ID

DB00208|APRD01257|DB00208|

名称

Ticlopidine

描述

Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.

cas号

55142-85-3

唯一标识码

OM90ZUW7M1

状态

solid

组

approved,

指示

Used in patients, who have had a stroke or stroke precursors and who cannot take aspirin or aspirin has not worked, to try to prevent another thrombotic stroke.

药效学

Ticlopidine is a prodrug that is metabolised to an as yet undetermined metabolite that acts as a platelet aggregation inhibitor. Inhibition of platelet aggregation causes a prolongation of bleeding time. In its prodrug form, ticlopidine has no significant in vitro activity at the concentrations attained in vivo.

作用机制

The active metabolite of ticlopidine prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of ticlopidine.

毒性

Single oral doses of ticlopidine at 1600 mg/kg and 500 mg/kg were lethal to rats and mice, respectively. Symptoms of acute toxicity were GI hemorrhage, convulsions, hypothermia, dyspnea, loss of equilibrium and abnormal gait. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.

代谢

Ticlopidine is metabolized extensively by the liver with only trace amounts of intact drug detected. At least 20 metabolites have been identified.

吸收

Absorption is greater than 80%. Food increases absorption by approximately 20%.

半衰期

Half-life following a single 250-mg dose is approximately 7.9 hours in subjects 20 to 43 years of age and 12.6 hours in subjects 65 to 76 years of age. With repeated dosing (250 mg twice a day), half-life is about 4 days in subjects 20 to 43 years of age and about 5 days in subjects 65 to 76 years of age.

分类

description:This compound belongs to the class of organic compounds known as thienopyridines. These are heterocyclic compounds containing a thiophene ring fused to a pyridine ring. Thiophene is 5-membered ring consisting of four carbon atoms and one sulfur atom. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
direct-parent:Thienopyridines
kingdom:Organic compounds
superclass:Organoheterocyclic compounds
class:Thienopyridines
subclass:
alternative-parent:Aralkylamines
alternative-parent:Aryl chlorides
alternative-parent:Azacyclic compounds
alternative-parent:Benzylamines
alternative-parent:Chlorobenzenes
alternative-parent:Heteroaromatic compounds
alternative-parent:Hydrocarbon derivatives
alternative-parent:Organochlorides
alternative-parent:Organopnictogen compounds
alternative-parent:Phenylmethylamines
alternative-parent:Pyridines and derivatives
alternative-parent:Thiophenes
alternative-parent:Trialkylamines
substituent:Amine
substituent:Aralkylamine
substituent:Aromatic heteropolycyclic compound
substituent:Aryl chloride
substituent:Aryl halide
substituent:Azacycle
substituent:Benzenoid
substituent:Benzylamine
substituent:Chlorobenzene
substituent:Halobenzene
substituent:Heteroaromatic compound
substituent:Hydrocarbon derivative
substituent:Monocyclic benzene moiety
substituent:Organic nitrogen compound
substituent:Organochloride
substituent:Organohalogen compound
substituent:Organonitrogen compound
substituent:Organopnictogen compound
substituent:Phenylmethylamine
substituent:Pyridine
substituent:Tertiary aliphatic amine
substituent:Tertiary amine
substituent:Thienopyridine
substituent:Thiophene

消除途径

Ticlopidine is eliminated mostly in the urine (60%) and somewhat in the feces (23%).

种类

Antiplatelet agents
D010975
Blood and Blood Forming Organs

Cardiovascular Agents
D002317
Chemically-Induced Disorders
D064419
Cytochrome P-450 CYP1A2 Inhibitors
D065609
Cytochrome P-450 CYP1A2 Inhibitors (strength unknown)

Cytochrome P-450 CYP2B6 Inhibitors
D065686
Cytochrome P-450 CYP2B6 Inhibitors (moderate)

Cytochrome P-450 CYP2B6 Inhibitors (strong)

Cytochrome P-450 CYP2C19 Inhibitors
D065689
Cytochrome P-450 CYP2C19 Inhibitors (moderate)

Cytochrome P-450 CYP2C19 Inhibitors (strong)

Cytochrome P-450 CYP2C19 Substrates

Cytochrome P-450 CYP2C8 Inhibitors
D065687
Cytochrome P-450 CYP2C8 Inhibitors (weak)

Cytochrome P-450 CYP2C9 Inhibitors
D065688
Cytochrome P-450 CYP2C9 Inhibitors (weak)

Cytochrome P-450 CYP2D6 Inhibitors
D065690
Cytochrome P-450 CYP2D6 Inhibitors (strength unknown)

Cytochrome P-450 CYP2D6 Substrates

Cytochrome P-450 CYP2E1 Inhibitors
D065691
Cytochrome P-450 CYP2E1 Inhibitors (weak)

Cytochrome P-450 CYP3A Substrates

Cytochrome P-450 CYP3A4 Substrates

Cytochrome P-450 CYP3A4 Substrates (strength unknown)

Cytochrome P-450 Enzyme Inhibitors
D065607
Cytochrome P-450 Substrates

Decreased Platelet Aggregation

Drugs that are Mainly Renally Excreted

Enzyme Inhibitors
D004791
Fibrin Modulating Agents
D050299
Hematologic Agents
D006401
Heterocyclic Compounds, Fused-Ring
D000072471
Neurotransmitter Agents
D018377
Platelet Aggregation Inhibitors Excl. Heparin

Purinergic Agents
D058905
Purinergic Antagonists
D058914
Purinergic P2 Receptor Antagonists
D058919
Purinergic P2Y Receptor Antagonists
D058921
Pyridines
D011725
Sulfur Compounds
D013457
Thienopyridines
D058924
Thiophenes
D013876

盐类

DBSALT000179Ticlopidine hydrochlorideA1L4914FMF53885-35-1MTKNGOHFNXIVOS-UHFFFAOYSA-N300.247299.030225589

蛋白质结合

Binds reversibly (98%) to plasma proteins, mainly to serum albumin and lipoproteins. The binding to albumin and lipoproteins is nonsaturable over a wide concentration range. Ticlopidine also binds to alpha-1 acid glycoprotein (about 15% or less).

清除

Ticlopidine clearance was not quantified, but clearance decreases with age.

同义词

language:spanish; code:inn; name;Ticlopidina
language:english/french; code:inn; name;Ticlopidine
language:latin; code:inn; name;Ticlopidinum

国际品牌

配送量

The volume of distribution was not quantified.

产品

name:Alti-ticlopidine - Tab 250mg
labeller:Altimed Pharma Inc.
ndc-id:
ndc-product-code:
dpd-id:02194422
ema-product-code:
ema-ma-number:
started-marketing-on:1996-12-31
ended-marketing-on:2005-05-27
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Dom-ticlopidine
labeller:Dominion Pharmacal
ndc-id:
ndc-product-code:
dpd-id:02243808
ema-product-code:
ema-ma-number:
started-marketing-on:2001-05-23
ended-marketing-on:2016-10-25
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Mylan-ticlopidine
labeller:Mylan Pharmaceuticals
ndc-id:
ndc-product-code:
dpd-id:02239744
ema-product-code:
ema-ma-number:
started-marketing-on:1999-03-04
ended-marketing-on:2017-01-09
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Nu-ticlopidine 250 mg
labeller:Nu Pharm Inc
ndc-id:
ndc-product-code:
dpd-id:02237560
ema-product-code:
ema-ma-number:
started-marketing-on:1998-06-09
ended-marketing-on:2012-09-04
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:PMS-ticlopidine
labeller:Pharmascience Inc
ndc-id:
ndc-product-code:
dpd-id:02243327
ema-product-code:
ema-ma-number:
started-marketing-on:2001-02-23
ended-marketing-on:2016-10-28
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Sandoz Ticlopidine
labeller:Sandoz Canada Incorporated
ndc-id:
ndc-product-code:
dpd-id:02243587
ema-product-code:
ema-ma-number:
started-marketing-on:2001-05-14
ended-marketing-on:2011-10-21
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Teva-ticlopidine
labeller:TEVA Canada Limited
ndc-id:
ndc-product-code:
dpd-id:02236848
ema-product-code:
ema-ma-number:
started-marketing-on:2002-07-30
ended-marketing-on:2018-05-02
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Ticlid
labeller:Physicians Total Care, Inc.
ndc-id:
ndc-product-code:54868-3783
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1996-06-05
ended-marketing-on:2001-06-30
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:NDA019979
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlid
labeller:Genentech, Inc.
ndc-id:
ndc-product-code:0004-0018
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1991-10-31
ended-marketing-on:2011-07-18
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:NDA019979
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlid 250mg Tablets
labeller:Hoffmann La Roche
ndc-id:
ndc-product-code:
dpd-id:02162776
ema-product-code:
ema-ma-number:
started-marketing-on:1995-12-31
ended-marketing-on:2006-07-25
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Ticlid Tab 250mg
labeller:Syntex Inc.
ndc-id:
ndc-product-code:
dpd-id:01911759
ema-product-code:
ema-ma-number:
started-marketing-on:1992-12-31
ended-marketing-on:1996-09-30
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Ticlopidine
labeller:Sanis Health Inc
ndc-id:
ndc-product-code:
dpd-id:02343045
ema-product-code:
ema-ma-number:
started-marketing-on:2010-02-16
ended-marketing-on:2014-08-01
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Ticlopidine
labeller:Aa Pharma Inc
ndc-id:
ndc-product-code:
dpd-id:02237701
ema-product-code:
ema-ma-number:
started-marketing-on:1998-03-30
ended-marketing-on:
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Ticlopidine Hydrochloride
labeller:Av Kare, Inc.
ndc-id:
ndc-product-code:42291-803
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-03-20
ended-marketing-on:2015-06-09
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:ANDA075149
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlopidine Hydrochloride
labeller:Genpharm Ulc
ndc-id:
ndc-product-code:55567-054
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2015-11-01
ended-marketing-on:2015-11-30
dosage-form:Tablet, coated
strength:250 mg/1
route:Oral
fda-application-number:ANDA075161
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlopidine Hydrochloride
labeller:Teva
ndc-id:
ndc-product-code:0093-0154
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1999-09-07
ended-marketing-on:2015-09-30
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:ANDA075149
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlopidine Hydrochloride
labeller:Carilion Materials Management
ndc-id:
ndc-product-code:68151-0079
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1999-09-07
ended-marketing-on:
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:ANDA075149
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlopidine Hydrochloride
labeller:Eon Labs, Inc.
ndc-id:
ndc-product-code:0185-0115
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1999-08-20
ended-marketing-on:2015-12-31
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:ANDA075326
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlopidine hydrochloride
labeller:Apotex Corp.
ndc-id:
ndc-product-code:60505-0027
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1999-07-01
ended-marketing-on:2012-04-30
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:ANDA075089
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlopidine Hydrochloride
labeller:Sun Pharmaceutical Industries, Inc.
ndc-id:
ndc-product-code:57664-327
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2002-09-26
ended-marketing-on:2016-05-31
dosage-form:Tablet, film coated
strength:250 mg/1
route:Oral
fda-application-number:ANDA075526
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Ticlopidine-250
labeller:Pro Doc Limitee
ndc-id:
ndc-product-code:
dpd-id:02238208
ema-product-code:
ema-ma-number:
started-marketing-on:1999-11-18
ended-marketing-on:2010-07-13
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD

混合物

name:Ticlid
ingredients:Ticlopidine
name:Ticlid
ingredients:Ticlopidine
name:Ticlopidine Hydrochloride
ingredients:Ticlopidine
name:Ticlopidine Hydrochloride
ingredients:Ticlopidine
name:Ticlopidine Hydrochloride
ingredients:Ticlopidine
name:Ticlopidine Hydrochloride
ingredients:Ticlopidine
name:Ticlopidine Hydrochloride
ingredients:Ticlopidine
name:Ticlopidine hydrochloride
ingredients:Ticlopidine
name:Ticlopidine Hydrochloride
ingredients:Ticlopidine
name:Ticlid Tab 250mg
ingredients:Ticlopidine
name:Ticlid 250mg Tablets
ingredients:Ticlopidine
name:Alti-ticlopidine - Tab 250mg
ingredients:Ticlopidine
name:Nu-ticlopidine 250 mg
ingredients:Ticlopidine
name:Ticlopidine-250
ingredients:Ticlopidine
name:Sandoz Ticlopidine
ingredients:Ticlopidine
name:Ticlopidine
ingredients:Ticlopidine
name:PMS-ticlopidine
ingredients:Ticlopidine
name:Dom-ticlopidine
ingredients:Ticlopidine
name:Mylan-ticlopidine
ingredients:Ticlopidine
name:Teva-ticlopidine
ingredients:Ticlopidine
name:Ticlopidine
ingredients:Ticlopidine

包装者

name:Apotex Inc.
url:http://www.apotex.com
name:AQ Pharmaceuticals Inc.
url:http://www.aqpharmaceuticals.com
name:Caraco Pharmaceutical Labs
url:http://www.caraco.com
name:Eon Labs
url:
name:F Hoffmann-La Roche Ltd.
url:http://www.roche.com
name:Major Pharmaceuticals
url:http://www.majorpharmaceuticals.com
name:Mylan
url:http://www.mylan.com
name:Physicians Total Care Inc.
url:http://www.physicianstotalcare.com
name:Resource Optimization and Innovation LLC
url:
name:Sandhills Packaging Inc.
url:http://www.sandhillspackaging.com
name:Teva Pharmaceutical Industries Ltd.
url:http://www.tevapharm.com
name:Torpharm Inc.
url:

生产者

generic:否; url:; name;Roche palo alto llc
generic:是; url:; name;Actavis elizabeth llc
generic:是; url:; name;Apotex inc
generic:是; url:; name;Caraco pharmaceutical laboratories ltd
generic:是; url:; name;Genpharm inc
generic:是; url:; name;Mylan pharmaceuticals inc
generic:是; url:; name;Sandoz inc
generic:是; url:; name;Teva pharmaceuticals usa inc
generic:是; url:; name;Watson laboratories inc

价格

Ticlopidine 250 mg tablet
1.86(单位：USD）
tablet
Ticlopidine HCl 250 mg tablet
2.1(单位：USD）
tablet
Ticlid 250 mg tablet
2.61(单位：USD）
tablet
Ticlid 30 250 mg tablet Bottle
87.36(单位：USD）
bottle
Apo-Ticlopidine 250 mg Tablet
0.72(单位：USD）
tablet
Mylan-Ticlopidine 250 mg Tablet
0.72(单位：USD）
tablet
Novo-Ticlopidine 250 mg Tablet
0.72(单位：USD）
tablet
Nu-Ticlopidine 250 mg Tablet
0.72(单位：USD）
tablet
Sandoz Ticlopidine 250 mg Tablet
0.72(单位：USD）
tablet
Ticlopidine 250 mg Tablet
0.72(单位：USD）
tablet

受影响的生物体

Humans and other mammals

剂量

form:Pill
route:
strength:250 MG
form:Capsule
route:
strength:250 mg
form:Tablet, coated
route:Oral
strength:250 mg
form:Tablet, film coated
route:Oral
strength:250 mg/1
form:Tablet
route:Oral
strength:250 mg
form:Tablet
route:Oral
strength:
form:Tablet, film coated
route:Oral
strength:
form:Tablet, film coated
route:Oral
strength:250 MG
form:Tablet, coated
route:Oral
strength:250 mg/1

atc代码

Platelet aggregation inhibitors excl. heparin
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
BLOOD AND BLOOD FORMING ORGANS

fda标签

//s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00208.pdf?1265922798

化学品安全技术说明书

//s3-us-west-2.amazonaws.com/drugbank/msds/DB00208.pdf?1265922739

专利

食物相互作用

Take with a high fat meal. High fat meals will increase ticlopidine absorption.Take with food. Food can help ticlopidine-induced stomach upset.

