ID

DB00185|APRD00224||

名称

Cevimeline

描述

Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.

cas号

107233-08-9

唯一标识码

K9V0CDQ56E

状态

solid

组

approved,

指示

For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.

药效学

Cevimeline is a cholinergic agonist which binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can increase secretion of exocrine glands, such as salivary and sweat glands and increase tone of the smooth muscle in the gastrointestinal and urinary tracts.

作用机制

Muscarinic agonists such as cevimeline bind and activate the muscarinic M1 and M3 receptors. The M1 receptors are common in secretory glands (exocrine glands such as salivary and sweat glands), and their activation results in an increase in secretion from the secretory glands. The M3 receptors are found on smooth muscles and in many glands which help to stimulate secretion in salivary glands, and their activation generally results in smooth muscle contraction and increased glandular secretions. Therefore, as saliva excretion is increased, the symptoms of dry mouth are relieved.

毒性

代谢

Primarily hepatic, isozymes CYP2D6 and CYP3A4 are responsible for the metabolism of cevimeline. Approximately 44.5% of the drug is converted to cis and trans-sulfoxide, 22.3% to glucuronic acid conjugate, and 4% to N-oxide of cevimeline. Approximately 8% of the trans-sulfoxide metabolite is then converted into the corresponding glucuronic acid conjugate.

吸收

Rapidly absorbed with peak concentration after 1.5 to 2 hours

半衰期

5 ± 1 hours

分类

description:This compound belongs to the class of organic compounds known as azaspirodecane derivatives. These are organic compounds containing a spirodecane moiety with at least one nitrogen atom.
direct-parent:Azaspirodecane derivatives
kingdom:Organic compounds
superclass:Organoheterocyclic compounds
class:Azaspirodecane derivatives
subclass:
alternative-parent:Azacyclic compounds
alternative-parent:Hydrocarbon derivatives
alternative-parent:Monothioacetals
alternative-parent:Organooxygen compounds
alternative-parent:Organopnictogen compounds
alternative-parent:Oxacyclic compounds
alternative-parent:Oxathiolanes
alternative-parent:Piperidines
alternative-parent:Quinuclidines
alternative-parent:Trialkylamines
substituent:Aliphatic heteropolycyclic compound
substituent:Amine
substituent:Azacycle
substituent:Azaspirodecane
substituent:Hydrocarbon derivative
substituent:Monothioacetal
substituent:Organic nitrogen compound
substituent:Organic oxygen compound
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound
substituent:Oxacycle
substituent:Oxathiolane
substituent:Piperidine
substituent:Quinuclidine
substituent:Tertiary aliphatic amine
substituent:Tertiary amine

消除途径

After 24 hours, 84% of a 30 mg dose of cevimeline was excreted in urine.

种类

Autonomic Agents
D001337
Cholinergic Agents
D018678
Cholinergic Agonists
D018679
Cholinergic Receptor Agonist

Cytochrome P-450 CYP2D6 Substrates

Cytochrome P-450 CYP3A Substrates

Cytochrome P-450 CYP3A4 Substrates

Cytochrome P-450 Substrates

Drugs that are Mainly Renally Excreted

Muscarinic Agonists
D018721
Nervous System
D009420
Neurotransmitter Agents
D018377
Parasympathomimetics
D010277
Peripheral Nervous System Agents
D018373
Sulfur Compounds
D013457

盐类

DBSALT000805Cevimeline hydrochlorideP81Q6V85NP153504-70-2ZSTLCHCDLIUXJE-ZGBAEQJLSA-N489.56488.1700908

蛋白质结合

< 20%

清除

同义词

language:english; code:; name;2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine
language:spanish; code:inn; name;Cevimelina
language:french; code:inn; name;Cévimèline
language:english; code:inn; name;Cevimeline
language:latin; code:inn; name;Cevimelinum

国际品牌

Saligren

配送量

* 6 L/kg

产品

name:Cevimeline
labeller:Sun Pharmaceutical Industries, Inc.
ndc-id:
ndc-product-code:63304-479
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-03-10
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:NDA020989
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Novel Laboratories, Inc.
ndc-id:
ndc-product-code:40032-999
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-12-30
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA204746
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Amerincan Health Packaging
ndc-id:
ndc-product-code:60687-117
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2015-03-31
ended-marketing-on:2018-11-30
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:NDA020989
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Rising Pharma Holdings, Inc.
ndc-id:
ndc-product-code:16571-657
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-06-17
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA203775
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Lupin Pharmaceuticals,Inc.
ndc-id:
ndc-product-code:43386-999
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-12-30
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA204746
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Hikma Pharmaceuticals USA Inc.
ndc-id:
ndc-product-code:0054-0334
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2013-07-08
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA091591
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Avera McKennan Hospital
ndc-id:
ndc-product-code:69189-0399
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2015-10-30
ended-marketing-on:2017-05-24
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA091591
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Apotex Corp.
ndc-id:
ndc-product-code:60505-3145
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2012-10-08
ended-marketing-on:2017-04-30
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA091260
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cevimeline Hydrochloride
labeller:Ingenus Pharmaceuticals Nj, Llc
ndc-id:
ndc-product-code:52682-500
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-06-17
ended-marketing-on:2014-06-17
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA203775
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Evoxac
labeller:Stat Rx USA
ndc-id:
ndc-product-code:16590-859
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2000-01-11
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:NDA020989
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Evoxac
labeller:Daiichi Sankyo, Inc.
ndc-id:
ndc-product-code:63395-201
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2000-01-12
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:NDA020989
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC

混合物

name:Evoxac
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline
name:Evoxac
ingredients:Cevimeline
name:Cevimeline
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline
name:Cevimeline Hydrochloride
ingredients:Cevimeline

包装者

name:Astellas Pharma Inc.
url:http://www.astellas.com
name:Daiichi Sankyo
url:http://www.daiichisankyo.com

生产者

generic:否; url:; name;Daiichi sankyo co ltd

价格

Evoxac 30 mg capsule
2.69(单位：USD）
capsule

受影响的生物体

Humans and other mammals

剂量

form:Capsule
route:Oral
strength:30 mg/1

atc代码

Other parasympathomimetics
PARASYMPATHOMIMETICS
OTHER NERVOUS SYSTEM DRUGS
NERVOUS SYSTEM

fda标签

//s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00185.pdf?1265922796

化学品安全技术说明书

专利

number:5340821
country:United States
approved:1994-08-23
expires:2013-07-07
pediatric-extension:否
number:4855290
country:United States
approved:1989-08-08
expires:2009-08-30
pediatric-extension:否

