ID
DB00200|APRD01022||
名称
Hydroxocobalamin
描述
Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.
cas号
13422-51-0
唯一标识码
Q40X8H422O
状态
solid
一般参考文献
Seetharam B, Yammani RR: Cobalamin transport proteins and their cell-surface receptors. Expert Rev Mol Med. 2003 Jun 13;5(18):1-18.


approved,
指示
For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.
药效学
Hydroxocobalamin is a synthetic, injectable form of Vitamin B12. Hydroxocobalamin is actually a precursor of two cofactors or vitamins (Vitamin B12 and Methylcobalamin) which are involved in various biological systems in man. Vitamin B12 is required for the conversion of methylmalonate to succinate. Deficiency of this enzyme could therefore interfere with the production of lipoprotein in myelin sheath tissue and so give rise to neurological lesions. The second cofactor, Methylcobalamin, is necessary for the conversion of homocysteine to methionine which is essential for the metabolism of folic acid. Deficiency of tetrahydrafolate leads to reduced synthesis of thymidylate resulting in reduced synthesis of DNA which is essential for cell maturation. Vitamin B12 is also concerned in the maintenance of sulphydryl groups in reduced form, deficiency leading to decreased amounts of reduced SH content of erythrocytes and liver cells. Overall, vitamin B12 acts as a coenzyme for various metabolic functions, including fat and carbohydrate metabolism and protein synthesis. It is necessary for growth, cell replication, hematopoiesis, and nucleoprotein as well as myelin synthesis. This is largely due to its effects on metabolism of methionine folic acid, and malonic acid.
作用机制
Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of these, methylcobalamin and 5-deoxyadenosyl cobalamin, are primarily used by the body. Methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
毒性
代谢
Primarily hepatic. Cobalamins are absorbed in the ileum and stored in the liver. They continuously undergo enterohepatic recycling via secretion in the bile. Part of a dose is excreted in the urine, most of it in the first 8 hours.
吸收
Readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Vitamin B12 is absorbed in the lower half of the ileum.
半衰期
Approximately 6 days (peak plasma concentration after 8-12 hours from oral administration)
分类
description:This compound belongs to the class of organic compounds known as cobalamin derivatives. These are organic compounds containing a corrin ring, a cobalt atom, an a nucleotide moiety. Cobalamin Derivatives are actually derived from vitamin B12.
direct-parent:Cobalamin derivatives
kingdom:Organic compounds
superclass:Organoheterocyclic compounds
class:Tetrapyrroles and derivatives
subclass:Corrinoids
alternative-parent:Azacyclic compounds
alternative-parent:Benzenoids
alternative-parent:Benzimidazole ribonucleosides and ribonucleotides
alternative-parent:Benzimidazoles
alternative-parent:Carbonyl compounds
alternative-parent:Dialkyl phosphates
alternative-parent:Fatty amides
alternative-parent:Glycosylamines
alternative-parent:Heteroaromatic compounds
alternative-parent:Hydrocarbon derivatives
alternative-parent:Ketimines
alternative-parent:Metallotetrapyrroles
alternative-parent:Monosaccharide phosphates
alternative-parent:N-substituted imidazoles
alternative-parent:Organic cobalt salts
alternative-parent:Organic oxides
alternative-parent:Organic zwitterions
alternative-parent:Organopnictogen compounds
alternative-parent:Oxacyclic compounds
alternative-parent:Pentose phosphates
alternative-parent:Phosphoethanolamines
alternative-parent:Primary alcohols
alternative-parent:Primary carboxylic acid amides
alternative-parent:Propargyl-type 1,3-dipolar organic compounds
alternative-parent:Pyrrolidines
alternative-parent:Pyrrolines
alternative-parent:Secondary alcohols
alternative-parent:Secondary carboxylic acid amides
alternative-parent:Tetrahydrofurans
substituent:1-ribofuranosylbenzimidazole
substituent:Alcohol
substituent:Alkyl phosphate
substituent:Aromatic heteropolycyclic compound
substituent:Azacycle
substituent:Azole
substituent:Benzenoid
substituent:Benzimidazole
substituent:Carbonyl group
substituent:Carboxamide group
substituent:Carboxylic acid derivative
substituent:Cobalamin
substituent:Dialkyl phosphate
substituent:Fatty acyl
substituent:Fatty amide
substituent:Glycosyl compound
substituent:Heteroaromatic compound
substituent:Hydrocarbon derivative
substituent:Imidazole
substituent:Imine
substituent:Ketimine
substituent:Metallotetrapyrrole skeleton
substituent:Monosaccharide
substituent:Monosaccharide phosphate
substituent:N-glycosyl compound
substituent:N-substituted imidazole
substituent:Organic 1,3-dipolar compound
substituent:Organic cobalt salt
substituent:Organic metal salt
substituent:Organic nitrogen compound
substituent:Organic oxide
substituent:Organic oxygen compound
substituent:Organic phosphoric acid derivative
substituent:Organic salt
substituent:Organic transition metal salt
substituent:Organic zwitterion
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound
substituent:Oxacycle
substituent:Pentose monosaccharide
substituent:Pentose phosphate
substituent:Phosphoethanolamine
substituent:Phosphoric acid ester
substituent:Primary alcohol
substituent:Primary carboxylic acid amide
substituent:Propargyl-type 1,3-dipolar organic compound
substituent:Pyrrolidine
substituent:Pyrroline
substituent:Secondary alcohol
substituent:Secondary carboxylic acid amide
substituent:Tetrahydrofuran
消除途径
Each hydroxocobalamin molecule can bind one cyanide ion by substituting it for the hydroxo ligand linked to the trivalent cobalt ion, to form cyanocobalamin, which is then excreted in the urine.
种类
Antianemic Preparations

Antidotes
D000931
Blood and Blood Forming Organs

Corrinoids
D045728
Diet, Food, and Nutrition
D000066888
Drugs that are Mainly Renally Excreted

Food
D005502
Food and Beverages
D019602
Growth Substances
D006133
Hematinics
D006397
Hematologic Agents
D006401
Heterocyclic Compounds, Fused-Ring
D000072471
Micronutrients
D018977
Nutritional Support
D018529
Physiological Phenomena
D010829
Vitamin B Complex
D014803
VITAMIN B12 AND FOLIC ACID

Vitamins
D014815
盐类
DBSALT001895Hydroxocobalamin acetateS535M27N3Q22465-48-1XVRCTDQUXAWPBW-FBTIOKFQSA-K1406.4291405.588195
蛋白质结合
Very high (90%). Cobalamins are extensively bound to two specific plasma proteins called transcobalamin 1 and 2; 70% to transcobalamin 1, 5% to transcobalamin 2.
清除
同义词
language:english; code:inn/usan; name;Hydroxocobalamin
language:english; code:; name;Hydroxocobalamin anhydrous
language:english; code:; name;Hydroxocobalamine
language:english; code:; name;Hydroxocobalaminum anhydrous
language:english; code:; name;Hydroxycobalamin
language:english; code:; name;OH-Cbl
language:english; code:; name;Vitamin B-12b
国际品牌
Alpha-RedisolMerckHydrocobamineNycomed
配送量
产品
name:Aronamin Gold
labeller:OASIS TRADING
ndc-id:
ndc-product-code:72689-0024
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2018-11-20
ended-marketing-on:
dosage-form:Tablet, film coated
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:true
approved:false
country:US
source:FDA NDC
name:Cyanokit
labeller:Serb Sa
ndc-id:
ndc-product-code:
dpd-id:
ema-product-code:EMEA/H/C/000806
ema-ma-number:EU/1/07/420/001
started-marketing-on:2007-11-23
ended-marketing-on:
dosage-form:Injection, powder, for solution
strength:2.5 g
route:Intravenous
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:EU
source:EMA
name:Cyanokit
labeller:Serb Sa
ndc-id:
ndc-product-code:
dpd-id:
ema-product-code:EMEA/H/C/000806
ema-ma-number:EU/1/07/420/002
started-marketing-on:2007-11-23
ended-marketing-on:
dosage-form:Injection, powder, for solution
strength:5 g
route:Intravenous
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:EU
source:EMA
name:Cyanokit
labeller:Dey, L.P.
ndc-id:
ndc-product-code:49502-550
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2007-03-23
ended-marketing-on:2011-09-30
dosage-form:Injection, powder, lyophilized, for solution
strength:2.5 g/100mL
route:Intravenous
fda-application-number:ANDA022041
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cyanokit
labeller:Meridian Medical Technologies , Inc.
ndc-id:
ndc-product-code:11704-270
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2009-08-31
ended-marketing-on:2013-10-31
dosage-form:Injection, powder, lyophilized, for solution
strength:2.5 g/100mL
route:Intravenous
fda-application-number:NDA022041
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cyanokit
labeller:Meridian Medical Technologies, Inc.
ndc-id:
ndc-product-code:11704-370
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2011-10-01
ended-marketing-on:
dosage-form:Injection, powder, lyophilized, for solution
strength:5 g/250mL
route:Intravenous
fda-application-number:NDA022041
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Cyanokit
labeller:Emd Serono, A Division Of Emd Inc., Canada
ndc-id:
ndc-product-code:
dpd-id:02360721
ema-product-code:
ema-ma-number:
started-marketing-on:2011-04-07
ended-marketing-on:2014-09-30
dosage-form:Powder, for solution
strength:2.5 g
route:Intravenous
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Cyanokit
labeller:Serb s.a.
ndc-id:
ndc-product-code:
dpd-id:02375370
ema-product-code:
ema-ma-number:
started-marketing-on:2012-10-19
ended-marketing-on:
dosage-form:Powder, for solution
strength:5 g
route:Intravenous
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:DermaNIC
labeller:Allegis Pharmaceuticals, LLC
ndc-id:
ndc-product-code:28595-500
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-02-03
ended-marketing-on:2016-12-01
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:false
country:US
source:FDA NDC
name:Escavite D
labeller:GM Pharmaceuticals, INC
ndc-id:
ndc-product-code:58809-829
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-03-03
ended-marketing-on:2018-11-01
dosage-form:Tablet, chewable
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:false
country:US
source:FDA NDC
name:Hydro Cobex Inj 1000mcg/ml
labeller:Kripps Pharmacy Ltd.
ndc-id:
ndc-product-code:
dpd-id:00463477
ema-product-code:
ema-ma-number:
started-marketing-on:1979-12-31
ended-marketing-on:
dosage-form:Liquid
strength:
route:Intramuscular
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Hydroxocobalamin
labeller:Remedy Repack
ndc-id:
ndc-product-code:52125-799
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2013-12-11
ended-marketing-on:2015-05-29
dosage-form:Injection, solution
strength:1000 ug/1mL
route:Intramuscular
fda-application-number:ANDA085998
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Hydroxocobalamin
labeller:Actavis Pharma, Inc.
ndc-id:
ndc-product-code:0591-2888
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2010-11-12
ended-marketing-on:
dosage-form:Injection, solution
strength:1000 ug/1mL
route:Intramuscular
fda-application-number:ANDA085998
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Hydroxocobalamin
labeller:A-S Medication Solutions
ndc-id:
ndc-product-code:50090-3548
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2010-11-12
ended-marketing-on:
dosage-form:Injection, solution
strength:1000 ug/1mL
route:Intramuscular
fda-application-number:ANDA085998
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Hydroxocobalamin Inj 1000mcg/ml
labeller:E L Stickley And Co Ltd.
ndc-id:
ndc-product-code:
dpd-id:00230375
ema-product-code:
ema-ma-number:
started-marketing-on:1968-12-31
ended-marketing-on:1996-09-09
dosage-form:Liquid
strength:
route:Intramuscular
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Hydroxy Cobal Inj 1000mcg/ml
labeller:Merit Pharmaceuticals
ndc-id:
ndc-product-code:
dpd-id:00623857
ema-product-code:
ema-ma-number:
started-marketing-on:1984-12-31
ended-marketing-on:2016-08-22
dosage-form:Liquid
strength:
route:Intramuscular
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
混合物
name:Cyanokit
ingredients:Hydroxocobalamin
name:Cyanokit
ingredients:Hydroxocobalamin
name:Cyanokit
ingredients:Hydroxocobalamin
name:Hydroxocobalamin
ingredients:Hydroxocobalamin
name:Cyanokit
ingredients:Hydroxocobalamin
name:DermaNIC
ingredients:Acetylcysteine zinc + Chromium nicotinate + Ferrous cysteine glycinate + Folic acid + Hydroxocobalamin + Inositol nicotinate + Niacin + Nicotinamide
name:Hydroxocobalamin
ingredients:Hydroxocobalamin
name:Aronamin Gold
ingredients:alpha-Tocopherol acetate + Ascorbic acid + Fursultiamine + Hydroxocobalamin + Riboflavin tetrabutyrate
name:Cyanokit
ingredients:Hydroxocobalamin
name:Hydroxocobalamin
ingredients:Hydroxocobalamin
name:Escavite D
ingredients:Ascorbic acid + Beta carotene + Biotin + Cholecalciferol + Cupric oxide + DL-alpha-Tocopherol + Ferrous cysteine glycinate + Folic acid + Hydroxocobalamin + Magnesium oxide + Niacin + Pantothenic acid + Pyridoxine + Riboflavin + Sodium fluoride + Thiamine + Zinc oxide
name:Hydro Cobex Inj 1000mcg/ml
ingredients:Hydroxocobalamin
name:Hydroxocobalamin Inj 1000mcg/ml
ingredients:Hydroxocobalamin
name:Cyanokit
ingredients:Hydroxocobalamin
name:Cyanokit
ingredients:Hydroxocobalamin
name:Hydroxy Cobal Inj 1000mcg/ml
ingredients:Hydroxocobalamin
包装者
name:Abraxis BioScience Inc.
url:http://www.abraxisbio.com
name:C.O. Truxton Inc.
url:
name:Dey Pharma LP
url:http://www.dey.com
name:Letco Medical Inc.
url:http://www.letcomedical.com
name:Martica Enterprises Inc.
url:
name:Meridian Medical Technologies Inc.
