Appendix I E. Reference Materials
Where the letters BPCRS appear after the name of a substance in a test or assay, the British Pharmacopoeia Chemical Reference Substance is to be used. A comprehensive and up-to-date list of British Pharmacopoeia Chemical Reference Substances, together with terms of trade and supply, is available on our website at www.pharmacopoeia.com. The substances are obtainable from the BPCRS Sales Office, MHRA, 5th Floor, 151 Buckingham Palace Road, London SW1W 9SZ, United Kingdom (telephone +44 (0)20 3080 6561, e-mail: bpcom@mhra.gov.uk, website www.pharmacopoeia.com).
In addition to BPCRS, monographs of the British Pharmacopoeia may also refer to reference substances available from other suppliers. These are denoted by the letters CRS.
Where the letters CRS or EPCRS appear, the chemical reference substance issued by the European Pharmacopoeia Commission is to be used; where the letters BRP or EPBRP appear, the Biological Reference Preparation issued by the European Pharmacopoeia Commission is to be used; where the letters HRS or EPHRS appear, the herbal reference substance issued by the European Pharmacopoeia Commission is to be used. The substances, as well as European Pharmacopoeia infrared reference spectra, are obtainable from the Council of Europe, European Directorate for the Quality of Medicines & HealthCare, CRS Sales Team, 7 allée Kastner, CS 30026, F-67081, Strasbourg Cedex, France (facsimile +33 (0)3 88 41 27 71, e-mail: crs@pheur.org, website www.edqm.eu).
Other sources of specific reference substances are shown below.
Astragaloside I CRS, Astragaloside II CRS, Astragaloside IV CRS, azadirachtin A CRS, bacopaside I CRS, bacopaside II CRS, bacoside A CRS, Paeonol CRS, Rosmarinic acid CRS, salannin CRS, Salvianolic Acid B CRS, Tanshinone IIA CRS, Withaferin A CRS, Withanolide A CRS, Withanolide B CRS, Z-Ligustilide CRS may be obtained from Chromadex Inc. through LGC Standards, Queen’s Road, Teddington, TW11 0LY, United Kingdom (telephone +44 (0)20 8943 8480, facsimile +44 (0)20 8943 7554, e-mail: uksales@lgcstandards.com).
Opacity, Standard Preparation of The Standard Preparation is the 5th International Reference Preparation, established in 1975, and consists of a rod of plastic simulating the optical properties of a bacterial suspension (10 Units of opacity). It may be obtained from the National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom (telephone +44 (0)1707 641000, e-mail: enquiries@nibsc.org).
Piperonyl Butoxide CRS may be obtained from LGC Standards, Queen’s Road, Teddington, TW11 0LY, United Kingdom (telephone +44 (0)20 8943 8480, facsimile +44 (0)20 8943 7554, e-mail: uksales@lgcstandards.com).