ID
DB00191|APRD00093||
名称
Phentermine
描述
Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential).[A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373]
cas号
122-09-8
唯一标识码
C045TQL4WP
状态
solid
一般参考文献
Johnson DB, Quick J: Topiramate And Phentermine .
Ryder JR, Kaizer A, Rudser KD, Gross A, Kelly AS, Fox CK: Effect of phentermine on weight reduction in a pediatric weight management clinic. Int J Obes (Lond). 2017 Jan;41(1):90-93. doi: 10.1038/ijo.2016.185. Epub 2016 Oct 24.
Kiortsis DN: A review of the metabolic effects of controlled-release Phentermine/Topiramate. Hormones (Athens). 2013 Oct-Dec;12(4):507-16.
Garvey WT: Phentermine and topiramate extended-release: a new treatment for obesity and its role in a complications-centric approach to obesity medical management. Expert Opin Drug Saf. 2013 Sep;12(5):741-56. doi: 10.1517/14740338.2013.806481. Epub 2013 Jun 6.
Bersoux S, Byun TH, Chaliki SS, Poole KG: Pharmacotherapy for obesity: What you need to know. Cleve Clin J Med. 2017 Dec;84(12):951-958. doi: 10.3949/ccjm.84a.16094.
Weigle DS: Pharmacological therapy of obesity: past, present, and future. J Clin Endocrinol Metab. 2003 Jun;88(6):2462-9. doi: 10.1210/jc.2003-030151.
Adebonojo FO: Primary exogenous obesity. A conceptual classification. Clin Pediatr (Phila). 1974 Sep;13(9):715-8. doi: 10.1177/000992287401300901.
May S. (2009). Weight-Loss Drugs. Chelsea House Publishers.
Barceloux D.G. (2012). Medical toxicology of drug abuse: Synthesized chemicals and psychoactive plants.. Wiley.
T403978-1-60413-204-5May S. (2009). Weight-Loss Drugs. Chelsea House Publishers.T49Barceloux D.G. (2012). Medical toxicology of drug abuse: Synthesized chemicals and psychoactive plants.. Wiley.
EmpowerPharmacy
https://www.empowerpharmacy.com/drugs/phentermine-hcl-capsules.html
Inchem
http://www.inchem.org/documents/pims/pharm/pim415.htm#SectionTitle:6.5%20%20Elimination%20and%20excretion
FDA reports
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202088Orig1s000PharmR.pdf
QSYMIA (phentermine/topiramate) FDA label
//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/283/original/fda.pdf?1549057509
F3283QSYMIA (phentermine/topiramate) FDA label//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/283/original/fda.pdf?1549057509
approved,illicit,
指示
Phentermine is indicated, alone or in combination with topiramate, as a short-term adjunct, not pass a few weeks, in a regimen of weight reduction based on exercise, behavioral modifications and caloric restriction in the management of exogenous obesity for patients with an initial body mass index (BMI) greater than 30 kg/m2 or greater than 27 kg/m2 in presence of other risk factors such as controller hypertension, diabetes or hyperlipidemia.[FDA label] Exogenous obesity is considered when the overweight is caused by consuming more food than the person activity level warrants. This condition commonly causes an increase in fat storage. It is an epidemic condition in the United States where over two-thirds of adults are overweight or obese and one in three Americans is obese. In the world, the incidence of obesity has nearly doubled.[A174391]
药效学
It is reported that the main mechanism of action of phentermine is the generation of appetite suppression, maybe due to the increase in leptin, but it is considered that other mechanisms should be involved.[A174370] Some reports have indicated that the weight loss effect is mainly due to the increase in resting energy expenditure.[A174367] In clinical studies where phentermine was used as a monotherapy and as combination therapy, this drug has shown an average weight loss of 3.6 kg when compared with the placebo in 2-24 weeks. Patients treated with phentermine also showed increased maintenance of the weight after treatment discontinuation.[A174367] As well, even though it is a derivative of the amphetamines, it has not been registered to produce any of the effects of amphetamine such as central nervous system stimulation, elevation of blood pressure, tachyphylaxis or QTc prolongation.[A174370]
作用机制
Phentermine is an indirect-acting sympathomimetic agent that acts by releasing noradrenaline from the presynaptic vesicles in the lateral hypothalamus. This increase in noradrenaline concentration in the synaptic cleft results in the stimulation of beta2-adrenergic receptors.[A174367] Phentermine is classified as an indirect sympathomimetic due to the increase in the level of norepinephrine, dopamine and its indirect effect towards serotonin.[L5233] Some reports have indicated that phentermine inhibits the neuropeptide Y which is a principal signaling pathway for the induction of hunger.[T403] This combined effect produces a continuous flight-or-fight response in the body which reduces the hunger signal as this state is on the immediate need for energy.[T403] Lastly, some reports have indicated that phentermine is a weak inhibitor of monoamine oxidase but this mechanism does not tend to produce a clinically significant response.[T49]
毒性
The reported LD50 after oral administration of phentermine in rats is reported to be of 151 mg/kg.[L5239] Reports of acute overdose include restlessness, tremors, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations and panic state followed by fatigue, and depression. In the cardiovascular system, there are reports of tachycardia, arrhythmia, hypertension, hypotension, circulatory collapse. In the GI tract, there are symptoms of nausea, vomiting, diarrhea and abdominal cramps. The management of acute overdosage includes symptomatic treatment as well as lavage and sedation with barbiturates.[FDA label] On the other hand, chronic overdosage is marked by dermatoses, insomnia, irritability, hyperactivity and personality changes. In severe cases, it can derive into a schizophrenia-like psychosis.[FDA label] Studies regarding the carcinogenic potential have not been performed. On the case of mutagenic assays, phentermine was shown to not be mutagenic nor clastogenic.[FDA label]
代谢
Phentermine undergoes minimal p-hydroxylation, N-oxidation and N-hydroxylation followed by conjugation. The total proportion of the drug that goes under metabolism only represents about 6% of the administered dose where about 5% is represented by the N-oxidized and N-Hydroxylated metabolites.[T49]
吸收
Phentermine shows a dose-dependent pharmacokinetic profile. After oral administration of a dose of 15 mg, the maximal concentration was achieved after 6 hours and its bioavailability was not affected by the consumption of high-fat meals.[A174370] The reported plasma concentration at steady-state is of around 200 ng/ml as observed in clinical trials.[T49]
半衰期
The mean terminal half-life of phentermine is reported to be of approximately 20 hours.[A174370] In conditions where there is acidic urine (pH <5), the elimination half-life is of 7-8 hours.[T49]
分类
description:This compound belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
direct-parent:Amphetamines and derivatives
kingdom:Organic compounds
superclass:Benzenoids
class:Benzene and substituted derivatives
subclass:Phenethylamines
alternative-parent:Aralkylamines
alternative-parent:Hydrocarbon derivatives
alternative-parent:Monoalkylamines
alternative-parent:Organopnictogen compounds
alternative-parent:Phenylpropanes
substituent:Amine
substituent:Amphetamine or derivatives
substituent:Aralkylamine
substituent:Aromatic homomonocyclic compound
substituent:Hydrocarbon derivative
substituent:Organic nitrogen compound
substituent:Organonitrogen compound
substituent:Organopnictogen compound
substituent:Phenylpropane
substituent:Primary aliphatic amine
substituent:Primary amine
消除途径
Phentermine is excreted mainly in the urine from which about 70-80% of the administered dose can be found as the unchanged drug.[A174370]
种类
Adrenergic Agents
D018663
Agents producing tachycardia

Agents that produce hypertension

Alimentary Tract and Metabolism

Amines
D000588
Amphetamines
D000662
Anti-Obesity Agents
D019440
Antiobesity Preparations, Excl. Diet Products

Appetite Depressants
D001067
Appetite Suppression

Autonomic Agents
D001337
Central Nervous System Agents
D002491
Centrally Acting Antiobesity Products

Cytochrome P-450 CYP3A Substrates

Cytochrome P-450 CYP3A4 Substrates

Cytochrome P-450 CYP3A4 Substrates (strength unknown)

Cytochrome P-450 Substrates

Increased Sympathetic Activity

Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates

Neurotransmitter Agents
D018377
Peripheral Nervous System Agents
D018373
Phenethylamines
D010627
Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
D020230
Sympathomimetic Amine Anorectic

Sympathomimetics
D013566
盐类
DBSALT000138Phentermine hydrochloride0K2I505OTV1197-21-3NCAIGTHBQTXTLR-UHFFFAOYSA-N185.694185.097127224
蛋白质结合
The protein binding of phentermine is determined to be of 17.5%.[A174370]
清除
The reported clearance when administered orally is 8.79 L/h as observed in pharmacokinetic population studies.[F3283]
同义词
language:english; code:; name;alpha,alpha-Dimethylphenethylamine
language:spanish; code:inn; name;Fentermina
language:english; code:inn/usan; name;Phentermine
language:english; code:; name;Phentermine resin
language:latin; code:inn; name;Phenterminum
国际品牌
DapexFernidale LabsDuromineiNova PharmaceuticalsFastinHi-Tech PharmaceuticalsObenixJones PharmaObestin-30Fernidale LabsOby-trimRexarPhentercotTruven Health Analytics IncPhentrideTruven Health Analytics IncUmi-PexFernidale Labs
配送量
The reported volume of distribution for phentermine is reported to be of 5 L/kg.[L5236]
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name:Phentermine Hydrochloride
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name:Phentermine Hydrochloride
labeller:Actavis Totowa LLC
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name:Phentermine Hydrochloride
labeller:A-S Medication Solutions
ndc-id:
ndc-product-code:50090-0119
dpd-id:
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ended-marketing-on:2017-04-30
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA040886
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:A-S Medication Solutions
ndc-id:
ndc-product-code:50090-0416
dpd-id:
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strength:30 mg/1
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country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:A-S Medication Solutions
ndc-id:
ndc-product-code:50090-0536
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country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:Unit Dose Services
ndc-id:
ndc-product-code:50436-6743
dpd-id:
ema-product-code:
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started-marketing-on:2012-08-15
ended-marketing-on:2017-12-31
dosage-form:Capsule
strength:37.5 mg/1
route:Oral
fda-application-number:ANDA040887
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:Lake Erie Medical DBA Quality Care Products LLC
ndc-id:
ndc-product-code:55700-117
dpd-id:
ema-product-code:
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started-marketing-on:2012-08-07
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dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA040886
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:Preferred Pharmaceuticals, Inc.
ndc-id:
ndc-product-code:68788-6767
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2012-07-25
ended-marketing-on:2019-02-19
dosage-form:Tablet
strength:37.5 mg/1
route:Oral
fda-application-number:ANDA200272
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:Direct Rx
ndc-id:
ndc-product-code:72189-071
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2020-06-17
ended-marketing-on:
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strength:30 mg/1
route:Oral
fda-application-number:ANDA087022
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:Proficient Rx LP
ndc-id:
ndc-product-code:63187-144
dpd-id:
ema-product-code:
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started-marketing-on:2013-08-12
ended-marketing-on:2015-09-01
dosage-form:Tablet
strength:30 mg/1
route:Oral
fda-application-number:ANDA040526
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:bryant ranch prepack
ndc-id:
ndc-product-code:63629-1106
dpd-id:
ema-product-code:
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strength:30 mg/1
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fda-application-number:ANDA040526
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:bryant ranch prepack
ndc-id:
ndc-product-code:63629-1108
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fda-application-number:ANDA040526
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over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:bryant ranch prepack
ndc-id:
ndc-product-code:63629-1107
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2020-06-17
ended-marketing-on:
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strength:30 mg/1
route:Oral
fda-application-number:ANDA040526
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:Preferred Pharmaceuticals, Inc.
ndc-id:
ndc-product-code:68788-7740
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2020-07-01
ended-marketing-on:
dosage-form:Capsule
strength:15 mg/1
route:Oral
fda-application-number:ANDA205019
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine hydrochloride
labeller:Asclemed Usa, Inc.
ndc-id:
ndc-product-code:76420-108
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2017-01-24
ended-marketing-on:
dosage-form:Tablet
strength:37.5 mg/1
route:Oral
fda-application-number:ANDA205008
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Hydrochloride
labeller:Preferred Pharmaceuticals Inc.
ndc-id:
ndc-product-code:68788-7823
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2020-11-20
ended-marketing-on:
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strength:37.5 mg/1
route:Oral
fda-application-number:ANDA040876
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Resin ER
labeller:Lannett Company, Inc.
ndc-id:
ndc-product-code:0527-1398
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2011-07-28
ended-marketing-on:
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strength:15 mg/1
route:Oral
fda-application-number:ANDA040872
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phentermine Resin ER
labeller:Lannett Company, Inc.
ndc-id:
ndc-product-code:0527-1366
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2011-07-28
ended-marketing-on:
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strength:30 mg/1
route:Oral
fda-application-number:ANDA040872
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Phetermine Hydrochloride
labeller:Actavis Pharma Company
ndc-id:
ndc-product-code:0228-3016
dpd-id:
ema-product-code:
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started-marketing-on:2009-01-21
ended-marketing-on:2015-07-31
dosage-form:Tablet
strength:37.5 mg/1
route:Oral
fda-application-number:ANDA040276
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Qsymia
labeller:VIVUS, Inc.
ndc-id:
ndc-product-code:62541-201
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2012-09-17
ended-marketing-on:
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strength:
route:Oral
fda-application-number:NDA022580
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Qsymia
labeller:VIVUS, Inc.
ndc-id:
ndc-product-code:62541-202
dpd-id:
ema-product-code:
ema-ma-number:
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country:US
source:FDA NDC
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ndc-id:
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dpd-id:
ema-product-code:
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strength:
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over-the-counter:false
approved:true
country:US
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name:Qsymia
labeller:VIVUS, Inc.
ndc-id:
ndc-product-code:62541-203
dpd-id:
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started-marketing-on:2012-09-17
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fda-application-number:NDA022580
generic:false
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country:US
source:FDA NDC
name:Suprenza
labeller:Akrimax Pharmaceuticals, LLC
ndc-id:
ndc-product-code:24090-722
dpd-id:
ema-product-code:
ema-ma-number:
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ended-marketing-on:2018-09-30
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country:US
source:FDA NDC
name:Suprenza
labeller:Akrimax Pharmaceuticals, LLC
ndc-id:
ndc-product-code:24090-721
dpd-id:
ema-product-code:
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country:US
source:FDA NDC
name:Suprenza
labeller:Akrimax Pharmaceuticals, LLC
ndc-id:
ndc-product-code:24090-720
dpd-id:
ema-product-code:
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fda-application-number:NDA202088
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source:FDA NDC
混合物
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Ionamin
ingredients:Phentermine
name:Ionamin
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine HCl
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine HCl
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phetermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine HCl
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Resin ER
ingredients:Phentermine
name:Phentermine Resin ER
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Suprenza
ingredients:Phentermine
name:Suprenza
ingredients:Phentermine
name:Suprenza
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Lomaira
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine
ingredients:Phentermine
name:Phentermine
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine
ingredients:Phentermine
name:Phentermine
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine HCl C-IV
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Lomaira
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Qsymia
ingredients:Phentermine + Topiramate
name:Qsymia
ingredients:Phentermine + Topiramate
name:Qsymia
ingredients:Phentermine + Topiramate
name:Qsymia
ingredients:Phentermine + Topiramate
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Phentermine
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Phentermine hydrochloride
ingredients:Phentermine
name:Phentermine Hydrochloride
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Adipex-P
ingredients:Phentermine
name:Ionamin
ingredients:Phentermine
name:Ionamin
ingredients:Phentermine
name:Fastin Cap 30mg
ingredients:Phentermine
包装者
name:Apotheca Inc.
url:
name:A-S Medication Solutions LLC
url:http://orders.a-smeds.com
name:Blenheim Pharmacal
url:http://www.bpipack.com
name:Bryant Ranch Prepack
url:http://bryantranchprepack.com
name:C.O. Truxton Inc.
url:
name:Calvin Scott and Co. Inc.
url:http://www.calvinscottinc.com
name:Caraco Pharmaceutical Labs
url:http://www.caraco.com
name:Carlisle Laboratories Inc.
url:
name:Corepharma LLC
url:http://www.corepharma.com
name:Darby Dental Supply Co. Inc.
url:http://www.darbydental.com
name:DispenseXpress Inc.
url:
name:Dispensing Solutions
url:http://www.drxdispensing.com
name:Diversified Healthcare Services Inc.
url:http://www.dhscorp.com
name:EMS Acquisition Corp.
url:http://www.emsdiasum.com
name:Eon Labs
url:
name:Gate Pharmaceuticals
url:
name:H.J. Harkins Co. Inc.
url:http://hjharkinscompanyinc.com
name:Keltman Pharmaceuticals Inc.
url:http://www.keltman.com
name:Kraft Pharmaceutical Co. Inc.
url:
name:KVK-Tech Inc.
url:http://www.kvktech.com
name:Lake Erie Medical and Surgical Supply
url:
name:Lannett Co. Inc.
url:http://www.lannett.com
name:Macnary Ltd.
url:
name:Major Pharmaceuticals
url:http://www.majorpharmaceuticals.com
name:MCR American Pharmaceuticals Inc.
url:http://www.mcramerican.com
name:Medisca Inc.
url:http://www.medisca.com
name:Mutual Pharmaceutical Co.
url:
name:Nucare Pharmaceuticals Inc.
url:http://www.nucarerx.com
name:Palmetto Pharmaceuticals Inc.
url:http://www.palmettopharm.com
name:PCA LLC
url:
name:PD-Rx Pharmaceuticals Inc.
url:http://www.pdrx.com
name:Pharma Pac LLC
url:http://www.pharmapacllc.com
name:Physicians Total Care Inc.
url:http://www.physicianstotalcare.com
name:Preferred Pharmaceuticals Inc.
url:http://www.preferredpharmaceuticals.com
name:Prepak Systems Inc.
url:http://www.prepaksys.com
name:Prescript Pharmaceuticals
url:http://www.prescript.net
name:Qualitest
url:http://www.worldoftest.com
name:Quality Research Pharmaceutical Inc.
url:
name:Rebel Distributors Corp.
url:http://www.rebelrx.com
name:Redpharm Drug
url:
name:Southwood Pharmaceuticals
url:http://www.southwoodhealthcare.com
name:Stat Rx Usa
url:http://statrxusa.exporterus.com
name:Superior Pharmeceuticals
url:
name:Teva Pharmaceutical Industries Ltd.
url:http://www.tevapharm.com
name:UCB Pharma
url:http://www.ucb.com
name:United Research Laboratories Inc.
url:http://www.urlpharma.com
name:Vintage Pharmaceuticals Inc.
url:
生产者
generic:否; url:; name;Baxter healthcare corp anesthesia critical care
generic:否; url:; name;Teva pharmaceuticals usa inc
generic:否; url:; name;Glaxosmithkline
generic:否; url:; name;Ferndale laboratories inc
generic:否; url:; name;Shire richwood inc
generic:否; url:; name;Mm mast and co
generic:是; url:; name;Abc holding corp
generic:是; url:; name;Able laboratories inc
generic:是; url:; name;Actavis totowa llc
generic:是; url:; name;Barr laboratories inc
generic:是; url:; name;Camall co inc
generic:是; url:; name;Duramed pharmaceuticals inc sub barr laboratories inc
generic:是; url:; name;Ivax pharmaceuticals inc
generic:是; url:; name;Kvk tech inc
generic:是; url:; name;Lannett co inc
generic:是; url:; name;Lannett holdings inc
generic:是; url:; name;Mutual pharmaceutical co inc
generic:是; url:; name;Sandoz inc
generic:是; url:; name;Tg united inc
generic:是; url:; name;Tg united labs llc
generic:是; url:; name;Usl pharma inc
generic:是; url:; name;Vitarine pharmaceuticals inc
generic:是; url:; name;Watson laboratories inc
generic:是; url:; name;Actavis elizabeth llc
generic:是; url:; name;Caraco pharmaceutical laboratories ltd
generic:是; url:; name;Vintage pharmaceuticals inc
generic:否; url:; name;Solvay pharmaceuticals
generic:否; url:; name;Ucb inc
generic:否; url:; name;Quantum pharmics ltd
价格
Phentermine HCl 37.5 mg capsule
1.0(单位:USD)
capsule
Phentermine HCl 37.5 mg tablet
1.0(单位:USD)
tablet
Ionamin 15 mg capsule sa
1.15(单位:USD)
capsule
Phentermine HCl 30 mg capsule
1.17(单位:USD)
capsule
Phentermine HCl 15 mg capsule
1.18(单位:USD)
capsule
Phentermine 37.5 mg tablet
1.54(单位:USD)
tablet
Adipex-p 37.5 mg tablet
2.15(单位:USD)
tablet
Adipex-P 37.5 mg capsule
2.2(单位:USD)
capsule
Ionamin 30 mg capsule sa
2.87(单位:USD)
capsule
Phentermine hcl powder
10.71(单位:USD)
g
Phentermine 8 mg tablet
0.54(单位:USD)
tablet
受影响的生物体
Humans and other mammals
剂量
form:Tablet
route:Oral
strength:30 MG
form:Capsule
route:Oral
strength:
form:Tablet
route:Oral
strength:8 mg/1
form:Capsule
route:Oral
strength:15 mg
form:Capsule
route:Oral
strength:30 mg
form:Capsule
route:Oral
strength:15 mg/1
form:Capsule
route:Oral
strength:30 mg/1
form:Capsule
route:Oral
strength:37.5 mg/1
form:Tablet
route:Oral
strength:30 mg/1
form:Tablet
route:Oral
strength:37.5 mg/1
form:Capsule, extended release
route:Oral
strength:15 mg/1
form:Capsule, extended release
route:Oral
strength:30 mg/1
form:Capsule, extended release
route:Oral
strength:
form:Tablet, orally disintegrating
route:Oral
strength:15 mg/1
form:Tablet, orally disintegrating
route:Oral
strength:30 mg/1
form:Tablet, orally disintegrating
route:Oral
strength:37.5 mg/1
atc代码
Centrally acting antiobesity products
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
ALIMENTARY TRACT AND METABOLISM
fda标签
//s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00191.pdf?1548977468
化学品安全技术说明书
//s3-us-west-2.amazonaws.com/drugbank/msds/DB00191.pdf?1265922741
专利
number:6071537
country:United States
approved:2000-06-06
expires:2017-06-23
pediatric-extension:否
number:8895057
country:United States
approved:2014-11-25
expires:2028-06-09
pediatric-extension:否
number:7056890
country:United States
approved:2006-06-06
expires:2020-06-14
pediatric-extension:否
number:7553818
country:United States
approved:2009-06-30
expires:2020-06-14
pediatric-extension:否
number:7659256
country:United States
approved:2010-02-09
expires:2020-06-14
pediatric-extension:否
number:7674776
country:United States
approved:2010-03-09
expires:2020-06-14
pediatric-extension:否
number:8580299
country:United States
approved:2013-11-12
expires:2029-06-14
pediatric-extension:否
number:9011906
country:United States
approved:2015-04-21
expires:2028-06-09
pediatric-extension:否
number:9011905
country:United States
approved:2015-04-21
expires:2028-06-09
pediatric-extension:否
number:8895058
country:United States
approved:2014-11-25
expires:2028-06-09
pediatric-extension:否
number:8580298
country:United States
approved:2013-11-12
expires:2029-05-15
pediatric-extension:否
number:6149938
country:United States
approved:2000-11-21
expires:2018-07-23
pediatric-extension:否
number:8440170
country:United States
approved:2013-05-14
expires:2029-03-14
pediatric-extension:否
食物相互作用
Limit caffeine intake.Take with or without food. The absorption is unaffected by food.