url:http://www.meridianmeds.com
name:Merit Pharmaceuticals
url:http://www.meritpharm.com
name:Primedics Laboratories
url:
name:Watson Pharmaceuticals
url:http://www.watson.com
生产者
generic:否; url:; name;Merck and co inc
generic:否; url:; name;Merck sante sas
generic:是; url:; name;Abraxis pharmaceutical products
generic:是; url:; name;Watson laboratories inc
generic:否; url:; name;Bel mar laboratories inc
价格
Hydroxocobalamin 1000 mcg/ml
1.28(单位:USD)
ml
Cyanokit 5 g kit
812.5(单位:USD)
kit
受影响的生物体
Humans and other mammals
剂量
form:Tablet, film coated
route:Oral
strength:
form:
route:
strength:1 MG/ML
form:Injection, powder, for solution
route:Intravenous
strength:2.5 g
form:Injection, powder, for solution
route:Intravenous
strength:5 g
form:Injection, powder, lyophilized, for solution
route:Intravenous
strength:2.5 g/100mL
form:Injection, powder, lyophilized, for solution
route:Intravenous
strength:5 g/250mL
form:Powder, for solution
route:Intravenous
strength:2.5 G
form:Powder, for solution
route:Intravenous
strength:5 G
form:
route:
strength:
form:
route:
strength:1000 UG
form:Tablet
route:Oral
strength:
form:Solution
route:Intramuscular; Intravenous
strength:1 mg/ml
form:Tablet, chewable
route:Oral
strength:
form:Injection, solution
route:
strength:5 mg/2mL
form:Liquid
route:Intramuscular
strength:
form:Injection, solution
route:Intramuscular
strength:1000 ug/1mL
form:Injection, solution
route:Intramuscular
strength:1 MG/1ML
form:Injection, solution
route:Intramuscular
strength:1 MG/2ML
form:Injection, solution
route:Parenteral
strength:1000 µg
form:Injection, solution
route:Intramuscular; Intravenous; Oral
strength:1000 MCG/2.5ML
form:Injection, solution
route:
strength:20 mg/2mL
form:Injection, solution
route:Intramuscular
strength:1 mg
form:Injection, powder, for solution
route:Intravenous
strength:5 MG/2ML
form:
route:
strength:1500 UG
form:
route:
strength:1000 mcg
atc代码
Vitamin B12 (cyanocobalamin and analogues)
VITAMIN B12 AND FOLIC ACID
ANTIANEMIC PREPARATIONS
BLOOD AND BLOOD FORMING ORGANS
Antidotes
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
VARIOUS
Vitamin B12 (cyanocobalamin and analogues)
VITAMIN B12 AND FOLIC ACID
ANTIANEMIC PREPARATIONS
BLOOD AND BLOOD FORMING ORGANS
fda标签
化学品安全技术说明书
//s3-us-west-2.amazonaws.com/drugbank/msds/DB00200.pdf?1265922745
专利
number:5834448
country:United States
approved:1998-11-10
expires:2016-11-14
pediatric-extension:否
食物相互作用
药物相互作用
DB00091
Cyclosporine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00159
Icosapent may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00229
Cefotiam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00244
Mesalazine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00267
Cefmenoxime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00274
Cefmetazole may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00282
Pamidronic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00300
Tenofovir disoproxil may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00328
Indomethacin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00369
Cidofovir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00384
Triamterene may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00430
Cefpiramide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00438
Ceftazidime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00447
Loracarbef may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00456
Cefalotin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00461
Nabumetone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00465
Ketorolac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00469
Tenoxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00482
Celecoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00493
Cefotaxime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00500
Tolmetin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00529
Foscarnet may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00533
Rofecoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00554
Piroxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00563
Methotrexate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00567
Cephalexin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00573
Fenoprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00577
Valaciclovir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00580
Valdecoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00586
Diclofenac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00605
Sulindac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00626
Bacitracin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00681
Amphotericin B may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00689
Cephaloglycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00712
Flurbiprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00718
Adefovir dipivoxil may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00738
Pentamidine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00742
Mannitol may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00749
Etodolac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00784
Mefenamic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00787
Acyclovir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00788
Naproxen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00795
Sulfasalazine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00812
Phenylbutazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00814
Meloxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00821
Carprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00833
Cefaclor may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00861
Diflunisal may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00864
Tacrolimus may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00903
Etacrynic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00923
Ceforanide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00936
Salicylic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00939
Meclofenamic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00945
Acetylsalicylic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00958
Carboplatin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00991
Oxaprozin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00999
Hydrochlorothiazide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01009
Ketoprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01014
Balsalazide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01050
Ibuprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01066
Cefditoren may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01072
Atazanavir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01111
Colistimethate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01112
Cefuroxime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01139
Cefapirin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01140
Cefadroxil may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01150
Cefprozil may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01212
Ceftriaxone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01250
Olsalazine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01283
Lumiracoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01326
Cefamandole may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01327
Cefazolin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01328
Cefonicid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01329
Cefoperazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01330
Cefotetan may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01331
Cefoxitin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01332
Ceftizoxime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01333
Cefradine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01397
Magnesium salicylate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01399
Salsalate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01401
Choline magnesium trisalicylate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01413
Cefepime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01414
Cefacetrile may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01415
Ceftibuten may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01416
Cefpodoxime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01419
Antrafenine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01424
Aminophenazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01435
Antipyrine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01600
Tiaprofenic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01601
Lopinavir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01628
Etoricoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB02247
Hydrolyzed Cephalothin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB03450
Cephalothin Group may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB03585
Oxyphenbutazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04570
Latamoxef may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04743
Nimesulide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04812
Benoxaprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04817
Metamizole may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04828
Zomepirac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04918
Ceftobiprole may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB05095
Cimicoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB06590
Ceftaroline fosamil may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB06725
Lornoxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB06736
Aceclofenac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB06737
Zaltoprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB07402
Azapropazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08439
Parecoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08797
Salicylamide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08940
Kebuzone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08942
Isoxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08951
Indoprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08955
Ibuproxam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08976
Floctafenine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08981
Fenbufen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08984
Etofenamate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08991
Epirizole may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09008
Cefaloridine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09062
Cefminox may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09084
Benzydamine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09213
Dexibuprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09214
Dexketoprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09215
Droxicam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09216
Tolfenamic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09217
Firocoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09218
Clonixin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09285
Morniflumate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09288
Propacetamol may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09295
Talniflumate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09299
Tenofovir alafenamide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB11367
Cefroxadine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB11455
Robenacoxib may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB11466
Tepoxalin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB11518
Flunixin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB11935
Flomoxef may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB12151
Brincidofovir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB12445
Nitroaspirin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB12545
Indobufen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13001
Tinoridine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13167
Alclofenac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13217
Fentiazac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13232
Suxibuzone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13266
Cefatrizine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13286
Bumadizone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13314
Alminoprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13371
Difenpiramide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13407
Nifenazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13432
Lonazolac may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13461
Cefcapene may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13470
Cefodizime may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13481
Tenidap may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13499
Cefsulodin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13504
Cefetamet may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13524
Propyphenazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13527
Proglumetacin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13538
Guacetisal may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13544
Ethenzamide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13612
Carbaspirin calcium may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13629
Mofebutazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13638
Cefbuperazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13649
Proquazone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13657
Benorilate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13667
Cefozopran may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13682
Cefpirome may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13722
Pirprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13778
Cefazedone may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13783
Acemetacin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13821
Ceftezole may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13860
Imidazole salicylate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13868
Adefovir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB14059
SC-236 may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB14060
NS-398 may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB14126
Tenofovir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB14713
Inotersen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01438
Phenazopyridine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB15066
Givosiran may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01356
Lithium cation may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB14507
Lithium citrate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB09212
Loxoprofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00452
Framycetin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01421
Paromomycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04263
Geneticin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04626
Apramycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04808
Neamine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB08437
Puromycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB11512
Dihydrostreptomycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB11520
Hygromycin B may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00007
Leuprolide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00014
Goserelin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00017
Salmon calcitonin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00035
Desmopressin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00041
Aldesleukin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00080
Daptomycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00081
Tositumomab may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00115
Cyanocobalamin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00158
Folic acid may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00165
Pyridoxine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00176
Fluvoxamine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00181
Baclofen may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00182
Amphetamine may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00185
Cevimeline may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00186
Lorazepam may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00190
Carbidopa may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00193
Tramadol may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00196
Fluconazole may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00198
Oseltamivir may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00206
Hydroxocobalamin may decrease the excretion rate of Reserpine which could result in a higher serum level.
DB00208
Hydroxocobalamin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00213
Hydroxocobalamin may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
DB00225
Hydroxocobalamin may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
DB00230
Hydroxocobalamin may decrease the excretion rate of Pregabalin which could result in a higher serum level.
DB00231
Hydroxocobalamin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00235
Hydroxocobalamin may decrease the excretion rate of Milrinone which could result in a higher serum level.
DB00237
Hydroxocobalamin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
DB00243
Hydroxocobalamin may decrease the excretion rate of Ranolazine which could result in a higher serum level.
DB00245
Hydroxocobalamin may decrease the excretion rate of Benzatropine which could result in a higher serum level.
DB00254
Hydroxocobalamin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
DB00262
Hydroxocobalamin may decrease the excretion rate of Carmustine which could result in a higher serum level.
DB00264
Hydroxocobalamin may decrease the excretion rate of Metoprolol which could result in a higher serum level.
DB00270
Hydroxocobalamin may decrease the excretion rate of Isradipine which could result in a higher serum level.
DB00271
Hydroxocobalamin may decrease the excretion rate of Diatrizoate which could result in a higher serum level.
DB00273
Hydroxocobalamin may decrease the excretion rate of Topiramate which could result in a higher serum level.
DB00279
Hydroxocobalamin may decrease the excretion rate of Liothyronine which could result in a higher serum level.
DB00280
Hydroxocobalamin may decrease the excretion rate of Disopyramide which could result in a higher serum level.
DB00284
Hydroxocobalamin may decrease the excretion rate of Acarbose which could result in a higher serum level.
DB00285
Hydroxocobalamin may decrease the excretion rate of Venlafaxine which could result in a higher serum level.
DB00286
Hydroxocobalamin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
DB00289
Hydroxocobalamin may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
DB00290
Hydroxocobalamin may decrease the excretion rate of Bleomycin which could result in a higher serum level.
DB00292
Hydroxocobalamin may decrease the excretion rate of Etomidate which could result in a higher serum level.
DB00294
Hydroxocobalamin may decrease the excretion rate of Etonogestrel which could result in a higher serum level.
DB00296
Hydroxocobalamin may decrease the excretion rate of Ropivacaine which could result in a higher serum level.
DB00303
Hydroxocobalamin may decrease the excretion rate of Ertapenem which could result in a higher serum level.
DB00308
Hydroxocobalamin may decrease the excretion rate of Ibutilide which could result in a higher serum level.
DB00312
Hydroxocobalamin may decrease the excretion rate of Pentobarbital which could result in a higher serum level.
DB00316
Hydroxocobalamin may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
DB00319
Hydroxocobalamin may decrease the excretion rate of Piperacillin which could result in a higher serum level.
DB00322
Hydroxocobalamin may decrease the excretion rate of Floxuridine which could result in a higher serum level.
DB00323
Hydroxocobalamin may decrease the excretion rate of Tolcapone which could result in a higher serum level.
DB00325
Hydroxocobalamin may decrease the excretion rate of Nitroprusside which could result in a higher serum level.
DB00327
Hydroxocobalamin may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
DB00330
Hydroxocobalamin may decrease the excretion rate of Ethambutol which could result in a higher serum level.
DB00331
Hydroxocobalamin may decrease the excretion rate of Metformin which could result in a higher serum level.
DB00333
Hydroxocobalamin may decrease the excretion rate of Methadone which could result in a higher serum level.
DB00339
Hydroxocobalamin may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
DB00341
Hydroxocobalamin may decrease the excretion rate of Cetirizine which could result in a higher serum level.
DB00349
Hydroxocobalamin may decrease the excretion rate of Clobazam which could result in a higher serum level.
DB00351
Hydroxocobalamin may decrease the excretion rate of Megestrol acetate which could result in a higher serum level.
DB00355
Hydroxocobalamin may decrease the excretion rate of Aztreonam which could result in a higher serum level.
DB00356
Hydroxocobalamin may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
DB00359
Hydroxocobalamin may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
DB00363
Hydroxocobalamin may decrease the excretion rate of Clozapine which could result in a higher serum level.
DB00364
Hydroxocobalamin may decrease the excretion rate of Sucralfate which could result in a higher serum level.
DB00372
Hydroxocobalamin may decrease the excretion rate of Thiethylperazine which could result in a higher serum level.
DB00373
Hydroxocobalamin may decrease the excretion rate of Timolol which could result in a higher serum level.
DB00377
Hydroxocobalamin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
DB00380
Hydroxocobalamin may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
DB00398
Hydroxocobalamin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
DB00401
Hydroxocobalamin may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
DB00402
Hydroxocobalamin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
DB00404
Hydroxocobalamin may decrease the excretion rate of Alprazolam which could result in a higher serum level.
DB00412
Hydroxocobalamin may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
DB00413
Hydroxocobalamin may decrease the excretion rate of Pramipexole which could result in a higher serum level.
DB00415
Hydroxocobalamin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
DB00418
Hydroxocobalamin may decrease the excretion rate of Secobarbital which could result in a higher serum level.
DB00422
Hydroxocobalamin may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
DB00432
Hydroxocobalamin may decrease the excretion rate of Trifluridine which could result in a higher serum level.
DB00435
Hydroxocobalamin may decrease the excretion rate of Nitric Oxide which could result in a higher serum level.
DB00437
Hydroxocobalamin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
DB00440
Hydroxocobalamin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
DB00441
Hydroxocobalamin may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
DB00476
Hydroxocobalamin may decrease the excretion rate of Duloxetine which could result in a higher serum level.
DB00477
Hydroxocobalamin may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
DB00480
Hydroxocobalamin may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
DB00490
Hydroxocobalamin may decrease the excretion rate of Buspirone which could result in a higher serum level.
DB00492
Hydroxocobalamin may decrease the excretion rate of Fosinopril which could result in a higher serum level.
DB00499
Hydroxocobalamin may decrease the excretion rate of Flutamide which could result in a higher serum level.
DB00501
Hydroxocobalamin may decrease the excretion rate of Cimetidine which could result in a higher serum level.
DB00502
Hydroxocobalamin may decrease the excretion rate of Haloperidol which could result in a higher serum level.
DB00535
Hydroxocobalamin may decrease the excretion rate of Cefdinir which could result in a higher serum level.
DB00537
Hydroxocobalamin may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
DB00548
Hydroxocobalamin may decrease the excretion rate of Azelaic acid which could result in a higher serum level.
DB00553
Hydroxocobalamin may decrease the excretion rate of Methoxsalen which could result in a higher serum level.
DB00555
Hydroxocobalamin may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
DB00558
Hydroxocobalamin may decrease the excretion rate of Zanamivir which could result in a higher serum level.
DB00569
Hydroxocobalamin may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
DB00571
Hydroxocobalamin may decrease the excretion rate of Propranolol which could result in a higher serum level.
DB00583
Hydroxocobalamin may decrease the excretion rate of Levocarnitine which could result in a higher serum level.
DB00591
Hydroxocobalamin may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level.
DB00597
Hydroxocobalamin may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
DB00598
Hydroxocobalamin may decrease the excretion rate of Labetalol which could result in a higher serum level.
DB00603
Hydroxocobalamin may decrease the excretion rate of Medroxyprogesterone acetate which could result in a higher serum level.
DB00608
Hydroxocobalamin may decrease the excretion rate of Chloroquine which could result in a higher serum level.
DB00612
Hydroxocobalamin may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
DB00624
Hydroxocobalamin may decrease the excretion rate of Testosterone which could result in a higher serum level.
DB00628
Hydroxocobalamin may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
DB00631
Hydroxocobalamin may decrease the excretion rate of Clofarabine which could result in a higher serum level.
DB00633
Hydroxocobalamin may decrease the excretion rate of Dexmedetomidine which could result in a higher serum level.
DB00635
Hydroxocobalamin may decrease the excretion rate of Prednisone which could result in a higher serum level.
DB00651
Hydroxocobalamin may decrease the excretion rate of Dyphylline which could result in a higher serum level.
DB00657
Hydroxocobalamin may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
DB00660
Hydroxocobalamin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
DB00661
Hydroxocobalamin may decrease the excretion rate of Verapamil which could result in a higher serum level.
DB00665
Hydroxocobalamin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
DB00669
Hydroxocobalamin may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
DB00672
Hydroxocobalamin may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
DB00683
Hydroxocobalamin may decrease the excretion rate of Midazolam which could result in a higher serum level.
DB00688
Hydroxocobalamin may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
DB00690
Hydroxocobalamin may decrease the excretion rate of Flurazepam which could result in a higher serum level.
DB00692
Hydroxocobalamin may decrease the excretion rate of Phentolamine which could result in a higher serum level.
DB00698
Hydroxocobalamin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
DB00706
Hydroxocobalamin may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
DB00709
Hydroxocobalamin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
DB00713
Hydroxocobalamin may decrease the excretion rate of Oxacillin which could result in a higher serum level.
DB00716
Hydroxocobalamin may decrease the excretion rate of Nedocromil which could result in a higher serum level.
DB00722
Hydroxocobalamin may decrease the excretion rate of Lisinopril which could result in a higher serum level.
DB00730
Hydroxocobalamin may decrease the excretion rate of Thiabendazole which could result in a higher serum level.
DB00731
Hydroxocobalamin may decrease the excretion rate of Nateglinide which could result in a higher serum level.
DB00733
Hydroxocobalamin may decrease the excretion rate of Pralidoxime which could result in a higher serum level.
DB00743
Hydroxocobalamin may decrease the excretion rate of Gadobenic acid which could result in a higher serum level.
DB00759
Hydroxocobalamin may decrease the excretion rate of Tetracycline which could result in a higher serum level.
DB00760
Hydroxocobalamin may decrease the excretion rate of Meropenem which could result in a higher serum level.
DB00761
Hydroxocobalamin may decrease the excretion rate of Potassium chloride which could result in a higher serum level.
DB00763
Hydroxocobalamin may decrease the excretion rate of Methimazole which could result in a higher serum level.
DB00775
Hydroxocobalamin may decrease the excretion rate of Tirofiban which could result in a higher serum level.
DB00780
Hydroxocobalamin may decrease the excretion rate of Phenelzine which could result in a higher serum level.
DB00782
Hydroxocobalamin may decrease the excretion rate of Propantheline which could result in a higher serum level.
DB00783
Hydroxocobalamin may decrease the excretion rate of Estradiol which could result in a higher serum level.
DB00789
Hydroxocobalamin may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
DB00790
Hydroxocobalamin may decrease the excretion rate of Perindopril which could result in a higher serum level.