食物相互作用

药物相互作用

DB00187
The risk or severity of adverse effects can be increased when Esmolol is combined with Cevimeline.
DB00195
The risk or severity of adverse effects can be increased when Betaxolol is combined with Cevimeline.
DB00335
The risk or severity of adverse effects can be increased when Atenolol is combined with Cevimeline.
DB00866
The risk or severity of adverse effects can be increased when Alprenolol is combined with Cevimeline.
DB01295
The risk or severity of adverse effects can be increased when Bevantolol is combined with Cevimeline.
DB01297
The risk or severity of adverse effects can be increased when Practolol is combined with Cevimeline.
DB03322
The risk or severity of adverse effects can be increased when Dexpropranolol is combined with Cevimeline.
DB04846
The risk or severity of adverse effects can be increased when Celiprolol is combined with Cevimeline.
DB06726
The risk or severity of adverse effects can be increased when Bufuralol is combined with Cevimeline.
DB08807
The risk or severity of adverse effects can be increased when Bopindolol is combined with Cevimeline.
DB08808
The risk or severity of adverse effects can be increased when Bupranolol is combined with Cevimeline.
DB08952
The risk or severity of adverse effects can be increased when Indenolol is combined with Cevimeline.
DB09351
The risk or severity of adverse effects can be increased when Levobetaxolol is combined with Cevimeline.
DB11770
The risk or severity of adverse effects can be increased when Talinolol is combined with Cevimeline.
DB11785
The risk or severity of adverse effects can be increased when Anisodamine is combined with Cevimeline.
DB12752
The risk or severity of adverse effects can be increased when Bucindolol is combined with Cevimeline.
DB13443
The risk or severity of adverse effects can be increased when Esatenolol is combined with Cevimeline.
DB13508
The risk or severity of adverse effects can be increased when Cloranolol is combined with Cevimeline.
DB13530
The risk or severity of adverse effects can be increased when Mepindolol is combined with Cevimeline.
DB13757
The risk or severity of adverse effects can be increased when Epanolol is combined with Cevimeline.
DB13775
The risk or severity of adverse effects can be increased when Tertatolol is combined with Cevimeline.
DB00373
The risk or severity of adverse effects can be increased when Cevimeline is combined with Timolol.
DB00571
The risk or severity of adverse effects can be increased when Cevimeline is combined with Propranolol.
DB00612
The risk or severity of adverse effects can be increased when Cevimeline is combined with Bisoprolol.
DB00960
The risk or severity of adverse effects can be increased when Cevimeline is combined with Pindolol.
DB01203
The risk or severity of adverse effects can be increased when Cevimeline is combined with Nadolol.
DB01359
The risk or severity of adverse effects can be increased when Cevimeline is combined with Penbutolol.
DB09204
The risk or severity of adverse effects can be increased when Cevimeline is combined with Arotinolol.
DB01136
The risk or severity of adverse effects can be increased when Carvedilol is combined with Cevimeline.
DB04861
The risk or severity of adverse effects can be increased when Nebivolol is combined with Cevimeline.
DB12212
The risk or severity of adverse effects can be increased when Cevimeline is combined with Landiolol.
DB09271
Cevimeline may decrease the anticholinergic activities of Cimetropium.
DB00382
The risk or severity of adverse effects can be increased when Tacrine is combined with Cevimeline.
DB00391
The risk or severity of adverse effects can be increased when Sulpiride is combined with Cevimeline.
DB00392
The risk or severity of adverse effects can be increased when Profenamine is combined with Cevimeline.
DB00483
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Cevimeline.
DB00508
The risk or severity of adverse effects can be increased when Triflupromazine is combined with Cevimeline.
DB00527
The risk or severity of adverse effects can be increased when Cinchocaine is combined with Cevimeline.
DB00585
The risk or severity of adverse effects can be increased when Nizatidine is combined with Cevimeline.
DB00677
The risk or severity of adverse effects can be increased when Isoflurophate is combined with Cevimeline.
DB00711
The risk or severity of adverse effects can be increased when Diethylcarbamazine is combined with Cevimeline.
DB00721
The risk or severity of adverse effects can be increased when Procaine is combined with Cevimeline.
DB00888
The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Cevimeline.
DB00941
The risk or severity of adverse effects can be increased when Hexafluronium is combined with Cevimeline.
DB00944
The risk or severity of adverse effects can be increased when Demecarium is combined with Cevimeline.
DB00981
The risk or severity of adverse effects can be increased when Physostigmine is combined with Cevimeline.
DB01122
The risk or severity of adverse effects can be increased when Ambenonium is combined with Cevimeline.
DB01199
The risk or severity of adverse effects can be increased when Tubocurarine is combined with Cevimeline.
DB01245
The risk or severity of adverse effects can be increased when Decamethonium is combined with Cevimeline.
DB01337
The risk or severity of adverse effects can be increased when Pancuronium is combined with Cevimeline.
DB01338
The risk or severity of adverse effects can be increased when Pipecuronium is combined with Cevimeline.
DB01381
The risk or severity of adverse effects can be increased when Ginkgo biloba is combined with Cevimeline.
DB01400
The risk or severity of adverse effects can be increased when Neostigmine is combined with Cevimeline.
DB01408
The risk or severity of adverse effects can be increased when Bambuterol is combined with Cevimeline.
DB02365
The risk or severity of adverse effects can be increased when 1,10-Phenanthroline is combined with Cevimeline.
DB04864
The risk or severity of adverse effects can be increased when Huperzine A is combined with Cevimeline.
DB04892
The risk or severity of adverse effects can be increased when Phenserine is combined with Cevimeline.
DB05386
The risk or severity of adverse effects can be increased when Regramostim is combined with Cevimeline.
DB06692
The risk or severity of adverse effects can be increased when Aprotinin is combined with Cevimeline.
DB06756
The risk or severity of adverse effects can be increased when Glycine betaine is combined with Cevimeline.
DB11390
The risk or severity of adverse effects can be increased when Coumaphos is combined with Cevimeline.
DB11397
The risk or severity of adverse effects can be increased when Dichlorvos is combined with Cevimeline.
DB11412
The risk or severity of adverse effects can be increased when Fenthion is combined with Cevimeline.
DB11473
The risk or severity of adverse effects can be increased when Metrifonate is combined with Cevimeline.
DB12482
The risk or severity of adverse effects can be increased when Acotiamide is combined with Cevimeline.
DB13058
The risk or severity of adverse effects can be increased when Methanesulfonyl Fluoride is combined with Cevimeline.
DB13495
The risk or severity of adverse effects can be increased when Paraoxon is combined with Cevimeline.
DB13503
The risk or severity of adverse effects can be increased when Tyrothricin is combined with Cevimeline.
DB13668
The risk or severity of adverse effects can be increased when Ipidacrine is combined with Cevimeline.
DB13694
The risk or severity of adverse effects can be increased when Distigmine is combined with Cevimeline.
DB14031
The risk or severity of adverse effects can be increased when Tretamine is combined with Cevimeline.
DB15317
The risk or severity of adverse effects can be increased when Posiphen is combined with Cevimeline.
DB00545
The risk or severity of adverse effects can be increased when Pyridostigmine is combined with Cevimeline.
DB00989
The risk or severity of adverse effects can be increased when Rivastigmine is combined with Cevimeline.
DB02845
The risk or severity of adverse effects can be increased when Methylphosphinic Acid is combined with Cevimeline.
DB00082
The risk or severity of adverse effects can be increased when Pegvisomant is combined with Cevimeline.
DB00358
The risk or severity of adverse effects can be increased when Mefloquine is combined with Cevimeline.
DB04572
The risk or severity of adverse effects can be increased when Thiotepa is combined with Cevimeline.
DB06774
The risk or severity of adverse effects can be increased when Capsaicin is combined with Cevimeline.
DB00482
The metabolism of Cevimeline can be decreased when combined with Celecoxib.
DB00176
The metabolism of Cevimeline can be decreased when combined with Fluvoxamine.
DB00264
The metabolism of Metoprolol can be decreased when combined with Cevimeline.
DB00285
The metabolism of Venlafaxine can be decreased when combined with Cevimeline.
DB00349
The metabolism of Clobazam can be decreased when combined with Cevimeline.
DB00363
The metabolism of Clozapine can be decreased when combined with Cevimeline.
DB00476
The metabolism of Duloxetine can be decreased when combined with Cevimeline.
DB00477
The metabolism of Chlorpromazine can be decreased when combined with Cevimeline.
DB00501
The metabolism of Cimetidine can be decreased when combined with Cevimeline.
DB00608
The metabolism of Chloroquine can be decreased when combined with Cevimeline.
DB00622
The metabolism of Cevimeline can be decreased when combined with Nicardipine.
DB01087
The metabolism of Cevimeline can be decreased when combined with Primaquine.
DB02703
The metabolism of Cevimeline can be decreased when combined with Fusidic acid.
DB00705
The metabolism of Cevimeline can be decreased when combined with Delavirdine.
DB01026
The metabolism of Cevimeline can be decreased when combined with Ketoconazole.
DB04868
The metabolism of Cevimeline can be decreased when combined with Nilotinib.
DB00169
The metabolism of Cevimeline can be decreased when combined with Cholecalciferol.
DB00752
The metabolism of Cevimeline can be decreased when combined with Tranylcypromine.
DB01074
The metabolism of Cevimeline can be decreased when combined with Perhexiline.
DB01079
The metabolism of Cevimeline can be decreased when combined with Tegaserod.
DB05812
The metabolism of Cevimeline can be decreased when combined with Abiraterone.
DB06603
The metabolism of Cevimeline can be decreased when combined with Panobinostat.
DB06684
The metabolism of Cevimeline can be decreased when combined with Vilazodone.
DB06729
The metabolism of Cevimeline can be decreased when combined with Sulfaphenazole.
DB06819
The metabolism of Cevimeline can be decreased when combined with Phenylbutyric acid.
DB09238
The metabolism of Cevimeline can be decreased when combined with Manidipine.
DB09291
The metabolism of Cevimeline can be decreased when combined with Rolapitant.
DB11586
The metabolism of Cevimeline can be decreased when combined with Asunaprevir.
DB12332
The metabolism of Cevimeline can be decreased when combined with Rucaparib.
DB12693
The metabolism of Cevimeline can be decreased when combined with Ritanserin.
DB13174
The metabolism of Cevimeline can be decreased when combined with Rhein.
DB00468
The metabolism of Cevimeline can be decreased when combined with Quinine.
DB00857
The metabolism of Cevimeline can be decreased when combined with Terbinafine.
DB06708
The metabolism of Cevimeline can be decreased when combined with Lumefantrine.
DB00091
The metabolism of Cyclosporine can be decreased when combined with Cevimeline.
DB00342
The metabolism of Terfenadine can be decreased when combined with Cevimeline.
DB00458
The metabolism of Imipramine can be decreased when combined with Cevimeline.
DB00496
The metabolism of Darifenacin can be decreased when combined with Cevimeline.
DB00932
The metabolism of Tipranavir can be decreased when combined with Cevimeline.
DB01151
The metabolism of Desipramine can be decreased when combined with Cevimeline.
DB09167
The metabolism of Dosulepin can be decreased when combined with Cevimeline.
DB04871
The metabolism of Lorcaserin can be decreased when combined with Cevimeline.
DB08893
The metabolism of Mirabegron can be decreased when combined with Cevimeline.
DB15982
The metabolism of Cevimeline can be decreased when combined with Berotralstat.
DB00679
The metabolism of Cevimeline can be decreased when combined with Thioridazine.
DB00715
The metabolism of Cevimeline can be decreased when combined with Paroxetine.
DB01012
The metabolism of Cevimeline can be decreased when combined with Cinacalcet.
DB01156
The metabolism of Cevimeline can be decreased when combined with Bupropion.
DB01173
The metabolism of Cevimeline can be decreased when combined with Orphenadrine.
DB01182
The metabolism of Cevimeline can be decreased when combined with Propafenone.
DB01218
The metabolism of Cevimeline can be decreased when combined with Halofantrine.
DB01403
The metabolism of Cevimeline can be decreased when combined with Methotrimeprazine.
DB08909
The metabolism of Cevimeline can be decreased when combined with Glycerol phenylbutyrate.
DB00604
The metabolism of Cevimeline can be decreased when combined with Cisapride.
DB00908
The metabolism of Cevimeline can be decreased when combined with Quinidine.
DB06595
The metabolism of Cevimeline can be decreased when combined with Midostaurin.
DB11642
The serum concentration of Cevimeline can be decreased when it is combined with Pitolisant.
DB00159
Icosapent may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00229
Cefotiam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00244
Mesalazine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00267
Cefmenoxime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00274
Cefmetazole may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00282
Pamidronic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00300
Tenofovir disoproxil may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00328
Indomethacin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00369
Cidofovir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00384
Triamterene may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00430
Cefpiramide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00438
Ceftazidime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00447
Loracarbef may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00456
Cefalotin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00461
Nabumetone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00465
Ketorolac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00469
Tenoxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00493
Cefotaxime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00500
Tolmetin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00529
Foscarnet may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00533
Rofecoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00554
Piroxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00563
Methotrexate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00567
Cephalexin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00573
Fenoprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00577
Valaciclovir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00580
Valdecoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00586
Diclofenac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00605
Sulindac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00626
Bacitracin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00681
Amphotericin B may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00689
Cephaloglycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00712
Flurbiprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00718
Adefovir dipivoxil may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00738
Pentamidine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00742
Mannitol may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00749
Etodolac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00784
Mefenamic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00787
Acyclovir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00788
Naproxen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00795
Sulfasalazine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00812
Phenylbutazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00814
Meloxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00821
Carprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00833
Cefaclor may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00861
Diflunisal may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00903
Etacrynic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00923
Ceforanide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00936
Salicylic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00939
Meclofenamic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00945
Acetylsalicylic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00958
Carboplatin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00991
Oxaprozin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00999
Hydrochlorothiazide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01009
Ketoprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01014
Balsalazide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01050
Ibuprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01066
Cefditoren may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01111
Colistimethate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01112
Cefuroxime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01139
Cefapirin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01140
Cefadroxil may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01150
Cefprozil may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01212
Ceftriaxone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01250
Olsalazine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01283
Lumiracoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01326
Cefamandole may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01327
Cefazolin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01328
Cefonicid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01329
Cefoperazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01330
Cefotetan may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01331
Cefoxitin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01332
Ceftizoxime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01333
Cefradine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01397
Magnesium salicylate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01399
Salsalate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01401
