Chewable Calcium Carbonate Tablets
Definition
Chewable Calcium Carbonate Tablets contain Calcium Carbonate. They may be flavoured.
Content of calcium, Ca
95.0 to 105.0% of the stated amount.
Identification
Tests
Disintegration
The requirement for Disintegration does not apply to Chewable Calcium Carbonate Tablets.
Assay
Weigh and powder 20 tablets. To a quantity of the powder containing the equivalent of 0.25 g of calcium add 50 mL of water and 5 mL of hydrochloric acid. Heat the dispersion gently to boiling and continue to boil for about 2 minutes. Allow to cool, add sufficient water to produce 250 mL and filter, if necessary. To 50 mL of this solution add 50 mL of 0.05m disodium edetate VS. Neutralise the solution using 2m sodium hydroxide and add 10 mL of ammonia buffer pH 10.9 and 50 mL of water. Titrate the excess of disodium edetate with 0.05m zinc chloride VS using mordant black II solution as indicator. Each mL of 0.05m disodium edetate VS is equivalent to 2.004 mg of Ca.
Storage
Chewable Calcium Carbonate Tablets should be protected from moisture.
Labelling
The quantity of active ingredient is stated in terms of the equivalent amount of calcium.