药物相互作用

DB06605
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Apixaban.
DB01254
Dasatinib may increase the anticoagulant activities of Ticlopidine.
DB01586
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Ursodeoxycholic acid.
DB02123
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Glycochenodeoxycholic Acid.
DB02659
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Cholic Acid.
DB02691
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Glycocholic acid.
DB03619
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Deoxycholic acid.
DB04348
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Taurocholic acid.
DB05990
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Obeticholic acid.
DB06777
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Chenodeoxycholic acid.
DB08833
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Taurochenodeoxycholic acid.
DB08834
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Tauroursodeoxycholic acid.
DB08857
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Bamet-UD2.
DB11622
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Dehydrocholic acid.
DB11789
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Hyodeoxycholic Acid.
DB01296
Glucosamine may increase the antiplatelet activities of Ticlopidine.
DB00078
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Ibritumomab tiuxetan.
DB09053
The risk or severity of adverse effects can be increased when Ibrutinib is combined with Ticlopidine.
DB08935
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Obinutuzumab.
DB00806
Pentoxifylline may increase the antiplatelet activities of Ticlopidine.
DB06228
Ticlopidine may increase the anticoagulant activities of Rivaroxaban.
DB00932
Tipranavir may increase the antiplatelet activities of Ticlopidine.
DB00013
Ticlopidine may increase the anticoagulant activities of Urokinase.
DB00163
Vitamin E may increase the antiplatelet activities of Ticlopidine.
DB01166
The serum concentration of Cilostazol can be increased when it is combined with Ticlopidine.
DB00215
The serum concentration of Citalopram can be increased when it is combined with Ticlopidine.
DB04908
The serum concentration of Flibanserin can be increased when it is combined with Ticlopidine.
DB00758
The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Ticlopidine resulting in a loss in efficacy.
DB00201
The metabolism of Caffeine can be decreased when combined with Ticlopidine.
DB00277
The metabolism of Theophylline can be decreased when combined with Ticlopidine.
DB00651
The metabolism of Dyphylline can be decreased when combined with Ticlopidine.
DB01033
The metabolism of Mercaptopurine can be decreased when combined with Ticlopidine.
DB01223
The metabolism of Aminophylline can be decreased when combined with Ticlopidine.
DB01303
The metabolism of Oxtriphylline can be decreased when combined with Ticlopidine.
DB01412
The metabolism of Theobromine can be decreased when combined with Ticlopidine.
DB01482
The metabolism of Fenethylline can be decreased when combined with Ticlopidine.
DB01667
The metabolism of 8-azaguanine can be decreased when combined with Ticlopidine.
DB01978
The metabolism of 7,9-Dimethylguanine can be decreased when combined with Ticlopidine.
DB02134
The metabolism of Xanthine can be decreased when combined with Ticlopidine.
DB02245
The metabolism of 7-Deazaguanine can be decreased when combined with Ticlopidine.
DB02377
The metabolism of Guanine can be decreased when combined with Ticlopidine.
DB02489
The metabolism of 9-Methylguanine can be decreased when combined with Ticlopidine.
DB02568
The metabolism of Peldesine can be decreased when combined with Ticlopidine.
DB04076
The metabolism of Hypoxanthine can be decreased when combined with Ticlopidine.
DB04356
The metabolism of 9-Deazaguanine can be decreased when combined with Ticlopidine.
DB06479
The metabolism of Propentofylline can be decreased when combined with Ticlopidine.
DB06575
The metabolism of Valomaciclovir can be decreased when combined with Ticlopidine.
DB07954
The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Ticlopidine.
DB08844
The metabolism of Uric acid can be decreased when combined with Ticlopidine.
DB09273
The metabolism of Doxofylline can be decreased when combined with Ticlopidine.
DB11919
The metabolism of 6-O-benzylguanine can be decreased when combined with Ticlopidine.
DB12406
The metabolism of Lisofylline can be decreased when combined with Ticlopidine.
DB12531
The metabolism of Lobucavir can be decreased when combined with Ticlopidine.
DB12926
The metabolism of Cafedrine can be decreased when combined with Ticlopidine.
DB12927
The metabolism of Theodrenaline can be decreased when combined with Ticlopidine.
DB13203
The metabolism of Bamifylline can be decreased when combined with Ticlopidine.
DB13449
The metabolism of Proxyphylline can be decreased when combined with Ticlopidine.
DB13573
The metabolism of Acefylline can be decreased when combined with Ticlopidine.
DB13592
The metabolism of Etamiphylline can be decreased when combined with Ticlopidine.
DB13634
The metabolism of Pentifylline can be decreased when combined with Ticlopidine.
DB13812
The metabolism of Bufylline can be decreased when combined with Ticlopidine.
DB14018
The metabolism of Bromotheophylline can be decreased when combined with Ticlopidine.
DB14029
The metabolism of Furafylline can be decreased when combined with Ticlopidine.
DB14132
The metabolism of 8-chlorotheophylline can be decreased when combined with Ticlopidine.
DB15122
The metabolism of PCS-499 can be decreased when combined with Ticlopidine.
DB00315
The metabolism of Zolmitriptan can be decreased when combined with Ticlopidine.
DB00289
The metabolism of Atomoxetine can be decreased when combined with Ticlopidine.
DB00686
The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Ticlopidine.
DB09211
Limaprost may increase the antiplatelet activities of Ticlopidine.
DB11133
Omega-3 fatty acids may increase the antiplatelet activities of Ticlopidine.
DB00081
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Tositumomab.
DB00001
The risk or severity of bleeding can be increased when Ticlopidine is combined with Lepirudin.
DB00006
The risk or severity of bleeding can be increased when Ticlopidine is combined with Bivalirudin.
DB00009
The risk or severity of bleeding can be increased when Ticlopidine is combined with Alteplase.
DB00015
The risk or severity of bleeding can be increased when Ticlopidine is combined with Reteplase.
DB00029
The risk or severity of bleeding can be increased when Ticlopidine is combined with Anistreplase.
DB00031
The risk or severity of bleeding can be increased when Ticlopidine is combined with Tenecteplase.
DB00054
The risk or severity of bleeding can be increased when Ticlopidine is combined with Abciximab.
DB00055
The risk or severity of bleeding can be increased when Ticlopidine is combined with Drotrecogin alfa.
DB00086
The risk or severity of bleeding can be increased when Ticlopidine is combined with Streptokinase.
DB00266
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dicoumarol.
DB00278
The risk or severity of bleeding can be increased when Ticlopidine is combined with Argatroban.
DB00407
The risk or severity of bleeding can be increased when Ticlopidine is combined with Ardeparin.
DB00498
The risk or severity of bleeding can be increased when Ticlopidine is combined with Phenindione.
DB00569
The risk or severity of bleeding can be increased when Ticlopidine is combined with Fondaparinux.
DB00682
The risk or severity of bleeding can be increased when Ticlopidine is combined with Warfarin.
DB00946
The risk or severity of bleeding can be increased when Ticlopidine is combined with Phenprocoumon.
DB00975
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dipyridamole.
DB01088
The risk or severity of bleeding can be increased when Ticlopidine is combined with Iloprost.
DB01109
The risk or severity of bleeding can be increased when Ticlopidine is combined with Heparin.
DB01225
The risk or severity of bleeding can be increased when Ticlopidine is combined with Enoxaparin.
DB01240
The risk or severity of bleeding can be increased when Ticlopidine is combined with Epoprostenol.
DB01418
The risk or severity of bleeding can be increased when Ticlopidine is combined with Acenocoumarol.
DB03410
The risk or severity of bleeding can be increased when Ticlopidine is combined with 4-hydroxycoumarin.
DB04665
The risk or severity of bleeding can be increased when Ticlopidine is combined with Coumarin.
DB04898
The risk or severity of bleeding can be increased when Ticlopidine is combined with Ximelagatran.
DB04925
The risk or severity of bleeding can be increased when Ticlopidine is combined with Desmoteplase.
DB04932
The risk or severity of bleeding can be increased when Ticlopidine is combined with Defibrotide.
DB05099
The risk or severity of bleeding can be increased when Ticlopidine is combined with Ancrod.
DB05229
The risk or severity of bleeding can be increased when Ticlopidine is combined with Beraprost.
DB05254
The risk or severity of bleeding can be increased when Ticlopidine is combined with Fibrinolysin.
DB06209
The risk or severity of bleeding can be increased when Ticlopidine is combined with Prasugrel.
DB06271
The risk or severity of bleeding can be increased when Ticlopidine is combined with Sulodexide.
DB06294
The risk or severity of bleeding can be increased when Ticlopidine is combined with Semuloparin.
DB06406
The risk or severity of bleeding can be increased when Ticlopidine is combined with Idraparinux.
DB06441
The risk or severity of bleeding can be increased when Ticlopidine is combined with Cangrelor.
DB06543
The risk or severity of bleeding can be increased when Ticlopidine is combined with Astaxanthin.
DB06635
The risk or severity of bleeding can be increased when Ticlopidine is combined with Otamixaban.
DB06679
The risk or severity of bleeding can be increased when Ticlopidine is combined with Amediplase.
DB06754
The risk or severity of bleeding can be increased when Ticlopidine is combined with Danaparoid.
DB06779
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dalteparin.
DB06822
The risk or severity of bleeding can be increased when Ticlopidine is combined with Tinzaparin.
DB07767
The risk or severity of bleeding can be increased when Ticlopidine is combined with Ferulic acid.
DB08496
The risk or severity of bleeding can be increased when Ticlopidine is combined with (R)-warfarin.
DB08794
The risk or severity of bleeding can be increased when Ticlopidine is combined with Ethyl biscoumacetate.
DB08813
The risk or severity of bleeding can be increased when Ticlopidine is combined with Nadroparin.
DB08814
The risk or severity of bleeding can be increased when Ticlopidine is combined with Triflusal.
DB08816
The risk or severity of bleeding can be increased when Ticlopidine is combined with Ticagrelor.
DB08994
The risk or severity of bleeding can be increased when Ticlopidine is combined with Ditazole.
DB09030
The risk or severity of bleeding can be increased when Ticlopidine is combined with Vorapaxar.
DB09075
The risk or severity of bleeding can be increased when Ticlopidine is combined with Edoxaban.
DB09125
The risk or severity of bleeding can be increased when Ticlopidine is combined with Potassium citrate.
DB09154
The risk or severity of bleeding can be increased when Ticlopidine is combined with Sodium citrate.
DB09255
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dextran.
DB09258
The risk or severity of bleeding can be increased when Ticlopidine is combined with Bemiparin.
DB09260
The risk or severity of bleeding can be increased when Ticlopidine is combined with Parnaparin.
DB11095
The risk or severity of bleeding can be increased when Ticlopidine is combined with Desirudin.
DB11154
The risk or severity of bleeding can be increased when Ticlopidine is combined with Zinc citrate.
DB11166
The risk or severity of bleeding can be increased when Ticlopidine is combined with Antithrombin Alfa.
DB11312
The risk or severity of bleeding can be increased when Ticlopidine is combined with Protein C.
DB11598
The risk or severity of bleeding can be increased when Ticlopidine is combined with Antithrombin III human.
DB11984
The risk or severity of bleeding can be increased when Ticlopidine is combined with Letaxaban.
DB12289
The risk or severity of bleeding can be increased when Ticlopidine is combined with Darexaban.
DB12364
The risk or severity of bleeding can be increased when Ticlopidine is combined with Betrixaban.
DB12598
The risk or severity of bleeding can be increased when Ticlopidine is combined with Nafamostat.
DB12726
The risk or severity of bleeding can be increased when Ticlopidine is combined with Monteplase.
DB12831
The risk or severity of bleeding can be increased when Ticlopidine is combined with Gabexate.
DB13136
The risk or severity of bleeding can be increased when Ticlopidine is combined with Fluindione.
DB13149
The risk or severity of bleeding can be increased when Ticlopidine is combined with Protein S human.
DB13199
The risk or severity of bleeding can be increased when Ticlopidine is combined with Brinase.
DB13275
The risk or severity of bleeding can be increased when Ticlopidine is combined with Clorindione.
DB13347
The risk or severity of bleeding can be increased when Ticlopidine is combined with Diphenadione.
DB13451
The risk or severity of bleeding can be increased when Ticlopidine is combined with Tioclomarol.
DB13616
The risk or severity of bleeding can be increased when Ticlopidine is combined with Melagatran.
DB13646
The risk or severity of bleeding can be increased when Ticlopidine is combined with Saruplase.
DB14055
The risk or severity of bleeding can be increased when Ticlopidine is combined with (S)-Warfarin.
DB14094
The risk or severity of bleeding can be increased when Ticlopidine is combined with Tocopherylquinone.
DB14598
The risk or severity of bleeding can be increased when Ticlopidine is combined with Edetate calcium disodium anhydrous.
DB14726
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dabigatran.
DB13124
The risk or severity of bleeding can be increased when Ticlopidine is combined with Troxerutin.
DB00974
The risk or severity of bleeding can be increased when Ticlopidine is combined with Edetic acid.
DB09259
The risk or severity of bleeding can be increased when Ticlopidine is combined with Reviparin.
DB00374
Treprostinil may increase the antiplatelet activities of Ticlopidine.
DB00307
The metabolism of Ticlopidine can be increased when combined with Bexarotene.
DB00559
The metabolism of Ticlopidine can be increased when combined with Bosentan.
DB00607
The metabolism of Ticlopidine can be increased when combined with Nafcillin.
DB00745
The metabolism of Ticlopidine can be increased when combined with Modafinil.
DB06442
The metabolism of Ticlopidine can be increased when combined with Avasimibe.
DB14240
The metabolism of Ticlopidine can be increased when combined with Echinacea.
DB00648
The metabolism of Ticlopidine can be increased when combined with Mitotane.
DB01220
The metabolism of Ticlopidine can be increased when combined with Rifaximin.
DB01234
The metabolism of Ticlopidine can be increased when combined with Dexamethasone.
DB06595
The metabolism of Ticlopidine can be increased when combined with Midostaurin.
DB08899
The metabolism of Ticlopidine can be increased when combined with Enzalutamide.
DB09280
The metabolism of Ticlopidine can be increased when combined with Lumacaftor.
DB11753
The metabolism of Ticlopidine can be increased when combined with Rifamycin.
DB11901
The metabolism of Ticlopidine can be increased when combined with Apalutamide.
DB01045
The metabolism of Rifampicin can be increased when combined with Ticlopidine.
DB00564
The metabolism of Ticlopidine can be increased when combined with Carbamazepine.
DB00196
The metabolism of Ticlopidine can be decreased when combined with Fluconazole.
DB00270
The metabolism of Isradipine can be decreased when combined with Ticlopidine.
DB00537
The metabolism of Ciprofloxacin can be decreased when combined with Ticlopidine.
DB00951
The metabolism of Isoniazid can be decreased when combined with Ticlopidine.
DB00199
The metabolism of Ticlopidine can be decreased when combined with Erythromycin.
DB00343
The metabolism of Ticlopidine can be decreased when combined with Diltiazem.
DB01110
The metabolism of Ticlopidine can be decreased when combined with Miconazole.
DB01406
The metabolism of Ticlopidine can be decreased when combined with Danazol.
DB06290
The metabolism of Ticlopidine can be decreased when combined with Simeprevir.
DB06712
The metabolism of Ticlopidine can be decreased when combined with Nilvadipine.
DB08882
The metabolism of Ticlopidine can be decreased when combined with Linagliptin.
DB09048
The metabolism of Ticlopidine can be decreased when combined with Netupitant.
DB09227
The metabolism of Ticlopidine can be decreased when combined with Barnidipine.
DB09231
The metabolism of Ticlopidine can be decreased when combined with Benidipine.
DB14019
The metabolism of Ticlopidine can be decreased when combined with Fosnetupitant.
DB00246
The metabolism of Ticlopidine can be decreased when combined with Ziprasidone.
DB00227
The metabolism of Ticlopidine can be decreased when combined with Lovastatin.
DB00673
The metabolism of Ticlopidine can be decreased when combined with Aprepitant.
DB11633
The metabolism of Ticlopidine can be decreased when combined with Isavuconazole.
DB00763
The metabolism of Methimazole can be decreased when combined with Ticlopidine.
DB00976
The metabolism of Ticlopidine can be decreased when combined with Telithromycin.
DB01072
The metabolism of Ticlopidine can be decreased when combined with Atazanavir.
DB01149
The metabolism of Ticlopidine can be decreased when combined with Nefazodone.
DB01167
The metabolism of Ticlopidine can be decreased when combined with Itraconazole.
DB01183
The metabolism of Ticlopidine can be decreased when combined with Naloxone.
DB01211
The metabolism of Ticlopidine can be decreased when combined with Clarithromycin.
DB01263
The metabolism of Ticlopidine can be decreased when combined with Posaconazole.
DB02520
The metabolism of Ticlopidine can be decreased when combined with Ditiocarb.
DB05521
The metabolism of Ticlopidine can be decreased when combined with Telaprevir.
DB09065
The metabolism of Ticlopidine can be decreased when combined with Cobicistat.
DB09101
The metabolism of Ticlopidine can be decreased when combined with Elvitegravir.
DB09118
The metabolism of Ticlopidine can be decreased when combined with Stiripentol.
DB11730
The metabolism of Ticlopidine can be decreased when combined with Ribociclib.
DB11779
The metabolism of Ticlopidine can be decreased when combined with Danoprevir.
DB13179
The metabolism of Ticlopidine can be decreased when combined with Troleandomycin.
DB00696
The metabolism of Ergotamine can be decreased when combined with Ticlopidine.
DB00872
The metabolism of Conivaptan can be decreased when combined with Ticlopidine.
DB01232
The metabolism of Saquinavir can be decreased when combined with Ticlopidine.
DB01264
The metabolism of Darunavir can be decreased when combined with Ticlopidine.
DB08873
The metabolism of Boceprevir can be decreased when combined with Ticlopidine.
DB01601
The metabolism of Ticlopidine can be decreased when combined with Lopinavir.
DB06448
The metabolism of Ticlopidine can be decreased when combined with Lonafarnib.
DB00213
The metabolism of Pantoprazole can be decreased when combined with Ticlopidine.
DB00312
The metabolism of Pentobarbital can be decreased when combined with Ticlopidine.
DB00333
The metabolism of Methadone can be decreased when combined with Ticlopidine.
DB00338
The metabolism of Omeprazole can be decreased when combined with Ticlopidine.
DB00347
The metabolism of Trimethadione can be decreased when combined with Ticlopidine.
DB00395
The metabolism of Carisoprodol can be decreased when combined with Ticlopidine.
DB00396
The metabolism of Progesterone can be decreased when combined with Ticlopidine.
DB00448
The metabolism of Lansoprazole can be decreased when combined with Ticlopidine.
DB00474
The metabolism of Methohexital can be decreased when combined with Ticlopidine.
DB00518
The metabolism of Albendazole can be decreased when combined with Ticlopidine.
DB00582
The metabolism of Voriconazole can be decreased when combined with Ticlopidine.
DB00590
The metabolism of Doxazosin can be decreased when combined with Ticlopidine.
DB00599
The metabolism of Thiopental can be decreased when combined with Ticlopidine.
DB00736
The metabolism of Esomeprazole can be decreased when combined with Ticlopidine.
DB00794
The metabolism of Primidone can be decreased when combined with Ticlopidine.
DB00829
The metabolism of Diazepam can be decreased when combined with Ticlopidine.
DB00849
The metabolism of Methylphenobarbital can be decreased when combined with Ticlopidine.
DB00909
The metabolism of Zonisamide can be decreased when combined with Ticlopidine.
DB00980
The metabolism of Ramelteon can be decreased when combined with Ticlopidine.
DB01058
The metabolism of Praziquantel can be decreased when combined with Ticlopidine.
DB01129
The metabolism of Rabeprazole can be decreased when combined with Ticlopidine.
DB01131
The metabolism of Proguanil can be decreased when combined with Ticlopidine.
DB01259
The metabolism of Lapatinib can be decreased when combined with Ticlopidine.
DB01323
The metabolism of St. John's Wort can be decreased when combined with Ticlopidine.
DB01355
The metabolism of Hexobarbital can be decreased when combined with Ticlopidine.
DB01483
The metabolism of Barbital can be decreased when combined with Ticlopidine.
DB05246
The metabolism of Methsuximide can be decreased when combined with Ticlopidine.
DB05351
The metabolism of Dexlansoprazole can be decreased when combined with Ticlopidine.
DB06218
The metabolism of Lacosamide can be decreased when combined with Ticlopidine.
DB06414
The metabolism of Etravirine can be decreased when combined with Ticlopidine.
DB06626
The metabolism of Axitinib can be decreased when combined with Ticlopidine.
DB06697
The metabolism of Artemether can be decreased when combined with Ticlopidine.
DB06739
The metabolism of Seratrodast can be decreased when combined with Ticlopidine.
DB09068
The metabolism of Vortioxetine can be decreased when combined with Ticlopidine.
DB09166
The metabolism of Etizolam can be decreased when combined with Ticlopidine.
DB12130
The metabolism of Lorlatinib can be decreased when combined with Ticlopidine.
DB12245
The metabolism of Triclabendazole can be decreased when combined with Ticlopidine.
DB12474
The metabolism of Lynestrenol can be decreased when combined with Ticlopidine.
DB13762
The metabolism of Dexrabeprazole can be decreased when combined with Ticlopidine.
DB00624
The metabolism of Testosterone can be decreased when combined with Ticlopidine.
DB00783
The metabolism of Estradiol can be decreased when combined with Ticlopidine.
DB00425
The metabolism of Zolpidem can be decreased when combined with Ticlopidine.
DB01016
The metabolism of Glyburide can be decreased when combined with Ticlopidine.
DB00983
The metabolism of Formoterol can be decreased when combined with Ticlopidine.
DB04861
The metabolism of Nebivolol can be decreased when combined with Ticlopidine.
DB00598
The metabolism of Ticlopidine can be decreased when combined with Labetalol.
DB12500
The metabolism of Fedratinib can be decreased when combined with Ticlopidine.
DB14975
The metabolism of Voxelotor can be decreased when combined with Ticlopidine.
DB01142
The metabolism of Doxepin can be decreased when combined with Ticlopidine.
DB11689
The metabolism of Selumetinib can be decreased when combined with Ticlopidine.
DB11823
The metabolism of Esketamine can be decreased when combined with Ticlopidine.
DB00313
The metabolism of Valproic acid can be decreased when combined with Ticlopidine.
DB00468
The metabolism of Quinine can be decreased when combined with Ticlopidine.
DB00476
The metabolism of Ticlopidine can be decreased when combined with Duloxetine.
DB12693
The metabolism of Ticlopidine can be decreased when combined with Ritanserin.
DB00285
The metabolism of Ticlopidine can be decreased when combined with Venlafaxine.
DB00752
The metabolism of Ticlopidine can be decreased when combined with Tranylcypromine.
DB00349
The metabolism of Clobazam can be decreased when combined with Ticlopidine.
DB01074
The metabolism of Perhexiline can be decreased when combined with Ticlopidine.
DB11586
The metabolism of Asunaprevir can be decreased when combined with Ticlopidine.
DB00458
The metabolism of Imipramine can be decreased when combined with Ticlopidine.
DB01151
The metabolism of Desipramine can be decreased when combined with Ticlopidine.
DB09167
The metabolism of Dosulepin can be decreased when combined with Ticlopidine.
DB00482
The metabolism of Ticlopidine can be decreased when combined with Celecoxib.
DB00176
The metabolism of Ticlopidine can be decreased when combined with Fluvoxamine.
DB00264
The metabolism of Metoprolol can be decreased when combined with Ticlopidine.
DB00363
The metabolism of Clozapine can be decreased when combined with Ticlopidine.
DB00477
The metabolism of Chlorpromazine can be decreased when combined with Ticlopidine.
DB00501
The metabolism of Cimetidine can be decreased when combined with Ticlopidine.
DB00608
The metabolism of Chloroquine can be decreased when combined with Ticlopidine.
DB00622
The metabolism of Ticlopidine can be decreased when combined with Nicardipine.
DB02703
The metabolism of Ticlopidine can be decreased when combined with Fusidic acid.
DB00705
The metabolism of Ticlopidine can be decreased when combined with Delavirdine.
DB01026
The metabolism of Ticlopidine can be decreased when combined with Ketoconazole.
DB04868
The metabolism of Ticlopidine can be decreased when combined with Nilotinib.
DB00169
The metabolism of Ticlopidine can be decreased when combined with Cholecalciferol.
DB01079
The metabolism of Ticlopidine can be decreased when combined with Tegaserod.
DB05812
The metabolism of Ticlopidine can be decreased when combined with Abiraterone.
DB06603
The metabolism of Ticlopidine can be decreased when combined with Panobinostat.
DB06684
The metabolism of Ticlopidine can be decreased when combined with Vilazodone.
DB06729
The metabolism of Ticlopidine can be decreased when combined with Sulfaphenazole.
DB06819
The metabolism of Ticlopidine can be decreased when combined with Phenylbutyric acid.
DB09238
The metabolism of Ticlopidine can be decreased when combined with Manidipine.
DB09291
The metabolism of Ticlopidine can be decreased when combined with Rolapitant.
DB13174
The metabolism of Ticlopidine can be decreased when combined with Rhein.
DB00857
The metabolism of Ticlopidine can be decreased when combined with Terbinafine.
DB06708
The metabolism of Ticlopidine can be decreased when combined with Lumefantrine.
DB00091
The metabolism of Cyclosporine can be decreased when combined with Ticlopidine.
DB00342
The metabolism of Terfenadine can be decreased when combined with Ticlopidine.
DB00496
The metabolism of Darifenacin can be decreased when combined with Ticlopidine.
DB01087
The metabolism of Primaquine can be decreased when combined with Ticlopidine.
DB12332
The metabolism of Rucaparib can be decreased when combined with Ticlopidine.
DB04871
The metabolism of Lorcaserin can be decreased when combined with Ticlopidine.
DB08893
The metabolism of Mirabegron can be decreased when combined with Ticlopidine.
DB15982
The metabolism of Ticlopidine can be decreased when combined with Berotralstat.
DB00679
The metabolism of Ticlopidine can be decreased when combined with Thioridazine.
DB00715
The metabolism of Ticlopidine can be decreased when combined with Paroxetine.
DB01012
The metabolism of Ticlopidine can be decreased when combined with Cinacalcet.
DB01173
The metabolism of Ticlopidine can be decreased when combined with Orphenadrine.
DB01182
The metabolism of Ticlopidine can be decreased when combined with Propafenone.
DB01218
The metabolism of Ticlopidine can be decreased when combined with Halofantrine.
DB01403
The metabolism of Ticlopidine can be decreased when combined with Methotrimeprazine.
DB08909
The metabolism of Ticlopidine can be decreased when combined with Glycerol phenylbutyrate.
DB00908
The metabolism of Ticlopidine can be decreased when combined with Quinidine.
DB00063
Eptifibatide may increase the antiplatelet activities of Ticlopidine.
DB00775
Ticlopidine may increase the antiplatelet activities of Tirofiban.
DB01138
Ticlopidine may increase the antiplatelet activities of Sulfinpyrazone.
DB01207
Ticlopidine may increase the antiplatelet activities of Ridogrel.
DB02709
Ticlopidine may increase the antiplatelet activities of Resveratrol.
DB04905
Ticlopidine may increase the antiplatelet activities of Tesmilifene.
DB05266
Ticlopidine may increase the antiplatelet activities of Ibudilast.
DB05767
Ticlopidine may increase the antiplatelet activities of Andrographolide.
DB06081
Ticlopidine may increase the antiplatelet activities of Caplacizumab.
DB07615
Ticlopidine may increase the antiplatelet activities of Tranilast.
DB08887
Ticlopidine may increase the antiplatelet activities of Icosapent ethyl.
DB09283
Ticlopidine may increase the antiplatelet activities of Trapidil.
DB12092
Ticlopidine may increase the antiplatelet activities of Naftopidil.
DB12163
Ticlopidine may increase the antiplatelet activities of Sarpogrelate.
DB12321
Ticlopidine may increase the antiplatelet activities of Ifetroban.
DB12465
Ticlopidine may increase the antiplatelet activities of Ketanserin.
DB12749
Ticlopidine may increase the antiplatelet activities of Butylphthalide.
DB12771
Ticlopidine may increase the antiplatelet activities of Hydroxytyrosol.