Choline magnesium trisalicylate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01413
Cefepime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01414
Cefacetrile may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01415
Ceftibuten may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01416
Cefpodoxime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01419
Antrafenine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01424
Aminophenazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01435
Antipyrine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01600
Tiaprofenic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01628
Etoricoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB02247
Hydrolyzed Cephalothin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB03450
Cephalothin Group may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB03585
Oxyphenbutazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04570
Latamoxef may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04743
Nimesulide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04812
Benoxaprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04817
Metamizole may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04828
Zomepirac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04918
Ceftobiprole may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB05095
Cimicoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB06590
Ceftaroline fosamil may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB06725
Lornoxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB06736
Aceclofenac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB06737
Zaltoprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB07402
Azapropazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08439
Parecoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08797
Salicylamide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08940
Kebuzone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08942
Isoxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08951
Indoprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08955
Ibuproxam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08976
Floctafenine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08981
Fenbufen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08984
Etofenamate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08991
Epirizole may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09008
Cefaloridine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09062
Cefminox may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09084
Benzydamine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09213
Dexibuprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09214
Dexketoprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09215
Droxicam may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09216
Tolfenamic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09217
Firocoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09218
Clonixin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09285
Morniflumate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09288
Propacetamol may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09295
Talniflumate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09299
Tenofovir alafenamide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB11367
Cefroxadine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB11455
Robenacoxib may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB11466
Tepoxalin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB11518
Flunixin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB11935
Flomoxef may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB12151
Brincidofovir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB12445
Nitroaspirin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB12545
Indobufen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13001
Tinoridine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13167
Alclofenac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13217
Fentiazac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13232
Suxibuzone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13266
Cefatrizine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13286
Bumadizone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13314
Alminoprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13371
Difenpiramide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13407
Nifenazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13432
Lonazolac may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13461
Cefcapene may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13470
Cefodizime may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13481
Tenidap may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13499
Cefsulodin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13504
Cefetamet may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13524
Propyphenazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13527
Proglumetacin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13538
Guacetisal may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13544
Ethenzamide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13612
Carbaspirin calcium may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13629
Mofebutazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13638
Cefbuperazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13649
Proquazone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13657
Benorilate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13667
Cefozopran may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13682
Cefpirome may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13722
Pirprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13778
Cefazedone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13783
Acemetacin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13821
Ceftezole may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13860
Imidazole salicylate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13868
Adefovir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB14059
SC-236 may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB14060
NS-398 may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB14126
Tenofovir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB14713
Inotersen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01438
Phenazopyridine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00864
Tacrolimus may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01072
Atazanavir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01601
Lopinavir may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01356
Lithium cation may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB14507
Lithium citrate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB09212
Loxoprofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00452
Framycetin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01421
Paromomycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04263
Geneticin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04626
Apramycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04808
Neamine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB08437
Puromycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB11512
Dihydrostreptomycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB11520
Hygromycin B may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00007
Leuprolide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00014
Goserelin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00017
Salmon calcitonin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00035
Desmopressin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00041
Aldesleukin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00080
Daptomycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00081
Tositumomab may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00115
Cyanocobalamin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00158
Folic acid may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00165
Pyridoxine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00181
Baclofen may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00182
Amphetamine may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00186
Cevimeline may decrease the excretion rate of Lorazepam which could result in a higher serum level.
DB00190
Cevimeline may decrease the excretion rate of Carbidopa which could result in a higher serum level.
DB00193
Cevimeline may decrease the excretion rate of Tramadol which could result in a higher serum level.
DB00196
Cevimeline may decrease the excretion rate of Fluconazole which could result in a higher serum level.
DB00198
Cevimeline may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
DB00200
Cevimeline may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00206
Cevimeline may decrease the excretion rate of Reserpine which could result in a higher serum level.
DB00213
Cevimeline may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
DB00225
Cevimeline may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
DB00230
Cevimeline may decrease the excretion rate of Pregabalin which could result in a higher serum level.
DB00231
Cevimeline may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00235
Cevimeline may decrease the excretion rate of Milrinone which could result in a higher serum level.
DB00237
Cevimeline may decrease the excretion rate of Butabarbital which could result in a higher serum level.
DB00245
Cevimeline may decrease the excretion rate of Benzatropine which could result in a higher serum level.
DB00254
Cevimeline may decrease the excretion rate of Doxycycline which could result in a higher serum level.
DB00262
Cevimeline may decrease the excretion rate of Carmustine which could result in a higher serum level.
DB00270
Cevimeline may decrease the excretion rate of Isradipine which could result in a higher serum level.
DB00271
Cevimeline may decrease the excretion rate of Diatrizoate which could result in a higher serum level.
DB00273
Cevimeline may decrease the excretion rate of Topiramate which could result in a higher serum level.
DB00279
Cevimeline may decrease the excretion rate of Liothyronine which could result in a higher serum level.
DB00280
Cevimeline may decrease the excretion rate of Disopyramide which could result in a higher serum level.
DB00284
Cevimeline may decrease the excretion rate of Acarbose which could result in a higher serum level.
DB00286
Cevimeline may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
DB00289
Cevimeline may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
DB00290
Cevimeline may decrease the excretion rate of Bleomycin which could result in a higher serum level.
DB00292
Cevimeline may decrease the excretion rate of Etomidate which could result in a higher serum level.
DB00294
Cevimeline may decrease the excretion rate of Etonogestrel which could result in a higher serum level.
DB00296
Cevimeline may decrease the excretion rate of Ropivacaine which could result in a higher serum level.
DB00303
Cevimeline may decrease the excretion rate of Ertapenem which could result in a higher serum level.
DB00308
Cevimeline may decrease the excretion rate of Ibutilide which could result in a higher serum level.
DB00316
Cevimeline may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
DB00319
Cevimeline may decrease the excretion rate of Piperacillin which could result in a higher serum level.
DB00322
Cevimeline may decrease the excretion rate of Floxuridine which could result in a higher serum level.
DB00323
Cevimeline may decrease the excretion rate of Tolcapone which could result in a higher serum level.
DB00325
Cevimeline may decrease the excretion rate of Nitroprusside which could result in a higher serum level.
DB00327
Cevimeline may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
DB00330
Cevimeline may decrease the excretion rate of Ethambutol which could result in a higher serum level.
DB00331
Cevimeline may decrease the excretion rate of Metformin which could result in a higher serum level.
DB00339
Cevimeline may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
DB00341
Cevimeline may decrease the excretion rate of Cetirizine which could result in a higher serum level.
DB00351
Cevimeline may decrease the excretion rate of Megestrol acetate which could result in a higher serum level.
DB00355
Cevimeline may decrease the excretion rate of Aztreonam which could result in a higher serum level.
DB00356
Cevimeline may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
DB00359
Cevimeline may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
DB00364
Cevimeline may decrease the excretion rate of Sucralfate which could result in a higher serum level.
DB00372
Cevimeline may decrease the excretion rate of Thiethylperazine which could result in a higher serum level.
DB00377
Cevimeline may decrease the excretion rate of Palonosetron which could result in a higher serum level.
DB00380
Cevimeline may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
DB00402
Cevimeline may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
DB00413
Cevimeline may decrease the excretion rate of Pramipexole which could result in a higher serum level.
DB00415
Cevimeline may decrease the excretion rate of Ampicillin which could result in a higher serum level.
DB00418
Cevimeline may decrease the excretion rate of Secobarbital which could result in a higher serum level.
DB00422
Cevimeline may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
DB00432
Cevimeline may decrease the excretion rate of Trifluridine which could result in a higher serum level.
DB00435
Cevimeline may decrease the excretion rate of Nitric Oxide which could result in a higher serum level.
DB00437
Cevimeline may decrease the excretion rate of Allopurinol which could result in a higher serum level.
DB00440
Cevimeline may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
DB00441
Cevimeline may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
DB00480
Cevimeline may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
DB00492
Cevimeline may decrease the excretion rate of Fosinopril which could result in a higher serum level.
DB00499
Cevimeline may decrease the excretion rate of Flutamide which could result in a higher serum level.
DB00535
Cevimeline may decrease the excretion rate of Cefdinir which could result in a higher serum level.
DB00537
Cevimeline may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
DB00548
Cevimeline may decrease the excretion rate of Azelaic acid which could result in a higher serum level.
DB00553
Cevimeline may decrease the excretion rate of Methoxsalen which could result in a higher serum level.
DB00555
Cevimeline may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
DB00558
Cevimeline may decrease the excretion rate of Zanamivir which could result in a higher serum level.
DB00569
Cevimeline may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
DB00583
Cevimeline may decrease the excretion rate of Levocarnitine which could result in a higher serum level.
DB00591
Cevimeline may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level.
DB00597
Cevimeline may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
DB00603
Cevimeline may decrease the excretion rate of Medroxyprogesterone acetate which could result in a higher serum level.
DB00624
Cevimeline may decrease the excretion rate of Testosterone which could result in a higher serum level.
DB00628
Cevimeline may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
DB00631
Cevimeline may decrease the excretion rate of Clofarabine which could result in a higher serum level.
DB00635
Cevimeline may decrease the excretion rate of Prednisone which could result in a higher serum level.
DB00651
Cevimeline may decrease the excretion rate of Dyphylline which could result in a higher serum level.
DB00657
Cevimeline may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
DB00660
Cevimeline may decrease the excretion rate of Metaxalone which could result in a higher serum level.
DB00665
Cevimeline may decrease the excretion rate of Nilutamide which could result in a higher serum level.
DB00669
Cevimeline may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
DB00672
Cevimeline may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
DB00688
Cevimeline may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
DB00690
Cevimeline may decrease the excretion rate of Flurazepam which could result in a higher serum level.
DB00692
Cevimeline may decrease the excretion rate of Phentolamine which could result in a higher serum level.
DB00698
Cevimeline may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
DB00706
Cevimeline may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
DB00709
Cevimeline may decrease the excretion rate of Lamivudine which could result in a higher serum level.
DB00713
Cevimeline may decrease the excretion rate of Oxacillin which could result in a higher serum level.
DB00716
Cevimeline may decrease the excretion rate of Nedocromil which could result in a higher serum level.
DB00722
Cevimeline may decrease the excretion rate of Lisinopril which could result in a higher serum level.
DB00730
Cevimeline may decrease the excretion rate of Thiabendazole which could result in a higher serum level.
DB00731
Cevimeline may decrease the excretion rate of Nateglinide which could result in a higher serum level.
DB00733
Cevimeline may decrease the excretion rate of Pralidoxime which could result in a higher serum level.
DB00743
Cevimeline may decrease the excretion rate of Gadobenic acid which could result in a higher serum level.
DB00759
Cevimeline may decrease the excretion rate of Tetracycline which could result in a higher serum level.
DB00760
Cevimeline may decrease the excretion rate of Meropenem which could result in a higher serum level.
DB00761
Cevimeline may decrease the excretion rate of Potassium chloride which could result in a higher serum level.
DB00775
Cevimeline may decrease the excretion rate of Tirofiban which could result in a higher serum level.
DB00782
Cevimeline may decrease the excretion rate of Propantheline which could result in a higher serum level.
DB00783
Cevimeline may decrease the excretion rate of Estradiol which could result in a higher serum level.
DB00789
Cevimeline may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
DB00790
Cevimeline may decrease the excretion rate of Perindopril which could result in a higher serum level.
DB00800
Cevimeline may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
DB00804
Cevimeline may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
DB00806
Cevimeline may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
DB00811