DB00800
Hydroxocobalamin may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
DB00804
Hydroxocobalamin may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
DB00806
Hydroxocobalamin may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
DB00811
Hydroxocobalamin may decrease the excretion rate of Ribavirin which could result in a higher serum level.
DB00820
Hydroxocobalamin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
DB00828
Hydroxocobalamin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
DB00829
Hydroxocobalamin may decrease the excretion rate of Diazepam which could result in a higher serum level.
DB00839
Hydroxocobalamin may decrease the excretion rate of Tolazamide which could result in a higher serum level.
DB00841
Hydroxocobalamin may decrease the excretion rate of Dobutamine which could result in a higher serum level.
DB00842
Hydroxocobalamin may decrease the excretion rate of Oxazepam which could result in a higher serum level.
DB00851
Hydroxocobalamin may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
DB00853
Hydroxocobalamin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
DB00863
Hydroxocobalamin may decrease the excretion rate of Ranitidine which could result in a higher serum level.
DB00871
Hydroxocobalamin may decrease the excretion rate of Terbutaline which could result in a higher serum level.
DB00894
Hydroxocobalamin may decrease the excretion rate of Testolactone which could result in a higher serum level.
DB00897
Hydroxocobalamin may decrease the excretion rate of Triazolam which could result in a higher serum level.
DB00900
Hydroxocobalamin may decrease the excretion rate of Didanosine which could result in a higher serum level.
DB00911
Hydroxocobalamin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
DB00915
Hydroxocobalamin may decrease the excretion rate of Amantadine which could result in a higher serum level.
DB00918
Hydroxocobalamin may decrease the excretion rate of Almotriptan which could result in a higher serum level.
DB00928
Hydroxocobalamin may decrease the excretion rate of Azacitidine which could result in a higher serum level.
DB00934
Hydroxocobalamin may decrease the excretion rate of Maprotiline which could result in a higher serum level.
DB00951
Hydroxocobalamin may decrease the excretion rate of Isoniazid which could result in a higher serum level.
DB00953
Hydroxocobalamin may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
DB00960
Hydroxocobalamin may decrease the excretion rate of Pindolol which could result in a higher serum level.
DB00961
Hydroxocobalamin may decrease the excretion rate of Mepivacaine which could result in a higher serum level.
DB00962
Hydroxocobalamin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
DB00968
Hydroxocobalamin may decrease the excretion rate of Methyldopa which could result in a higher serum level.
DB00980
Hydroxocobalamin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
DB00988
Hydroxocobalamin may decrease the excretion rate of Dopamine which could result in a higher serum level.
DB00993
Hydroxocobalamin may decrease the excretion rate of Azathioprine which could result in a higher serum level.
DB00995
Hydroxocobalamin may decrease the excretion rate of Auranofin which could result in a higher serum level.
DB01001
Hydroxocobalamin may decrease the excretion rate of Salbutamol which could result in a higher serum level.
DB01002
Hydroxocobalamin may decrease the excretion rate of Levobupivacaine which could result in a higher serum level.
DB01004
Hydroxocobalamin may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
DB01010
Hydroxocobalamin may decrease the excretion rate of Edrophonium which could result in a higher serum level.
DB01011
Hydroxocobalamin may decrease the excretion rate of Metyrapone which could result in a higher serum level.
DB01015
Hydroxocobalamin may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
DB01018
Hydroxocobalamin may decrease the excretion rate of Guanfacine which could result in a higher serum level.
DB01020
Hydroxocobalamin may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level.
DB01022
Hydroxocobalamin may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
DB01024
Hydroxocobalamin may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
DB01030
Hydroxocobalamin may decrease the excretion rate of Topotecan which could result in a higher serum level.
DB01032
Hydroxocobalamin may decrease the excretion rate of Probenecid which could result in a higher serum level.
DB01036
Hydroxocobalamin may decrease the excretion rate of Tolterodine which could result in a higher serum level.
DB01039
Hydroxocobalamin may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
DB01043
Hydroxocobalamin may decrease the excretion rate of Memantine which could result in a higher serum level.
DB01046
Hydroxocobalamin may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
DB01048
Hydroxocobalamin may decrease the excretion rate of Abacavir which could result in a higher serum level.
DB01060
Hydroxocobalamin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
DB01067
Hydroxocobalamin may decrease the excretion rate of Glipizide which could result in a higher serum level.
DB01068
Hydroxocobalamin may decrease the excretion rate of Clonazepam which could result in a higher serum level.
DB01069
Hydroxocobalamin may decrease the excretion rate of Promethazine which could result in a higher serum level.
DB01093
Hydroxocobalamin may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level.
DB01099
Hydroxocobalamin may decrease the excretion rate of Flucytosine which could result in a higher serum level.
DB01101
Hydroxocobalamin may decrease the excretion rate of Capecitabine which could result in a higher serum level.
DB01105
Hydroxocobalamin may decrease the excretion rate of Sibutramine which could result in a higher serum level.
DB01115
Hydroxocobalamin may decrease the excretion rate of Nifedipine which could result in a higher serum level.
DB01124
Hydroxocobalamin may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
DB01129
Hydroxocobalamin may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
DB01133
Hydroxocobalamin may decrease the excretion rate of Tiludronic acid which could result in a higher serum level.
DB01135
Hydroxocobalamin may decrease the excretion rate of Doxacurium which could result in a higher serum level.
DB01137
Hydroxocobalamin may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
DB01148
Hydroxocobalamin may decrease the excretion rate of Flavoxate which could result in a higher serum level.
DB01149
Hydroxocobalamin may decrease the excretion rate of Nefazodone which could result in a higher serum level.
DB01156
Hydroxocobalamin may decrease the excretion rate of Bupropion which could result in a higher serum level.
DB01157
Hydroxocobalamin may decrease the excretion rate of Trimetrexate which could result in a higher serum level.
DB01166
Hydroxocobalamin may decrease the excretion rate of Cilostazol which could result in a higher serum level.
DB01169
Hydroxocobalamin may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
DB01170
Hydroxocobalamin may decrease the excretion rate of Guanethidine which could result in a higher serum level.
DB01181
Hydroxocobalamin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
DB01183
Hydroxocobalamin may decrease the excretion rate of Naloxone which could result in a higher serum level.
DB01203
Hydroxocobalamin may decrease the excretion rate of Nadolol which could result in a higher serum level.
DB01205
Hydroxocobalamin may decrease the excretion rate of Flumazenil which could result in a higher serum level.
DB01213
Hydroxocobalamin may decrease the excretion rate of Fomepizole which could result in a higher serum level.
DB01215
Hydroxocobalamin may decrease the excretion rate of Estazolam which could result in a higher serum level.
DB01221
Hydroxocobalamin may decrease the excretion rate of Ketamine which could result in a higher serum level.
DB01222
Hydroxocobalamin may decrease the excretion rate of Budesonide which could result in a higher serum level.
DB01224
Hydroxocobalamin may decrease the excretion rate of Quetiapine which could result in a higher serum level.
DB01233
Hydroxocobalamin may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
DB01240
Hydroxocobalamin may decrease the excretion rate of Epoprostenol which could result in a higher serum level.
DB01241
Hydroxocobalamin may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
DB01249
Hydroxocobalamin may decrease the excretion rate of Iodixanol which could result in a higher serum level.
DB01261
Hydroxocobalamin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
DB01267
Hydroxocobalamin may decrease the excretion rate of Paliperidone which could result in a higher serum level.
DB01273
Hydroxocobalamin may decrease the excretion rate of Varenicline which could result in a higher serum level.
DB01274
Hydroxocobalamin may decrease the excretion rate of Arformoterol which could result in a higher serum level.
DB01275
Hydroxocobalamin may decrease the excretion rate of Hydralazine which could result in a higher serum level.
DB01359
Hydroxocobalamin may decrease the excretion rate of Penbutolol which could result in a higher serum level.
DB01367
Hydroxocobalamin may decrease the excretion rate of Rasagiline which could result in a higher serum level.
DB01394
Hydroxocobalamin may decrease the excretion rate of Colchicine which could result in a higher serum level.
DB01409
Hydroxocobalamin may decrease the excretion rate of Tiotropium which could result in a higher serum level.
DB01420
Hydroxocobalamin may decrease the excretion rate of Testosterone propionate which could result in a higher serum level.
DB01427
Hydroxocobalamin may decrease the excretion rate of Amrinone which could result in a higher serum level.
DB01428
Hydroxocobalamin may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
DB01431
Hydroxocobalamin may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
DB01550
Hydroxocobalamin may decrease the excretion rate of Fenproporex which could result in a higher serum level.
DB01558
Hydroxocobalamin may decrease the excretion rate of Bromazepam which could result in a higher serum level.
DB01563
Hydroxocobalamin may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
DB01577
Hydroxocobalamin may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
DB01587
Hydroxocobalamin may decrease the excretion rate of Ketazolam which could result in a higher serum level.
DB01610
Hydroxocobalamin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
DB01638
Hydroxocobalamin may decrease the excretion rate of Sorbitol which could result in a higher serum level.
DB01656
Hydroxocobalamin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
DB01685
Hydroxocobalamin may decrease the excretion rate of Topiroxostat which could result in a higher serum level.
DB04574
Hydroxocobalamin may decrease the excretion rate of Estrone sulfate which could result in a higher serum level.
DB04871
Hydroxocobalamin may decrease the excretion rate of Lorcaserin which could result in a higher serum level.
DB04895
Hydroxocobalamin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
DB04896
Hydroxocobalamin may decrease the excretion rate of Milnacipran which could result in a higher serum level.
DB04920
Hydroxocobalamin may decrease the excretion rate of Clevidipine which could result in a higher serum level.
DB04948
Hydroxocobalamin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
DB04953
Hydroxocobalamin may decrease the excretion rate of Ezogabine which could result in a higher serum level.
DB05018
Hydroxocobalamin may decrease the excretion rate of Migalastat which could result in a higher serum level.
DB05541
Hydroxocobalamin may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
DB05676
Hydroxocobalamin may decrease the excretion rate of Apremilast which could result in a higher serum level.
DB06154
Hydroxocobalamin may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level.
DB06186
Hydroxocobalamin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
DB06196
Hydroxocobalamin may decrease the excretion rate of Icatibant which could result in a higher serum level.
DB06203
Hydroxocobalamin may decrease the excretion rate of Alogliptin which could result in a higher serum level.
DB06209
Hydroxocobalamin may decrease the excretion rate of Prasugrel which could result in a higher serum level.
DB06211
Hydroxocobalamin may decrease the excretion rate of Doripenem which could result in a higher serum level.
DB06228
Hydroxocobalamin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
DB06230
Hydroxocobalamin may decrease the excretion rate of Nalmefene which could result in a higher serum level.
DB06262
Hydroxocobalamin may decrease the excretion rate of Droxidopa which could result in a higher serum level.
DB06282
Hydroxocobalamin may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
DB06335
Hydroxocobalamin may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
DB06402
Hydroxocobalamin may decrease the excretion rate of Telavancin which could result in a higher serum level.
DB06480
Hydroxocobalamin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
DB06623
Hydroxocobalamin may decrease the excretion rate of Flupirtine which could result in a higher serum level.
DB06637
Hydroxocobalamin may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
DB06695
Hydroxocobalamin may decrease the excretion rate of Dabigatran etexilate which could result in a higher serum level.
DB06700
Hydroxocobalamin may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
DB06702
Hydroxocobalamin may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
DB06705
Hydroxocobalamin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
DB06710
Hydroxocobalamin may decrease the excretion rate of Methyltestosterone which could result in a higher serum level.
DB06767
Hydroxocobalamin may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
DB06782
Hydroxocobalamin may decrease the excretion rate of Dimercaprol which could result in a higher serum level.
DB06796
Hydroxocobalamin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
DB06800
Hydroxocobalamin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
DB06809
Hydroxocobalamin may decrease the excretion rate of Plerixafor which could result in a higher serum level.
DB06813
Hydroxocobalamin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
DB06823
Hydroxocobalamin may decrease the excretion rate of Tiopronin which could result in a higher serum level.
DB06824
Hydroxocobalamin may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level.
DB08824
Hydroxocobalamin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
DB08826
Hydroxocobalamin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
DB08840
Hydroxocobalamin may decrease the excretion rate of N-methylnicotinamide which could result in a higher serum level.
DB08872
Hydroxocobalamin may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level.
DB08877
Hydroxocobalamin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
DB08893
Hydroxocobalamin may decrease the excretion rate of Mirabegron which could result in a higher serum level.
DB08894
Hydroxocobalamin may decrease the excretion rate of Peginesatide which could result in a higher serum level.
DB08897
Hydroxocobalamin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
DB08899
Hydroxocobalamin may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
DB08900
Hydroxocobalamin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
DB08904
Hydroxocobalamin may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
DB08905
Hydroxocobalamin may decrease the excretion rate of Formestane which could result in a higher serum level.
DB08909
Hydroxocobalamin may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level.
DB08910
Hydroxocobalamin may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
DB08911
Hydroxocobalamin may decrease the excretion rate of Trametinib which could result in a higher serum level.
DB08918
Hydroxocobalamin may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
DB08932
Hydroxocobalamin may decrease the excretion rate of Macitentan which could result in a higher serum level.
DB08934
Hydroxocobalamin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
DB09027
Hydroxocobalamin may decrease the excretion rate of Ledipasvir which could result in a higher serum level.
DB09050
Hydroxocobalamin may decrease the excretion rate of Ceftolozane which could result in a higher serum level.
DB09066
Hydroxocobalamin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level.
DB09068
Hydroxocobalamin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
DB09071
Hydroxocobalamin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
DB09075
Hydroxocobalamin may decrease the excretion rate of Edoxaban which could result in a higher serum level.
DB09081
Hydroxocobalamin may decrease the excretion rate of Idebenone which could result in a higher serum level.
DB09082
Hydroxocobalamin may decrease the excretion rate of Vilanterol which could result in a higher serum level.
DB09089
Hydroxocobalamin may decrease the excretion rate of Trimebutine which could result in a higher serum level.
DB09091
Hydroxocobalamin may decrease the excretion rate of Tixocortol which could result in a higher serum level.
DB09103
Hydroxocobalamin may decrease the excretion rate of Ancestim which could result in a higher serum level.
DB09104
Hydroxocobalamin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
DB09106
Hydroxocobalamin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
DB09111
Hydroxocobalamin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
DB09118
Hydroxocobalamin may decrease the excretion rate of Stiripentol which could result in a higher serum level.
DB09121
Hydroxocobalamin may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.
DB09123
Hydroxocobalamin may decrease the excretion rate of Dienogest which could result in a higher serum level.
DB09129
Hydroxocobalamin may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
DB09132
Hydroxocobalamin may decrease the excretion rate of Gadoteric acid which could result in a higher serum level.
DB09133
Hydroxocobalamin may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.
DB09134
Hydroxocobalamin may decrease the excretion rate of Ioversol which could result in a higher serum level.
DB09135
Hydroxocobalamin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
DB09136
Hydroxocobalamin may decrease the excretion rate of Isosulfan blue which could result in a higher serum level.
DB09137
Hydroxocobalamin may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
DB09139
Hydroxocobalamin may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level.
DB09148
Hydroxocobalamin may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level.
DB09149
Hydroxocobalamin may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level.
DB09156
Hydroxocobalamin may decrease the excretion rate of Iopromide which could result in a higher serum level.
DB09163
Hydroxocobalamin may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level.
DB09165
Hydroxocobalamin may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level.
DB09185
Hydroxocobalamin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
DB09194
Hydroxocobalamin may decrease the excretion rate of Etoperidone which could result in a higher serum level.
DB09195
Hydroxocobalamin may decrease the excretion rate of Lorpiprazole which could result in a higher serum level.
DB09204
Hydroxocobalamin may decrease the excretion rate of Arotinolol which could result in a higher serum level.
DB09205
Hydroxocobalamin may decrease the excretion rate of Moxisylyte which could result in a higher serum level.
DB09209
Hydroxocobalamin may decrease the excretion rate of Pholcodine which could result in a higher serum level.
DB09210
Hydroxocobalamin may decrease the excretion rate of Piracetam which could result in a higher serum level.
DB09219
Hydroxocobalamin may decrease the excretion rate of Bisoxatin which could result in a higher serum level.
DB09220
Hydroxocobalamin may decrease the excretion rate of Nicorandil which could result in a higher serum level.
DB09223
Hydroxocobalamin may decrease the excretion rate of Blonanserin which could result in a higher serum level.