DB13036
Ticlopidine may increase the antiplatelet activities of Ramatroban.
DB13327
Ticlopidine may increase the antiplatelet activities of Picotamide.
DB13367
Ticlopidine may increase the antiplatelet activities of Cloricromen.
DB13400
Ticlopidine may increase the antiplatelet activities of Linsidomine.
DB13510
Ticlopidine may increase the antiplatelet activities of Buflomedil.
DB13929
Ticlopidine may increase the antiplatelet activities of Relcovaptan.
DB00233
The risk or severity of bleeding can be increased when Ticlopidine is combined with Aminosalicylic acid.
DB01294
The risk or severity of bleeding can be increased when Ticlopidine is combined with Bismuth subsalicylate.
DB06251
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dersalazine.
DB06807
The risk or severity of bleeding can be increased when Ticlopidine is combined with Phenyl aminosalicylate.
DB09543
The risk or severity of bleeding can be increased when Ticlopidine is combined with Methyl salicylate.
DB13509
The risk or severity of bleeding can be increased when Ticlopidine is combined with Aloxiprin.
DB14006
The risk or severity of bleeding can be increased when Ticlopidine is combined with Choline salicylate.
DB14026
The risk or severity of bleeding can be increased when Ticlopidine is combined with Thiosalicylic acid.
DB06695
Ticlopidine may increase the anticoagulant activities of Dabigatran etexilate.
DB00008
The risk or severity of bleeding can be increased when Ticlopidine is combined with Peginterferon alfa-2a.
DB00011
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon alfa-n1.
DB00018
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon alfa-n3.
DB00022
The risk or severity of bleeding can be increased when Ticlopidine is combined with Peginterferon alfa-2b.
DB00033
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon gamma-1b.
DB00034
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon alfa-2a, Recombinant.
DB00056
The risk or severity of bleeding can be increased when Ticlopidine is combined with Gemtuzumab ozogamicin.
DB00068
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon beta-1b.
DB00069
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon alfacon-1.
DB00073
The risk or severity of bleeding can be increased when Ticlopidine is combined with Rituximab.
DB00087
The risk or severity of bleeding can be increased when Ticlopidine is combined with Alemtuzumab.
DB00105
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon alfa-2b.
DB00120
The risk or severity of bleeding can be increased when Ticlopidine is combined with Phenylalanine.
DB00242
The risk or severity of bleeding can be increased when Ticlopidine is combined with Cladribine.
DB00276
The risk or severity of bleeding can be increased when Ticlopidine is combined with Amsacrine.
DB00291
The risk or severity of bleeding can be increased when Ticlopidine is combined with Chlorambucil.
DB00293
The risk or severity of bleeding can be increased when Ticlopidine is combined with Raltitrexed.
DB00305
The risk or severity of bleeding can be increased when Ticlopidine is combined with Mitomycin.
DB00352
The risk or severity of bleeding can be increased when Ticlopidine is combined with Tioguanine.
DB00428
The risk or severity of bleeding can be increased when Ticlopidine is combined with Streptozocin.
DB00445
The risk or severity of bleeding can be increased when Ticlopidine is combined with Epirubicin.
DB00488
The risk or severity of bleeding can be increased when Ticlopidine is combined with Altretamine.
DB00526
The risk or severity of bleeding can be increased when Ticlopidine is combined with Oxaliplatin.
DB00550
The risk or severity of bleeding can be increased when Ticlopidine is combined with Propylthiouracil.
DB00859
The risk or severity of bleeding can be increased when Ticlopidine is combined with Penicillamine.
DB00888
The risk or severity of bleeding can be increased when Ticlopidine is combined with Mechlorethamine.
DB00970
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dactinomycin.
DB01041
The risk or severity of bleeding can be increased when Ticlopidine is combined with Thalidomide.
DB01042
The risk or severity of bleeding can be increased when Ticlopidine is combined with Melphalan.
DB01073
The risk or severity of bleeding can be increased when Ticlopidine is combined with Fludarabine.
DB01262
The risk or severity of bleeding can be increased when Ticlopidine is combined with Decitabine.
DB01280
The risk or severity of bleeding can be increased when Ticlopidine is combined with Nelarabine.
DB02546
The risk or severity of bleeding can be increased when Ticlopidine is combined with Vorinostat.
DB05258
The risk or severity of bleeding can be increased when Ticlopidine is combined with Interferon alfa.
DB05472
The risk or severity of bleeding can be increased when Ticlopidine is combined with Human interferon omega-1.
DB08871
The risk or severity of bleeding can be increased when Ticlopidine is combined with Eribulin.
DB08889
The risk or severity of bleeding can be increased when Ticlopidine is combined with Carfilzomib.
DB09042
The risk or severity of bleeding can be increased when Ticlopidine is combined with Tedizolid phosphate.
DB09052
The risk or severity of bleeding can be increased when Ticlopidine is combined with Blinatumomab.
DB09077
The risk or severity of bleeding can be increased when Ticlopidine is combined with Dinutuximab.
DB09122
The risk or severity of bleeding can be increased when Ticlopidine is combined with Peginterferon beta-1a.
DB12814
The risk or severity of bleeding can be increased when Ticlopidine is combined with Cepeginterferon alfa-2B.
DB08895
The risk or severity of bleeding can be increased when Ticlopidine is combined with Tofacitinib.
DB01206
The risk or severity of bleeding can be increased when Ticlopidine is combined with Lomustine.
DB00987
The risk or severity of bleeding can be increased when Ticlopidine is combined with Cytarabine.
DB05015
The risk or severity of bleeding can be increased when Ticlopidine is combined with Belinostat.
DB11642
The serum concentration of Ticlopidine can be decreased when it is combined with Pitolisant.
DB01238
The metabolism of Aripiprazole can be decreased when combined with Ticlopidine.
DB14185
The metabolism of Aripiprazole lauroxil can be decreased when combined with Ticlopidine.
DB04832
The risk or severity of hemorrhage can be increased when Zimelidine is combined with Ticlopidine.
DB04884
The risk or severity of hemorrhage can be increased when Dapoxetine is combined with Ticlopidine.
DB04896
The risk or severity of hemorrhage can be increased when Milnacipran is combined with Ticlopidine.
DB06700
The risk or severity of hemorrhage can be increased when Desvenlafaxine is combined with Ticlopidine.
DB06731
The risk or severity of hemorrhage can be increased when Seproxetine is combined with Ticlopidine.
DB08953
The risk or severity of hemorrhage can be increased when Indalpine is combined with Ticlopidine.
DB13233
The risk or severity of hemorrhage can be increased when Alaproclate is combined with Ticlopidine.
DB01105
Sibutramine may increase the antiplatelet activities of Ticlopidine.
DB08918
Levomilnacipran may increase the antiplatelet activities of Ticlopidine.
DB00295
The therapeutic efficacy of Ticlopidine can be decreased when used in combination with Morphine.
DB00229
Cefotiam may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00267
Cefmenoxime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00274
Cefmetazole may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00282
Pamidronic acid may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00300
Tenofovir disoproxil may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00369
Cidofovir may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00430
Cefpiramide may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00438
Ceftazidime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00447
Loracarbef may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00456
Cefalotin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00493
Cefotaxime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00529
Foscarnet may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00567
Cephalexin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00577
Valaciclovir may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00626
Bacitracin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00681
Amphotericin B may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00689
Cephaloglycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00718
Adefovir dipivoxil may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00738
Pentamidine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00742
Mannitol may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00787
Acyclovir may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00833
Cefaclor may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00903
Etacrynic acid may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00923
Ceforanide may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00958
Carboplatin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00999
Hydrochlorothiazide may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01066
Cefditoren may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01111
Colistimethate may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01112
Cefuroxime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01139
Cefapirin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01140
Cefadroxil may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01150
Cefprozil may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01212
Ceftriaxone may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01326
Cefamandole may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01327
Cefazolin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01328
Cefonicid may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01329
Cefoperazone may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01330
Cefotetan may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01331
Cefoxitin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01332
Ceftizoxime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01333
Cefradine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01413
Cefepime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01414
Cefacetrile may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01415
Ceftibuten may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01416
Cefpodoxime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB02247
Hydrolyzed Cephalothin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB03450
Cephalothin Group may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB04570
Latamoxef may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB04918
Ceftobiprole may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB06590
Ceftaroline fosamil may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB09008
Cefaloridine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB09062
Cefminox may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB09299
Tenofovir alafenamide may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB11367
Cefroxadine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB11935
Flomoxef may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB12151
Brincidofovir may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13266
Cefatrizine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13461
Cefcapene may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13470
Cefodizime may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13499
Cefsulodin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13504
Cefetamet may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13638
Cefbuperazone may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13667
Cefozopran may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13682
Cefpirome may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13778
Cefazedone may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13821
Ceftezole may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13868
Adefovir may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB14126
Tenofovir may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB14713
Inotersen may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01438
Phenazopyridine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01356
Lithium cation may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB14507
Lithium citrate may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00452
Framycetin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01421
Paromomycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB04263
Geneticin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB04626
Apramycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB04808
Neamine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB08437
Puromycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB11512
Dihydrostreptomycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB11520
Hygromycin B may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00007
Leuprolide may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00014
Goserelin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00017
Salmon calcitonin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00035
Desmopressin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00080
Daptomycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00115
Cyanocobalamin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00158
Folic acid may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00165
Pyridoxine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00181
Baclofen may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00190
Carbidopa may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00198
Oseltamivir may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00200
Hydroxocobalamin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00206
Reserpine may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00225
Ticlopidine may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
DB00230
Ticlopidine may decrease the excretion rate of Pregabalin which could result in a higher serum level.
DB00235
Ticlopidine may decrease the excretion rate of Milrinone which could result in a higher serum level.
DB00237
Ticlopidine may decrease the excretion rate of Butabarbital which could result in a higher serum level.
DB00271
Ticlopidine may decrease the excretion rate of Diatrizoate which could result in a higher serum level.
DB00279
Ticlopidine may decrease the excretion rate of Liothyronine which could result in a higher serum level.
DB00284
Ticlopidine may decrease the excretion rate of Acarbose which could result in a higher serum level.
DB00290
Ticlopidine may decrease the excretion rate of Bleomycin which could result in a higher serum level.
DB00292
Ticlopidine may decrease the excretion rate of Etomidate which could result in a higher serum level.
DB00294
Ticlopidine may decrease the excretion rate of Etonogestrel which could result in a higher serum level.
DB00303
Ticlopidine may decrease the excretion rate of Ertapenem which could result in a higher serum level.
DB00308
Ticlopidine may decrease the excretion rate of Ibutilide which could result in a higher serum level.
DB00319
Ticlopidine may decrease the excretion rate of Piperacillin which could result in a higher serum level.
DB00322
Ticlopidine may decrease the excretion rate of Floxuridine which could result in a higher serum level.
DB00323
Ticlopidine may decrease the excretion rate of Tolcapone which could result in a higher serum level.
DB00325
Ticlopidine may decrease the excretion rate of Nitroprusside which could result in a higher serum level.
DB00327
Ticlopidine may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
DB00330
Ticlopidine may decrease the excretion rate of Ethambutol which could result in a higher serum level.
DB00331
Ticlopidine may decrease the excretion rate of Metformin which could result in a higher serum level.
DB00339
Ticlopidine may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
DB00341
Ticlopidine may decrease the excretion rate of Cetirizine which could result in a higher serum level.
DB00351
Ticlopidine may decrease the excretion rate of Megestrol acetate which could result in a higher serum level.
DB00355
Ticlopidine may decrease the excretion rate of Aztreonam which could result in a higher serum level.
DB00359
Ticlopidine may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
DB00364
Ticlopidine may decrease the excretion rate of Sucralfate which could result in a higher serum level.
DB00372
Ticlopidine may decrease the excretion rate of Thiethylperazine which could result in a higher serum level.
DB00380
Ticlopidine may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
DB00402
Ticlopidine may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
DB00413
Ticlopidine may decrease the excretion rate of Pramipexole which could result in a higher serum level.
DB00415
Ticlopidine may decrease the excretion rate of Ampicillin which could result in a higher serum level.
DB00422
Ticlopidine may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
DB00432
Ticlopidine may decrease the excretion rate of Trifluridine which could result in a higher serum level.
DB00437
Ticlopidine may decrease the excretion rate of Allopurinol which could result in a higher serum level.
DB00440
Ticlopidine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
DB00441
Ticlopidine may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
DB00480
Ticlopidine may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
DB00492
Ticlopidine may decrease the excretion rate of Fosinopril which could result in a higher serum level.
DB00535
Ticlopidine may decrease the excretion rate of Cefdinir which could result in a higher serum level.
DB00548
Ticlopidine may decrease the excretion rate of Azelaic acid which could result in a higher serum level.
DB00553
Ticlopidine may decrease the excretion rate of Methoxsalen which could result in a higher serum level.
DB00555
Ticlopidine may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
DB00558
Ticlopidine may decrease the excretion rate of Zanamivir which could result in a higher serum level.
DB00583
Ticlopidine may decrease the excretion rate of Levocarnitine which could result in a higher serum level.
DB00597
Ticlopidine may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
DB00612
Ticlopidine may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
DB00628
Ticlopidine may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
DB00631
Ticlopidine may decrease the excretion rate of Clofarabine which could result in a higher serum level.
DB00635
Ticlopidine may decrease the excretion rate of Prednisone which could result in a higher serum level.
DB00657
Ticlopidine may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
DB00660
Ticlopidine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
DB00665
Ticlopidine may decrease the excretion rate of Nilutamide which could result in a higher serum level.
DB00669
Ticlopidine may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
DB00672
Ticlopidine may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
DB00688
Ticlopidine may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
DB00690
Ticlopidine may decrease the excretion rate of Flurazepam which could result in a higher serum level.
DB00692
Ticlopidine may decrease the excretion rate of Phentolamine which could result in a higher serum level.
DB00698
Ticlopidine may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
DB00709
Ticlopidine may decrease the excretion rate of Lamivudine which could result in a higher serum level.
DB00713
Ticlopidine may decrease the excretion rate of Oxacillin which could result in a higher serum level.
DB00716
Ticlopidine may decrease the excretion rate of Nedocromil which could result in a higher serum level.
DB00722
Ticlopidine may decrease the excretion rate of Lisinopril which could result in a higher serum level.
DB00733
Ticlopidine may decrease the excretion rate of Pralidoxime which could result in a higher serum level.
DB00743
Ticlopidine may decrease the excretion rate of Gadobenic acid which could result in a higher serum level.
DB00760
Ticlopidine may decrease the excretion rate of Meropenem which could result in a higher serum level.
DB00761
Ticlopidine may decrease the excretion rate of Potassium chloride which could result in a higher serum level.
DB00782
Ticlopidine may decrease the excretion rate of Propantheline which could result in a higher serum level.
DB00789
Ticlopidine may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
DB00790
Ticlopidine may decrease the excretion rate of Perindopril which could result in a higher serum level.
DB00800
Ticlopidine may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
DB00804
Ticlopidine may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
DB00811
Ticlopidine may decrease the excretion rate of Ribavirin which could result in a higher serum level.
DB00828
Ticlopidine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
DB00839
Ticlopidine may decrease the excretion rate of Tolazamide which could result in a higher serum level.
DB00841
Ticlopidine may decrease the excretion rate of Dobutamine which could result in a higher serum level.
DB00842
Ticlopidine may decrease the excretion rate of Oxazepam which could result in a higher serum level.
DB00853
Ticlopidine may decrease the excretion rate of Temozolomide which could result in a higher serum level.
DB00871
Ticlopidine may decrease the excretion rate of Terbutaline which could result in a higher serum level.
DB00894
Ticlopidine may decrease the excretion rate of Testolactone which could result in a higher serum level.
DB00900
Ticlopidine may decrease the excretion rate of Didanosine which could result in a higher serum level.
DB00911
Ticlopidine may decrease the excretion rate of Tinidazole which could result in a higher serum level.
DB00915
Ticlopidine may decrease the excretion rate of Amantadine which could result in a higher serum level.
DB00928
Ticlopidine may decrease the excretion rate of Azacitidine which could result in a higher serum level.
DB00953
Ticlopidine may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
DB00961
Ticlopidine may decrease the excretion rate of Mepivacaine which could result in a higher serum level.
DB00962
Ticlopidine may decrease the excretion rate of Zaleplon which could result in a higher serum level.
DB00968
Ticlopidine may decrease the excretion rate of Methyldopa which could result in a higher serum level.
DB00988
Ticlopidine may decrease the excretion rate of Dopamine which could result in a higher serum level.
DB00995
Ticlopidine may decrease the excretion rate of Auranofin which could result in a higher serum level.
DB01001
Ticlopidine may decrease the excretion rate of Salbutamol which could result in a higher serum level.
DB01004
Ticlopidine may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
DB01010
Ticlopidine may decrease the excretion rate of Edrophonium which could result in a higher serum level.
DB01018
Ticlopidine may decrease the excretion rate of Guanfacine which could result in a higher serum level.
DB01020
Ticlopidine may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level.
DB01022
Ticlopidine may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
DB01024
Ticlopidine may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
DB01043
Ticlopidine may decrease the excretion rate of Memantine which could result in a higher serum level.
DB01046
Ticlopidine may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
DB01048
Ticlopidine may decrease the excretion rate of Abacavir which could result in a higher serum level.
DB01060
Ticlopidine may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
DB01067
Ticlopidine may decrease the excretion rate of Glipizide which could result in a higher serum level.
DB01068
Ticlopidine may decrease the excretion rate of Clonazepam which could result in a higher serum level.
DB01099
Ticlopidine may decrease the excretion rate of Flucytosine which could result in a higher serum level.
DB01124
Ticlopidine may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
DB01133
Ticlopidine may decrease the excretion rate of Tiludronic acid which could result in a higher serum level.
DB01135
Ticlopidine may decrease the excretion rate of Doxacurium which could result in a higher serum level.
DB01137
Ticlopidine may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
DB01148
Ticlopidine may decrease the excretion rate of Flavoxate which could result in a higher serum level.
DB01157
Ticlopidine may decrease the excretion rate of Trimetrexate which could result in a higher serum level.
DB01169
Ticlopidine may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
DB01170
Ticlopidine may decrease the excretion rate of Guanethidine which could result in a higher serum level.
DB01205
Ticlopidine may decrease the excretion rate of Flumazenil which could result in a higher serum level.
DB01213
Ticlopidine may decrease the excretion rate of Fomepizole which could result in a higher serum level.
DB01215
Ticlopidine may decrease the excretion rate of Estazolam which could result in a higher serum level.
DB01241
Ticlopidine may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
DB01249
Ticlopidine may decrease the excretion rate of Iodixanol which could result in a higher serum level.
DB01261
Ticlopidine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
DB01273
Ticlopidine may decrease the excretion rate of Varenicline which could result in a higher serum level.
DB01420
Ticlopidine may decrease the excretion rate of Testosterone propionate which could result in a higher serum level.
DB01427
Ticlopidine may decrease the excretion rate of Amrinone which could result in a higher serum level.
DB01428
Ticlopidine may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
DB01550
Ticlopidine may decrease the excretion rate of Fenproporex which could result in a higher serum level.
DB01563
Ticlopidine may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
DB01610
Ticlopidine may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
DB01638
Ticlopidine may decrease the excretion rate of Sorbitol which could result in a higher serum level.
DB04895
Ticlopidine may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
DB04953
Ticlopidine may decrease the excretion rate of Ezogabine which could result in a higher serum level.
DB05018
Ticlopidine may decrease the excretion rate of Migalastat which could result in a higher serum level.
DB06154
Ticlopidine may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level.
DB06186
Ticlopidine may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
DB06196
Ticlopidine may decrease the excretion rate of Icatibant which could result in a higher serum level.
DB06211
Ticlopidine may decrease the excretion rate of Doripenem which could result in a higher serum level.
DB06230
Ticlopidine may decrease the excretion rate of Nalmefene which could result in a higher serum level.
DB06262
Ticlopidine may decrease the excretion rate of Droxidopa which could result in a higher serum level.
DB06282
Ticlopidine may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
DB06335
Ticlopidine may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
DB06402
Ticlopidine may decrease the excretion rate of Telavancin which could result in a higher serum level.
DB06623
Ticlopidine may decrease the excretion rate of Flupirtine which could result in a higher serum level.
DB06637
Ticlopidine may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
DB06705
Ticlopidine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
DB06767
Ticlopidine may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
DB06782
Ticlopidine may decrease the excretion rate of Dimercaprol which could result in a higher serum level.
DB06796
Ticlopidine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
DB06800
Ticlopidine may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
DB06809
Ticlopidine may decrease the excretion rate of Plerixafor which could result in a higher serum level.
DB06813
Ticlopidine may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
DB06823
Ticlopidine may decrease the excretion rate of Tiopronin which could result in a higher serum level.
DB06824
Ticlopidine may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level.
DB08824
Ticlopidine may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
DB08826
Ticlopidine may decrease the excretion rate of Deferiprone which could result in a higher serum level.
DB08840
Ticlopidine may decrease the excretion rate of N-methylnicotinamide which could result in a higher serum level.
DB08872
Ticlopidine may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level.
DB08894
Ticlopidine may decrease the excretion rate of Peginesatide which could result in a higher serum level.
DB08897
Ticlopidine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
DB08900
Ticlopidine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
DB08932
Ticlopidine may decrease the excretion rate of Macitentan which could result in a higher serum level.
DB08934
Ticlopidine may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
DB09027
Ticlopidine may decrease the excretion rate of Ledipasvir which could result in a higher serum level.
DB09050
Ticlopidine may decrease the excretion rate of Ceftolozane which could result in a higher serum level.
DB09066
Ticlopidine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level.
DB09081
Ticlopidine may decrease the excretion rate of Idebenone which could result in a higher serum level.
DB09082