Cevimeline may decrease the excretion rate of Ribavirin which could result in a higher serum level.
DB00828
Cevimeline may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
DB00829
Cevimeline may decrease the excretion rate of Diazepam which could result in a higher serum level.
DB00839
Cevimeline may decrease the excretion rate of Tolazamide which could result in a higher serum level.
DB00841
Cevimeline may decrease the excretion rate of Dobutamine which could result in a higher serum level.
DB00842
Cevimeline may decrease the excretion rate of Oxazepam which could result in a higher serum level.
DB00851
Cevimeline may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
DB00853
Cevimeline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
DB00871
Cevimeline may decrease the excretion rate of Terbutaline which could result in a higher serum level.
DB00894
Cevimeline may decrease the excretion rate of Testolactone which could result in a higher serum level.
DB00900
Cevimeline may decrease the excretion rate of Didanosine which could result in a higher serum level.
DB00911
Cevimeline may decrease the excretion rate of Tinidazole which could result in a higher serum level.
DB00915
Cevimeline may decrease the excretion rate of Amantadine which could result in a higher serum level.
DB00918
Cevimeline may decrease the excretion rate of Almotriptan which could result in a higher serum level.
DB00928
Cevimeline may decrease the excretion rate of Azacitidine which could result in a higher serum level.
DB00934
Cevimeline may decrease the excretion rate of Maprotiline which could result in a higher serum level.
DB00951
Cevimeline may decrease the excretion rate of Isoniazid which could result in a higher serum level.
DB00953
Cevimeline may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
DB00961
Cevimeline may decrease the excretion rate of Mepivacaine which could result in a higher serum level.
DB00962
Cevimeline may decrease the excretion rate of Zaleplon which could result in a higher serum level.
DB00968
Cevimeline may decrease the excretion rate of Methyldopa which could result in a higher serum level.
DB00980
Cevimeline may decrease the excretion rate of Ramelteon which could result in a higher serum level.
DB00988
Cevimeline may decrease the excretion rate of Dopamine which could result in a higher serum level.
DB00993
Cevimeline may decrease the excretion rate of Azathioprine which could result in a higher serum level.
DB00995
Cevimeline may decrease the excretion rate of Auranofin which could result in a higher serum level.
DB01001
Cevimeline may decrease the excretion rate of Salbutamol which could result in a higher serum level.
DB01002
Cevimeline may decrease the excretion rate of Levobupivacaine which could result in a higher serum level.
DB01004
Cevimeline may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
DB01010
Cevimeline may decrease the excretion rate of Edrophonium which could result in a higher serum level.
DB01011
Cevimeline may decrease the excretion rate of Metyrapone which could result in a higher serum level.
DB01015
Cevimeline may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
DB01018
Cevimeline may decrease the excretion rate of Guanfacine which could result in a higher serum level.
DB01020
Cevimeline may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level.
DB01022
Cevimeline may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
DB01024
Cevimeline may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
DB01030
Cevimeline may decrease the excretion rate of Topotecan which could result in a higher serum level.
DB01032
Cevimeline may decrease the excretion rate of Probenecid which could result in a higher serum level.
DB01036
Cevimeline may decrease the excretion rate of Tolterodine which could result in a higher serum level.
DB01039
Cevimeline may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
DB01043
Cevimeline may decrease the excretion rate of Memantine which could result in a higher serum level.
DB01046
Cevimeline may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
DB01048
Cevimeline may decrease the excretion rate of Abacavir which could result in a higher serum level.
DB01060
Cevimeline may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
DB01067
Cevimeline may decrease the excretion rate of Glipizide which could result in a higher serum level.
DB01068
Cevimeline may decrease the excretion rate of Clonazepam which could result in a higher serum level.
DB01099
Cevimeline may decrease the excretion rate of Flucytosine which could result in a higher serum level.
DB01101
Cevimeline may decrease the excretion rate of Capecitabine which could result in a higher serum level.
DB01105
Cevimeline may decrease the excretion rate of Sibutramine which could result in a higher serum level.
DB01124
Cevimeline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
DB01129
Cevimeline may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
DB01133
Cevimeline may decrease the excretion rate of Tiludronic acid which could result in a higher serum level.
DB01135
Cevimeline may decrease the excretion rate of Doxacurium which could result in a higher serum level.
DB01137
Cevimeline may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
DB01148
Cevimeline may decrease the excretion rate of Flavoxate which could result in a higher serum level.
DB01157
Cevimeline may decrease the excretion rate of Trimetrexate which could result in a higher serum level.
DB01166
Cevimeline may decrease the excretion rate of Cilostazol which could result in a higher serum level.
DB01169
Cevimeline may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
DB01170
Cevimeline may decrease the excretion rate of Guanethidine which could result in a higher serum level.
DB01181
Cevimeline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
DB01205
Cevimeline may decrease the excretion rate of Flumazenil which could result in a higher serum level.
DB01213
Cevimeline may decrease the excretion rate of Fomepizole which could result in a higher serum level.
DB01215
Cevimeline may decrease the excretion rate of Estazolam which could result in a higher serum level.
DB01221
Cevimeline may decrease the excretion rate of Ketamine which could result in a higher serum level.
DB01240
Cevimeline may decrease the excretion rate of Epoprostenol which could result in a higher serum level.
DB01241
Cevimeline may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
DB01249
Cevimeline may decrease the excretion rate of Iodixanol which could result in a higher serum level.
DB01261
Cevimeline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
DB01267
Cevimeline may decrease the excretion rate of Paliperidone which could result in a higher serum level.
DB01273
Cevimeline may decrease the excretion rate of Varenicline which could result in a higher serum level.
DB01274
Cevimeline may decrease the excretion rate of Arformoterol which could result in a higher serum level.
DB01275
Cevimeline may decrease the excretion rate of Hydralazine which could result in a higher serum level.
DB01367
Cevimeline may decrease the excretion rate of Rasagiline which could result in a higher serum level.
DB01409
Cevimeline may decrease the excretion rate of Tiotropium which could result in a higher serum level.
DB01420
Cevimeline may decrease the excretion rate of Testosterone propionate which could result in a higher serum level.
DB01427
Cevimeline may decrease the excretion rate of Amrinone which could result in a higher serum level.
DB01428
Cevimeline may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
DB01431
Cevimeline may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
DB01550
Cevimeline may decrease the excretion rate of Fenproporex which could result in a higher serum level.
DB01558
Cevimeline may decrease the excretion rate of Bromazepam which could result in a higher serum level.
DB01563
Cevimeline may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
DB01577
Cevimeline may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
DB01587
Cevimeline may decrease the excretion rate of Ketazolam which could result in a higher serum level.
DB01610
Cevimeline may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
DB01638
Cevimeline may decrease the excretion rate of Sorbitol which could result in a higher serum level.
DB01656
Cevimeline may decrease the excretion rate of Roflumilast which could result in a higher serum level.
DB01685
Cevimeline may decrease the excretion rate of Topiroxostat which could result in a higher serum level.
DB04574
Cevimeline may decrease the excretion rate of Estrone sulfate which could result in a higher serum level.
DB04895
Cevimeline may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
DB04896
Cevimeline may decrease the excretion rate of Milnacipran which could result in a higher serum level.
DB04920
Cevimeline may decrease the excretion rate of Clevidipine which could result in a higher serum level.
DB04948
Cevimeline may decrease the excretion rate of Lofexidine which could result in a higher serum level.
DB04953
Cevimeline may decrease the excretion rate of Ezogabine which could result in a higher serum level.
DB05018
Cevimeline may decrease the excretion rate of Migalastat which could result in a higher serum level.
DB05541
Cevimeline may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
DB06154
Cevimeline may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level.
DB06186
Cevimeline may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
DB06196
Cevimeline may decrease the excretion rate of Icatibant which could result in a higher serum level.
DB06203
Cevimeline may decrease the excretion rate of Alogliptin which could result in a higher serum level.
DB06209
Cevimeline may decrease the excretion rate of Prasugrel which could result in a higher serum level.
DB06211
Cevimeline may decrease the excretion rate of Doripenem which could result in a higher serum level.
DB06230
Cevimeline may decrease the excretion rate of Nalmefene which could result in a higher serum level.
DB06262
Cevimeline may decrease the excretion rate of Droxidopa which could result in a higher serum level.
DB06282
Cevimeline may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
DB06335
Cevimeline may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
DB06402
Cevimeline may decrease the excretion rate of Telavancin which could result in a higher serum level.
DB06480
Cevimeline may decrease the excretion rate of Prucalopride which could result in a higher serum level.
DB06623
Cevimeline may decrease the excretion rate of Flupirtine which could result in a higher serum level.
DB06637
Cevimeline may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
DB06695
Cevimeline may decrease the excretion rate of Dabigatran etexilate which could result in a higher serum level.
DB06700
Cevimeline may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
DB06702
Cevimeline may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
DB06705
Cevimeline may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
DB06710
Cevimeline may decrease the excretion rate of Methyltestosterone which could result in a higher serum level.
DB06767
Cevimeline may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
DB06782
Cevimeline may decrease the excretion rate of Dimercaprol which could result in a higher serum level.
DB06796
Cevimeline may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
DB06800
Cevimeline may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
DB06809
Cevimeline may decrease the excretion rate of Plerixafor which could result in a higher serum level.
DB06813
Cevimeline may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
DB06823
Cevimeline may decrease the excretion rate of Tiopronin which could result in a higher serum level.
DB06824
Cevimeline may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level.
DB08824
Cevimeline may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
DB08826
Cevimeline may decrease the excretion rate of Deferiprone which could result in a higher serum level.
DB08840
Cevimeline may decrease the excretion rate of N-methylnicotinamide which could result in a higher serum level.
DB08872
Cevimeline may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level.
DB08877
Cevimeline may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
DB08894
Cevimeline may decrease the excretion rate of Peginesatide which could result in a higher serum level.
DB08897
Cevimeline may decrease the excretion rate of Aclidinium which could result in a higher serum level.
DB08900
Cevimeline may decrease the excretion rate of Teduglutide which could result in a higher serum level.
DB08905
Cevimeline may decrease the excretion rate of Formestane which could result in a higher serum level.
DB08910
Cevimeline may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
DB08911
Cevimeline may decrease the excretion rate of Trametinib which could result in a higher serum level.
DB08918
Cevimeline may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
DB08932
Cevimeline may decrease the excretion rate of Macitentan which could result in a higher serum level.
DB08934
Cevimeline may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
DB09027
Cevimeline may decrease the excretion rate of Ledipasvir which could result in a higher serum level.
DB09050
Cevimeline may decrease the excretion rate of Ceftolozane which could result in a higher serum level.
DB09066
Cevimeline may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level.
DB09068
Cevimeline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
DB09071
Cevimeline may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
DB09075
Cevimeline may decrease the excretion rate of Edoxaban which could result in a higher serum level.
DB09081
Cevimeline may decrease the excretion rate of Idebenone which could result in a higher serum level.
DB09082
Cevimeline may decrease the excretion rate of Vilanterol which could result in a higher serum level.
DB09089
Cevimeline may decrease the excretion rate of Trimebutine which could result in a higher serum level.
DB09091
Cevimeline may decrease the excretion rate of Tixocortol which could result in a higher serum level.
DB09103
Cevimeline may decrease the excretion rate of Ancestim which could result in a higher serum level.
DB09104
Cevimeline may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
DB09106
Cevimeline may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
DB09111
Cevimeline may decrease the excretion rate of Pentastarch which could result in a higher serum level.
DB09121
Cevimeline may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.
DB09123
Cevimeline may decrease the excretion rate of Dienogest which could result in a higher serum level.
DB09129
Cevimeline may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
DB09132
Cevimeline may decrease the excretion rate of Gadoteric acid which could result in a higher serum level.
DB09133
Cevimeline may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.
DB09134
Cevimeline may decrease the excretion rate of Ioversol which could result in a higher serum level.
DB09135
Cevimeline may decrease the excretion rate of Ioxilan which could result in a higher serum level.
DB09136
Cevimeline may decrease the excretion rate of Isosulfan blue which could result in a higher serum level.
DB09137
Cevimeline may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
DB09139
Cevimeline may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level.
DB09148
Cevimeline may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level.
DB09149
Cevimeline may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level.
DB09156
Cevimeline may decrease the excretion rate of Iopromide which could result in a higher serum level.
DB09163
Cevimeline may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level.
DB09165
Cevimeline may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level.
DB09185
Cevimeline may decrease the excretion rate of Viloxazine which could result in a higher serum level.
DB09194
Cevimeline may decrease the excretion rate of Etoperidone which could result in a higher serum level.
DB09195
Cevimeline may decrease the excretion rate of Lorpiprazole which could result in a higher serum level.
DB09205
Cevimeline may decrease the excretion rate of Moxisylyte which could result in a higher serum level.
DB09209
Cevimeline may decrease the excretion rate of Pholcodine which could result in a higher serum level.
DB09210
Cevimeline may decrease the excretion rate of Piracetam which could result in a higher serum level.
DB09219
Cevimeline may decrease the excretion rate of Bisoxatin which could result in a higher serum level.
DB09220
Cevimeline may decrease the excretion rate of Nicorandil which could result in a higher serum level.
DB09223
Cevimeline may decrease the excretion rate of Blonanserin which could result in a higher serum level.
DB09244
Cevimeline may decrease the excretion rate of Pirlindole which could result in a higher serum level.
DB09245
Cevimeline may decrease the excretion rate of Toloxatone which could result in a higher serum level.
DB09255
Cevimeline may decrease the excretion rate of Dextran which could result in a higher serum level.
DB09256
Cevimeline may decrease the excretion rate of Tegafur which could result in a higher serum level.
DB09257
Cevimeline may decrease the excretion rate of Gimeracil which could result in a higher serum level.
DB09262
Cevimeline may decrease the excretion rate of Imidafenacin which could result in a higher serum level.
DB09264
Cevimeline may decrease the excretion rate of Idarucizumab which could result in a higher serum level.
DB09265
Cevimeline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
DB09268
Cevimeline may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level.
DB09276
Cevimeline may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
DB09277
Cevimeline may decrease the excretion rate of Choline C 11 which could result in a higher serum level.
DB09281
Cevimeline may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.
DB09292
Cevimeline may decrease the excretion rate of Sacubitril which could result in a higher serum level.
DB09301
Cevimeline may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level.
DB09317
Cevimeline may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level.
DB09318
Cevimeline may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level.
DB09320
Cevimeline may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
DB09324
Cevimeline may decrease the excretion rate of Sulbactam which could result in a higher serum level.
DB09325
Cevimeline may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
DB09329
Cevimeline may decrease the excretion rate of Antihemophilic Factor (Recombinant), PEGylated which could result in a higher serum level.