DB09224
Hydroxocobalamin may decrease the excretion rate of Melperone which could result in a higher serum level.
DB09241
Hydroxocobalamin may decrease the excretion rate of Methylene blue which could result in a higher serum level.
DB09244
Hydroxocobalamin may decrease the excretion rate of Pirlindole which could result in a higher serum level.
DB09245
Hydroxocobalamin may decrease the excretion rate of Toloxatone which could result in a higher serum level.
DB09255
Hydroxocobalamin may decrease the excretion rate of Dextran which could result in a higher serum level.
DB09256
Hydroxocobalamin may decrease the excretion rate of Tegafur which could result in a higher serum level.
DB09257
Hydroxocobalamin may decrease the excretion rate of Gimeracil which could result in a higher serum level.
DB09262
Hydroxocobalamin may decrease the excretion rate of Imidafenacin which could result in a higher serum level.
DB09264
Hydroxocobalamin may decrease the excretion rate of Idarucizumab which could result in a higher serum level.
DB09265
Hydroxocobalamin may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
DB09268
Hydroxocobalamin may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level.
DB09276
Hydroxocobalamin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
DB09277
Hydroxocobalamin may decrease the excretion rate of Choline C 11 which could result in a higher serum level.
DB09281
Hydroxocobalamin may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.
DB09292
Hydroxocobalamin may decrease the excretion rate of Sacubitril which could result in a higher serum level.
DB09301
Hydroxocobalamin may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level.
DB09317
Hydroxocobalamin may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level.
DB09318
Hydroxocobalamin may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level.
DB09320
Hydroxocobalamin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
DB09324
Hydroxocobalamin may decrease the excretion rate of Sulbactam which could result in a higher serum level.
DB09325
Hydroxocobalamin may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
DB09329
Hydroxocobalamin may decrease the excretion rate of Antihemophilic Factor (Recombinant), PEGylated which could result in a higher serum level.
DB09344
Hydroxocobalamin may decrease the excretion rate of Invert sugar which could result in a higher serum level.
DB09357
Hydroxocobalamin may decrease the excretion rate of Dexpanthenol which could result in a higher serum level.
DB09394
Hydroxocobalamin may decrease the excretion rate of Phosphoric acid which could result in a higher serum level.
DB09395
Hydroxocobalamin may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
DB09407
Hydroxocobalamin may decrease the excretion rate of Magnesium chloride which could result in a higher serum level.
DB09418
Hydroxocobalamin may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level.
DB09472
Hydroxocobalamin may decrease the excretion rate of Sodium sulfate which could result in a higher serum level.
DB09477
Hydroxocobalamin may decrease the excretion rate of Enalaprilat which could result in a higher serum level.
DB09481
Hydroxocobalamin may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
DB09488
Hydroxocobalamin may decrease the excretion rate of Acrivastine which could result in a higher serum level.
DB09496
Hydroxocobalamin may decrease the excretion rate of Octinoxate which could result in a higher serum level.
DB09502
Hydroxocobalamin may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
DB09546
Hydroxocobalamin may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level.
DB09570
Hydroxocobalamin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
DB11077
Hydroxocobalamin may decrease the excretion rate of Polyethylene glycol 400 which could result in a higher serum level.
DB11090
Hydroxocobalamin may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
DB11098
Hydroxocobalamin may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
DB11102
Hydroxocobalamin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
DB11114
Hydroxocobalamin may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
DB11127
Hydroxocobalamin may decrease the excretion rate of Selenious acid which could result in a higher serum level.
DB11130
Hydroxocobalamin may decrease the excretion rate of Opium which could result in a higher serum level.
DB11135
Hydroxocobalamin may decrease the excretion rate of Selenium which could result in a higher serum level.
DB11136
Hydroxocobalamin may decrease the excretion rate of Chromium which could result in a higher serum level.
DB11145
Hydroxocobalamin may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
DB11156
Hydroxocobalamin may decrease the excretion rate of Pyrantel which could result in a higher serum level.
DB11164
Hydroxocobalamin may decrease the excretion rate of Bicisate which could result in a higher serum level.
DB11251
Hydroxocobalamin may decrease the excretion rate of Tocopherol which could result in a higher serum level.
DB11278
Hydroxocobalamin may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level.
DB11328
Hydroxocobalamin may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
DB11338
Hydroxocobalamin may decrease the excretion rate of Clove oil which could result in a higher serum level.
DB11358
Hydroxocobalamin may decrease the excretion rate of Evening primrose oil which could result in a higher serum level.
DB11364
Hydroxocobalamin may decrease the excretion rate of Pidotimod which could result in a higher serum level.
DB11560
Hydroxocobalamin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
DB11577
Hydroxocobalamin may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level.
DB11587
Hydroxocobalamin may decrease the excretion rate of Etafedrine which could result in a higher serum level.
DB11598
Hydroxocobalamin may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
DB11642
Hydroxocobalamin may decrease the excretion rate of Pitolisant which could result in a higher serum level.
DB11691
Hydroxocobalamin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
DB11699
Hydroxocobalamin may decrease the excretion rate of Tropisetron which could result in a higher serum level.
DB11817
Hydroxocobalamin may decrease the excretion rate of Baricitinib which could result in a higher serum level.
DB11901
Hydroxocobalamin may decrease the excretion rate of Apalutamide which could result in a higher serum level.
DB11915
Hydroxocobalamin may decrease the excretion rate of Valbenazine which could result in a higher serum level.
DB11943
Hydroxocobalamin may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
DB11989
Hydroxocobalamin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
DB12007
Hydroxocobalamin may decrease the excretion rate of Isoflavone which could result in a higher serum level.
DB12107
Hydroxocobalamin may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
DB12161
Hydroxocobalamin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
DB12278
Hydroxocobalamin may decrease the excretion rate of Propiverine which could result in a higher serum level.
DB12783
Hydroxocobalamin may decrease the excretion rate of Benserazide which could result in a higher serum level.
DB13025
Hydroxocobalamin may decrease the excretion rate of Tiapride which could result in a higher serum level.
DB13139
Hydroxocobalamin may decrease the excretion rate of Levosalbutamol which could result in a higher serum level.
DB13156
Hydroxocobalamin may decrease the excretion rate of Inosine pranobex which could result in a higher serum level.
DB13178
Hydroxocobalamin may decrease the excretion rate of Inositol which could result in a higher serum level.
DB13185
Hydroxocobalamin may decrease the excretion rate of Oxabolone cipionate which could result in a higher serum level.
DB13191
Hydroxocobalamin may decrease the excretion rate of Phosphocreatine which could result in a higher serum level.
DB13269
Hydroxocobalamin may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
DB13293
Hydroxocobalamin may decrease the excretion rate of Ipecac which could result in a higher serum level.
DB13595
Hydroxocobalamin may decrease the excretion rate of Almasilate which could result in a higher serum level.
DB13873
Hydroxocobalamin may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
DB13884
Hydroxocobalamin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
DB13909
Hydroxocobalamin may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
DB13943
Hydroxocobalamin may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
DB13944
Hydroxocobalamin may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.
DB13946
Hydroxocobalamin may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level.
DB13952
Hydroxocobalamin may decrease the excretion rate of Estradiol acetate which could result in a higher serum level.
DB13954
Hydroxocobalamin may decrease the excretion rate of Estradiol cypionate which could result in a higher serum level.
DB13955
Hydroxocobalamin may decrease the excretion rate of Estradiol dienanthate which could result in a higher serum level.
DB13956
Hydroxocobalamin may decrease the excretion rate of Estradiol valerate which could result in a higher serum level.
DB13967
Hydroxocobalamin may decrease the excretion rate of Patent Blue which could result in a higher serum level.
DB14006
Hydroxocobalamin may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
DB14007
Hydroxocobalamin may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
DB14498
Hydroxocobalamin may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
DB14499
Hydroxocobalamin may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
DB14526
Hydroxocobalamin may decrease the excretion rate of Chromic citrate which could result in a higher serum level.
DB14527
Hydroxocobalamin may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
DB14528
Hydroxocobalamin may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
DB14529
Hydroxocobalamin may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.
DB14530
Hydroxocobalamin may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
DB14754
Hydroxocobalamin may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
DB06815
Hydroxocobalamin may decrease the excretion rate of Pyrithione which could result in a higher serum level.
DB11121
Hydroxocobalamin may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
DB11085
Hydroxocobalamin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
DB15593
Hydroxocobalamin may decrease the excretion rate of Golodirsen which could result in a higher serum level.
DB00321
Hydroxocobalamin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
DB00458
Hydroxocobalamin may decrease the excretion rate of Imipramine which could result in a higher serum level.
DB01142
Hydroxocobalamin may decrease the excretion rate of Doxepin which could result in a higher serum level.
DB00318
Hydroxocobalamin may decrease the excretion rate of Codeine which could result in a higher serum level.
DB00454
Hydroxocobalamin may decrease the excretion rate of Meperidine which could result in a higher serum level.
DB00813
Hydroxocobalamin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
DB00879
Hydroxocobalamin may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
DB01151
Hydroxocobalamin may decrease the excretion rate of Desipramine which could result in a higher serum level.
DB01242
Hydroxocobalamin may decrease the excretion rate of Clomipramine which could result in a higher serum level.
DB08996
Hydroxocobalamin may decrease the excretion rate of Dimetacrine which could result in a higher serum level.
DB14506
Hydroxocobalamin may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level.
DB13987
Hydroxocobalamin may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
DB04890
Hydroxocobalamin may decrease the excretion rate of Bepotastine which could result in a higher serum level.
DB00982
Hydroxocobalamin may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
DB04930
Hydroxocobalamin may decrease the excretion rate of Permethrin which could result in a higher serum level.
DB09095
Hydroxocobalamin may decrease the excretion rate of Difluocortolone which could result in a higher serum level.
DB00479
Amikacin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00684
Tobramycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00798
Gentamicin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00955
Netilmicin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00994
Neomycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01082
Streptomycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB01172
Kanamycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB03615
Ribostamycin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB04729
Gentamicin C1a may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB06696
Arbekacin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB12604
Sisomicin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB13540
Isepamicin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00552
Hydroxocobalamin may decrease the excretion rate of Pentostatin which could result in a higher serum level.
DB13145
Hydroxocobalamin may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
DB00314
Hydroxocobalamin may decrease the excretion rate of Capreomycin which could result in a higher serum level.
DB00390
Hydroxocobalamin may decrease the excretion rate of Digoxin which could result in a higher serum level.
DB00512
Hydroxocobalamin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
DB00515
Hydroxocobalamin may decrease the excretion rate of Cisplatin which could result in a higher serum level.
DB00564
Hydroxocobalamin may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
DB00642
Hydroxocobalamin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
DB00682
Hydroxocobalamin may decrease the excretion rate of Warfarin which could result in a higher serum level.
DB00908
Hydroxocobalamin may decrease the excretion rate of Quinidine which could result in a higher serum level.
DB01035
Hydroxocobalamin may decrease the excretion rate of Procainamide which could result in a higher serum level.
DB12615
Hydroxocobalamin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
DB14509
Hydroxocobalamin may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
DB00803
Colistin may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
DB00524
Hydroxocobalamin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
DB00695
Hydroxocobalamin may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
DB00808
Hydroxocobalamin may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
DB00887
Hydroxocobalamin may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
DB00909
Hydroxocobalamin may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
DB08907
Hydroxocobalamin may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
DB09338
Hydroxocobalamin may increase the excretion rate of Mersalyl which could result in a lower serum level and potentially a reduction in efficacy.
DB00214
Torasemide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00232
Methyclothiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00310
Chlorthalidone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00311
Ethoxzolamide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00421
Spironolactone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00436
Bendroflumethiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00562
Benzthiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00594
Amiloride may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00606
Cyclothiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00700
Eplerenone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00703
Methazolamide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00774
Hydroflumethiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00819
Acetazolamide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00872
Conivaptan may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB00880
Chlorothiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01021
Trichlormethiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01119
Diazoxide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01144
Diclofenamide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01324
Polythiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01325
Quinethazone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01395
Drospirenone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01412
Theobromine may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB02925
Piretanide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB04831
Tienilic acid may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB05034
Ularitide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB06212
Tolvaptan may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB06292
Dapagliflozin may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB06370
Indisulam may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB08961
Azosemide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB09015
Canrenoic acid may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB09125
Potassium citrate may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB09235
Efonidipine may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB09401
Isosorbide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB11827
Ertugliflozin may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB12221
Canrenone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB12670
Rolofylline may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB12704
Spiradoline may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB12766
Cicletanine may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13284
Meticrane may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13405
Mefruside may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13430
Mebutizide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13532
Cyclopenthiazide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13617
Clorexolone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13663
Clofenamide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13708
Fenquizone may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13792
Clopamide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13801
Muzolimine may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13803
Xipamide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB13989
Epitizide may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB14018
Bromotheophylline may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB14500
Potassium may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
DB01345
Hydroxocobalamin may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
序列
实验性质
外部标识符
resource:Drugs Product Database (DPD)
identifier:4971
resource:ChEBI
identifier:27786
resource:PubChem Compound
identifier:70678542
resource:PubChem Substance
identifier:46505751
resource:KEGG Compound
identifier:C08230
resource:KEGG Drug
identifier:D01027
resource:ChemSpider
identifier:21403074
resource:PharmGKB
identifier:PA164768689
resource:Therapeutic Targets Database
identifier:DAP001336
resource:Wikipedia
identifier:Hydroxocobalamin
resource:ChEMBL
identifier:CHEMBL2103737
resource:RxCUI
identifier:5514
外部链接
RxList
http://www.rxlist.com/cgi/generic/cyanokit.htm
Drugs.com
http://www.drugs.com/cdi/hydroxocobalamin.html
路径
目标
id:BE0000734
name:Methionine synthase
organism:Humans
action:cofactor
Kolhouse JF, Utley C, Stabler SP, Allen RH: Mechanism of conversion of human apo- to holomethionine synthase by various forms of cobalamin. J Biol Chem. 1991 Dec 5;266(34):23010-5.
Ogier de Baulny H, Gerard M, Saudubray JM, Zittoun J: Remethylation defects: guidelines for clinical diagnosis and treatment. Eur J Pediatr. 1998 Apr;157 Suppl 2:S77-83.
Tkachuck RD, Weinstein PP, Mueller JF: Metabolic fate of cyanocobalamin taken up by Spirometra mansonoides spargana. J Parasitol. 1977 Aug;63(4):694-700.
Quadros EV, Jacobsen DW: The dynamics of cobalamin utilization in L-1210 mouse leukemia cells: a model of cellular cobalamin metabolism. Biochim Biophys Acta. 1995 Jun 9;1244(2-3):395-403.