Ticlopidine may decrease the excretion rate of Vilanterol which could result in a higher serum level.
DB09089
Ticlopidine may decrease the excretion rate of Trimebutine which could result in a higher serum level.
DB09091
Ticlopidine may decrease the excretion rate of Tixocortol which could result in a higher serum level.
DB09103
Ticlopidine may decrease the excretion rate of Ancestim which could result in a higher serum level.
DB09104
Ticlopidine may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
DB09106
Ticlopidine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
DB09111
Ticlopidine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
DB09121
Ticlopidine may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.
DB09123
Ticlopidine may decrease the excretion rate of Dienogest which could result in a higher serum level.
DB09129
Ticlopidine may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
DB09132
Ticlopidine may decrease the excretion rate of Gadoteric acid which could result in a higher serum level.
DB09133
Ticlopidine may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.
DB09134
Ticlopidine may decrease the excretion rate of Ioversol which could result in a higher serum level.
DB09135
Ticlopidine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
DB09136
Ticlopidine may decrease the excretion rate of Isosulfan blue which could result in a higher serum level.
DB09137
Ticlopidine may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
DB09139
Ticlopidine may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level.
DB09148
Ticlopidine may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level.
DB09149
Ticlopidine may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level.
DB09156
Ticlopidine may decrease the excretion rate of Iopromide which could result in a higher serum level.
DB09163
Ticlopidine may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level.
DB09165
Ticlopidine may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level.
DB09185
Ticlopidine may decrease the excretion rate of Viloxazine which could result in a higher serum level.
DB09194
Ticlopidine may decrease the excretion rate of Etoperidone which could result in a higher serum level.
DB09205
Ticlopidine may decrease the excretion rate of Moxisylyte which could result in a higher serum level.
DB09209
Ticlopidine may decrease the excretion rate of Pholcodine which could result in a higher serum level.
DB09210
Ticlopidine may decrease the excretion rate of Piracetam which could result in a higher serum level.
DB09219
Ticlopidine may decrease the excretion rate of Bisoxatin which could result in a higher serum level.
DB09220
Ticlopidine may decrease the excretion rate of Nicorandil which could result in a higher serum level.
DB09223
Ticlopidine may decrease the excretion rate of Blonanserin which could result in a higher serum level.
DB09257
Ticlopidine may decrease the excretion rate of Gimeracil which could result in a higher serum level.
DB09262
Ticlopidine may decrease the excretion rate of Imidafenacin which could result in a higher serum level.
DB09264
Ticlopidine may decrease the excretion rate of Idarucizumab which could result in a higher serum level.
DB09265
Ticlopidine may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
DB09268
Ticlopidine may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level.
DB09276
Ticlopidine may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
DB09277
Ticlopidine may decrease the excretion rate of Choline C 11 which could result in a higher serum level.
DB09281
Ticlopidine may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.
DB09292
Ticlopidine may decrease the excretion rate of Sacubitril which could result in a higher serum level.
DB09301
Ticlopidine may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level.
DB09317
Ticlopidine may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level.
DB09318
Ticlopidine may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level.
DB09320
Ticlopidine may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
DB09324
Ticlopidine may decrease the excretion rate of Sulbactam which could result in a higher serum level.
DB09325
Ticlopidine may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
DB09329
Ticlopidine may decrease the excretion rate of Antihemophilic Factor (Recombinant), PEGylated which could result in a higher serum level.
DB09344
Ticlopidine may decrease the excretion rate of Invert sugar which could result in a higher serum level.
DB09357
Ticlopidine may decrease the excretion rate of Dexpanthenol which could result in a higher serum level.
DB09394
Ticlopidine may decrease the excretion rate of Phosphoric acid which could result in a higher serum level.
DB09395
Ticlopidine may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
DB09407
Ticlopidine may decrease the excretion rate of Magnesium chloride which could result in a higher serum level.
DB09418
Ticlopidine may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level.
DB09472
Ticlopidine may decrease the excretion rate of Sodium sulfate which could result in a higher serum level.
DB09477
Ticlopidine may decrease the excretion rate of Enalaprilat which could result in a higher serum level.
DB09481
Ticlopidine may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
DB09488
Ticlopidine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
DB09496
Ticlopidine may decrease the excretion rate of Octinoxate which could result in a higher serum level.
DB09502
Ticlopidine may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
DB09546
Ticlopidine may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level.
DB11077
Ticlopidine may decrease the excretion rate of Polyethylene glycol 400 which could result in a higher serum level.
DB11090
Ticlopidine may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
DB11098
Ticlopidine may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
DB11102
Ticlopidine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
DB11114
Ticlopidine may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
DB11127
Ticlopidine may decrease the excretion rate of Selenious acid which could result in a higher serum level.
DB11135
Ticlopidine may decrease the excretion rate of Selenium which could result in a higher serum level.
DB11136
Ticlopidine may decrease the excretion rate of Chromium which could result in a higher serum level.
DB11145
Ticlopidine may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
DB11156
Ticlopidine may decrease the excretion rate of Pyrantel which could result in a higher serum level.
DB11164
Ticlopidine may decrease the excretion rate of Bicisate which could result in a higher serum level.
DB11251
Ticlopidine may decrease the excretion rate of Tocopherol which could result in a higher serum level.
DB11278
Ticlopidine may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level.
DB11328
Ticlopidine may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
DB11338
Ticlopidine may decrease the excretion rate of Clove oil which could result in a higher serum level.
DB11358
Ticlopidine may decrease the excretion rate of Evening primrose oil which could result in a higher serum level.
DB11364
Ticlopidine may decrease the excretion rate of Pidotimod which could result in a higher serum level.
DB11577
Ticlopidine may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level.
DB11587
Ticlopidine may decrease the excretion rate of Etafedrine which could result in a higher serum level.
DB11691
Ticlopidine may decrease the excretion rate of Naldemedine which could result in a higher serum level.
DB11699
Ticlopidine may decrease the excretion rate of Tropisetron which could result in a higher serum level.
DB11943
Ticlopidine may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
DB11989
Ticlopidine may decrease the excretion rate of Benznidazole which could result in a higher serum level.
DB12007
Ticlopidine may decrease the excretion rate of Isoflavone which could result in a higher serum level.
DB12107
Ticlopidine may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
DB12278
Ticlopidine may decrease the excretion rate of Propiverine which could result in a higher serum level.
DB12783
Ticlopidine may decrease the excretion rate of Benserazide which could result in a higher serum level.
DB13025
Ticlopidine may decrease the excretion rate of Tiapride which could result in a higher serum level.
DB13156
Ticlopidine may decrease the excretion rate of Inosine pranobex which could result in a higher serum level.
DB13178
Ticlopidine may decrease the excretion rate of Inositol which could result in a higher serum level.
DB13185
Ticlopidine may decrease the excretion rate of Oxabolone cipionate which could result in a higher serum level.
DB13191
Ticlopidine may decrease the excretion rate of Phosphocreatine which could result in a higher serum level.
DB13269
Ticlopidine may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
DB13595
Ticlopidine may decrease the excretion rate of Almasilate which could result in a higher serum level.
DB13873
Ticlopidine may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
DB13884
Ticlopidine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
DB13909
Ticlopidine may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
DB13967
Ticlopidine may decrease the excretion rate of Patent Blue which could result in a higher serum level.
DB14007
Ticlopidine may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
DB14498
Ticlopidine may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
DB14499
Ticlopidine may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
DB14526
Ticlopidine may decrease the excretion rate of Chromic citrate which could result in a higher serum level.
DB14527
Ticlopidine may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
DB14528
Ticlopidine may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
DB14529
Ticlopidine may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.
DB14530
Ticlopidine may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
DB14754
Ticlopidine may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
DB06815
Ticlopidine may decrease the excretion rate of Pyrithione which could result in a higher serum level.
DB11121
Ticlopidine may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
DB00231
Ticlopidine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11085
Ticlopidine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
DB15593
Ticlopidine may decrease the excretion rate of Golodirsen which could result in a higher serum level.
DB00820
Ticlopidine may decrease the excretion rate of Tadalafil which could result in a higher serum level.
DB00401
Ticlopidine may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
DB00813
Ticlopidine may decrease the excretion rate of Fentanyl which could result in a higher serum level.
DB00879
Ticlopidine may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
DB00897
Ticlopidine may decrease the excretion rate of Triazolam which could result in a higher serum level.
DB08996
Ticlopidine may decrease the excretion rate of Dimetacrine which could result in a higher serum level.
DB14506
Ticlopidine may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level.
DB00404
Ticlopidine may decrease the excretion rate of Alprazolam which could result in a higher serum level.
DB13987
Ticlopidine may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
DB04890
Ticlopidine may decrease the excretion rate of Bepotastine which could result in a higher serum level.
DB00982
Ticlopidine may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
DB00479
Amikacin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00684
Tobramycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00798
Gentamicin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00955
Netilmicin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00994
Neomycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01082
Streptomycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB01172
Kanamycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB03615
Ribostamycin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB04729
Gentamicin C1a may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB06696
Arbekacin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB12604
Sisomicin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB13540
Isepamicin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00552
Ticlopidine may decrease the excretion rate of Pentostatin which could result in a higher serum level.
DB13145
Ticlopidine may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
DB00314
Ticlopidine may decrease the excretion rate of Capreomycin which could result in a higher serum level.
DB00390
Ticlopidine may decrease the excretion rate of Digoxin which could result in a higher serum level.
DB00512
Ticlopidine may decrease the excretion rate of Vancomycin which could result in a higher serum level.
DB00515
Ticlopidine may decrease the excretion rate of Cisplatin which could result in a higher serum level.
DB00642
Ticlopidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
DB12615
Ticlopidine may decrease the excretion rate of Plazomicin which could result in a higher serum level.
DB14509
Ticlopidine may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
DB00803
Colistin may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
DB00524
Ticlopidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
DB00695
Ticlopidine may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
DB00808
Ticlopidine may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
DB00887
Ticlopidine may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
DB08907
Ticlopidine may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
DB09338
Ticlopidine may increase the excretion rate of Mersalyl which could result in a lower serum level and potentially a reduction in efficacy.
DB00232
Methyclothiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00310
Chlorthalidone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00311
Ethoxzolamide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00421
Spironolactone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00436
Bendroflumethiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00562
Benzthiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00594
Amiloride may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00606
Cyclothiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00774
Hydroflumethiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00880
Chlorothiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB01021
Trichlormethiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB01119
Diazoxide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB01144
Diclofenamide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB01324
Polythiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB01325
Quinethazone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB02925
Piretanide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB04831
Tienilic acid may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB05034
Ularitide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB08961
Azosemide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB09015
Canrenoic acid may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB09401
Isosorbide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB11827
Ertugliflozin may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB12221
Canrenone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB12670
Rolofylline may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB12704
Spiradoline may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB12766
Cicletanine may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13284
Meticrane may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13405
Mefruside may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13430
Mebutizide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13532
Cyclopenthiazide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13617
Clorexolone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13663
Clofenamide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13708
Fenquizone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13792
Clopamide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13801
Muzolimine may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13803
Xipamide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB13989
Epitizide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB14500
Potassium may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00214
Ticlopidine may increase the excretion rate of Torasemide which could result in a lower serum level and potentially a reduction in efficacy.
DB00703
Methazolamide may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB00700
Eplerenone may increase the excretion rate of Ticlopidine which could result in a lower serum level and potentially a reduction in efficacy.
DB01345
Ticlopidine may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
DB00601
The risk or severity of bleeding and hemorrhage can be increased when Linezolid is combined with Ticlopidine.
DB00614
The risk or severity of bleeding and hemorrhage can be increased when Furazolidone is combined with Ticlopidine.
DB00721
The risk or severity of bleeding and hemorrhage can be increased when Procaine is combined with Ticlopidine.
DB00780
The risk or severity of bleeding and hemorrhage can be increased when Phenelzine is combined with Ticlopidine.
DB00805
The risk or severity of bleeding and hemorrhage can be increased when Minaprine is combined with Ticlopidine.
DB01168
The risk or severity of bleeding and hemorrhage can be increased when Procarbazine is combined with Ticlopidine.
DB01171
The risk or severity of bleeding and hemorrhage can be increased when Moclobemide is combined with Ticlopidine.
DB01247
The risk or severity of bleeding and hemorrhage can be increased when Isocarboxazid is combined with Ticlopidine.
DB01367
The risk or severity of bleeding and hemorrhage can be increased when Rasagiline is combined with Ticlopidine.
DB01626
The risk or severity of bleeding and hemorrhage can be increased when Pargyline is combined with Ticlopidine.
DB04017
The risk or severity of bleeding and hemorrhage can be increased when Clorgiline is combined with Ticlopidine.
DB04818
The risk or severity of bleeding and hemorrhage can be increased when Iproniazid is combined with Ticlopidine.
DB04820
The risk or severity of bleeding and hemorrhage can be increased when Nialamide is combined with Ticlopidine.
DB06654
The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Ticlopidine.
DB08550
The risk or severity of bleeding and hemorrhage can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Ticlopidine.
DB09241
The risk or severity of bleeding and hemorrhage can be increased when Methylene blue is combined with Ticlopidine.
DB09243
The risk or severity of bleeding and hemorrhage can be increased when Hydracarbazine is combined with Ticlopidine.
DB09244
The risk or severity of bleeding and hemorrhage can be increased when Pirlindole is combined with Ticlopidine.
DB09245
The risk or severity of bleeding and hemorrhage can be increased when Toloxatone is combined with Ticlopidine.
DB09246
The risk or severity of bleeding and hemorrhage can be increased when Benmoxin is combined with Ticlopidine.
DB09248
The risk or severity of bleeding and hemorrhage can be increased when Mebanazine is combined with Ticlopidine.
DB09249
The risk or severity of bleeding and hemorrhage can be increased when Octamoxin is combined with Ticlopidine.
DB09250
The risk or severity of bleeding and hemorrhage can be increased when Pheniprazine is combined with Ticlopidine.
DB09251
The risk or severity of bleeding and hemorrhage can be increased when Phenoxypropazine is combined with Ticlopidine.
DB09252
The risk or severity of bleeding and hemorrhage can be increased when Pivhydrazine is combined with Ticlopidine.
DB09253
The risk or severity of bleeding and hemorrhage can be increased when Safrazine is combined with Ticlopidine.
DB09254
The risk or severity of bleeding and hemorrhage can be increased when Caroxazone is combined with Ticlopidine.
DB13875
The risk or severity of bleeding and hemorrhage can be increased when Harmaline is combined with Ticlopidine.
DB13876
The risk or severity of bleeding and hemorrhage can be increased when Brofaromine is combined with Ticlopidine.
DB00182
The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Ticlopidine.
DB09046
The metabolism of Ticlopidine can be increased when combined with Metreleptin.
DB11560
The metabolism of Lesinurad can be increased when combined with Ticlopidine.
DB00949
The metabolism of Ticlopidine can be increased when combined with Felbamate.
DB06201
The metabolism of Ticlopidine can be increased when combined with Rufinamide.
DB06413
The metabolism of Ticlopidine can be increased when combined with Armodafinil.
DB09119
The metabolism of Ticlopidine can be increased when combined with Eslicarbazepine acetate.
DB11767
The metabolism of Ticlopidine can be increased when combined with Sarilumab.
DB00615
The metabolism of Ticlopidine can be increased when combined with Rifabutin.
DB04911
The metabolism of Ticlopidine can be increased when combined with Oritavancin.
DB00273
The metabolism of Topiramate can be increased when combined with Ticlopidine.
DB00418
The metabolism of Secobarbital can be increased when combined with Ticlopidine.
DB00591
The metabolism of Fluocinolone acetonide can be increased when combined with Ticlopidine.
DB00603
The metabolism of Medroxyprogesterone acetate can be increased when combined with Ticlopidine.
DB01011
The metabolism of Metyrapone can be increased when combined with Ticlopidine.
DB01030
The metabolism of Topotecan can be increased when combined with Ticlopidine.
DB01032
The metabolism of Probenecid can be increased when combined with Ticlopidine.
DB08905
The metabolism of Formestane can be increased when combined with Ticlopidine.
DB08911
The metabolism of Trametinib can be increased when combined with Ticlopidine.
DB13952
The metabolism of Estradiol acetate can be increased when combined with Ticlopidine.
DB13954
The metabolism of Estradiol cypionate can be increased when combined with Ticlopidine.
DB13955
The metabolism of Estradiol dienanthate can be increased when combined with Ticlopidine.
DB13956
The metabolism of Estradiol valerate can be increased when combined with Ticlopidine.
DB00082
The metabolism of Ticlopidine can be increased when combined with Pegvisomant.
DB00136
The metabolism of Ticlopidine can be increased when combined with Calcitriol.
DB00180
The metabolism of Ticlopidine can be increased when combined with Flunisolide.
DB00197
The metabolism of Ticlopidine can be increased when combined with Troglitazone.
DB00241
The metabolism of Ticlopidine can be increased when combined with Butalbital.
DB00301
The metabolism of Ticlopidine can be increased when combined with Flucloxacillin.
DB00357
The metabolism of Ticlopidine can be increased when combined with Aminoglutethimide.
DB00394
The metabolism of Ticlopidine can be increased when combined with Beclomethasone dipropionate.
DB00400
The metabolism of Ticlopidine can be increased when combined with Griseofulvin.
DB00439
The metabolism of Ticlopidine can be increased when combined with Cerivastatin.
DB00443
The metabolism of Ticlopidine can be increased when combined with Betamethasone.
DB00485
The metabolism of Ticlopidine can be increased when combined with Dicloxacillin.
DB00620
The metabolism of Ticlopidine can be increased when combined with Triamcinolone.
DB00636
The metabolism of Ticlopidine can be increased when combined with Clofibrate.
DB00741
The metabolism of Ticlopidine can be increased when combined with Hydrocortisone.
DB00754
The metabolism of Ticlopidine can be increased when combined with Ethotoin.
DB00769
The metabolism of Ticlopidine can be increased when combined with Hydrocortamate.
DB00834
The metabolism of Ticlopidine can be increased when combined with Mifepristone.
DB00860
The metabolism of Ticlopidine can be increased when combined with Prednisolone.
DB00959
The metabolism of Ticlopidine can be increased when combined with Methylprednisolone.
DB01083
The metabolism of Ticlopidine can be increased when combined with Orlistat.
DB01154
The metabolism of Ticlopidine can be increased when combined with Thiamylal.
DB01201
The metabolism of Ticlopidine can be increased when combined with Rifapentine.
DB01285
The metabolism of Ticlopidine can be increased when combined with Corticotropin.
DB01351
The metabolism of Ticlopidine can be increased when combined with Amobarbital.
DB01352
The metabolism of Ticlopidine can be increased when combined with Aprobarbital.
DB01380
The metabolism of Ticlopidine can be increased when combined with Cortisone acetate.
DB01384
The metabolism of Ticlopidine can be increased when combined with Paramethasone.
DB01609
The metabolism of Ticlopidine can be increased when combined with Deferasirox.
DB04920
The metabolism of Ticlopidine can be increased when combined with Clevidipine.
DB06636
The metabolism of Ticlopidine can be increased when combined with Isavuconazonium.
DB08906
The metabolism of Ticlopidine can be increased when combined with Fluticasone furoate.
DB08970
The metabolism of Ticlopidine can be increased when combined with Fluprednidene.
DB09001
The metabolism of Ticlopidine can be increased when combined with Barbexaclone.
DB09383
The metabolism of Ticlopidine can be increased when combined with Meprednisone.
DB11487
The metabolism of Ticlopidine can be increased when combined with Dexamethasone isonicotinate.
DB11921
The metabolism of Ticlopidine can be increased when combined with Deflazacort.
DB13003
The metabolism of Ticlopidine can be increased when combined with Cortivazol.
DB13208
The metabolism of Ticlopidine can be increased when combined with Prednylidene.
DB13843
The metabolism of Ticlopidine can be increased when combined with Cloprednol.
DB13867
The metabolism of Ticlopidine can be increased when combined with Fluticasone.
DB14512
The metabolism of Ticlopidine can be increased when combined with Mometasone furoate.
DB14539
The metabolism of Ticlopidine can be increased when combined with Hydrocortisone acetate.
DB14545
The metabolism of Ticlopidine can be increased when combined with Hydrocortisone succinate.
DB14631
The metabolism of Ticlopidine can be increased when combined with Prednisolone phosphate.
DB14633
The metabolism of Ticlopidine can be increased when combined with Prednisolone hemisuccinate.
DB14644
The metabolism of Ticlopidine can be increased when combined with Methylprednisolone hemisuccinate.
DB14646
The metabolism of Ticlopidine can be increased when combined with Prednisone acetate.
DB14652
The metabolism of Ticlopidine can be increased when combined with Clocortolone acetate.
DB14659
The metabolism of Ticlopidine can be increased when combined with Melengestrol acetate.
DB14669
The metabolism of Ticlopidine can be increased when combined with Betamethasone phosphate.
DB14681
The metabolism of Ticlopidine can be increased when combined with Cortisone.
DB00602
The metabolism of Ticlopidine can be increased when combined with Ivermectin.
DB00776
The metabolism of Ticlopidine can be increased when combined with Oxcarbazepine.
DB14575
The metabolism of Ticlopidine can be increased when combined with Eslicarbazepine.
DB01222
The metabolism of Ticlopidine can be increased when combined with Budesonide.
DB01394
The metabolism of Ticlopidine can be increased when combined with Colchicine.
DB06717
The metabolism of Ticlopidine can be increased when combined with Fosaprepitant.
DB01013
The metabolism of Ticlopidine can be increased when combined with Clobetasol propionate.
DB01047
The metabolism of Ticlopidine can be increased when combined with Fluocinonide.
DB14540
The metabolism of Ticlopidine can be increased when combined with Hydrocortisone butyrate.
DB00764
The metabolism of Ticlopidine can be increased when combined with Mometasone.
DB15822
The metabolism of Ticlopidine can be increased when combined with Pralsetinib.
DB08971
The metabolism of Ticlopidine can be increased when combined with Fluocortolone.
DB11750
The metabolism of Ticlopidine can be increased when combined with Clobetasol.
DB15566
The metabolism of Ticlopidine can be increased when combined with Prednisolone acetate.
DB09095
The metabolism of Difluocortolone can be increased when combined with Ticlopidine.
DB01369
The metabolism of Ticlopidine can be decreased when combined with Quinupristin.
DB01764
The metabolism of Ticlopidine can be decreased when combined with Dalfopristin.
DB04894
The metabolism of Ticlopidine can be decreased when combined with Vapreotide.
DB05928
The metabolism of Ticlopidine can be decreased when combined with Dovitinib.
DB06663
The metabolism of Ticlopidine can be decreased when combined with Pasireotide.
DB06791
The metabolism of Ticlopidine can be decreased when combined with Lanreotide.
DB09099
The metabolism of Ticlopidine can be decreased when combined with Somatostatin.
DB00778
The metabolism of Roxithromycin can be decreased when combined with Ticlopidine.
DB04839
The metabolism of Cyproterone acetate can be decreased when combined with Ticlopidine.
DB08820
The metabolism of Ivacaftor can be decreased when combined with Ticlopidine.
DB13941
The metabolism of Piperaquine can be decreased when combined with Ticlopidine.
DB13879
The metabolism of Ticlopidine can be decreased when combined with Glecaprevir.
DB04794
The metabolism of Ticlopidine can be decreased when combined with Bifonazole.
DB00041
The metabolism of Ticlopidine can be decreased when combined with Aldesleukin.
DB00254
The metabolism of Doxycycline can be decreased when combined with Ticlopidine.