DB09344
Cevimeline may decrease the excretion rate of Invert sugar which could result in a higher serum level.
DB09357
Cevimeline may decrease the excretion rate of Dexpanthenol which could result in a higher serum level.
DB09394
Cevimeline may decrease the excretion rate of Phosphoric acid which could result in a higher serum level.
DB09395
Cevimeline may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
DB09407
Cevimeline may decrease the excretion rate of Magnesium chloride which could result in a higher serum level.
DB09418
Cevimeline may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level.
DB09472
Cevimeline may decrease the excretion rate of Sodium sulfate which could result in a higher serum level.
DB09477
Cevimeline may decrease the excretion rate of Enalaprilat which could result in a higher serum level.
DB09481
Cevimeline may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
DB09488
Cevimeline may decrease the excretion rate of Acrivastine which could result in a higher serum level.
DB09496
Cevimeline may decrease the excretion rate of Octinoxate which could result in a higher serum level.
DB09502
Cevimeline may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
DB09546
Cevimeline may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level.
DB09570
Cevimeline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
DB11077
Cevimeline may decrease the excretion rate of Polyethylene glycol 400 which could result in a higher serum level.
DB11090
Cevimeline may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
DB11098
Cevimeline may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
DB11102
Cevimeline may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
DB11114
Cevimeline may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
DB11127
Cevimeline may decrease the excretion rate of Selenious acid which could result in a higher serum level.
DB11130
Cevimeline may decrease the excretion rate of Opium which could result in a higher serum level.
DB11135
Cevimeline may decrease the excretion rate of Selenium which could result in a higher serum level.
DB11136
Cevimeline may decrease the excretion rate of Chromium which could result in a higher serum level.
DB11145
Cevimeline may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
DB11156
Cevimeline may decrease the excretion rate of Pyrantel which could result in a higher serum level.
DB11164
Cevimeline may decrease the excretion rate of Bicisate which could result in a higher serum level.
DB11251
Cevimeline may decrease the excretion rate of Tocopherol which could result in a higher serum level.
DB11278
Cevimeline may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level.
DB11328
Cevimeline may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
DB11338
Cevimeline may decrease the excretion rate of Clove oil which could result in a higher serum level.
DB11358
Cevimeline may decrease the excretion rate of Evening primrose oil which could result in a higher serum level.
DB11364
Cevimeline may decrease the excretion rate of Pidotimod which could result in a higher serum level.
DB11560
Cevimeline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
DB11577
Cevimeline may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level.
DB11587
Cevimeline may decrease the excretion rate of Etafedrine which could result in a higher serum level.
DB11598
Cevimeline may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
DB11691
Cevimeline may decrease the excretion rate of Naldemedine which could result in a higher serum level.
DB11699
Cevimeline may decrease the excretion rate of Tropisetron which could result in a higher serum level.
DB11817
Cevimeline may decrease the excretion rate of Baricitinib which could result in a higher serum level.
DB11915
Cevimeline may decrease the excretion rate of Valbenazine which could result in a higher serum level.
DB11943
Cevimeline may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
DB11989
Cevimeline may decrease the excretion rate of Benznidazole which could result in a higher serum level.
DB12007
Cevimeline may decrease the excretion rate of Isoflavone which could result in a higher serum level.
DB12107
Cevimeline may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
DB12161
Cevimeline may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
DB12278
Cevimeline may decrease the excretion rate of Propiverine which could result in a higher serum level.
DB12783
Cevimeline may decrease the excretion rate of Benserazide which could result in a higher serum level.
DB13025
Cevimeline may decrease the excretion rate of Tiapride which could result in a higher serum level.
DB13156
Cevimeline may decrease the excretion rate of Inosine pranobex which could result in a higher serum level.
DB13178
Cevimeline may decrease the excretion rate of Inositol which could result in a higher serum level.
DB13185
Cevimeline may decrease the excretion rate of Oxabolone cipionate which could result in a higher serum level.
DB13191
Cevimeline may decrease the excretion rate of Phosphocreatine which could result in a higher serum level.
DB13269
Cevimeline may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
DB13293
Cevimeline may decrease the excretion rate of Ipecac which could result in a higher serum level.
DB13595
Cevimeline may decrease the excretion rate of Almasilate which could result in a higher serum level.
DB13873
Cevimeline may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
DB13884
Cevimeline may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
DB13909
Cevimeline may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
DB13943
Cevimeline may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
DB13944
Cevimeline may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.
DB13946
Cevimeline may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level.
DB13952
Cevimeline may decrease the excretion rate of Estradiol acetate which could result in a higher serum level.
DB13954
Cevimeline may decrease the excretion rate of Estradiol cypionate which could result in a higher serum level.
DB13955
Cevimeline may decrease the excretion rate of Estradiol dienanthate which could result in a higher serum level.
DB13956
Cevimeline may decrease the excretion rate of Estradiol valerate which could result in a higher serum level.
DB13967
Cevimeline may decrease the excretion rate of Patent Blue which could result in a higher serum level.
DB14006
Cevimeline may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
DB14007
Cevimeline may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
DB14498
Cevimeline may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
DB14499
Cevimeline may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
DB14526
Cevimeline may decrease the excretion rate of Chromic citrate which could result in a higher serum level.
DB14527
Cevimeline may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
DB14528
Cevimeline may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
DB14529
Cevimeline may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.
DB14530
Cevimeline may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
DB14754
Cevimeline may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
DB06815
Cevimeline may decrease the excretion rate of Pyrithione which could result in a higher serum level.
DB11121
Cevimeline may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
DB11085
Cevimeline may decrease the excretion rate of Resorcinol which could result in a higher serum level.
DB01149
Nefazodone may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00312
Cevimeline may decrease the excretion rate of Pentobarbital which could result in a higher serum level.
DB00401
Cevimeline may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
DB00404
Cevimeline may decrease the excretion rate of Alprazolam which could result in a higher serum level.
DB00490
Cevimeline may decrease the excretion rate of Buspirone which could result in a higher serum level.
DB00683
Cevimeline may decrease the excretion rate of Midazolam which could result in a higher serum level.
DB00820
Cevimeline may decrease the excretion rate of Tadalafil which could result in a higher serum level.
DB00897
Cevimeline may decrease the excretion rate of Triazolam which could result in a higher serum level.
DB01183
Cevimeline may decrease the excretion rate of Naloxone which could result in a higher serum level.
DB01222
Cevimeline may decrease the excretion rate of Budesonide which could result in a higher serum level.
DB01224
Cevimeline may decrease the excretion rate of Quetiapine which could result in a higher serum level.
DB01394
Cevimeline may decrease the excretion rate of Colchicine which could result in a higher serum level.
DB06228
Cevimeline may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
DB08899
Cevimeline may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
DB11901
Cevimeline may decrease the excretion rate of Apalutamide which could result in a higher serum level.
DB15593
Cevimeline may decrease the excretion rate of Golodirsen which could result in a higher serum level.
DB00318
Cevimeline may decrease the excretion rate of Codeine which could result in a higher serum level.
DB00454
Cevimeline may decrease the excretion rate of Meperidine which could result in a higher serum level.
DB00813
Cevimeline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
DB00879
Cevimeline may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
DB08996
Cevimeline may decrease the excretion rate of Dimetacrine which could result in a higher serum level.
DB14506
Cevimeline may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level.
DB13987
Cevimeline may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
DB04890
Cevimeline may decrease the excretion rate of Bepotastine which could result in a higher serum level.
DB00982
Cevimeline may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
DB04930
Cevimeline may decrease the excretion rate of Permethrin which could result in a higher serum level.
DB09095
Cevimeline may decrease the excretion rate of Difluocortolone which could result in a higher serum level.
DB00479
Amikacin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00684
Tobramycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00798
Gentamicin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00955
Netilmicin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00994
Neomycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01082
Streptomycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB01172
Kanamycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB03615
Ribostamycin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB04729
Gentamicin C1a may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB06696
Arbekacin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB12604
Sisomicin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB13540
Isepamicin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00552
Cevimeline may decrease the excretion rate of Pentostatin which could result in a higher serum level.
DB13145
Cevimeline may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
DB00314
Cevimeline may decrease the excretion rate of Capreomycin which could result in a higher serum level.
DB00390
Cevimeline may decrease the excretion rate of Digoxin which could result in a higher serum level.
DB00512
Cevimeline may decrease the excretion rate of Vancomycin which could result in a higher serum level.
DB00515
Cevimeline may decrease the excretion rate of Cisplatin which could result in a higher serum level.
DB00642
Cevimeline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
DB12615
Cevimeline may decrease the excretion rate of Plazomicin which could result in a higher serum level.
DB14509
Cevimeline may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
DB00564
Cevimeline may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
DB00682
Cevimeline may decrease the excretion rate of Warfarin which could result in a higher serum level.
DB00803
Colistin may decrease the excretion rate of Cevimeline which could result in a higher serum level.
DB00524
Cevimeline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
DB00695
Cevimeline may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
DB00808
Cevimeline may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
DB00887
Cevimeline may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
DB00909
Cevimeline may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
DB08907
Cevimeline may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
DB09338
Cevimeline may increase the excretion rate of Mersalyl which could result in a lower serum level and potentially a reduction in efficacy.
DB00214
Torasemide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00232
Methyclothiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00310
Chlorthalidone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00311
Ethoxzolamide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00421
Spironolactone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00436
Bendroflumethiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00562
Benzthiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00594
Amiloride may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00606
Cyclothiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00774
Hydroflumethiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00880
Chlorothiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01021
Trichlormethiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01119
Diazoxide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01144
Diclofenamide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01324
Polythiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01325
Quinethazone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01412
Theobromine may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB02925
Piretanide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB04831
Tienilic acid may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB05034
Ularitide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB08961
Azosemide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB09015
Canrenoic acid may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB09125
Potassium citrate may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB09401
Isosorbide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB11827
Ertugliflozin may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB12221
Canrenone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB12670
Rolofylline may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB12704
Spiradoline may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB12766
Cicletanine may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13284
Meticrane may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13405
Mefruside may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13430
Mebutizide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13532
Cyclopenthiazide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13617
Clorexolone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13663
Clofenamide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13708
Fenquizone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13792
Clopamide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13801
Muzolimine may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13803
Xipamide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB13989
Epitizide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB14018
Bromotheophylline may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB14500
Potassium may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00703
Methazolamide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00700
Eplerenone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00819
Acetazolamide may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB00872
Conivaptan may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01395
Drospirenone may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB06212
Tolvaptan may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB06292
Dapagliflozin may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB09235
Efonidipine may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
DB01345
Cevimeline may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
DB09046
The metabolism of Cevimeline can be increased when combined with Metreleptin.
DB00208
The metabolism of Ticlopidine can be decreased when combined with Cevimeline.
DB00398
The metabolism of Sorafenib can be decreased when combined with Cevimeline.
DB00661
The metabolism of Verapamil can be decreased when combined with Cevimeline.
DB00780
The metabolism of Phenelzine can be decreased when combined with Cevimeline.
DB00863
The metabolism of Ranitidine can be decreased when combined with Cevimeline.
DB01093
The metabolism of Dimethyl sulfoxide can be decreased when combined with Cevimeline.
DB01115
The metabolism of Nifedipine can be decreased when combined with Cevimeline.
DB09241
The metabolism of Methylene blue can be decreased when combined with Cevimeline.
DB13139
The metabolism of Levosalbutamol can be decreased when combined with Cevimeline.
DB01244
The metabolism of Bepridil can be decreased when combined with Cevimeline.
DB09061
The metabolism of Cannabidiol can be decreased when combined with Cevimeline.
DB14011
The metabolism of Nabiximols can be decreased when combined with Cevimeline.
DB00215
The metabolism of Cevimeline can be decreased when combined with Citalopram.
DB00281
The metabolism of Cevimeline can be decreased when combined with Lidocaine.
DB00283
The metabolism of Cevimeline can be decreased when combined with Clemastine.
DB00412
The metabolism of Cevimeline can be decreased when combined with Rosiglitazone.
DB00557
The metabolism of Cevimeline can be decreased when combined with Hydroxyzine.
DB00574
The metabolism of Cevimeline can be decreased when combined with Fenfluramine.
DB00598
The metabolism of Cevimeline can be decreased when combined with Labetalol.
DB00633
The metabolism of Cevimeline can be decreased when combined with Dexmedetomidine.
DB00656
The metabolism of Cevimeline can be decreased when combined with Trazodone.
DB00792
The metabolism of Cevimeline can be decreased when combined with Tripelennamine.
DB00810
The metabolism of Cevimeline can be decreased when combined with Biperiden.
DB00850
The metabolism of Cevimeline can be decreased when combined with Perphenazine.
DB00907
The metabolism of Cevimeline can be decreased when combined with Cocaine.
DB01005
The metabolism of Cevimeline can be decreased when combined with Hydroxyurea.
DB01069
The metabolism of Cevimeline can be decreased when combined with Promethazine.
DB01075
