ID

DB00212|APRD00163||

名称

Remikiren

描述

Remikiren is an orally active, high specificity renin inhibitor.

cas号

126222-34-2

唯一标识码

LC7FBL96A4

状态

solid

组

experimental,

指示

For the treatment of hypertension and heart failure

药效学

Remikiren is an orally available renin inhibitor with an established blood pressure-lowering effect in patients with essential hypertension. No data are available on the renal effects of remikiren in humans. In patients with essential hypertension, a single oral dose of remikiren can induce a renal vasodilation, without affecting the GFR and despite a significant decrease in blood pressure. This systemic and renal hemodynamic response is more pronounced in case of a more activated renin-angiotensin system.

作用机制

Several in vivo experiments have shown that remikiren is specific for renin and does not decrease arterial pressure by an unrelated mechanism.

毒性

代谢

吸收

Absorbed following oral administration.

半衰期

分类

description:This compound belongs to the class of organic compounds known as histidine and derivatives. These are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
direct-parent:Histidine and derivatives
kingdom:Organic compounds
superclass:Organic acids and derivatives
class:Carboxylic acids and derivatives
subclass:Amino acids, peptides, and analogues
alternative-parent:1,2-diols
alternative-parent:Alpha amino acid amides
alternative-parent:Azacyclic compounds
alternative-parent:Benzene and substituted derivatives
alternative-parent:Carbonyl compounds
alternative-parent:Fatty amides
alternative-parent:Heteroaromatic compounds
alternative-parent:Hydrocarbon derivatives
alternative-parent:Imidazoles
alternative-parent:N-acyl-alpha amino acids and derivatives
alternative-parent:Organic oxides
alternative-parent:Organonitrogen compounds
alternative-parent:Organopnictogen compounds
alternative-parent:Secondary alcohols
alternative-parent:Secondary carboxylic acid amides
alternative-parent:Sulfones
substituent:1,2-diol
substituent:Alcohol
substituent:Alpha-amino acid amide
substituent:Aromatic heteromonocyclic compound
substituent:Azacycle
substituent:Azole
substituent:Benzenoid
substituent:Carbonyl group
substituent:Carboxamide group
substituent:Fatty acyl
substituent:Fatty amide
substituent:Heteroaromatic compound
substituent:Histidine or derivatives
substituent:Hydrocarbon derivative
substituent:Imidazole
substituent:Monocyclic benzene moiety
substituent:N-acyl-alpha amino acid or derivatives
substituent:Organic nitrogen compound
substituent:Organic oxide
substituent:Organic oxygen compound
substituent:Organoheterocyclic compound
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound
substituent:Organosulfur compound
substituent:Secondary alcohol
substituent:Secondary carboxylic acid amide
substituent:Sulfone
substituent:Sulfonyl

消除途径

种类

Agents Acting on the Renin-Angiotensin System

Antihypertensive Agents
D000959
Cardiovascular Agents
D002317
Enzyme Inhibitors
D004791
Protease Inhibitors
D011480
Renin-Inhibitors

盐类

蛋白质结合

83%

清除

同义词

language:english; code:inn; name;Remikiren

国际品牌

配送量

产品

混合物

包装者

生产者

价格

受影响的生物体

Humans and other mammals

剂量

atc代码

Renin-inhibitors
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
CARDIOVASCULAR SYSTEM