Rosenblatt DS, Thomas IT, Watkins D, Cooper BA, Erbe RW: Vitamin B12 responsive homocystinuria and megaloblastic anemia: heterogeneity in methylcobalamin deficiency. Am J Med Genet. 1987 Feb;26(2):377-83.
known-action:yes
name:Methionine synthase
general-function:Zinc ion binding
specific-function:Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
gene-name:MTR
locus:1q43
cellular-location:Cytoplasm
transmembrane-regions:
signal-regions:
theoretical-pi:5.27
molecular-weight:140525.91
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:7468GenAtlasMTRGenBank Gene DatabaseU71285GenBank Protein Database1923221UniProtKBQ99707UniProt AccessionMETH_HUMAN
synonyms:2.1.1.135-methyltetrahydrofolate--homocysteine methyltransferaseMSVitamin-B12 dependent methionine synthase
amino-acid-sequence:>lcl|BSEQ0001464|Methionine synthase MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHA RPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC SAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQA KGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQT GEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDET PSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGL EPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDG MLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD FLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNI LTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLY HAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKV IQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVG DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATV KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM IFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN LKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQV FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTL ISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYY CLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEE LHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTG IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPIL GYDTD
gene-sequence:>lcl|BSEQ0010518|Methionine synthase (MTR) ATGTCACCCGCGCTCCAAGACCTGTCGCAACCCGAAGGTCTGAAGAAAACCCTGCGGGAT GAGATCAATGCCATTCTGCAGAAGAGGATTATGGTGCTGGATGGAGGGATGGGGACCATG ATCCAGCGGGAGAAGCTAAACGAAGAACACTTCCGAGGTCAGGAATTTAAAGATCATGCC AGGCCGCTGAAAGGCAACAATGACATTTTAAGTATAACTCAGCCTGATGTCATTTACCAA ATCCATAAGGAATACTTGCTGGCTGGGGCAGATATCATTGAAACAAATACTTTTAGCAGC ACTAGTATTGCCCAAGCTGACTATGGCCTTGAACACTTGGCCTACCGGATGAACATGTGC TCTGCAGGAGTGGCCAGAAAAGCTGCCGAGGAGGTAACTCTCCAGACAGGAATTAAGAGG TTTGTGGCAGGGGCTCTGGGTCCGACTAATAAGACACTCTCTGTGTCCCCATCTGTGGAA AGGCCGGATTATAGGAACATCACATTTGATGAGCTTGTTGAAGCATACCAAGAGCAGGCC AAAGGACTTCTGGATGGCGGGGTTGATATCTTACTCATTGAAACTATTTTTGATACTGCC AATGCCAAGGCAGCCTTGTTTGCACTCCAAAATCTTTTTGAGGAGAAATATGCTCCCCGG CCTATCTTTATTTCAGGGACGATCGTTGATAAAAGTGGGCGGACTCTTTCCGGACAGACA GGAGAGGGATTTGTCATCAGCGTGTCTCATGGAGAACCACTCTGCATTGGATTAAATTGT GCTTTGGGTGCAGCTGAAATGAGACCTTTTATTGAAATAATTGGAAAATGTACAACAGCC TATGTCCTCTGTTATCCCAATGCAGGTCTTCCCAACACCTTTGGTGACTATGATGAAACG CCTTCTATGATGGCCAAGCACCTAAAGGATTTTGCTATGGATGGCTTGGTCAATATAGTT GGAGGATGCTGTGGGTCAACACCAGATCATATCAGGGAAATTGCTGAAGCTGTGAAAAAT TGTAAGCCTAGAGTTCCACCTGCCACTGCTTTTGAAGGACATATGTTACTGTCTGGTCTA GAGCCCTTCAGGATTGGACCGTACACCAACTTTGTTAACATTGGAGAGCGCTGTAATGTT GCAGGATCAAGGAAGTTTGCTAAACTCATCATGGCAGGAAACTATGAAGAAGCCTTGTGT GTTGCCAAAGTGCAGGTGGAAATGGGAGCCCAGGTGTTGGATGTCAACATGGATGATGGC ATGCTAGATGGTCCAAGTGCAATGACCAGATTTTGCAACTTAATTGCTTCCGAGCCAGAC ATCGCAAAGGTACCTTTGTGCATCGACTCCTCCAATTTTGCTGTGATTGAAGCTGGGTTA AAGTGCTGCCAAGGGAAGTGCATTGTCAATAGCATTAGTCTGAAGGAAGGAGAGGACGAC TTCTTGGAGAAGGCCAGGAAGATTAAAAAGTATGGAGCTGCTATGGTGGTCATGGCTTTT GATGAAGAAGGACAGGCAACAGAAACAGACACAAAAATCAGAGTGTGCACCCGGGCCTAC CATCTGCTTGTGAAAAAACTGGGCTTTAATCCAAATGACATTATTTTTGACCCTAATATC CTAACCATTGGGACTGGAATGGAGGAACACAACTTGTATGCCATTAATTTTATCCATGCA ACAAAAGTCATTAAAGAAACATTACCTGGAGCCAGAATAAGTGGAGGTCTTTCCAACTTG TCCTTCTCCTTCCGAGGAATGGAAGCCATTCGAGAAGCAATGCATGGGGTTTTCCTTTAC CATGCAATCAAGTCTGGCATGGACATGGGGATAGTGAATGCTGGAAACCTCCCTGTGTAT GATGATATCCATAAGGAACTTCTGCAGCTCTGTGAAGATCTCATCTGGAATAAAGACCCT GAGGCCACTGAGAAGCTCTTACGTTATGCCCAGACTCAAGGCACAGGAGGGAAGAAAGTC ATTCAGACTGATGAGTGGAGAAATGGCCCTGTCGAAGAACGCCTTGAGTATGCCCTTGTG AAGGGCATTGAAAAACATATTATTGAGGATACTGAGGAAGCCAGGTTAAACCAAAAAAAA TATCCCCGACCTCTCAATATAATTGAAGGACCCCTGATGAATGGAATGAAAATTGTTGGT GATCTTTTTGGAGCTGGAAAAATGTTTCTACCTCAGGTTATAAAGTCAGCCCGGGTTATG AAGAAGGCTGTTGGCCACCTTATCCCTTTCATGGAAAAAGAAAGAGAAGAAACCAGAGTG CTTAACGGCACAGTAGAAGAAGAGGACCCTTACCAGGGCACCATCGTGCTGGCCACTGTT AAAGGCGACGTGCACGACATAGGCAAGAACATAGTTGGAGTAGTCCTTGGCTGCAATAAT TTCCGAGTTATTGATTTAGGAGTCATGACTCCATGTGATAAGATACTGAAAGCTGCTCTT GACCACAAAGCAGATATAATTGGCCTGTCAGGACTCATCACTCCTTCCCTGGATGAAATG ATTTTTGTTGCCAAGGAAATGGAGAGATTAGCTATAAGGATTCCATTGTTGATTGGAGGA GCAACCACTTCAAAAACCCACACAGCAGTTAAAATAGCTCCGAGATACAGTGCACCTGTA ATCCATGTCCTGGACGCGTCCAAGAGTGTGGTGGTGTGTTCCCAGCTGTTAGATGAAAAT CTAAAGGATGAATACTTTGAGGAAATCATGGAAGAATATGAAGATATTAGACAGGACCAT TATGAGTCTCTCAAGGAGAGGAGATACTTACCCTTAAGTCAAGCCAGAAAAAGTGGTTTC CAAATGGATTGGCTGTCTGAACCTCACCCAGTGAAGCCCACGTTTATTGGGACCCAGGTC TTTGAAGACTATGACCTGCAGAAGCTGGTGGACTACATTGACTGGAAGCCTTTCTTTGAT GTCTGGCAGCTCCGGGGCAAGTACCCGAATCGAGGCTTTCCCAAGATATTTAACGACAAA ACAGTAGGTGGAGAGGCCAGGAAGGTCTACGATGATGCCCACAATATGCTGAACACACTG ATTAGTCAAAAGAAACTCCGGGCCCGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGTATC CAAGACGACATTCACCTGTACGCAGAGGCTGCTGTGCCCCAGGCTGCAGAGCCCATAGCC ACCTTCTATGGGTTAAGGCAACAGGCTGAGAAGGACTCTGCCAGCACGGAGCCATACTAC TGCCTCTCAGACTTCATCGCTCCCTTGCATTCTGGCATCCGTGACTACCTGGGCCTGTTT GCCGTTGCCTGCTTTGGGGTAGAAGAGCTGAGCAAGGCCTATGAGGATGATGGTGACGAC TACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTGGCAGAGGCCTTTGCAGAAGAG CTCCATGAAAGAGTTCGCCGAGAACTGTGGGCCTACTGTGGCAGTGAGCAGCTGGACGTC GCAGACCTGCGCAGGCTGCGGTACAAGGGCATCCGCCCGGCTCCTGGCTACCCCAGCCAG CCCGACCACACCGAGAAGCTCACCATGTGGAGACTCGCAGACATCGAGCAGTCTACAGGC ATTAGGTTAACAGAATCATTAGCAATGGCACCTGCTTCAGCAGTCTCAGGCCTCTACTTC TCCAATTTGAAGTCCAAATATTTTGCTGTGGGGAAGATTTCCAAGGATCAGGTTGAGGAT TATGCATTGAGGAAGAACATATCTGTGGCTGAGGTTGAGAAATGGCTTGGACCCATTTTG GGATATGATACAGACTAA
pfams:PF00809Pterin_bindPF02310B12-bindingPF02607B12-binding_2PF02965Met_synt_B12PF02574S-methyl_trans
go-classifiers:componentcytoplasmcomponentcytosolfunctioncobalamin bindingfunctionmethionine synthase activityfunctionS-adenosylmethionine-homocysteine S-methyltransferase activityfunctionzinc ion bindingprocessaxon regenerationprocesscellular nitrogen compound metabolic processprocesscellular response to nitric oxideprocesscobalamin metabolic processprocessmethionine biosynthetic processprocessmethylationprocessnervous system developmentprocesspteridine-containing compound metabolic processprocessresponse to axon injuryprocesssmall molecule metabolic processprocesssulfur amino acid metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic processprocessxenobiotic metabolic process
id:BE0000777
name:Methylmalonyl-CoA mutase, mitochondrial
organism:Humans
action:cofactor
Willard HF, Rosenberg LE: Inborn errors of cobalamin metabolism: effect of cobalamin supplementation in culture on methylmalonyl CoA mutase activity in normal and mutant human fibroblasts. Biochem Genet. 1979 Feb;17(1-2):57-75.
Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT: Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry. 2002 Apr 23;41(16):5193-201.
Mayatepek E, Hoffmann GF, Baumgartner R, Schulze A, Jakobs C, Trefz FK, Bremer HJ: Atypical vitamin B12-unresponsive methylmalonic aciduria in sibship with severe progressive encephalomyelopathy: a new genetic disease? Eur J Pediatr. 1996 May;155(5):398-403.
Tkachuck RD, Weinstein PP, Mueller JF: Metabolic fate of cyanocobalamin taken up by Spirometra mansonoides spargana. J Parasitol. 1977 Aug;63(4):694-700.
Quadros EV, Jacobsen DW: The dynamics of cobalamin utilization in L-1210 mouse leukemia cells: a model of cellular cobalamin metabolism. Biochim Biophys Acta. 1995 Jun 9;1244(2-3):395-403.
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
known-action:yes
name:Methylmalonyl-CoA mutase, mitochondrial
general-function:Modified amino acid binding
specific-function:Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.
gene-name:MUT
locus:6p21
cellular-location:Mitochondrion matrix
transmembrane-regions:
signal-regions:
theoretical-pi:6.92
molecular-weight:83133.755
chromosome-location:6
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:7526GenAtlasMUTGenBank Gene DatabaseM65131GenBank Protein Database187452UniProtKBP22033UniProt AccessionMUTA_HUMAN
synonyms:5.4.99.2MCMMethylmalonyl-CoA isomerase
amino-acid-sequence:>lcl|BSEQ0016203|Methylmalonyl-CoA mutase, mitochondrial MLRAKNQLFLLSPHYLRQVKESSGSRLIQQRLLHQQQPLHPEWAALAKKQLKGKNPEDLI WHTPEGISIKPLYSKRDTMDLPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESN KFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLE KMSVSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMK IIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYTLADGLEYSRTGLQAGLTIDE FAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTE QDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPK VADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARID SGSEVIVGVNKYQLEKEDAVEVLAIDNTSVRNRQIEKLKKIKSSRDQALAERCLAALTEC AASGDGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSA IKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQ AVDADVHAVGISTLAAGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSN VFGPGTRIPKAAVQVLDDIEKCLEKKQQSV
gene-sequence:>lcl|BSEQ0016204|Methylmalonyl-CoA mutase, mitochondrial (MUT) ATGTTAAGAGCTAAGAATCAGCTTTTTTTACTTTCACCTCATTACCTGAGGCAGGTAAAA GAATCATCAGGCTCCAGGCTCATACAGCAACGACTTCTACACCAGCAACAGCCCCTTCAC CCAGAATGGGCTGCCCTGGCTAAAAAGCAGCTGAAAGGCAAAAACCCAGAAGACCTAATA TGGCACACCCCGGAAGGGATCTCTATAAAACCCTTGTATTCCAAGAGAGATACTATGGAC TTACCTGAAGAACTTCCAGGAGTGAAGCCATTCACACGTGGACCATATCCTACCATGTAT ACCTTTAGGCCCTGGACCATCCGCCAGTATGCTGGTTTTAGTACTGTGGAAGAAAGCAAT AAGTTCTATAAGGACAACATTAAGGCTGGTCAGCAGGGATTATCAGTTGCCTTTGATCTG GCGACACATCGTGGCTATGATTCAGACAACCCTCGAGTTCGTGGTGATGTTGGAATGGCT GGAGTTGCTATTGACACTGTGGAAGATACCAAAATTCTTTTTGATGGAATTCCTTTAGAA AAAATGTCAGTTTCCATGACTATGAATGGAGCAGTTATTCCAGTTCTTGCAAATTTTATA GTAACTGGAGAAGAACAAGGTGTACCTAAAGAGAAGCTTACTGGTACCATCCAAAATGAT ATACTAAAGGAATTTATGGTTCGAAATACATACATTTTTCCTCCAGAACCATCCATGAAA ATTATTGCTGACATATTTGAATATACAGCAAAGCACATGCCAAAATTTAATTCAATTTCA ATTAGTGGATACCATATGCAGGAAGCAGGGGCTGATGCCATTCTGGAGCTGGCCTATACT TTAGCAGATGGATTGGAGTACTCTAGAACTGGACTCCAGGCTGGCCTGACAATTGATGAA TTTGCACCAAGGTTGTCTTTCTTCTGGGGAATTGGAATGAATTTCTATATGGAAATAGCA AAGATGAGAGCTGGTAGAAGACTCTGGGCTCACTTAATAGAGAAAATGTTTCAGCCTAAA AACTCAAAATCTCTTCTTCTAAGAGCACACTGTCAGACATCTGGATGGTCACTTACTGAG CAGGATCCCTACAATAATATTGTCCGTACTGCAATAGAAGCAATGGCAGCAGTATTTGGA GGGACTCAGTCTTTGCACACAAATTCTTTTGATGAAGCTTTGGGTTTGCCAACTGTGAAA AGTGCTCGAATTGCCAGGAACACACAAATCATCATTCAAGAAGAATCTGGGATTCCCAAA GTGGCTGATCCTTGGGGAGGTTCTTACATGATGGAATGTCTCACAAATGATGTTTATGAT GCTGCTTTAAAGCTCATTAATGAAATTGAAGAAATGGGTGGAATGGCCAAAGCTGTAGCT GAGGGAATACCTAAACTTCGAATTGAAGAATGTGCTGCCCGAAGACAAGCTAGAATAGAT TCTGGTTCTGAAGTAATTGTTGGAGTAAATAAGTACCAGTTGGAAAAAGAAGACGCTGTA GAAGTTCTGGCAATTGATAATACTTCAGTGCGAAACAGGCAGATTGAAAAACTTAAGAAG ATCAAATCCAGCAGGGATCAAGCTTTGGCTGAACGTTGTCTTGCTGCACTAACCGAATGT GCTGCTAGCGGAGATGGAAATATCCTGGCTCTTGCAGTGGATGCATCTCGGGCAAGATGT ACAGTGGGAGAAATCACAGATGCCCTGAAAAAGGTATTTGGTGAACATAAAGCGAATGAT CGAATGGTGAGTGGAGCATATCGCCAGGAATTTGGAGAAAGTAAAGAGATAACATCTGCT ATCAAGAGGGTTCATAAATTCATGGAACGTGAAGGTCGCAGACCTCGTCTTCTTGTAGCA AAAATGGGACAAGATGGCCATGACAGAGGAGCAAAAGTTATTGCTACAGGATTTGCTGAT CTTGGTTTTGATGTGGACATAGGCCCTCTTTTCCAGACTCCTCGTGAAGTGGCCCAGCAG GCTGTGGATGCGGATGTGCATGCTGTGGGCATAAGCACCCTCGCTGCTGGTCATAAAACC CTAGTTCCTGAACTCATCAAAGAACTTAACTCCCTTGGACGGCCAGATATTCTTGTCATG TGTGGAGGGGTGATACCACCTCAGGATTATGAATTTCTGTTTGAAGTTGGTGTTTCCAAT GTATTTGGTCCTGGGACTCGAATTCCAAAGGCTGCCGTTCAGGTGCTTGATGATATTGAG AAGTGTTTGGAAAAGAAGCAGCAATCTGTATAA
pfams:PF02310B12-bindingPF01642MM_CoA_mutase
go-classifiers:componentmitochondrial matrixcomponentmitochondrionfunctioncobalamin bindingfunctionmetal ion bindingfunctionmethylmalonyl-CoA mutase activityfunctionmodified amino acid bindingprocesscellular lipid metabolic processprocesscobalamin metabolic processprocessfatty acid beta-oxidationprocesshomocysteine metabolic processprocesspost-embryonic developmentprocessshort-chain fatty acid catabolic processprocesssmall molecule metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic process
id:BE0000320
name:Methylmalonic aciduria type A protein, mitochondrial
organism:Humans
action:other/unknown
Manoli I, Sloan JL, Venditti CP: Isolated Methylmalonic Acidemia .