The metabolism of Cevimeline can be decreased when combined with Diphenhydramine.
DB01114
The metabolism of Cevimeline can be decreased when combined with Chlorpheniramine.
DB01128
The metabolism of Cevimeline can be decreased when combined with Bicalutamide.
DB01171
The metabolism of Cevimeline can be decreased when combined with Moclobemide.
DB01193
The metabolism of Cevimeline can be decreased when combined with Acebutolol.
DB01233
The metabolism of Cevimeline can be decreased when combined with Metoclopramide.
DB01580
The metabolism of Cevimeline can be decreased when combined with Oxprenolol.
DB01611
The metabolism of Cevimeline can be decreased when combined with Hydroxychloroquine.
DB01621
The metabolism of Cevimeline can be decreased when combined with Pipotiazine.
DB04818
The metabolism of Cevimeline can be decreased when combined with Iproniazid.
DB04884
The metabolism of Cevimeline can be decreased when combined with Dapoxetine.
DB05271
The metabolism of Cevimeline can be decreased when combined with Rotigotine.
DB06204
The metabolism of Cevimeline can be decreased when combined with Tapentadol.
DB06217
The metabolism of Cevimeline can be decreased when combined with Vernakalant.
DB06654
The metabolism of Cevimeline can be decreased when combined with Safinamide.
DB06727
The metabolism of Cevimeline can be decreased when combined with Sparteine.
DB09078
The metabolism of Cevimeline can be decreased when combined with Lenvatinib.
DB09224
The metabolism of Cevimeline can be decreased when combined with Melperone.
DB09555
The metabolism of Cevimeline can be decreased when combined with Dexchlorpheniramine maleate.
DB11638
The metabolism of Cevimeline can be decreased when combined with Artenimol.
DB11994
The metabolism of Cevimeline can be decreased when combined with Diacerein.
DB12523
The metabolism of Cevimeline can be decreased when combined with Mizolastine.
DB13679
The metabolism of Cevimeline can be decreased when combined with Dexchlorpheniramine.
DB00220
The metabolism of Nelfinavir can be decreased when combined with Cevimeline.
DB06691
The metabolism of Cevimeline can be decreased when combined with Mepyramine.
DB00528
The metabolism of Lercanidipine can be decreased when combined with Cevimeline.
DB01096
The metabolism of Cevimeline can be decreased when combined with Oxamniquine.
DB01562
The metabolism of Cevimeline can be decreased when combined with 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine.
DB00333
The metabolism of Cevimeline can be decreased when combined with Methadone.
DB00439
The metabolism of Cevimeline can be decreased when combined with Cerivastatin.
DB00647
The metabolism of Cevimeline can be decreased when combined with Dextropropoxyphene.
DB00763
The metabolism of Cevimeline can be decreased when combined with Methimazole.
DB00834
The metabolism of Cevimeline can be decreased when combined with Mifepristone.
DB00972
The metabolism of Cevimeline can be decreased when combined with Azelastine.
DB00997
The metabolism of Cevimeline can be decreased when combined with Doxorubicin.
DB01023
The metabolism of Cevimeline can be decreased when combined with Felodipine.
DB01062
The metabolism of Cevimeline can be decreased when combined with Oxybutynin.
DB01110
The metabolism of Cevimeline can be decreased when combined with Miconazole.
DB01388
The metabolism of Cevimeline can be decreased when combined with Mibefradil.
DB01590
The metabolism of Cevimeline can be decreased when combined with Everolimus.
DB06370
The metabolism of Cevimeline can be decreased when combined with Indisulam.
DB06412
The metabolism of Cevimeline can be decreased when combined with Oxymetholone.
DB08864
The metabolism of Cevimeline can be decreased when combined with Rilpivirine.
DB09039
The metabolism of Cevimeline can be decreased when combined with Eliglustat.
DB09049
The metabolism of Cevimeline can be decreased when combined with Naloxegol.
DB09118
The metabolism of Cevimeline can be decreased when combined with Stiripentol.
DB11633
The metabolism of Cevimeline can be decreased when combined with Isavuconazole.
DB11753
The metabolism of Cevimeline can be decreased when combined with Rifamycin.
DB12245
The metabolism of Cevimeline can be decreased when combined with Triclabendazole.
DB13975
The metabolism of Cevimeline can be decreased when combined with Black cohosh.
DB14009
The metabolism of Cevimeline can be decreased when combined with Medical Cannabis.
DB14635
The metabolism of Cevimeline can be decreased when combined with Curcumin sulfate.
DB00627
The metabolism of Cevimeline can be decreased when combined with Niacin.
DB01142
The metabolism of Cevimeline can be decreased when combined with Doxepin.
DB12500
The metabolism of Cevimeline can be decreased when combined with Fedratinib.
DB00022
The metabolism of Cevimeline can be decreased when combined with Peginterferon alfa-2b.
DB00209
The metabolism of Cevimeline can be decreased when combined with Trospium.
DB00494
The metabolism of Cevimeline can be decreased when combined with Entacapone.
DB00623
The metabolism of Cevimeline can be decreased when combined with Fluphenazine.
DB01191
The metabolism of Cevimeline can be decreased when combined with Dexfenfluramine.
DB01255
The metabolism of Cevimeline can be decreased when combined with Lisdexamfetamine.
DB06512
The metabolism of Cevimeline can be decreased when combined with Deramciclane.
DB01131
The metabolism of Cevimeline can be decreased when combined with Proguanil.
DB00227
The metabolism of Cevimeline can be decreased when combined with Lovastatin.
DB00234
The metabolism of Cevimeline can be decreased when combined with Reboxetine.
DB00238
The metabolism of Cevimeline can be decreased when combined with Nevirapine.
DB00317
The metabolism of Cevimeline can be decreased when combined with Gefitinib.
DB00338
The metabolism of Cevimeline can be decreased when combined with Omeprazole.
DB00361
The metabolism of Cevimeline can be decreased when combined with Vinorelbine.
DB00448
The metabolism of Cevimeline can be decreased when combined with Lansoprazole.
DB00570
The metabolism of Cevimeline can be decreased when combined with Vinblastine.
DB00619
The metabolism of Cevimeline can be decreased when combined with Imatinib.
DB00921
The metabolism of Cevimeline can be decreased when combined with Buprenorphine.
DB01037
The metabolism of Cevimeline can be decreased when combined with Selegiline.
DB01104
The metabolism of Cevimeline can be decreased when combined with Sertraline.
DB01232
The metabolism of Cevimeline can be decreased when combined with Saquinavir.
DB01323
The metabolism of Cevimeline can be decreased when combined with St. John's Wort.
DB04938
The metabolism of Cevimeline can be decreased when combined with Ospemifene.
DB06287
The metabolism of Cevimeline can be decreased when combined with Temsirolimus.
DB06589
The metabolism of Cevimeline can be decreased when combined with Pazopanib.
DB08881
The metabolism of Cevimeline can be decreased when combined with Vemurafenib.
DB09065
The metabolism of Cevimeline can be decreased when combined with Cobicistat.
DB11837
The metabolism of Cevimeline can be decreased when combined with Osilodrostat.
DB04911
The metabolism of Cevimeline can be decreased when combined with Oritavancin.
DB01118
The metabolism of Cevimeline can be decreased when combined with Amiodarone.
DB00409
The metabolism of Remoxipride can be decreased when combined with Cevimeline.
DB00592
The metabolism of Piperazine can be decreased when combined with Cevimeline.
DB00699
The metabolism of Nicergoline can be decreased when combined with Cevimeline.
DB00737
The metabolism of Meclizine can be decreased when combined with Cevimeline.
DB00805
The metabolism of Minaprine can be decreased when combined with Cevimeline.
DB00914
The metabolism of Phenformin can be decreased when combined with Cevimeline.
DB00933
The metabolism of Mesoridazine can be decreased when combined with Cevimeline.
DB00983
The metabolism of Formoterol can be decreased when combined with Cevimeline.
DB01177
The metabolism of Idarubicin can be decreased when combined with Cevimeline.
DB01228
The metabolism of Encainide can be decreased when combined with Cevimeline.
DB01429
The metabolism of Aprindine can be decreased when combined with Cevimeline.
DB01454
The metabolism of Midomafetamine can be decreased when combined with Cevimeline.
DB01472
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Cevimeline.
DB01576
The metabolism of Dextroamphetamine can be decreased when combined with Cevimeline.
DB04840
The metabolism of Debrisoquine can be decreased when combined with Cevimeline.
DB04844
The metabolism of Tetrabenazine can be decreased when combined with Cevimeline.
DB06506
The metabolism of Repinotan can be decreased when combined with Cevimeline.
DB06608
The metabolism of Tafenoquine can be decreased when combined with Cevimeline.
DB06678
The metabolism of Esmirtazapine can be decreased when combined with Cevimeline.
DB06735
The metabolism of Enclomiphene can be decreased when combined with Cevimeline.
DB06770
The metabolism of Benzyl alcohol can be decreased when combined with Cevimeline.
DB09076
The metabolism of Umeclidinium can be decreased when combined with Cevimeline.
DB11855
The metabolism of Revefenacin can be decreased when combined with Cevimeline.
DB11979
The metabolism of Elagolix can be decreased when combined with Cevimeline.
DB00184
The metabolism of Cevimeline can be decreased when combined with Nicotine.
DB09173
The metabolism of Butyrfentanyl can be decreased when combined with Cevimeline.
DB00334
The metabolism of Olanzapine can be decreased when combined with Cevimeline.
DB04889
The metabolism of Bicifadine can be decreased when combined with Cevimeline.
DB14010
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Cevimeline.
DB00188
The metabolism of Bortezomib can be decreased when combined with Cevimeline.
DB00203
The metabolism of Sildenafil can be decreased when combined with Cevimeline.
DB00216
The metabolism of Eletriptan can be decreased when combined with Cevimeline.
DB00297
The metabolism of Bupivacaine can be decreased when combined with Cevimeline.
DB00343
The metabolism of Diltiazem can be decreased when combined with Cevimeline.
DB00370
The metabolism of Mirtazapine can be decreased when combined with Cevimeline.
DB00379
The metabolism of Mexiletine can be decreased when combined with Cevimeline.
DB00396
The metabolism of Progesterone can be decreased when combined with Cevimeline.
DB00420
The metabolism of Promazine can be decreased when combined with Cevimeline.
DB00425
The metabolism of Zolpidem can be decreased when combined with Cevimeline.
DB00433
The metabolism of Prochlorperazine can be decreased when combined with Cevimeline.
DB00497
The metabolism of Oxycodone can be decreased when combined with Cevimeline.
DB00514
The metabolism of Dextromethorphan can be decreased when combined with Cevimeline.
DB00568
The metabolism of Cinnarizine can be decreased when combined with Cevimeline.
DB00589
The metabolism of Lisuride can be decreased when combined with Cevimeline.
DB00590
The metabolism of Doxazosin can be decreased when combined with Cevimeline.
DB00641
The metabolism of Simvastatin can be decreased when combined with Cevimeline.
DB00701
The metabolism of Amprenavir can be decreased when combined with Cevimeline.
DB00757
The metabolism of Dolasetron can be decreased when combined with Cevimeline.
DB00836
The metabolism of Loperamide can be decreased when combined with Cevimeline.
DB00904
The metabolism of Ondansetron can be decreased when combined with Cevimeline.
DB01028
The metabolism of Methoxyflurane can be decreased when combined with Cevimeline.
DB01071
The metabolism of Mequitazine can be decreased when combined with Cevimeline.
DB01095
The metabolism of Fluvastatin can be decreased when combined with Cevimeline.
DB01184
The metabolism of Domperidone can be decreased when combined with Cevimeline.
DB01192
The metabolism of Oxymorphone can be decreased when combined with Cevimeline.
DB01238
The metabolism of Aripiprazole can be decreased when combined with Cevimeline.
DB01392
The metabolism of Yohimbine can be decreased when combined with Cevimeline.
DB01410
The metabolism of Ciclesonide can be decreased when combined with Cevimeline.
DB01466
The metabolism of Ethylmorphine can be decreased when combined with Cevimeline.
DB01551
The metabolism of Dihydrocodeine can be decreased when combined with Cevimeline.
DB01591
The metabolism of Solifenacin can be decreased when combined with Cevimeline.
DB01624
The metabolism of Zuclopenthixol can be decreased when combined with Cevimeline.
DB03783
The metabolism of Phenacetin can be decreased when combined with Cevimeline.
DB04829
The metabolism of Lysergic acid diethylamide can be decreased when combined with Cevimeline.
DB04841
The metabolism of Flunarizine can be decreased when combined with Cevimeline.
DB04905
The metabolism of Tesmilifene can be decreased when combined with Cevimeline.
DB04946
The metabolism of Iloperidone can be decreased when combined with Cevimeline.
DB06016
The metabolism of Cariprazine can be decreased when combined with Cevimeline.
DB06144
The metabolism of Sertindole can be decreased when combined with Cevimeline.
DB06148
The metabolism of Mianserin can be decreased when combined with Cevimeline.
DB08922
The metabolism of Perospirone can be decreased when combined with Cevimeline.
DB09048
The metabolism of Netupitant can be decreased when combined with Cevimeline.
DB09053
The metabolism of Ibrutinib can be decreased when combined with Cevimeline.
DB09128
The metabolism of Brexpiprazole can be decreased when combined with Cevimeline.
DB09183
The metabolism of Dasabuvir can be decreased when combined with Cevimeline.
DB11614
The metabolism of Rupatadine can be decreased when combined with Cevimeline.
DB11757
The metabolism of Istradefylline can be decreased when combined with Cevimeline.
DB12070
The metabolism of Letermovir can be decreased when combined with Cevimeline.
DB14185
The metabolism of Aripiprazole lauroxil can be decreased when combined with Cevimeline.
DB00252
The metabolism of Phenytoin can be decreased when combined with Cevimeline.
DB00734
The metabolism of Risperidone can be decreased when combined with Cevimeline.
DB00344
The metabolism of Protriptyline can be decreased when combined with Cevimeline.
DB00532
The metabolism of Mephenytoin can be decreased when combined with Cevimeline.
DB12930
The metabolism of Opipramol can be decreased when combined with Cevimeline.
DB00674
The metabolism of Galantamine can be decreased when combined with Cevimeline.
DB14881
The metabolism of Oliceridine can be decreased when combined with Cevimeline.
DB00751
The metabolism of Epinastine can be decreased when combined with Cevimeline.
DB11718
The metabolism of Encorafenib can be decreased when combined with Cevimeline.
DB11963
The metabolism of Cevimeline can be decreased when combined with Dacomitinib.
DB00489
The metabolism of Sotalol can be decreased when combined with Cevimeline.
DB01035
The metabolism of Procainamide can be decreased when combined with Cevimeline.
DB01195
The metabolism of Flecainide can be decreased when combined with Cevimeline.
DB00675
The metabolism of Cevimeline can be decreased when combined with Tamoxifen.
DB01100
The metabolism of Cevimeline can be decreased when combined with Pimozide.
DB13874
The metabolism of Cevimeline can be decreased when combined with Enasidenib.
DB00277
The metabolism of Theophylline can be decreased when combined with Cevimeline.
DB00530
The metabolism of Erlotinib can be decreased when combined with Cevimeline.
DB00637
The metabolism of Astemizole can be decreased when combined with Cevimeline.
DB05109
The metabolism of Trabectedin can be decreased when combined with Cevimeline.
DB08901
The metabolism of Ponatinib can be decreased when combined with Cevimeline.
DB00321
The metabolism of Cevimeline can be decreased when combined with Amitriptyline.
DB01242
The metabolism of Clomipramine can be decreased when combined with Cevimeline.
DB00543
The metabolism of Cevimeline can be decreased when combined with Amoxapine.
DB00540
The metabolism of Nortriptyline can be decreased when combined with Cevimeline.
DB00575
The metabolism of Clonidine can be decreased when combined with Cevimeline.
DB00726
The metabolism of Trimipramine can be decreased when combined with Cevimeline.
DB05676
The metabolism of Apremilast can be increased when combined with Cevimeline.
DB08904
The metabolism of Certolizumab pegol can be increased when combined with Cevimeline.
DB00005
The metabolism of Cevimeline can be increased when combined with Etanercept.
DB00026
The metabolism of Cevimeline can be increased when combined with Anakinra.
DB00051
The metabolism of Cevimeline can be increased when combined with Adalimumab.
DB00065
The metabolism of Cevimeline can be increased when combined with Infliximab.
DB01281
The metabolism of Cevimeline can be increased when combined with Abatacept.
DB04956
The metabolism of Cevimeline can be increased when combined with Afelimomab.
DB06168
The metabolism of Cevimeline can be increased when combined with Canakinumab.
DB06273
The metabolism of Cevimeline can be increased when combined with Tocilizumab.
DB06372
The metabolism of Cevimeline can be increased when combined with Rilonacept.
DB06674
The metabolism of Cevimeline can be increased when combined with Golimumab.
DB09029
The metabolism of Cevimeline can be increased when combined with Secukinumab.
DB09036
The metabolism of Cevimeline can be increased when combined with Siltuximab.
DB14724
The metabolism of Cevimeline can be increased when combined with Emapalumab.
DB00843
The risk or severity of adverse effects can be increased when Cevimeline is combined with Donepezil.
DB01175
The serum concentration of Cevimeline can be increased when it is combined with Escitalopram.
DB04855
The metabolism of Dronedarone can be decreased when combined with Cevimeline.
DB15066
The serum concentration of Cevimeline can be increased when it is combined with Givosiran.
DB06119
The serum concentration of Cevimeline can be decreased when it is combined with Cenobamate.
DB00243
The serum concentration of Cevimeline can be increased when it is combined with Ranolazine.
DB00503
The serum concentration of Cevimeline can be increased when it is combined with Ritonavir.
DB00502
The serum concentration of Cevimeline can be increased when it is combined with Haloperidol.
DB11652
The metabolism of Tucatinib can be decreased when combined with Cevimeline.
DB00472
The serum concentration of Cevimeline can be increased when it is combined with Fluoxetine.
DB11932
The serum concentration of Cevimeline can be increased when it is combined with Abametapir.
DB15762
The serum concentration of Cevimeline can be decreased when it is combined with Satralizumab.