药物相互作用
DB00177
Phentermine may decrease the antihypertensive activities of Valsartan.
DB00178
Phentermine may decrease the antihypertensive activities of Ramipril.
DB00212
Phentermine may decrease the antihypertensive activities of Remikiren.
DB00214
Phentermine may decrease the antihypertensive activities of Torasemide.
DB00275
Phentermine may decrease the antihypertensive activities of Olmesartan.
DB00310
Phentermine may decrease the antihypertensive activities of Chlorthalidone.
DB00325
Phentermine may decrease the antihypertensive activities of Nitroprusside.
DB00350
Phentermine may decrease the antihypertensive activities of Minoxidil.
DB00374
Phentermine may decrease the antihypertensive activities of Treprostinil.
DB00436
Phentermine may decrease the antihypertensive activities of Bendroflumethiazide.
DB00492
Phentermine may decrease the antihypertensive activities of Fosinopril.
DB00519
Phentermine may decrease the antihypertensive activities of Trandolapril.
DB00524
Phentermine may decrease the antihypertensive activities of Metolazone.
DB00542
Phentermine may decrease the antihypertensive activities of Benazepril.
DB00584
Phentermine may decrease the antihypertensive activities of Enalapril.
DB00606
Phentermine may decrease the antihypertensive activities of Cyclothiazide.
DB00616
Phentermine may decrease the antihypertensive activities of Candoxatril.
DB00629
Phentermine may decrease the antihypertensive activities of Guanabenz.
DB00657
Phentermine may decrease the antihypertensive activities of Mecamylamine.
DB00691
Phentermine may decrease the antihypertensive activities of Moexipril.
DB00722
Phentermine may decrease the antihypertensive activities of Lisinopril.
DB00727
Phentermine may decrease the antihypertensive activities of Nitroglycerin.
DB00765
Phentermine may decrease the antihypertensive activities of Metyrosine.
DB00774
Phentermine may decrease the antihypertensive activities of Hydroflumethiazide.
DB00785
Phentermine may decrease the antihypertensive activities of Cryptenamine.
DB00790
Phentermine may decrease the antihypertensive activities of Perindopril.
DB00796
Phentermine may decrease the antihypertensive activities of Candesartan cilexetil.
DB00800
Phentermine may decrease the antihypertensive activities of Fenoldopam.
DB00876
Phentermine may decrease the antihypertensive activities of Eprosartan.
DB00880
Phentermine may decrease the antihypertensive activities of Chlorothiazide.
DB00881
Phentermine may decrease the antihypertensive activities of Quinapril.
DB00966
Phentermine may decrease the antihypertensive activities of Telmisartan.
DB00968
Phentermine may decrease the antihypertensive activities of Methyldopa.
DB00999
Phentermine may decrease the antihypertensive activities of Hydrochlorothiazide.
DB01021
Phentermine may decrease the antihypertensive activities of Trichlormethiazide.
DB01089
Phentermine may decrease the antihypertensive activities of Deserpidine.
DB01090
Phentermine may decrease the antihypertensive activities of Pentolinium.
DB01116
Phentermine may decrease the antihypertensive activities of Trimethaphan.
DB01119
Phentermine may decrease the antihypertensive activities of Diazoxide.
DB01197
Phentermine may decrease the antihypertensive activities of Captopril.
DB01240
Phentermine may decrease the antihypertensive activities of Epoprostenol.
DB01324
Phentermine may decrease the antihypertensive activities of Polythiazide.
DB01340
Phentermine may decrease the antihypertensive activities of Cilazapril.
DB01347
Phentermine may decrease the antihypertensive activities of Saprisartan.
DB01348
Phentermine may decrease the antihypertensive activities of Spirapril.
DB04831
Phentermine may decrease the antihypertensive activities of Tienilic acid.
DB04840
Phentermine may decrease the antihypertensive activities of Debrisoquine.
DB06445
Phentermine may decrease the antihypertensive activities of Diethylnorspermine.
DB07767
Phentermine may decrease the antihypertensive activities of Ferulic acid.
DB08836
Phentermine may decrease the antihypertensive activities of Temocapril.
DB08960
Phentermine may decrease the antihypertensive activities of Hexamethonium.
DB09220
Phentermine may decrease the antihypertensive activities of Nicorandil.
DB09363
Phentermine may decrease the antihypertensive activities of Rauwolfia serpentina root.
DB09477
Phentermine may decrease the antihypertensive activities of Enalaprilat.
DB11720
Phentermine may decrease the antihypertensive activities of Angiotensin 1-7.
DB11783
Phentermine may decrease the antihypertensive activities of Imidapril.
DB12054
Phentermine may decrease the antihypertensive activities of BQ-123.
DB12766
Phentermine may decrease the antihypertensive activities of Cicletanine.
DB12945
Phentermine may decrease the antihypertensive activities of Dihydralazine.
DB13166
Phentermine may decrease the antihypertensive activities of Zofenopril.
DB13211
Phentermine may decrease the antihypertensive activities of Guanoxan.
DB13312
Phentermine may decrease the antihypertensive activities of Delapril.
DB13374
Phentermine may decrease the antihypertensive activities of Vincamine.
DB13400
Phentermine may decrease the antihypertensive activities of Linsidomine.
DB13410
Phentermine may decrease the antihypertensive activities of Guanoxabenz.
DB13429
Phentermine may decrease the antihypertensive activities of Tolonidine.
DB13435
Phentermine may decrease the antihypertensive activities of Endralazine.
DB13452
Phentermine may decrease the antihypertensive activities of Cadralazine.
DB13532
Phentermine may decrease the antihypertensive activities of Cyclopenthiazide.
DB13575
Phentermine may decrease the antihypertensive activities of Bietaserpine.
DB13604
Phentermine may decrease the antihypertensive activities of Guanazodine.
DB13631
Phentermine may decrease the antihypertensive activities of Methoserpidine.
DB13779
Phentermine may decrease the antihypertensive activities of Guanoclor.
DB13801
Phentermine may decrease the antihypertensive activities of Muzolimine.
DB13803
Phentermine may decrease the antihypertensive activities of Xipamide.
DB13919
Phentermine may decrease the antihypertensive activities of Candesartan.
DB14094
Phentermine may decrease the antihypertensive activities of Tocopherylquinone.
DB14125
Phentermine may decrease the antihypertensive activities of Benazeprilat.
DB14207
Phentermine may decrease the antihypertensive activities of Fosinoprilat.
DB14208
Phentermine may decrease the antihypertensive activities of Ramiprilat.
DB14213
Phentermine may decrease the antihypertensive activities of Perindoprilat.
DB14217
Phentermine may decrease the antihypertensive activities of Quinaprilat.
DB00695
Phentermine may decrease the antihypertensive activities of Furosemide.
DB00381
Phentermine may decrease the antihypertensive activities of Amlodipine.
DB00393
Phentermine may decrease the antihypertensive activities of Nimodipine.
DB00528
Phentermine may decrease the antihypertensive activities of Lercanidipine.
DB00808
Phentermine may decrease the antihypertensive activities of Indapamide.
DB01018
Phentermine may decrease the antihypertensive activities of Guanfacine.
DB01054
Phentermine may decrease the antihypertensive activities of Nitrendipine.
DB01244
Phentermine may decrease the antihypertensive activities of Bepridil.
DB06403
Phentermine may decrease the antihypertensive activities of Ambrisentan.
DB06762
Phentermine may decrease the antihypertensive activities of Pinacidil.
DB08931
Phentermine may decrease the antihypertensive activities of Riociguat.
DB08932
Phentermine may decrease the antihypertensive activities of Macitentan.
DB09026
Phentermine may decrease the antihypertensive activities of Aliskiren.
DB09236
Phentermine may decrease the antihypertensive activities of Lacidipine.
DB11362
Phentermine may decrease the antihypertensive activities of Selexipag.
DB14068
Phentermine may decrease the antihypertensive activities of Dexniguldipine.
DB00820
Phentermine may decrease the antihypertensive activities of Tadalafil.
DB00401
Phentermine may decrease the antihypertensive activities of Nisoldipine.
DB00700
Phentermine may decrease the antihypertensive activities of Eplerenone.
DB09237
Phentermine may decrease the antihypertensive activities of Levamlodipine.
DB00289
The risk or severity of hypertension can be increased when Atomoxetine is combined with Phentermine.
DB00593
Phentermine can cause a decrease in the absorption of Ethosuximide resulting in a reduced serum concentration and potentially a decrease in efficacy.
DB08824
Phentermine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
DB00601
The risk or severity of hypertension can be increased when Linezolid is combined with Phentermine.
DB00794
The serum concentration of Primidone can be decreased when it is combined with Phentermine.
DB00849
The serum concentration of Methylphenobarbital can be decreased when it is combined with Phentermine.
DB01174
The serum concentration of Phenobarbital can be decreased when it is combined with Phentermine.
DB00252
The therapeutic efficacy of Phenytoin can be decreased when used in combination with Phentermine.
DB01320
The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Phentermine.
DB00035
The risk or severity of hypertension can be increased when Desmopressin is combined with Phentermine.
DB00159
The risk or severity of hypertension can be increased when Icosapent is combined with Phentermine.
DB00217
The risk or severity of hypertension can be increased when Phentermine is combined with Bethanidine.
DB00221
The risk or severity of hypertension can be increased when Phentermine is combined with Isoetharine.
DB00244
The risk or severity of hypertension can be increased when Phentermine is combined with Mesalazine.
DB00292
The risk or severity of hypertension can be increased when Phentermine is combined with Etomidate.
DB00328
The risk or severity of hypertension can be increased when Phentermine is combined with Indomethacin.
DB00422
The risk or severity of hypertension can be increased when Phentermine is combined with Methylphenidate.
DB00461
The risk or severity of hypertension can be increased when Phentermine is combined with Nabumetone.
DB00465
The risk or severity of hypertension can be increased when Phentermine is combined with Ketorolac.
DB00469
The risk or severity of hypertension can be increased when Phentermine is combined with Tenoxicam.
DB00500
The risk or severity of hypertension can be increased when Phentermine is combined with Tolmetin.
DB00554
The risk or severity of hypertension can be increased when Phentermine is combined with Piroxicam.
DB00561
The risk or severity of hypertension can be increased when Phentermine is combined with Doxapram.
DB00572
The risk or severity of hypertension can be increased when Phentermine is combined with Atropine.
DB00573
The risk or severity of hypertension can be increased when Phentermine is combined with Fenoprofen.
DB00605
The risk or severity of hypertension can be increased when Phentermine is combined with Sulindac.
DB00633
The risk or severity of hypertension can be increased when Phentermine is combined with Dexmedetomidine.
DB00712
The risk or severity of hypertension can be increased when Phentermine is combined with Flurbiprofen.
DB00749
The risk or severity of hypertension can be increased when Phentermine is combined with Etodolac.
DB00753
The risk or severity of hypertension can be increased when Phentermine is combined with Isoflurane.
DB00784
The risk or severity of hypertension can be increased when Phentermine is combined with Mefenamic acid.
DB00788
The risk or severity of hypertension can be increased when Phentermine is combined with Naproxen.
DB00795
The risk or severity of hypertension can be increased when Phentermine is combined with Sulfasalazine.
DB00818
The risk or severity of hypertension can be increased when Phentermine is combined with Propofol.
DB00821
The risk or severity of hypertension can be increased when Phentermine is combined with Carprofen.
DB00861
The risk or severity of hypertension can be increased when Phentermine is combined with Diflunisal.
DB00886
The risk or severity of hypertension can be increased when Phentermine is combined with Omapatrilat.
DB00901
The risk or severity of hypertension can be increased when Phentermine is combined with Bitolterol.
DB00936
The risk or severity of hypertension can be increased when Phentermine is combined with Salicylic acid.
DB00939
The risk or severity of hypertension can be increased when Phentermine is combined with Meclofenamic acid.
DB00945
The risk or severity of hypertension can be increased when Phentermine is combined with Acetylsalicylic acid.
DB00983
The risk or severity of hypertension can be increased when Phentermine is combined with Formoterol.
DB00991
The risk or severity of hypertension can be increased when Phentermine is combined with Oxaprozin.
DB01009
The risk or severity of hypertension can be increased when Phentermine is combined with Ketoprofen.
DB01014
The risk or severity of hypertension can be increased when Phentermine is combined with Balsalazide.
DB01102
The risk or severity of hypertension can be increased when Phentermine is combined with Arbutamine.
DB01180
The risk or severity of hypertension can be increased when Phentermine is combined with Rescinnamine.
DB01189
The risk or severity of hypertension can be increased when Phentermine is combined with Desflurane.
DB01250
The risk or severity of hypertension can be increased when Phentermine is combined with Olsalazine.
DB01274
The risk or severity of hypertension can be increased when Phentermine is combined with Arformoterol.
DB01283
The risk or severity of hypertension can be increased when Phentermine is combined with Lumiracoxib.
DB01291
The risk or severity of hypertension can be increased when Phentermine is combined with Pirbuterol.
DB01363
The risk or severity of hypertension can be increased when Phentermine is combined with Ephedra sinica root.
DB01397
The risk or severity of hypertension can be increased when Phentermine is combined with Magnesium salicylate.
DB01399
The risk or severity of hypertension can be increased when Phentermine is combined with Salsalate.
DB01401
The risk or severity of hypertension can be increased when Phentermine is combined with Choline magnesium trisalicylate.
DB01408
The risk or severity of hypertension can be increased when Phentermine is combined with Bambuterol.
DB01419
The risk or severity of hypertension can be increased when Phentermine is combined with Antrafenine.
DB01472
The risk or severity of hypertension can be increased when Phentermine is combined with 4-Methoxyamphetamine.
DB01579
The risk or severity of hypertension can be increased when Phentermine is combined with Phendimetrazine.
DB01600
The risk or severity of hypertension can be increased when Phentermine is combined with Tiaprofenic acid.
DB02032
The risk or severity of hypertension can be increased when Phentermine is combined with Epicaptopril.
DB02224
The risk or severity of hypertension can be increased when Phentermine is combined with Taxifolin.
DB03585
The risk or severity of hypertension can be increased when Phentermine is combined with Oxyphenbutazone.
DB04812
The risk or severity of hypertension can be increased when Phentermine is combined with Benoxaprofen.
DB05095
The risk or severity of hypertension can be increased when Phentermine is combined with Cimicoxib.
DB05395
The risk or severity of hypertension can be increased when Phentermine is combined with Amibegron.
DB05562
The risk or severity of hypertension can be increased when Phentermine is combined with Naluzotan.
DB06190
The risk or severity of hypertension can be increased when Phentermine is combined with Solabegron.
DB06690
The risk or severity of hypertension can be increased when Phentermine is combined with Nitrous oxide.
DB06694
The risk or severity of hypertension can be increased when Phentermine is combined with Xylometazoline.
DB06706
The risk or severity of hypertension can be increased when Phentermine is combined with Isometheptene.
DB06711
The risk or severity of hypertension can be increased when Phentermine is combined with Naphazoline.
DB06725
The risk or severity of hypertension can be increased when Phentermine is combined with Lornoxicam.
DB06736
The risk or severity of hypertension can be increased when Phentermine is combined with Aceclofenac.
DB06737
The risk or severity of hypertension can be increased when Phentermine is combined with Zaltoprofen.
DB06763
The risk or severity of hypertension can be increased when Phentermine is combined with Saralasin.
DB07402
The risk or severity of hypertension can be increased when Phentermine is combined with Azapropazone.
DB08797
The risk or severity of hypertension can be increased when Phentermine is combined with Salicylamide.
DB08925
The risk or severity of hypertension can be increased when Phentermine is combined with Adrafinil.
DB08940
The risk or severity of hypertension can be increased when Phentermine is combined with Kebuzone.
DB08942
The risk or severity of hypertension can be increased when Phentermine is combined with Isoxicam.
DB08951
The risk or severity of hypertension can be increased when Phentermine is combined with Indoprofen.
DB08955
The risk or severity of hypertension can be increased when Phentermine is combined with Ibuproxam.
DB08957
The risk or severity of hypertension can be increased when Phentermine is combined with Hexoprenaline.
DB08976
The risk or severity of hypertension can be increased when Phentermine is combined with Floctafenine.
DB08981
The risk or severity of hypertension can be increased when Phentermine is combined with Fenbufen.
DB08984
The risk or severity of hypertension can be increased when Phentermine is combined with Etofenamate.
DB08991
The risk or severity of hypertension can be increased when Phentermine is combined with Epirizole.
DB09080
The risk or severity of hypertension can be increased when Phentermine is combined with Olodaterol.
DB09084
The risk or severity of hypertension can be increased when Phentermine is combined with Benzydamine.
DB09202
The risk or severity of hypertension can be increased when Phentermine is combined with Cirazoline.
DB09213
The risk or severity of hypertension can be increased when Phentermine is combined with Dexibuprofen.
DB09215
The risk or severity of hypertension can be increased when Phentermine is combined with Droxicam.
DB09217
The risk or severity of hypertension can be increased when Phentermine is combined with Firocoxib.
DB09218
The risk or severity of hypertension can be increased when Phentermine is combined with Clonixin.
DB09242
The risk or severity of hypertension can be increased when Phentermine is combined with Moxonidine.
DB09285
The risk or severity of hypertension can be increased when Phentermine is combined with Morniflumate.
DB09295
The risk or severity of hypertension can be increased when Phentermine is combined with Talniflumate.
DB11278
The risk or severity of hypertension can be increased when Phentermine is combined with DL-Methylephedrine.
DB11373
The risk or severity of hypertension can be increased when Phentermine is combined with Amitraz.
DB11428
The risk or severity of hypertension can be increased when Phentermine is combined with Medetomidine.
DB11455
The risk or severity of hypertension can be increased when Phentermine is combined with Robenacoxib.
DB11466
The risk or severity of hypertension can be increased when Phentermine is combined with Tepoxalin.
DB11477
The risk or severity of hypertension can be increased when Phentermine is combined with Xylazine.
DB11518
The risk or severity of hypertension can be increased when Phentermine is combined with Flunixin.
DB11541
The risk or severity of hypertension can be increased when Phentermine is combined with Ractopamine.
DB11543
The risk or severity of hypertension can be increased when Phentermine is combined with Romifidine.
DB11556
The risk or severity of hypertension can be increased when Phentermine is combined with Detomidine.
DB11587
The risk or severity of hypertension can be increased when Phentermine is combined with Etafedrine.
DB11738
The risk or severity of hypertension can be increased when Phentermine is combined with Rilmenidine.
DB11755
The risk or severity of hypertension can be increased when Phentermine is combined with Tetrahydrocannabivarin.
DB11871
The risk or severity of hypertension can be increased when Phentermine is combined with PF-00610355.
DB12100
The risk or severity of hypertension can be increased when Phentermine is combined with Abediterol.
DB12248
The risk or severity of hypertension can be increased when Phentermine is combined with Tulobuterol.
DB12313
The risk or severity of hypertension can be increased when Phentermine is combined with Dopexamine.
DB12361
The risk or severity of hypertension can be increased when Phentermine is combined with Piclozotan.
DB12445
The risk or severity of hypertension can be increased when Phentermine is combined with Nitroaspirin.
DB12545
The risk or severity of hypertension can be increased when Phentermine is combined with Indobufen.
DB12610
The risk or severity of hypertension can be increased when Phentermine is combined with Ebselen.
DB12779
The risk or severity of hypertension can be increased when Phentermine is combined with Higenamine.
DB12846
The risk or severity of hypertension can be increased when Phentermine is combined with Reproterol.
DB13001
The risk or severity of hypertension can be increased when Phentermine is combined with Tinoridine.
DB13167
The risk or severity of hypertension can be increased when Phentermine is combined with Alclofenac.
DB13217
The risk or severity of hypertension can be increased when Phentermine is combined with Fentiazac.
DB13232
The risk or severity of hypertension can be increased when Phentermine is combined with Suxibuzone.
DB13251
The risk or severity of hypertension can be increased when Phentermine is combined with Octopamine.
DB13286
The risk or severity of hypertension can be increased when Phentermine is combined with Bumadizone.
DB13314
The risk or severity of hypertension can be increased when Phentermine is combined with Alminoprofen.
DB13323
The risk or severity of hypertension can be increased when Phentermine is combined with Trichloroethylene.
DB13371
The risk or severity of hypertension can be increased when Phentermine is combined with Difenpiramide.
DB13378
The risk or severity of hypertension can be increased when Phentermine is combined with Norfenefrine.
DB13398
The risk or severity of hypertension can be increased when Phentermine is combined with Oxyfedrine.
DB13407
The risk or severity of hypertension can be increased when Phentermine is combined with Nifenazone.
DB13432
The risk or severity of hypertension can be increased when Phentermine is combined with Lonazolac.
DB13453
The risk or severity of hypertension can be increased when Phentermine is combined with Xenon.
DB13481
The risk or severity of hypertension can be increased when Phentermine is combined with Tenidap.
DB13520
The risk or severity of hypertension can be increased when Phentermine is combined with Metergoline.