known-action:unknown
name:Methylmalonic aciduria type A protein, mitochondrial
general-function:Hydrolase activity
specific-function:Probable GTPase. May function as chaperone. May be involved in the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis.
gene-name:MMAA
locus:4q31.22
cellular-location:Mitochondrion
transmembrane-regions:
signal-regions:
theoretical-pi:9.83
molecular-weight:46537.865
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:18871GenAtlasMMAAGenBank Gene DatabaseAF524846GenBank Protein Database26006421UniProtKBQ8IVH4UniProt AccessionMMAA_HUMAN
synonyms:3.6.-.-
amino-acid-sequence:>lcl|BSEQ0010245|Methylmalonic aciduria type A protein, mitochondrial MPMLLPHPHQHFLKGLLRAPFRCYHFIFHSSTHLGSGIPCAQPFNSLGLHCTKWMLLSDG LKRKLCVQTTLKDHTEGLSDKEQRFVDKLYTGLIQGQRACLAEAITLVESTHSRKKELAQ VLLQKVLLYHREQEQSNKGKPLAFRVGLSGPPGAGKSTFIEYFGKMLTERGHKLSVLAVD PSSCTSGGSLLGDKTRMTELSRDMNAYIRPSPTRGTLGGVTRTTNEAILLCEGAGYDIIL IETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVAVTKSDGDLIVPAR RIQAEYVSALKLLRKRSQVWKPKVIRISARSGEGISEMWDKMKDFQDLMLASGELTAKRR KQQKVWMWNLIQESVLEHFRTHPTVREQIPLLEQKVLIGALSPGLAADFLLKAFKSRD
gene-sequence:>lcl|BSEQ0010246|Methylmalonic aciduria type A protein, mitochondrial (MMAA) ATGCCCATGCTGCTACCACATCCTCACCAGCATTTCCTAAAAGGCCTTTTAAGAGCACCT TTCCGATGTTACCACTTCATCTTTCACTCAAGTACTCATCTCGGATCAGGAATCCCATGT GCTCAGCCGTTTAATTCTCTTGGACTCCATTGTACAAAGTGGATGCTGCTGTCAGATGGC TTAAAGAGAAAATTATGTGTACAAACAACCTTAAAGGACCACACAGAAGGACTTTCTGAT AAAGAGCAAAGATTTGTGGATAAACTTTATACTGGTTTAATCCAAGGGCAAAGGGCCTGT TTAGCAGAGGCCATAACTCTTGTAGAATCAACTCACAGCAGGAAAAAGGAGTTAGCCCAG GTGCTTCTTCAGAAAGTATTACTTTACCACAGAGAACAAGAACAATCAAATAAAGGAAAA CCACTAGCATTTCGAGTAGGATTGTCTGGGCCCCCTGGTGCTGGAAAATCAACATTTATA GAATATTTTGGAAAAATGCTTACTGAGAGAGGGCACAAATTATCTGTGCTAGCTGTGGAC CCTTCTTCTTGTACTAGTGGTGGATCACTCTTAGGTGATAAAACCCGAATGACTGAGTTA TCAAGAGATATGAATGCATACATCAGGCCATCTCCTACTAGAGGAACTTTAGGAGGCGTG ACAAGGACCACAAATGAAGCTATTCTGTTGTGTGAAGGAGCGGGATATGACATAATTCTT ATTGAAACCGTTGGTGTGGGTCAGTCGGAGTTTGCTGTTGCTGACATGGTTGACATGTTT GTTTTACTACTGCCACCAGCAGGAGGAGATGAGCTGCAGGGTATCAAAAGGGGTATAATC GAGATGGCAGATCTGGTAGCTGTAACTAAATCTGATGGAGACTTGATTGTGCCAGCTCGA AGGATACAAGCGGAATATGTGAGTGCACTGAAATTACTCCGCAAACGTTCACAAGTCTGG AAACCAAAGGTAATTCGTATTTCTGCCCGAAGTGGAGAGGGGATCTCTGAAATGTGGGAT AAAATGAAAGATTTCCAGGACCTAATGCTTGCCAGTGGGGAGCTGACTGCCAAACGACGG AAGCAACAGAAAGTTTGGATGTGGAATCTCATTCAGGAAAGTGTGTTAGAGCATTTCAGG ACCCACCCCACAGTCCGGGAACAGATTCCACTTCTGGAACAAAAGGTTCTCATTGGGGCC CTGTCCCCAGGACTAGCAGCAGACTTCTTGTTAAAAGCTTTTAAAAGCAGAGACTAA
pfams:PF03308ArgK
go-classifiers:componentmitochondrial matrixfunctionGTP bindingfunctionhydrolase activityprocesscellular lipid metabolic processprocesscobalamin biosynthetic processprocesscobalamin metabolic processprocessfatty acid beta-oxidationprocessshort-chain fatty acid catabolic processprocesssmall molecule metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic process
id:BE0000238
name:Transcobalamin-1
organism:Humans
action:other
MacDonald CM, Farquharson J, Bessent RG, Adams JF: The forms of vitamin B12 on the transcobalamins. Clin Sci Mol Med. 1977 Feb;52(2):215-8.
Rothenberg SP, Marcoullis GP, Schwarz S, Lader E: Measurement of cyanocobalamin in serum by a specific radioimmunoassay. J Lab Clin Med. 1984 Jun;103(6):959-72.
known-action:unknown
name:Transcobalamin-1
general-function:Cobalamin binding
specific-function:Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
gene-name:TCN1
locus:11q11-q12
cellular-location:Secreted
transmembrane-regions:
signal-regions:1-23
theoretical-pi:4.68
molecular-weight:48206.32
chromosome-location:11
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:11652GenAtlasTCN1GenBank Gene DatabaseJ05068GenBank Protein Database307479UniProtKBP20061UniProt AccessionTCO1_HUMAN
synonyms:HaptocorrinHCProtein RTC ITC-1TC1TCITranscobalamin I
amino-acid-sequence:>lcl|BSEQ0016043|Transcobalamin-1 MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLS LKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLID KLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFG SQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGN TFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFL DINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLS VMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVV RNGENLEVRWSKY
gene-sequence:>lcl|BSEQ0016044|Transcobalamin-1 (TCN1) ATGAGACAGTCACACCAGCTGCCCCTAGTGGGGCTCTTACTGTTTTCTTTTATTCCAAGC CAACTATGCGAGATTTGTGAGGTAAGTGAAGAAAACTACATCCGCCTAAAACCTCTGTTG AATACAATGATCCAGTCAAACTATAACAGGGGAACCAGCGCTGTCAATGTTGTGTTGTCC CTCAAACTTGTTGGAATCCAGATCCAAACCCTGATGCAAAAGATGATCCAACAAATCAAA TACAATGTGAAAAGCAGATTGTCAGATGTAAGCTCGGGAGAGCTTGCCTTGATTATACTG GCTTTGGGAGTATGTCGTAACGCTGAGGAAAACTTAATATATGATTACCACCTGATCGAC AAGCTAGAAAATAAATTCCAAGCAGAAATTGAAAATATGGAAGCACACAATGGCACTCCC CTGACTAACTACTACCAGCTCAGCCTGGACGTTTTGGCCTTGTGTCTGTTCAATGGGAAC TACTCAACCGCCGAAGTTGTCAACCACTTCACTCCTGAAAATAAAAACTATTATTTTGGT AGCCAGTTCTCAGTAGATACTGGTGCAATGGCTGTCCTGGCTCTGACCTGTGTGAAGAAG AGTCTAATAAATGGGCAGATCAAAGCAGATGAAGGCAGTTTAAAGAACATCAGTATTTAT ACAAAGTCACTGGTAGAAAAGATTCTGTCTGAGAAAAAAGAAAATGGTCTCATTGGAAAC ACATTTAGCACAGGAGAAGCCATGCAGGCCCTCTTTGTATCATCAGACTATTATAATGAA AATGACTGGAATTGCCAACAAACTCTGAATACAGTGCTCACGGAAATTTCTCAAGGAGCA TTCAGCAATCCAAACGCTGCAGCCCAGGTCTTACCTGCCCTGATGGGAAAGACCTTCTTG GATATTAACAAAGACTCTTCTTGCGTCTCTGCTTCAGGTAACTTCAACATCTCCGCTGAT GAGCCTATAACTGTGACACCTCCTGACTCACAATCATATATCTCCGTCAATTACTCTGTG AGAATCAATGAAACATATTTCACCAATGTCACTGTGCTAAATGGTTCTGTCTTCCTCAGT GTGATGGAGAAAGCCCAGAAAATGAATGATACTATATTTGGTTTCACAATGGAGGAGCGC TCATGGGGGCCCTATATCACCTGTATTCAGGGCCTATGTGCCAACAATAATGACAGAACC TACTGGGAACTTCTGAGTGGAGGCGAACCACTGAGCCAAGGAGCTGGTAGTTACGTTGTC CGCAATGGAGAAAACTTGGAGGTTCGCTGGAGCAAATACTAA
pfams:PF01122Cobalamin_bindPF14478DUF4430
go-classifiers:componentextracellular regioncomponentextracellular spacefunctioncobalamin bindingprocesscobalamin metabolic processprocesscobalamin transportprocesscobalt ion transportprocesssmall molecule metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic process
id:BE0000340
name:Protein amnionless
organism:Humans
action:other
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Seetharam B, Yammani RR: Cobalamin transport proteins and their cell-surface receptors. Expert Rev Mol Med. 2003 Jun 13;5(18):1-18.
known-action:unknown
name:Protein amnionless
general-function:Receptor binding
specific-function:Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity).
gene-name:AMN
locus:14q32.3
cellular-location:Membrane
transmembrane-regions:358-378
signal-regions:1-19
theoretical-pi:6.09
molecular-weight:47753.91
chromosome-location:14
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:14604GenAtlasAMNGenBank Gene DatabaseAF328788GenBank Protein Database13507259UniProtKBQ9BXJ7UniProt AccessionAMNLS_HUMAN
synonyms:Amnionless protein precursor
amino-acid-sequence:>lcl|BSEQ0036994|Protein amnionless MGVLGRVLLWLQLCALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLV QEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRS GDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLA VFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACH SALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRL READTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSSAAG LAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELP LPRRLSLVPKAAADSTSHSYFVNPLFAGAEAEA
gene-sequence:>lcl|BSEQ0021258|Protein amnionless (AMN) ATGGGCGTCCTGGGCCGGGTCCTGCTGTGGCTGCAGCTCTGCGCACTGACCCAGGCGGTC TCCAAACTCTGGGTCCCCAACACGGACTTCGACGTCGCAGCCAACTGGAGCCAGAACCGG ACCCCGTGCGCCGGCGGCGCCGTTGAGTTCCCGGCGGACAAGATGGTGTCAGTCCTGGTG CAAGAAGGTCACGCCGTCTCAGACATGCTCCTGCCGCTGGATGGGGAACTCGTCCTGGCT TCAGGAGCCGGATTCGGCGTCTCAGACGTGGGCTCGCACCTGGACTGTGGCGCGGGCGAA CCTGCCGTCTTCCGCGACTCTGACCGCTTCTCCTGGCATGACCCGCACCTGTGGCGCTCT GGGGACGAGGCACCTGGCCTCTTCTTCGTGGACGCCGAGCGCGTGCCCTGCCGCCACGAC GACGTCTTCTTTCCGCCTAGTGCCTCCTTCCGCGTGGGGCTCGGCCCTGGCGCTAGCCCC GTGCGTGTCCGCAGCATCTCGGCTCTGGGCCGGACGTTCACGCGCGACGAGGACCTGGCT GTTTTCCTGGCGTCCCGCGCGGGCCGCCTACGCTTCCACGGGCCGGGCGCGCTGAGCGTG GGCCCCGAGGACTGCGCGGACCCGTCGGGCTGCGTCTGCGGCAACGCGGAGGCGCAGCCG TGGATCTGCGCGGCCCTGCTCCAGCCCCTGGGCGGCCGCTGCCCCCAGGCCGCCTGCCAC AGCGCCCTCCGGCCCCAGGGGCAGTGCTGTGACCTCTGTGGAGCCGTTGTGTTGCTGACC CACGGCCCCGCATTTGACCTGGAGCGGTACCGGGCGCGGATACTGGACACCTTCCTGGGT CTGCCTCAGTACCACGGGCTGCAGGTGGCCGTGTCCAAGGTGCCACGCTCGTCCCGGCTC CGTGAGGCCGATACGGAGATCCAGGTGGTGCTGGTGGAGAATGGGCCCGAGACAGGCGGA GCGGGGCGGCTGGCCCGGGCCCTCCTGGCGGACGTCGCCGAGAACGGCGAGGCCCTCGGC GTCCTGGAGGCGACCATGCGGGAGTCGGGCGCACACGTCTGGGGCAGCTCCGCGGCTGGG CTGGCGGGCGGCGTGGCGGCTGCCGTGCTGCTGGCGCTGCTGGTCCTGCTGGTGGCGCCG CCGCTGCTGCGCCGCGCGGGGAGGCTCAGGTGGAGGAGGCACGAGGCGGCGGCCCCGGCT GGAGCGCCCCTCGGCTTCCGCAACCCGGTGTTCGACGTGACGGCCTCCGAGGAGCTGCCC CTGCCGCGGCGGCTCAGCCTGGTTCCGAAGGCGGCCGCAGACAGCACCAGCCACAGTTAC TTCGTCAACCCTCTGTTCGCCGGGGCCGAGGCCGAGGCCTGA
pfams:
go-classifiers:componentapical plasma membranecomponentendocytic vesiclecomponentendosome membranecomponentextracellular exosomecomponentextracellular spacecomponentintegral component of membranecomponentplasma membranefunctionreceptor bindingprocesscobalamin metabolic processprocesscobalamin transportprocessexcretionprocessGolgi to plasma membrane protein transportprocesslipoprotein metabolic processprocessmulticellular organismal developmentprocessreceptor-mediated endocytosisprocesssmall molecule metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic process
id:BE0000936
name:Cubilin
organism:Humans
action:other
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Seetharam B, Yammani RR: Cobalamin transport proteins and their cell-surface receptors. Expert Rev Mol Med. 2003 Jun 13;5(18):1-18.