序列

实验性质

Water Solubility
Very soluble

Melting Point
201-203 °C (HCl salt)

logP
1.3

外部标识符

resource：ChEBI
identifier：3568
resource：PubChem Compound
identifier：25137844
resource：PubChem Substance
identifier：46507202
resource：KEGG Drug
identifier：D00661
resource：ChemSpider
identifier：21864737
resource：PharmGKB
identifier：PA164754754
resource：Therapeutic Targets Database
identifier：DAP000075
resource：Wikipedia
identifier：Cevimeline
resource：RxCUI
identifier：44281

外部链接

RxList
http://www.rxlist.com/cgi/generic/cevimeline.htm
Drugs.com
http://www.drugs.com/cdi/cevimeline.html

路径

目标

id:BE0000045
name:Muscarinic acetylcholine receptor M3
organism:Humans
action:agonist
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Li X, Azlina A, Karabasil MR, Purwanti N, Hasegawa T, Yao C, Akamatsu T, Hosoi K: Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist. Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G112-G123. doi: 10.1152/ajpgi.00359.2007. Epub 2008 May 1.
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
known-action:yes
name:Muscarinic acetylcholine receptor M3
general-function:Receptor activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
gene-name:CHRM3
locus:1q43
cellular-location:Cell membrane
transmembrane-regions:68-91 105-130 143-164 185-206 230-252 492-514 527-546
signal-regions:
theoretical-pi:9.62
molecular-weight:66127.445
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1952GenAtlasCHRM3GenBank Gene DatabaseX15266GenBank Protein Database32324IUPHAR15Guide to Pharmacology15UniProtKBP20309UniProt AccessionACM3_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0009898|Muscarinic acetylcholine receptor M3 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
gene-sequence:>lcl|BSEQ0009899|Muscarinic acetylcholine receptor M3 (CHRM3) ATGACCTTGCACAATAACAGTACAACCTCGCCTTTGTTTCCAAACATCAGCTCCTCCTGG ATACACAGCCCCTCCGATGCAGGGCTGCCCCCGGGAACCGTCACTCATTTCGGCAGCTAC AATGTTTCTCGAGCAGCTGGCAATTTCTCCTCTCCAGACGGTACCACCGATGACCCTCTG GGAGGTCATACCGTCTGGCAAGTGGTCTTCATCGCTTTCTTAACGGGCATCCTGGCCTTG GTGACCATCATCGGCAACATCCTGGTAATTGTGTCATTTAAGGTCAACAAGCAGCTGAAG ACGGTCAACAACTACTTCCTCTTAAGCCTGGCCTGTGCCGATCTGATTATCGGGGTCATT TCAATGAATCTGTTTACGACCTACATCATCATGAATCGATGGGCCTTAGGGAACTTGGCC TGTGACCTCTGGCTTGCCATTGACTACGTAGCCAGCAATGCCTCTGTTATGAATCTTCTG GTCATCAGCTTTGACAGATACTTTTCCATCACGAGGCCGCTCACGTACCGAGCCAAACGA ACAACAAAGAGAGCCGGTGTGATGATCGGTCTGGCTTGGGTCATCTCCTTTGTCCTTTGG GCTCCTGCCATCTTGTTCTGGCAATACTTTGTTGGAAAGAGAACTGTGCCTCCGGGAGAG TGCTTCATTCAGTTCCTCAGTGAGCCCACCATTACTTTTGGCACAGCCATCGCTGCTTTT TATATGCCTGTCACCATTATGACTATTTTATACTGGAGGATCTATAAGGAAACTGAAAAG CGTACCAAAGAGCTTGCTGGCCTGCAAGCCTCTGGGACAGAGGCAGAGACAGAAAACTTT GTCCACCCCACGGGCAGTTCTCGAAGCTGCAGCAGTTACGAACTTCAACAGCAAAGCATG AAACGCTCCAACAGGAGGAAGTATGGCCGCTGCCACTTCTGGTTCACAACCAAGAGCTGG AAACCCAGCTCCGAGCAGATGGACCAAGACCACAGCAGCAGTGACAGTTGGAACAACAAT GATGCTGCTGCCTCCCTGGAGAACTCCGCCTCCTCCGACGAGGAGGACATTGGCTCCGAG ACGAGAGCCATCTACTCCATCGTGCTCAAGCTTCCGGGTCACAGCACCATCCTCAACTCC ACCAAGTTACCCTCATCGGACAACCTGCAGGTGCCTGAGGAGGAGCTGGGGATGGTGGAC TTGGAGAGGAAAGCCGACAAGCTGCAGGCCCAGAAGAGCGTGGACGATGGAGGCAGTTTT CCAAAAAGCTTCTCCAAGCTTCCCATCCAGCTAGAGTCAGCCGTGGACACAGCTAAGACT TCTGACGTCAACTCCTCAGTGGGTAAGAGCACGGCCACTCTACCTCTGTCCTTCAAGGAA GCCACTCTGGCCAAGAGGTTTGCTCTGAAGACCAGAAGTCAGATCACTAAGCGGAAAAGG ATGTCCCTGGTCAAGGAGAAGAAAGCGGCCCAGACCCTCAGTGCGATCTTGCTTGCCTTC ATCATCACTTGGACCCCATACAACATCATGGTTCTGGTGAACACCTTTTGTGACAGCTGC ATACCCAAAACCTTTTGGAATCTGGGCTACTGGCTGTGCTACATCAACAGCACCGTGAAC CCCGTGTGCTATGCTCTGTGCAACAAAACATTCAGAACCACTTTCAAGATGCTGCTGCTG TGCCAGTGTGACAAAAAAAAGAGGCGCAAGCAGCAGTACCAGCAGAGACAGTCGGTCATT TTTCACAAGCGCGCACCCGAGCAGGCCTTGTAG
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentbasolateral plasma membranecomponentcell junctioncomponentdendritecomponentintegral component of plasma membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionacetylcholine bindingfunctiondrug bindingfunctionG-protein coupled acetylcholine receptor activityfunctionphosphatidylinositol phospholipase C activityfunctionreceptor activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocesscellular protein modification processprocessenergy reserve metabolic processprocessG-protein coupled acetylcholine receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessnervous system developmentprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocesspositive regulation of smooth muscle contractionprocessregulation of insulin secretionprocessregulation of vascular smooth muscle contractionprocesssaliva secretionprocesssensory perception of chemical stimulusprocesssignal transductionprocesssmall molecule metabolic processprocesssmooth muscle contractionprocesssynaptic transmission, cholinergic
id:BE0000092
name:Muscarinic acetylcholine receptor M1
organism:Humans
action:agonist
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Fisher A, Heldman E, Gurwitz D, Haring R, Karton Y, Meshulam H, Pittel Z, Marciano D, Brandeis R, Sadot E, Barg Y, Pinkas-Kramarski R, Vogel Z, Ginzburg I, Treves TA, Verchovsky R, Klimowsky S, Korczyn AD: M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update. Ann N Y Acad Sci. 1996 Jan 17;777:189-96.
known-action:yes
name:Muscarinic acetylcholine receptor M1
general-function:Phosphatidylinositol phospholipase c activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
gene-name:CHRM1
locus:11q13
cellular-location:Cell membrane
transmembrane-regions:25-47 62-82 100-121 142-164 187-209 367-387 402-421
signal-regions:
theoretical-pi:9.67
molecular-weight:51420.375
chromosome-location:11
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1950GenAtlasCHRM1GenBank Gene DatabaseX52068GenBank Protein Database34451IUPHAR13Guide to Pharmacology13UniProtKBP11229UniProt AccessionACM1_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0000184|Muscarinic acetylcholine receptor M1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
gene-sequence:>lcl|BSEQ0009929|Muscarinic acetylcholine receptor M1 (CHRM1) ATGAACACTTCAGCCCCACCTGCTGTCAGCCCCAACATCACCGTCCTGGCACCAGGAAAG GGTCCCTGGCAAGTGGCCTTCATTGGGATCACCACGGGCCTCCTGTCGCTAGCCACAGTG ACAGGCAACCTGCTGGTACTCATCTCTTTCAAGGTCAACACGGAGCTCAAGACAGTCAAT AACTACTTCCTGCTGAGCCTGGCCTGTGCTGACCTCATCATCGGTACCTTCTCCATGAAC CTCTATACCACGTACCTGCTCATGGGCCACTGGGCTCTGGGCACGCTGGCTTGTGACCTC TGGCTGGCCCTGGACTATGTGGCCAGCAATGCCTCCGTCATGAATCTGCTGCTCATCAGC TTTGACCGCTACTTCTCCGTGACTCGGCCCCTGAGCTACCGTGCCAAGCGCACACCCCGC CGGGCAGCTCTGATGATCGGCCTGGCCTGGCTGGTTTCCTTTGTGCTCTGGGCCCCAGCC ATCCTCTTCTGGCAGTACCTGGTAGGGGAGCGGACAGTGCTAGCTGGGCAGTGCTACATC CAGTTCCTCTCCCAGCCCATCATCACCTTTGGCACAGCCATGGCTGCCTTCTACCTCCCT GTCACAGTCATGTGCACGCTCTACTGGCGCATCTACCGGGAGACAGAGAACCGAGCACGG GAGCTGGCAGCCCTTCAGGGCTCCGAGACGCCAGGCAAAGGGGGTGGCAGCAGCAGCAGC TCAGAGAGGTCTCAGCCAGGGGCTGAGGGCTCACCAGAGACTCCTCCAGGCCGCTGCTGT CGCTGCTGCCGGGCCCCCAGGCTGCTGCAGGCCTACAGCTGGAAGGAAGAAGAGGAAGAG GACGAAGGCTCCATGGAGTCCCTCACATCCTCAGAGGGAGAGGAGCCTGGCTCCGAAGTG GTGATCAAGATGCCAATGGTGGACCCCGAGGCACAGGCCCCCACCAAGCAGCCCCCACGG AGCTCCCCAAATACAGTCAAGAGGCCGACTAAGAAAGGGCGTGATCGAGCTGGCAAGGGC CAGAAGCCCCGTGGAAAGGAGCAGCTGGCCAAGCGGAAGACCTTCTCGCTGGTCAAGGAG AAGAAGGCGGCTCGGACCCTGAGTGCCATCCTCCTGGCCTTCATCCTCACCTGGACACCG TACAACATCATGGTGCTGGTGTCCACCTTCTGCAAGGACTGTGTTCCCGAGACCCTGTGG GAGCTGGGCTACTGGCTGTGCTACGTCAACAGCACCATCAACCCCATGTGCTACGCACTC TGCAACAAAGCCTTCCGGGACACCTTTCGCCTGCTGCTGCTTTGCCGCTGGGACAAGAGA CGCTGGCGCAAGATCCCCAAGCGCCCTGGCTCCGTGCACCGCACTCCCTCCCGCCAATGC TGA
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentcell junctioncomponentdendritecomponentintegral component of plasma membranecomponentmembranecomponentplasma membranecomponentpostsynaptic densitycomponentpostsynaptic membranecomponentsynapsefunctiondrug bindingfunctionG-protein coupled acetylcholine receptor activityfunctionphosphatidylinositol phospholipase C activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocesscellular protein modification processprocesscognitionprocessentrainment of circadian clockprocessG-protein coupled acetylcholine receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessnervous system developmentprocessneuromuscular synaptic transmissionprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocessphototransduction, visible lightprocesspositive regulation of cell proliferationprocesspositive regulation of intracellular protein transportprocesspositive regulation of ion transportprocessprotein kinase C-activating G-protein coupled receptor signaling pathwayprocessregulation of locomotionprocesssaliva secretionprocesssensory perception of chemical stimulusprocesssignal transductionprocesssynaptic transmission, cholinergic