DB13524
The risk or severity of hypertension can be increased when Phentermine is combined with Propyphenazone.
DB13527
The risk or severity of hypertension can be increased when Phentermine is combined with Proglumetacin.
DB13538
The risk or severity of hypertension can be increased when Phentermine is combined with Guacetisal.
DB13544
The risk or severity of hypertension can be increased when Phentermine is combined with Ethenzamide.
DB13559
The risk or severity of hypertension can be increased when Phentermine is combined with Rimiterol.
DB13598
The risk or severity of hypertension can be increased when Phentermine is combined with Diethyl ether.
DB13612
The risk or severity of hypertension can be increased when Phentermine is combined with Carbaspirin calcium.
DB13629
The risk or severity of hypertension can be increased when Phentermine is combined with Mofebutazone.
DB13649
The risk or severity of hypertension can be increased when Phentermine is combined with Proquazone.
DB13657
The risk or severity of hypertension can be increased when Phentermine is combined with Benorilate.
DB13722
The risk or severity of hypertension can be increased when Phentermine is combined with Pirprofen.
DB13781
The risk or severity of hypertension can be increased when Phentermine is combined with Xamoterol.
DB13783
The risk or severity of hypertension can be increased when Phentermine is combined with Acemetacin.
DB13860
The risk or severity of hypertension can be increased when Phentermine is combined with Imidazole salicylate.
DB14059
The risk or severity of hypertension can be increased when Phentermine is combined with SC-236.
DB14060
The risk or severity of hypertension can be increased when Phentermine is combined with NS-398.
DB14231
The risk or severity of hypertension can be increased when Phentermine is combined with Quinoline Yellow WS.
DB09214
The risk or severity of hypertension can be increased when Phentermine is combined with Dexketoprofen.
DB00482
The risk or severity of hypertension can be increased when Phentermine is combined with Celecoxib.
DB00580
The risk or severity of hypertension can be increased when Phentermine is combined with Valdecoxib.
DB00586
The risk or severity of hypertension can be increased when Phentermine is combined with Diclofenac.
DB00814
The risk or severity of hypertension can be increased when Phentermine is combined with Meloxicam.
DB00938
The risk or severity of hypertension can be increased when Phentermine is combined with Salmeterol.
DB01001
The risk or severity of hypertension can be increased when Phentermine is combined with Salbutamol.
DB01028
The risk or severity of hypertension can be increased when Phentermine is combined with Methoxyflurane.
DB01050
The risk or severity of hypertension can be increased when Phentermine is combined with Ibuprofen.
DB01159
The risk or severity of hypertension can be increased when Phentermine is combined with Halothane.
DB01236
The risk or severity of hypertension can be increased when Phentermine is combined with Sevoflurane.
DB01424
The risk or severity of hypertension can be increased when Phentermine is combined with Aminophenazone.
DB01435
The risk or severity of hypertension can be increased when Phentermine is combined with Antipyrine.
DB01591
The risk or severity of hypertension can be increased when Phentermine is combined with Solifenacin.
DB04743
The risk or severity of hypertension can be increased when Phentermine is combined with Nimesulide.
DB04828
The risk or severity of hypertension can be increased when Phentermine is combined with Zomepirac.
DB05039
The risk or severity of hypertension can be increased when Phentermine is combined with Indacaterol.
DB08439
The risk or severity of hypertension can be increased when Phentermine is combined with Parecoxib.
DB08893
The risk or severity of hypertension can be increased when Phentermine is combined with Mirabegron.
DB09082
The risk or severity of hypertension can be increased when Phentermine is combined with Vilanterol.
DB09216
The risk or severity of hypertension can be increased when Phentermine is combined with Tolfenamic acid.
DB09288
The risk or severity of hypertension can be increased when Phentermine is combined with Propacetamol.
DB13139
The risk or severity of hypertension can be increased when Phentermine is combined with Levosalbutamol.
DB13399
The risk or severity of hypertension can be increased when Phentermine is combined with Terguride.
DB15685
The risk or severity of hypertension can be increased when Phentermine is combined with Selpercatinib.
DB01216
The risk or severity of hypertension can be increased when Phentermine is combined with Finasteride.
DB09212
The risk or severity of hypertension can be increased when Phentermine is combined with Loxoprofen.
DB15965
The risk or severity of hypertension can be increased when Phentermine is combined with Naxitamab.
DB09042
Tedizolid phosphate may increase the hypertensive activities of Phentermine.
DB00370
Phentermine may increase the serotonergic activities of Mirtazapine.
DB00295
Phentermine may increase the analgesic activities of Morphine.
DB00318
Phentermine may increase the analgesic activities of Codeine.
DB00327
Phentermine may increase the analgesic activities of Hydromorphone.
DB00333
Phentermine may increase the analgesic activities of Methadone.
DB00497
Phentermine may increase the analgesic activities of Oxycodone.
DB00611
Phentermine may increase the analgesic activities of Butorphanol.
DB00647
Phentermine may increase the analgesic activities of Dextropropoxyphene.
DB00652
Phentermine may increase the analgesic activities of Pentazocine.
DB00704
Phentermine may increase the analgesic activities of Naltrexone.
DB00708
Phentermine may increase the analgesic activities of Sufentanil.
DB00844
Phentermine may increase the analgesic activities of Nalbuphine.
DB00854
Phentermine may increase the analgesic activities of Levorphanol.
DB00899
Phentermine may increase the analgesic activities of Remifentanil.
DB00921
Phentermine may increase the analgesic activities of Buprenorphine.
DB01081
Phentermine may increase the analgesic activities of Diphenoxylate.
DB01192
Phentermine may increase the analgesic activities of Oxymorphone.
DB01209
Phentermine may increase the analgesic activities of Dezocine.
DB01433
Phentermine may increase the analgesic activities of Methadyl acetate.
DB01450
Phentermine may increase the analgesic activities of Dihydroetorphine.
DB01452
Phentermine may increase the analgesic activities of Diamorphine.
DB01459
Phentermine may increase the analgesic activities of Bezitramide.
DB01466
Phentermine may increase the analgesic activities of Ethylmorphine.
DB01497
Phentermine may increase the analgesic activities of Etorphine.
DB01529
Phentermine may increase the analgesic activities of Dextromoramide.
DB01531
Phentermine may increase the analgesic activities of Desomorphine.
DB01535
Phentermine may increase the analgesic activities of Carfentanil.
DB01551
Phentermine may increase the analgesic activities of Dihydrocodeine.
DB01555
Phentermine may increase the analgesic activities of Alphacetylmethadol.
DB01565
Phentermine may increase the analgesic activities of Dihydromorphine.
DB06204
Phentermine may increase the analgesic activities of Tapentadol.
DB06738
Phentermine may increase the analgesic activities of Ketobemidone.
DB08861
Phentermine may increase the analgesic activities of DPDPE.
DB09174
Phentermine may increase the analgesic activities of Lofentanil.
DB09272
Phentermine may increase the analgesic activities of Eluxadoline.
DB11130
Phentermine may increase the analgesic activities of Opium.
DB11609
Phentermine may increase the analgesic activities of Normethadone.
DB12492
Phentermine may increase the analgesic activities of Piritramide.
DB13160
Phentermine may increase the analgesic activities of Alphaprodine.
DB13454
Phentermine may increase the analgesic activities of Nicomorphine.
DB13478
Phentermine may increase the analgesic activities of Meptazinol.
DB13605
Phentermine may increase the analgesic activities of Phenoperidine.
DB13606
Phentermine may increase the analgesic activities of Phenazocine.
DB13787
Phentermine may increase the analgesic activities of Tilidine.
DB15360
Phentermine may increase the analgesic activities of Carfentanil, C-11.
DB15465
Phentermine may increase the analgesic activities of Benzhydrocodone.
DB00802
Phentermine may increase the analgesic activities of Alfentanil.
DB00813
Phentermine may increase the analgesic activities of Fentanyl.
DB00245
Phentermine may decrease the sedative and stimulatory activities of Benzatropine.
DB00283
Phentermine may decrease the sedative and stimulatory activities of Clemastine.
DB00341
Phentermine may decrease the sedative and stimulatory activities of Cetirizine.
DB00342
Phentermine may decrease the sedative and stimulatory activities of Terfenadine.
DB00354
Phentermine may decrease the sedative and stimulatory activities of Buclizine.
DB00366
Phentermine may decrease the sedative and stimulatory activities of Doxylamine.
DB00405
Phentermine may decrease the sedative and stimulatory activities of Dexbrompheniramine.
DB00427
Phentermine may decrease the sedative and stimulatory activities of Triprolidine.
DB00434
Phentermine may decrease the sedative and stimulatory activities of Cyproheptadine.
DB00455
Phentermine may decrease the sedative and stimulatory activities of Loratadine.
DB00501
Phentermine may decrease the sedative and stimulatory activities of Cimetidine.
DB00557
Phentermine may decrease the sedative and stimulatory activities of Hydroxyzine.
DB00568
Phentermine may decrease the sedative and stimulatory activities of Cinnarizine.
DB00585
Phentermine may decrease the sedative and stimulatory activities of Nizatidine.
DB00637
Phentermine may decrease the sedative and stimulatory activities of Astemizole.
DB00719
Phentermine may decrease the sedative and stimulatory activities of Azatadine.
DB00737
Phentermine may decrease the sedative and stimulatory activities of Meclizine.
DB00748
Phentermine may decrease the sedative and stimulatory activities of Carbinoxamine.
DB00767
Phentermine may decrease the sedative and stimulatory activities of Benzquinamide.
DB00792
Phentermine may decrease the sedative and stimulatory activities of Tripelennamine.
DB00835
Phentermine may decrease the sedative and stimulatory activities of Brompheniramine.
DB00863
Phentermine may decrease the sedative and stimulatory activities of Ranitidine.
DB00902
Phentermine may decrease the sedative and stimulatory activities of Methdilazine.
DB00920
Phentermine may decrease the sedative and stimulatory activities of Ketotifen.
DB00927
Phentermine may decrease the sedative and stimulatory activities of Famotidine.
DB00934
Phentermine may decrease the sedative and stimulatory activities of Maprotiline.
DB00940
Phentermine may decrease the sedative and stimulatory activities of Methantheline.
DB00950
Phentermine may decrease the sedative and stimulatory activities of Fexofenadine.
DB00967
Phentermine may decrease the sedative and stimulatory activities of Desloratadine.
DB00972
Phentermine may decrease the sedative and stimulatory activities of Azelastine.
DB00985
Phentermine may decrease the sedative and stimulatory activities of Dimenhydrinate.
DB01069
Phentermine may decrease the sedative and stimulatory activities of Promethazine.
DB01071
Phentermine may decrease the sedative and stimulatory activities of Mequitazine.
DB01075
Phentermine may decrease the sedative and stimulatory activities of Diphenhydramine.
DB01114
Phentermine may decrease the sedative and stimulatory activities of Chlorpheniramine.
DB01146
Phentermine may decrease the sedative and stimulatory activities of Diphenylpyraline.
DB01151
Phentermine may decrease the sedative and stimulatory activities of Desipramine.
DB01173
Phentermine may decrease the sedative and stimulatory activities of Orphenadrine.
DB01176
Phentermine may decrease the sedative and stimulatory activities of Cyclizine.
DB01239
Phentermine may decrease the sedative and stimulatory activities of Chlorprothixene.
DB01246
Phentermine may decrease the sedative and stimulatory activities of Alimemazine.
DB01615
Phentermine may decrease the sedative and stimulatory activities of Aceprometazine.
DB01619
Phentermine may decrease the sedative and stimulatory activities of Phenindamine.
DB01620
Phentermine may decrease the sedative and stimulatory activities of Pheniramine.
DB03255
Phentermine may decrease the sedative and stimulatory activities of Phenol.
DB04819
Phentermine may decrease the sedative and stimulatory activities of Methapyrilene.
DB04837
Phentermine may decrease the sedative and stimulatory activities of Clofedanol.
DB04841
Phentermine may decrease the sedative and stimulatory activities of Flunarizine.
DB06016
Phentermine may decrease the sedative and stimulatory activities of Cariprazine.
DB06282
Phentermine may decrease the sedative and stimulatory activities of Levocetirizine.
DB06691
Phentermine may decrease the sedative and stimulatory activities of Mepyramine.
DB06698
Phentermine may decrease the sedative and stimulatory activities of Betahistine.
DB08799
Phentermine may decrease the sedative and stimulatory activities of Antazoline.
DB08800
Phentermine may decrease the sedative and stimulatory activities of Chloropyramine.
DB08801
Phentermine may decrease the sedative and stimulatory activities of Dimetindene.
DB08802
Phentermine may decrease the sedative and stimulatory activities of Isothipendyl.
DB08805
Phentermine may decrease the sedative and stimulatory activities of Metiamide.
DB08806
Phentermine may decrease the sedative and stimulatory activities of Roxatidine acetate.
DB08936
Phentermine may decrease the sedative and stimulatory activities of Chlorcyclizine.
DB08967
Phentermine may decrease the sedative and stimulatory activities of Dimetotiazine.
DB09016
Phentermine may decrease the sedative and stimulatory activities of Butriptyline.
DB09167
Phentermine may decrease the sedative and stimulatory activities of Dosulepin.
DB09488
Phentermine may decrease the sedative and stimulatory activities of Acrivastine.
DB09555
Phentermine may decrease the sedative and stimulatory activities of Dexchlorpheniramine maleate.
DB11235
Phentermine may decrease the sedative and stimulatory activities of Thonzylamine.
DB11591
Phentermine may decrease the sedative and stimulatory activities of Bilastine.
DB11614
Phentermine may decrease the sedative and stimulatory activities of Rupatadine.
DB11742
Phentermine may decrease the sedative and stimulatory activities of Ebastine.
DB12523
Phentermine may decrease the sedative and stimulatory activities of Mizolastine.
DB12770
Phentermine may decrease the sedative and stimulatory activities of Lafutidine.
DB12806
Phentermine may decrease the sedative and stimulatory activities of GSK-1004723.
DB12877
Phentermine may decrease the sedative and stimulatory activities of Oxatomide.
DB12884
Phentermine may decrease the sedative and stimulatory activities of Lavoltidine.
DB13466
Phentermine may decrease the sedative and stimulatory activities of Deptropine.
DB13679
Phentermine may decrease the sedative and stimulatory activities of Dexchlorpheniramine.
DB13711
Phentermine may decrease the sedative and stimulatory activities of Tritoqualine.
DB13713
Phentermine may decrease the sedative and stimulatory activities of Quifenadine.
DB13760
Phentermine may decrease the sedative and stimulatory activities of Niperotidine.
DB15120
Phentermine may decrease the sedative and stimulatory activities of GSK-239512.
DB15192
Phentermine may decrease the sedative and stimulatory activities of ABT-288.
DB00246
Phentermine may decrease the sedative and stimulatory activities of Ziprasidone.
DB00321
Phentermine may decrease the sedative and stimulatory activities of Amitriptyline.
DB00334
Phentermine may decrease the sedative and stimulatory activities of Olanzapine.
DB00363
Phentermine may decrease the sedative and stimulatory activities of Clozapine.
DB00420
Phentermine may decrease the sedative and stimulatory activities of Promazine.
DB00458
Phentermine may decrease the sedative and stimulatory activities of Imipramine.
DB00540
Phentermine may decrease the sedative and stimulatory activities of Nortriptyline.
DB00543
Phentermine may decrease the sedative and stimulatory activities of Amoxapine.
DB00726
Phentermine may decrease the sedative and stimulatory activities of Trimipramine.
DB00734
Phentermine may decrease the sedative and stimulatory activities of Risperidone.
DB00777
Phentermine may decrease the sedative and stimulatory activities of Propiomazine.
DB01142
Phentermine may decrease the sedative and stimulatory activities of Doxepin.
DB01224
Phentermine may decrease the sedative and stimulatory activities of Quetiapine.
DB01238
Phentermine may decrease the sedative and stimulatory activities of Aripiprazole.
DB01403
Phentermine may decrease the sedative and stimulatory activities of Methotrimeprazine.
DB01624
Phentermine may decrease the sedative and stimulatory activities of Zuclopenthixol.
DB04946
Phentermine may decrease the sedative and stimulatory activities of Iloperidone.
DB06148
Phentermine may decrease the sedative and stimulatory activities of Mianserin.
DB06153
Phentermine may decrease the sedative and stimulatory activities of Pizotifen.
DB06216
Phentermine may decrease the sedative and stimulatory activities of Asenapine.
DB06678
Phentermine may decrease the sedative and stimulatory activities of Esmirtazapine.
DB14185
Phentermine may decrease the sedative and stimulatory activities of Aripiprazole lauroxil.
DB00751
Phentermine may decrease the sedative and stimulatory activities of Epinastine.
DB01084
Phentermine may decrease the sedative and stimulatory activities of Emedastine.
DB04890
Phentermine may decrease the sedative and stimulatory activities of Bepotastine.
DB09007
Phentermine may decrease the sedative and stimulatory activities of Chlorphenoxamine.
DB00201
The risk or severity of adverse effects can be increased when Phentermine is combined with Caffeine.
DB00651
The risk or severity of adverse effects can be increased when Phentermine is combined with Dyphylline.
DB00806
The risk or severity of adverse effects can be increased when Phentermine is combined with Pentoxifylline.
DB01033
The risk or severity of adverse effects can be increased when Phentermine is combined with Mercaptopurine.
DB01303
The risk or severity of adverse effects can be increased when Phentermine is combined with Oxtriphylline.
DB01412
The risk or severity of adverse effects can be increased when Phentermine is combined with Theobromine.
DB01482
The risk or severity of adverse effects can be increased when Phentermine is combined with Fenethylline.
DB01667
The risk or severity of adverse effects can be increased when Phentermine is combined with 8-azaguanine.
DB01978
The risk or severity of adverse effects can be increased when Phentermine is combined with 7,9-Dimethylguanine.
DB02134
The risk or severity of adverse effects can be increased when Phentermine is combined with Xanthine.
DB02245
The risk or severity of adverse effects can be increased when Phentermine is combined with 7-Deazaguanine.
DB02377
The risk or severity of adverse effects can be increased when Phentermine is combined with Guanine.
DB02489
The risk or severity of adverse effects can be increased when Phentermine is combined with 9-Methylguanine.
DB02568
The risk or severity of adverse effects can be increased when Phentermine is combined with Peldesine.
DB04076
The risk or severity of adverse effects can be increased when Phentermine is combined with Hypoxanthine.
DB04356
The risk or severity of adverse effects can be increased when Phentermine is combined with 9-Deazaguanine.
DB06479
The risk or severity of adverse effects can be increased when Phentermine is combined with Propentofylline.
DB06575
The risk or severity of adverse effects can be increased when Phentermine is combined with Valomaciclovir.
DB07954
The risk or severity of adverse effects can be increased when Phentermine is combined with 3-isobutyl-1-methyl-7H-xanthine.
DB08844
The risk or severity of adverse effects can be increased when Phentermine is combined with Uric acid.
DB09273
The risk or severity of adverse effects can be increased when Phentermine is combined with Doxofylline.
DB11919
The risk or severity of adverse effects can be increased when Phentermine is combined with 6-O-benzylguanine.
DB12406
The risk or severity of adverse effects can be increased when Phentermine is combined with Lisofylline.
DB12531
The risk or severity of adverse effects can be increased when Phentermine is combined with Lobucavir.
DB12926
The risk or severity of adverse effects can be increased when Phentermine is combined with Cafedrine.
DB13203
The risk or severity of adverse effects can be increased when Phentermine is combined with Bamifylline.
DB13449
The risk or severity of adverse effects can be increased when Phentermine is combined with Proxyphylline.
DB13573
The risk or severity of adverse effects can be increased when Phentermine is combined with Acefylline.
DB13592
The risk or severity of adverse effects can be increased when Phentermine is combined with Etamiphylline.
DB13634
The risk or severity of adverse effects can be increased when Phentermine is combined with Pentifylline.
DB13812
The risk or severity of adverse effects can be increased when Phentermine is combined with Bufylline.
DB14018
The risk or severity of adverse effects can be increased when Phentermine is combined with Bromotheophylline.
DB14029
The risk or severity of adverse effects can be increased when Phentermine is combined with Furafylline.
DB14132
The risk or severity of adverse effects can be increased when Phentermine is combined with 8-chlorotheophylline.
DB15122
The risk or severity of adverse effects can be increased when Phentermine is combined with PCS-499.
DB06704
Phentermine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
DB06799
The serum concentration of Phentermine can be decreased when it is combined with Methenamine.
DB00898
The risk or severity of cardiotoxicity can be increased when Ethanol is combined with Phentermine.
DB09241
Phentermine may increase the serotonergic activities of Methylene blue.
DB00126
The serum concentration of Phentermine can be decreased when it is combined with Ascorbic acid.
DB00372
Thiethylperazine may decrease the stimulatory activities of Phentermine.
DB00391
Sulpiride may decrease the stimulatory activities of Phentermine.
DB00409
Remoxipride may decrease the stimulatory activities of Phentermine.
DB00433
Prochlorperazine may decrease the stimulatory activities of Phentermine.
DB00508
Triflupromazine may decrease the stimulatory activities of Phentermine.
DB00623
Fluphenazine may decrease the stimulatory activities of Phentermine.
DB00680
Moricizine may decrease the stimulatory activities of Phentermine.
DB00850
Perphenazine may decrease the stimulatory activities of Phentermine.
DB00933
Mesoridazine may decrease the stimulatory activities of Phentermine.
DB01063
Acetophenazine may decrease the stimulatory activities of Phentermine.
DB01618
Molindone may decrease the stimulatory activities of Phentermine.
DB01621
Pipotiazine may decrease the stimulatory activities of Phentermine.
DB01623
Thiothixene may decrease the stimulatory activities of Phentermine.
DB04872
Osanetant may decrease the stimulatory activities of Phentermine.
DB04888
Bifeprunox may decrease the stimulatory activities of Phentermine.
DB05687
BL-1020 may decrease the stimulatory activities of Phentermine.
DB06077
Lumateperone may decrease the stimulatory activities of Phentermine.
DB06288
Amisulpride may decrease the stimulatory activities of Phentermine.
DB08922
Perospirone may decrease the stimulatory activities of Phentermine.
DB08927
Amperozide may decrease the stimulatory activities of Phentermine.