DB00435
The metabolism of Nitric Oxide can be decreased when combined with Ticlopidine.
DB00759
The metabolism of Tetracycline can be decreased when combined with Ticlopidine.
DB01015
The metabolism of Sulfamethoxazole can be decreased when combined with Ticlopidine.
DB01093
The metabolism of Dimethyl sulfoxide can be decreased when combined with Ticlopidine.
DB01275
The metabolism of Hydralazine can be decreased when combined with Ticlopidine.
DB01587
The metabolism of Ketazolam can be decreased when combined with Ticlopidine.
DB01685
The metabolism of Topiroxostat can be decreased when combined with Ticlopidine.
DB00255
The metabolism of Ticlopidine can be decreased when combined with Diethylstilbestrol.
DB00317
The metabolism of Ticlopidine can be decreased when combined with Gefitinib.
DB00353
The metabolism of Ticlopidine can be decreased when combined with Methylergometrine.
DB00358
The metabolism of Ticlopidine can be decreased when combined with Mefloquine.
DB00446
The metabolism of Ticlopidine can be decreased when combined with Chloramphenicol.
DB00481
The metabolism of Ticlopidine can be decreased when combined with Raloxifene.
DB00549
The metabolism of Ticlopidine can be decreased when combined with Zafirlukast.
DB00588
The metabolism of Ticlopidine can be decreased when combined with Fluticasone propionate.
DB00627
The metabolism of Ticlopidine can be decreased when combined with Niacin.
DB00647
The metabolism of Ticlopidine can be decreased when combined with Dextropropoxyphene.
DB00668
The metabolism of Ticlopidine can be decreased when combined with Epinephrine.
DB00678
The metabolism of Ticlopidine can be decreased when combined with Losartan.
DB00819
The metabolism of Ticlopidine can be decreased when combined with Acetazolamide.
DB00845
The metabolism of Ticlopidine can be decreased when combined with Clofazimine.
DB00916
The metabolism of Ticlopidine can be decreased when combined with Metronidazole.
DB00954
The metabolism of Ticlopidine can be decreased when combined with Dirithromycin.
DB01029
The metabolism of Ticlopidine can be decreased when combined with Irbesartan.
DB01059
The metabolism of Ticlopidine can be decreased when combined with Norfloxacin.
DB01062
The metabolism of Ticlopidine can be decreased when combined with Oxybutynin.
DB01071
The metabolism of Ticlopidine can be decreased when combined with Mequitazine.
DB01085
The metabolism of Ticlopidine can be decreased when combined with Pilocarpine.
DB01152
The metabolism of Ticlopidine can be decreased when combined with Candicidin.
DB01204
The metabolism of Ticlopidine can be decreased when combined with Mitoxantrone.
DB01388
The metabolism of Ticlopidine can be decreased when combined with Mibefradil.
DB01698
The metabolism of Ticlopidine can be decreased when combined with Rutin.
DB01873
The metabolism of Ticlopidine can be decreased when combined with Epothilone D.
DB03010
The metabolism of Ticlopidine can be decreased when combined with Patupilone.
DB04070
The metabolism of Ticlopidine can be decreased when combined with 6-Deoxyerythronolide B.
DB05482
The metabolism of Ticlopidine can be decreased when combined with 7-ethyl-10-hydroxycamptothecin.
DB05814
The metabolism of Ticlopidine can be decreased when combined with GPI-1485.
DB05903
The metabolism of Ticlopidine can be decreased when combined with KOS-1584.
DB06174
The metabolism of Ticlopidine can be decreased when combined with Noscapine.
DB06233
The metabolism of Ticlopidine can be decreased when combined with Ridaforolimus.
DB06268
The metabolism of Ticlopidine can be decreased when combined with Sitaxentan.
DB06318
The metabolism of Ticlopidine can be decreased when combined with AVE9633.
DB06342
The metabolism of Ticlopidine can be decreased when combined with Coltuximab ravtansine.
DB06370
The metabolism of Ticlopidine can be decreased when combined with Indisulam.
DB06412
The metabolism of Ticlopidine can be decreased when combined with Oxymetholone.
DB06419
The metabolism of Ticlopidine can be decreased when combined with Cethromycin.
DB06458
The metabolism of Ticlopidine can be decreased when combined with Remacemide.
DB06469
The metabolism of Ticlopidine can be decreased when combined with Lestaurtinib.
DB06587
The metabolism of Ticlopidine can be decreased when combined with Mitemcinal.
DB07348
The metabolism of Ticlopidine can be decreased when combined with Brefeldin A.
DB08811
The metabolism of Ticlopidine can be decreased when combined with Tofisopam.
DB09235
The metabolism of Ticlopidine can be decreased when combined with Efonidipine.
DB09308
The metabolism of Ticlopidine can be decreased when combined with Solithromycin.
DB09309
The metabolism of Ticlopidine can be decreased when combined with Kitasamycin.
DB11198
The metabolism of Ticlopidine can be decreased when combined with Peppermint oil.
DB11383
The metabolism of Ticlopidine can be decreased when combined with Carbomycin.
DB11400
The metabolism of Ticlopidine can be decreased when combined with Doramectin.
DB11405
The metabolism of Ticlopidine can be decreased when combined with Eprinomectin.
DB11442
The metabolism of Ticlopidine can be decreased when combined with Oleandomycin.
DB11459
The metabolism of Ticlopidine can be decreased when combined with Selamectin.
DB11470
The metabolism of Ticlopidine can be decreased when combined with Tildipirosin.
DB11471
The metabolism of Ticlopidine can be decreased when combined with Tilmicosin.
DB11475
The metabolism of Ticlopidine can be decreased when combined with Tylosin.
DB11554
The metabolism of Ticlopidine can be decreased when combined with Tylvalosin.
DB11574
The metabolism of Ticlopidine can be decreased when combined with Elbasvir.
DB11752
The metabolism of Ticlopidine can be decreased when combined with Bryostatin 1.
DB11805
The metabolism of Ticlopidine can be decreased when combined with Saracatinib.
DB12010
The metabolism of Ticlopidine can be decreased when combined with Fostamatinib.
DB12070
The metabolism of Ticlopidine can be decreased when combined with Letermovir.
DB12089
The metabolism of Ticlopidine can be decreased when combined with Lorvotuzumab mertansine.
DB12266
The metabolism of Ticlopidine can be decreased when combined with Epofolate.
DB12391
The metabolism of Ticlopidine can be decreased when combined with Sagopilone.
DB12489
The metabolism of Ticlopidine can be decreased when combined with Mirvetuximab Soravtansine.
DB12532
The metabolism of Ticlopidine can be decreased when combined with Oxetacaine.
DB13287
The metabolism of Ticlopidine can be decreased when combined with Miocamycin.
DB13338
The metabolism of Ticlopidine can be decreased when combined with Flurithromycin.
DB13409
The metabolism of Ticlopidine can be decreased when combined with Rokitamycin.
DB13456
The metabolism of Ticlopidine can be decreased when combined with Midecamycin.
DB13950
The metabolism of Ticlopidine can be decreased when combined with WIN 55212-2.
DB13975
The metabolism of Ticlopidine can be decreased when combined with Black cohosh.
DB14009
The metabolism of Medical Cannabis can be decreased when combined with Ticlopidine.
DB01095
The metabolism of Ticlopidine can be decreased when combined with Fluvastatin.
DB00701
The metabolism of Ticlopidine can be decreased when combined with Amprenavir.
DB14635
The metabolism of Ticlopidine can be decreased when combined with Curcumin sulfate.
DB00683
The metabolism of Midazolam can be decreased when combined with Ticlopidine.
DB01023
The metabolism of Ticlopidine can be decreased when combined with Felodipine.
DB01200
The metabolism of Ticlopidine can be decreased when combined with Bromocriptine.
DB00104
The metabolism of Ticlopidine can be decreased when combined with Octreotide.
DB00694
The metabolism of Daunorubicin can be decreased when combined with Ticlopidine.
DB13633
The metabolism of Ticlopidine can be decreased when combined with Mepartricin.
DB00619
The metabolism of Ticlopidine can be decreased when combined with Imatinib.
DB09073
The metabolism of Palbociclib can be decreased when combined with Ticlopidine.
DB00563
The metabolism of Ticlopidine can be decreased when combined with Methotrexate.
DB08877
The metabolism of Ruxolitinib can be decreased when combined with Ticlopidine.
DB11817
The metabolism of Baricitinib can be decreased when combined with Ticlopidine.
DB08865
The metabolism of Ticlopidine can be decreased when combined with Crizotinib.
DB11581
The metabolism of Ticlopidine can be decreased when combined with Venetoclax.
DB12015
The metabolism of Ticlopidine can be decreased when combined with Alpelisib.
DB00570
The metabolism of Ticlopidine can be decreased when combined with Vinblastine.
DB08881
The metabolism of Ticlopidine can be decreased when combined with Vemurafenib.
DB09330
The metabolism of Ticlopidine can be decreased when combined with Osimertinib.
DB14568
The metabolism of Ticlopidine can be decreased when combined with Ivosidenib.
DB11703
The metabolism of Ticlopidine can be decreased when combined with Acalabrutinib.
DB00248
The metabolism of Ticlopidine can be decreased when combined with Cabergoline.
DB00997
The metabolism of Ticlopidine can be decreased when combined with Doxorubicin.
DB01248
The metabolism of Ticlopidine can be decreased when combined with Docetaxel.
DB01268
The metabolism of Ticlopidine can be decreased when combined with Sunitinib.
DB05773
The metabolism of Ticlopidine can be decreased when combined with Trastuzumab emtansine.
DB06616
The metabolism of Ticlopidine can be decreased when combined with Bosutinib.
DB08870
The metabolism of Ticlopidine can be decreased when combined with Brentuximab vedotin.
DB08896
The metabolism of Ticlopidine can be decreased when combined with Regorafenib.
DB00204
The metabolism of Dofetilide can be decreased when combined with Ticlopidine.
DB00864
The metabolism of Tacrolimus can be decreased when combined with Ticlopidine.
DB00877
The metabolism of Sirolimus can be decreased when combined with Ticlopidine.
DB01008
The metabolism of Busulfan can be decreased when combined with Ticlopidine.
DB01396
The metabolism of Digitoxin can be decreased when combined with Ticlopidine.
DB01590
The metabolism of Everolimus can be decreased when combined with Ticlopidine.
DB06287
The metabolism of Temsirolimus can be decreased when combined with Ticlopidine.
DB09289
The metabolism of Tianeptine can be decreased when combined with Ticlopidine.
DB05239
The metabolism of Cobimetinib can be decreased when combined with Ticlopidine.
DB09063
The metabolism of Ceritinib can be decreased when combined with Ticlopidine.
DB09074
The metabolism of Olaparib can be decreased when combined with Ticlopidine.
DB01128
The metabolism of Ticlopidine can be decreased when combined with Bicalutamide.
DB00188
The metabolism of Bortezomib can be decreased when combined with Ticlopidine.
DB00361
The metabolism of Ticlopidine can be decreased when combined with Vinorelbine.
DB00309
The metabolism of Vindesine can be decreased when combined with Ticlopidine.
DB04572
The metabolism of Thiotepa can be decreased when combined with Ticlopidine.
DB06212
The metabolism of Ticlopidine can be decreased when combined with Tolvaptan.
DB08827
The metabolism of Ticlopidine can be decreased when combined with Lomitapide.
DB00320
The metabolism of Ticlopidine can be decreased when combined with Dihydroergotamine.
DB00541
The metabolism of Vincristine can be decreased when combined with Ticlopidine.
DB05294
The metabolism of Vandetanib can be decreased when combined with Ticlopidine.
DB11363
The metabolism of Alectinib can be decreased when combined with Ticlopidine.
DB11641
The metabolism of Vinflunine can be decreased when combined with Ticlopidine.
DB04845
The metabolism of Ixabepilone can be decreased when combined with Ticlopidine.
DB09054
The metabolism of Idelalisib can be decreased when combined with Ticlopidine.
DB09143
The metabolism of Sonidegib can be decreased when combined with Ticlopidine.
DB11828
The metabolism of Neratinib can be decreased when combined with Ticlopidine.
DB11986
The metabolism of Entrectinib can be decreased when combined with Ticlopidine.
DB12483
The metabolism of Copanlisib can be decreased when combined with Ticlopidine.
DB12978
The metabolism of Pexidartinib can be decreased when combined with Ticlopidine.
DB09570
The metabolism of Ixazomib can be decreased when combined with Ticlopidine.
DB12001
The metabolism of Abemaciclib can be decreased when combined with Ticlopidine.
DB01227
The metabolism of Levacetylmethadol can be decreased when combined with Ticlopidine.
DB00186
The metabolism of Ticlopidine can be decreased when combined with Lorazepam.
DB01039
The metabolism of Fenofibrate can be decreased when combined with Ticlopidine.
DB01431
The metabolism of Allylestrenol can be decreased when combined with Ticlopidine.
DB01656
The metabolism of Roflumilast can be decreased when combined with Ticlopidine.
DB06480
The metabolism of Prucalopride can be decreased when combined with Ticlopidine.
DB00191
The metabolism of Ticlopidine can be decreased when combined with Phentermine.
DB00207
The metabolism of Ticlopidine can be decreased when combined with Azithromycin.
DB00426
The metabolism of Famciclovir can be decreased when combined with Ticlopidine.
DB00717
The metabolism of Norethisterone can be decreased when combined with Ticlopidine.
DB01098
The metabolism of Rosuvastatin can be decreased when combined with Ticlopidine.
DB01411
The metabolism of Pranlukast can be decreased when combined with Ticlopidine.
DB09034
The metabolism of Suvorexant can be decreased when combined with Ticlopidine.
DB09079
The metabolism of Nintedanib can be decreased when combined with Ticlopidine.
DB11094
The metabolism of Vitamin D can be decreased when combined with Ticlopidine.
DB11273
The metabolism of Dihydroergocornine can be decreased when combined with Ticlopidine.
DB11952
The metabolism of Duvelisib can be decreased when combined with Ticlopidine.
DB12141
The metabolism of Gilteritinib can be decreased when combined with Ticlopidine.
DB12515
The metabolism of 9-aminocamptothecin can be decreased when combined with Ticlopidine.
DB12952
The metabolism of Methylprednisone can be decreased when combined with Ticlopidine.
DB13345
The metabolism of Dihydroergocristine can be decreased when combined with Ticlopidine.
DB13385
The metabolism of Dihydroergocryptine can be decreased when combined with Ticlopidine.
DB01395
The metabolism of Drospirenone can be decreased when combined with Ticlopidine.
DB15444
The metabolism of Elexacaftor can be decreased when combined with Ticlopidine.
DB12825
The metabolism of Lefamulin can be decreased when combined with Ticlopidine.
DB12887
The metabolism of Tazemetostat can be decreased when combined with Ticlopidine.
DB00247
The metabolism of Methysergide can be decreased when combined with Ticlopidine.
DB11742
The metabolism of Ebastine can be decreased when combined with Ticlopidine.
DB00613
The metabolism of Amodiaquine can be decreased when combined with Ticlopidine.
DB00799
The metabolism of Tazarotene can be decreased when combined with Ticlopidine.
DB06510
The metabolism of Muraglitazar can be decreased when combined with Ticlopidine.
DB08860
The metabolism of Pitavastatin can be decreased when combined with Ticlopidine.
DB09080
The metabolism of Olodaterol can be decreased when combined with Ticlopidine.
DB09296
The metabolism of Ombitasvir can be decreased when combined with Ticlopidine.
DB01217
The metabolism of Anastrozole can be decreased when combined with Ticlopidine.
DB00912
The metabolism of Repaglinide can be decreased when combined with Ticlopidine.
DB06670
The metabolism of Odanacatib can be decreased when combined with Ticlopidine.
DB08502
The metabolism of Capravirine can be decreased when combined with Ticlopidine.
DB08931
The metabolism of Riociguat can be decreased when combined with Ticlopidine.
DB09198
The metabolism of Lobeglitazone can be decreased when combined with Ticlopidine.
DB09199
The metabolism of Netoglitazone can be decreased when combined with Ticlopidine.
DB09200
The metabolism of Rivoglitazone can be decreased when combined with Ticlopidine.
DB09201
The metabolism of Ciglitazone can be decreased when combined with Ticlopidine.
DB11362
The metabolism of Selexipag can be decreased when combined with Ticlopidine.
DB11978
The metabolism of Glasdegib can be decreased when combined with Ticlopidine.
DB12781
The metabolism of Balaglitazone can be decreased when combined with Ticlopidine.
DB01076
The metabolism of Atorvastatin can be decreased when combined with Ticlopidine.
DB01132
The metabolism of Pioglitazone can be decreased when combined with Ticlopidine.
DB12612
The metabolism of Ozanimod can be decreased when combined with Ticlopidine.
DB01118
The metabolism of Amiodarone can be decreased when combined with Ticlopidine.
DB01229
The metabolism of Paclitaxel can be decreased when combined with Ticlopidine.
DB13874
The metabolism of Enasidenib can be decreased when combined with Ticlopidine.
DB00398
The metabolism of Sorafenib can be decreased when combined with Ticlopidine.
DB08912
The metabolism of Ticlopidine can be decreased when combined with Dabrafenib.
DB12267
The metabolism of Ticlopidine can be decreased when combined with Brigatinib.
DB08901
The metabolism of Ponatinib can be decreased when combined with Ticlopidine.
DB00530
The metabolism of Erlotinib can be decreased when combined with Ticlopidine.
DB00544
The metabolism of Fluorouracil can be decreased when combined with Ticlopidine.
DB06589
The metabolism of Pazopanib can be decreased when combined with Ticlopidine.
DB09256
The metabolism of Tegafur can be decreased when combined with Ticlopidine.
DB06772
The metabolism of Cabazitaxel can be decreased when combined with Ticlopidine.
DB00444
The metabolism of Ticlopidine can be decreased when combined with Teniposide.
DB00228
The metabolism of Enflurane can be decreased when combined with Ticlopidine.
DB06728
The metabolism of Aniline can be decreased when combined with Ticlopidine.
DB08868
The metabolism of Fingolimod can be decreased when combined with Ticlopidine.
DB00593
The metabolism of Ethosuximide can be decreased when combined with Ticlopidine.
DB00675
The metabolism of Tamoxifen can be decreased when combined with Ticlopidine.
DB01174
The metabolism of Phenobarbital can be decreased when combined with Ticlopidine.
DB05109
The metabolism of Trabectedin can be decreased when combined with Ticlopidine.
DB00184
The metabolism of Nicotine can be decreased when combined with Ticlopidine.
DB00238
The metabolism of Nevirapine can be decreased when combined with Ticlopidine.
DB00379
The metabolism of Mexiletine can be decreased when combined with Ticlopidine.
DB00568
The metabolism of Cinnarizine can be decreased when combined with Ticlopidine.
DB00625
The metabolism of Efavirenz can be decreased when combined with Ticlopidine.
DB00661
The metabolism of Verapamil can be decreased when combined with Ticlopidine.
DB00753
The metabolism of Isoflurane can be decreased when combined with Ticlopidine.
DB00755
The metabolism of Tretinoin can be decreased when combined with Ticlopidine.
DB00762
The metabolism of Irinotecan can be decreased when combined with Ticlopidine.
DB00818
The metabolism of Propofol can be decreased when combined with Ticlopidine.
DB00835
The metabolism of Brompheniramine can be decreased when combined with Ticlopidine.
DB00836
The metabolism of Loperamide can be decreased when combined with Ticlopidine.
DB00865
The metabolism of Benzphetamine can be decreased when combined with Ticlopidine.
DB01028
The metabolism of Methoxyflurane can be decreased when combined with Ticlopidine.
DB01037
The metabolism of Selegiline can be decreased when combined with Ticlopidine.
DB01069
The metabolism of Promethazine can be decreased when combined with Ticlopidine.
DB01159
The metabolism of Halothane can be decreased when combined with Ticlopidine.
DB01184
The metabolism of Domperidone can be decreased when combined with Ticlopidine.
DB01221
The metabolism of Ketamine can be decreased when combined with Ticlopidine.
DB01236
The metabolism of Sevoflurane can be decreased when combined with Ticlopidine.
DB01466
The metabolism of Ethylmorphine can be decreased when combined with Ticlopidine.
DB01544
The metabolism of Flunitrazepam can be decreased when combined with Ticlopidine.
DB01559
The metabolism of Clotiazepam can be decreased when combined with Ticlopidine.
DB04938
The metabolism of Ospemifene can be decreased when combined with Ticlopidine.
DB04975
The metabolism of Banoxantrone can be decreased when combined with Ticlopidine.
DB05541
The metabolism of Brivaracetam can be decreased when combined with Ticlopidine.
DB06148
The metabolism of Mianserin can be decreased when combined with Ticlopidine.
DB06176
The metabolism of Romidepsin can be decreased when combined with Ticlopidine.
DB06470
The metabolism of Clomethiazole can be decreased when combined with Ticlopidine.
DB06710
The metabolism of Methyltestosterone can be decreased when combined with Ticlopidine.
DB06738
The metabolism of Ketobemidone can be decreased when combined with Ticlopidine.
DB08883
The metabolism of Perampanel can be decreased when combined with Ticlopidine.
DB11613
The metabolism of Velpatasvir can be decreased when combined with Ticlopidine.
DB13132
The metabolism of Artemisinin can be decreased when combined with Ticlopidine.
DB13943
The metabolism of Testosterone cypionate can be decreased when combined with Ticlopidine.
DB13944
The metabolism of Testosterone enanthate can be decreased when combined with Ticlopidine.
DB13946
The metabolism of Testosterone undecanoate can be decreased when combined with Ticlopidine.
DB00957
The metabolism of Ticlopidine can be decreased when combined with Norgestimate.
DB00604
The metabolism of Cisapride can be decreased when combined with Ticlopidine.
DB00956
The metabolism of Hydrocodone can be decreased when combined with Ticlopidine.
DB11757
The metabolism of Istradefylline can be decreased when combined with Ticlopidine.
DB11837
The metabolism of Ticlopidine can be decreased when combined with Osilodrostat.
DB00532
The metabolism of Mephenytoin can be decreased when combined with Ticlopidine.
DB00454
The metabolism of Meperidine can be decreased when combined with Ticlopidine.
DB13384
The metabolism of Melitracen can be decreased when combined with Ticlopidine.
DB13411
The metabolism of Lofepramine can be decreased when combined with Ticlopidine.
DB00714
The metabolism of Apomorphine can be decreased when combined with Ticlopidine.
DB00751
The metabolism of Epinastine can be decreased when combined with Ticlopidine.
DB00655
The metabolism of Estrone can be decreased when combined with Ticlopidine.
DB04930
The metabolism of Permethrin can be decreased when combined with Ticlopidine.
DB00531
The metabolism of Cyclophosphamide can be decreased when combined with Ticlopidine.
DB01181
The metabolism of Ifosfamide can be decreased when combined with Ticlopidine.
DB15035
The metabolism of Zanubrutinib can be decreased when combined with Ticlopidine.
DB00514
The metabolism of Dextromethorphan can be decreased when combined with Ticlopidine.
DB00850
The metabolism of Perphenazine can be decreased when combined with Ticlopidine.
DB00185
The metabolism of Ticlopidine can be decreased when combined with Cevimeline.
DB00245
The metabolism of Benzatropine can be decreased when combined with Ticlopidine.
DB00377
The metabolism of Palonosetron can be decreased when combined with Ticlopidine.
DB00674
The metabolism of Galantamine can be decreased when combined with Ticlopidine.
DB00706
The metabolism of Tamsulosin can be decreased when combined with Ticlopidine.
DB00731
The metabolism of Nateglinide can be decreased when combined with Ticlopidine.
DB00918
The metabolism of Almotriptan can be decreased when combined with Ticlopidine.
DB00960
The metabolism of Pindolol can be decreased when combined with Ticlopidine.
DB01036
The metabolism of Tolterodine can be decreased when combined with Ticlopidine.
DB01203
The metabolism of Nadolol can be decreased when combined with Ticlopidine.
DB01267
The metabolism of Paliperidone can be decreased when combined with Ticlopidine.
DB01274
The metabolism of Arformoterol can be decreased when combined with Ticlopidine.
DB01359
The metabolism of Penbutolol can be decreased when combined with Ticlopidine.
DB01409
The metabolism of Tiotropium can be decreased when combined with Ticlopidine.
DB01577
The metabolism of Metamfetamine can be decreased when combined with Ticlopidine.
DB06203
The metabolism of Alogliptin can be decreased when combined with Ticlopidine.
DB06702
The metabolism of Fesoterodine can be decreased when combined with Ticlopidine.
DB09195
The metabolism of Lorpiprazole can be decreased when combined with Ticlopidine.
DB09204
The metabolism of Arotinolol can be decreased when combined with Ticlopidine.
DB11130
The metabolism of Opium can be decreased when combined with Ticlopidine.
DB11915
The metabolism of Valbenazine can be decreased when combined with Ticlopidine.
DB12161
The metabolism of Deutetrabenazine can be decreased when combined with Ticlopidine.
DB13139
The metabolism of Levosalbutamol can be decreased when combined with Ticlopidine.
DB13293
The metabolism of Ipecac can be decreased when combined with Ticlopidine.
DB09061
The metabolism of Cannabidiol can be decreased when combined with Ticlopidine.
DB14011
The metabolism of Nabiximols can be decreased when combined with Ticlopidine.
DB00187
The metabolism of Esmolol can be decreased when combined with Ticlopidine.
DB00297
The metabolism of Bupivacaine can be decreased when combined with Ticlopidine.
DB00335
The metabolism of Atenolol can be decreased when combined with Ticlopidine.
DB00409
The metabolism of Remoxipride can be decreased when combined with Ticlopidine.
DB00433
The metabolism of Prochlorperazine can be decreased when combined with Ticlopidine.
DB00497
The metabolism of Oxycodone can be decreased when combined with Ticlopidine.
DB00589
The metabolism of Lisuride can be decreased when combined with Ticlopidine.
DB00592
The metabolism of Piperazine can be decreased when combined with Ticlopidine.
DB00699
The metabolism of Nicergoline can be decreased when combined with Ticlopidine.
DB00737
The metabolism of Meclizine can be decreased when combined with Ticlopidine.
DB00757
The metabolism of Dolasetron can be decreased when combined with Ticlopidine.
DB00843
The metabolism of Donepezil can be decreased when combined with Ticlopidine.
DB00866
The metabolism of Alprenolol can be decreased when combined with Ticlopidine.
DB00904
The metabolism of Ondansetron can be decreased when combined with Ticlopidine.
DB00914
The metabolism of Phenformin can be decreased when combined with Ticlopidine.
DB00921
The metabolism of Buprenorphine can be decreased when combined with Ticlopidine.
DB00933
The metabolism of Mesoridazine can be decreased when combined with Ticlopidine.
DB00972
The metabolism of Azelastine can be decreased when combined with Ticlopidine.
DB01075
The metabolism of Diphenhydramine can be decreased when combined with Ticlopidine.
DB01114
The metabolism of Chlorpheniramine can be decreased when combined with Ticlopidine.
DB01177
The metabolism of Idarubicin can be decreased when combined with Ticlopidine.
DB01192
The metabolism of Oxymorphone can be decreased when combined with Ticlopidine.
DB01193
The metabolism of Acebutolol can be decreased when combined with Ticlopidine.
DB01228
The metabolism of Encainide can be decreased when combined with Ticlopidine.
DB01233
The metabolism of Metoclopramide can be decreased when combined with Ticlopidine.
DB01244
The metabolism of Bepridil can be decreased when combined with Ticlopidine.
DB01255
The metabolism of Lisdexamfetamine can be decreased when combined with Ticlopidine.
DB01295
The metabolism of Bevantolol can be decreased when combined with Ticlopidine.
DB01297
The metabolism of Practolol can be decreased when combined with Ticlopidine.
DB01392
The metabolism of Yohimbine can be decreased when combined with Ticlopidine.
DB01429
The metabolism of Aprindine can be decreased when combined with Ticlopidine.
DB01454
The metabolism of Midomafetamine can be decreased when combined with Ticlopidine.
DB01472
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Ticlopidine.
DB01551
The metabolism of Dihydrocodeine can be decreased when combined with Ticlopidine.
DB01576
The metabolism of Dextroamphetamine can be decreased when combined with Ticlopidine.
DB01580
The metabolism of Oxprenolol can be decreased when combined with Ticlopidine.
DB01591
The metabolism of Solifenacin can be decreased when combined with Ticlopidine.
DB01621
The metabolism of Pipotiazine can be decreased when combined with Ticlopidine.
DB01624
The metabolism of Zuclopenthixol can be decreased when combined with Ticlopidine.
DB04829
The metabolism of Lysergic acid diethylamide can be decreased when combined with Ticlopidine.
DB04840
The metabolism of Debrisoquine can be decreased when combined with Ticlopidine.
DB04844
The metabolism of Tetrabenazine can be decreased when combined with Ticlopidine.
DB04846
The metabolism of Celiprolol can be decreased when combined with Ticlopidine.
DB04946
The metabolism of Iloperidone can be decreased when combined with Ticlopidine.
DB05271
The metabolism of Rotigotine can be decreased when combined with Ticlopidine.
DB06016
The metabolism of Cariprazine can be decreased when combined with Ticlopidine.
DB06144
The metabolism of Sertindole can be decreased when combined with Ticlopidine.
DB06204
The metabolism of Tapentadol can be decreased when combined with Ticlopidine.
DB06217
The metabolism of Vernakalant can be decreased when combined with Ticlopidine.
DB06506
