ID

DB00209|APRD00393||

名称

Trospium

描述

Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.[L6208] An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination.[L6208] Trospium is manufactured by _Indevus Pharmaceutical Inc._ and was granted FDA approval in 2007.[L6211]

cas号

47608-32-2

唯一标识码

T4Y8ORK057

状态

solid

组

approved,

指示

For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.

药效学

Trospium is an antispasmodic, antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. According to receptor assays, it displays higher affinity towards muscarininc receptors compared to nicotinic receptors at therapeutic concentrations.

作用机制

Trospium antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder.

毒性

代谢

Not fully defined

吸收

9.6%

半衰期

20 hours

分类

description:This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
direct-parent:Diphenylmethanes
kingdom:Organic compounds
superclass:Benzenoids
class:Benzene and substituted derivatives
subclass:Diphenylmethanes
alternative-parent:Amines
alternative-parent:Aromatic alcohols
alternative-parent:Azacyclic compounds
alternative-parent:Carbonyl compounds
alternative-parent:Carboxylic acid esters
alternative-parent:Hydrocarbon derivatives
alternative-parent:Monocarboxylic acids and derivatives
alternative-parent:N-alkylpyrrolidines
alternative-parent:Organic cations
alternative-parent:Organic oxides
alternative-parent:Organic salts
alternative-parent:Organopnictogen compounds
alternative-parent:Piperidines
alternative-parent:Tertiary alcohols
alternative-parent:Tetraalkylammonium salts
substituent:Alcohol
substituent:Amine
substituent:Aromatic alcohol
substituent:Aromatic heteropolycyclic compound
substituent:Azacycle
substituent:Carbonyl group
substituent:Carboxylic acid derivative
substituent:Carboxylic acid ester
substituent:Diphenylmethane
substituent:Hydrocarbon derivative
substituent:Monocarboxylic acid or derivatives
substituent:N-alkylpyrrolidine
substituent:Organic cation
substituent:Organic nitrogen compound
substituent:Organic oxide
substituent:Organic oxygen compound
substituent:Organic salt
substituent:Organoheterocyclic compound
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound
substituent:Piperidine
substituent:Pyrrolidine
substituent:Quaternary ammonium salt
substituent:Tertiary alcohol
substituent:Tetraalkylammonium salt

消除途径

After administration of oral 14C-trospium chloride, the majority of the dose (85.2%) was recovered in feces and a smaller amount (5.8% of the dose) was recovered in urine; 60% of the radioactivity excreted in urine was unchanged trospium. Trospium mainly undergoes elimination via active tubular secretion, as indicated by the mean renal clearance of 29.07 L/hour, which is about 4-fold higher than average glomerular filtration rate. Trospium is metabolized by ester hydrolysis and excreted by the kidneys by a combination of tubular secretion and glomerular filtration.

种类

Acids, Carbocyclic
D000146
Agents producing tachycardia

Alimentary Tract and Metabolism

Alkaloids
D000470
Anticholinergic Agents
D018680
Autonomic Agents
D001337
Aza Compounds
D001372
Azabicyclo Compounds
D053961
Cholinergic Agents
D018678
Cytochrome P-450 CYP2D6 Inhibitors
D065690
Cytochrome P-450 CYP2D6 Inhibitors (weak)

Cytochrome P-450 Enzyme Inhibitors
D065607
Diphenylacetic Acids
D004158
Drugs for Functional Gastrointestinal Disorders

Drugs for Urinary Frequency and Incontinence

Genito Urinary System and Sex Hormones

Hydroxy Acids
D006880
Muscarinic Antagonists
D018727
Neurotransmitter Agents
D018377
Parasympatholytics
D010276
Peripheral Nervous System Agents
D018373
Phenylacetates
D010648
Tropanes
D014326
Urological Agents
D064804
Urologicals

盐类

DBSALT000883Trospium chloride1E6682427E10405-02-4RVCSYOQWLPPAOA-QKYUOBHYSA-M427.97427.1914215

蛋白质结合

50-85%

清除

* Renal cl=29.07 L/hour

同义词

国际品牌

FlotrosRegurinSpasmexSpasmolytSpasmoplexTropez OD

配送量

* 395 ± 140 L

产品

name:Accel-trospium
labeller:Accel Pharma Inc
ndc-id:
ndc-product-code:
dpd-id:02492717
ema-product-code:
ema-ma-number:
started-marketing-on:
ended-marketing-on:
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Jamp Trospium
labeller:Jamp Pharma Corporation
ndc-id:
ndc-product-code:
dpd-id:02506661
ema-product-code:
ema-ma-number:
started-marketing-on:
ended-marketing-on:
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Mar-trospium
labeller:Marcan Pharmaceuticals Inc
ndc-id:
ndc-product-code:
dpd-id:02488353
ema-product-code:
ema-ma-number:
started-marketing-on:2019-06-21
ended-marketing-on:
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Sanctura
labeller:Allergan
ndc-id:
ndc-product-code:0023-3513
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2007-12-01
ended-marketing-on:2015-09-19
dosage-form:Tablet
strength:20 mg/1
route:Oral
fda-application-number:NDA021595
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Sanctura XR
labeller:Esprit Pharmaceuticals
ndc-id:
ndc-product-code:15456-981
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2007-08-01
ended-marketing-on:2008-05-01
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:NDA022103
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Sanctura XR
labeller:Allergan
ndc-id:
ndc-product-code:0023-9350
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2007-12-01
ended-marketing-on:2015-03-04
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:NDA022103
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Sanctura XR
labeller:Physicians Total Care, Inc.
ndc-id:
ndc-product-code:54868-6174
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2010-09-15
ended-marketing-on:2013-06-30
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:NDA022103
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Sanctura XR
labeller:Allergan
ndc-id:
ndc-product-code:
dpd-id:02339706
ema-product-code:
ema-ma-number:
started-marketing-on:2010-01-20
ended-marketing-on:2016-04-13
dosage-form:Capsule, extended release
strength:60 mg
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Trosec
labeller:Sunovion
ndc-id:
ndc-product-code:
dpd-id:02275066
ema-product-code:
ema-ma-number:
started-marketing-on:2006-04-04
ended-marketing-on:
dosage-form:Tablet
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Trospium Chloride
labeller:Amerincan Health Packaging
ndc-id:
ndc-product-code:68084-888
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-12-15
ended-marketing-on:2015-07-09
dosage-form:Tablet
strength:20 mg/1
route:Oral
fda-application-number:ANDA091513
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Biomes Pharmaceuticals
ndc-id:
ndc-product-code:69150-258
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2010-08-13
ended-marketing-on:
dosage-form:Tablet
strength:20 mg/1
route:Oral
fda-application-number:ANDA091575
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Blue Point Laboratories
ndc-id:
ndc-product-code:68001-228
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-03-11
ended-marketing-on:
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:ANDA091289
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Golden State Medical Supply, Inc.
ndc-id:
ndc-product-code:60429-098
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2014-07-18
ended-marketing-on:
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:ANDA091289
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Paddock Laboratories, LLC
ndc-id:
ndc-product-code:0574-0145
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2010-11-17
ended-marketing-on:
dosage-form:Tablet, film coated
strength:20 mg/1
route:Oral
fda-application-number:ANDA091573
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Actavis Pharma, Inc.
ndc-id:
ndc-product-code:0591-3636
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2012-10-12
ended-marketing-on:
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:ANDA091289
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Exelan Pharmaceuticals Inc.
ndc-id:
ndc-product-code:76282-336
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2017-07-11
ended-marketing-on:
dosage-form:Tablet, film coated
strength:20 mg/1
route:Oral
fda-application-number:ANDA091688
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Cipla USA Inc.,
ndc-id:
ndc-product-code:69097-912
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-09-23
ended-marketing-on:
dosage-form:Tablet, film coated
strength:20 mg/1
route:Oral
fda-application-number:ANDA091688
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Glenmark Pharmaceuticals Inc., USA
ndc-id:
ndc-product-code:68462-461
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2010-08-13
ended-marketing-on:
dosage-form:Tablet, film coated
strength:20 mg/1
route:Oral
fda-application-number:ANDA091575
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Apotex Corp.
ndc-id:
ndc-product-code:60505-3454
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2012-10-15
ended-marketing-on:2021-05-31
dosage-form:Tablet
strength:20 mg/1
route:Oral
fda-application-number:ANDA091513
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:AvKARE
ndc-id:
ndc-product-code:42291-846
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-10-06
ended-marketing-on:
dosage-form:Tablet
strength:20 mg/1
route:Oral
fda-application-number:ANDA091513
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Major Pharmaceuticals
ndc-id:
ndc-product-code:0904-7059
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2015-11-16
ended-marketing-on:
dosage-form:Tablet, film coated
strength:20 mg/1
route:Oral
fda-application-number:ANDA204945
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
ndc-id:
ndc-product-code:23155-530
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-08-30
ended-marketing-on:
dosage-form:Tablet, film coated
strength:20 mg/1
route:Oral
fda-application-number:ANDA204945
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Granules Pharmaceuticals Inc.
ndc-id:
ndc-product-code:70010-027
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2020-08-19
ended-marketing-on:
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:ANDA213185
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:Golden State Medical Supply, Inc.
ndc-id:
ndc-product-code:60429-103
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2013-02-08
ended-marketing-on:2016-06-30
dosage-form:Tablet
strength:20 mg/1
route:Oral
fda-application-number:ANDA091513
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride
labeller:BluePoint Laboratories
ndc-id:
ndc-product-code:68001-427
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2020-07-10
ended-marketing-on:
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:ANDA213185
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Trospium Chloride ER
labeller:Paddock Laboratories, LLC
ndc-id:
ndc-product-code:0574-0118
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2013-06-07
ended-marketing-on:
dosage-form:Capsule, extended release
strength:60 mg/1
route:Oral
fda-application-number:ANDA201291
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC

混合物

name:Sanctura XR
ingredients:Trospium
name:Sanctura XR
ingredients:Trospium
name:Sanctura XR
ingredients:Trospium
name:Sanctura
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride ER
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trospium Chloride
ingredients:Trospium
name:Trosec
ingredients:Trospium
name:Sanctura XR
ingredients:Trospium
name:Mar-trospium
ingredients:Trospium
name:Accel-trospium
ingredients:Trospium
name:Jamp Trospium
ingredients:Trospium

包装者

name:Allergan Inc.
url:http://www.allergan.com
name:Catalent Pharma Solutions
url:http://www.catalent.com
name:Endo Pharmaceuticals Inc.
url:http://www.endo.com
name:Esprit Pharma Inc.
url:
name:Madaus GmbH
url:http://www.madaus.de
name:Murfreesboro Pharmaceutical Nursing Supply
url:http://www.unitdosesupply.com
name:Odyssey Pharmaceuticals Inc.
url:
name:Redpharm Drug
url:

