Effervescent Potassium Chloride Tablets

Definition

Effervescent Potassium Chloride Tablets contain potassium ions and chloride ions in an effervescent basis. The proportion of chloride ions to potassium ions may vary, but the stated molar proportion of chloride ions should be not less than 66% of that of potassium ions.

Content of potassium ions, K⁺

95.0 to 105.0% of the stated amount.

Content of chloride ions, Cl^-

95.0 to 105.0% of the stated amount.

Identification

Tests

Disintegration

The requirement for Disintegration does not apply to Effervescent Potassium Chloride Tablets.

Solution

One tablet dissolves in 100 mL of water at 20° with brisk effervescence in not more than 3 minutes. The resulting solution is not more than faintly opalescent.

Assay

Weigh and powder 20 tablets.

For potassium ions

Dissolve a quantity of the powder containing 35 mg of potassium ions in sufficient water to produce 500 mL. Dilute 5 mL of the resulting solution to 100 mL with a 0.6% w/v solution of strontium chloride and determine the content of potassium by Method I for atomic emission spectrophotometry, Appendix II D, measuring at 767 nm and using potassium standard solution (600 ppm K), suitably diluted with a 0.6% w/v solution of strontium chloride, to prepare the standard solutions.

For chloride ions

Dissolve a quantity of the powder containing 0.12 g of chloride ions in water, dilute to 50 mL with water and titrate with 0.1m silver nitrate VS using potassium chromate solution as indicator. Each mL of 0.1m silver nitrate VS is equivalent to 3.545 mg of Cl.

Labelling

The label states the content of potassium ions and the content of chloride ions in terms of the weight and the number of millimoles of ion present in each tablet.

When Effervescent Potassium Chloride Tablets are prescribed or demanded, the amount of potassium required in each tablet must be specified.