酶

BE0002363Cytochrome P450 2D6HumanssubstrateA1472611725960Washio T, Arisawa H, Kohsaka K, Yasuda H: Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011. Biol Pharm Bull. 2001 Nov;24(11):1263-6.A1472712608011Washio T, Kohsaka K, Arisawa H, Masunaga H: Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittelforschung. 2003;53(1):26-33.unknownCytochrome P450 2D6Steroid hydroxylase activityResponsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.CYP2D622q13.1Endoplasmic reticulum membrane7.2655768.9422HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2625GenAtlasCYP2D6GenBank Gene DatabaseM20403GenBank Protein Database181350Guide to Pharmacology1329UniProtKBP10635UniProt AccessionCP2D6_HUMAN1.14.14.1Cholesterol 25-hydroxylaseCYP2DL1CYPIID6Cytochrome P450-DB1Debrisoquine 4-hydroxylase>lcl|BSEQ0004641|Cytochrome P450 2D6 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV FAFLVSPSPYELCAVPR>lcl|BSEQ0019275|Cytochrome P450 2D6 (CYP2D6) ATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATAGTGGCCATCTTCCTGCTCCTGGTG GACCTGATGCACCGGCGCCAACGCTGGGCTGCACGCTACCCACCAGGCCCCCTGCCACTG CCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAGAACACACCATACTGCTTCGACCAG TTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTG CTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTGACCCACGGCGAGGACACCGCCGAC CGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTCGGGCCGCGTTCCCAAGGGGTGTTC CTGGCGCGCTATGGGCCCGCGTGGCGCGAGCAGAGGCGCTTCTCCGTGTCCACCTTGCGC AACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTT TGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTTCGCCCCAACGGTCTCTTGGACAAA GCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGGCGCCGCTTCGAGTACGACGACCCT CGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGACTGAAGGAGGAGTCGGGCTTTCTG CGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCATATCCCAGCGCTGGCTGGCAAGGTC CTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGATGAGCTGCTAACTGAGCACAGGATG ACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACTGAGGCCTTCCTGGCAGAGATGGAG AAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGATGAGAACCTGCGCATAGTGGTGGCT GACCTGTTCTCTGCCGGGATGGTGACCACCTCGACCACGCTGGCCTGGGGCCTCCTGCTC ATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAACAGGAGATCGACGACGTGATAGGG CAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCACATGCCCTACACCACTGCCGTGATT CATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTGGGTGTGACCCATATGACATCCCGT GACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGAACGACACTCATCACCAACCTGTCA TCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCCTTCCGCTTCCACCCCGAACACTTC CTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCCTTCCTGCCTTTCTCAGCAGGCCGC CGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAGCTCTTCCTCTTCTTCACCTCCCTG CTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAGCCCCGGCCCAGCCACCATGGTGTC TTTGCTTTCCTGGTGAGCCCATCCCCCTATGAGCTTTGTGCTGTGCCCCGCTAGPF00067p450componentcytoplasmcomponentendoplasmic reticulumcomponentendoplasmic reticulum membranecomponentmitochondrionfunctionarachidonic acid epoxygenase activityfunctionaromatase activityfunctiondrug bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessalkaloid catabolic processprocessalkaloid metabolic processprocessarachidonic acid metabolic processprocesscoumarin metabolic processprocessdrug catabolic processprocessdrug metabolic processprocessexogenous drug catabolic processprocessheterocycle metabolic processprocessisoquinoline alkaloid metabolic processprocessmonoterpenoid metabolic processprocessnegative regulation of bindingprocessnegative regulation of cellular organofluorine metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid metabolic processprocessxenobiotic metabolic processBE0002638Cytochrome P450 3A4HumanssubstrateA1472611725960Washio T, Arisawa H, Kohsaka K, Yasuda H: Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011. Biol Pharm Bull. 2001 Nov;24(11):1263-6.A1472712608011Washio T, Kohsaka K, Arisawa H, Masunaga H: Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittelforschung. 2003;53(1):26-33.unknownCytochrome P450 3A4Vitamin d3 25-hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).CYP3A47q21.1Endoplasmic reticulum membrane2-228.2557342.677HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2637GenAtlasCYP3A4GenBank Gene DatabaseM18907Guide to Pharmacology1337UniProtKBP08684UniProt AccessionCP3A4_HUMAN1,8-cineole 2-exo-monooxygenase1.14.13.-Albendazole monooxygenaseAlbendazole sulfoxidaseCholesterol 25-hydroxylaseCYP3A3CYPIIIA3CYPIIIA4Cytochrome P450 3A3Cytochrome P450 HLpCytochrome P450 NF-25Cytochrome P450-PCN1Nifedipine oxidaseQuinine 3-monooxygenaseTaurochenodeoxycholate 6-alpha-hydroxylase>lcl|BSEQ0021936|Cytochrome P450 3A4 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG GLLQPEKPVVLKVESRDGTVSGA>lcl|BSEQ0021937|Cytochrome P450 3A4 (CYP3A4) ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG CTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG CCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTT GACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCT GTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT GTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATA GCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGA AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGC ATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTT CTCTCAATAATCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTGTTT CCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGCCTC GAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAATTCA AAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATTATC TTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTG GCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAAT AAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAAT GAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTT GAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTT CACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAG AAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAAC TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGAGGA CTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTAAGT GGAGCCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintegral component of membranecomponentintracellular membrane-bounded organellefunctionalbendazole monooxygenase activityfunctionaromatase activityfunctioncaffeine oxidase activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxygen bindingfunctionquinine 3-monooxygenase activityfunctionsteroid bindingfunctionsteroid hydroxylase activityfunctiontaurochenodeoxycholate 6alpha-hydroxylase activityfunctiontestosterone 6-beta-hydroxylase activityfunctionvitamin D 24-hydroxylase activityfunctionvitamin D3 25-hydroxylase activityprocessalkaloid catabolic processprocessandrogen metabolic processprocesscalcitriol biosynthetic process from calciolprocessdrug catabolic processprocessdrug metabolic processprocessexogenous drug catabolic processprocessheterocycle metabolic processprocesslipid metabolic processprocessmonoterpenoid metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid catabolic processprocesssteroid metabolic processprocessvitamin D metabolic processprocessxenobiotic metabolic processBE0003609Dimethylaniline monooxygenase [N-oxide-forming] 1HumanssubstrateA1472611725960Washio T, Arisawa H, Kohsaka K, Yasuda H: Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011. Biol Pharm Bull. 2001 Nov;24(11):1263-6.A1472712608011Washio T, Kohsaka K, Arisawa H, Masunaga H: Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittelforschung. 2003;53(1):26-33.unknownDimethylaniline monooxygenase [N-oxide-forming] 1Nadp bindingThis protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.FMO11q23-q25Microsome membrane7.2260310.2851HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:3769GenBank Gene DatabaseM64082GenBank Protein Database182671UniProtKBQ01740UniProt AccessionFMO1_HUMAN1.14.13.8Dimethylaniline oxidase 1Fetal hepatic flavin-containing monooxygenase 1FMO 1>lcl|BSEQ0006944|Dimethylaniline monooxygenase [N-oxide-forming] 1 MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVS NSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSA VSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPD IFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQ NMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIR PSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAH LQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWF GLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGK WEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL>lcl|BSEQ0019446|Dimethylaniline monooxygenase [N-oxide-forming] 1 (FMO1) ATGCAGGAGAACATGGCCAAGCGAGTTGCCATTGTGGGAGCTGGGGTCAGCGGCCTGGCC TCCATCAAGTGCTGTCTGGAAGAAGGACTGGAGCCCACCTGCTTTGAGAGGAGCGATGAC CTTGGGGGGCTGTGGAGATTCACCGAACATGTTGAAGAAGGCAGAGCCAGTCTCTACAAG TCTGTGGTTTCCAACAGCTGCAAGGAGATGTCTTGTTACTCAGACTTTCCATTCCCAGAA GATTATCCAAACTATGTGCCAAATTCTCAATTCCTGGAATATCTCAAAATGTATGCAAAC CACTTTGACCTTCTGAAACACATTCAATTCAAGACCAAAGTCTGCAGTGTAACAAAATGC TCAGATTCTGCTGTCTCTGGCCAATGGGAGGTGGTCACTATGCATGAAGAGAAGCAAGAG TCAGCCATCTTTGATGCTGTCATGGTCTGCACTGGCTTTCTTACTAATCCTTATTTGCCA CTGGATTCCTTTCCAGGTATTAATGCCTTTAAAGGCCAGTACTTTCATAGCCGGCAATAT AAGCATCCAGATATATTTAAGGACAAGAGAGTCCTTGTGATTGGAATGGGAAATTCTGGC ACAGACATTGCTGTGGAGGCCAGCCACCTGGCGGAAAAGGTGTTCCTCAGCACCACCGGA GGGGGATGGGTGATCAGCCGAATCTTTGACTCGGGCTACCCATGGGACATGGTGTTCATG ACACGCTTTCAGAACATGTTGAGAAATTCCCTCCCAACCCCAATTGTGACTTGGTTGATG GAGCGAAAGATAAACAACTGGCTCAATCATGCAAATTACGGCTTAATACCAGAAGACAGG ACTCAGCTGAAAGAGTTTGTGCTAAATGATGAGCTCCCAGGACGCATCATCACTGGGAAA GTGTTCATCAGGCCAAGCATAAAAGAGGTAAAGGAAAACTCTGTCATATTTAACAATACT TCAAAGGAAGAGCCTATTGACATCATTGTCTTTGCCACTGGATACACATTTGCTTTCCCC TTCCTTGATGAGTCTGTAGTGAAAGTTGAAGATGGCCAGGCCTCACTGTACAAGTATATC TTCCCTGCACATCTGCAAAAGCCAACCCTGGCCATTATTGGCCTCATCAAACCCTTGGGC TCCATGATACCTACAGGAGAAACACAAGCTCGGTGGGCTGTTCGAGTCCTGAAAGGTGTA AATAAGTTACCACCACCAAGTGTCATGATAGAGGAAATTAATGCAAGGAAAGAAAACAAG CCCAGTTGGTTTGGCTTGTGCTACTGCAAGGCTTTACAATCAGATTATATCACATACATA GATGAACTCCTGACCTATATCAATGCAAAACCCAACCTGTTCTCTATGCTCCTAACGGAT CCACATCTGGCTCTGACCGTCTTCTTTGGCCCATGCTCACCATACCAGTTCCGCTTGACT GGCCCAGGAAAATGGGAAGGAGCCAGAAATGCCATCATGACCCAGTGGGACCGAACATTC AAGGTCATCAAAGCTCGAGTTGTACAAGAGTCTCCATCTCCCTTTGAAAGTTTTCTTAAA GTCTTTAGCTTTCTGGCTTTGCTTGTGGCTATTTTTCTGATTTTCCTATAAPF00743FMO-likecomponentendoplasmic reticulum lumencomponentendoplasmic reticulum membranecomponentintegral component of membranefunctionflavin adenine dinucleotide bindingfunctionmonooxygenase activityfunctionN,N-dimethylaniline monooxygenase activityfunctionNADP bindingprocessdrug metabolic processprocessNADPH oxidationprocessorganic acid metabolic processprocessresponse to lipopolysaccharideprocessresponse to osmotic stressprocesssmall molecule metabolic processprocesstoxin metabolic processprocessxenobiotic metabolic process

载体

运输工具

药物反应

reactions:1
left-element--drugbank-id:DB00185
left-element--name:Cevimeline
right-element--drugbank-id:DBMET00430
right-element--name:cevimeline trans-sulfoxide
enzymes--drugbank-id:BE0002638
enzymes--name:Cytochrome P450 3A4
enzymes--uniprot-id:P08684
enzymes--drugbank-id:BE0002363
enzymes--name:Cytochrome P450 2D6
enzymes--uniprot-id:P10635
reactions:1
left-element--drugbank-id:DB00185
left-element--name:Cevimeline
right-element--drugbank-id:DBMET00431
right-element--name:cevimeline cis-sulfoxide
enzymes--drugbank-id:BE0002638
enzymes--name:Cytochrome P450 3A4
enzymes--uniprot-id:P08684
reactions:1
left-element--drugbank-id:DB00185
left-element--name:Cevimeline
right-element--drugbank-id:DBMET00432
right-element--name:cevimeline cis-sulfoxidation
enzymes--drugbank-id:BE0002363
enzymes--name:Cytochrome P450 2D6
enzymes--uniprot-id:P10635
reactions:1
left-element--drugbank-id:DB00185
left-element--name:Cevimeline
right-element--drugbank-id:DBMET00433
right-element--name:cevimeline N-oxide
enzymes--drugbank-id:BE0003609
enzymes--name:Dimethylaniline monooxygenase [N-oxide-forming] 1
enzymes--uniprot-id:Q01740
reactions:1
left-element--drugbank-id:DB00185
left-element--name:Cevimeline
right-element--drugbank-id:DBMET00488
right-element--name:Glucuronic acid

效应

不良反应