生产者

generic:否; url:; name;Allergan inc

价格

Sanctura 20 mg tablet
3.12(单位：USD）
tablet
Sanctura xr 60 mg capsule
5.02(单位：USD）
capsule
Sanctura XR 60 mg 24 Hour Capsule
5.17(单位：USD）
capsule

受影响的生物体

Humans and other mammals

剂量

form:Tablet
route:Oral
strength:20 mg/1
form:Capsule, extended release
route:Oral
strength:60 mg/1
form:Tablet, film coated
route:Oral
strength:15 MG
form:Tablet, film coated
route:Oral
strength:30 MG
form:Tablet, coated
route:Oral
strength:15 mg
form:Tablet, film coated
route:Oral
strength:20 MG
form:Tablet, film coated
route:Oral
strength:45 MG
form:Tablet, sugar coated
route:Oral
strength:20 mg
form:Tablet, coated
route:Oral
strength:10 MG
form:Tablet, coated
route:Oral
strength:
form:Tablet, coated
route:Oral
strength:20 MG
form:Tablet, film coated
route:Oral
strength:5 MG
form:Tablet
route:Oral
strength:
form:Tablet
route:Oral
strength:30 MG
form:Tablet
route:Oral
strength:5 MG
form:Tablet, film coated
route:Oral
strength:20 mg/1
form:Tablet, film coated
route:Oral
strength:
form:Capsule, extended release
route:Oral
strength:60 mg
form:Tablet, coated
route:Oral
strength:30 mg

atc代码

Synthetic anticholinergic agents in combination with analgesics
ANTISPASMODICS IN COMBINATION WITH ANALGESICS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
ALIMENTARY TRACT AND METABOLISM
Drugs for urinary frequency and incontinence
UROLOGICALS
UROLOGICALS
GENITO URINARY SYSTEM AND SEX HORMONES

fda标签

//s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00209.pdf?1265922806

化学品安全技术说明书

专利

number:2537103
country:Canada
approved:2010-01-19
expires:2024-11-04
pediatric-extension:否
number:7759359
country:United States
approved:2010-07-20
expires:2024-11-04
pediatric-extension:否
number:7763635
country:United States
approved:2010-07-27
expires:2024-11-04
pediatric-extension:否
number:7781448
country:United States
approved:2010-08-24
expires:2024-11-04
pediatric-extension:否
number:7781449
country:United States
approved:2010-08-24
expires:2024-11-04
pediatric-extension:否
number:7410978
country:United States
approved:2008-08-12
expires:2025-02-01
pediatric-extension:否

食物相互作用

Take on an empty stomach. Take at least 1 hour before food as the Cmax and AUC of trospium are reduced by 70-80% when taken with a high fat meal.