DB09000
Cyamemazine may decrease the stimulatory activities of Phentermine.
DB09224
Melperone may decrease the stimulatory activities of Phentermine.
DB09226
Brilaroxazine may decrease the stimulatory activities of Phentermine.
DB11376
Azaperone may decrease the stimulatory activities of Phentermine.
DB11540
Propiopromazine may decrease the stimulatory activities of Phentermine.
DB12093
Tetrahydropalmatine may decrease the stimulatory activities of Phentermine.
DB12273
Ecopipam may decrease the stimulatory activities of Phentermine.
DB12401
Bromperidol may decrease the stimulatory activities of Phentermine.
DB12518
Raclopride may decrease the stimulatory activities of Phentermine.
DB12693
Ritanserin may decrease the stimulatory activities of Phentermine.
DB12710
Perazine may decrease the stimulatory activities of Phentermine.
DB12867
Benperidol may decrease the stimulatory activities of Phentermine.
DB12958
Prothipendyl may decrease the stimulatory activities of Phentermine.
DB13025
Tiapride may decrease the stimulatory activities of Phentermine.
DB13213
Butaperazine may decrease the stimulatory activities of Phentermine.
DB13256
Clothiapine may decrease the stimulatory activities of Phentermine.
DB13273
Sultopride may decrease the stimulatory activities of Phentermine.
DB13382
Chlorproethazine may decrease the stimulatory activities of Phentermine.
DB13403
Oxypertine may decrease the stimulatory activities of Phentermine.
DB13420
Thiazinam may decrease the stimulatory activities of Phentermine.
DB13523
Veralipride may decrease the stimulatory activities of Phentermine.
DB13552
Trifluperidol may decrease the stimulatory activities of Phentermine.
DB13554
Moperone may decrease the stimulatory activities of Phentermine.
DB13557
Thiopropazate may decrease the stimulatory activities of Phentermine.
DB13665
Fluanisone may decrease the stimulatory activities of Phentermine.
DB13676
Mosapramine may decrease the stimulatory activities of Phentermine.
DB13784
Dixyrazine may decrease the stimulatory activities of Phentermine.
DB13791
Penfluridol may decrease the stimulatory activities of Phentermine.
DB13841
Clopenthixol may decrease the stimulatory activities of Phentermine.
DB14651
Perphenazine enanthate may decrease the stimulatory activities of Phentermine.
DB01356
Lithium cation may decrease the stimulatory activities of Phentermine.
DB00211
The risk or severity of adverse effects can be increased when Phentermine is combined with Midodrine.
DB00397
The risk or severity of adverse effects can be increased when Phentermine is combined with Phenylpropanolamine.
DB00610
The risk or severity of adverse effects can be increased when Phentermine is combined with Metaraminol.
DB00723
The risk or severity of adverse effects can be increased when Phentermine is combined with Methoxamine.
DB00816
The risk or severity of adverse effects can be increased when Phentermine is combined with Orciprenaline.
DB00830
The risk or severity of adverse effects can be increased when Phentermine is combined with Phenmetrazine.
DB00841
The risk or severity of adverse effects can be increased when Phentermine is combined with Dobutamine.
DB00867
The risk or severity of adverse effects can be increased when Phentermine is combined with Ritodrine.
DB00871
The risk or severity of adverse effects can be increased when Phentermine is combined with Terbutaline.
DB00935
The risk or severity of adverse effects can be increased when Phentermine is combined with Oxymetazoline.
DB01064
The risk or severity of adverse effects can be increased when Phentermine is combined with Isoprenaline.
DB01288
The risk or severity of adverse effects can be increased when Phentermine is combined with Fenoterol.
DB01366
The risk or severity of adverse effects can be increased when Phentermine is combined with Procaterol.
DB01407
The risk or severity of adverse effects can be increased when Phentermine is combined with Clenbuterol.
DB01566
The risk or severity of adverse effects can be increased when Phentermine is combined with Methylenedioxyethamphetamine.
DB06764
The risk or severity of adverse effects can be increased when Phentermine is combined with Tetryzoline.
DB08841
The risk or severity of adverse effects can be increased when Phentermine is combined with Tyramine.
DB08941
The risk or severity of adverse effects can be increased when Phentermine is combined with Isoxsuprine.
DB08985
The risk or severity of adverse effects can be increased when Phentermine is combined with Etilefrine.
DB09203
The risk or severity of adverse effects can be increased when Phentermine is combined with Synephrine.
DB13064
The risk or severity of adverse effects can be increased when Phentermine is combined with Tramazoline.
DB13341
The risk or severity of adverse effects can be increased when Phentermine is combined with Fenozolone.
DB13692
The risk or severity of adverse effects can be increased when Phentermine is combined with Tretoquinol.
DB13777
The risk or severity of adverse effects can be increased when Phentermine is combined with Prenalterol.
DB13852
The risk or severity of adverse effects can be increased when Phentermine is combined with Mefenorex.
DB06152
The risk or severity of adverse effects can be increased when Phentermine is combined with Nylidrin.
DB00206
The serum concentration of Phentermine can be decreased when it is combined with Reserpine.
DB00142
The serum concentration of Phentermine can be decreased when it is combined with Glutamic acid.
DB01170
The serum concentration of Guanethidine can be decreased when it is combined with Phentermine.
DB00311
Ethoxzolamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
DB00703
Methazolamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
DB00909
Zonisamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
DB01144
Diclofenamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
DB00486
The risk or severity of Tachycardia can be increased when Nabilone is combined with Phentermine.
DB05077
The risk or severity of Tachycardia can be increased when SLV319 is combined with Phentermine.
DB06624
The risk or severity of Tachycardia can be increased when Taranabant is combined with Phentermine.
DB11903
The risk or severity of Tachycardia can be increased when GW842166 is combined with Phentermine.
DB12193
The risk or severity of Tachycardia can be increased when Ajulemic acid is combined with Phentermine.
DB12649
The risk or severity of Tachycardia can be increased when Ibipinabant is combined with Phentermine.
DB13070
The risk or severity of Tachycardia can be increased when Surinabant is combined with Phentermine.
DB14043
The risk or severity of Tachycardia can be increased when Palmidrol is combined with Phentermine.
DB14737
The risk or severity of Tachycardia can be increased when Cannabinol is combined with Phentermine.
DB00470
The risk or severity of Tachycardia can be increased when Dronabinol is combined with Phentermine.
DB06155
The risk or severity of Tachycardia can be increased when Rimonabant is combined with Phentermine.
DB14011
The risk or severity of Tachycardia can be increased when Nabiximols is combined with Phentermine.
DB00182
Amphetamine may increase the hypertensive activities of Phentermine.
DB00614
Furazolidone may increase the hypertensive activities of Phentermine.
DB00721
Procaine may increase the hypertensive activities of Phentermine.
DB00752
Tranylcypromine may increase the hypertensive activities of Phentermine.
DB00780
Phenelzine may increase the hypertensive activities of Phentermine.
DB00805
Minaprine may increase the hypertensive activities of Phentermine.
DB01168
Procarbazine may increase the hypertensive activities of Phentermine.
DB01171
Moclobemide may increase the hypertensive activities of Phentermine.
DB01247
Isocarboxazid may increase the hypertensive activities of Phentermine.
DB01367
Rasagiline may increase the hypertensive activities of Phentermine.
DB01626
Pargyline may increase the hypertensive activities of Phentermine.
DB04017
Clorgiline may increase the hypertensive activities of Phentermine.
DB04818
Iproniazid may increase the hypertensive activities of Phentermine.
DB04820
Nialamide may increase the hypertensive activities of Phentermine.
DB06654
Safinamide may increase the hypertensive activities of Phentermine.
DB08550
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypertensive activities of Phentermine.
DB09243
Hydracarbazine may increase the hypertensive activities of Phentermine.
DB09244
Pirlindole may increase the hypertensive activities of Phentermine.
DB09245
Toloxatone may increase the hypertensive activities of Phentermine.
DB09246
Benmoxin may increase the hypertensive activities of Phentermine.
DB09248
Mebanazine may increase the hypertensive activities of Phentermine.
DB09249
Octamoxin may increase the hypertensive activities of Phentermine.
DB09250
Pheniprazine may increase the hypertensive activities of Phentermine.
DB09251
Phenoxypropazine may increase the hypertensive activities of Phentermine.
DB09252
Pivhydrazine may increase the hypertensive activities of Phentermine.
DB09253
Safrazine may increase the hypertensive activities of Phentermine.
DB09254
Caroxazone may increase the hypertensive activities of Phentermine.
DB13875
Harmaline may increase the hypertensive activities of Phentermine.
DB13876
Brofaromine may increase the hypertensive activities of Phentermine.
DB01377
The serum concentration of Phentermine can be increased when it is combined with Magnesium oxide.
DB01390
The serum concentration of Phentermine can be increased when it is combined with Sodium bicarbonate.
DB06723
The serum concentration of Phentermine can be increased when it is combined with Aluminum hydroxide.
DB06724
The serum concentration of Phentermine can be increased when it is combined with Calcium carbonate.
DB08938
The serum concentration of Phentermine can be increased when it is combined with Magaldrate.
DB09104
The serum concentration of Phentermine can be increased when it is combined with Magnesium hydroxide.
DB09281
The serum concentration of Phentermine can be increased when it is combined with Magnesium trisilicate.
DB09481
The serum concentration of Phentermine can be increased when it is combined with Magnesium carbonate.
DB13209
The serum concentration of Phentermine can be increased when it is combined with Bismuth subnitrate.
DB13249
The serum concentration of Phentermine can be increased when it is combined with Magnesium silicate.
DB13280
The serum concentration of Phentermine can be increased when it is combined with Aluminium acetoacetate.
DB13322
The serum concentration of Phentermine can be increased when it is combined with Hydrotalcite.
DB13486
The serum concentration of Phentermine can be increased when it is combined with Magnesium peroxide.
DB13595
The serum concentration of Phentermine can be increased when it is combined with Almasilate.
DB13626
The serum concentration of Phentermine can be increased when it is combined with Aluminium glycinate.
DB13650
The serum concentration of Phentermine can be increased when it is combined with Aloglutamol.
DB13829
The serum concentration of Phentermine can be increased when it is combined with Calcium silicate.
DB14517
The serum concentration of Phentermine can be increased when it is combined with Aluminium phosphate.
DB00307
The metabolism of Phentermine can be increased when combined with Bexarotene.
DB00559
The metabolism of Phentermine can be increased when combined with Bosentan.
DB00607
The metabolism of Phentermine can be increased when combined with Nafcillin.
DB06414
The metabolism of Phentermine can be increased when combined with Etravirine.
DB06442
The metabolism of Phentermine can be increased when combined with Avasimibe.
DB14240
The metabolism of Phentermine can be increased when combined with Echinacea.
DB00312
The metabolism of Phentermine can be increased when combined with Pentobarbital.
DB00648
The metabolism of Phentermine can be increased when combined with Mitotane.
DB01220
The metabolism of Phentermine can be increased when combined with Rifaximin.
DB01234
The metabolism of Phentermine can be increased when combined with Dexamethasone.
DB01323
The metabolism of Phentermine can be increased when combined with St. John's Wort.
DB06595
The metabolism of Phentermine can be increased when combined with Midostaurin.
DB08899
The metabolism of Phentermine can be increased when combined with Enzalutamide.
DB09280
The metabolism of Phentermine can be increased when combined with Lumacaftor.
DB11753
The metabolism of Phentermine can be increased when combined with Rifamycin.
DB11901
The metabolism of Phentermine can be increased when combined with Apalutamide.
DB00564
The metabolism of Carbamazepine can be increased when combined with Phentermine.
DB01045
The metabolism of Rifampicin can be increased when combined with Phentermine.
DB00196
The metabolism of Phentermine can be decreased when combined with Fluconazole.
DB00199
The metabolism of Phentermine can be decreased when combined with Erythromycin.
DB00270
The metabolism of Phentermine can be decreased when combined with Isradipine.
DB00343
The metabolism of Phentermine can be decreased when combined with Diltiazem.
DB01087
The metabolism of Phentermine can be decreased when combined with Primaquine.
DB01110
The metabolism of Phentermine can be decreased when combined with Miconazole.
DB01406
The metabolism of Phentermine can be decreased when combined with Danazol.
DB02703
The metabolism of Phentermine can be decreased when combined with Fusidic acid.
DB06290
The metabolism of Phentermine can be decreased when combined with Simeprevir.
DB06712
The metabolism of Phentermine can be decreased when combined with Nilvadipine.
DB06731
The metabolism of Phentermine can be decreased when combined with Seproxetine.
DB09048
The metabolism of Phentermine can be decreased when combined with Netupitant.
DB09227
The metabolism of Phentermine can be decreased when combined with Barnidipine.
DB09231
The metabolism of Phentermine can be decreased when combined with Benidipine.
DB14019
The metabolism of Phentermine can be decreased when combined with Fosnetupitant.
DB00537
The metabolism of Phentermine can be decreased when combined with Ciprofloxacin.
DB00227
The metabolism of Phentermine can be decreased when combined with Lovastatin.
DB00673
The metabolism of Phentermine can be decreased when combined with Aprepitant.
DB11633
The metabolism of Phentermine can be decreased when combined with Isavuconazole.
DB15982
The metabolism of Phentermine can be decreased when combined with Berotralstat.
DB00763
The metabolism of Methimazole can be decreased when combined with Phentermine.
DB00582
The metabolism of Phentermine can be decreased when combined with Voriconazole.
DB00625
The metabolism of Phentermine can be decreased when combined with Efavirenz.
DB00705
The metabolism of Phentermine can be decreased when combined with Delavirdine.
DB00836
The metabolism of Phentermine can be decreased when combined with Loperamide.
DB00976
The metabolism of Phentermine can be decreased when combined with Telithromycin.
DB01026
The metabolism of Phentermine can be decreased when combined with Ketoconazole.
DB01072
The metabolism of Phentermine can be decreased when combined with Atazanavir.
DB01167
The metabolism of Phentermine can be decreased when combined with Itraconazole.
DB01183
The metabolism of Phentermine can be decreased when combined with Naloxone.
DB01211
The metabolism of Phentermine can be decreased when combined with Clarithromycin.
DB01263
The metabolism of Phentermine can be decreased when combined with Posaconazole.
DB02520
The metabolism of Phentermine can be decreased when combined with Ditiocarb.
DB04868
The metabolism of Phentermine can be decreased when combined with Nilotinib.
DB05521
The metabolism of Phentermine can be decreased when combined with Telaprevir.
DB09065
The metabolism of Phentermine can be decreased when combined with Cobicistat.
DB09101
The metabolism of Phentermine can be decreased when combined with Elvitegravir.
DB09118
The metabolism of Phentermine can be decreased when combined with Stiripentol.
DB11730
The metabolism of Phentermine can be decreased when combined with Ribociclib.
DB11779
The metabolism of Phentermine can be decreased when combined with Danoprevir.
DB13179
The metabolism of Phentermine can be decreased when combined with Troleandomycin.
DB00872
The metabolism of Conivaptan can be decreased when combined with Phentermine.
DB00932
The metabolism of Tipranavir can be decreased when combined with Phentermine.
DB01232
The metabolism of Saquinavir can be decreased when combined with Phentermine.
DB01264
The metabolism of Darunavir can be decreased when combined with Phentermine.
DB01601
The metabolism of Lopinavir can be decreased when combined with Phentermine.
DB08873
The metabolism of Boceprevir can be decreased when combined with Phentermine.
DB06448
The metabolism of Phentermine can be decreased when combined with Lonafarnib.
DB06767
The serum concentration of Phentermine can be decreased when it is combined with Ammonium chloride.
DB14485
The serum concentration of Phentermine can be decreased when it is combined with Zinc ascorbate.
DB14490
The serum concentration of Phentermine can be decreased when it is combined with Ferrous ascorbate.
DB14484
The serum concentration of Phentermine can be decreased when it is combined with Magnesium ascorbate.
DB14486
The serum concentration of Phentermine can be decreased when it is combined with Niacinamide ascorbate.
DB08830
The serum concentration of Phentermine can be decreased when it is combined with Dehydroascorbic acid.
DB14482
The serum concentration of Phentermine can be decreased when it is combined with Sodium ascorbate.
DB14483
The serum concentration of Phentermine can be decreased when it is combined with Calcium ascorbate.
DB14502
The serum concentration of Phentermine can be decreased when it is combined with Sodium phosphate, dibasic.
DB09449
The serum concentration of Phentermine can be decreased when it is combined with Sodium phosphate, monobasic.
DB01037
The risk or severity of adverse effects can be increased when Selegiline is combined with Phentermine.
DB11642
The serum concentration of Phentermine can be decreased when it is combined with Pitolisant.
DB09046
The metabolism of Phentermine can be increased when combined with Metreleptin.
DB00615
The metabolism of Phentermine can be increased when combined with Rifabutin.
DB00949
The metabolism of Phentermine can be increased when combined with Felbamate.
DB01645
The metabolism of Phentermine can be increased when combined with Genistein.
DB04911
The metabolism of Phentermine can be increased when combined with Oritavancin.
DB06201
The metabolism of Phentermine can be increased when combined with Rufinamide.
DB08909
The metabolism of Phentermine can be increased when combined with Glycerol phenylbutyrate.
DB09078
The metabolism of Phentermine can be increased when combined with Lenvatinib.
DB09119
The metabolism of Phentermine can be increased when combined with Eslicarbazepine acetate.
DB11586
The metabolism of Phentermine can be increased when combined with Asunaprevir.
DB11767
The metabolism of Phentermine can be increased when combined with Sarilumab.
DB11560
The metabolism of Phentermine can be increased when combined with Lesinurad.
DB01115
The metabolism of Nifedipine can be increased when combined with Phentermine.
DB00082
The metabolism of Phentermine can be increased when combined with Pegvisomant.
DB00136
The metabolism of Phentermine can be increased when combined with Calcitriol.
DB00180
The metabolism of Phentermine can be increased when combined with Flunisolide.
DB00241
The metabolism of Phentermine can be increased when combined with Butalbital.
DB00301
The metabolism of Phentermine can be increased when combined with Flucloxacillin.
DB00316
The metabolism of Phentermine can be increased when combined with Acetaminophen.
DB00338
The metabolism of Phentermine can be increased when combined with Omeprazole.
DB00357
The metabolism of Phentermine can be increased when combined with Aminoglutethimide.
DB00394
The metabolism of Phentermine can be increased when combined with Beclomethasone dipropionate.
DB00396
The metabolism of Phentermine can be increased when combined with Progesterone.
DB00400
The metabolism of Phentermine can be increased when combined with Griseofulvin.
DB00418
The metabolism of Phentermine can be increased when combined with Secobarbital.
DB00439
The metabolism of Phentermine can be increased when combined with Cerivastatin.
DB00443
The metabolism of Phentermine can be increased when combined with Betamethasone.
DB00448
The metabolism of Phentermine can be increased when combined with Lansoprazole.
DB00474
The metabolism of Phentermine can be increased when combined with Methohexital.
DB00485
The metabolism of Phentermine can be increased when combined with Dicloxacillin.
DB00533
The metabolism of Phentermine can be increased when combined with Rofecoxib.
DB00591
The metabolism of Phentermine can be increased when combined with Fluocinolone acetonide.
DB00599
The metabolism of Phentermine can be increased when combined with Thiopental.
DB00603
The metabolism of Phentermine can be increased when combined with Medroxyprogesterone acetate.
DB00620
The metabolism of Phentermine can be increased when combined with Triamcinolone.
DB00624
The metabolism of Phentermine can be increased when combined with Testosterone.
DB00636
The metabolism of Phentermine can be increased when combined with Clofibrate.
DB00741
The metabolism of Phentermine can be increased when combined with Hydrocortisone.
DB00754
The metabolism of Phentermine can be increased when combined with Ethotoin.
DB00769
The metabolism of Phentermine can be increased when combined with Hydrocortamate.
DB00812
The metabolism of Phentermine can be increased when combined with Phenylbutazone.
DB00857
The metabolism of Phentermine can be increased when combined with Terbinafine.
DB00860
The metabolism of Phentermine can be increased when combined with Prednisolone.
DB00957
The metabolism of Phentermine can be increased when combined with Norgestimate.
DB00959
The metabolism of Phentermine can be increased when combined with Methylprednisolone.
DB01011
The metabolism of Phentermine can be increased when combined with Metyrapone.
DB01030
The metabolism of Phentermine can be increased when combined with Topotecan.
DB01032
The metabolism of Phentermine can be increased when combined with Probenecid.
DB01083
The metabolism of Phentermine can be increased when combined with Orlistat.
DB01138
The metabolism of Phentermine can be increased when combined with Sulfinpyrazone.
DB01154
The metabolism of Phentermine can be increased when combined with Thiamylal.
DB01201
The metabolism of Phentermine can be increased when combined with Rifapentine.
DB01221
The metabolism of Phentermine can be increased when combined with Ketamine.
DB01285
The metabolism of Phentermine can be increased when combined with Corticotropin.
DB01333
The metabolism of Phentermine can be increased when combined with Cefradine.
DB01351
The metabolism of Phentermine can be increased when combined with Amobarbital.
DB01352
The metabolism of Phentermine can be increased when combined with Aprobarbital.
DB01380
The metabolism of Phentermine can be increased when combined with Cortisone acetate.
DB01384
The metabolism of Phentermine can be increased when combined with Paramethasone.
DB01483
The metabolism of Phentermine can be increased when combined with Barbital.
DB01609
The metabolism of Phentermine can be increased when combined with Deferasirox.
DB04817
The metabolism of Phentermine can be increased when combined with Metamizole.
DB04905
The metabolism of Phentermine can be increased when combined with Tesmilifene.
DB04920
The metabolism of Phentermine can be increased when combined with Clevidipine.
DB06636
The metabolism of Phentermine can be increased when combined with Isavuconazonium.
DB06708
The metabolism of Phentermine can be increased when combined with Lumefantrine.
DB06739
The metabolism of Phentermine can be increased when combined with Seratrodast.
DB08883
The metabolism of Phentermine can be increased when combined with Perampanel.
DB08905
The metabolism of Phentermine can be increased when combined with Formestane.
DB08906
The metabolism of Phentermine can be increased when combined with Fluticasone furoate.
DB08911
The metabolism of Phentermine can be increased when combined with Trametinib.
