative

Hydrochloride monohydrate.

Nomenclature

CAS number: 53746-46-6
CP-19106-1; Supres (Pfizer).
C20H29N5O6.HCl.H2O; mol wt 489.95.
C 49.03%, H 6.58%, N 14.29%, O 22.86%, Cl 7.24%.

Properties

White cryst, mp 166-169° (dec).

Therapeutic Category

Antihypertensive.

Keywords

α-Adrenergic Blocker; Antihypertensive; Quinazoline Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.