药物相互作用

DB08897
The risk or severity of adverse effects can be increased when Trospium is combined with Aclidinium.
DB00331
The serum concentration of Trospium can be decreased when it is combined with Metformin.
DB06148
Mianserin may increase the anticholinergic activities of Trospium.
DB08893
The risk or severity of urinary retention can be increased when Trospium is combined with Mirabegron.
DB00761
The risk or severity of gastrointestinal ulceration can be increased when Trospium is combined with Potassium chloride.
DB01278
The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Trospium.
DB09527
The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Trospium.
DB01409
The risk or severity of adverse effects can be increased when Trospium is combined with Tiotropium.
DB00273
The risk or severity of hyperthermia and oligohydrosis can be increased when Trospium is combined with Topiramate.
DB09076
The risk or severity of adverse effects can be increased when Trospium is combined with Umeclidinium.
DB00289
The metabolism of Atomoxetine can be decreased when combined with Trospium.
DB00986
The risk or severity of adverse effects can be increased when Trospium is combined with Glycopyrronium.
DB00083
The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum toxin type A.
DB00040
Trospium may increase the gastrointestinal motility reducing activities of Glucagon.
DB00391
Trospium may increase the anticholinergic activities of Sulpiride.
DB00042
The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum Toxin Type B.
DB09272
The risk or severity of constipation can be increased when Trospium is combined with Eluxadoline.
DB09290
The risk or severity of constipation can be increased when Trospium is combined with Ramosetron.
DB00704
The risk or severity of adverse effects can be increased when Trospium is combined with Naltrexone.
DB01459
The risk or severity of adverse effects can be increased when Trospium is combined with Bezitramide.
DB00295
The risk or severity of adverse effects can be increased when Morphine is combined with Trospium.
DB00318
The risk or severity of adverse effects can be increased when Codeine is combined with Trospium.
DB00327
The risk or severity of adverse effects can be increased when Hydromorphone is combined with Trospium.
DB00333
The risk or severity of adverse effects can be increased when Methadone is combined with Trospium.
DB00497
The risk or severity of adverse effects can be increased when Oxycodone is combined with Trospium.
DB00611
The risk or severity of adverse effects can be increased when Butorphanol is combined with Trospium.
DB00647
The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Trospium.
DB00652
The risk or severity of adverse effects can be increased when Pentazocine is combined with Trospium.
DB00708
The risk or severity of adverse effects can be increased when Sufentanil is combined with Trospium.
DB00802
The risk or severity of adverse effects can be increased when Alfentanil is combined with Trospium.
DB00813
The risk or severity of adverse effects can be increased when Fentanyl is combined with Trospium.
DB00844
The risk or severity of adverse effects can be increased when Nalbuphine is combined with Trospium.
DB00854
The risk or severity of adverse effects can be increased when Levorphanol is combined with Trospium.
DB00899
The risk or severity of adverse effects can be increased when Remifentanil is combined with Trospium.
DB00921
The risk or severity of adverse effects can be increased when Buprenorphine is combined with Trospium.
DB00956
The risk or severity of adverse effects can be increased when Hydrocodone is combined with Trospium.
DB01081
The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Trospium.
DB01192
The risk or severity of adverse effects can be increased when Oxymorphone is combined with Trospium.
DB01209
The risk or severity of adverse effects can be increased when Dezocine is combined with Trospium.
DB01227
The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Trospium.
DB01433
The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Trospium.
DB01450
The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Trospium.
DB01452
The risk or severity of adverse effects can be increased when Diamorphine is combined with Trospium.
DB01466
The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Trospium.
DB01497
The risk or severity of adverse effects can be increased when Etorphine is combined with Trospium.
DB01529
The risk or severity of adverse effects can be increased when Dextromoramide is combined with Trospium.
DB01531
The risk or severity of adverse effects can be increased when Desomorphine is combined with Trospium.
DB01535
The risk or severity of adverse effects can be increased when Carfentanil is combined with Trospium.
DB01551
The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Trospium.
DB01555
The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Trospium.
DB01565
The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Trospium.
DB06204
The risk or severity of adverse effects can be increased when Tapentadol is combined with Trospium.
DB06738
The risk or severity of adverse effects can be increased when Ketobemidone is combined with Trospium.
DB08861
The risk or severity of adverse effects can be increased when DPDPE is combined with Trospium.
DB09174
The risk or severity of adverse effects can be increased when Lofentanil is combined with Trospium.
DB11130
The risk or severity of adverse effects can be increased when Opium is combined with Trospium.
DB11609
The risk or severity of adverse effects can be increased when Normethadone is combined with Trospium.
DB12492
The risk or severity of adverse effects can be increased when Piritramide is combined with Trospium.
DB13160
The risk or severity of adverse effects can be increased when Alphaprodine is combined with Trospium.
DB13454
The risk or severity of adverse effects can be increased when Nicomorphine is combined with Trospium.
DB13478
The risk or severity of adverse effects can be increased when Meptazinol is combined with Trospium.
DB13605
The risk or severity of adverse effects can be increased when Phenoperidine is combined with Trospium.
DB13606
The risk or severity of adverse effects can be increased when Phenazocine is combined with Trospium.
DB13787
The risk or severity of adverse effects can be increased when Tilidine is combined with Trospium.
DB15360
The risk or severity of adverse effects can be increased when Carfentanil, C-11 is combined with Trospium.
DB00454
The risk or severity of adverse effects can be increased when Trospium is combined with Meperidine.
DB15465
The risk or severity of adverse effects can be increased when Trospium is combined with Benzhydrocodone.
DB00898
The risk or severity of drowsiness and CNS depression can be increased when Ethanol is combined with Trospium.
DB00219
The risk or severity of adverse effects can be increased when Trospium is combined with Oxyphenonium.
DB00245
The risk or severity of adverse effects can be increased when Trospium is combined with Benzatropine.
DB00280
The risk or severity of adverse effects can be increased when Trospium is combined with Disopyramide.
DB00340
The risk or severity of adverse effects can be increased when Trospium is combined with Metixene.
DB00354
The risk or severity of adverse effects can be increased when Trospium is combined with Buclizine.
DB00376
The risk or severity of adverse effects can be increased when Trospium is combined with Trihexyphenidyl.
DB00383
The risk or severity of adverse effects can be increased when Trospium is combined with Oxyphencyclimine.
DB00387
The risk or severity of adverse effects can be increased when Trospium is combined with Procyclidine.
DB00424
The risk or severity of adverse effects can be increased when Trospium is combined with Hyoscyamine.
DB00462
The risk or severity of adverse effects can be increased when Trospium is combined with Methscopolamine bromide.
DB00496
The risk or severity of adverse effects can be increased when Trospium is combined with Darifenacin.
DB00505
The risk or severity of adverse effects can be increased when Trospium is combined with Tridihexethyl.
DB00517
The risk or severity of adverse effects can be increased when Trospium is combined with Anisotropine methylbromide.
DB00572
The risk or severity of adverse effects can be increased when Trospium is combined with Atropine.
DB00622
The risk or severity of adverse effects can be increased when Trospium is combined with Nicardipine.
DB00657
The risk or severity of adverse effects can be increased when Trospium is combined with Mecamylamine.
DB00670
The risk or severity of adverse effects can be increased when Trospium is combined with Pirenzepine.
DB00725
The risk or severity of adverse effects can be increased when Trospium is combined with Homatropine methylbromide.
DB00767
The risk or severity of adverse effects can be increased when Trospium is combined with Benzquinamide.
DB00782
The risk or severity of adverse effects can be increased when Trospium is combined with Propantheline.
DB00804
The risk or severity of adverse effects can be increased when Trospium is combined with Dicyclomine.
DB00809
The risk or severity of adverse effects can be increased when Trospium is combined with Tropicamide.
DB00907
The risk or severity of adverse effects can be increased when Trospium is combined with Cocaine.
DB00908
The risk or severity of adverse effects can be increased when Trospium is combined with Quinidine.
DB00915
The risk or severity of adverse effects can be increased when Trospium is combined with Amantadine.
DB00940
The risk or severity of adverse effects can be increased when Trospium is combined with Methantheline.
DB00942
The risk or severity of adverse effects can be increased when Trospium is combined with Cycrimine.
DB00979
The risk or severity of adverse effects can be increased when Trospium is combined with Cyclopentolate.
DB01036
The risk or severity of adverse effects can be increased when Trospium is combined with Tolterodine.
DB01062
The risk or severity of adverse effects can be increased when Trospium is combined with Oxybutynin.
DB01090
The risk or severity of adverse effects can be increased when Trospium is combined with Pentolinium.
DB01116
The risk or severity of adverse effects can be increased when Trospium is combined with Trimethaphan.
DB01148
The risk or severity of adverse effects can be increased when Trospium is combined with Flavoxate.
DB01161
The risk or severity of adverse effects can be increased when Trospium is combined with Chloroprocaine.
DB01231
The risk or severity of adverse effects can be increased when Trospium is combined with Diphenidol.
DB01288
The risk or severity of adverse effects can be increased when Trospium is combined with Fenoterol.
DB01496
The risk or severity of adverse effects can be increased when Trospium is combined with Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione.
DB01591
The risk or severity of adverse effects can be increased when Trospium is combined with Solifenacin.
DB01625
The risk or severity of adverse effects can be increased when Trospium is combined with Isopropamide.
DB04843
The risk or severity of adverse effects can be increased when Trospium is combined with Mepenzolate.
DB06702
The risk or severity of adverse effects can be increased when Trospium is combined with Fesoterodine.
DB06787
The risk or severity of adverse effects can be increased when Trospium is combined with Hexocyclium.
DB08801
The risk or severity of adverse effects can be increased when Trospium is combined with Dimetindene.
DB08838
The risk or severity of adverse effects can be increased when Trospium is combined with Agmatine.
DB08997
The risk or severity of adverse effects can be increased when Trospium is combined with Dexetimide.
DB09007
The risk or severity of adverse effects can be increased when Trospium is combined with Chlorphenoxamine.
DB09089
The risk or severity of adverse effects can be increased when Trospium is combined with Trimebutine.
DB09262
The risk or severity of adverse effects can be increased when Trospium is combined with Imidafenacin.
DB09300
The risk or severity of adverse effects can be increased when Trospium is combined with Butylscopolamine.
DB11181
The risk or severity of adverse effects can be increased when Trospium is combined with Homatropine.
DB11235
The risk or severity of adverse effects can be increased when Trospium is combined with Thonzylamine.
DB11315
The risk or severity of adverse effects can be increased when Trospium is combined with Methscopolamine.
DB12086
The risk or severity of adverse effects can be increased when Trospium is combined with Oxitropium.
DB12278
The risk or severity of adverse effects can be increased when Trospium is combined with Propiverine.
DB12526
The risk or severity of adverse effects can be increased when Trospium is combined with Batefenterol.
DB12554
The risk or severity of adverse effects can be increased when Trospium is combined with Mebeverine.
DB13252
The risk or severity of adverse effects can be increased when Trospium is combined with Tropatepine.
DB13254
The risk or severity of adverse effects can be increased when Trospium is combined with Prifinium.
DB13351
The risk or severity of adverse effects can be increased when Trospium is combined with Piperidolate.
DB13369
The risk or severity of adverse effects can be increased when Trospium is combined with Benzilone.
DB13380
The risk or severity of adverse effects can be increased when Trospium is combined with Difemerine.
DB13413
The risk or severity of adverse effects can be increased when Trospium is combined with Phenglutarimide.
DB13448
The risk or severity of adverse effects can be increased when Trospium is combined with Mazaticol.
DB13468
The risk or severity of adverse effects can be increased when Trospium is combined with Etybenzatropine.
DB13500
The risk or severity of adverse effects can be increased when Trospium is combined with Otilonium.
DB13507
The risk or severity of adverse effects can be increased when Trospium is combined with Poldine.
DB13542
The risk or severity of adverse effects can be increased when Trospium is combined with Bevonium.
DB13581
The risk or severity of adverse effects can be increased when Trospium is combined with Rociverine.
DB13619
The risk or severity of adverse effects can be increased when Trospium is combined with Bornaprine.
DB13636
The risk or severity of adverse effects can be increased when Trospium is combined with Etanautine.
DB13666
The risk or severity of adverse effects can be increased when Trospium is combined with Tiemonium iodide.
DB13678
The risk or severity of adverse effects can be increased when Trospium is combined with Dihexyverine.
DB13695
The risk or severity of adverse effects can be increased when Trospium is combined with Penthienate.
DB13720
The risk or severity of adverse effects can be increased when Trospium is combined with Diphemanil.
DB13738
The risk or severity of adverse effects can be increased when Trospium is combined with Camylofin.
DB13759
The risk or severity of adverse effects can be increased when Trospium is combined with Fenpiverinium.
DB13769
The risk or severity of adverse effects can be increased when Trospium is combined with Emetonium iodide.
DB13844
The risk or severity of adverse effects can be increased when Trospium is combined with Pipenzolate.
DB13850
The risk or severity of adverse effects can be increased when Trospium is combined with Timepidium.
DB09271
The risk or severity of adverse effects can be increased when Trospium is combined with Cimetropium.
DB00232
The serum concentration of Methyclothiazide can be increased when it is combined with Trospium.
DB00310
The serum concentration of Chlorthalidone can be increased when it is combined with Trospium.
DB00436
The serum concentration of Bendroflumethiazide can be increased when it is combined with Trospium.
DB00524
The serum concentration of Metolazone can be increased when it is combined with Trospium.
DB00562
The serum concentration of Benzthiazide can be increased when it is combined with Trospium.
DB00774
The serum concentration of Hydroflumethiazide can be increased when it is combined with Trospium.
DB00808
The serum concentration of Indapamide can be increased when it is combined with Trospium.
DB00880
The serum concentration of Chlorothiazide can be increased when it is combined with Trospium.
DB00999
The serum concentration of Hydrochlorothiazide can be increased when it is combined with Trospium.
DB01021
The serum concentration of Trichlormethiazide can be increased when it is combined with Trospium.
DB01324
The serum concentration of Polythiazide can be increased when it is combined with Trospium.
DB01325
The serum concentration of Quinethazone can be increased when it is combined with Trospium.
DB13532
The serum concentration of Cyclopenthiazide can be increased when it is combined with Trospium.
DB13989
The serum concentration of Epitizide can be increased when it is combined with Trospium.
DB00332
The risk or severity of adverse effects can be increased when Trospium is combined with Ipratropium.
DB00470
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Dronabinol.
DB00486
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Nabilone.
DB05077
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with SLV319.
DB06155
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Rimonabant.
DB06624
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Taranabant.