The metabolism of Repinotan can be decreased when combined with Ticlopidine.
DB06608
The metabolism of Tafenoquine can be decreased when combined with Ticlopidine.
DB06678
The metabolism of Esmirtazapine can be decreased when combined with Ticlopidine.
DB06726
The metabolism of Bufuralol can be decreased when combined with Ticlopidine.
DB06727
The metabolism of Sparteine can be decreased when combined with Ticlopidine.
DB06735
The metabolism of Enclomiphene can be decreased when combined with Ticlopidine.
DB08807
The metabolism of Bopindolol can be decreased when combined with Ticlopidine.
DB08808
The metabolism of Bupranolol can be decreased when combined with Ticlopidine.
DB08922
The metabolism of Perospirone can be decreased when combined with Ticlopidine.
DB08952
The metabolism of Indenolol can be decreased when combined with Ticlopidine.
DB09076
The metabolism of Umeclidinium can be decreased when combined with Ticlopidine.
DB09128
The metabolism of Brexpiprazole can be decreased when combined with Ticlopidine.
DB09183
The metabolism of Dasabuvir can be decreased when combined with Ticlopidine.
DB09351
The metabolism of Levobetaxolol can be decreased when combined with Ticlopidine.
DB09555
The metabolism of Dexchlorpheniramine maleate can be decreased when combined with Ticlopidine.
DB11614
The metabolism of Rupatadine can be decreased when combined with Ticlopidine.
DB11770
The metabolism of Talinolol can be decreased when combined with Ticlopidine.
DB11785
The metabolism of Anisodamine can be decreased when combined with Ticlopidine.
DB11855
The metabolism of Revefenacin can be decreased when combined with Ticlopidine.
DB11979
The metabolism of Elagolix can be decreased when combined with Ticlopidine.
DB12212
The metabolism of Landiolol can be decreased when combined with Ticlopidine.
DB12752
The metabolism of Bucindolol can be decreased when combined with Ticlopidine.
DB13443
The metabolism of Esatenolol can be decreased when combined with Ticlopidine.
DB13508
The metabolism of Cloranolol can be decreased when combined with Ticlopidine.
DB13530
The metabolism of Mepindolol can be decreased when combined with Ticlopidine.
DB13679
The metabolism of Dexchlorpheniramine can be decreased when combined with Ticlopidine.
DB13757
The metabolism of Epanolol can be decreased when combined with Ticlopidine.
DB13775
The metabolism of Tertatolol can be decreased when combined with Ticlopidine.
DB00283
The metabolism of Ticlopidine can be decreased when combined with Clemastine.
DB00412
The metabolism of Ticlopidine can be decreased when combined with Rosiglitazone.
DB00557
The metabolism of Ticlopidine can be decreased when combined with Hydroxyzine.
DB00574
The metabolism of Ticlopidine can be decreased when combined with Fenfluramine.
DB00633
The metabolism of Ticlopidine can be decreased when combined with Dexmedetomidine.
DB00792
The metabolism of Ticlopidine can be decreased when combined with Tripelennamine.
DB00810
The metabolism of Ticlopidine can be decreased when combined with Biperiden.
DB00907
The metabolism of Ticlopidine can be decreased when combined with Cocaine.
DB01005
The metabolism of Ticlopidine can be decreased when combined with Hydroxyurea.
DB01611
The metabolism of Ticlopidine can be decreased when combined with Hydroxychloroquine.
DB09078
The metabolism of Ticlopidine can be decreased when combined with Lenvatinib.
DB09224
The metabolism of Ticlopidine can be decreased when combined with Melperone.
DB11638
The metabolism of Ticlopidine can be decreased when combined with Artenimol.
DB11994
The metabolism of Ticlopidine can be decreased when combined with Diacerein.
DB12523
The metabolism of Ticlopidine can be decreased when combined with Mizolastine.
DB09173
The metabolism of Butyrfentanyl can be decreased when combined with Ticlopidine.
DB00734
The metabolism of Risperidone can be decreased when combined with Ticlopidine.
DB01410
The metabolism of Ciclesonide can be decreased when combined with Ticlopidine.
DB00220
The metabolism of Nelfinavir can be decreased when combined with Ticlopidine.
DB06691
The metabolism of Ticlopidine can be decreased when combined with Mepyramine.
DB00528
The metabolism of Lercanidipine can be decreased when combined with Ticlopidine.
DB01096
The metabolism of Ticlopidine can be decreased when combined with Oxamniquine.
DB04889
The metabolism of Bicifadine can be decreased when combined with Ticlopidine.
DB14010
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Ticlopidine.
DB01562
The metabolism of Ticlopidine can be decreased when combined with 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine.
DB01224
The metabolism of Quetiapine can be decreased when combined with Ticlopidine.
DB00203
The metabolism of Sildenafil can be decreased when combined with Ticlopidine.
DB00641
The metabolism of Simvastatin can be decreased when combined with Ticlopidine.
DB00490
The metabolism of Buspirone can be decreased when combined with Ticlopidine.
DB00216
The metabolism of Eletriptan can be decreased when combined with Ticlopidine.
DB00318
The metabolism of Codeine can be decreased when combined with Ticlopidine.
DB08864
The metabolism of Ticlopidine can be decreased when combined with Rilpivirine.
DB00344
The metabolism of Protriptyline can be decreased when combined with Ticlopidine.
DB09039
The metabolism of Eliglustat can be decreased when combined with Ticlopidine.
DB12930
The metabolism of Opipramol can be decreased when combined with Ticlopidine.
DB09049
The metabolism of Ticlopidine can be decreased when combined with Naloxegol.
DB14881
The metabolism of Oliceridine can be decreased when combined with Ticlopidine.
DB11718
The metabolism of Encorafenib can be decreased when combined with Ticlopidine.
DB11963
The metabolism of Ticlopidine can be decreased when combined with Dacomitinib.
DB01100
The metabolism of Pimozide can be decreased when combined with Ticlopidine.
DB01242
The metabolism of Clomipramine can be decreased when combined with Ticlopidine.
DB00575
The metabolism of Clonidine can be decreased when combined with Ticlopidine.
DB00726
The metabolism of Trimipramine can be decreased when combined with Ticlopidine.
DB00637
The metabolism of Ticlopidine can be decreased when combined with Astemizole.
DB00543
The metabolism of Amoxapine can be decreased when combined with Ticlopidine.
DB00540
The metabolism of Nortriptyline can be decreased when combined with Ticlopidine.
DB00209
The metabolism of Ticlopidine can be decreased when combined with Trospium.
DB00494
The metabolism of Ticlopidine can be decreased when combined with Entacapone.
DB00623
The metabolism of Ticlopidine can be decreased when combined with Fluphenazine.
DB06512
The metabolism of Ticlopidine can be decreased when combined with Deramciclane.
DB00234
The metabolism of Ticlopidine can be decreased when combined with Reboxetine.
DB00489
The metabolism of Sotalol can be decreased when combined with Ticlopidine.
DB01035
The metabolism of Procainamide can be decreased when combined with Ticlopidine.
DB01195
The metabolism of Flecainide can be decreased when combined with Ticlopidine.
DB00281
The metabolism of Lidocaine can be decreased when combined with Ticlopidine.
DB00296
The metabolism of Ropivacaine can be decreased when combined with Ticlopidine.
DB00195
The metabolism of Betaxolol can be decreased when combined with Ticlopidine.
DB00262
The metabolism of Carmustine can be decreased when combined with Ticlopidine.
DB00280
The metabolism of Disopyramide can be decreased when combined with Ticlopidine.
DB00286
The metabolism of Conjugated estrogens can be decreased when combined with Ticlopidine.
DB00334
The metabolism of Olanzapine can be decreased when combined with Ticlopidine.
DB00356
The metabolism of Chlorzoxazone can be decreased when combined with Ticlopidine.
DB00365
The metabolism of Grepafloxacin can be decreased when combined with Ticlopidine.
DB00370
The metabolism of Mirtazapine can be decreased when combined with Ticlopidine.
DB00382
The metabolism of Tacrine can be decreased when combined with Ticlopidine.
DB00384
The metabolism of Triamterene can be decreased when combined with Ticlopidine.
DB00420
The metabolism of Promazine can be decreased when combined with Ticlopidine.
DB00442
The metabolism of Entecavir can be decreased when combined with Ticlopidine.
DB00499
The metabolism of Flutamide can be decreased when combined with Ticlopidine.
DB00629
The metabolism of Guanabenz can be decreased when combined with Ticlopidine.
DB00730
The metabolism of Thiabendazole can be decreased when combined with Ticlopidine.
DB00740
The metabolism of Riluzole can be decreased when combined with Ticlopidine.
DB00744
The metabolism of Zileuton can be decreased when combined with Ticlopidine.
DB00831
The metabolism of Trifluoperazine can be decreased when combined with Ticlopidine.
DB00863
The metabolism of Ranitidine can be decreased when combined with Ticlopidine.
DB00898
The metabolism of Ethanol can be decreased when combined with Ticlopidine.
DB00934
The metabolism of Maprotiline can be decreased when combined with Ticlopidine.
DB00969
The metabolism of Alosetron can be decreased when combined with Ticlopidine.
DB00978
The metabolism of Lomefloxacin can be decreased when combined with Ticlopidine.
DB00993
The metabolism of Azathioprine can be decreased when combined with Ticlopidine.
DB00998
The metabolism of Frovatriptan can be decreased when combined with Ticlopidine.
DB01002
The metabolism of Levobupivacaine can be decreased when combined with Ticlopidine.
DB01056
The metabolism of Tocainide can be decreased when combined with Ticlopidine.
DB01065
The metabolism of Melatonin can be decreased when combined with Ticlopidine.
DB01094
The metabolism of Hesperetin can be decreased when combined with Ticlopidine.
DB01097
The metabolism of Leflunomide can be decreased when combined with Ticlopidine.
DB01115
The metabolism of Nifedipine can be decreased when combined with Ticlopidine.
DB01136
The metabolism of Carvedilol can be decreased when combined with Ticlopidine.
DB01191
The metabolism of Dexfenfluramine can be decreased when combined with Ticlopidine.
DB01405
The metabolism of Temafloxacin can be decreased when combined with Ticlopidine.
DB01558
The metabolism of Bromazepam can be decreased when combined with Ticlopidine.
DB01623
The metabolism of Thiothixene can be decreased when combined with Ticlopidine.
DB01645
The metabolism of Genistein can be decreased when combined with Ticlopidine.
DB03783
The metabolism of Phenacetin can be decreased when combined with Ticlopidine.
DB04574
The metabolism of Estrone sulfate can be decreased when combined with Ticlopidine.
DB04841
The metabolism of Flunarizine can be decreased when combined with Ticlopidine.
DB04948
The metabolism of Lofexidine can be decreased when combined with Ticlopidine.
DB04951
The metabolism of Pirfenidone can be decreased when combined with Ticlopidine.
DB06210
The metabolism of Eltrombopag can be decreased when combined with Ticlopidine.
DB06216
The metabolism of Asenapine can be decreased when combined with Ticlopidine.
DB06235
The metabolism of Vadimezan can be decreased when combined with Ticlopidine.
DB06292
The metabolism of Dapagliflozin can be decreased when combined with Ticlopidine.
DB06594
The metabolism of Agomelatine can be decreased when combined with Ticlopidine.
DB06770
The metabolism of Benzyl alcohol can be decreased when combined with Ticlopidine.
DB06774
The metabolism of Capsaicin can be decreased when combined with Ticlopidine.
DB09071
The metabolism of Tasimelteon can be decreased when combined with Ticlopidine.
DB09225
The metabolism of Zotepine can be decreased when combined with Ticlopidine.
DB09290
The metabolism of Ramosetron can be decreased when combined with Ticlopidine.
DB11967
The metabolism of Binimetinib can be decreased when combined with Ticlopidine.
DB12026
The metabolism of Voxilaprevir can be decreased when combined with Ticlopidine.
DB12945
The metabolism of Dihydralazine can be decreased when combined with Ticlopidine.
DB13953
The metabolism of Estradiol benzoate can be decreased when combined with Ticlopidine.
DB05708
The metabolism of GTS-21 can be decreased when combined with Ticlopidine.
DB00977
The metabolism of Ethinylestradiol can be decreased when combined with Ticlopidine.
DB00924
The metabolism of Cyclobenzaprine can be decreased when combined with Ticlopidine.
DB00299
The metabolism of Penciclovir can be decreased when combined with Ticlopidine.
DB00697
The metabolism of Tizanidine can be decreased when combined with Ticlopidine.
DB00773
The metabolism of Etoposide can be decreased when combined with Ticlopidine.
DB00851
The metabolism of Dacarbazine can be decreased when combined with Ticlopidine.
DB06769
The metabolism of Bendamustine can be decreased when combined with Ticlopidine.
DB08910
The metabolism of Pomalidomide can be decreased when combined with Ticlopidine.
DB00261
The metabolism of Anagrelide can be decreased when combined with Ticlopidine.
DB00177
The metabolism of Valsartan can be decreased when combined with Ticlopidine.
DB00222
The metabolism of Glimepiride can be decreased when combined with Ticlopidine.
DB00414
The metabolism of Acetohexamide can be decreased when combined with Ticlopidine.
DB00796
The metabolism of Candesartan cilexetil can be decreased when combined with Ticlopidine.
DB01120
The metabolism of Gliclazide can be decreased when combined with Ticlopidine.
DB01251
The metabolism of Gliquidone can be decreased when combined with Ticlopidine.
DB01289
The metabolism of Glisoxepide can be decreased when combined with Ticlopidine.
DB03756
The metabolism of Doconexent can be decreased when combined with Ticlopidine.
DB04557
The metabolism of Arachidonic Acid can be decreased when combined with Ticlopidine.
DB06803
The metabolism of Niclosamide can be decreased when combined with Ticlopidine.
DB08962
The metabolism of Glibornuride can be decreased when combined with Ticlopidine.
DB13406
The metabolism of Carbutamide can be decreased when combined with Ticlopidine.
DB13675
The metabolism of Metahexamide can be decreased when combined with Ticlopidine.
DB13919
The metabolism of Candesartan can be decreased when combined with Ticlopidine.
DB00250
The metabolism of Dapsone can be decreased when combined with Ticlopidine.
DB00304
The metabolism of Desogestrel can be decreased when combined with Ticlopidine.
DB00470
The metabolism of Dronabinol can be decreased when combined with Ticlopidine.
DB00471
The metabolism of Montelukast can be decreased when combined with Ticlopidine.
DB00495
The metabolism of Zidovudine can be decreased when combined with Ticlopidine.
DB00617
The metabolism of Paramethadione can be decreased when combined with Ticlopidine.
DB01198
The metabolism of Zopiclone can be decreased when combined with Ticlopidine.
DB01357
The metabolism of Mestranol can be decreased when combined with Ticlopidine.
DB01589
The metabolism of Quazepam can be decreased when combined with Ticlopidine.
DB06652
The metabolism of Vicriviroc can be decreased when combined with Ticlopidine.
DB08828
The metabolism of Vismodegib can be decreased when combined with Ticlopidine.
DB15233
The metabolism of Avapritinib can be decreased when combined with Ticlopidine.
DB01101
The metabolism of Capecitabine can be decreased when combined with Ticlopidine.
DB08875
The metabolism of Cabozantinib can be decreased when combined with Ticlopidine.
DB12147
The metabolism of Erdafitinib can be decreased when combined with Ticlopidine.
DB12371
The metabolism of Siponimod can be decreased when combined with Ticlopidine.
DB00005
The metabolism of Ticlopidine can be increased when combined with Etanercept.
DB00026
The metabolism of Ticlopidine can be increased when combined with Anakinra.
DB00051
The metabolism of Ticlopidine can be increased when combined with Adalimumab.
DB00065
The metabolism of Ticlopidine can be increased when combined with Infliximab.
DB01281
The metabolism of Ticlopidine can be increased when combined with Abatacept.
DB04956
The metabolism of Ticlopidine can be increased when combined with Afelimomab.
DB05676
The metabolism of Ticlopidine can be increased when combined with Apremilast.
DB06168
The metabolism of Ticlopidine can be increased when combined with Canakinumab.
DB06273
The metabolism of Ticlopidine can be increased when combined with Tocilizumab.
DB06372
The metabolism of Ticlopidine can be increased when combined with Rilonacept.
DB06674
The metabolism of Ticlopidine can be increased when combined with Golimumab.
DB08904
The metabolism of Ticlopidine can be increased when combined with Certolizumab pegol.
DB09029
The metabolism of Ticlopidine can be increased when combined with Secukinumab.
DB09036
The metabolism of Ticlopidine can be increased when combined with Siltuximab.
DB14724
The metabolism of Ticlopidine can be increased when combined with Emapalumab.
DB00268
The risk or severity of adverse effects can be increased when Ticlopidine is combined with Ropinirole.
DB00321
The metabolism of Amitriptyline can be decreased when combined with Ticlopidine.
DB00316
Ticlopidine may increase the hepatotoxic activities of Acetaminophen.
DB09288
Ticlopidine may increase the hepatotoxic activities of Propacetamol.
DB09539
The risk or severity of bleeding can be increased when Omega-3-acid ethyl esters is combined with Ticlopidine.
DB00945
Acetylsalicylic acid may increase the antiplatelet activities of Ticlopidine.
DB00159
The risk or severity of bleeding can be increased when Icosapent is combined with Ticlopidine.
DB00244
The risk or severity of bleeding can be increased when Mesalazine is combined with Ticlopidine.
DB00328
The risk or severity of bleeding can be increased when Indomethacin is combined with Ticlopidine.
DB00461
The risk or severity of bleeding can be increased when Nabumetone is combined with Ticlopidine.
DB00465
The risk or severity of bleeding can be increased when Ketorolac is combined with Ticlopidine.
DB00469
The risk or severity of bleeding can be increased when Tenoxicam is combined with Ticlopidine.
DB00500
The risk or severity of bleeding can be increased when Tolmetin is combined with Ticlopidine.
DB00533
The risk or severity of bleeding can be increased when Rofecoxib is combined with Ticlopidine.
DB00554
The risk or severity of bleeding can be increased when Piroxicam is combined with Ticlopidine.
DB00573
The risk or severity of bleeding can be increased when Fenoprofen is combined with Ticlopidine.
DB00580
The risk or severity of bleeding can be increased when Valdecoxib is combined with Ticlopidine.
DB00586
The risk or severity of bleeding can be increased when Diclofenac is combined with Ticlopidine.
DB00605
The risk or severity of bleeding can be increased when Sulindac is combined with Ticlopidine.
DB00712
The risk or severity of bleeding can be increased when Flurbiprofen is combined with Ticlopidine.
DB00749
The risk or severity of bleeding can be increased when Etodolac is combined with Ticlopidine.
DB00784
The risk or severity of bleeding can be increased when Mefenamic acid is combined with Ticlopidine.
DB00788
The risk or severity of bleeding can be increased when Naproxen is combined with Ticlopidine.
DB00795
The risk or severity of bleeding can be increased when Sulfasalazine is combined with Ticlopidine.
DB00812
The risk or severity of bleeding can be increased when Phenylbutazone is combined with Ticlopidine.
DB00814
The risk or severity of bleeding can be increased when Meloxicam is combined with Ticlopidine.
DB00821
The risk or severity of bleeding can be increased when Carprofen is combined with Ticlopidine.
DB00861
The risk or severity of bleeding can be increased when Diflunisal is combined with Ticlopidine.
DB00936
The risk or severity of bleeding can be increased when Salicylic acid is combined with Ticlopidine.
DB00939
The risk or severity of bleeding can be increased when Meclofenamic acid is combined with Ticlopidine.
DB00991
The risk or severity of bleeding can be increased when Oxaprozin is combined with Ticlopidine.
DB01009
The risk or severity of bleeding can be increased when Ketoprofen is combined with Ticlopidine.
DB01014
The risk or severity of bleeding can be increased when Balsalazide is combined with Ticlopidine.
DB01050
The risk or severity of bleeding can be increased when Ibuprofen is combined with Ticlopidine.
DB01250
The risk or severity of bleeding can be increased when Olsalazine is combined with Ticlopidine.
DB01283
The risk or severity of bleeding can be increased when Lumiracoxib is combined with Ticlopidine.
DB01397
The risk or severity of bleeding can be increased when Magnesium salicylate is combined with Ticlopidine.
DB01399
The risk or severity of bleeding can be increased when Salsalate is combined with Ticlopidine.
DB01401
The risk or severity of bleeding can be increased when Choline magnesium trisalicylate is combined with Ticlopidine.
DB01419
The risk or severity of bleeding can be increased when Antrafenine is combined with Ticlopidine.
DB01424
The risk or severity of bleeding can be increased when Aminophenazone is combined with Ticlopidine.
DB01435
The risk or severity of bleeding can be increased when Antipyrine is combined with Ticlopidine.
DB01600
The risk or severity of bleeding can be increased when Tiaprofenic acid is combined with Ticlopidine.
DB01628
The risk or severity of bleeding can be increased when Etoricoxib is combined with Ticlopidine.
DB02224
The risk or severity of bleeding can be increased when Taxifolin is combined with Ticlopidine.
DB03585
The risk or severity of bleeding can be increased when Oxyphenbutazone is combined with Ticlopidine.
DB04725
The risk or severity of bleeding can be increased when Licofelone is combined with Ticlopidine.
DB04743
The risk or severity of bleeding can be increased when Nimesulide is combined with Ticlopidine.
DB04812
The risk or severity of bleeding can be increased when Benoxaprofen is combined with Ticlopidine.
DB04817
The risk or severity of bleeding can be increased when Metamizole is combined with Ticlopidine.
DB04828
The risk or severity of bleeding can be increased when Zomepirac is combined with Ticlopidine.
DB05095
The risk or severity of bleeding can be increased when Cimicoxib is combined with Ticlopidine.
DB06725
The risk or severity of bleeding can be increased when Lornoxicam is combined with Ticlopidine.
DB06736
The risk or severity of bleeding can be increased when Aceclofenac is combined with Ticlopidine.
DB06737
The risk or severity of bleeding can be increased when Zaltoprofen is combined with Ticlopidine.
DB07402
The risk or severity of bleeding can be increased when Azapropazone is combined with Ticlopidine.
DB08439
The risk or severity of bleeding can be increased when Parecoxib is combined with Ticlopidine.
DB08797
The risk or severity of bleeding can be increased when Salicylamide is combined with Ticlopidine.
DB08940
The risk or severity of bleeding can be increased when Kebuzone is combined with Ticlopidine.
DB08942
The risk or severity of bleeding can be increased when Isoxicam is combined with Ticlopidine.
DB08951
The risk or severity of bleeding can be increased when Indoprofen is combined with Ticlopidine.
DB08955
The risk or severity of bleeding can be increased when Ibuproxam is combined with Ticlopidine.
DB08976
The risk or severity of bleeding can be increased when Floctafenine is combined with Ticlopidine.
DB08981
The risk or severity of bleeding can be increased when Fenbufen is combined with Ticlopidine.
DB08984
The risk or severity of bleeding can be increased when Etofenamate is combined with Ticlopidine.
DB08991
The risk or severity of bleeding can be increased when Epirizole is combined with Ticlopidine.
DB09084
The risk or severity of bleeding can be increased when Benzydamine is combined with Ticlopidine.
DB09213
The risk or severity of bleeding can be increased when Dexibuprofen is combined with Ticlopidine.
DB09214
The risk or severity of bleeding can be increased when Dexketoprofen is combined with Ticlopidine.
DB09215
The risk or severity of bleeding can be increased when Droxicam is combined with Ticlopidine.
DB09216
The risk or severity of bleeding can be increased when Tolfenamic acid is combined with Ticlopidine.
DB09217
The risk or severity of bleeding can be increased when Firocoxib is combined with Ticlopidine.
DB09218
The risk or severity of bleeding can be increased when Clonixin is combined with Ticlopidine.
DB09285
The risk or severity of bleeding can be increased when Morniflumate is combined with Ticlopidine.
DB09295
The risk or severity of bleeding can be increased when Talniflumate is combined with Ticlopidine.
DB11455
The risk or severity of bleeding can be increased when Robenacoxib is combined with Ticlopidine.
DB11466
The risk or severity of bleeding can be increased when Tepoxalin is combined with Ticlopidine.
DB11518
The risk or severity of bleeding can be increased when Flunixin is combined with Ticlopidine.
DB12399
The risk or severity of bleeding can be increased when Polmacoxib is combined with Ticlopidine.
DB12445
The risk or severity of bleeding can be increased when Nitroaspirin is combined with Ticlopidine.
DB12545
The risk or severity of bleeding can be increased when Indobufen is combined with Ticlopidine.
DB12610
The risk or severity of bleeding can be increased when Ebselen is combined with Ticlopidine.
DB13001
The risk or severity of bleeding can be increased when Tinoridine is combined with Ticlopidine.
DB13167
The risk or severity of bleeding can be increased when Alclofenac is combined with Ticlopidine.
DB13217
The risk or severity of bleeding can be increased when Fentiazac is combined with Ticlopidine.
DB13232
The risk or severity of bleeding can be increased when Suxibuzone is combined with Ticlopidine.
DB13286
The risk or severity of bleeding can be increased when Bumadizone is combined with Ticlopidine.
DB13314
The risk or severity of bleeding can be increased when Alminoprofen is combined with Ticlopidine.
DB13371
The risk or severity of bleeding can be increased when Difenpiramide is combined with Ticlopidine.
DB13407
The risk or severity of bleeding can be increased when Nifenazone is combined with Ticlopidine.
DB13432
The risk or severity of bleeding can be increased when Lonazolac is combined with Ticlopidine.
DB13481
The risk or severity of bleeding can be increased when Tenidap is combined with Ticlopidine.
DB13524
The risk or severity of bleeding can be increased when Propyphenazone is combined with Ticlopidine.
DB13527
The risk or severity of bleeding can be increased when Proglumetacin is combined with Ticlopidine.
DB13538
The risk or severity of bleeding can be increased when Guacetisal is combined with Ticlopidine.
DB13544
The risk or severity of bleeding can be increased when Ethenzamide is combined with Ticlopidine.
DB13612
The risk or severity of bleeding can be increased when Carbaspirin calcium is combined with Ticlopidine.
DB13629
The risk or severity of bleeding can be increased when Mofebutazone is combined with Ticlopidine.
DB13649
The risk or severity of bleeding can be increased when Proquazone is combined with Ticlopidine.
DB13657
The risk or severity of bleeding can be increased when Benorilate is combined with Ticlopidine.
DB13722
The risk or severity of bleeding can be increased when Pirprofen is combined with Ticlopidine.
DB13783
The risk or severity of bleeding can be increased when Acemetacin is combined with Ticlopidine.
DB13860
The risk or severity of bleeding can be increased when Imidazole salicylate is combined with Ticlopidine.
DB14059
The risk or severity of bleeding can be increased when SC-236 is combined with Ticlopidine.
DB14060
The risk or severity of bleeding can be increased when NS-398 is combined with Ticlopidine.
DB14938
The risk or severity of bleeding can be increased when Flurbiprofen axetil is combined with Ticlopidine.
DB09212
The risk or severity of bleeding can be increased when Loxoprofen is combined with Ticlopidine.
DB00373
The metabolism of Timolol can be decreased when combined with Ticlopidine.
DB00571
The serum concentration of Propranolol can be increased when it is combined with Ticlopidine.
DB00656
The risk or severity of bleeding can be increased when Trazodone is combined with Ticlopidine.
DB01175
The risk or severity of bleeding can be increased when Ticlopidine is combined with Escitalopram.
DB04855
The metabolism of Dronedarone can be decreased when combined with Ticlopidine.
DB15066
The serum concentration of Ticlopidine can be increased when it is combined with Givosiran.
DB01156
The metabolism of Bupropion can be decreased when combined with Ticlopidine.
DB06119
The serum concentration of Cenobamate can be decreased when it is combined with Ticlopidine.
DB01104
The risk or severity of bleeding can be increased when Ticlopidine is combined with Sertraline.
DB00243
The serum concentration of Ticlopidine can be increased when it is combined with Ranolazine.
DB00252
The serum concentration of Ticlopidine can be decreased when it is combined with Phenytoin.
DB01320
The serum concentration of Ticlopidine can be decreased when it is combined with Fosphenytoin.
DB00193
The metabolism of Tramadol can be decreased when combined with Ticlopidine.
DB00503
The serum concentration of Ticlopidine can be increased when it is combined with Ritonavir.
DB00502
The serum concentration of Haloperidol can be increased when it is combined with Ticlopidine.
DB11652
The metabolism of Tucatinib can be decreased when combined with Ticlopidine.
DB00472
The serum concentration of Ticlopidine can be increased when it is combined with Fluoxetine.
DB11932
The serum concentration of Ticlopidine can be increased when it is combined with Abametapir.
DB15762
The serum concentration of Ticlopidine can be decreased when it is combined with Satralizumab.

