Ethosuximide Capsules
Action and use
Antiepileptic.
Definition
Ethosuximide Capsules contain Ethosuximide.
Content of ethosuximide, C7H11NO2
95.0 to 105.0% of the stated amount.
Identification
Assay
Weigh 20 capsules. Open the capsules carefully without loss of shell material, express as much of the contents as possible and reserve the expressed material. Wash the shells with ether, discard the washings, allow the shells to stand at room temperature until the ether has evaporated and weigh. The difference between the weights represents the weight of the total contents. Dissolve a quantity of the contents containing 0.2 g of Ethosuximide in 30 mL of dimethylformamide and carry out Method II for non-aqueous titration, Appendix VIII A, using magneson solution as indicator and 0.1m tetrabutylammonium hydroxide VS as titrant. Each mL of 0.1m tetrabutylammonium hydroxide VS is equivalent to 14.12 mg of C7H11NO2.