DB09061
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Cannabidiol.
DB11903
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with GW842166.
DB12193
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Ajulemic acid.
DB12649
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Ibipinabant.
DB13070
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Surinabant.
DB13950
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with WIN 55212-2.
DB14011
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Nabiximols.
DB14043
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Palmidrol.
DB14737
The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Cannabinol.
DB00082
The therapeutic efficacy of Trospium can be decreased when used in combination with Pegvisomant.
DB00358
The therapeutic efficacy of Trospium can be decreased when used in combination with Mefloquine.
DB00382
The therapeutic efficacy of Trospium can be decreased when used in combination with Tacrine.
DB00392
The therapeutic efficacy of Trospium can be decreased when used in combination with Profenamine.
DB00515
The therapeutic efficacy of Trospium can be decreased when used in combination with Cisplatin.
DB00527
The therapeutic efficacy of Trospium can be decreased when used in combination with Cinchocaine.
DB00545
The therapeutic efficacy of Trospium can be decreased when used in combination with Pyridostigmine.
DB00585
The therapeutic efficacy of Trospium can be decreased when used in combination with Nizatidine.
DB00674
The therapeutic efficacy of Trospium can be decreased when used in combination with Galantamine.
DB00677
The therapeutic efficacy of Trospium can be decreased when used in combination with Isoflurophate.
DB00711
The therapeutic efficacy of Trospium can be decreased when used in combination with Diethylcarbamazine.
DB00871
The therapeutic efficacy of Trospium can be decreased when used in combination with Terbutaline.
DB00888
The therapeutic efficacy of Trospium can be decreased when used in combination with Mechlorethamine.
DB00944
The therapeutic efficacy of Trospium can be decreased when used in combination with Demecarium.
DB00981
The therapeutic efficacy of Trospium can be decreased when used in combination with Physostigmine.
DB00989
The therapeutic efficacy of Trospium can be decreased when used in combination with Rivastigmine.
DB01010
The therapeutic efficacy of Trospium can be decreased when used in combination with Edrophonium.
DB01043
The therapeutic efficacy of Trospium can be decreased when used in combination with Memantine.
DB01122
The therapeutic efficacy of Trospium can be decreased when used in combination with Ambenonium.
DB01381
The therapeutic efficacy of Trospium can be decreased when used in combination with Ginkgo biloba.
DB01400
The therapeutic efficacy of Trospium can be decreased when used in combination with Neostigmine.
DB01408
The therapeutic efficacy of Trospium can be decreased when used in combination with Bambuterol.
DB02365
The therapeutic efficacy of Trospium can be decreased when used in combination with 1,10-Phenanthroline.
DB04572
The therapeutic efficacy of Trospium can be decreased when used in combination with Thiotepa.
DB04864
The therapeutic efficacy of Trospium can be decreased when used in combination with Huperzine A.
DB04892
The therapeutic efficacy of Trospium can be decreased when used in combination with Phenserine.
DB05386
The therapeutic efficacy of Trospium can be decreased when used in combination with Regramostim.
DB06692
The therapeutic efficacy of Trospium can be decreased when used in combination with Aprotinin.
DB06756
The therapeutic efficacy of Trospium can be decreased when used in combination with Glycine betaine.
DB06774
The therapeutic efficacy of Trospium can be decreased when used in combination with Capsaicin.
DB11390
The therapeutic efficacy of Trospium can be decreased when used in combination with Coumaphos.
DB11397
The therapeutic efficacy of Trospium can be decreased when used in combination with Dichlorvos.
DB11412
The therapeutic efficacy of Trospium can be decreased when used in combination with Fenthion.
DB11473
The therapeutic efficacy of Trospium can be decreased when used in combination with Metrifonate.
DB12482
The therapeutic efficacy of Trospium can be decreased when used in combination with Acotiamide.
DB13058
The therapeutic efficacy of Trospium can be decreased when used in combination with Methanesulfonyl Fluoride.
DB13495
The therapeutic efficacy of Trospium can be decreased when used in combination with Paraoxon.
DB13503
The therapeutic efficacy of Trospium can be decreased when used in combination with Tyrothricin.
DB13668
The therapeutic efficacy of Trospium can be decreased when used in combination with Ipidacrine.
DB13694
The therapeutic efficacy of Trospium can be decreased when used in combination with Distigmine.
DB14031
The therapeutic efficacy of Trospium can be decreased when used in combination with Tretamine.
DB15317
The therapeutic efficacy of Trospium can be decreased when used in combination with Posiphen.
DB02845
The therapeutic efficacy of Trospium can be decreased when used in combination with Methylphosphinic Acid.
DB00581
The therapeutic efficacy of Lactulose can be decreased when used in combination with Trospium.
DB01046
The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Trospium.
DB01079
The therapeutic efficacy of Tegaserod can be decreased when used in combination with Trospium.
DB01377
The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Trospium.
DB01378
The therapeutic efficacy of Magnesium cation can be decreased when used in combination with Trospium.
DB01593
The therapeutic efficacy of Zinc can be decreased when used in combination with Trospium.
DB01638
The therapeutic efficacy of Sorbitol can be decreased when used in combination with Trospium.
DB04816
The therapeutic efficacy of Dantron can be decreased when used in combination with Trospium.
DB04823
The therapeutic efficacy of Oxyphenisatin can be decreased when used in combination with Trospium.
DB04824
The therapeutic efficacy of Phenolphthalein can be decreased when used in combination with Trospium.
DB06480
The therapeutic efficacy of Prucalopride can be decreased when used in combination with Trospium.
DB07715
The therapeutic efficacy of Emodin can be decreased when used in combination with Trospium.
DB08890
The therapeutic efficacy of Linaclotide can be decreased when used in combination with Trospium.
DB09020
The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Trospium.
DB09104
The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Trospium.
DB09219
The therapeutic efficacy of Bisoxatin can be decreased when used in combination with Trospium.
DB09268
The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Trospium.
DB09281
The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Trospium.
DB09287
The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Trospium.
DB09311
The therapeutic efficacy of Polycarbophil can be decreased when used in combination with Trospium.
DB09413
The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Trospium.
DB09414
The therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Trospium.
DB09449
The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Trospium.
DB09462
The therapeutic efficacy of Glycerin can be decreased when used in combination with Trospium.
DB09472
The therapeutic efficacy of Sodium sulfate can be decreased when used in combination with Trospium.
DB09481
The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Trospium.
DB09484
The therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Trospium.
DB11057
The therapeutic efficacy of Mineral oil can be decreased when used in combination with Trospium.
DB11059
The therapeutic efficacy of Carboxymethylcellulose can be decreased when used in combination with Trospium.
DB11089
The therapeutic efficacy of Docusate can be decreased when used in combination with Trospium.
DB11097
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Trospium.
DB11110
The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Trospium.
DB11113
The therapeutic efficacy of Castor oil can be decreased when used in combination with Trospium.
DB11189
The therapeutic efficacy of Magnesium glycinate can be decreased when used in combination with Trospium.
DB11228
The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Trospium.
DB11365
The therapeutic efficacy of Sennosides can be decreased when used in combination with Trospium.
DB12942
The therapeutic efficacy of Lactitol can be decreased when used in combination with Trospium.
DB13170
The therapeutic efficacy of Plecanatide can be decreased when used in combination with Trospium.
DB13486
The therapeutic efficacy of Magnesium peroxide can be decreased when used in combination with Trospium.
DB13526
The therapeutic efficacy of Pentaerithrityl can be decreased when used in combination with Trospium.
DB13707
The therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Trospium.
DB14232
The therapeutic efficacy of Deacetylbisacodyl can be decreased when used in combination with Trospium.
DB14482
The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Trospium.
DB14499
The therapeutic efficacy of Potassium sulfate can be decreased when used in combination with Trospium.
DB14502
The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Trospium.
DB14503
The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Trospium.
DB14504
The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Trospium.
DB14513
The therapeutic efficacy of Magnesium can be decreased when used in combination with Trospium.
DB14585
The therapeutic efficacy of Plantago ovata seed can be decreased when used in combination with Trospium.
DB14627
The therapeutic efficacy of Oxyphenisatin acetate can be decreased when used in combination with Trospium.
DB14684
The therapeutic efficacy of Calcium polycarbophil can be decreased when used in combination with Trospium.
DB14963
The therapeutic efficacy of Konjac mannan can be decreased when used in combination with Trospium.
DB15477
The therapeutic efficacy of Alloin can be decreased when used in combination with Trospium.
DB15478
The therapeutic efficacy of Frangula purshiana bark can be decreased when used in combination with Trospium.
DB11622
The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Trospium.
DB14516
The therapeutic efficacy of Sodium cation can be decreased when used in combination with Trospium.
DB14546
The therapeutic efficacy of Sulfate ion can be decreased when used in combination with Trospium.
DB00477
Chlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00483
Gallamine triethiodide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00508
Triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00721
Procaine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00805
Minaprine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00941
Hexafluronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01199
Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01221
Ketamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01245
Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01337
Pancuronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01338
Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00150
Tryptophan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00176
Fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00181
Baclofen may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00182
Amphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00186
Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00189
Ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00202
Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00206
Reserpine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00215
Citalopram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00216
Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00228
Enflurane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00230
Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00231
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00234
Reboxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00237
Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00241
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00246
Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00247
Methysergide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00248
Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00252
Phenytoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00268
Ropinirole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00283
Clemastine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00285
Venlafaxine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00292
Etomidate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00306
Talbutal may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00312
Pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00313
Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00315
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00320
Dihydroergotamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00323
Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00334
Olanzapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00341
Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00347
Trimethadione may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00349
Clobazam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00356
Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00363
Clozapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00366
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00370
Mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00371
Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00372
Thiethylperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00377
Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00395
Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00402
Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00404
Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00405
Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00408
Loxapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00409
Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00416
Metocurine iodide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00418
Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00420
Promazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00423
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00425
Zolpidem may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00427
Triprolidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00433
Prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00434
Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00450
Droperidol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00463
Metharbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00468
Quinine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00472
Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00474
Methohexital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00475
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00476
Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00494
Entacapone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00514
Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00546
Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00555
Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00557
Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00564
Carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00565
Cisatracurium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00574
Fenfluramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00579
Mazindol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00588
Fluticasone propionate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00589
Lisuride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00593
Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00599
Thiopental may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00601
Linezolid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00604
Cisapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00614
Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00617
Paramethadione may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00623
Fluphenazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00625
Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00628
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00633
Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00645
Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00656
Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00660
Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00662
Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00669
Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00679
Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00680
Moricizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00683
Midazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00690
Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00696
Ergotamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00697
Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00714
Apomorphine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00715
Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00728
Rocuronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00732
Atracurium besylate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00734
Risperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00737
Meclizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00740
Riluzole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00747
Scopolamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00748
Carbinoxamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00752
Tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00753
Isoflurane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00754
Ethotoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00757
Dolasetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00771
Clidinium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00776
Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00777
Propiomazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00780
Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00794
Primidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00801
Halazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00818
Propofol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00819
Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00829
Diazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00831
Trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00832
Phensuximide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00835
Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00837
Progabide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00842
Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00849
Methylphenobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00850
Perphenazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00865
Benzphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00866
Alprenolol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00875
Flupentixol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00889
Granisetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00897
Triazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00904
Ondansetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00906
Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00909
Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00918
Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00933
Mesoridazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00934
Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00937
Diethylpropion may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00949
Felbamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00952
Naratriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00953
Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00960
Pindolol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00962
Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00969
Alosetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00972
Azelastine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00980
Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00985
Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00996
Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00998
Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01018
Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01028
Methoxyflurane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01037
Selegiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01041
Thalidomide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01049
Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01063
Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01065
Melatonin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01068
Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01069
Promethazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01075
Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01080
Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01104
Sertraline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01105
Sibutramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01106
Levocabastine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01107
Methyprylon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01114
Chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01121
Phenacemide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01135
Doxacurium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01149
Nefazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01154
Thiamylal may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01156
Bupropion may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01159
Halothane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01168
Procarbazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01171
Moclobemide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01173
Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01174
Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01175
Escitalopram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01176
Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01178
Chlormezanone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01186
Pergolide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01189
Desflurane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01198
Zopiclone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01200
Bromocriptine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01202
Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01215
Estazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01219
Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01224
Quetiapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01226
Mivacurium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01236
Sevoflurane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01239
Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01246
Alimemazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01247
Isocarboxazid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01253
Ergometrine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01267
Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01320
Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01323
St. John's Wort may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01336
Metocurine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01339
Vecuronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01351
Amobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01352
Aprobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01353
Butobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01354
Heptabarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01355
Hexobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01356
Lithium cation may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01359
Penbutolol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01367
Rasagiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01392
Yohimbine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01403
Methotrimeprazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01437
Glutethimide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01440
gamma-Hydroxybutyric acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01442
MMDA may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01445
Bufotenine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01454
Midomafetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01463
Fencamfamin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01472
4-Methoxyamphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01483
Barbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01484
4-Bromo-2,5-dimethoxyamphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01488
Dimethyltryptamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01489
Camazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01495
Dichloralphenazone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01501
Difenoxin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01509
Tenamfetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01511
Delorazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01534
Chlorhexadol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01544
Flunitrazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01545
Ethyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01547
Drotebanol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01553
Cloxazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01558
Bromazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01559
Clotiazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01560
Cathinone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01563
Chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01567
Fludiazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01577
Metamfetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01580
Oxprenolol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01587
Ketazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01588
Prazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01589
Quazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01594
Cinolazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01595
Nitrazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01608
Periciazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01614
Acepromazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01615
Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01616
Alverine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01618
Molindone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01621
Pipotiazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01622
Thioproperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01623
Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01624
Zuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01626
Pargyline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01954
Rolipram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB02207
7-Nitroindazole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB02234
S-Ethylisothiourea may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB02852
Domoic Acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB02959
Oxitriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB03575
Phencyclidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04017
Clorgiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04165
Valpromide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04325
Phenethylamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04599
Aniracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04818
Iproniazid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04819
Methapyrilene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04820
Nialamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04821
Nomifensine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04827
Urethane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04829
Lysergic acid diethylamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04832
Zimelidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04833
Methaqualone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04834
Rapacuronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04836
Amineptine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04841
Flunarizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04842
Fluspirilene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04871
Lorcaserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04872
Osanetant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04884
Dapoxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04885
Cilansetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04888
Bifeprunox may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04896
Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04903
Pagoclone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04908
Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04917
Renzapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04946
Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04948
Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB04953
Ezogabine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05227
APD791 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05232
Tetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05246
Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05271
Rotigotine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05316
Pimavanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05541
Brivaracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05542
Naronapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05562
Naluzotan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05607
PRX-08066 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05687
BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB05710
Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06016
Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06077
Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06109
YKP-1358 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06144
Sertindole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06153
Pizotifen may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06201
Rufinamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06216
Asenapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06218
Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06264
Tolperisone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06282
Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06283
Ziconotide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06288
Amisulpride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06446
Dotarizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06458
Remacemide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06470
Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06512
Deramciclane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06527
Tramiprosate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06529
Ocinaplon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06554
Gaboxadol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06579
Adipiplon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06582
Dextofisopam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06594
Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06654
Safinamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06660
Saredutant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06678
Esmirtazapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06684
Vilazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06690
Nitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06691
Mepyramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06700
Desvenlafaxine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06701
Dexmethylphenidate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06716
Fospropofol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06731
Seproxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06753
Triclofos may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06770
Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB06797
Mebutamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08059
Wortmannin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08329
Sulthiame may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08550
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08810
Cinitapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08811
Tofisopam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08815
Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08839
Serotonin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08872
Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08883
Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08892
Arbaclofen Placarbil may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08910
Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08918
Levomilnacipran may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08922
Perospirone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08927
Amperozide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08953
Indalpine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08954
Ifenprodil may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08960
Hexamethonium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08986
Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08992
Eperisone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB08996
Dimetacrine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09000
Cyamemazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09001
Barbexaclone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09011
Beclamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09014
Captodiame may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09016
Butriptyline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09017
Brotizolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09021
Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09023
Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09034
Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09068
Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09071
Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09072
Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09117
Paraldehyde may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09118
Stiripentol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09119
Eslicarbazepine acetate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09128
Brexpiprazole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09166
Etizolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09184
Edivoxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09185
Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09186
Nisoxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09187
Lortalamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09190
Talopram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09194
Etoperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09223
Blonanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09224
Melperone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09225
Zotepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09226
Brilaroxazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09241
Methylene blue may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09243
Hydracarbazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09244
Pirlindole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09245
Toloxatone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09246
Benmoxin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09247
Iproclozide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09248
Mebanazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09249
Octamoxin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09250
Pheniprazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09251
Phenoxypropazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09252
Pivhydrazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09253
Safrazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09254
Caroxazone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09286
Pipamperone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09289
Tianeptine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB09307
Oxaprotiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11156
Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11371
Alfaxalone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11376
Azaperone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11400
Doramectin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11428
Medetomidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11477
Xylazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11540
Propiopromazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11543
Romifidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11549
Tiletamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11552
Tricaine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11555
Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11556
Detomidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11582
Thiocolchicoside may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11664
Psilocybin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11675
Mosapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11686
Iferanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11699
Tropisetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11732
Lasmiditan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11755
Tetrahydrocannabivarin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11823
Esketamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11859
Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11868
Etiracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11889
Lanicemine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11957
Idalopirdine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12071
Vabicaserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12093
Tetrahydropalmatine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12105
Imagabalin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12110
m-Chlorophenylpiperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12111
MK-212 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12131
Vinpocetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12163
Sarpogrelate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12177
Eplivanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12184
Gepirone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12229
Cerlapirdine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12273
Ecopipam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12308
Eltanolone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12327
Salvinorin A may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12338
Carisbamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12361
Piclozotan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12395
Esreboxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12401
Bromperidol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12427
Orvepitant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12465
Ketanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12518
Raclopride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12537
Benzodiazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12576
AZD-3043 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12590
Indiplon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12661
Urapidil may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12693
Ritanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12710
Perazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12725
TD-8954 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12833
Tandospirone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12867
Benperidol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12883
Eltoprazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12951
Pivagabine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12958
Prothipendyl may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12989
Neosaxitoxin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13014
Hypericin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13025
Tiapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13082
Nefiracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13099
Valnoctamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13114
Amitriptylinoxide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13213
Butaperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13219
Medifoxamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13221
Apronalide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13225
Dibenzepin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13233
Alaproclate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13234
Propanidid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13246
Quinupramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13253
Proxibarbal may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13256
Clothiapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13273
Sultopride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13295
Atracurium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13303
Febarbamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13323
Trichloroethylene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13324
Tetrazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13331
Pyrithyldione may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13335
Pinazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13352
Deanol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13354
Phenprobamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13357
Styramate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13362
Pheneturide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13370
Bromisoval may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13377
Vinbarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13382
Chlorproethazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13384
Melitracen may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13396
Neocitrullamon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13402
Acetylglycinamide chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13403
Oxypertine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13411
Lofepramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13414
Fenyramidol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13420
Thiazinam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13437
Medazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13455
Phenibut may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13457
Oxaflozane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13496
Iprindole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13505
Emepronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13520
Metergoline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13522
Mebicar may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13523
Veralipride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13534
Gedocarnil may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13541
Iprazochrome may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13550
Bifemelane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13552
Trifluperidol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13554
Moperone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13557
Thiopropazate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13572
Emylcamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13577
Allobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13584
Gallamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13588
Naftidrofuryl may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13598
Diethyl ether may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13601
Oxiracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13623
Fabomotizole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13642
Pridinol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13643
Loprazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13648
Alcuronium may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13662
Hexapropymate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13665
Fluanisone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13676
Mosapramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13687
Niaprazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13690
Vinyl ether may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13733
Methylpentynol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13737
Cyclobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13745
Fazadinium bromide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13754
Mephenoxalone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13770
Vinylbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13782
Imipramine oxide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13784
Dixyrazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13791
Penfluridol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13799
Ethadione may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13805
Reposal may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13817
Carbromal may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13837
Doxefazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13841
Clopenthixol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13872
Lormetazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13875
Harmaline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13876
Brofaromine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13940
2,5-Dimethoxy-4-ethylthioamphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13948
N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13984
Cyclopropane may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB13993
MRK-409 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14010
5-methoxy-N,N-dimethyltryptamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14028
Nordazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14050
Cannabidivarin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14509
Lithium carbonate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14575
Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14651
Perphenazine enanthate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14672
Oxazepam acetate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14715
Cinazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14718
Pyrazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB14719
Bentazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB15203
JNJ-26489112 may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00967
Trospium may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
DB00653
Trospium may increase the central nervous system depressant (CNS depressant) activities of Magnesium sulfate.
DB00924
Cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB11951
Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB01142
Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00344
Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00532
Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12930
Opipramol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB12404
Remimazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00751
Trospium may increase the central nervous system depressant (CNS depressant) activities of Epinastine.
DB09532
The therapeutic efficacy of Secretin human can be decreased when used in combination with Trospium.
DB01238
The metabolism of Aripiprazole can be decreased when combined with Trospium.
DB14185
The metabolism of Aripiprazole lauroxil can be decreased when combined with Trospium.
DB00184
The metabolism of Nicotine can be decreased when combined with Trospium.
DB00185
The metabolism of Cevimeline can be decreased when combined with Trospium.
DB00187
The metabolism of Esmolol can be decreased when combined with Trospium.
DB00188
The metabolism of Bortezomib can be decreased when combined with Trospium.
DB00195
The metabolism of Betaxolol can be decreased when combined with Trospium.
DB00203
The metabolism of Sildenafil can be decreased when combined with Trospium.
DB00208
The metabolism of Ticlopidine can be decreased when combined with Trospium.
DB00243
The metabolism of Ranolazine can be decreased when combined with Trospium.
DB00264
The metabolism of Metoprolol can be decreased when combined with Trospium.
DB00281
The metabolism of Lidocaine can be decreased when combined with Trospium.
DB00297
The metabolism of Bupivacaine can be decreased when combined with Trospium.
DB00316
The metabolism of Acetaminophen can be decreased when combined with Trospium.
DB00317
The metabolism of Gefitinib can be decreased when combined with Trospium.
DB00335
The metabolism of Atenolol can be decreased when combined with Trospium.
DB00342
The metabolism of Terfenadine can be decreased when combined with Trospium.
DB00343
The metabolism of Diltiazem can be decreased when combined with Trospium.
DB00379
The metabolism of Mexiletine can be decreased when combined with Trospium.
DB00396
The metabolism of Progesterone can be decreased when combined with Trospium.
DB00482
The metabolism of Celecoxib can be decreased when combined with Trospium.
DB00490
The metabolism of Buspirone can be decreased when combined with Trospium.
DB00503
The metabolism of Ritonavir can be decreased when combined with Trospium.
DB00568
The metabolism of Cinnarizine can be decreased when combined with Trospium.
DB00571
The metabolism of Propranolol can be decreased when combined with Trospium.
DB00590
The metabolism of Doxazosin can be decreased when combined with Trospium.
DB00592
The metabolism of Piperazine can be decreased when combined with Trospium.
DB00608
The metabolism of Chloroquine can be decreased when combined with Trospium.
DB00619
The metabolism of Imatinib can be decreased when combined with Trospium.
DB00641
The metabolism of Simvastatin can be decreased when combined with Trospium.
DB00699
The metabolism of Nicergoline can be decreased when combined with Trospium.
DB00701
The metabolism of Amprenavir can be decreased when combined with Trospium.
DB00705
The metabolism of Delavirdine can be decreased when combined with Trospium.
DB00706
The metabolism of Tamsulosin can be decreased when combined with Trospium.
DB00731
The metabolism of Nateglinide can be decreased when combined with Trospium.
DB00738
The metabolism of Pentamidine can be decreased when combined with Trospium.
DB00836
The metabolism of Loperamide can be decreased when combined with Trospium.
DB00914
The metabolism of Phenformin can be decreased when combined with Trospium.
DB00932
The metabolism of Tipranavir can be decreased when combined with Trospium.
DB00983
The metabolism of Formoterol can be decreased when combined with Trospium.
DB01071
The metabolism of Mequitazine can be decreased when combined with Trospium.
DB01074
The metabolism of Perhexiline can be decreased when combined with Trospium.
DB01095
The metabolism of Fluvastatin can be decreased when combined with Trospium.
DB01115
The metabolism of Nifedipine can be decreased when combined with Trospium.
DB01136
The metabolism of Carvedilol can be decreased when combined with Trospium.
DB01166
The metabolism of Cilostazol can be decreased when combined with Trospium.
DB01177
The metabolism of Idarubicin can be decreased when combined with Trospium.
DB01182
The metabolism of Propafenone can be decreased when combined with Trospium.
DB01191
The metabolism of Dexfenfluramine can be decreased when combined with Trospium.
DB01193
The metabolism of Acebutolol can be decreased when combined with Trospium.
DB01203
The metabolism of Nadolol can be decreased when combined with Trospium.
DB01228
The metabolism of Encainide can be decreased when combined with Trospium.
DB01244
The metabolism of Bepridil can be decreased when combined with Trospium.