序列

实验性质

Water Solubility
Freely soluble
From Remington: The Science and Practice of Pharmacy
Melting Point
approx. 1 189°C
From Remington: The Science and Practice of Pharmacy
logP
2.9

外部标识符

resource：Drugs Product Database (DPD)
identifier：945
resource：ChEBI
identifier：9588
resource：PubChem Compound
identifier：5472
resource：PubChem Substance
identifier：46504438
resource：KEGG Compound
identifier：C07140
resource：KEGG Drug
identifier：D08594
resource：ChemSpider
identifier：5273
resource：BindingDB
identifier：85509
resource：PharmGKB
identifier：PA451686
resource：PDB
identifier：TIC
resource：Therapeutic Targets Database
identifier：DAP000723
resource：Wikipedia
identifier：Ticlopidine
resource：ChEMBL
identifier：CHEMBL833
resource：ZINC
identifier：ZINC000019594599
resource：RxCUI
identifier：10594

外部链接

RxList
http://www.rxlist.com/cgi/generic/ticlop.htm
Drugs.com
http://www.drugs.com/cdi/ticlopidine.html

路径

smpdb-id:SMP0000261
name:Ticlopidine Action Pathway
category:drug_action
drugbank-id:DB00208
name:Ticlopidine
enzymes_uniprot-id:Q9H244
smpdb-id:SMP0000611
name:Ticlopidine Metabolism Pathway
category:drug_metabolism
drugbank-id:DB00208
name:Ticlopidine
enzymes_uniprot-id:Q9H244

目标

id:BE0000110
name:P2Y purinoceptor 12
organism:Humans
action:antagonist
Storey RF: The P2Y12 receptor as a therapeutic target in cardiovascular disease. Platelets. 2001 Jun;12(4):197-209.
Boeynaems JM, van Giezen H, Savi P, Herbert JM: P2Y receptor antagonists in thrombosis. Curr Opin Investig Drugs. 2005 Mar;6(3):275-82.
Gachet C: The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther. 2005 Nov;108(2):180-92. Epub 2005 Jun 13.
Zhan C, Yang J, Dong XC, Wang YL: Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists. J Mol Graph Model. 2007 Jul;26(1):20-31. Epub 2006 Sep 26.
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
known-action:yes
name:P2Y purinoceptor 12
general-function:Guanyl-nucleotide exchange factor activity
specific-function:Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
gene-name:P2RY12
locus:3q24-q25
cellular-location:Cell membrane
transmembrane-regions:28-50 62-82 98-118 143-162 186-207 234-259 279-298
signal-regions:
theoretical-pi:9.99
molecular-weight:39438.355
chromosome-location:3
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:18124GenAtlasP2RY12GenBank Gene DatabaseAF313449GenBank Protein Database12083902IUPHAR328Guide to Pharmacology328UniProtKBQ9H244UniProt AccessionP2Y12_HUMAN
synonyms:ADP-glucose receptorADPG-RHORK3P2T(AC)P2Y(AC)P2Y(ADP)P2Y(cyc)P2Y12P2Y12 platelet ADP receptorSP1999
amino-acid-sequence:>lcl|BSEQ0009940|P2Y purinoceptor 12 MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
gene-sequence:>lcl|BSEQ0009941|P2Y purinoceptor 12 (P2RY12) ATGCAAGCCGTCGACAACCTCACCTCTGCGCCTGGTAACACCAGTCTGTGCACCAGAGAC TACAAAATCACCCAGGTCCTCTTCCCACTGCTCTACACTGTCCTGTTTTTTGTTGGACTT ATCACAAATGGCCTGGCGATGAGGATTTTCTTTCAAATCCGGAGTAAATCAAACTTTATT ATTTTTCTTAAGAACACAGTCATTTCTGATCTTCTCATGATTCTGACTTTTCCATTCAAA ATTCTTAGTGATGCCAAACTGGGAACAGGACCACTGAGAACTTTTGTGTGTCAAGTTACC TCCGTCATATTTTATTTCACAATGTATATCAGTATTTCATTCCTGGGACTGATAACTATC GATCGCTACCAGAAGACCACCAGGCCATTTAAAACATCCAACCCCAAAAATCTCTTGGGG GCTAAGATTCTCTCTGTTGTCATCTGGGCATTCATGTTCTTACTCTCTTTGCCTAACATG ATTCTGACCAACAGGCAGCCGAGAGACAAGAATGTGAAGAAATGCTCTTTCCTTAAATCA GAGTTCGGTCTAGTCTGGCATGAAATAGTAAATTACATCTGTCAAGTCATTTTCTGGATT AATTTCTTAATTGTTATTGTATGTTATACACTCATTACAAAAGAACTGTACCGGTCATAC GTAAGAACGAGGGGTGTAGGTAAAGTCCCCAGGAAAAAGGTGAACGTCAAAGTTTTCATT ATCATTGCTGTATTCTTTATTTGTTTTGTTCCTTTCCATTTTGCCCGAATTCCTTACACC CTGAGCCAAACCCGGGATGTCTTTGACTGCACTGCTGAAAATACTCTGTTCTATGTGAAA GAGAGCACTCTGTGGTTAACTTCCTTAAATGCATGCCTGGATCCGTTCATCTATTTTTTC CTTTGCAAGTCCTTCAGAAATTCCTTGATAAGTATGCTGAAGTGCCCCAATTCTGCAACA TCTCTGTCCCAGGACAATAGGAAAAAAGAACAGGATGGTGGTGACCCAAATGAAGAGACT CCAATGTAA
pfams:PF000017tm_1
go-classifiers:componentbasal plasma membranecomponentcaveolacomponentcell surfacecomponentexternal side of plasma membranecomponentintegral component of plasma membranecomponentintrinsic component of membranecomponentmitochondrioncomponentplasma membranefunctionADP receptor activityfunctionG-protein coupled adenosine receptor activityfunctionguanyl-nucleotide exchange factor activityprocessadenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayprocessblood coagulationprocesscalcium ion transmembrane transportprocesscellular response to ATPprocessG-protein coupled purinergic nucleotide receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessglial cell migrationprocesshemostasisprocessnegative regulation of cell differentiationprocessnegative regulation of norepinephrine secretionprocessplatelet activationprocessplatelet aggregationprocesspositive regulation of GTPase activityprocesspositive regulation of ion transportprocesspotassium ion transmembrane transportprocessprotein kinase B signalingprocessregulation of calcium ion transportprocessregulation of microglial cell migrationprocesssubstrate-dependent cell migration, cell extension