DB08970
The metabolism of Phentermine can be increased when combined with Fluprednidene.
DB09001
The metabolism of Phentermine can be increased when combined with Barbexaclone.
DB09383
The metabolism of Phentermine can be increased when combined with Meprednisone.
DB11487
The metabolism of Phentermine can be increased when combined with Dexamethasone isonicotinate.
DB11921
The metabolism of Phentermine can be increased when combined with Deflazacort.
DB13003
The metabolism of Phentermine can be increased when combined with Cortivazol.
DB13208
The metabolism of Phentermine can be increased when combined with Prednylidene.
DB13843
The metabolism of Phentermine can be increased when combined with Cloprednol.
DB13867
The metabolism of Phentermine can be increased when combined with Fluticasone.
DB13943
The metabolism of Phentermine can be increased when combined with Testosterone cypionate.
DB13944
The metabolism of Phentermine can be increased when combined with Testosterone enanthate.
DB13952
The metabolism of Phentermine can be increased when combined with Estradiol acetate.
DB13953
The metabolism of Phentermine can be increased when combined with Estradiol benzoate.
DB13954
The metabolism of Phentermine can be increased when combined with Estradiol cypionate.
DB13955
The metabolism of Phentermine can be increased when combined with Estradiol dienanthate.
DB13956
The metabolism of Phentermine can be increased when combined with Estradiol valerate.
DB14512
The metabolism of Phentermine can be increased when combined with Mometasone furoate.
DB14539
The metabolism of Phentermine can be increased when combined with Hydrocortisone acetate.
DB14545
The metabolism of Phentermine can be increased when combined with Hydrocortisone succinate.
DB14631
The metabolism of Phentermine can be increased when combined with Prednisolone phosphate.
DB14633
The metabolism of Phentermine can be increased when combined with Prednisolone hemisuccinate.
DB14644
The metabolism of Phentermine can be increased when combined with Methylprednisolone hemisuccinate.
DB14646
The metabolism of Phentermine can be increased when combined with Prednisone acetate.
DB14652
The metabolism of Phentermine can be increased when combined with Clocortolone acetate.
DB14659
The metabolism of Phentermine can be increased when combined with Melengestrol acetate.
DB14669
The metabolism of Phentermine can be increased when combined with Betamethasone phosphate.
DB14681
The metabolism of Phentermine can be increased when combined with Cortisone.
DB00602
The metabolism of Phentermine can be increased when combined with Ivermectin.
DB00349
The metabolism of Clobazam can be increased when combined with Phentermine.
DB00163
The metabolism of Phentermine can be increased when combined with Vitamin E.
DB00776
The metabolism of Phentermine can be increased when combined with Oxcarbazepine.
DB14575
The metabolism of Phentermine can be increased when combined with Eslicarbazepine.
DB01222
The metabolism of Phentermine can be increased when combined with Budesonide.
DB01394
The metabolism of Phentermine can be increased when combined with Colchicine.
DB06717
The metabolism of Phentermine can be increased when combined with Fosaprepitant.
DB01013
The metabolism of Phentermine can be increased when combined with Clobetasol propionate.
DB01047
The metabolism of Phentermine can be increased when combined with Fluocinonide.
DB14540
The metabolism of Phentermine can be increased when combined with Hydrocortisone butyrate.
DB00764
The metabolism of Phentermine can be increased when combined with Mometasone.
DB15822
The metabolism of Phentermine can be increased when combined with Pralsetinib.
DB08971
The metabolism of Phentermine can be increased when combined with Fluocortolone.
DB11750
The metabolism of Phentermine can be increased when combined with Clobetasol.
DB15566
The metabolism of Phentermine can be increased when combined with Prednisolone acetate.
DB09095
The metabolism of Phentermine can be increased when combined with Difluocortolone.
DB09238
The metabolism of Manidipine can be decreased when combined with Phentermine.
DB01369
The metabolism of Phentermine can be decreased when combined with Quinupristin.
DB01764
The metabolism of Phentermine can be decreased when combined with Dalfopristin.
DB04894
The metabolism of Phentermine can be decreased when combined with Vapreotide.
DB05928
The metabolism of Phentermine can be decreased when combined with Dovitinib.
DB06663
The metabolism of Phentermine can be decreased when combined with Pasireotide.
DB06791
The metabolism of Phentermine can be decreased when combined with Lanreotide.
DB09099
The metabolism of Phentermine can be decreased when combined with Somatostatin.
DB00243
The metabolism of Ranolazine can be decreased when combined with Phentermine.
DB00778
The metabolism of Roxithromycin can be decreased when combined with Phentermine.
DB01259
The metabolism of Lapatinib can be decreased when combined with Phentermine.
DB04839
The metabolism of Cyproterone acetate can be decreased when combined with Phentermine.
DB08820
The metabolism of Ivacaftor can be decreased when combined with Phentermine.
DB12332
The metabolism of Rucaparib can be decreased when combined with Phentermine.
DB13941
The metabolism of Piperaquine can be decreased when combined with Phentermine.
DB13879
The metabolism of Phentermine can be decreased when combined with Glecaprevir.
DB11837
The metabolism of Phentermine can be decreased when combined with Osilodrostat.
DB08864
The metabolism of Phentermine can be decreased when combined with Rilpivirine.
DB04794
The metabolism of Phentermine can be decreased when combined with Bifonazole.
DB14009
The metabolism of Medical Cannabis can be decreased when combined with Phentermine.
DB00041
The metabolism of Phentermine can be decreased when combined with Aldesleukin.
DB00254
The metabolism of Phentermine can be decreased when combined with Doxycycline.
DB00255
The metabolism of Phentermine can be decreased when combined with Diethylstilbestrol.
DB00317
The metabolism of Phentermine can be decreased when combined with Gefitinib.
DB00353
The metabolism of Phentermine can be decreased when combined with Methylergometrine.
DB00358
The metabolism of Phentermine can be decreased when combined with Mefloquine.
DB00435
The metabolism of Phentermine can be decreased when combined with Nitric Oxide.
DB00446
The metabolism of Phentermine can be decreased when combined with Chloramphenicol.
DB00481
The metabolism of Phentermine can be decreased when combined with Raloxifene.
DB00549
The metabolism of Phentermine can be decreased when combined with Zafirlukast.
DB00588
The metabolism of Phentermine can be decreased when combined with Fluticasone propionate.
DB00627
The metabolism of Phentermine can be decreased when combined with Niacin.
DB00678
The metabolism of Phentermine can be decreased when combined with Losartan.
DB00681
The metabolism of Phentermine can be decreased when combined with Amphotericin B.
DB00759
The metabolism of Phentermine can be decreased when combined with Tetracycline.
DB00829
The metabolism of Phentermine can be decreased when combined with Diazepam.
DB00845
The metabolism of Phentermine can be decreased when combined with Clofazimine.
DB00916
The metabolism of Phentermine can be decreased when combined with Metronidazole.
DB00954
The metabolism of Phentermine can be decreased when combined with Dirithromycin.
DB01029
The metabolism of Phentermine can be decreased when combined with Irbesartan.
DB01059
The metabolism of Phentermine can be decreased when combined with Norfloxacin.
DB01062
The metabolism of Phentermine can be decreased when combined with Oxybutynin.
DB01085
The metabolism of Phentermine can be decreased when combined with Pilocarpine.
DB01129
The metabolism of Phentermine can be decreased when combined with Rabeprazole.
DB01152
The metabolism of Phentermine can be decreased when combined with Candicidin.
DB01204
The metabolism of Phentermine can be decreased when combined with Mitoxantrone.
DB01275
The metabolism of Phentermine can be decreased when combined with Hydralazine.
DB01388
The metabolism of Phentermine can be decreased when combined with Mibefradil.
DB01587
The metabolism of Phentermine can be decreased when combined with Ketazolam.
DB01628
The metabolism of Phentermine can be decreased when combined with Etoricoxib.
DB01685
The metabolism of Phentermine can be decreased when combined with Topiroxostat.
DB01698
The metabolism of Phentermine can be decreased when combined with Rutin.
DB01873
The metabolism of Phentermine can be decreased when combined with Epothilone D.
DB02709
The metabolism of Phentermine can be decreased when combined with Resveratrol.
DB03010
The metabolism of Phentermine can be decreased when combined with Patupilone.
DB04070
The metabolism of Phentermine can be decreased when combined with 6-Deoxyerythronolide B.
DB05482
The metabolism of Phentermine can be decreased when combined with 7-ethyl-10-hydroxycamptothecin.
DB05814
The metabolism of Phentermine can be decreased when combined with GPI-1485.
DB05903
The metabolism of Phentermine can be decreased when combined with KOS-1584.
DB06174
The metabolism of Phentermine can be decreased when combined with Noscapine.
DB06233
The metabolism of Phentermine can be decreased when combined with Ridaforolimus.
DB06268
The metabolism of Phentermine can be decreased when combined with Sitaxentan.
DB06318
The metabolism of Phentermine can be decreased when combined with AVE9633.
DB06342
The metabolism of Phentermine can be decreased when combined with Coltuximab ravtansine.
DB06370
The metabolism of Phentermine can be decreased when combined with Indisulam.
DB06412
The metabolism of Phentermine can be decreased when combined with Oxymetholone.
DB06419
The metabolism of Phentermine can be decreased when combined with Cethromycin.
DB06458
The metabolism of Phentermine can be decreased when combined with Remacemide.
DB06469
The metabolism of Phentermine can be decreased when combined with Lestaurtinib.
DB06587
The metabolism of Phentermine can be decreased when combined with Mitemcinal.
DB06774
The metabolism of Phentermine can be decreased when combined with Capsaicin.
DB07348
The metabolism of Phentermine can be decreased when combined with Brefeldin A.
DB08811
The metabolism of Phentermine can be decreased when combined with Tofisopam.
DB09235
The metabolism of Phentermine can be decreased when combined with Efonidipine.
DB09308
The metabolism of Phentermine can be decreased when combined with Solithromycin.
DB09309
The metabolism of Phentermine can be decreased when combined with Kitasamycin.
DB11198
The metabolism of Phentermine can be decreased when combined with Peppermint oil.
DB11383
The metabolism of Phentermine can be decreased when combined with Carbomycin.
DB11400
The metabolism of Phentermine can be decreased when combined with Doramectin.
DB11405
The metabolism of Phentermine can be decreased when combined with Eprinomectin.
DB11442
The metabolism of Phentermine can be decreased when combined with Oleandomycin.
DB11459
The metabolism of Phentermine can be decreased when combined with Selamectin.
DB11470
The metabolism of Phentermine can be decreased when combined with Tildipirosin.
DB11471
The metabolism of Phentermine can be decreased when combined with Tilmicosin.
DB11475
The metabolism of Phentermine can be decreased when combined with Tylosin.
DB11554
The metabolism of Phentermine can be decreased when combined with Tylvalosin.
DB11574
The metabolism of Phentermine can be decreased when combined with Elbasvir.
DB11752
The metabolism of Phentermine can be decreased when combined with Bryostatin 1.
DB11805
The metabolism of Phentermine can be decreased when combined with Saracatinib.
DB12010
The metabolism of Phentermine can be decreased when combined with Fostamatinib.
DB12070
The metabolism of Phentermine can be decreased when combined with Letermovir.
DB12089
The metabolism of Phentermine can be decreased when combined with Lorvotuzumab mertansine.
DB12245
The metabolism of Phentermine can be decreased when combined with Triclabendazole.
DB12266
The metabolism of Phentermine can be decreased when combined with Epofolate.
DB12391
The metabolism of Phentermine can be decreased when combined with Sagopilone.
DB12489
The metabolism of Phentermine can be decreased when combined with Mirvetuximab Soravtansine.
DB12532
The metabolism of Phentermine can be decreased when combined with Oxetacaine.
DB13287
The metabolism of Phentermine can be decreased when combined with Miocamycin.
DB13338
The metabolism of Phentermine can be decreased when combined with Flurithromycin.
DB13409
The metabolism of Phentermine can be decreased when combined with Rokitamycin.
DB13456
The metabolism of Phentermine can be decreased when combined with Midecamycin.
DB13950
The metabolism of Phentermine can be decreased when combined with WIN 55212-2.
DB13975
The metabolism of Phentermine can be decreased when combined with Black cohosh.
DB01095
The metabolism of Phentermine can be decreased when combined with Fluvastatin.
DB01093
The metabolism of Phentermine can be decreased when combined with Dimethyl sulfoxide.
DB00701
The metabolism of Phentermine can be decreased when combined with Amprenavir.
DB14635
The metabolism of Phentermine can be decreased when combined with Curcumin sulfate.
DB01023
The metabolism of Felodipine can be decreased when combined with Phentermine.
DB00683
The metabolism of Phentermine can be decreased when combined with Midazolam.
DB08816
The metabolism of Phentermine can be decreased when combined with Ticagrelor.
DB00104
The metabolism of Phentermine can be decreased when combined with Octreotide.
DB00694
The metabolism of Phentermine can be decreased when combined with Daunorubicin.
DB13633
The metabolism of Phentermine can be decreased when combined with Mepartricin.
DB00619
The metabolism of Phentermine can be decreased when combined with Imatinib.
DB00248
The metabolism of Cabergoline can be decreased when combined with Phentermine.
DB08912
The metabolism of Phentermine can be decreased when combined with Dabrafenib.
DB08865
The metabolism of Phentermine can be decreased when combined with Crizotinib.
DB11581
The metabolism of Phentermine can be decreased when combined with Venetoclax.
DB12015
The metabolism of Phentermine can be decreased when combined with Alpelisib.
DB00531
The metabolism of Phentermine can be decreased when combined with Cyclophosphamide.
DB00570
The metabolism of Phentermine can be decreased when combined with Vinblastine.
DB00675
The metabolism of Phentermine can be decreased when combined with Tamoxifen.
DB00773
The metabolism of Phentermine can be decreased when combined with Etoposide.
DB01181
The metabolism of Phentermine can be decreased when combined with Ifosfamide.
DB08881
The metabolism of Phentermine can be decreased when combined with Vemurafenib.
DB09330
The metabolism of Phentermine can be decreased when combined with Osimertinib.
DB12267
The metabolism of Phentermine can be decreased when combined with Brigatinib.
DB13874
The metabolism of Phentermine can be decreased when combined with Enasidenib.
DB14568
The metabolism of Phentermine can be decreased when combined with Ivosidenib.
DB11703
The metabolism of Phentermine can be decreased when combined with Acalabrutinib.
DB00398
The metabolism of Phentermine can be decreased when combined with Sorafenib.
DB00444
The metabolism of Phentermine can be decreased when combined with Teniposide.
DB00530
The metabolism of Phentermine can be decreased when combined with Erlotinib.
DB00997
The metabolism of Phentermine can be decreased when combined with Doxorubicin.
DB01248
The metabolism of Phentermine can be decreased when combined with Docetaxel.
DB05773
The metabolism of Phentermine can be decreased when combined with Trastuzumab emtansine.
DB06616
The metabolism of Phentermine can be decreased when combined with Bosutinib.
DB08870
The metabolism of Phentermine can be decreased when combined with Brentuximab vedotin.
DB08896
The metabolism of Phentermine can be decreased when combined with Regorafenib.
DB00091
The metabolism of Cyclosporine can be decreased when combined with Phentermine.
DB00204
The metabolism of Dofetilide can be decreased when combined with Phentermine.
DB00277
The metabolism of Theophylline can be decreased when combined with Phentermine.
DB00682
The metabolism of Warfarin can be decreased when combined with Phentermine.
DB00864
The metabolism of Tacrolimus can be decreased when combined with Phentermine.
DB00877
The metabolism of Sirolimus can be decreased when combined with Phentermine.
DB00946
The metabolism of Phenprocoumon can be decreased when combined with Phentermine.
DB01008
The metabolism of Busulfan can be decreased when combined with Phentermine.
DB01118
The metabolism of Amiodarone can be decreased when combined with Phentermine.
DB01223
The metabolism of Aminophylline can be decreased when combined with Phentermine.
DB01229
The metabolism of Paclitaxel can be decreased when combined with Phentermine.
DB01254
The metabolism of Dasatinib can be decreased when combined with Phentermine.
DB01396
The metabolism of Digitoxin can be decreased when combined with Phentermine.
DB01418
The metabolism of Acenocoumarol can be decreased when combined with Phentermine.
DB01590
The metabolism of Everolimus can be decreased when combined with Phentermine.
DB06287
The metabolism of Temsirolimus can be decreased when combined with Phentermine.
DB01128
The metabolism of Bicalutamide can be decreased when combined with Phentermine.
DB05239
The metabolism of Cobimetinib can be decreased when combined with Phentermine.
DB06589
The metabolism of Pazopanib can be decreased when combined with Phentermine.
DB09063
The metabolism of Ceritinib can be decreased when combined with Phentermine.
DB09073
The metabolism of Palbociclib can be decreased when combined with Phentermine.
DB09074
The metabolism of Olaparib can be decreased when combined with Phentermine.
DB11963
The metabolism of Dacomitinib can be decreased when combined with Phentermine.
DB12371
The metabolism of Siponimod can be decreased when combined with Phentermine.
DB00575
The metabolism of Clonidine can be decreased when combined with Phentermine.
DB01227
The metabolism of Levacetylmethadol can be decreased when combined with Phentermine.
DB08827
The metabolism of Phentermine can be decreased when combined with Lomitapide.
DB00563
The metabolism of Methotrexate can be decreased when combined with Phentermine.
DB00361
The metabolism of Vinorelbine can be decreased when combined with Phentermine.
DB00541
The metabolism of Vincristine can be decreased when combined with Phentermine.
DB04572
The metabolism of Thiotepa can be decreased when combined with Phentermine.
DB05109
The metabolism of Trabectedin can be decreased when combined with Phentermine.
DB05294
The metabolism of Vandetanib can be decreased when combined with Phentermine.
DB11363
The metabolism of Alectinib can be decreased when combined with Phentermine.
DB11641
The metabolism of Vinflunine can be decreased when combined with Phentermine.
DB15035
The metabolism of Zanubrutinib can be decreased when combined with Phentermine.
DB00188
The metabolism of Bortezomib can be decreased when combined with Phentermine.
DB00309
The metabolism of Vindesine can be decreased when combined with Phentermine.
DB04845
The metabolism of Ixabepilone can be decreased when combined with Phentermine.
DB06603
The metabolism of Panobinostat can be decreased when combined with Phentermine.
DB06626
The metabolism of Axitinib can be decreased when combined with Phentermine.
DB08877
The metabolism of Ruxolitinib can be decreased when combined with Phentermine.
DB08901
The metabolism of Ponatinib can be decreased when combined with Phentermine.
DB09054
The metabolism of Idelalisib can be decreased when combined with Phentermine.
DB09143
The metabolism of Sonidegib can be decreased when combined with Phentermine.
DB09570
The metabolism of Ixazomib can be decreased when combined with Phentermine.
DB11828
The metabolism of Neratinib can be decreased when combined with Phentermine.
DB11986
The metabolism of Entrectinib can be decreased when combined with Phentermine.
DB12147
The metabolism of Erdafitinib can be decreased when combined with Phentermine.
DB12483
The metabolism of Copanlisib can be decreased when combined with Phentermine.
DB12978
The metabolism of Pexidartinib can be decreased when combined with Phentermine.
DB00762
The metabolism of Irinotecan can be decreased when combined with Phentermine.
DB06176
The metabolism of Romidepsin can be decreased when combined with Phentermine.
DB06212
The metabolism of Tolvaptan can be decreased when combined with Phentermine.
DB08910
The metabolism of Pomalidomide can be decreased when combined with Phentermine.
DB11817
The metabolism of Baricitinib can be decreased when combined with Phentermine.
DB12001
The metabolism of Abemaciclib can be decreased when combined with Phentermine.
DB06772
The metabolism of Cabazitaxel can be decreased when combined with Phentermine.
DB11273
The metabolism of Dihydroergocornine can be decreased when combined with Phentermine.
DB13385
The metabolism of Dihydroergocryptine can be decreased when combined with Phentermine.
DB01098
The metabolism of Rosuvastatin can be decreased when combined with Phentermine.
DB00186
The metabolism of Phentermine can be decreased when combined with Lorazepam.
DB00207
The metabolism of Azithromycin can be decreased when combined with Phentermine.
DB00208
The metabolism of Ticlopidine can be decreased when combined with Phentermine.
DB00426
The metabolism of Famciclovir can be decreased when combined with Phentermine.
DB00518
The metabolism of Albendazole can be decreased when combined with Phentermine.
DB00567
The metabolism of Cephalexin can be decreased when combined with Phentermine.
DB00717
The metabolism of Norethisterone can be decreased when combined with Phentermine.
DB01039
The metabolism of Fenofibrate can be decreased when combined with Phentermine.
DB01411
The metabolism of Pranlukast can be decreased when combined with Phentermine.
DB01431
The metabolism of Allylestrenol can be decreased when combined with Phentermine.
DB01656
The metabolism of Roflumilast can be decreased when combined with Phentermine.
DB06218
The metabolism of Lacosamide can be decreased when combined with Phentermine.
DB06480
The metabolism of Prucalopride can be decreased when combined with Phentermine.
DB09030
The metabolism of Vorapaxar can be decreased when combined with Phentermine.
DB09034
The metabolism of Suvorexant can be decreased when combined with Phentermine.
DB09071
The metabolism of Tasimelteon can be decreased when combined with Phentermine.
DB09079
The metabolism of Nintedanib can be decreased when combined with Phentermine.
DB09299
The metabolism of Tenofovir alafenamide can be decreased when combined with Phentermine.
DB11094
The metabolism of Vitamin D can be decreased when combined with Phentermine.
DB11952
The metabolism of Duvelisib can be decreased when combined with Phentermine.
DB12141
The metabolism of Gilteritinib can be decreased when combined with Phentermine.
DB12515
The metabolism of 9-aminocamptothecin can be decreased when combined with Phentermine.
DB12952
The metabolism of Methylprednisone can be decreased when combined with Phentermine.
DB14126
The metabolism of Tenofovir can be decreased when combined with Phentermine.
DB01395
The metabolism of Drospirenone can be decreased when combined with Phentermine.
DB15444
The metabolism of Elexacaftor can be decreased when combined with Phentermine.
DB12825
The metabolism of Lefamulin can be decreased when combined with Phentermine.
DB12887
The metabolism of Tazemetostat can be decreased when combined with Phentermine.