DB01274
The metabolism of Arformoterol can be decreased when combined with Trospium.
DB01295
The metabolism of Bevantolol can be decreased when combined with Trospium.
DB01297
The metabolism of Practolol can be decreased when combined with Trospium.
DB01424
The metabolism of Aminophenazone can be decreased when combined with Trospium.
DB01429
The metabolism of Aprindine can be decreased when combined with Trospium.
DB01435
The metabolism of Antipyrine can be decreased when combined with Trospium.
DB02703
The metabolism of Fusidic acid can be decreased when combined with Trospium.
DB03783
The metabolism of Phenacetin can be decreased when combined with Trospium.
DB04840
The metabolism of Debrisoquine can be decreased when combined with Trospium.
DB04844
The metabolism of Tetrabenazine can be decreased when combined with Trospium.
DB04846
The metabolism of Celiprolol can be decreased when combined with Trospium.
DB04861
The metabolism of Nebivolol can be decreased when combined with Trospium.
DB04905
The metabolism of Tesmilifene can be decreased when combined with Trospium.
DB04920
The metabolism of Clevidipine can be decreased when combined with Trospium.
DB06203
The metabolism of Alogliptin can be decreased when combined with Trospium.
DB06217
The metabolism of Vernakalant can be decreased when combined with Trospium.
DB06292
The metabolism of Dapagliflozin can be decreased when combined with Trospium.
DB06589
The metabolism of Pazopanib can be decreased when combined with Trospium.
DB06608
The metabolism of Tafenoquine can be decreased when combined with Trospium.
DB06726
The metabolism of Bufuralol can be decreased when combined with Trospium.
DB06727
The metabolism of Sparteine can be decreased when combined with Trospium.
DB06735
The metabolism of Enclomiphene can be decreased when combined with Trospium.
DB08807
The metabolism of Bopindolol can be decreased when combined with Trospium.
DB08808
The metabolism of Bupranolol can be decreased when combined with Trospium.
DB08952
The metabolism of Indenolol can be decreased when combined with Trospium.
DB09039
The metabolism of Eliglustat can be decreased when combined with Trospium.
DB09048
The metabolism of Netupitant can be decreased when combined with Trospium.
DB09053
The metabolism of Ibrutinib can be decreased when combined with Trospium.
DB09183
The metabolism of Dasabuvir can be decreased when combined with Trospium.
DB09195
The metabolism of Lorpiprazole can be decreased when combined with Trospium.
DB09204
The metabolism of Arotinolol can be decreased when combined with Trospium.
DB09288
The metabolism of Propacetamol can be decreased when combined with Trospium.
DB09351
The metabolism of Levobetaxolol can be decreased when combined with Trospium.
DB09555
The metabolism of Dexchlorpheniramine maleate can be decreased when combined with Trospium.
DB11586
The metabolism of Asunaprevir can be decreased when combined with Trospium.
DB11614
The metabolism of Rupatadine can be decreased when combined with Trospium.
DB11770
The metabolism of Talinolol can be decreased when combined with Trospium.
DB11785
The metabolism of Anisodamine can be decreased when combined with Trospium.
DB11855
The metabolism of Revefenacin can be decreased when combined with Trospium.
DB11915
The metabolism of Valbenazine can be decreased when combined with Trospium.
DB11979
The metabolism of Elagolix can be decreased when combined with Trospium.
DB12070
The metabolism of Letermovir can be decreased when combined with Trospium.
DB12161
The metabolism of Deutetrabenazine can be decreased when combined with Trospium.
DB12212
The metabolism of Landiolol can be decreased when combined with Trospium.
DB12245
The metabolism of Triclabendazole can be decreased when combined with Trospium.
DB12332
The metabolism of Rucaparib can be decreased when combined with Trospium.
DB12752
The metabolism of Bucindolol can be decreased when combined with Trospium.
DB13293
The metabolism of Ipecac can be decreased when combined with Trospium.
DB13443
The metabolism of Esatenolol can be decreased when combined with Trospium.
DB13508
The metabolism of Cloranolol can be decreased when combined with Trospium.
DB13530
The metabolism of Mepindolol can be decreased when combined with Trospium.
DB13679
The metabolism of Dexchlorpheniramine can be decreased when combined with Trospium.
DB13757
The metabolism of Epanolol can be decreased when combined with Trospium.
DB13775
The metabolism of Tertatolol can be decreased when combined with Trospium.
DB06506
The metabolism of Repinotan can be decreased when combined with Trospium.
DB09173
The metabolism of Butyrfentanyl can be decreased when combined with Trospium.
DB11757
The metabolism of Istradefylline can be decreased when combined with Trospium.
DB00238
The metabolism of Nevirapine can be decreased when combined with Trospium.
DB01410
The metabolism of Ciclesonide can be decreased when combined with Trospium.
DB04889
The metabolism of Bicifadine can be decreased when combined with Trospium.
DB11642
The metabolism of Pitolisant can be decreased when combined with Trospium.
DB11718
The metabolism of Encorafenib can be decreased when combined with Trospium.
DB01611
The metabolism of Hydroxychloroquine can be decreased when combined with Trospium.
DB00277
The metabolism of Theophylline can be decreased when combined with Trospium.
DB00489
The metabolism of Sotalol can be decreased when combined with Trospium.
DB00530
The metabolism of Erlotinib can be decreased when combined with Trospium.
DB00637
The metabolism of Astemizole can be decreased when combined with Trospium.
DB00675
The metabolism of Tamoxifen can be decreased when combined with Trospium.
DB01035
The metabolism of Procainamide can be decreased when combined with Trospium.
DB01100
The metabolism of Pimozide can be decreased when combined with Trospium.
DB01195
The metabolism of Flecainide can be decreased when combined with Trospium.
DB05109
The metabolism of Trabectedin can be decreased when combined with Trospium.
DB08901
The metabolism of Ponatinib can be decreased when combined with Trospium.
DB09167
The metabolism of Dosulepin can be decreased when combined with Trospium.
DB11963
The metabolism of Dacomitinib can be decreased when combined with Trospium.
DB13874
The metabolism of Enasidenib can be decreased when combined with Trospium.
DB00458
The metabolism of Trospium can be decreased when combined with Imipramine.
DB00540
The metabolism of Trospium can be decreased when combined with Nortriptyline.
DB00543
The metabolism of Trospium can be decreased when combined with Amoxapine.
DB00575
The metabolism of Trospium can be decreased when combined with Clonidine.
DB00726
The metabolism of Trospium can be decreased when combined with Trimipramine.
DB01151
The metabolism of Trospium can be decreased when combined with Desipramine.
DB01242
The metabolism of Trospium can be decreased when combined with Clomipramine.
DB01235
The absorption of Levodopa can be decreased when combined with Trospium.
DB00455
Trospium may increase the anticholinergic activities of Loratadine.
DB00191
The risk or severity of Tachycardia can be increased when Phentermine is combined with Trospium.
DB00211
The risk or severity of Tachycardia can be increased when Trospium is combined with Midodrine.
DB00217
The risk or severity of Tachycardia can be increased when Trospium is combined with Bethanidine.
DB00221
The risk or severity of Tachycardia can be increased when Trospium is combined with Isoetharine.
DB00261
The risk or severity of Tachycardia can be increased when Trospium is combined with Anagrelide.
DB00368
The risk or severity of Tachycardia can be increased when Trospium is combined with Norepinephrine.
DB00388
The risk or severity of Tachycardia can be increased when Trospium is combined with Phenylephrine.
DB00397
The risk or severity of Tachycardia can be increased when Trospium is combined with Phenylpropanolamine.
DB00598
The risk or severity of Tachycardia can be increased when Trospium is combined with Labetalol.
DB00610
The risk or severity of Tachycardia can be increased when Trospium is combined with Metaraminol.
DB00629
The risk or severity of Tachycardia can be increased when Trospium is combined with Guanabenz.
DB00640
The risk or severity of Tachycardia can be increased when Trospium is combined with Adenosine.
DB00668
The risk or severity of Tachycardia can be increased when Trospium is combined with Epinephrine.
DB00723
The risk or severity of Tachycardia can be increased when Trospium is combined with Methoxamine.
DB00810
The risk or severity of Tachycardia can be increased when Trospium is combined with Biperiden.
DB00816
The risk or severity of Tachycardia can be increased when Trospium is combined with Orciprenaline.
DB00830
The risk or severity of Tachycardia can be increased when Trospium is combined with Phenmetrazine.
DB00841
The risk or severity of Tachycardia can be increased when Trospium is combined with Dobutamine.
DB00852
The risk or severity of Tachycardia can be increased when Trospium is combined with Pseudoephedrine.
DB00867
The risk or severity of Tachycardia can be increased when Trospium is combined with Ritodrine.
DB00901
The risk or severity of Tachycardia can be increased when Trospium is combined with Bitolterol.
DB00935
The risk or severity of Tachycardia can be increased when Trospium is combined with Oxymetazoline.
DB00938
The risk or severity of Tachycardia can be increased when Trospium is combined with Salmeterol.
DB00988
The risk or severity of Tachycardia can be increased when Trospium is combined with Dopamine.
DB01001
The risk or severity of Tachycardia can be increased when Trospium is combined with Salbutamol.
DB01064
The risk or severity of Tachycardia can be increased when Trospium is combined with Isoprenaline.
DB01102
The risk or severity of Tachycardia can be increased when Trospium is combined with Arbutamine.
DB01255
The risk or severity of Tachycardia can be increased when Trospium is combined with Lisdexamfetamine.
DB01291
The risk or severity of Tachycardia can be increased when Trospium is combined with Pirbuterol.
DB01363
The risk or severity of Tachycardia can be increased when Trospium is combined with Ephedra sinica root.
DB01364
The risk or severity of Tachycardia can be increased when Trospium is combined with Ephedrine.
DB01365
The risk or severity of Tachycardia can be increased when Trospium is combined with Mephentermine.
DB01366
The risk or severity of Tachycardia can be increased when Trospium is combined with Procaterol.
DB01407
The risk or severity of Tachycardia can be increased when Trospium is combined with Clenbuterol.
DB01467
The risk or severity of Tachycardia can be increased when Trospium is combined with 2,5-Dimethoxy-4-ethylamphetamine.
DB01556
The risk or severity of Tachycardia can be increased when Trospium is combined with Chlorphentermine.
DB01576
The risk or severity of Tachycardia can be increased when Trospium is combined with Dextroamphetamine.
DB01579
The risk or severity of Tachycardia can be increased when Trospium is combined with Phendimetrazine.
DB05039
The risk or severity of Tachycardia can be increased when Trospium is combined with Indacaterol.
DB05395
The risk or severity of Tachycardia can be increased when Trospium is combined with Amibegron.
DB06152
The risk or severity of Tachycardia can be increased when Trospium is combined with Nylidrin.
DB06190
The risk or severity of Tachycardia can be increased when Trospium is combined with Solabegron.
DB06262
The risk or severity of Tachycardia can be increased when Trospium is combined with Droxidopa.
DB06694
The risk or severity of Tachycardia can be increased when Trospium is combined with Xylometazoline.
DB06706
The risk or severity of Tachycardia can be increased when Trospium is combined with Isometheptene.
DB06707
The risk or severity of Tachycardia can be increased when Trospium is combined with Levonordefrin.
DB06711
The risk or severity of Tachycardia can be increased when Trospium is combined with Naphazoline.
DB06764
The risk or severity of Tachycardia can be increased when Trospium is combined with Tetryzoline.
DB06814
The risk or severity of Tachycardia can be increased when Trospium is combined with Protokylol.
DB08841
The risk or severity of Tachycardia can be increased when Trospium is combined with Tyramine.
DB08925
The risk or severity of Tachycardia can be increased when Trospium is combined with Adrafinil.
DB08941
The risk or severity of Tachycardia can be increased when Trospium is combined with Isoxsuprine.
DB08957
The risk or severity of Tachycardia can be increased when Trospium is combined with Hexoprenaline.
DB08985
The risk or severity of Tachycardia can be increased when Trospium is combined with Etilefrine.
DB09080
The risk or severity of Tachycardia can be increased when Trospium is combined with Olodaterol.
DB09082
The risk or severity of Tachycardia can be increased when Trospium is combined with Vilanterol.
DB09202
The risk or severity of Tachycardia can be increased when Trospium is combined with Cirazoline.
DB09203
The risk or severity of Tachycardia can be increased when Trospium is combined with Synephrine.
DB09242
The risk or severity of Tachycardia can be increased when Trospium is combined with Moxonidine.
DB09273
The risk or severity of Tachycardia can be increased when Trospium is combined with Doxofylline.
DB09480
The risk or severity of Tachycardia can be increased when Trospium is combined with Iofetamine I-123.
DB11124
The risk or severity of Tachycardia can be increased when Trospium is combined with Racepinephrine.
DB11278
The risk or severity of Tachycardia can be increased when Trospium is combined with DL-Methylephedrine.
DB11373
The risk or severity of Tachycardia can be increased when Trospium is combined with Amitraz.
DB11541
The risk or severity of Tachycardia can be increased when Trospium is combined with Ractopamine.
DB11587
The risk or severity of Tachycardia can be increased when Trospium is combined with Etafedrine.
DB11738
The risk or severity of Tachycardia can be increased when Trospium is combined with Rilmenidine.
DB11871
The risk or severity of Tachycardia can be increased when Trospium is combined with PF-00610355.
DB12080
The risk or severity of Tachycardia can be increased when Trospium is combined with Ritobegron.
DB12100
The risk or severity of Tachycardia can be increased when Trospium is combined with Abediterol.
DB12248
The risk or severity of Tachycardia can be increased when Trospium is combined with Tulobuterol.
DB12313
The risk or severity of Tachycardia can be increased when Trospium is combined with Dopexamine.
DB12779
The risk or severity of Tachycardia can be increased when Trospium is combined with Higenamine.
DB12846
The risk or severity of Tachycardia can be increased when Trospium is combined with Reproterol.
DB13064
The risk or severity of Tachycardia can be increased when Trospium is combined with Tramazoline.
DB13108
The risk or severity of Tachycardia can be increased when Trospium is combined with Mephedrone.
DB13139
The risk or severity of Tachycardia can be increased when Trospium is combined with Levosalbutamol.
DB13251
The risk or severity of Tachycardia can be increased when Trospium is combined with Octopamine.
DB13341
The risk or severity of Tachycardia can be increased when Trospium is combined with Fenozolone.
DB13378
The risk or severity of Tachycardia can be increased when Trospium is combined with Norfenefrine.
DB13398
The risk or severity of Tachycardia can be increased when Trospium is combined with Oxyfedrine.
DB13559
The risk or severity of Tachycardia can be increased when Trospium is combined with Rimiterol.
DB13624
The risk or severity of Tachycardia can be increased when Trospium is combined with Methoxyphenamine.
DB13692
The risk or severity of Tachycardia can be increased when Trospium is combined with Tretoquinol.
DB13703
The risk or severity of Tachycardia can be increased when Trospium is combined with Gepefrine.
DB13777
The risk or severity of Tachycardia can be increased when Trospium is combined with Prenalterol.
DB13781
The risk or severity of Tachycardia can be increased when Trospium is combined with Xamoterol.
DB13852
The risk or severity of Tachycardia can be increased when Trospium is combined with Mefenorex.
DB14009
The risk or severity of Tachycardia can be increased when Trospium is combined with Medical Cannabis.
DB01184
The therapeutic efficacy of Domperidone can be decreased when used in combination with Trospium.
DB13074
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Trospium.
DB00321
The metabolism of Amitriptyline can be decreased when combined with Trospium.
DB14754
The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Trospium.
DB00373
The metabolism of Timolol can be decreased when combined with Trospium.
DB00843
The therapeutic efficacy of Trospium can be decreased when used in combination with Donepezil.
DB01233
The therapeutic efficacy of Trospium can be decreased when used in combination with Metoclopramide.
DB00193
The metabolism of Trospium can be decreased when combined with Tramadol.
DB00502
The serum concentration of Trospium can be increased when it is combined with Haloperidol.
DB14881
The risk or severity of urinary retention, reduced gastrointestinal motility, and constipation can be increased when Trospium is combined with Oliceridine.
DB14895
Trospium may increase the smooth muscle relaxing activities of Vibegron.

