13-09808. Triparanol [Archived]

Nomenclature

CAS number: 78-41-1
4-Chloro-α-[4-[2-(diethylamino)ethoxy]phenyl]-α-(4-methylphenyl)benzeneethanol; 1-[p-(2-diethylaminoethoxy)phenyl]-1-(p-tolyl)-2-(p-chlorophenyl)ethanol; 2-(p-chlorophenyl)-1-[p-(2-diethylaminoethoxy)phenyl]-1-(p-tolyl)ethanol; MER-29; Trianel; Hipocolestina; Triparin; Acosterina; Metasclene; Diticyl; Drenaren; Clotrox; Tropalin; Trikosterol; Valip; Verdiana; Metasqualene; Sclane.
C27H32ClNO2; mol wt 438.00.
C 74.04%, H 7.36%, Cl 8.09%, N 3.20%, O 7.31%.

Description and references

Prepn: Allen, Palopoli et al., US 2914562 (1959 to Wm. S. Merrell).

Chemical structure

Properties

Crystals, mp 102-104°. Sol in alcohol; slightly sol in olive oil; practically insol in water.

Caution

Withdrawn from market because of association with formation of irreversible cataracts; see Laughlin, Carey, J. Am. Med. Assoc. 181, 339 (1962).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic

Status

This monograph has been retired and is no longer subject to revision or update.