known-action:unknown
name:Cubilin
general-function:Transporter activity
specific-function:Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
gene-name:CUBN
locus:10p12.31
cellular-location:Endosome membrane
transmembrane-regions:
signal-regions:1-23
theoretical-pi:5.0
molecular-weight:398732.93
chromosome-location:10
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:2548GenAtlasCUBNGenBank Gene DatabaseAF034611GenBank Protein Database3929529UniProtKBO60494UniProt AccessionCUBN_HUMAN
synonyms:460 kDa receptorIFCRIntestinal intrinsic factor receptorIntrinsic factor-cobalamin receptorIntrinsic factor-vitamin B12 receptor
amino-acid-sequence:>lcl|BSEQ0016258|Cubilin MMNMSLPFLWSLLTLLIFAEVNGEAGELELQRQKRSINLQQPRMATERGNLVFLTGSAQN IEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDL ERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGT PLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGE PKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNG YICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGC HPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKC DSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSG INGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSS SAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGS IKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPL LGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELF LPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCG NGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGER TCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFIT SVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTW HILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSL MLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITV RTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLW LKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHG SAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLR TDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNY TFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREK GFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEY HSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFN ASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ DSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQAC GGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFV EILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGG TFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIRE GNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTH GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA RLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACGG FLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIR DGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADR GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD ICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGN VYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYL ELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRV PGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDN HTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSI GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNS PQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEG NFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDA DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVI TSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPII GQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPH WPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLA TGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQY DNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCG DEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPN DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN VKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYD KNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGST VPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNSSDPD VPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASA VPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKD CTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFS QNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWV LVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSN QVFIKFHADYARRPSAFRLTWDS
gene-sequence:>lcl|BSEQ0016259|Cubilin (CUBN) ATGATGAACATGTCTTTACCTTTTCTTTGGAGTTTGCTTACCTTATTAATATTTGCTGAA GTAAATGGCGAAGCTGGAGAACTTGAGCTGCAGAGACAAAAAAGAAGCATCAATCTCCAA CAGCCTCGAATGGCTACAGAGAGAGGAAATTTGGTGTTTCTTACGGGGTCTGCTCAAAAC ATTGAGTTTAGAACCGGATCCCTGGGAAAAATTAAATTAAATGATGAAGATCTCAGTGAG TGTTTACATCAGATCCAGAAAAACAAAGAAGATATTATAGAGTTAAAAGGGAGTGCAATT GGTCTGCCTCAAAATATATCTAGTCAAATCTATCAGCTTAATTCCAAGCTGGTGGATCTT GAGAGAAAATTCCAAGGCTTGCAGCAGACTGTTGACAAAAAGGTTTGCAGCAGCAATCCT TGCCAGAATGGTGGAACCTGCCTCAATCTGCATGATTCCTTTTTTTGTATCTGTCCCCCA CAGTGGAAGGGTCCTCTCTGCTCAGCTGATGTTAACGAATGTGAGATTTACTCAGGAACA CCCTTGAGCTGCCAGAATGGAGGCACATGTGTTAATACAATGGGAAGTTACAGTTGTCAC TGCCCACCTGAGACGTACGGACCCCAGTGTGCATCCAAATATGACGACTGTGAAGGGGGT TCTGTGGCACGCTGTGTCCATGGCATCTGTGAGGATTTAATGCGAGAGCAAGCTGGAGAG CCCAAGTACAGCTGCGTCTGTGATGCTGGGTGGATGTTTTCACCCAACAGCCCTGCCTGC ACGCTGGACAGAGACGAGTGCAGCTTCCAGCCCGGGCCTTGCTCCACACTTGTGCAGTGT TTCAACACTCAAGGCTCTTTCTACTGTGGGGCCTGTCCAACAGGCTGGCAAGGCAATGGA TATATTTGCGAAGATATCAATGAATGTGAGATAAATAACGGCGGCTGTTCTGTGGCTCCA CCCGTTGAGTGTGTGAATACACCTGGGTCTTCCCACTGCCAGGCCTGTCCACCAGGGTAC CAGGGTGACGGAAGAGTGTGCACACTCACAGACATCTGCTCAGTCAGTAATGGAGGCTGC CACCCAGATGCCTCATGCTCCTCAACTCTAGGTTCCTTACCTCTCTGCACGTGTCTCCCG GGTTATACTGGAAATGGTTATGGGCCAAATGGATGTGTGCAGCTCAGTAATATTTGCCTA AGTCACCCCTGTCTAAATGGACAATGCATCGACACTGTCTCTGGTTATTTTTGTAAGTGT GACTCAGGTTGGACAGGTGTCAACTGTACAGAAAACATCAATGAGTGTTTGAGCAACCCC TGTTTGAATGGAGGAACTTGTGTTGATGGCGTTGATTCTTTCAGTTGTGAATGCACACGT CTCTGGACTGGAGCTCTCTGTCAGGTTCCTCAGCAAGTTTGTGGAGAGTCCCTCTCAGGA ATAAATGGAAGCTTCAGCTACAGGAGCCCGGATGTTGGTTATGTTCATGATGTTAACTGC TTCTGGGTTATCAAAACTGAAATGGGAAAGGTCCTGCGTATCACTTTCACTTTTTTCCGG TTAGAATCCATGGACAACTGTCCACACGAGTTTCTTCAGGTTTATGATGGAGATTCCTCT TCTGCTTTTCAACTTGGAAGATTTTGTGGCTCCAGCCTCCCTCATGAACTCCTCAGCAGT GACAATGCTCTCTATTTTCATCTCTATTCTGAACATTTAAGAAATGGGAGAGGCTTTACA GTAAGATGGGAAACACAGCAACCAGAGTGTGGAGGTATCCTGACTGGTCCTTACGGTTCT ATTAAGTCTCCGGGGTATCCTGGAAACTATCCCCCAGGAAGAGATTGTGTCTGGATTGTT GTAACTAGTCCTGACCTCCTGGTAACATTTACTTTTGGGACCTTGAGCCTCGAGCACCAT GATGACTGCAACAAAGATTACCTTGAGATTCGAGATGGTCCTTTGTATCAGGACCCCCTT CTTGGGAAGTTCTGCACCACTTTCTCTGTCCCACCGCTCCAGACTACTGGCCCCTTTGCC AGAATTCACTTCCATTCAGACTCCCAGATTAGTGACCAAGGCTTCCATATCACCTACTTA ACATCACCTTCGGATCTGCGTTGTGGTGGGAACTACACGGACCCAGAGGGTGAACTCTTC TTGCCTGAGTTGTCTGGGCCTTTCACTCACACCAGGCAATGCGTCTATATGATGAAGCAG CCCCAGGGAGAACAAATACAAATCAACTTCACCCACGTGGAGCTGCAATGCCAGAGTGAC AGTTCTCAGAATTACATTGAGGTTCGAGATGGTGAAACCTTACTTGGAAAAGTCTGTGGC AACGGAACCATCTCTCACATTAAATCCATTACTAATAGTGTCTGGATCAGGTTTAAAATA GATGCTTCTGTTGAAAAAGCTAGTTTCAGAGCTGTTTATCAAGTCGCTTGCGGGGATGAA TTAACTGGAGAAGGGGTCATTCGCTCGCCTTTTTTTCCTAACGTGTATCCTGGAGAAAGA ACCTGTAGGTGGACCATCCACCAGCCCCAAAGCCAAGTCATTCTCCTCAACTTCACTGTC TTTGAAATTGGAAGTTCTGCCCACTGTGAAACAGATTATGTTGAGATTGGTAGCAGTTCC ATTTTGGGTTCTCCTGAAAATAAAAAGTATTGCGGTACAGACATACCTTCATTTATAACA TCTGTGTACAATTTTCTTTATGTCACATTCGTGAAAAGTTCTTCTACTGAAAACCATGGT TTCATGGCTAAGTTCAGTGCTGAGGATTTGGCATGTGGAGAAATTCTTACAGAATCAACA GGGACCATTCAAAGTCCTGGCCATCCAAATGTCTACCCCCACGGTATCAACTGTACTTGG CATATATTAGTCCAACCTAATCACCTGATTCATTTAATGTTCGAAACATTTCATCTGGAG TTTCATTACAATTGCACAAACGACTACTTGGAAGTTTATGACACCGACTCTGAGACATCC CTTGGAAGATACTGTGGAAAGTCGATCCCGCCATCTCTCACAAGCAGTGGTAACTCATTG ATGCTGGTGTTTGTGACTGACTCCGACCTCGCTTATGAAGGCTTCTTAATAAACTATGAA GCAATCAGTGCAGCAACAGCATGTTTGCAAGACTACACAGATGATTTGGGGACATTCACT TCTCCAAACTTCCCCAATAATTATCCCAACAACTGGGAATGCATTTATCGGATCACAGTG AGAACTGGCCAACTGATTGCAGTGCACTTCACAAACTTCTCCTTGGAGGAAGCCATTGGA AACTATTATACAGATTTTCTGGAAATCAGAGATGGAGGCTATGAAAAATCACCATTGCTG GGAATATTCTATGGCTCAAATCTACCCCCAACAATCATCTCTCATAGTAACAAACTATGG TTAAAATTTAAGAGTGACCAAATAGACACAAGGTCTGGATTCTCAGCTTACTGGGATGGG TCATCAACAGGTTGCGGGGGTAATCTCACCACTTCAAGCGGCACGTTCATATCTCCCAAC TACCCGATGCCCTATTACCACAGCTCTGAATGCTACTGGTGGTTGAAATCTAGCCACGGC AGCGCATTTGAACTGGAATTCAAAGACTTTCACTTGGAGCATCATCCAAACTGCACTTTA GATTACCTGGCTGTATATGATGGCCCAAGTAGCAACTCTCATCTGCTAACTCAGCTTTGT GGGGATGAGAAACCCCCTCTTATTCGTTCTAGTGGAGACAGCATGTTTATAAAACTGAGG ACAGATGAAGGTCAGCAAGGACGTGGCTTCAAGGCTGAATACCGGCAGACATGTGAGAAT GTGGTAATAGTCAATCAAACCTATGGCATCTTAGAGAGTATAGGGTATCCGAATCCTTAT TCTGAAAATCAGCATTGCAACTGGACCATCCGGGCAACAACAGGCAACACTGTGAACTAC ACATTTTTAGCATTTGACTTGGAACATCACATAAACTGCTCCACAGATTATTTAGAGCTC TATGATGGACCACGGCAGATGGGACGCTACTGTGGAGTAGACCTGCCCCCTCCAGGGAGT ACTACAAGCTCCAAGCTTCAAGTGCTGCTCCTTACAGATGGGGTTGGCCGCCGTGAGAAA GGATTTCAGATGCAGTGGTTTGTTTACGGTTGTGGTGGAGAGCTGTCTGGGGCCACAGGC TCCTTCAGCAGCCCCGGGTTCCCCAACAGGTATCCACCAAACAAGGAGTGTATCTGGTAC ATTAGGACGGACCCCGGGAGTAGCATTCAGCTCACCATCCATGACTTCGATGTGGAGTAT CATTCAAGGTGCAACTTTGATGTCTTGGAGATCTATGGAGGCCCCGATTTCCACTCTCCC AGAATAGCCCAACTGTGTACCCAGAGATCACCTGAGAACCCCATGCAGGTCTCCAGCACT GGAAATGAGCTAGCAATTCGATTCAAGACCGACTTGTCCATAAATGGGAGAGGCTTCAAT GCGTCATGGCAAGCAGTCACTGGAGGTTGTGGTGGGATTTTCCAGGCTCCCAGTGGAGAG ATTCATTCTCCAAATTACCCCAGTCCTTATAGGAGCAACACAGACTGTTCTTGGGTCATT CGGGTTGACAGAAATCATCGTGTTCTCTTGAACTTCACTGACTTTGATCTTGAACCACAA GACTCTTGTATTATGGCATACGATGGCTTAAGCTCCACAATGTCCCGCCTTGCCAGGACG TGTGGAAGGGAGCAGCTGGCTAACCCCATCGTCTCCTCAGGAAACAGCCTCTTCTTGAGA TTTCAGTCTGGCCCTTCCAGACAGAACAGAGGCTTCCGAGCTCAATTCAGGCAAGCCTGC GGAGGCCACATCCTCACCAGCTCATTTGATACTGTTTCCTCTCCACGGTTCCCTGCCAAT TATCCAAACAATCAGAACTGCAGCTGGATCATTCAAGCGCAACCTCCATTAAATCATATC ACCCTCTCTTTTACCCACTTTGAACTTGAAAGAAGCACAACGTGTGCACGTGACTTTGTA GAAATTTTGGATGGCGGCCACGAAGACGCGCCCCTCCGAGGCCGTTACTGTGGCACCGAC ATGCCCCATCCTATCACATCCTTCAGCAGCGCCCTGACGCTGAGATTCGTCTCTGATTCT AGCATCAGTGCTGGGGGTTTCCACACCACGGTCACCGCATCAGTGTCGGCTTGTGGTGGA ACGTTCTACATGGCTGAAGGCATCTTCAACAGCCCTGGCTACCCAGACATTTATCCCCCT AATGTGGAATGTGTCTGGAACATCGTCAGTTCCCCTGGCAACCGGCTCCAGCTGTCTTTT ATATCTTTCCAGTTGGAAGACTCTCAGGACTGCAGCAGAGATTTTGTGGAGATCCGTGAA GGAAATGCCACGGGTCACTTGGTGGGACGATACTGTGGAAACTCCTTCCCTCTCAATTAT TCTTCCATCGTTGGACATACCCTGTGGGTCAGATTTATCTCAGATGGTTCTGGCAGCGGC ACGGGCTTCCAGGCCACATTTATGAAGATATTTGGCAATGATAATATTGTGGGAACTCAT GGGAAAGTCGCCTCTCCTTTCTGGCCTGAAAACTACCCACATAACTCCAATTACCAATGG ACAGTAAATGTGAATGCATCTCACGTTGTCCATGGTAGAATCTTGGAGATGGACATAGAA GAAATACAAAACTGCTATTATGACAAATTAAGGATCTATGATGGGCCTAGCATTCACGCC CGCCTAATTGGAGCTTACTGTGGTACCCAGACTGAATCTTTCAGCTCCACTGGAAATTCT TTGACATTTCATTTTTACTCCGACTCTTCAATCTCAGGGAAGGGATTCCTTCTGGAGTGG TTTGCAGTGGATGCACCTGATGGTGTTTTACCTACCATTGCTCCAGGTGCTTGTGGTGGC TTCCTGAGGACGGGAGATGCACCCGTGTTTCTCTTCTCCCCGGGCTGGCCTGACAGTTAC AGTAATAGAGTGGACTGTACGTGGCTCATCCAGGCTCCCGACTCTACCGTGGAACTCAAC ATTCTTTCCCTGGACATTGAATCTCACCGAACGTGTGCCTATGATAGCCTTGTGATACGA GATGGAGATAATAACTTGGCCCAGCAGCTAGCAGTTCTCTGTGGCAGAGAGATCCCTGGG CCCATCCGGTCTACTGGAGAGTACATGTTCATCCGCTTCACCTCGGACTCCAGTGTAACC AGGGCAGGCTTCAATGCATCCTTTCACAAGAGCTGCGGTGGATATTTGCATGCAGACAGA GGGATCATCACGTCCCCCAAGTATCCAGAGACTTACCCATCCAACCTCAACTGTTCTTGG CACGTCCTGGTCCAAAGTGGCCTGACCATTGCTGTCCATTTTGAACAGCCTTTCCAGATT CCAAATGGAGATTCTTCTTGCAACCAGGGGGATTACTTGGTGCTAAGAAATGGTCCTGAT ATCTGTTCTCCACCCTTGGGACCCCCTGGAGGAAATGGTCATTTTTGTGGCAGTCATGCT TCATCAACTCTGTTCACCTCGGATAATCAAATGTTTGTTCAGTTTATTTCTGATCACAGT AATGAAGGGCAAGGATTTAAAATCAAATATGAGGCAAAGAGTTTAGCCTGTGGGGGCAAC GTCTACATCCATGATGCTGATTCTGCTGGGTATGTGACCTCCCCCAACCACCCTCATAAT TATCCCCCGCACGCTGATTGCATTTGGATCTTAGCGGCTCCACCGGAAACACGCATACAG CTGCAATTTGAAGATCGATTCGATATTGAAGTAACACCCAACTGTACTTCCAACTACCTT