序列

实验性质

外部标识符

resource：Drugs Product Database (DPD)
identifier：17368
resource：ChEBI
identifier：145791
resource：PubChem Compound
identifier：5284632
resource：PubChem Substance
identifier：46506398
resource：KEGG Drug
identifier：D01103
resource：ChemSpider
identifier：10482307
resource：PharmGKB
identifier：PA164748976
resource：Therapeutic Targets Database
identifier：DAP000342
resource：Wikipedia
identifier：Trospium_chloride
resource：ChEMBL
identifier：CHEMBL1888176
resource：ZINC
identifier：ZINC000100016084
resource：RxCUI
identifier：236778

外部链接

RxList
http://www.rxlist.com/cgi/generic/sanctura.htm
Drugs.com
http://www.drugs.com/cdi/trospium.html

路径

目标

id:BE0000092
name:Muscarinic acetylcholine receptor M1
organism:Humans
action:antagonist
Rovner ES: Trospium chloride in the management of overactive bladder. Drugs. 2004;64(21):2433-46. doi: 10.2165/00003495-200464210-00005.
known-action:unknown
name:Muscarinic acetylcholine receptor M1
general-function:Phosphatidylinositol phospholipase c activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
gene-name:CHRM1
locus:11q13
cellular-location:Cell membrane
transmembrane-regions:25-47 62-82 100-121 142-164 187-209 367-387 402-421
signal-regions:
theoretical-pi:9.67
molecular-weight:51420.375
chromosome-location:11
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1950GenAtlasCHRM1GenBank Gene DatabaseX52068GenBank Protein Database34451IUPHAR13Guide to Pharmacology13UniProtKBP11229UniProt AccessionACM1_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0000184|Muscarinic acetylcholine receptor M1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
gene-sequence:>lcl|BSEQ0009929|Muscarinic acetylcholine receptor M1 (CHRM1) ATGAACACTTCAGCCCCACCTGCTGTCAGCCCCAACATCACCGTCCTGGCACCAGGAAAG GGTCCCTGGCAAGTGGCCTTCATTGGGATCACCACGGGCCTCCTGTCGCTAGCCACAGTG ACAGGCAACCTGCTGGTACTCATCTCTTTCAAGGTCAACACGGAGCTCAAGACAGTCAAT AACTACTTCCTGCTGAGCCTGGCCTGTGCTGACCTCATCATCGGTACCTTCTCCATGAAC CTCTATACCACGTACCTGCTCATGGGCCACTGGGCTCTGGGCACGCTGGCTTGTGACCTC TGGCTGGCCCTGGACTATGTGGCCAGCAATGCCTCCGTCATGAATCTGCTGCTCATCAGC TTTGACCGCTACTTCTCCGTGACTCGGCCCCTGAGCTACCGTGCCAAGCGCACACCCCGC CGGGCAGCTCTGATGATCGGCCTGGCCTGGCTGGTTTCCTTTGTGCTCTGGGCCCCAGCC ATCCTCTTCTGGCAGTACCTGGTAGGGGAGCGGACAGTGCTAGCTGGGCAGTGCTACATC CAGTTCCTCTCCCAGCCCATCATCACCTTTGGCACAGCCATGGCTGCCTTCTACCTCCCT GTCACAGTCATGTGCACGCTCTACTGGCGCATCTACCGGGAGACAGAGAACCGAGCACGG GAGCTGGCAGCCCTTCAGGGCTCCGAGACGCCAGGCAAAGGGGGTGGCAGCAGCAGCAGC TCAGAGAGGTCTCAGCCAGGGGCTGAGGGCTCACCAGAGACTCCTCCAGGCCGCTGCTGT CGCTGCTGCCGGGCCCCCAGGCTGCTGCAGGCCTACAGCTGGAAGGAAGAAGAGGAAGAG GACGAAGGCTCCATGGAGTCCCTCACATCCTCAGAGGGAGAGGAGCCTGGCTCCGAAGTG GTGATCAAGATGCCAATGGTGGACCCCGAGGCACAGGCCCCCACCAAGCAGCCCCCACGG AGCTCCCCAAATACAGTCAAGAGGCCGACTAAGAAAGGGCGTGATCGAGCTGGCAAGGGC CAGAAGCCCCGTGGAAAGGAGCAGCTGGCCAAGCGGAAGACCTTCTCGCTGGTCAAGGAG AAGAAGGCGGCTCGGACCCTGAGTGCCATCCTCCTGGCCTTCATCCTCACCTGGACACCG TACAACATCATGGTGCTGGTGTCCACCTTCTGCAAGGACTGTGTTCCCGAGACCCTGTGG GAGCTGGGCTACTGGCTGTGCTACGTCAACAGCACCATCAACCCCATGTGCTACGCACTC TGCAACAAAGCCTTCCGGGACACCTTTCGCCTGCTGCTGCTTTGCCGCTGGGACAAGAGA CGCTGGCGCAAGATCCCCAAGCGCCCTGGCTCCGTGCACCGCACTCCCTCCCGCCAATGC TGA
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentcell junctioncomponentdendritecomponentintegral component of plasma membranecomponentmembranecomponentplasma membranecomponentpostsynaptic densitycomponentpostsynaptic membranecomponentsynapsefunctiondrug bindingfunctionG-protein coupled acetylcholine receptor activityfunctionphosphatidylinositol phospholipase C activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocesscellular protein modification processprocesscognitionprocessentrainment of circadian clockprocessG-protein coupled acetylcholine receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessnervous system developmentprocessneuromuscular synaptic transmissionprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocessphototransduction, visible lightprocesspositive regulation of cell proliferationprocesspositive regulation of intracellular protein transportprocesspositive regulation of ion transportprocessprotein kinase C-activating G-protein coupled receptor signaling pathwayprocessregulation of locomotionprocesssaliva secretionprocesssensory perception of chemical stimulusprocesssignal transductionprocesssynaptic transmission, cholinergic
id:BE0000045
name:Muscarinic acetylcholine receptor M3
organism:Humans
Hesch K: Agents for treatment of overactive bladder: a therapeutic class review. Proc (Bayl Univ Med Cent). 2007 Jul;20(3):307-14.
known-action:unknown
name:Muscarinic acetylcholine receptor M3
general-function:Receptor activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
gene-name:CHRM3
locus:1q43
cellular-location:Cell membrane
transmembrane-regions:68-91 105-130 143-164 185-206 230-252 492-514 527-546
signal-regions:
theoretical-pi:9.62
molecular-weight:66127.445
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1952GenAtlasCHRM3GenBank Gene DatabaseX15266GenBank Protein Database32324IUPHAR15Guide to Pharmacology15UniProtKBP20309UniProt AccessionACM3_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0009898|Muscarinic acetylcholine receptor M3 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
gene-sequence:>lcl|BSEQ0009899|Muscarinic acetylcholine receptor M3 (CHRM3) ATGACCTTGCACAATAACAGTACAACCTCGCCTTTGTTTCCAAACATCAGCTCCTCCTGG ATACACAGCCCCTCCGATGCAGGGCTGCCCCCGGGAACCGTCACTCATTTCGGCAGCTAC AATGTTTCTCGAGCAGCTGGCAATTTCTCCTCTCCAGACGGTACCACCGATGACCCTCTG GGAGGTCATACCGTCTGGCAAGTGGTCTTCATCGCTTTCTTAACGGGCATCCTGGCCTTG GTGACCATCATCGGCAACATCCTGGTAATTGTGTCATTTAAGGTCAACAAGCAGCTGAAG ACGGTCAACAACTACTTCCTCTTAAGCCTGGCCTGTGCCGATCTGATTATCGGGGTCATT TCAATGAATCTGTTTACGACCTACATCATCATGAATCGATGGGCCTTAGGGAACTTGGCC TGTGACCTCTGGCTTGCCATTGACTACGTAGCCAGCAATGCCTCTGTTATGAATCTTCTG GTCATCAGCTTTGACAGATACTTTTCCATCACGAGGCCGCTCACGTACCGAGCCAAACGA ACAACAAAGAGAGCCGGTGTGATGATCGGTCTGGCTTGGGTCATCTCCTTTGTCCTTTGG GCTCCTGCCATCTTGTTCTGGCAATACTTTGTTGGAAAGAGAACTGTGCCTCCGGGAGAG TGCTTCATTCAGTTCCTCAGTGAGCCCACCATTACTTTTGGCACAGCCATCGCTGCTTTT TATATGCCTGTCACCATTATGACTATTTTATACTGGAGGATCTATAAGGAAACTGAAAAG CGTACCAAAGAGCTTGCTGGCCTGCAAGCCTCTGGGACAGAGGCAGAGACAGAAAACTTT GTCCACCCCACGGGCAGTTCTCGAAGCTGCAGCAGTTACGAACTTCAACAGCAAAGCATG AAACGCTCCAACAGGAGGAAGTATGGCCGCTGCCACTTCTGGTTCACAACCAAGAGCTGG AAACCCAGCTCCGAGCAGATGGACCAAGACCACAGCAGCAGTGACAGTTGGAACAACAAT GATGCTGCTGCCTCCCTGGAGAACTCCGCCTCCTCCGACGAGGAGGACATTGGCTCCGAG ACGAGAGCCATCTACTCCATCGTGCTCAAGCTTCCGGGTCACAGCACCATCCTCAACTCC ACCAAGTTACCCTCATCGGACAACCTGCAGGTGCCTGAGGAGGAGCTGGGGATGGTGGAC TTGGAGAGGAAAGCCGACAAGCTGCAGGCCCAGAAGAGCGTGGACGATGGAGGCAGTTTT CCAAAAAGCTTCTCCAAGCTTCCCATCCAGCTAGAGTCAGCCGTGGACACAGCTAAGACT TCTGACGTCAACTCCTCAGTGGGTAAGAGCACGGCCACTCTACCTCTGTCCTTCAAGGAA GCCACTCTGGCCAAGAGGTTTGCTCTGAAGACCAGAAGTCAGATCACTAAGCGGAAAAGG ATGTCCCTGGTCAAGGAGAAGAAAGCGGCCCAGACCCTCAGTGCGATCTTGCTTGCCTTC ATCATCACTTGGACCCCATACAACATCATGGTTCTGGTGAACACCTTTTGTGACAGCTGC ATACCCAAAACCTTTTGGAATCTGGGCTACTGGCTGTGCTACATCAACAGCACCGTGAAC CCCGTGTGCTATGCTCTGTGCAACAAAACATTCAGAACCACTTTCAAGATGCTGCTGCTG TGCCAGTGTGACAAAAAAAAGAGGCGCAAGCAGCAGTACCAGCAGAGACAGTCGGTCATT TTTCACAAGCGCGCACCCGAGCAGGCCTTGTAG
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentbasolateral plasma membranecomponentcell junctioncomponentdendritecomponentintegral component of plasma membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionacetylcholine bindingfunctiondrug bindingfunctionG-protein coupled acetylcholine receptor activityfunctionphosphatidylinositol phospholipase C activityfunctionreceptor activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocesscellular protein modification processprocessenergy reserve metabolic processprocessG-protein coupled acetylcholine receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessnervous system developmentprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocesspositive regulation of smooth muscle contractionprocessregulation of insulin secretionprocessregulation of vascular smooth muscle contractionprocesssaliva secretionprocesssensory perception of chemical stimulusprocesssignal transductionprocesssmall molecule metabolic processprocesssmooth muscle contractionprocesssynaptic transmission, cholinergic

酶

BE0002363Cytochrome P450 2D6HumansinhibitorA3927910628907Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, Bocker RH, Beckurts KT, Lang W, Fuhr U: Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes. Pharmacol Toxicol. 1999 Dec;85(6):299-304.unknownCytochrome P450 2D6Steroid hydroxylase activityResponsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.CYP2D622q13.1Endoplasmic reticulum membrane7.2655768.9422HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2625GenAtlasCYP2D6GenBank Gene DatabaseM20403GenBank Protein Database181350Guide to Pharmacology1329UniProtKBP10635UniProt AccessionCP2D6_HUMAN1.14.14.1Cholesterol 25-hydroxylaseCYP2DL1CYPIID6Cytochrome P450-DB1Debrisoquine 4-hydroxylase>lcl|BSEQ0004641|Cytochrome P450 2D6 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV FAFLVSPSPYELCAVPR>lcl|BSEQ0019275|Cytochrome P450 2D6 (CYP2D6) ATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATAGTGGCCATCTTCCTGCTCCTGGTG GACCTGATGCACCGGCGCCAACGCTGGGCTGCACGCTACCCACCAGGCCCCCTGCCACTG CCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAGAACACACCATACTGCTTCGACCAG TTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTG CTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTGACCCACGGCGAGGACACCGCCGAC CGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTCGGGCCGCGTTCCCAAGGGGTGTTC CTGGCGCGCTATGGGCCCGCGTGGCGCGAGCAGAGGCGCTTCTCCGTGTCCACCTTGCGC AACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTT TGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTTCGCCCCAACGGTCTCTTGGACAAA GCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGGCGCCGCTTCGAGTACGACGACCCT CGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGACTGAAGGAGGAGTCGGGCTTTCTG CGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCATATCCCAGCGCTGGCTGGCAAGGTC CTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGATGAGCTGCTAACTGAGCACAGGATG ACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACTGAGGCCTTCCTGGCAGAGATGGAG AAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGATGAGAACCTGCGCATAGTGGTGGCT GACCTGTTCTCTGCCGGGATGGTGACCACCTCGACCACGCTGGCCTGGGGCCTCCTGCTC ATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAACAGGAGATCGACGACGTGATAGGG CAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCACATGCCCTACACCACTGCCGTGATT CATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTGGGTGTGACCCATATGACATCCCGT GACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGAACGACACTCATCACCAACCTGTCA TCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCCTTCCGCTTCCACCCCGAACACTTC CTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCCTTCCTGCCTTTCTCAGCAGGCCGC CGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAGCTCTTCCTCTTCTTCACCTCCCTG CTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAGCCCCGGCCCAGCCACCATGGTGTC TTTGCTTTCCTGGTGAGCCCATCCCCCTATGAGCTTTGTGCTGTGCCCCGCTAGPF00067p450componentcytoplasmcomponentendoplasmic reticulumcomponentendoplasmic reticulum membranecomponentmitochondrionfunctionarachidonic acid epoxygenase activityfunctionaromatase activityfunctiondrug bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessalkaloid catabolic processprocessalkaloid metabolic processprocessarachidonic acid metabolic processprocesscoumarin metabolic processprocessdrug catabolic processprocessdrug metabolic processprocessexogenous drug catabolic processprocessheterocycle metabolic processprocessisoquinoline alkaloid metabolic processprocessmonoterpenoid metabolic processprocessnegative regulation of bindingprocessnegative regulation of cellular organofluorine metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid metabolic processprocessxenobiotic metabolic processweak

载体

运输工具

药物反应

效应

不良反应