DB00247
The metabolism of Methysergide can be decreased when combined with Phentermine.
DB00604
The metabolism of Cisapride can be decreased when combined with Phentermine.
DB04272
The excretion of Phentermine can be decreased when combined with Citric acid.
DB09125
The excretion of Phentermine can be decreased when combined with Potassium citrate.
DB09154
The excretion of Phentermine can be decreased when combined with Sodium citrate.
DB09459
The excretion of Phentermine can be decreased when combined with L-tartaric acid.
DB00315
The metabolism of Zolmitriptan can be decreased when combined with Phentermine.
DB00388
The metabolism of Phenylephrine can be decreased when combined with Phentermine.
DB00669
The metabolism of Sumatriptan can be decreased when combined with Phentermine.
DB00918
The metabolism of Almotriptan can be decreased when combined with Phentermine.
DB00952
The metabolism of Naratriptan can be decreased when combined with Phentermine.
DB00953
The metabolism of Rizatriptan can be decreased when combined with Phentermine.
DB00988
The metabolism of Dopamine can be decreased when combined with Phentermine.
DB12329
The metabolism of Eravacycline can be decreased when combined with Phentermine.
DB01445
The metabolism of Bufotenine can be decreased when combined with Phentermine.
DB04889
The metabolism of Bicifadine can be decreased when combined with Phentermine.
DB00150
The risk or severity of serotonin syndrome can be increased when Tryptophan is combined with Phentermine.
DB00176
The risk or severity of serotonin syndrome can be increased when Fluvoxamine is combined with Phentermine.
DB00215
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Citalopram.
DB00285
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Venlafaxine.
DB00313
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Valproic acid.
DB00377
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Palonosetron.
DB00408
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Loxapine.
DB00476
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Duloxetine.
DB00514
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dextromethorphan.
DB00579
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Mazindol.
DB00589
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Lisuride.
DB00660
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Metaxalone.
DB00714
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Apomorphine.
DB00715
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Paroxetine.
DB00757
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dolasetron.
DB00852
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Pseudoephedrine.
DB00865
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Benzphetamine.
DB00889
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Granisetron.
DB00904
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Ondansetron.
DB00907
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Cocaine.
DB00915
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Amantadine.
DB00937
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Diethylpropion.
DB00951
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Isoniazid.
DB00998
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Frovatriptan.
DB01079
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Tegaserod.
DB01105
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Sibutramine.
DB01186
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Pergolide.
DB01191
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dexfenfluramine.
DB01233
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Metoclopramide.
DB01235
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Levodopa.
DB01253
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Ergometrine.
DB01255
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Lisdexamfetamine.
DB01365
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Mephentermine.
DB01442
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with MMDA.
DB01454
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Midomafetamine.
DB01467
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with 2,5-Dimethoxy-4-ethylamphetamine.
DB01484
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
DB01488
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dimethyltryptamine.
DB01509
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Tenamfetamine.
DB01556
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Chlorphentermine.
DB01576
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dextroamphetamine.
DB01577
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Metamfetamine.
DB04829
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Lysergic acid diethylamide.
DB04832
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Zimelidine.
DB04842
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Fluspirilene.
DB04871
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Lorcaserin.
DB04884
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dapoxetine.
DB04896
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Milnacipran.
DB04908
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Flibanserin.
DB04948
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Lofexidine.
DB05271
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Rotigotine.
DB05316
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Pimavanserin.
DB06109
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with YKP-1358.
DB06144
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Sertindole.
DB06684
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Vilazodone.
DB06700
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Desvenlafaxine.
DB06701
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Dexmethylphenidate.
DB08167
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Methylthioninium.
DB08810
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Cinitapride.
DB08839
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Serotonin.
DB08918
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Levomilnacipran.
DB08953
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Indalpine.
DB09061
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Cannabidiol.
DB09068
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Vortioxetine.
DB09194
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Etoperidone.
DB09223
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Blonanserin.
DB09225
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Zotepine.
DB09286
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Pipamperone.
DB09480
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Iofetamine I-123.
DB11675
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Mosapride.
DB12071
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Vabicaserin.
DB12080
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Ritobegron.
DB12110
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with m-Chlorophenylpiperazine.
DB12111
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with MK-212.
DB12184
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Gepirone.
DB12465
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Ketanserin.
DB12725
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with TD-8954.
DB12833
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Tandospirone.
DB12883
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Eltoprazine.
DB13108
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Mephedrone.
DB13233
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Alaproclate.
DB13550
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Bifemelane.
DB13624
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Methoxyphenamine.
DB13703
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Gepefrine.
DB13910
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Valproate bismuth.
DB13940
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
DB13948
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine.
DB14010
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with 5-methoxy-N,N-dimethyltryptamine.
DB01104
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Sertraline.
DB00490
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Buspirone.
DB00216
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Eletriptan.
DB00924
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Cyclobenzaprine.
DB00822
The therapeutic efficacy of Phentermine can be decreased when used in combination with Disulfiram.
DB01364
The therapeutic efficacy of Ephedrine can be increased when used in combination with Phentermine.
DB00368
The therapeutic efficacy of Phentermine can be increased when used in combination with Norepinephrine.
DB00668
The therapeutic efficacy of Phentermine can be increased when used in combination with Epinephrine.
DB06262
The therapeutic efficacy of Phentermine can be increased when used in combination with Droxidopa.
DB06707
The therapeutic efficacy of Phentermine can be increased when used in combination with Levonordefrin.
DB06814
The therapeutic efficacy of Phentermine can be increased when used in combination with Protokylol.
DB11124
The therapeutic efficacy of Phentermine can be increased when used in combination with Racepinephrine.
DB12927
The therapeutic efficacy of Phentermine can be increased when used in combination with Theodrenaline.
DB13917
The therapeutic efficacy of Phentermine can be increased when used in combination with Deoxyepinephrine.
DB00005
The metabolism of Phentermine can be increased when combined with Etanercept.
DB00026
The metabolism of Phentermine can be increased when combined with Anakinra.
DB00051
The metabolism of Phentermine can be increased when combined with Adalimumab.
DB00065
The metabolism of Phentermine can be increased when combined with Infliximab.
DB01281
The metabolism of Phentermine can be increased when combined with Abatacept.
DB04956
The metabolism of Phentermine can be increased when combined with Afelimomab.
DB05676
The metabolism of Phentermine can be increased when combined with Apremilast.
DB06168
The metabolism of Phentermine can be increased when combined with Canakinumab.
DB06273
The metabolism of Phentermine can be increased when combined with Tocilizumab.
DB06372
The metabolism of Phentermine can be increased when combined with Rilonacept.
DB06674
The metabolism of Phentermine can be increased when combined with Golimumab.
DB08904
The metabolism of Phentermine can be increased when combined with Certolizumab pegol.
DB09029
The metabolism of Phentermine can be increased when combined with Secukinumab.
DB09036
The metabolism of Phentermine can be increased when combined with Siltuximab.
DB14724
The metabolism of Phentermine can be increased when combined with Emapalumab.
DB00209
The risk or severity of Tachycardia can be increased when Phentermine is combined with Trospium.
DB00219
The risk or severity of Tachycardia can be increased when Phentermine is combined with Oxyphenonium.
DB00261
The risk or severity of Tachycardia can be increased when Phentermine is combined with Anagrelide.
DB00332
The risk or severity of Tachycardia can be increased when Phentermine is combined with Ipratropium.
DB00340
The risk or severity of Tachycardia can be increased when Phentermine is combined with Metixene.
DB00376
The risk or severity of Tachycardia can be increased when Phentermine is combined with Trihexyphenidyl.
DB00383
The risk or severity of Tachycardia can be increased when Phentermine is combined with Oxyphencyclimine.
DB00387
The risk or severity of Tachycardia can be increased when Phentermine is combined with Procyclidine.
DB00424
The risk or severity of Tachycardia can be increased when Phentermine is combined with Hyoscyamine.
DB00462
The risk or severity of Tachycardia can be increased when Phentermine is combined with Methscopolamine bromide.
DB00483
The risk or severity of Tachycardia can be increased when Phentermine is combined with Gallamine triethiodide.
DB00505
The risk or severity of Tachycardia can be increased when Phentermine is combined with Tridihexethyl.
DB00517
The risk or severity of Tachycardia can be increased when Phentermine is combined with Anisotropine methylbromide.
DB00640
The risk or severity of Tachycardia can be increased when Phentermine is combined with Adenosine.
DB00670
The risk or severity of Tachycardia can be increased when Phentermine is combined with Pirenzepine.
DB00697
The risk or severity of Tachycardia can be increased when Phentermine is combined with Tizanidine.
DB00725
The risk or severity of Tachycardia can be increased when Phentermine is combined with Homatropine methylbromide.
DB00728
The risk or severity of Tachycardia can be increased when Phentermine is combined with Rocuronium.
DB00747
The risk or severity of Tachycardia can be increased when Phentermine is combined with Scopolamine.
DB00771
The risk or severity of Tachycardia can be increased when Phentermine is combined with Clidinium.
DB00782
The risk or severity of Tachycardia can be increased when Phentermine is combined with Propantheline.
DB00804
The risk or severity of Tachycardia can be increased when Phentermine is combined with Dicyclomine.
DB00810
The risk or severity of Tachycardia can be increased when Phentermine is combined with Biperiden.
DB00942
The risk or severity of Tachycardia can be increased when Phentermine is combined with Cycrimine.
DB00986
The risk or severity of Tachycardia can be increased when Phentermine is combined with Glycopyrronium.
DB01148
The risk or severity of Tachycardia can be increased when Phentermine is combined with Flavoxate.
DB01226
The risk or severity of Tachycardia can be increased when Phentermine is combined with Mivacurium.
DB01231
The risk or severity of Tachycardia can be increased when Phentermine is combined with Diphenidol.
DB01336
The risk or severity of Tachycardia can be increased when Phentermine is combined with Metocurine.
DB01337
The risk or severity of Tachycardia can be increased when Phentermine is combined with Pancuronium.
DB01338
The risk or severity of Tachycardia can be increased when Phentermine is combined with Pipecuronium.
DB01625
The risk or severity of Tachycardia can be increased when Phentermine is combined with Isopropamide.
DB04834
The risk or severity of Tachycardia can be increased when Phentermine is combined with Rapacuronium.
DB04843
The risk or severity of Tachycardia can be increased when Phentermine is combined with Mepenzolate.
DB06787
The risk or severity of Tachycardia can be increased when Phentermine is combined with Hexocyclium.
DB08897
The risk or severity of Tachycardia can be increased when Phentermine is combined with Aclidinium.
DB08997
The risk or severity of Tachycardia can be increased when Phentermine is combined with Dexetimide.
DB09023
The risk or severity of Tachycardia can be increased when Phentermine is combined with Benactyzine.
DB09076
The risk or severity of Tachycardia can be increased when Phentermine is combined with Umeclidinium.
DB09300
The risk or severity of Tachycardia can be increased when Phentermine is combined with Butylscopolamine.
DB11315
The risk or severity of Tachycardia can be increased when Phentermine is combined with Methscopolamine.
DB12086
The risk or severity of Tachycardia can be increased when Phentermine is combined with Oxitropium.
DB12554
The risk or severity of Tachycardia can be increased when Phentermine is combined with Mebeverine.
DB13252
The risk or severity of Tachycardia can be increased when Phentermine is combined with Tropatepine.
DB13254
The risk or severity of Tachycardia can be increased when Phentermine is combined with Prifinium.
DB13351
The risk or severity of Tachycardia can be increased when Phentermine is combined with Piperidolate.
DB13369
The risk or severity of Tachycardia can be increased when Phentermine is combined with Benzilone.
DB13380
The risk or severity of Tachycardia can be increased when Phentermine is combined with Difemerine.
DB13413
The risk or severity of Tachycardia can be increased when Phentermine is combined with Phenglutarimide.
DB13448
The risk or severity of Tachycardia can be increased when Phentermine is combined with Mazaticol.
DB13468
The risk or severity of Tachycardia can be increased when Phentermine is combined with Etybenzatropine.
DB13505
The risk or severity of Tachycardia can be increased when Phentermine is combined with Emepronium.
DB13507
The risk or severity of Tachycardia can be increased when Phentermine is combined with Poldine.
DB13542
The risk or severity of Tachycardia can be increased when Phentermine is combined with Bevonium.
DB13581
The risk or severity of Tachycardia can be increased when Phentermine is combined with Rociverine.
DB13619
The risk or severity of Tachycardia can be increased when Phentermine is combined with Bornaprine.
DB13636
The risk or severity of Tachycardia can be increased when Phentermine is combined with Etanautine.
DB13666
The risk or severity of Tachycardia can be increased when Phentermine is combined with Tiemonium iodide.
DB13678
The risk or severity of Tachycardia can be increased when Phentermine is combined with Dihexyverine.
DB13695
The risk or severity of Tachycardia can be increased when Phentermine is combined with Penthienate.
DB13720
The risk or severity of Tachycardia can be increased when Phentermine is combined with Diphemanil.
DB13738
The risk or severity of Tachycardia can be increased when Phentermine is combined with Camylofin.
DB13759
The risk or severity of Tachycardia can be increased when Phentermine is combined with Fenpiverinium.
DB13769
The risk or severity of Tachycardia can be increased when Phentermine is combined with Emetonium iodide.
DB13844
The risk or severity of Tachycardia can be increased when Phentermine is combined with Pipenzolate.
DB13850
The risk or severity of Tachycardia can be increased when Phentermine is combined with Timepidium.
DB00184
The risk or severity of Tachycardia can be increased when Nicotine is combined with Phentermine.
DB00555
The risk or severity of Tachycardia can be increased when Phentermine is combined with Lamotrigine.
DB01036
The risk or severity of Tachycardia can be increased when Phentermine is combined with Tolterodine.
DB01166
The risk or severity of Tachycardia can be increased when Phentermine is combined with Cilostazol.
DB01409
The risk or severity of Tachycardia can be increased when Phentermine is combined with Tiotropium.
DB06702
The risk or severity of Tachycardia can be increased when Phentermine is combined with Fesoterodine.
DB09089
The risk or severity of Tachycardia can be increased when Phentermine is combined with Trimebutine.
DB09262
The risk or severity of Tachycardia can be increased when Phentermine is combined with Imidafenacin.
DB13500
The risk or severity of Tachycardia can be increased when Phentermine is combined with Otilonium.
DB00496
The risk or severity of Tachycardia can be increased when Phentermine is combined with Darifenacin.
DB01100
The therapeutic efficacy of Phentermine can be decreased when used in combination with Pimozide.
DB00477
The therapeutic efficacy of Phentermine can be decreased when used in combination with Chlorpromazine.
DB00745
The risk or severity of hypertension can be increased when Phentermine is combined with Modafinil.
DB06413
The risk or severity of hypertension can be increased when Phentermine is combined with Armodafinil.
DB00187
The therapeutic efficacy of Esmolol can be decreased when used in combination with Phentermine.
DB00195
The therapeutic efficacy of Betaxolol can be decreased when used in combination with Phentermine.
DB00226
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Phentermine.
DB00264
The therapeutic efficacy of Metoprolol can be decreased when used in combination with Phentermine.
DB00320
The therapeutic efficacy of Dihydroergotamine can be decreased when used in combination with Phentermine.
DB00335
The therapeutic efficacy of Atenolol can be decreased when used in combination with Phentermine.
DB00346
The therapeutic efficacy of Alfuzosin can be decreased when used in combination with Phentermine.
DB00373
The therapeutic efficacy of Timolol can be decreased when used in combination with Phentermine.
DB00392
The therapeutic efficacy of Profenamine can be decreased when used in combination with Phentermine.
DB00450
The therapeutic efficacy of Droperidol can be decreased when used in combination with Phentermine.
DB00457
The therapeutic efficacy of Prazosin can be decreased when used in combination with Phentermine.
DB00489
The therapeutic efficacy of Sotalol can be decreased when used in combination with Phentermine.
DB00571
The therapeutic efficacy of Propranolol can be decreased when used in combination with Phentermine.
DB00590
The therapeutic efficacy of Doxazosin can be decreased when used in combination with Phentermine.
DB00598
The therapeutic efficacy of Labetalol can be decreased when used in combination with Phentermine.
DB00612
The therapeutic efficacy of Bisoprolol can be decreased when used in combination with Phentermine.
DB00622
The therapeutic efficacy of Nicardipine can be decreased when used in combination with Phentermine.
DB00661
The therapeutic efficacy of Verapamil can be decreased when used in combination with Phentermine.
DB00679
The therapeutic efficacy of Thioridazine can be decreased when used in combination with Phentermine.
DB00692
The therapeutic efficacy of Phentolamine can be decreased when used in combination with Phentermine.
DB00696
The therapeutic efficacy of Ergotamine can be decreased when used in combination with Phentermine.
DB00699
The therapeutic efficacy of Nicergoline can be decreased when used in combination with Phentermine.
DB00706
The therapeutic efficacy of Tamsulosin can be decreased when used in combination with Phentermine.
DB00797
The therapeutic efficacy of Tolazoline can be decreased when used in combination with Phentermine.
DB00831
The therapeutic efficacy of Trifluoperazine can be decreased when used in combination with Phentermine.
DB00866
The therapeutic efficacy of Alprenolol can be decreased when used in combination with Phentermine.
DB00875
The therapeutic efficacy of Flupentixol can be decreased when used in combination with Phentermine.
DB00908
The therapeutic efficacy of Quinidine can be decreased when used in combination with Phentermine.
DB00925
The therapeutic efficacy of Phenoxybenzamine can be decreased when used in combination with Phentermine.
DB00960
The therapeutic efficacy of Pindolol can be decreased when used in combination with Phentermine.
DB01049
The therapeutic efficacy of Ergoloid mesylate can be decreased when used in combination with Phentermine.
DB01126
The therapeutic efficacy of Dutasteride can be decreased when used in combination with Phentermine.
DB01136
The therapeutic efficacy of Carvedilol can be decreased when used in combination with Phentermine.
DB01149
The therapeutic efficacy of Nefazodone can be decreased when used in combination with Phentermine.
DB01158
The therapeutic efficacy of Bretylium can be decreased when used in combination with Phentermine.
DB01162
The therapeutic efficacy of Terazosin can be decreased when used in combination with Phentermine.
DB01182
The therapeutic efficacy of Propafenone can be decreased when used in combination with Phentermine.
DB01193
The therapeutic efficacy of Acebutolol can be decreased when used in combination with Phentermine.
DB01203
The therapeutic efficacy of Nadolol can be decreased when used in combination with Phentermine.
DB01267
The therapeutic efficacy of Paliperidone can be decreased when used in combination with Phentermine.
DB01295
The therapeutic efficacy of Bevantolol can be decreased when used in combination with Phentermine.
DB01297
The therapeutic efficacy of Practolol can be decreased when used in combination with Phentermine.
DB01359
The therapeutic efficacy of Penbutolol can be decreased when used in combination with Phentermine.
DB01392
The therapeutic efficacy of Yohimbine can be decreased when used in combination with Phentermine.
DB01580
The therapeutic efficacy of Oxprenolol can be decreased when used in combination with Phentermine.
DB01608
The therapeutic efficacy of Periciazine can be decreased when used in combination with Phentermine.
DB01614
The therapeutic efficacy of Acepromazine can be decreased when used in combination with Phentermine.
DB01622
The therapeutic efficacy of Thioproperazine can be decreased when used in combination with Phentermine.
DB03322
The therapeutic efficacy of Dexpropranolol can be decreased when used in combination with Phentermine.
DB04581
The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Phentermine.
DB04846
The therapeutic efficacy of Celiprolol can be decreased when used in combination with Phentermine.
DB04855
The therapeutic efficacy of Dronedarone can be decreased when used in combination with Phentermine.
DB04861
The therapeutic efficacy of Nebivolol can be decreased when used in combination with Phentermine.
DB06207
The therapeutic efficacy of Silodosin can be decreased when used in combination with Phentermine.
DB06726
The therapeutic efficacy of Bufuralol can be decreased when used in combination with Phentermine.
DB08807
The therapeutic efficacy of Bopindolol can be decreased when used in combination with Phentermine.
DB08808
The therapeutic efficacy of Bupranolol can be decreased when used in combination with Phentermine.
DB08815
The therapeutic efficacy of Lurasidone can be decreased when used in combination with Phentermine.
DB08950
The therapeutic efficacy of Indoramin can be decreased when used in combination with Phentermine.
DB08952
The therapeutic efficacy of Indenolol can be decreased when used in combination with Phentermine.
DB08954
The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Phentermine.
DB09128
The therapeutic efficacy of Brexpiprazole can be decreased when used in combination with Phentermine.
DB09204
The therapeutic efficacy of Arotinolol can be decreased when used in combination with Phentermine.
DB09205
The therapeutic efficacy of Moxisylyte can be decreased when used in combination with Phentermine.
DB09206
The therapeutic efficacy of Trimazosin can be decreased when used in combination with Phentermine.
DB09239
The therapeutic efficacy of Niguldipine can be decreased when used in combination with Phentermine.
DB09351
The therapeutic efficacy of Levobetaxolol can be decreased when used in combination with Phentermine.
DB11481
The therapeutic efficacy of Atipamezole can be decreased when used in combination with Phentermine.
DB11770
The therapeutic efficacy of Talinolol can be decreased when used in combination with Phentermine.
DB11785
The therapeutic efficacy of Anisodamine can be decreased when used in combination with Phentermine.
DB12057
The therapeutic efficacy of ORM-12741 can be decreased when used in combination with Phentermine.
DB12092
The therapeutic efficacy of Naftopidil can be decreased when used in combination with Phentermine.
DB12212
The therapeutic efficacy of Landiolol can be decreased when used in combination with Phentermine.
DB12230
The therapeutic efficacy of Bunazosin can be decreased when used in combination with Phentermine.
DB12278
The therapeutic efficacy of Propiverine can be decreased when used in combination with Phentermine.
DB12551
The therapeutic efficacy of Idazoxan can be decreased when used in combination with Phentermine.
DB12661
The therapeutic efficacy of Urapidil can be decreased when used in combination with Phentermine.
DB12752
The therapeutic efficacy of Bucindolol can be decreased when used in combination with Phentermine.
DB13345
The therapeutic efficacy of Dihydroergocristine can be decreased when used in combination with Phentermine.