GAGTTGCGGGATGGAGTGGATTCGGATGCACCAATACTTTCCAAATTTTGTGGGACATCT TTGCCCAGCAGTCAGTGGTCCTCAGGAGAGGTTATGTATTTGAGATTTCGATCTGACAAC AGCCCCACACATGTGGGATTCAAGGCCAAGTATTCTATAGCTCAGTGTGGGGGAAGAGTA CCAGGGCAAAGTGGTGTTGTTGAAAGCATTGGACATCCAACACTTCCATACAGAGACAAC TTATTCTGTGAGTGGCATCTCCAGGGGCTCTCTGGACACTATCTCACCATCTCTTTTGAA GACTTTAACCTTCAGAATTCTTCTGGCTGTGAAAAAGACTTCGTGGAGATCTGGGACAAT CATACCTCTGGAAACATCTTGGGCAGATACTGTGGAAACACCATTCCTGACAGCATAGAC ACTTCTAGCAATACTGCTGTGGTCAGGTTTGTCACAGACGGCTCTGTGACTGCCTCAGGA TTCAGACTGCGATTTGAATCCAGTATGGAAGAGTGTGGTGGGGATCTTCAGGGCTCTATT GGAACATTTACTTCTCCCAACTACCCGAACCCAAATCCTCATGGCCGGATCTGCGAGTGG AGAATCACTGCCCCGGAGGGAAGGCGGATCACCCTAATGTTTAACAACCTGAGGCTGGCC ACGCATCCGTCCTGCAACAATGAGCATGTGATAGTATTCAATGGCATTAGAAGTAACTCA CCCCAGCTAGAGAAACTGTGTAGTAGTGTGAATGTAAGCAATGAGATTAAATCTTCAGGA AACACAATGAAAGTCATTTTTTTCACGGATGGATCCAGGCCATATGGCGGCTTCACTGCT TCCTATACCTCCAGTGAAGATGCAGTGTGTGGTGGGTCTCTTCCAAATACTCCTGAAGGA AACTTTACTTCTCCTGGCTATGACGGAGTCAGGAATTACTCAAGAAACCTGAACTGCGAA TGGACTCTCAGCAATCCAAATCAGGGAAATTCATCCATTTCCATTCACTTTGAAGATTTT TACCTAGAAAGTCACCAAGACTGTCAATTTGATGTCCTCGAGTTTCGAGTGGGTGATGCT GATGGGCCCCTGATGTGGAGACTTTGTGGTCCTTCAAAGCCTACATTGCCATTGGTTATA CCTTATTCTCAGGTATGGATTCACTTTGTCACCAACGAACGTGTAGAACACATTGGATTC CATGCAAAGTATTCCTTTACAGATTGTGGCGGAATACAGATAGGTGACAGTGGAGTGATC ACAAGCCCCAACTATCCAAATGCTTATGACAGCCTGACCCACTGCTCTTCGCTGTTGGAG GCCCCACAAGGGCACACCATCACTCTCACATTTAGTGACTTTGATATTGAACCCCATACA ACTTGTGCTTGGGACTCTGTCACTGTCAGGAATGGTGGGTCCCCTGAATCACCCATCATA GGACAATACTGTGGAAATTCAAACCCCAGGACAATACAGTCAGGTTCCAATCAGCTGGTC GTGACTTTTAACTCAGACCATTCATTGCAAGGTGGTGGATTTTATGCTACGTGGAACACA CAAACTTTAGGTTGTGGTGGAATATTTCATTCTGATAATGGTACAATCAGATCCCCTCAC TGGCCTCAGAATTTTCCCGAAAACAGCAGATGTTCCTGGACGGCCATTACTCACAAAAGT AAACACTTGGAGATCAGCTTTGACAACAACTTCCTAATCCCCAGCGGTGATGGACAATGT CAGAATAGCTTCGTGAAGGTGTGGGCAGGAACTGAGGAGGTGGACAAAGCCCTGCTAGCC ACTGGCTGTGGGAACGTGGCTCCGGGTCCCGTTATCACACCAAGTAACACATTCACTGCC GTCTTCCAGTCTCAGGAGGCACCAGCTCAGGGCTTCTCCGCGTCCTTTGTTAGCCGATGT GGAAGTAATTTCACTGGCCCTTCAGGTTACATCATTTCTCCAAATTACCCAAAACAATAT GACAACAACATGAATTGCACCTATGTCATAGAGGCTAATCCTCTGTCAGTGGTCCTCTTG ACTTTTGTGTCCTTCCACTTAGAAGCTCGTTCCGCTGTGACGGGAAGCTGTGTCAACGAT GGCGTGCACATTATCAGAGGTTACAGCGTCATGTCCACCCCATTTGCTACTGTGTGTGGG GATGAGATGCCAGCTCCCCTCACCATCGCTGGGCCGGTTCTGCTTAACTTCTACTCCAAC GAGCAAATCACAGACTTCGGATTCAAGTTTTCCTATAGGATAATCTCCTGTGGTGGTGTG TTCAATTTCTCTTCTGGAATCATCACAAGTCCTGCCTATTCATACGCAGACTACCCAAAT GATATGCACTGTCTGTATACCATCACCGTTAGTGACGACAAGGTGATCGAGCTCAAGTTC AGTGATTTTGATGTGGTTCCCTCCACCTCCTGCTCCCATGACTACCTGGCAATTTACGAT GGTGCCAATACCAGCGATCCCCTTCTTGGCAAATTCTGCGGTTCCAAGCGCCCACCAAAT GTGAAGAGCAGCAATAATAGTATGCTCCTGGTGTTCAAGACAGATTCATTTCAGACAGCA AAAGGCTGGAAGATGTCTTTCCGGCAGACATTGGGGCCTCAGCAAGGATGTGGTGGTTAT CTGACAGGCTCGAATAATACCTTTGCCTCTCCTGATTCTGATTCGAATGGAATGTATGAC AAGAATTTAAACTGTGTATGGATCATAATTGCACCTGTAAACAAAGTAATTCACCTCACC TTCAATACATTTGCTCTGGAGGCAGCAAGTACTAGGCAAAGATGCCTTTATGATTATGTA AAGTTATATGATGGGGATAGTGAAAATGCGAACTTGGCTGGAACGTTTTGTGGTTCCACA GTACCTGCTCCTTTTATCTCTTCTGGTAACTTCCTTACGGTTCAATTCATCAGTGACTTA ACATTAGAGAGGGAAGGATTTAATGCTACATACACCATCATGGACATGCCTTGTGGTGGA ACATACAATGCAACTTGGACCCCACAAAATATTTCATCACCCAATTCATCAGACCCAGAT GTCCCATTTTCCATCTGTACTTGGGTCATTGATTCCCCTCCGCATCAGCAGGTCAAGATA ACTGTGTGGGCATTACAGCTGACCTCGCAAGACTGCACGCAGAATTACTTACAGCTTCAG GACTCACCGCAGGGTCACGGAAATTCAAGATTTCAGTTCTGTGGCAGAAATGCTTCGGCT GTGCCAGTGTTTTATTCTTCTATGAGTACTGCAATGGTCATTTTCAAATCTGGAGTTGTA AACAGAAACTCTAGAATGAGTTTCACCTATCAGATTGCAGATTGCAACAGAGACTATCAC AAGGCATTTGGCAACCTGAGAAGCCCTGGATGGCCAGATAACTACGACAATGACAAGGAT TGCACCGTTACTCTCACAGCCCCCCAGAACCACACCATTTCCCTCTTTTTTCATTCACTT GGCATCGAGAACTCAGTTGAATGCAGAAACGATTTCTTGGAGGTGAGAAATGGAAGTAAC AGCAATTCACCATTACTGGGCAAGTACTGTGGAACTCTGCTGCCAAACCCTGTCTTCTCT CAAAATAATGAACTATACCTACGATTTAAGAGTGATAGTGTAACTTCTGATCGTGGATAT GAAATCATCTGGACTTCATCACCCTCTGGATGTGGTGGAACTCTTTATGGAGACAGAGGC TCATTCACCAGCCCCGGCTATCCAGGCACATACCCAAACAACACGTACTGCGAGTGGGTC CTTGTTGCTCCTGCTGGAAGGCTTGTCACCATCAACTTCTACTTCATCAGCATTGACGAT CCAGGAGACTGTGTCCAGAACTATCTCACACTCTATGATGGGCCCAACGCCAGCTCTCCA TCCTCTGGACCATACTGCGGAGGCGACACCAGCATAGCTCCCTTCGTGGCTTCCTCAAAT CAGGTCTTCATAAAATTTCATGCTGATTATGCACGGCGTCCATCCGCATTCCGATTAACT TGGGACAGCTAA
pfams:PF00008EGFPF07645EGF_CAPF00431CUBPF12947EGF_3
go-classifiers:componentapical plasma membranecomponentbrush border membranecomponentcoated pitcomponentcytosolcomponentendocytic vesiclecomponentendoplasmic reticulumcomponentendosome membranecomponentextracellular exosomecomponentextrinsic component of external side of plasma membranecomponentGolgi apparatuscomponentlysosomal lumencomponentlysosomal membranecomponentmembranecomponentplasma membranefunctioncalcium ion bindingfunctioncobalamin bindingfunctionprotein homodimerization activityfunctionreceptor activityfunctiontransporter activityprocesscholesterol metabolic processprocesscobalamin metabolic processprocesscobalamin transportprocesslipoprotein metabolic processprocesslipoprotein transportprocessreceptor-mediated endocytosisprocesssmall molecule metabolic processprocesssteroid metabolic processprocesstissue homeostasisprocessvitamin D metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic process
id:BE0002175
name:Methylmalonic aciduria and homocystinuria type C protein
organism:Humans
action:other/unknown
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Lerner-Ellis JP, Tirone JC, Pawelek PD, Dore C, Atkinson JL, Watkins D, Morel CF, Fujiwara TM, Moras E, Hosack AR, Dunbar GV, Antonicka H, Forgetta V, Dobson CM, Leclerc D, Gravel RA, Shoubridge EA, Coulton JW, Lepage P, Rommens JM, Morgan K, Rosenblatt DS: Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type. Nat Genet. 2006 Jan;38(1):93-100. Epub 2005 Nov 27.
known-action:unknown
name:Methylmalonic aciduria and homocystinuria type C protein
general-function:Cobalamin binding
specific-function:May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
gene-name:MMACHC
locus:1p34.1
cellular-location:Cytoplasm
transmembrane-regions:
signal-regions:
theoretical-pi:7.92
molecular-weight:31728.095
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:24525GenAtlasMMACHCGenBank Gene DatabaseAL080062GenBank Protein Database52545527UniProtKBQ9Y4U1UniProt AccessionMMAC_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0004268|Methylmalonic aciduria and homocystinuria type C protein MEPKVAELKQKIEDTLCPFGFEVYPFQVAWYNELLPPAFHLPLPGPTLAFLVLSTPAMFD RALKPFLQSCHLRMLTDPVDQCVAYHLGRVRESLPELQIEIIADYEVHPNRRPKILAQTA AHVAGAAYYYQRQDVEADPWGNQRISGVCIHPRFGGWFAIRGVVLLPGIEVPDLPPRKPH DCVPTRADRIALLEGFNFHWRDWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGLAQPS EKPSSPSPDLPFTTPAPKKPGNPSRARSWLSPRVSPPASPGP
gene-sequence:>lcl|BSEQ0011573|Methylmalonic aciduria and homocystinuria type C protein (MMACHC) ATGGAGCCGAAAGTCGCAGAGCTGAAGCAGAAGATCGAGGACACGCTATGTCCTTTTGGC TTCGAGGTTTACCCCTTCCAGGTGGCATGGTACAATGAACTCTTGCCTCCAGCCTTCCAC CTACCGCTGCCAGGACCTACCCTGGCCTTCCTGGTACTCAGCACGCCTGCCATGTTTGAC CGGGCCCTCAAGCCCTTCTTGCAGAGCTGCCACCTCCGAATGCTGACTGACCCAGTGGAC CAGTGTGTGGCCTACCATCTGGGCCGTGTTAGAGAGAGCCTCCCAGAGCTGCAGATAGAA ATCATTGCTGACTACGAGGTGCACCCCAACCGACGCCCCAAGATCCTGGCCCAGACAGCA GCCCATGTAGCTGGGGCTGCTTACTACTACCAACGACAAGATGTGGAGGCTGACCCATGG GGGAACCAGCGCATATCAGGTGTGTGCATACACCCCCGATTTGGGGGCTGGTTTGCCATC CGAGGGGTAGTGCTGCTGCCAGGGATAGAGGTGCCAGATCTGCCACCCAGAAAACCTCAT GACTGTGTACCTACAAGAGCTGACCGTATCGCCCTACTCGAAGGCTTCAATTTCCACTGG CGTGATTGGACTTACCGGGATGCTGTGACACCCCAGGAGCGCTACTCAGAAGAGCAGAAG GCCTACTTCTCCACTCCACCTGCCCAACGATTGGCCCTATTGGGCTTGGCTCAGCCCTCA GAGAAGCCTAGTTCTCCCTCCCCGGACCTTCCCTTTACCACACCCGCCCCCAAGAAGCCT GGGAATCCCAGCAGAGCCCGGAGCTGGCTCAGCCCCAGGGTCTCACCACCTGCATCCCCT GGCCCTTGA
pfams:PF16690MMACHC
go-classifiers:componentcytosolcomponentmitochondrionfunctioncobalamin bindingprocesscobalamin biosynthetic processprocesscobalamin metabolic processprocesssmall molecule metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic process
载体
BE0000362Transcobalamin-2HumanssubstrateA169008415778Begley JA, Colligan PD, Chu RC: Transcobalamin II mediated delivery of albumin-bound hydroxocobalamin to human liver cells. Proc Soc Exp Biol Med. 1993 Nov;204(2):206-10.A169015126165Skouby AP, Hippe E, Olesen H: Antibody to transcobalamin II and B12 binding capacity in patients treated with hydroxocobalamin. Blood. 1971 Dec;38(6):769-74.A169025488577Hippe E, Olesen H, Skouby A: [Occurrence of antibodies against transcobalamin II in relation to the number of and the intervals between depot therapy with hydroxocobalamin]. Nord Med. 1970 Dec 3;84(49):1570.A169033338997Brown KL, Marques HM, Jacobsen DW: Heteronuclear NMR studies of cobalamins. 31P NMR observations of cobalamins bound to a haptocorrin from chicken serum. J Biol Chem. 1988 Feb 5;263(4):1872-7.A169048487649Chu RC, Begley JA, Colligan PD, Hall CA: The methylcobalamin metabolism of cultured human fibroblasts. Metabolism. 1993 Mar;42(3):315-9.A29314585166Seetharam B, Yammani RR: Cobalamin transport proteins and their cell-surface receptors. Expert Rev Mol Med. 2003 Jun 13;5(18):1-18.unknownTranscobalamin-2Metal ion bindingPrimary vitamin B12-binding and transport protein. Delivers cobalamin to cells.TCN222q12.2Secreted1-186.8947534.5422HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:11653GenAtlasTCN2GenBank Gene DatabaseM60396GenBank Protein Database339196UniProtKBP20062UniProt AccessionTCO2_HUMANTC IITC-2TC2TCIITranscobalamin II>lcl|BSEQ0037000|Transcobalamin-2 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF GNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI ELRLVSW>lcl|BSEQ0010261|Transcobalamin-2 (TCN2) ATGAGGCACCTTGGGGCCTTCCTCTTCCTTCTGGGGGTCCTGGGGGCCCTCACTGAGATG TGTGAAATACCAGAGATGGACAGCCATCTGGTAGAGAAGTTGGGCCAGCACCTCTTACCT TGGATGGACCGGCTTTCCCTGGAGCACTTGAACCCCAGCATCTATGTGGGCCTACGCCTC TCCAGTCTGCAGGCTGGGACCAAGGAAGACCTCTACCTGCACAGCCTCAAGCTTGGTTAC CAGCAGTGCCTCCTAGGGTCTGCCTTCAGCGAGGATGACGGTGACTGCCAGGGCAAGCCT TCCATGGGCCAGCTGGCCCTCTACCTGCTCGCTCTCAGAGCCAACTGTGAGTTTGTCAGG GGCCACAAGGGGGACAGGCTGGTCTCACAGCTCAAATGGTTCCTGGAGGATGAGAAGAGA GCCATTGGGCATGATCACAAGGGCCACCCCCACACTAGCTACTACCAGTATGGCCTGGGC ATTCTGGCCCTGTGTCTCCACCAGAAGCGGGTCCATGACAGCGTGGTGGACAAACTTCTG TATGCTGTGGAACCTTTCCACCAGGGCCACCATTCTGTGGACACAGCAGCCATGGCAGGC TTGGCATTCACCTGTCTGAAGCGCTCAAACTTCAACCCTGGTCGGAGACAACGGATCACC ATGGCCATCAGAACAGTGCGAGAGGAGATCTTGAAGGCCCAGACCCCCGAGGGCCACTTT GGGAATGTCTACAGCACCCCATTGGCATTACAGTTCCTCATGACTTCCCCCATGCGTGGG GCAGAACTGGGAACAGCATGTCTCAAGGCGAGGGTTGCTTTGCTGGCCAGTCTGCAGGAT GGAGCCTTCCAGAATGCTCTCATGATTTCCCAGCTGCTGCCCGTTCTGAACCACAAGACC TACATTGATCTGATCTTCCCAGACTGTCTGGCACCACGAGTCATGTTGGAACCAGCTGCT GAGACCATTCCTCAGACCCAAGAGATCATCAGTGTCACGCTGCAGGTGCTTAGTCTCTTG CCGCCGTACAGACAGTCCATCTCTGTTCTGGCCGGGTCCACCGTGGAAGATGTCCTGAAG AAGGCCCATGAGTTAGGAGGATTCACATATGAAACACAGGCCTCCTTGTCAGGCCCCTAC TTAACCTCCGTGATGGGGAAAGCGGCCGGAGAAAGGGAGTTCTGGCAGCTTCTCCGAGAC CCCAACACCCCACTGTTGCAAGGTATTGCTGACTACAGACCCAAGGATGGAGAAACCATT GAGCTGAGGCTGGTTAGCTGGTAGPF01122Cobalamin_bindPF14478DUF4430componentendosomecomponentextracellular exosomecomponentextracellular regioncomponentextracellular spacecomponentlysosomal lumenfunctioncobalamin bindingfunctionmetal ion bindingprocesscobalamin metabolic processprocesscobalamin transportprocesscobalt ion transportprocesssmall molecule metabolic processprocessvitamin metabolic processprocesswater-soluble vitamin metabolic process
运输工具
药物反应
效应
不良反应