酶

BE0003536Cytochrome P450 2C19HumanssubstrateinhibitorA41519515014Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.A3324314563790Richter T, Murdter TE, Heinkele G, Pleiss J, Tatzel S, Schwab M, Eichelbaum M, Zanger UM: Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine. J Pharmacol Exp Ther. 2004 Jan;308(1):189-97. doi: 10.1124/jpet.103.056127. Epub 2003 Oct 16.A332479390115Donahue SR, Flockhart DA, Abernethy DR, Ko JW: Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Clin Pharmacol Ther. 1997 Nov;62(5):572-7. doi: 10.1016/S0009-9236(97)90054-0.A3324810613611Donahue S, Flockhart DA, Abernethy DR: Ticlopidine inhibits phenytoin clearance. Clin Pharmacol Ther. 1999 Dec;66(6):563-8. doi: 10.1053/cp.1999.v66.103277001.A3318011372587Giancarlo GM, Venkatakrishnan K, Granda BW, von Moltke LL, Greenblatt DJ: Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine. Eur J Clin Pharmacol. 2001 Apr;57(1):31-6.A18141210233213Tateishi T, Kumai T, Watanabe M, Nakura H, Tanaka M, Kobayashi S: Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism. Br J Clin Pharmacol. 1999 Apr;47(4):454-7. doi: 10.1046/j.1365-2125.1999.00914.x.L162Flockhart Table of Drug Interactionshttps://drug-interactions.medicine.iu.edu/Main-Table.aspxL2905Drug Interactions & Labeling - FDAhttps://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm093664.htm#table3-2L2924Ticlopidine Hydrochloride - Drug Summary - PDRhttp://www.pdr.net/drug-summary/Ticlopidine-Hydrochloride-ticlopidine-hydrochloride-3029unknownCytochrome P450 2C19Steroid hydroxylase activityResponsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.CYP2C1910q24.1-q24.3Endoplasmic reticulum membrane7.4255930.54510HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2621GenBank Gene DatabaseM61854GenBank Protein Database181344Guide to Pharmacology1328UniProtKBP33261UniProt AccessionCP2CJ_HUMAN(R)-limonene 6-monooxygenase(S)-limonene 6-monooxygenase(S)-limonene 7-monooxygenase1.14.13.-CYPIIC17CYPIIC19Cytochrome P450-11ACytochrome P450-254CMephenytoin 4-hydroxylase>lcl|BSEQ0020694|Cytochrome P450 2C19 MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP PFYQLCFIPV>lcl|BSEQ0020695|Cytochrome P450 2C19 (CYP2C19) ATGGATCCTTTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCAATCTGG AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA AATATCCTACAGATAGATATTAAGGATGTCAGCAAATCCTTAACCAATCTCTCAAAAATC TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGGAACGCATGGTGGTGCTGCATGGATAT GAAGTGGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCCATTTC CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATCGTTTTCAGCAATGGAAAGAGATGG AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG GCTTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC ATTATTTTCCAGAAACGTTTCGATTATAAAGATCAGCAATTTCTTAACTTGATGGAAAAA TTGAATGAAAACATCAGGATTGTAAGCACCCCCTGGATCCAGATATGCAATAATTTTCCC ACTATCATTGATTATTTCCCGGGAACCCATAACAAATTACTTAAAAACCTTGCTTTTATG GAAAGTGATATTTTGGAGAAAGTAAAAGAACACCAAGAATCGATGGACATCAACAACCCT CGGGACTTTATTGATTGCTTCCTGATCAAAATGGAGAAGGAAAAGCAAAACCAACAGTCT GAATTCACTATTGAAAACTTGGTAATCACTGCAGCTGACTTACTTGGAGCTGGGACAGAG ACAACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA GCTAAAGTCCAGGAAGAGATTGAACGTGTCATTGGCAGAAACCGGAGCCCCTGCATGCAG GACAGGGGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATCGAC CTCATCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACGTTAAATTCAGAAACTACCTC ATTCCCAAGGGCACAACCATATTAACTTCCCTCACTTCTGTGCTACATGACAACAAAGAA TTTCCCAACCCAGAGATGTTTGACCCTCGTCACTTTCTGGATGAAGGTGGAAATTTTAAG AAAAGTAACTACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAGGGCCTG GCCCGCATGGAGCTGTTTTTATTCCTGACCTTCATTTTACAGAACTTTAACCTGAAATCT CTGATTGACCCAAAGGACCTTGACACAACTCCTGTTGTCAATGGATTTGCTTCTGTCCCG CCCTTCTATCAGCTGTGCTTCATTCCTGTCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunction(R)-limonene 6-monooxygenase activityfunction(S)-limonene 6-monooxygenase activityfunction(S)-limonene 7-monooxygenase activityfunctionarachidonic acid epoxygenase activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessarachidonic acid metabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessheterocycle metabolic processprocessmonoterpenoid metabolic processprocessomega-hydroxylase P450 pathwayprocessoxidation-reduction processprocesssmall molecule metabolic processprocesssteroid metabolic processprocessxenobiotic metabolic processmoderateBE0002363Cytochrome P450 2D6HumanssubstrateinhibitorA41519515014Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.A3324510759690Ko JW, Desta Z, Soukhova NV, Tracy T, Flockhart DA: In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. Br J Clin Pharmacol. 2000 Apr;49(4):343-51. doi: 10.1046/j.1365-2125.2000.00175.x.A18136128496987Sasaki T, Sato Y, Kumagai T, Yoshinari K, Nagata K: Effect of health foods on cytochrome P450-mediated drug metabolism. J Pharm Health Care Sci. 2017 May 10;3:14. doi: 10.1186/s40780-017-0083-x. eCollection 2017.L162Flockhart Table of Drug Interactionshttps://drug-interactions.medicine.iu.edu/Main-Table.aspxunknownCytochrome P450 2D6Steroid hydroxylase activityResponsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.CYP2D622q13.1Endoplasmic reticulum membrane7.2655768.9422HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2625GenAtlasCYP2D6GenBank Gene DatabaseM20403GenBank Protein Database181350Guide to Pharmacology1329UniProtKBP10635UniProt AccessionCP2D6_HUMAN1.14.14.1Cholesterol 25-hydroxylaseCYP2DL1CYPIID6Cytochrome P450-DB1Debrisoquine 4-hydroxylase>lcl|BSEQ0004641|Cytochrome P450 2D6 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV FAFLVSPSPYELCAVPR>lcl|BSEQ0019275|Cytochrome P450 2D6 (CYP2D6) ATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATAGTGGCCATCTTCCTGCTCCTGGTG GACCTGATGCACCGGCGCCAACGCTGGGCTGCACGCTACCCACCAGGCCCCCTGCCACTG CCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAGAACACACCATACTGCTTCGACCAG TTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTG CTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTGACCCACGGCGAGGACACCGCCGAC CGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTCGGGCCGCGTTCCCAAGGGGTGTTC CTGGCGCGCTATGGGCCCGCGTGGCGCGAGCAGAGGCGCTTCTCCGTGTCCACCTTGCGC AACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTT TGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTTCGCCCCAACGGTCTCTTGGACAAA GCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGGCGCCGCTTCGAGTACGACGACCCT CGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGACTGAAGGAGGAGTCGGGCTTTCTG CGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCATATCCCAGCGCTGGCTGGCAAGGTC CTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGATGAGCTGCTAACTGAGCACAGGATG ACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACTGAGGCCTTCCTGGCAGAGATGGAG AAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGATGAGAACCTGCGCATAGTGGTGGCT GACCTGTTCTCTGCCGGGATGGTGACCACCTCGACCACGCTGGCCTGGGGCCTCCTGCTC ATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAACAGGAGATCGACGACGTGATAGGG CAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCACATGCCCTACACCACTGCCGTGATT CATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTGGGTGTGACCCATATGACATCCCGT GACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGAACGACACTCATCACCAACCTGTCA TCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCCTTCCGCTTCCACCCCGAACACTTC CTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCCTTCCTGCCTTTCTCAGCAGGCCGC CGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAGCTCTTCCTCTTCTTCACCTCCCTG CTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAGCCCCGGCCCAGCCACCATGGTGTC TTTGCTTTCCTGGTGAGCCCATCCCCCTATGAGCTTTGTGCTGTGCCCCGCTAGPF00067p450componentcytoplasmcomponentendoplasmic reticulumcomponentendoplasmic reticulum membranecomponentmitochondrionfunctionarachidonic acid epoxygenase activityfunctionaromatase activityfunctiondrug bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessalkaloid catabolic processprocessalkaloid metabolic processprocessarachidonic acid metabolic processprocesscoumarin metabolic processprocessdrug catabolic processprocessdrug metabolic processprocessexogenous drug catabolic processprocessheterocycle metabolic processprocessisoquinoline alkaloid metabolic processprocessmonoterpenoid metabolic processprocessnegative regulation of bindingprocessnegative regulation of cellular organofluorine metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid metabolic processprocessxenobiotic metabolic processunknownBE0001075MyeloperoxidaseHumanssubstrateA41519515014Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1.unknownMyeloperoxidasePeroxidase activityPart of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.MPO17q23.1Lysosome1-489.1483867.7117HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:7218GenAtlasMPOGenBank Gene DatabaseJ02694GenBank Protein Database189040Guide to Pharmacology2789UniProtKBP05164UniProt AccessionPERM_HUMAN1.11.2.2MPO>lcl|BSEQ0002139|Myeloperoxidase MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS NSYPRDFVNCSTLPALNLASWREAS>lcl|BSEQ0016304|Myeloperoxidase (MPO) ATGGGGGTTCCCTTCTTCTCTTCTCTCAGATGCATGGTGGACTTAGGACCTTGCTGGGCT GGGGGTCTCACTGCAGAGATGAAGCTGCTTCTGGCCCTAGCAGGGCTCCTGGCCATTCTG GCCACGCCCCAGCCCTCTGAAGGTGCTGCTCCAGCTGTCCTGGGGGAGGTGGACACCTCG TTGGTGCTGAGCTCCATGGAGGAGGCCAAGCAGCTGGTGGACAAGGCCTACAAGGAGCGG CGGGAAAGCATCAAGCAGCGGCTTCGCAGCGGCTCAGCCAGCCCCATGGAACTCCTATCC TACTTCAAGCAGCCGGTGGCAGCCACCAGGACGGCGGTGAGGGCCGCTGACTACCTGCAC GTGGCTCTAGACCTGCTGGAGAGGAAGCTGCGGTCCCTGTGGCGAAGGCCATTCAATGTC ACTGATGTGCTGACGCCCGCCCAGCTGAATGTGTTGTCCAAGTCAAGCGGCTGCGCCTAC CAGGACGTGGGGGTGACTTGCCCGGAGCAGGACAAATACCGCACCATCACCGGGATGTGC AACAACAGACGCAGCCCCACGCTGGGGGCCTCCAACCGTGCCTTTGTGCGCTGGCTGCCG GCGGAGTATGAGGACGGCTTCTCTCTTCCCTACGGCTGGACGCCCGGGGTCAAGCGCAAC GGCTTCCCGGTGGCTCTGGCTCGCGCGGTCTCCAACGAGATCGTGCGCTTCCCCACTGAT CAGCTGACTCCGGACCAGGAGCGCTCACTCATGTTCATGCAATGGGGCCAGCTGTTGGAC CACGACCTCGACTTCACCCCTGAGCCGGCCGCCCGGGCCTCCTTCGTCACTGGCGTCAAC TGCGAGACCAGCTGCGTTCAGCAGCCGCCCTGCTTCCCGCTCAAGATCCCGCCCAATGAC CCCCGCATCAAGAACCAAGCCGACTGCATCCCGTTCTTCCGCTCCTGCCCGGCTTGCCCC GGGAGCAACATCACCATCCGCAACCAGATCAACGCGCTCACTTCCTTCGTGGACGCCAGC ATGGTGTACGGCAGCGAGGAGCCCCTGGCCAGGAACCTGCGCAACATGTCCAACCAGCTG GGGCTGCTGGCCGTCAACCAGCGCTTCCAAGACAACGGCCGGGCCCTGCTGCCCTTTGAC AACCTGCACGATGACCCCTGTCTCCTCACCAACCGCTCAGCGCGCATCCCCTGCTTCCTG GCAGGGGACACCCGTTCCAGTGAGATGCCCGAGCTCACCTCCATGCACACCCTCTTACTT CGGGAGCACAACCGGCTGGCCACAGAGCTCAAGAGCCTGAACCCTAGGTGGGATGGGGAG AGGCTCTACCAGGAAGCCCGGAAGATCGTGGGGGCCATGGTCCAGATCATCACTTACCGG GACTACCTGCCCCTGGTGCTGGGGCCAACGGCCATGAGGAAGTACCTGCCCACGTACCGT TCCTACAATGACTCAGTGGACCCACGCATCGCCAACGTCTTCACCAATGCCTTCCGCTAC GGCCACACCCTCATCCAACCCTTCATGTTCCGCCTGGACAATCGGTACCAGCCCATGGAA CCCAACCCCCGTGTCCCCCTCAGCAGGGTCTTTTTTGCCTCCTGGAGGGTCGTGCTGGAA GGTGGCATTGACCCCATCCTCCGGGGCCTCATGGCCACCCCTGCCAAGCTGAATCGTCAG AACCAAATTGCAGTGGATGAGATCCGGGAGCGATTGTTTGAGCAGGTCATGAGGATTGGG CTGGACCTGCCTGCTCTGAACATGCAGCGCAGCAGGGACCACGGCCTCCCAGGATACAAT GCCTGGAGGCGCTTCTGTGGGCTCCCGCAGCCTGAAACTGTGGGCCAGCTGGGCACGGTG CTGAGGAACCTGAAATTGGCGAGGAAACTGATGGAGCAGTATGGCACGCCCAACAACATC GACATCTGGATGGGCGGCGTGTCCGAGCCTCTGAAGCGCAAAGGCCGCGTGGGCCCACTC CTCGCCTGCATCATCGGTACCCAGTTCAGGAAGCTCCGGGATGGTGATCGGTTTTGGTGG GAGAACGAGGGTGTGTTCAGCATGCAGCAGCGACAGGCCCTGGCCCAGATCTCATTGCCC CGGATCATCTGCGACAACACAGGCATCACCACCGTGTCTAAGAACAACATCTTCATGTCC AACTCATATCCCCGGGACTTTGTCAACTGCAGTACACTTCCTGCATTGAACCTGGCTTCC TGGAGGGAAGCCTCCTAGPF03098An_peroxidasecomponentazurophil granulecomponentextracellular exosomecomponentextracellular spacecomponentlysosomecomponentmitochondrioncomponentnucleuscomponentsecretory granulefunctionchromatin bindingfunctionheme bindingfunctionheparin bindingfunctionmetal ion bindingfunctionperoxidase activityprocessdefense responseprocessdefense response to fungusprocesshydrogen peroxide catabolic processprocesshypochlorous acid biosynthetic processprocesslow-density lipoprotein particle remodelingprocessnegative regulation of apoptotic processprocessnegative regulation of growth of symbiont in hostprocessoxidation-reduction processprocessremoval of superoxide radicalsprocessrespiratory burst involved in defense responseprocessresponse to oxidative stressprocessresponse to yeastBE0002793Cytochrome P450 2C9HumansinhibitorA3318011372587Giancarlo GM, Venkatakrishnan K, Granda BW, von Moltke LL, Greenblatt DJ: Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine. Eur J Clin Pharmacol. 2001 Apr;57(1):31-6.A332479390115Donahue SR, Flockhart DA, Abernethy DR, Ko JW: Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19. Clin Pharmacol Ther. 1997 Nov;62(5):572-7. doi: 10.1016/S0009-9236(97)90054-0.A3937821666702Yang SH, Cho YA, Choi JS: Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats. Acta Pharmacol Sin. 2011 Jul;32(7):967-72. doi: 10.1038/aps.2011.32. Epub 2011 Jun 13.unknownCytochrome P450 2C9Steroid hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.CYP2C910q24Endoplasmic reticulum membrane7.9955627.36510HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2623GenAtlasCYP2C9GenBank Gene DatabaseAY341248Guide to Pharmacology1326UniProtKBP11712UniProt AccessionCP2C9_HUMAN(R)-limonene 6-monooxygenase(S)-limonene 6-monooxygenase(S)-limonene 7-monooxygenase1.14.13.-Cholesterol 25-hydroxylaseCYP2C10CYPIIC9Cytochrome P-450MPCytochrome P450 MP-4Cytochrome P450 MP-8Cytochrome P450 PB-1S-mephenytoin 4-hydroxylase>lcl|BSEQ0005471|Cytochrome P450 2C9 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP PFYQLCFIPV>lcl|BSEQ0016893|Cytochrome P450 2C9 (CYP2C9) ATGGATTCTCTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCACTCTGG AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA AATATCCTACAGATAGGTATTAAGGACATCAGCAAATCCTTAACCAATCTCTCAAAGGTC TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGCTGCATGGATAT GAAGCAGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCATTTTC CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGG AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG GCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC ATTATTTTCCATAAACGTTTTGATTATAAAGATCAGCAATTTCTTAACTTAATGGAAAAG TTGAATGAAAACATCAAGATTTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCT CCTATCATTGATTACTTCCCGGGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATG AAAAGTTATATTTTGGAAAAAGTAAAAGAACACCAAGAATCAATGGACATGAACAACCCT CAGGACTTTATTGATTGCTTCCTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCT GAATTTACTATTGAAAGCTTGGAAAACACTGCAGTTGACTTGTTTGGAGCTGGGACAGAG ACGACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA GCTAAAGTCCAGGAAGAGATTGAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAA GACAGGAGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATTGAC CTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTCAGAAACTATCTC ATTCCCAAGGGCACAACCATATTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAA TTTCCCAACCCAGAGATGTTTGACCCTCATCACTTTCTGGATGAAGGTGGCAATTTTAAG AAAAGTAAATACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTG GCCGGCATGGAGCTGTTTTTATTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCT CTGGTTGACCCAAAGAACCTTGACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCG CCCTTCTACCAGCTGTGCTTCATTCCTGTCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunction(R)-limonene 6-monooxygenase activityfunction(S)-limonene 6-monooxygenase activityfunction(S)-limonene 7-monooxygenase activityfunctionarachidonic acid epoxygenase activityfunctionaromatase activityfunctioncaffeine oxidase activityfunctiondrug bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessarachidonic acid metabolic processprocesscellular amide metabolic processprocessdrug catabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessmonocarboxylic acid metabolic processprocessmonoterpenoid metabolic processprocessomega-hydroxylase P450 pathwayprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid metabolic processprocessurea metabolic processprocessxenobiotic metabolic processweakBE0002887Cytochrome P450 2C8HumansinhibitorA3811226721703Backman JT, Filppula AM, Niemi M, Neuvonen PJ: Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. doi: 10.1124/pr.115.011411.unknownCytochrome P450 2C8Steroid hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).CYP2C810q23.33Endoplasmic reticulum membrane8.6255824.27510HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2622GenAtlasCYP2C8GenBank Gene DatabaseM17397Guide to Pharmacology1325UniProtKBP10632UniProt AccessionCP2C8_HUMAN1.14.14.1CYPIIC8Cytochrome P450 form 1Cytochrome P450 IIC2Cytochrome P450 MP-12Cytochrome P450 MP-20S-mephenytoin 4-hydroxylase>lcl|BSEQ0005650|Cytochrome P450 2C8 MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP PSYQICFIPV>lcl|BSEQ0021338|Cytochrome P450 2C8 (CYP2C8) ATGGAACCTTTTGTGGTCCTGGTGCTGTGTCTCTCTTTTATGCTTCTCTTTTCACTCTGG AGACAGAGCTGTAGGAGAAGGAAGCTCCCTCCTGGCCCCACTCCTCTTCCTATTATTGGA AATATGCTACAGATAGATGTTAAGGACATCTGCAAATCTTTCACCAATTTCTCAAAAGTC TATGGTCCTGTGTTCACCGTGTATTTTGGCATGAATCCCATAGTGGTGTTTCATGGATAT GAGGCAGTGAAGGAAGCCCTGATTGATAATGGAGAGGAGTTTTCTGGAAGAGGCAATTCC CCAATATCTCAAAGAATTACTAAAGGACTTGGAATCATTTCCAGCAATGGAAAGAGATGG AAGGAGATCCGGCGTTTCTCCCTCACAACCTTGCGGAATTTTGGGATGGGGAAGAGGAGC ATTGAGGACCGTGTTCAAGAGGAAGCTCACTGCCTTGTGGAGGAGTTGAGAAAAACCAAG GCTTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC GTTGTTTTCCAGAAACGATTTGATTATAAAGATCAGAATTTTCTCACCCTGATGAAAAGA TTCAATGAAAACTTCAGGATTCTGAACTCCCCATGGATCCAGGTCTGCAATAATTTCCCT CTACTCATTGATTGTTTCCCAGGAACTCACAACAAAGTGCTTAAAAATGTTGCTCTTACA CGAAGTTACATTAGGGAGAAAGTAAAAGAACACCAAGCATCACTGGATGTTAACAATCCT CGGGACTTTATCGATTGCTTCCTGATCAAAATGGAGCAGGAAAAGGACAACCAAAAGTCA GAATTCAATATTGAAAACTTGGTTGGCACTGTAGCTGATCTATTTGTTGCTGGAACAGAG ACAACAAGCACCACTCTGAGATATGGACTCCTGCTCCTGCTGAAGCACCCAGAGGTCACA GCTAAAGTCCAGGAAGAGATTGATCATGTAATTGGCAGACACAGGAGCCCCTGCATGCAG GATAGGAGCCACATGCCTTACACTGATGCTGTAGTGCACGAGATCCAGAGATACAGTGAC CTTGTCCCCACCGGTGTGCCCCATGCAGTGACCACTGATACTAAGTTCAGAAACTACCTC ATCCCCAAGGGCACAACCATAATGGCATTACTGACTTCCGTGCTACATGATGACAAAGAA TTTCCTAATCCAAATATCTTTGACCCTGGCCACTTTCTAGATAAGAATGGCAACTTTAAG AAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAAACGAATTTGTGCAGGAGAAGGACTT GCCCGCATGGAGCTATTTTTATTTCTAACCACAATTTTACAGAACTTTAACCTGAAATCT GTTGATGATTTAAAGAACCTCAATACTACTGCAGTTACCAAAGGGATTGTTTCTCTGCCA CCCTCATACCAGATCTGCTTCATCCCTGTCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunctionarachidonic acid epoxygenase activityfunctionaromatase activityfunctioncaffeine oxidase activityfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessarachidonic acid metabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessomega-hydroxylase P450 pathwayprocessorganic acid metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocessxenobiotic metabolic processweakBE0002433Cytochrome P450 1A2HumansinhibitorA3324314563790Richter T, Murdter TE, Heinkele G, Pleiss J, Tatzel S, Schwab M, Eichelbaum M, Zanger UM: Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine. J Pharmacol Exp Ther. 2004 Jan;308(1):189-97. doi: 10.1124/jpet.103.056127. Epub 2003 Oct 16.A3327817403206Aleil B, Rochoux G, Monassier JP, Cazenave JP, Gachet C: Ticlopidine could be an alternative therapy in the case of pharmacological resistance to clopidogrel: a report of three cases. J Thromb Haemost. 2007 Apr;5(4):879-81. doi: 10.1111/j.1538-7836.2007.02338.x.A1481311996015Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.A3324510759690Ko JW, Desta Z, Soukhova NV, Tracy T, Flockhart DA: In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. Br J Clin Pharmacol. 2000 Apr;49(4):343-51. doi: 10.1046/j.1365-2125.2000.00175.x.L162Flockhart Table of Drug Interactionshttps://drug-interactions.medicine.iu.edu/Main-Table.aspxL2924Ticlopidine Hydrochloride - Drug Summary - PDRhttp://www.pdr.net/drug-summary/Ticlopidine-Hydrochloride-ticlopidine-hydrochloride-3029unknownCytochrome P450 1A2Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.CYP1A215q24Endoplasmic reticulum membrane9.4358293.7615HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2596GenAtlasCYP1A2GenBank Gene DatabaseZ00036Guide to Pharmacology1319UniProtKBP05177UniProt AccessionCP1A2_HUMAN1.14.14.1Cholesterol 25-hydroxylaseCYPIA2Cytochrome P(3)450Cytochrome P450 4Cytochrome P450-P3>lcl|BSEQ0004778|Cytochrome P450 1A2 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE FSVPPGVKVDLTPIYGLTMKHARCEHVQARRFSIN>lcl|BSEQ0011742|Cytochrome P450 1A2 (CYP1A2) ATGGCATTGTCCCAGTCTGTTCCCTTCTCGGCCACAGAGCTTCTCCTGGCCTCTGCCATC TTCTGCCTGGTATTCTGGGTGCTCAAGGGTTTGAGGCCTCGGGTCCCCAAAGGCCTGAAA AGTCCACCAGAGCCATGGGGCTGGCCCTTGCTCGGGCATGTGCTGACCCTGGGGAAGAAC CCGCACCTGGCACTGTCAAGGATGAGCCAGCGCTACGGGGACGTCCTGCAGATCCGCATT GGCTCCACGCCCGTGCTGGTGCTGAGCCGCCTGGACACCATCCGGCAGGCCCTGGTGCGG CAGGGCGACGATTTCAAGGGCCGGCCTGACCTCTACACCTCCACCCTCATCACTGATGGC CAGAGCTTGACCTTCAGCACAGACTCTGGACCGGTGTGGGCTGCCCGCCGGCGCCTGGCC CAGAATGCCCTCAACACCTTCTCCATCGCCTCTGACCCAGCTTCCTCATCCTCCTGCTAC CTGGAGGAGCATGTGAGCAAGGAGGCTAAGGCCCTGATCAGCAGGTTGCAGGAGCTGATG GCAGGGCCTGGGCACTTCGACCCTTACAATCAGGTGGTGGTGTCAGTGGCCAACGTCATT GGTGCCATGTGCTTCGGACAGCACTTCCCTGAGAGTAGCGATGAGATGCTCAGCCTCGTG AAGAACACTCATGAGTTCGTGGAGACTGCCTCCTCCGGGAACCCCCTGGACTTCTTCCCC ATCCTTCGCTACCTGCCTAACCCTGCCCTGCAGAGGTTCAAGGCCTTCAACCAGAGGTTC CTGTGGTTCCTGCAGAAAACAGTCCAGGAGCACTATCAGGACTTTGACAAGAACAGTGTC CGGGACATCACGGGTGCCCTGTTCAAGCACAGCAAGAAGGGGCCTAGAGCCAGCGGCAAC CTCATCCCACAGGAGAAGATTGTCAACCTTGTCAATGACATCTTTGGAGCAGGATTTGAC ACAGTCACCACAGCCATCTCCTGGAGCCTCATGTACCTTGTGACCAAGCCTGAGATACAG AGGAAGATCCAGAAGGAGCTGGACACTGTGATTGGCAGGGAGCGGCGGCCCCGGCTCTCT GACAGACCCCAGCTGCCCTACTTGGAGGCCTTCATCCTGGAGACCTTCCGACACTCCTCC TTCTTGCCCTTCACCATCCCCCACAGCACAACAAGGGACACAACGCTGAATGGCTTCTAC ATCCCCAAGAAATGCTGTGTCTTCGTAAACCAGTGGCAGGTCAACCATGACCCAGAGCTG TGGGAGGACCCCTCTGAGTTCCGGCCTGAGCGGTTCCTCACCGCCGATGGCACTGCCATT AACAAGCCCTTGAGTGAGAAGATGATGCTGTTTGGCATGGGCAAGCGCCGGTGTATCGGG GAAGTCCTGGCCAAGTGGGAGATCTTCCTCTTCCTGGCCATCCTGCTACAGCAACTGGAG TTCAGCGTGCCGCCGGGCGTGAAAGTCGACCTGACCCCCATCTACGGGCTGACCATGAAG CACGCCCGCTGTGAACATGTCCAGGCGCGGCTGCGCTTCTCCATCAATTGAPF00067p450componentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunctionaromatase activityfunctioncaffeine oxidase activityfunctiondemethylase activityfunctionelectron carrier activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenprocessalkaloid metabolic processprocessarachidonic acid metabolic processprocesscellular respirationprocesscellular response to cadmium ionprocessdibenzo-p-dioxin metabolic processprocessdrug catabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessheterocycle metabolic processprocesshydrogen peroxide biosynthetic processprocesslung developmentprocessmethylationprocessmonocarboxylic acid metabolic processprocessmonoterpenoid metabolic processprocessomega-hydroxylase P450 pathwayprocessoxidation-reduction processprocessoxidative deethylationprocessoxidative demethylationprocessporphyrin-containing compound metabolic processprocesspost-embryonic developmentprocessregulation of gene expressionprocessresponse to estradiolprocessresponse to immobilization stressprocessresponse to lipopolysaccharideprocesssmall molecule metabolic processprocesssteroid catabolic processprocesstoxin biosynthetic processprocessxenobiotic metabolic processunknownBE0003549Cytochrome P450 2B6HumansinhibitorA1485417101742Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38.A3324314563790Richter T, Murdter TE, Heinkele G, Pleiss J, Tatzel S, Schwab M, Eichelbaum M, Zanger UM: Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine. J Pharmacol Exp Ther. 2004 Jan;308(1):189-97. doi: 10.1124/jpet.103.056127. Epub 2003 Oct 16.L162Flockhart Table of Drug Interactionshttps://drug-interactions.medicine.iu.edu/Main-Table.aspxL2924Ticlopidine Hydrochloride - Drug Summary - PDRhttp://www.pdr.net/drug-summary/Ticlopidine-Hydrochloride-ticlopidine-hydrochloride-3029unknownCytochrome P450 2B6Steroid hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.CYP2B619q13.2Endoplasmic reticulum membrane8.4456277.8119HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2615GenBank Gene DatabaseM29874GenBank Protein Database181296Guide to Pharmacology1324UniProtKBP20813UniProt AccessionCP2B6_HUMAN1,4-cineole 2-exo-monooxygenase1.14.13.-CYPIIB6Cytochrome P450 IIB1>lcl|BSEQ0006839|Cytochrome P450 2B6 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI PPTYQIRFLPR>lcl|BSEQ0019435|Cytochrome P450 2B6 (CYP2B6) ATGGAACTCAGCGTCCTCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCCTGGTT CAGCGCCACCCTAACACCCATGACCGCCTCCCACCAGGGCCCCGCCCTCTGCCCCTTTTG GGAAACCTTCTGCAGATGGATAGAAGAGGCCTACTCAAATCCTTTCTGAGGTTCCGAGAG AAATATGGGGACGTCTTCACGGTACACCTGGGACCGAGGCCCGTGGTCATGCTGTGTGGA GTAGAGGCCATACGGGAGGCCCTTGTGGACAAGGCTGAGGCCTTCTCTGGCCGGGGAAAA ATCGCCATGGTCGACCCATTCTTCCGGGGATATGGTGTGATCTTTGCCAATGGAAACCGC TGGAAGGTGCTTCGGCGATTCTCTGTGACCACTATGAGGGACTTCGGGATGGGAAAGCGG AGTGTGGAGGAGCGGATTCAGGAGGAGGCTCAGTGTCTGATAGAGGAGCTTCGGAAATCC AAGGGGGCCCTCATGGACCCCACCTTCCTCTTCCAGTCCATTACCGCCAACATCATCTGC TCCATCGTCTTTGGAAAACGATTCCACTACCAAGATCAAGAGTTCCTGAAGATGCTGAAC TTGTTCTACCAGACTTTTTCACTCATCAGCTCTGTATTCGGCCAGCTGTTTGAGCTCTTC TCTGGCTTCTTGAAATACTTTCCTGGGGCACACAGGCAAGTTTACAAAAACCTGCAGGAA ATCAATGCTTACATTGGCCACAGTGTGGAGAAGCACCGTGAAACCCTGGACCCCAGCGCC CCCAAGGACCTCATCGACACCTACCTGCTCCACATGGAAAAAGAGAAATCCAACGCACAC AGTGAATTCAGCCACCAGAACCTCAACCTCAACACGCTCTCGCTCTTCTTTGCTGGCACT GAGACCACCAGCACCACTCTCCGCTACGGCTTCCTGCTCATGCTCAAATACCCTCATGTT GCAGAGAGAGTCTACAGGGAGATTGAACAGGTGATTGGCCCACATCGCCCTCCAGAGCTT CATGACCGAGCCAAAATGCCATACACAGAGGCAGTCATCTATGAGATTCAGAGATTTTCC GACCTTCTCCCCATGGGTGTGCCCCACATTGTCACCCAACACACCAGCTTCCGAGGGTAC ATCATCCCCAAGGACACAGAAGTATTTCTCATCCTGAGCACTGCTCTCCATGACCCACAC TACTTTGAAAAACCAGACGCCTTCAATCCTGACCACTTTCTGGATGCCAATGGGGCACTG AAAAAGACTGAAGCTTTTATCCCCTTCTCCTTAGGGAAGCGGATTTGTCTTGGTGAAGGC ATCGCCCGTGCGGAATTGTTCCTCTTCTTCACCACCATCCTCCAGAACTTCTCCATGGCC AGCCCCGTGGCCCCAGAAGACATCGATCTGACACCCCAGGAGTGTGGTGTGGGCAAAATA CCCCCAACATACCAGATCCGCTTCCTGCCCCGCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunctionarachidonic acid epoxygenase activityfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocesscellular ketone metabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessoxidation-reduction processprocesssmall molecule metabolic processprocesssteroid metabolic processprocessxenobiotic metabolic processmoderateBE0003533Cytochrome P450 2E1HumansinhibitorA3324510759690Ko JW, Desta Z, Soukhova NV, Tracy T, Flockhart DA: In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6. Br J Clin Pharmacol. 2000 Apr;49(4):343-51. doi: 10.1046/j.1365-2125.2000.00175.x.unknownCytochrome P450 2E1Steroid hydroxylase activityMetabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.CYP2E110q24.3-qterEndoplasmic reticulum membrane8.2256848.4210HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2631GenBank Gene DatabaseJ02625GenBank Protein Database181360Guide to Pharmacology1330UniProtKBP05181UniProt AccessionCP2E1_HUMAN1.14.13.-4-nitrophenol 2-hydroxylaseCYP2ECYPIIE1Cytochrome P450-J>lcl|BSEQ0012460|Cytochrome P450 2E1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC IPPRYKLCVIPRS>lcl|BSEQ0012461|Cytochrome P450 2E1 (CYP2E1) ATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTG TCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCC ATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGTTG GCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATG CACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGA GGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGAATCATTTTTAATAATGGACCT ACCTGGAAGGACATCCGGCGGTTTTCCCTGACCACCCTCCGGAACTATGGGATGGGGAAA CAGGGCAATGAGAGCCGGATCCAGAGGGAGGCCCACTTCCTGCTGGAAGCACTCAGGAAG ACCCAAGGCCAGCCTTTCGACCCCACCTTCCTCATCGGCTGCGCGCCCTGCAACGTCATA GCCGACATCCTCTTCCGCAAGCATTTTGACTACAATGATGAGAAGTTTCTAAGGCTGATG TATTTGTTTAATGAGAACTTCCACCTACTCAGCACTCCCTGGCTCCAGCTTTACAATAAT TTTCCCAGCTTTCTACACTACTTGCCTGGAAGCCACAGAAAAGTCATAAAAAATGTGGCT GAAGTAAAAGAGTATGTGTCTGAAAGGGTGAAGGAGCACCATCAATCTCTGGACCCCAAC TGTCCCCGGGACCTCACCGACTGCCTGCTCGTGGAAATGGAGAAGGAAAAGCACAGTGCA GAGCGCTTGTACACAATGGACGGTATCACCGTGACTGTGGCCGACCTGTTCTTTGCGGGG ACAGAGACCACCAGCACAACTCTGAGATATGGGCTCCTGATTCTCATGAAATACCCTGAG ATCGAAGAGAAGCTCCATGAAGAAATTGACAGGGTGATTGGGCCAAGCCGAATCCCTGCC ATCAAGGATAGGCAAGAGATGCCCTACATGGATGCTGTGGTGCATGAGATTCAGCGGTTC ATCACCCTCGTGCCCTCCAACCTGCCCCATGAAGCAACCCGAGACACCATTTTCAGAGGA TACCTCATCCCCAAGGGCACAGTCGTAGTGCCAACTCTGGACTCTGTTTTGTATGACAAC CAAGAATTTCCTGATCCAGAAAAGTTTAAGCCAGAACACTTCCTGAATGAAAATGGAAAG TTCAAGTACAGTGACTATTTCAAGCCATTTTCCACAGGAAAACGAGTGTGTGCTGGAGAA GGCCTGGCTCGCATGGAGTTGTTTCTTTTGTTGTGTGCCATTTTGCAGCATTTTAATTTG AAGCCTCTCGTTGACCCAAAGGATATCGACCTCAGCCCTATACATATTGGGTTTGGCTGT ATCCCACCACGTTACAAACTCTGTGTCATTCCCCGCTCATGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentGolgi membranecomponentintracellular membrane-bounded organellecomponentintrinsic component of endoplasmic reticulum membranecomponentmitochondrionfunctionarachidonic acid epoxygenase activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessheterocycle metabolic processprocessmonoterpenoid metabolic processprocessoxidation-reduction processprocessresponse to ethanolprocessresponse to organonitrogen compoundprocessresponse to ozoneprocesssmall molecule metabolic processprocesssteroid metabolic processprocesstriglyceride metabolic processprocessxenobiotic metabolic processweak

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运输工具

药物反应

reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00091
right-element--name:2-Chloroticlopidine
enzymes--drugbank-id:BE0001075
enzymes--name:Myeloperoxidase
enzymes--uniprot-id:P05164
reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00092
right-element--name:2-Oxoticlopidine
enzymes--drugbank-id:BE0002638
enzymes--name:Cytochrome P450 3A4
enzymes--uniprot-id:P08684
enzymes--drugbank-id:BE0003536
enzymes--name:Cytochrome P450 2C19
enzymes--uniprot-id:P33261
reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00093
right-element--name:Thienodihydropyridinium
enzymes--drugbank-id:BE0001075
enzymes--name:Myeloperoxidase
enzymes--uniprot-id:P05164
enzymes--drugbank-id:BE0002638
enzymes--name:Cytochrome P450 3A4
enzymes--uniprot-id:P08684
enzymes--drugbank-id:BE0003536
enzymes--name:Cytochrome P450 2C19
enzymes--uniprot-id:P33261
reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00094
right-element--name:Ticlopidine S-oxide
enzymes--drugbank-id:BE0003536
enzymes--name:Cytochrome P450 2C19
enzymes--uniprot-id:P33261
enzymes--drugbank-id:BE0002363
enzymes--name:Cytochrome P450 2D6
enzymes--uniprot-id:P10635
reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00095
right-element--name:Dehydrogenated ticlopidine
enzymes--drugbank-id:BE0001075
enzymes--name:Myeloperoxidase
enzymes--uniprot-id:P05164
reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00096
right-element--name:Ticlopidine N-oxide
enzymes--drugbank-id:BE0001075
enzymes--name:Myeloperoxidase
enzymes--uniprot-id:P05164
reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00097
right-element--name:di-Hydroxyticlopidine
enzymes--drugbank-id:BE0003536
enzymes--name:Cytochrome P450 2C19
enzymes--uniprot-id:P33261
reactions:1
left-element--drugbank-id:DB00208
left-element--name:Ticlopidine
right-element--drugbank-id:DBMET00618
right-element--name:7-Hydroxyticlopidine
reactions:2
left-element--drugbank-id:DBMET00092
left-element--name:2-Oxoticlopidine
right-element--drugbank-id:DBMET01202
right-element--name:Active metabolite of Ticlopidine
reactions:2
left-element--drugbank-id:DBMET00094
left-element--name:Ticlopidine S-oxide
right-element--drugbank-id:DBMET01207
right-element--name:Ticlopidine S-oxide dimer
reactions:2
left-element--drugbank-id:DBMET00093
left-element--name:Thienodihydropyridinium
right-element--drugbank-id:DBMET01208
right-element--name:Thienopyridinium
enzymes--drugbank-id:BE0002638
enzymes--name:Cytochrome P450 3A4
enzymes--uniprot-id:P08684
enzymes--drugbank-id:BE0003536
enzymes--name:Cytochrome P450 2C19
enzymes--uniprot-id:P33261
enzymes--drugbank-id:BE0001075
enzymes--name:Myeloperoxidase
enzymes--uniprot-id:P05164
reactions:2
left-element--drugbank-id:DBMET00093
left-element--name:Thienodihydropyridinium
right-element--drugbank-id:DBMET01209
right-element--name:Ticlopidine lactam analog (M8)
enzymes--drugbank-id:BE0002638
enzymes--name:Cytochrome P450 3A4
enzymes--uniprot-id:P08684

效应

不良反应