DB13443
The therapeutic efficacy of Esatenolol can be decreased when used in combination with Phentermine.
DB13508
The therapeutic efficacy of Cloranolol can be decreased when used in combination with Phentermine.
DB13510
The therapeutic efficacy of Buflomedil can be decreased when used in combination with Phentermine.
DB13530
The therapeutic efficacy of Mepindolol can be decreased when used in combination with Phentermine.
DB13757
The therapeutic efficacy of Epanolol can be decreased when used in combination with Phentermine.
DB13775
The therapeutic efficacy of Tertatolol can be decreased when used in combination with Phentermine.
DB00344
The therapeutic efficacy of Protriptyline can be increased when used in combination with Phentermine.
DB01242
The therapeutic efficacy of Clomipramine can be increased when used in combination with Phentermine.
DB04836
The therapeutic efficacy of Amineptine can be increased when used in combination with Phentermine.
DB08996
The therapeutic efficacy of Dimetacrine can be increased when used in combination with Phentermine.
DB09289
The therapeutic efficacy of Tianeptine can be increased when used in combination with Phentermine.
DB09307
The therapeutic efficacy of Oxaprotiline can be increased when used in combination with Phentermine.
DB12930
The therapeutic efficacy of Opipramol can be increased when used in combination with Phentermine.
DB13114
The therapeutic efficacy of Amitriptylinoxide can be increased when used in combination with Phentermine.
DB13225
The therapeutic efficacy of Dibenzepin can be increased when used in combination with Phentermine.
DB13246
The therapeutic efficacy of Quinupramine can be increased when used in combination with Phentermine.
DB13384
The therapeutic efficacy of Melitracen can be increased when used in combination with Phentermine.
DB13411
The therapeutic efficacy of Lofepramine can be increased when used in combination with Phentermine.
DB13496
The therapeutic efficacy of Iprindole can be increased when used in combination with Phentermine.
DB13782
The therapeutic efficacy of Imipramine oxide can be increased when used in combination with Phentermine.
DB00502
The therapeutic efficacy of Phentermine can be decreased when used in combination with Haloperidol.
DB14507
The therapeutic efficacy of Phentermine can be decreased when used in combination with Lithium citrate.
DB14509
The therapeutic efficacy of Phentermine can be decreased when used in combination with Lithium carbonate.
DB14506
The therapeutic efficacy of Phentermine can be decreased when used in combination with Lithium hydroxide.
DB00030
The therapeutic efficacy of Insulin human can be increased when used in combination with Phentermine.
DB00046
The therapeutic efficacy of Insulin lispro can be increased when used in combination with Phentermine.
DB00047
The therapeutic efficacy of Insulin glargine can be increased when used in combination with Phentermine.
DB00071
The therapeutic efficacy of Insulin pork can be increased when used in combination with Phentermine.
DB00197
The therapeutic efficacy of Troglitazone can be increased when used in combination with Phentermine.
DB00222
The therapeutic efficacy of Glimepiride can be increased when used in combination with Phentermine.
DB00263
The therapeutic efficacy of Sulfisoxazole can be increased when used in combination with Phentermine.
DB00280
The therapeutic efficacy of Disopyramide can be increased when used in combination with Phentermine.
DB00284
The therapeutic efficacy of Acarbose can be increased when used in combination with Phentermine.
DB00331
The therapeutic efficacy of Metformin can be increased when used in combination with Phentermine.
DB00359
The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Phentermine.
DB00412
The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Phentermine.
DB00414
The therapeutic efficacy of Acetohexamide can be increased when used in combination with Phentermine.
DB00468
The therapeutic efficacy of Quinine can be increased when used in combination with Phentermine.
DB00491
The therapeutic efficacy of Miglitol can be increased when used in combination with Phentermine.
DB00672
The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Phentermine.
DB00731
The therapeutic efficacy of Nateglinide can be increased when used in combination with Phentermine.
DB00738
The therapeutic efficacy of Pentamidine can be increased when used in combination with Phentermine.
DB00834
The therapeutic efficacy of Mifepristone can be increased when used in combination with Phentermine.
DB00839
The therapeutic efficacy of Tolazamide can be increased when used in combination with Phentermine.
DB00912
The therapeutic efficacy of Repaglinide can be increased when used in combination with Phentermine.
DB00914
The therapeutic efficacy of Phenformin can be increased when used in combination with Phentermine.
DB01015
The therapeutic efficacy of Sulfamethoxazole can be increased when used in combination with Phentermine.
DB01016
The therapeutic efficacy of Glyburide can be increased when used in combination with Phentermine.
DB01067
The therapeutic efficacy of Glipizide can be increased when used in combination with Phentermine.
DB01120
The therapeutic efficacy of Gliclazide can be increased when used in combination with Phentermine.
DB01124
The therapeutic efficacy of Tolbutamide can be increased when used in combination with Phentermine.
DB01132
The therapeutic efficacy of Pioglitazone can be increased when used in combination with Phentermine.
DB01200
The therapeutic efficacy of Bromocriptine can be increased when used in combination with Phentermine.
DB01251
The therapeutic efficacy of Gliquidone can be increased when used in combination with Phentermine.
DB01252
The therapeutic efficacy of Mitiglinide can be increased when used in combination with Phentermine.
DB01261
The therapeutic efficacy of Sitagliptin can be increased when used in combination with Phentermine.
DB01268
The therapeutic efficacy of Sunitinib can be increased when used in combination with Phentermine.
DB01276
The therapeutic efficacy of Exenatide can be increased when used in combination with Phentermine.
DB01277
The therapeutic efficacy of Mecasermin can be increased when used in combination with Phentermine.
DB01278
The therapeutic efficacy of Pramlintide can be increased when used in combination with Phentermine.
DB01289
The therapeutic efficacy of Glisoxepide can be increased when used in combination with Phentermine.
DB01306
The therapeutic efficacy of Insulin aspart can be increased when used in combination with Phentermine.
DB01307
The therapeutic efficacy of Insulin detemir can be increased when used in combination with Phentermine.
DB01309
The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Phentermine.
DB01382
The therapeutic efficacy of Glymidine can be increased when used in combination with Phentermine.
DB01700
The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Phentermine.
DB04830
The therapeutic efficacy of Buformin can be increased when used in combination with Phentermine.
DB04876
The therapeutic efficacy of Vildagliptin can be increased when used in combination with Phentermine.
DB04878
The therapeutic efficacy of Voglibose can be increased when used in combination with Phentermine.
DB05115
The therapeutic efficacy of NN344 can be increased when used in combination with Phentermine.
DB05819
The therapeutic efficacy of NBI-6024 can be increased when used in combination with Phentermine.
DB06011
The therapeutic efficacy of AMG-222 can be increased when used in combination with Phentermine.
DB06127
The therapeutic efficacy of Bisegliptin can be increased when used in combination with Phentermine.
DB06203
The therapeutic efficacy of Alogliptin can be increased when used in combination with Phentermine.
DB06292
The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Phentermine.
DB06335
The therapeutic efficacy of Saxagliptin can be increased when used in combination with Phentermine.
DB06655
The therapeutic efficacy of Liraglutide can be increased when used in combination with Phentermine.
DB08382
The therapeutic efficacy of Gosogliptin can be increased when used in combination with Phentermine.
DB08882
The therapeutic efficacy of Linagliptin can be increased when used in combination with Phentermine.
DB08907
The therapeutic efficacy of Canagliflozin can be increased when used in combination with Phentermine.
DB08962
The therapeutic efficacy of Glibornuride can be increased when used in combination with Phentermine.
DB09022
The therapeutic efficacy of Benfluorex can be increased when used in combination with Phentermine.
DB09038
The therapeutic efficacy of Empagliflozin can be increased when used in combination with Phentermine.
DB09043
The therapeutic efficacy of Albiglutide can be increased when used in combination with Phentermine.
DB09045
The therapeutic efficacy of Dulaglutide can be increased when used in combination with Phentermine.
DB09198
The therapeutic efficacy of Lobeglitazone can be increased when used in combination with Phentermine.
DB09199
The therapeutic efficacy of Netoglitazone can be increased when used in combination with Phentermine.
DB09200
The therapeutic efficacy of Rivoglitazone can be increased when used in combination with Phentermine.
DB09201
The therapeutic efficacy of Ciglitazone can be increased when used in combination with Phentermine.
DB09265
The therapeutic efficacy of Lixisenatide can be increased when used in combination with Phentermine.
DB09456
The therapeutic efficacy of Insulin beef can be increased when used in combination with Phentermine.
DB09564
The therapeutic efficacy of Insulin degludec can be increased when used in combination with Phentermine.
DB11567
The therapeutic efficacy of Insulin peglispro can be increased when used in combination with Phentermine.
DB11568
The therapeutic efficacy of Insulin tregopil can be increased when used in combination with Phentermine.
DB11698
The therapeutic efficacy of Ipragliflozin can be increased when used in combination with Phentermine.
DB11723
The therapeutic efficacy of Dutogliptin can be increased when used in combination with Phentermine.
DB11780
The therapeutic efficacy of Allicin can be increased when used in combination with Phentermine.
DB11824
The therapeutic efficacy of Tofogliflozin can be increased when used in combination with Phentermine.
DB11827
The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Phentermine.
DB11898
The therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Phentermine.
DB11950
The therapeutic efficacy of Teneligliptin can be increased when used in combination with Phentermine.
DB11992
The therapeutic efficacy of Omarigliptin can be increased when used in combination with Phentermine.
DB12268
The therapeutic efficacy of Carmegliptin can be increased when used in combination with Phentermine.
DB12412
The therapeutic efficacy of Gemigliptin can be increased when used in combination with Phentermine.
DB12417
The therapeutic efficacy of Anagliptin can be increased when used in combination with Phentermine.
DB12625
The therapeutic efficacy of Evogliptin can be increased when used in combination with Phentermine.
DB12713
The therapeutic efficacy of Sotagliflozin can be increased when used in combination with Phentermine.
DB12781
The therapeutic efficacy of Balaglitazone can be increased when used in combination with Phentermine.
DB12935
The therapeutic efficacy of Remogliflozin etabonate can be increased when used in combination with Phentermine.
DB13406
The therapeutic efficacy of Carbutamide can be increased when used in combination with Phentermine.
DB13446
The therapeutic efficacy of Guar gum can be increased when used in combination with Phentermine.
DB13675
The therapeutic efficacy of Metahexamide can be increased when used in combination with Phentermine.
DB13928
The therapeutic efficacy of Semaglutide can be increased when used in combination with Phentermine.
DB14027
The therapeutic efficacy of Taspoglutide can be increased when used in combination with Phentermine.
DB14035
The therapeutic efficacy of Englitazone can be increased when used in combination with Phentermine.
DB15171
The therapeutic efficacy of Tirzepatide can be increased when used in combination with Phentermine.
DB15217
The therapeutic efficacy of Gastric inhibitory polypeptide can be increased when used in combination with Phentermine.
DB00017
The risk or severity of adverse effects can be increased when Phentermine is combined with Salmon calcitonin.
DB00024
The risk or severity of adverse effects can be increased when Phentermine is combined with Thyrotropin alfa.
DB00066
The risk or severity of adverse effects can be increased when Phentermine is combined with Follitropin.
DB00279
The risk or severity of adverse effects can be increased when Phentermine is combined with Liothyronine.
DB00389
The risk or severity of adverse effects can be increased when Phentermine is combined with Carbimazole.
DB00550
The risk or severity of adverse effects can be increased when Phentermine is combined with Propylthiouracil.
DB01583
The risk or severity of adverse effects can be increased when Phentermine is combined with Liotrix.
DB03374
The risk or severity of adverse effects can be increased when Phentermine is combined with 3,5-Diiodotyrosine.
DB03604
The risk or severity of adverse effects can be increased when Phentermine is combined with Tiratricol.
DB05084
The risk or severity of adverse effects can be increased when Phentermine is combined with Abaloparatide.
DB05829
The risk or severity of adverse effects can be increased when Phentermine is combined with Parathyroid hormone.
DB06285
The risk or severity of adverse effects can be increased when Phentermine is combined with Teriparatide.
DB06715
The risk or severity of adverse effects can be increased when Phentermine is combined with Potassium Iodide.
DB07637
The risk or severity of adverse effects can be increased when Phentermine is combined with Dibromotyrosine.
DB09100
The risk or severity of adverse effects can be increased when Phentermine is combined with Thyroid, porcine.
DB09418
The risk or severity of adverse effects can be increased when Phentermine is combined with Potassium perchlorate.
DB09421
The risk or severity of adverse effects can be increased when Phentermine is combined with Protirelin.
DB12629
The risk or severity of adverse effects can be increased when Phentermine is combined with 3,5-diiodothyropropionic acid.
DB13644
The risk or severity of adverse effects can be increased when Phentermine is combined with Methylthiouracil.
DB13742
The risk or severity of adverse effects can be increased when Phentermine is combined with Elcatonin.
DB13804
The risk or severity of adverse effects can be increased when Phentermine is combined with Benzylthiouracil.
DB15263
The risk or severity of adverse effects can be increased when Phentermine is combined with Thyrotropin.
DB00451
The risk or severity of adverse effects can be increased when Phentermine is combined with Levothyroxine.
DB11823
The risk or severity of hypertension can be increased when Esketamine is combined with Phentermine.
DB14754
The risk or severity of hypertension can be increased when Solriamfetol is combined with Phentermine.
DB13946
Testosterone undecanoate may increase the hypertensive activities of Phentermine.
DB00454
The therapeutic efficacy of Meperidine can be increased when used in combination with Phentermine.
DB00956
The risk or severity of serotonin syndrome can be increased when Hydrocodone is combined with Phentermine.
DB00656
The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Phentermine.
DB01175
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Escitalopram.
DB11732
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Lasmiditan.
DB06119
The serum concentration of Phentermine can be decreased when it is combined with Cenobamate.
DB00193
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Tramadol.
DB00503
The serum concentration of Phentermine can be increased when it is combined with Ritonavir.
DB11652
The metabolism of Tucatinib can be decreased when combined with Phentermine.
DB00472
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Fluoxetine.
DB00574
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Fenfluramine.
DB00819
Acetazolamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
DB11932
The serum concentration of Phentermine can be increased when it is combined with Abametapir.
DB14881
The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Oliceridine.
DB15762
The serum concentration of Phentermine can be decreased when it is combined with Satralizumab.
序列
实验性质
Water Solubility
18.6 g/L
Gravey W. (2013). Expert Opin Drug Saf.
Melting Point
205 °C
'MSDS'
Boiling Point
206 ºC
Barceloux D. (2012). Medical Toxicology of Drug Abuse.
logP
1.90
Barceloux D. (2012). Medical Toxicology of Drug Abuse.
pKa
9.84
Suprenza - package insert. (2014)
外部标识符
resource:Drugs Product Database (DPD)
identifier:20320
resource:Drugs Product Database (DPD)
identifier:8289
resource:ChEBI
identifier:8080
resource:PubChem Compound
identifier:4771
resource:PubChem Substance
identifier:46508515
resource:KEGG Compound
identifier:C07438
resource:KEGG Drug
identifier:D05458
resource:ChemSpider
identifier:4607
resource:BindingDB
identifier:50246598
resource:PharmGKB
identifier:PA164748099
resource:Therapeutic Targets Database
identifier:DAP000719
resource:Wikipedia
identifier:Phentermine
resource:ChEMBL
identifier:CHEMBL1574
resource:ZINC
identifier:ZINC000008403947
resource:RxCUI
identifier:221138
外部链接
RxList
http://www.rxlist.com/cgi/generic/phenterm.htm
Drugs.com
http://www.drugs.com/phentermine.html
路径
目标
id:BE0000486
name:Sodium-dependent noradrenaline transporter
organism:Humans
action:inhibitor
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Stephens LC, Katz SG: Phentermine and anaesthesia. Anaesth Intensive Care. 2005 Aug;33(4):525-7.
Samanin R, Garattini S: Neurochemical mechanism of action of anorectic drugs. Pharmacol Toxicol. 1993 Aug;73(2):63-8.
Proietto J, Fam BC, Ainslie DA, Thorburn AW: Novel anti-obesity drugs. Expert Opin Investig Drugs. 2000 Jun;9(6):1317-26.
known-action:yes
name:Sodium-dependent noradrenaline transporter
general-function:Norepinephrine:sodium symporter activity
specific-function:Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
gene-name:SLC6A2
locus:16q12.2
cellular-location:Membrane
transmembrane-regions:65-85 93-112 136-156 235-253 262-279 315-332 344-365 398-417 444-462 478-498 519-538 557-575
signal-regions:
theoretical-pi:7.53
molecular-weight:69331.42
chromosome-location:16
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:11048GenAtlasSLC6A2GenBank Gene DatabaseM65105GenBank Protein Database189258Guide to Pharmacology926UniProtKBP23975UniProt AccessionSC6A2_HUMAN
synonyms:NAT1NETNET1Norepinephrine transporterSLC6A5Solute carrier family 6 member 2
amino-acid-sequence:>lcl|BSEQ0000970|Sodium-dependent noradrenaline transporter MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL VAQRDIRQFQLQHWLAI
gene-sequence:>lcl|BSEQ0010343|Sodium-dependent noradrenaline transporter (SLC6A2) ATGCTTCTGGCGCGGATGAACCCGCAGGTGCAGCCCGAGAACAACGGGGCGGACACGGGT CCAGAGCAGCCCCTTCGGGCGCGCAAAACTGCGGAGCTGCTGGTGGTGAAGGAGCGCAAC GGCGTCCAGTGCCTGCTGGCGCCCCGCGACGGCGACGCGCAGCCCCGGGAGACCTGGGGC AAGAAGATCGACTTCCTGCTGTCCGTAGTCGGCTTCGCAGTGGACCTGGCCAACGTGTGG CGCTTCCCCTACCTCTGCTACAAGAACGGCGGCGGTGCCTTCTTGATCCCGTACACACTG TTCCTTATCATCGCGGGGATGCCCCTGTTCTACATGGAGCTGGCTCTGGGACAGTACAAC CGGGAGGGGGCTGCCACCGTTTGGAAAATCTGCCCATTCTTCAAAGGCGTTGGCTATGCT GTCATCCTGATCGCCCTGTACGTTGGCTTCTACTACAACGTCATCATCGCCTGGTCACTC TACTACCTCTTCTCCTCCTTCACCCTCAACCTGCCCTGGACCGACTGTGGCCACACCTGG AACAGCCCCAACTGTACCGACCCCAAGCTCCTCAATGGCTCCGTGCTTGGCAACCACACC AAGTACTCCAAGTACAAGTTCACGCCGGCAGCCGAGTTTTATGAGCGTGGTGTCCTGCAC CTTCACGAGAGCAGCGGGATTCATGACATCGGCCTGCCCCAGTGGCAGCTCTTGCTCTGT CTGATGGTCGTCGTCATCGTCTTGTATTTTAGCCTCTGGAAAGGGGTGAAGACATCAGGA AAGGTGGTGTGGATCACAGCCACGCTGCCTTACTTCGTGCTGTTCGTGCTCCTGGTCCAT GGCGTCACGCTGCCCGGAGCCTCCAATGGCATCAATGCCTACCTGCACATCGACTTCTAC CGCTTGAAAGAGGCCACGGTATGGATTGATGCCGCAACTCAGATATTTTTTTCCTTGGGG GCTGGATTTGGAGTATTGATTGCATTTGCCAGTTACAACAAATTTGACAACAACTGTTAC AGGGATGCCCTGCTGACCAGCAGCATCAACTGTATCACCAGCTTCGTCTCTGGGTTCGCC ATCTTCTCCATCCTTGGTTACATGGCCCATGAACACAAGGTCAACATTGAGGATGTGGCC ACAGAAGGAGCTGGCCTAGTGTTCATCCTGTATCCAGAGGCCATTTCTACCCTGTCTGGA TCTACATTCTGGGCTGTTGTGTTTTTCGTCATGCTCCTGGCGCTGGGCCTTGACAGCTCA ATGGGAGGCATGGAGGCTGTCATCACGGGCCTGGCAGATGACTTCCAGGTCCTGAAGCGA CACCGGAAACTCTTCACATTTGGCGTCACCTTCAGCACTTTCCTTCTCGCCCTGTTCTGC ATAACCAAGGGTGGAATTTACGTCTTGACCCTCCTGGACACCTTTGCTGCGGGCACCTCC ATCCTTTTTGCTGTCCTCATGGAAGCCATCGGAGTTTCCTGGTTTTATGGAGTGGACAGG TTCAGCAACGACATCCAGCAGATGATGGGGTTCAGGCCGGGTCTATACTGGAGACTGTGC TGGAAGTTCGTCAGTCCTGCCTTCCTCCTGTTCGTGGTTGTGGTCAGCATCATCAACTTC AAGCCACTCACCTACGACGACTACATCTTCCCGCCCTGGGCCAACTGGGTGGGGTGGGGC ATCGCCCTGTCCTCCATGGTCCTGGTGCCCATCTACGTCATCTATAAGTTCCTCAGCACG CAGGGCTCTCTTTGGGAGAGACTGGCCTATGGCATCACGCCAGAGAACGAGCACCACCTG GTGGCTCAGAGGGACATCAGACAGTTCCAGTTGCAACACTGGCTGGCCATCTGA
pfams:PF00209SNF
go-classifiers:componentintegral component of plasma membranecomponentmembranecomponentneuron projectioncomponentplasma membranefunctionmonoamine transmembrane transporter activityfunctionnorepinephrineprocessmonoamine transportprocessnorepinephrine transportprocessresponse to painprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
id:BE0000749
name:Sodium-dependent serotonin transporter
organism:Humans
action:inhibitor
John CE, Jones SR: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun;52(8):1596-605. Epub 2007 Mar 16.
Johnson GJ, Leis LA, Dunlop PC, Weir EK: The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost. 2003 Dec;1(12):2663-8.
Mekontso-Dessap A, Brouri F, Pascal O, Lechat P, Hanoun N, Lanfumey L, Seif I, Benhaiem-Sigaux N, Kirsch M, Hamon M, Adnot S, Eddahibi S: Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation. 2006 Jan 3;113(1):81-9. Epub 2005 Dec 27.
Rothman RB, Ayestas MA, Dersch CM, Baumann MH: Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug 24;100(8):869-75.
Zolkowska D, Rothman RB, Baumann MH: Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. J Pharmacol Exp Ther. 2006 Aug;318(2):604-10. Epub 2006 Apr 27.
known-action:yes
name:Sodium-dependent serotonin transporter
general-function:Serotonin:sodium symporter activity
specific-function:Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
gene-name:SLC6A4
locus:17q11.1-q12
cellular-location:Cell membrane
transmembrane-regions:88-108 116-135 160-180 253-271 280-297 333-350 362-383 417-436 464-482 498-518 539-558 577-595
signal-regions:
theoretical-pi:6.17
molecular-weight:70324.165
chromosome-location:17
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:11050GenAtlasSLC6A4GenBank Gene DatabaseX70697GenBank Protein Database36433Guide to Pharmacology928UniProtKBP31645UniProt AccessionSC6A4_HUMAN
synonyms:5HT transporter5HTTHTTSERTSolute carrier family 6 member 4
amino-acid-sequence:>lcl|BSEQ0001494|Sodium-dependent serotonin transporter METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT PGTFKERIIKSITPETPTEIPCGDIRLNAV
gene-sequence:>lcl|BSEQ0021275|Sodium-dependent serotonin transporter (SLC6A4) ATGGAGACGACGCCCTTGAATTCTCAGAAGCAGCTATCAGCGTGTGAAGATGGAGAAGAT TGTCAGGAAAACGGAGTTCTACAGAAGGTTGTTCCCACCCCAGGGGACAAAGTGGAGTCC GGGCAAATATCCAATGGGTACTCAGCAGTTCCAAGTCCTGGTGCGGGAGATGACACACGG CACTCTATCCCAGCGACCACCACCACCCTAGTGGCTGAGCTTCATCAAGGGGAACGGGAG ACCTGGGGCAAGAAGGTGGATTTCCTTCTCTCAGTGATTGGCTATGCTGTGGACCTGGGC AATGTCTGGCGCTTCCCCTACATATGTTACCAGAATGGAGGGGGGGCATTCCTCCTCCCC TACACCATCATGGCCATTTTTGGGGGAATCCCGCTCTTTTACATGGAGCTCGCACTGGGA CAGTACCACCGAAATGGATGCATTTCAATATGGAGGAAAATCTGCCCGATTTTCAAAGGG ATTGGTTATGCCATCTGCATCATTGCCTTTTACATTGCTTCCTACTACAACACCATCATG GCCTGGGCGCTATACTACCTCATCTCCTCCTTCACGGACCAGCTGCCCTGGACCAGCTGC AAGAACTCCTGGAACACTGGCAACTGCACCAATTACTTCTCCGAGGACAACATCACCTGG ACCCTCCATTCCACGTCCCCTGCTGAAGAATTTTACACGCGCCACGTCCTGCAGATCCAC CGGTCTAAGGGGCTCCAGGACCTGGGGGGCATCAGCTGGCAGCTGGCCCTCTGCATCATG CTGATCTTCACTGTTATCTACTTCAGCATCTGGAAAGGCGTCAAGACCTCTGGCAAGGTG GTGTGGGTGACAGCCACCTTCCCTTATATCATCCTTTCTGTCCTGCTGGTGAGGGGTGCC ACCCTCCCTGGAGCCTGGAGGGGTGTTCTCTTCTACTTGAAACCCAATTGGCAGAAACTC CTGGAGACAGGGGTGTGGATAGATGCAGCCGCTCAGATCTTCTTCTCTCTTGGTCCGGGC TTTGGGGTCCTGCTGGCTTTTGCTAGCTACAACAAGTTCAACAACAACTGCTACCAAGAT GCCCTGGTGACCAGCGTGGTGAACTGCATGACGAGCTTCGTTTCGGGATTTGTCATCTTC ACAGTGCTCGGTTACATGGCTGAGATGAGGAATGAAGATGTGTCTGAGGTGGCCAAAGAC GCAGGTCCCAGCCTCCTCTTCATCACGTATGCAGAAGCGATAGCCAACATGCCAGCGTCC ACTTTCTTTGCCATCATCTTCTTTCTGATGTTAATCACGCTGGGCTTGGACAGCACGTTT GCAGGCTTGGAGGGGGTGATCACGGCTGTGCTGGATGAGTTCCCACACGTCTGGGCCAAG CGCCGGGAGCGGTTCGTGCTCGCCGTGGTCATCACCTGCTTCTTTGGATCCCTGGTCACC CTGACTTTTGGAGGGGCCTACGTGGTGAAGCTGCTGGAGGAGTATGCCACGGGGCCCGCA GTGCTCACTGTCGCGCTGATCGAAGCAGTCGCTGTGTCTTGGTTCTATGGCATCACTCAG TTCTGCAGGGACGTGAAGGAAATGCTCGGCTTCAGCCCGGGGTGGTTCTGGAGGATCTGC TGGGTGGCCATCAGCCCTCTGTTTCTCCTGTTCATCATTTGCAGTTTTCTGATGAGCCCG CCACAACTACGACTTTTCCAATATAATTATCCTTACTGGAGTATCATCTTGGGTTACTGC ATAGGAACCTCATCTTTCATTTGCATCCCCACATATATAGCTTATCGGTTGATCATCACT CCAGGGACATTTAAAGAGCGTATTATTAAAAGTATTACCCCAGAAACACCAACAGAAATT CCTTGTGGGGACATCCGCTTGAATGCTGTGTAA
pfams:PF00209SNFPF034915HT_transport_N
go-classifiers:componentcytosolcomponentendomembrane systemcomponentendosome membranecomponentintegral component of plasma membranecomponentmembrane raftcomponentneuron projectioncomponentplasma membranefunctionactin filament bindingfunctioncocaine bindingfunctionmonoamine transmembrane transporter activityfunctionRab GTPase bindingfunctionserotoninfunctionserotonin transmembrane transporter activityprocessbrain morphogenesisprocesscellular response to cGMPprocesscellular response to retinoic acidprocesscircadian rhythmprocessmemoryprocessmonoamine transportprocessnegative regulation of cerebellar granule cell precursor proliferationprocessnegative regulation of neuron differentiationprocessnegative regulation of organ growthprocessnegative regulation of synaptic transmission, dopaminergicprocesspositive regulation of cell cycleprocesspositive regulation of gene expressionprocessprotein homooligomerizationprocessprotein oligomerizationprocessresponse to drugprocessresponse to estradiolprocessresponse to hypoxiaprocessresponse to nutrientprocessresponse to toxic substanceprocessserotonin transportprocessserotonin uptakeprocesssocial behaviorprocesssperm ejaculationprocesssynaptic transmissionprocessthalamus developmentprocessvasoconstriction
id:BE0000647
name:Sodium-dependent dopamine transporter
organism:Humans
action:inhibitor
John CE, Jones SR: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun;52(8):1596-605. Epub 2007 Mar 16.
Gruner JA, Marcy VR, Lin YG, Bozyczko-Coyne D, Marino MJ, Gasior M: The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep. 2009 Nov;32(11):1425-38.
known-action:yes
name:Sodium-dependent dopamine transporter
general-function:Monoamine transmembrane transporter activity
specific-function:Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
gene-name:SLC6A3
locus:5p15.3
cellular-location:Cell membrane
transmembrane-regions:69-89 96-116 140-160 238-256 265-282 318-335 347-368 401-420 447-465 481-501 522-541 560-578
signal-regions:
theoretical-pi:6.92
molecular-weight:68494.255
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:11049GenAtlasSLC6A3GenBank Gene DatabaseM96670GenBank Protein Database553260Guide to Pharmacology927UniProtKBQ01959UniProt AccessionSC6A3_HUMAN
synonyms:DA transporterDAT1Solute carrier family 6 member 3
amino-acid-sequence:>lcl|BSEQ0010450|Sodium-dependent dopamine transporter MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD RELVDRGEVRQFTLRHWLKV
gene-sequence:>lcl|BSEQ0010451|Sodium-dependent dopamine transporter (SLC6A3) ATGAGTAAGAGCAAATGCTCCGTGGGACTCATGTCTTCCGTGGTGGCCCCGGCTAAGGAG CCCAATGCCGTGGGCCCGAAGGAGGTGGAGCTCATCCTTGTCAAGGAGCAGAACGGAGTG CAGCTCACCAGCTCCACCCTCACCAACCCGCGGCAGAGCCCCGTGGAGGCCCAGGATCGG GAGACCTGGGGCAAGAAGATCGACTTTCTCCTGTCCGTCATTGGCTTTGCTGTGGACCTG GCCAACGTCTGGCGGTTCCCCTACCTGTGCTACAAAAATGGTGGCGGTGCCTTCCTGGTC CCCTACCTGCTCTTCATGGTCATTGCTGGGATGCCACTTTTCTACATGGAGCTGGCCCTC GGCCAGTTCAACAGGGAAGGGGCCGCTGGTGTCTGGAAGATCTGCCCCATACTGAAAGGT GTGGGCTTCACGGTCATCCTCATCTCACTGTATGTCGGCTTCTTCTACAACGTCATCATC GCCTGGGCGCTGCACTATCTCTTCTCCTCCTTCACCACGGAGCTCCCCTGGATCCACTGC AACAACTCCTGGAACAGCCCCAACTGCTCGGATGCCCATCCTGGTGACTCCAGTGGAGAC AGCTCGGGCCTCAACGACACTTTTGGGACCACACCTGCTGCCGAGTACTTTGAACGTGGC GTGCTGCACCTCCACCAGAGCCATGGCATCGACGACCTGGGGCCTCCGCGGTGGCAGCTC ACAGCCTGCCTGGTGCTGGTCATCGTGCTGCTCTACTTCAGCCTCTGGAAGGGCGTGAAG ACCTCAGGGAAGGTGGTATGGATCACAGCCACCATGCCATACGTGGTCCTCACTGCCCTG CTCCTGCGTGGGGTCACCCTCCCTGGAGCCATAGACGGCATCAGAGCATACCTGAGCGTT GACTTCTACCGGCTCTGCGAGGCGTCTGTTTGGATTGACGCGGCCACCCAGGTGTGCTTC TCCCTGGGCGTGGGGTTCGGGGTGCTGATCGCCTTCTCCAGCTACAACAAGTTCACCAAC AACTGCTACAGGGACGCGATTGTCACCACCTCCATCAACTCCCTGACGAGCTTCTCCTCC GGCTTCGTCGTCTTCTCCTTCCTGGGGTACATGGCACAGAAGCACAGTGTGCCCATCGGG GACGTGGCCAAGGACGGGCCAGGGCTGATCTTCATCATCTACCCGGAAGCCATCGCCACG CTCCCTCTGTCCTCAGCCTGGGCCGTGGTCTTCTTCATCATGCTGCTCACCCTGGGTATC GACAGCGCCATGGGTGGTATGGAGTCAGTGATCACCGGGCTCATCGATGAGTTCCAGCTG CTGCACAGACACCGTGAGCTCTTCACGCTCTTCATCGTCCTGGCGACCTTCCTCCTGTCC CTGTTCTGCGTCACCAACGGTGGCATCTACGTCTTCACGCTCCTGGACCATTTTGCAGCC GGCACGTCCATCCTCTTTGGAGTGCTCATCGAAGCCATCGGAGTGGCCTGGTTCTATGGT GTTGGGCAGTTCAGCGACGACATCCAGCAGATGACCGGGCAGCGGCCCAGCCTGTACTGG CGGCTGTGCTGGAAGCTGGTCAGCCCCTGCTTTCTCCTGTTCGTGGTCGTGGTCAGCATT GTGACCTTCAGACCCCCCCACTACGGAGCCTACATCTTCCCCGACTGGGCCAACGCGCTG GGCTGGGTCATCGCCACATCCTCCATGGCCATGGTGCCCATCTATGCGGCCTACAAGTTC TGCAGCCTGCCTGGGTCCTTTCGAGAGAAACTGGCCTACGCCATTGCACCCGAGAAGGAC CGTGAGCTGGTGGACAGAGGGGAGGTGCGCCAGTTCACGCTCCGCCACTGGCTCAAGGTG TAG
pfams:PF00209SNF
go-classifiers:componentaxoncomponentcell surfacecomponentcytoplasmcomponentflotillin complexcomponentintegral component of membranecomponentintegral component of plasma membranecomponentneuronal cell bodycomponentplasma membranefunctiondopaminefunctiondopamine bindingfunctiondopamine transmembrane transporter activityfunctionmonoamine transmembrane transporter activityprocessadenohypophysis developmentprocessammonium transmembrane transportprocessdopamine biosynthetic processprocessdopamine catabolic processprocessdopamine transportprocessdopamine uptake involved in synaptic transmissionprocesslactationprocesslocomotory behaviorprocessmonoamine transportprocessneurotransmitter biosynthetic processprocesspositive regulation of multicellular organism growthprocessprepulse inhibitionprocessregulation of dopamine metabolic processprocessresponse to cocaineprocesssensory perception of smellprocesssynaptic transmissionprocesstransmembrane transport
id:BE0002198
name:Amine oxidase [flavin-containing] A
organism:Humans
action:antagonist
Rothman RB: Is phentermine an inhibitor of monoamine oxidase? A critical appraisal. Synapse. 1999 May;32(2):141-5.
Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21.
Kilpatrick IC, Traut M, Heal DJ: Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1454-8.
Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9.
known-action:yes
name:Amine oxidase [flavin-containing] A
general-function:Serotonin binding
specific-function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
gene-name:MAOA
locus:Xp11.3
cellular-location:Mitochondrion outer membrane
transmembrane-regions:498-518
signal-regions:
theoretical-pi:7.96
molecular-weight:59681.27
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:6833GenAtlasMAOAGenBank Gene DatabaseM68840GenBank Protein Database187353Guide to Pharmacology2489UniProtKBP21397UniProt AccessionAOFA_HUMAN
synonyms:1.4.3.4MAO-AMonoamine oxidase type A
amino-acid-sequence:>lcl|BSEQ0004313|Amine oxidase [flavin-containing] A MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
gene-sequence:>lcl|BSEQ0011589|Amine oxidase [flavin-containing] A (MAOA) ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC AAGCCAGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA TACAAGCTCCTGCCACGGTCTTGA
pfams:PF01593Amino_oxidase
go-classifiers:componentintegral component of membranecomponentmitochondrial outer membranecomponentmitochondrionfunctionflavin adenine dinucleotide bindingfunctionprimary amine oxidase activityfunctionserotonin bindingprocesscellular biogenic amine metabolic processprocessdopamine catabolic processprocessneurotransmitter biosynthetic processprocessneurotransmitter catabolic processprocessneurotransmitter secretionprocessphenylethylamine metabolic processprocessserotonin metabolic processprocesssmall molecule metabolic processprocesssynaptic transmissionprocessxenobiotic metabolic process
id:BE0002196
name:Amine oxidase [flavin-containing] B
organism:Humans
action:antagonist
Rothman RB: Does phentermine inhibit monoamine oxidase? Lancet. 1999 Apr 17;353(9161):1362-3.
Rothman RB: Is phentermine an inhibitor of monoamine oxidase? A critical appraisal. Synapse. 1999 May;32(2):141-5.
Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21.
Kilpatrick IC, Traut M, Heal DJ: Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1454-8.
Nandigama RK, Newton-Vinson P, Edmondson DE: Phentermine inhibition of recombinant human liver monoamine oxidases A and B. Biochem Pharmacol. 2002 Mar 1;63(5):865-9.
known-action:yes
name:Amine oxidase [flavin-containing] B
general-function:Primary amine oxidase activity
specific-function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
gene-name:MAOB
locus:Xp11.23
cellular-location:Mitochondrion outer membrane
transmembrane-regions:490-516
signal-regions:
theoretical-pi:7.55
molecular-weight:58762.475
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:6834GenAtlasMAOBGenBank Gene DatabaseS62734GenBank Protein Database398415Guide to Pharmacology2490UniProtKBP27338UniProt AccessionAOFB_HUMAN
synonyms:1.4.3.4MAO-BMonoamine oxidase type B
amino-acid-sequence:>lcl|BSEQ0004309|Amine oxidase [flavin-containing] B MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
gene-sequence:>lcl|BSEQ0016709|Amine oxidase [flavin-containing] B (MAOB) ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC TAA
pfams:PF01593Amino_oxidase
go-classifiers:componentextracellular exosomecomponentintegral component of membranecomponentmitochondrial envelopecomponentmitochondrial inner membranecomponentmitochondrial outer membranecomponentmitochondrionfunctionelectron carrier activityfunctionflavin adenine dinucleotide bindingfunctionprimary amine oxidase activityprocessdopamine catabolic processprocesshydrogen peroxide biosynthetic processprocessnegative regulation of serotonin secretionprocesspositive regulation of dopamine metabolic processprocessresponse to aluminum ionprocessresponse to corticosteroneprocessresponse to drugprocessresponse to ethanolprocessresponse to lipopolysaccharideprocessresponse to selenium ionprocessresponse to toxic substanceprocesssmall molecule metabolic processprocesssubstantia nigra developmentprocessxenobiotic metabolic process
id:BE0003476
name:Pro-neuropeptide Y
organism:Humans
action:inhibitor
May S. (2009). Weight-Loss Drugs. Chelsea House Publishers.
known-action:yes
name:Pro-neuropeptide Y
general-function:Receptor binding
specific-function:NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
gene-name:NPY
locus:
cellular-location:Secreted
transmembrane-regions:
signal-regions:1-28
theoretical-pi:7.34
molecular-weight:10851.29
chromosome-location:7
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:7955GenAtlasNPYGenBank Gene DatabaseBC029497UniProtKBP01303UniProt AccessionNPY_HUMAN
synonyms:CPON
amino-acid-sequence:>lcl|BSEQ0019427|Pro-neuropeptide Y MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLIT RQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW
gene-sequence:>lcl|BSEQ0019428|Pro-neuropeptide Y (NPY) ATGCTAGGTAACAAGCGACTGGGGCTGTCCGGACTGACCCTCGCCCTGTCCCTGCTCGTG TGCCTGGGTGCGCTGGCCGAGGCGTACCCCTCCAAGCCGGACAACCCGGGCGAGGACGCA CCAGCGGAGGACATGGCCAGATACTACTCGGCGCTGCGACACTACATCAACCTCATCACC AGGCAGAGATATGGAAAACGATCCAGCCCAGAGACACTGATTTCAGACCTCTTGATGAGA GAAAGCACAGAAAATGTTCCCAGAACTCGGCTTGAAGACCCTGCAATGTGGTGA
pfams:PF00159Hormone_3
go-classifiers:componentcellcomponentextracellular regioncomponentextracellular spacecomponentGolgi apparatusfunctioncalcium channel regulator activityfunctionG-protein coupled receptor activityfunctionneuropeptide hormone activityfunctionneuropeptide Y receptor bindingfunctionreceptor bindingprocessadult feeding behaviorprocessantibacterial humoral responseprocessantifungal humoral responseprocessbehaviorprocessblood circulationprocesscalcium ion transportprocesscell proliferationprocesscentral nervous system neuron developmentprocesscerebral cortex developmentprocessdefense response to Gram-negative bacteriumprocessdefense response to Gram-positive bacteriumprocessdigestionprocessfeeding behaviorprocessG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerprocessinnate immune responseprocessmovement of cell or subcellular componentprocessneuron projection developmentprocessneuropeptide signaling pathwayprocesspositive regulation of appetiteprocessregulation of appetiteprocessregulation of blood pressureprocessresponse to yeastprocesssynaptic transmission
BE0002638Cytochrome P450 3A4HumanssubstrateF3283QSYMIA (phentermine/topiramate) FDA label//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/283/original/fda.pdf?1549057509noCytochrome P450 3A4Vitamin d3 25-hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).CYP3A47q21.1Endoplasmic reticulum membrane2-228.2557342.677HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2637GenAtlasCYP3A4GenBank Gene DatabaseM18907Guide to Pharmacology1337UniProtKBP08684UniProt AccessionCP3A4_HUMAN1,8-cineole 2-exo-monooxygenase1.14.13.-Albendazole monooxygenaseAlbendazole sulfoxidaseCholesterol 25-hydroxylaseCYP3A3CYPIIIA3CYPIIIA4Cytochrome P450 3A3Cytochrome P450 HLpCytochrome P450 NF-25Cytochrome P450-PCN1Nifedipine oxidaseQuinine 3-monooxygenaseTaurochenodeoxycholate 6-alpha-hydroxylase>lcl|BSEQ0021936|Cytochrome P450 3A4 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG GLLQPEKPVVLKVESRDGTVSGA>lcl|BSEQ0021937|Cytochrome P450 3A4 (CYP3A4) ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG CTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG CCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTT GACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCT GTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT GTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATA GCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGA AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGC ATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTT CTCTCAATAATCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTGTTT CCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGCCTC GAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAATTCA AAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATTATC TTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTG GCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAAT AAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAAT GAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTT GAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTT CACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAG AAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAAC TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGAGGA CTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTAAGT GGAGCCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintegral component of membranecomponentintracellular membrane-bounded organellefunctionalbendazole monooxygenase activityfunctionaromatase activityfunctioncaffeine oxidase activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxygen bindingfunctionquinine 3-monooxygenase activityfunctionsteroid bindingfunctionsteroid hydroxylase activityfunctiontaurochenodeoxycholate 6alpha-hydroxylase activityfunctiontestosterone 6-beta-hydroxylase activityfunctionvitamin D 24-hydroxylase activityfunctionvitamin D3 25-hydroxylase activityprocessalkaloid catabolic processprocessandrogen metabolic processprocesscalcitriol biosynthetic process from calciolprocessdrug catabolic processprocessdrug metabolic processprocessexogenous drug catabolic processprocessheterocycle metabolic processprocesslipid metabolic processprocessmonoterpenoid metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid catabolic processprocesssteroid metabolic processprocessvitamin D metabolic processprocessxenobiotic metabolic process
载体
运输工具
药物反应
reactions:1
left-element--drugbank-id:DB00191
left-element--name:Phentermine
right-element--drugbank-id:DBMET02227
right-element--name:p-hydroxyphentermine
reactions:1
left-element--drugbank-id:DB00191
left-element--name:Phentermine
right-element--drugbank-id:DBMET02228
right-element--name:N-hydroxyphentermine
reactions:2
left-element--drugbank-id:DBMET02228
left-element--name:N-hydroxyphentermine
right-element--drugbank-id:DBMET02229
right-element--name:Nitrophentermine
效应
不良反应