fda标签

化学品安全技术说明书

专利

食物相互作用

药物相互作用

DB00346
Alfuzosin may increase the hypotensive activities of Remikiren.
DB01143
Remikiren may increase the hypotensive activities of Amifostine.
DB01119
Diazoxide may increase the hypotensive activities of Remikiren.
DB00422
Methylphenidate may decrease the antihypertensive activities of Remikiren.
DB06701
Dexmethylphenidate may decrease the antihypertensive activities of Remikiren.
DB08935
Remikiren may increase the hypotensive activities of Obinutuzumab.
DB00806
Pentoxifylline may increase the hypotensive activities of Remikiren.
DB00073
Remikiren may increase the hypotensive activities of Rituximab.
DB00035
Desmopressin may decrease the antihypertensive activities of Remikiren.
DB00091
Cyclosporine may decrease the antihypertensive activities of Remikiren.
DB00191
Phentermine may decrease the antihypertensive activities of Remikiren.
DB00211
Midodrine may decrease the antihypertensive activities of Remikiren.
DB00216
Eletriptan may decrease the antihypertensive activities of Remikiren.
DB00221
Isoetharine may decrease the antihypertensive activities of Remikiren.
DB00247
Methysergide may decrease the antihypertensive activities of Remikiren.
DB00248
Cabergoline may decrease the antihypertensive activities of Remikiren.
DB00289
Atomoxetine may decrease the antihypertensive activities of Remikiren.
DB00292
Etomidate may decrease the antihypertensive activities of Remikiren.
DB00315
Zolmitriptan may decrease the antihypertensive activities of Remikiren.
DB00320
Dihydroergotamine may decrease the antihypertensive activities of Remikiren.
DB00321
Amitriptyline may decrease the antihypertensive activities of Remikiren.
DB00344
Protriptyline may decrease the antihypertensive activities of Remikiren.
DB00353
Methylergometrine may decrease the antihypertensive activities of Remikiren.
DB00368
Norepinephrine may decrease the antihypertensive activities of Remikiren.
DB00370
Mirtazapine may decrease the antihypertensive activities of Remikiren.
DB00388
Phenylephrine may decrease the antihypertensive activities of Remikiren.
DB00397
Phenylpropanolamine may decrease the antihypertensive activities of Remikiren.
DB00420
Promazine may decrease the antihypertensive activities of Remikiren.
DB00450
Droperidol may decrease the antihypertensive activities of Remikiren.
DB00490
Buspirone may decrease the antihypertensive activities of Remikiren.
DB00540
Nortriptyline may decrease the antihypertensive activities of Remikiren.
DB00543
Amoxapine may decrease the antihypertensive activities of Remikiren.
DB00561
Doxapram may decrease the antihypertensive activities of Remikiren.
DB00572
Atropine may decrease the antihypertensive activities of Remikiren.
DB00589
Lisuride may decrease the antihypertensive activities of Remikiren.
DB00610
Metaraminol may decrease the antihypertensive activities of Remikiren.
DB00656
Trazodone may decrease the antihypertensive activities of Remikiren.
DB00668
Epinephrine may decrease the antihypertensive activities of Remikiren.
DB00669
Sumatriptan may decrease the antihypertensive activities of Remikiren.
DB00696
Ergotamine may decrease the antihypertensive activities of Remikiren.
DB00699
Nicergoline may decrease the antihypertensive activities of Remikiren.
DB00723
Methoxamine may decrease the antihypertensive activities of Remikiren.
DB00726
Trimipramine may decrease the antihypertensive activities of Remikiren.
DB00734
Risperidone may decrease the antihypertensive activities of Remikiren.
DB00777
Propiomazine may decrease the antihypertensive activities of Remikiren.
DB00802
Alfentanil may decrease the antihypertensive activities of Remikiren.
DB00813
Fentanyl may decrease the antihypertensive activities of Remikiren.
DB00816
Orciprenaline may decrease the antihypertensive activities of Remikiren.
DB00830
Phenmetrazine may decrease the antihypertensive activities of Remikiren.
DB00831
Trifluoperazine may decrease the antihypertensive activities of Remikiren.
DB00841
Dobutamine may decrease the antihypertensive activities of Remikiren.
DB00852
Pseudoephedrine may decrease the antihypertensive activities of Remikiren.
DB00865
Benzphetamine may decrease the antihypertensive activities of Remikiren.
DB00867
Ritodrine may decrease the antihypertensive activities of Remikiren.
DB00871
Terbutaline may decrease the antihypertensive activities of Remikiren.
DB00875
Flupentixol may decrease the antihypertensive activities of Remikiren.
DB00901
Bitolterol may decrease the antihypertensive activities of Remikiren.
DB00908
Quinidine may decrease the antihypertensive activities of Remikiren.
DB00918
Almotriptan may decrease the antihypertensive activities of Remikiren.
DB00935
Oxymetazoline may decrease the antihypertensive activities of Remikiren.
DB00937
Diethylpropion may decrease the antihypertensive activities of Remikiren.
DB00938
Salmeterol may decrease the antihypertensive activities of Remikiren.
DB00952
Naratriptan may decrease the antihypertensive activities of Remikiren.
DB00953
Rizatriptan may decrease the antihypertensive activities of Remikiren.
DB00983
Formoterol may decrease the antihypertensive activities of Remikiren.
DB00988
Dopamine may decrease the antihypertensive activities of Remikiren.
DB00998
Frovatriptan may decrease the antihypertensive activities of Remikiren.
DB01001
Salbutamol may decrease the antihypertensive activities of Remikiren.
DB01028
Methoxyflurane may decrease the antihypertensive activities of Remikiren.
DB01049
Ergoloid mesylate may decrease the antihypertensive activities of Remikiren.
DB01064
Isoprenaline may decrease the antihypertensive activities of Remikiren.
DB01102
Arbutamine may decrease the antihypertensive activities of Remikiren.
DB01126
Dutasteride may decrease the antihypertensive activities of Remikiren.
DB01142
Doxepin may decrease the antihypertensive activities of Remikiren.
DB01149
Nefazodone may decrease the antihypertensive activities of Remikiren.
DB01151
Desipramine may decrease the antihypertensive activities of Remikiren.
DB01182
Propafenone may decrease the antihypertensive activities of Remikiren.
DB01186
Pergolide may decrease the antihypertensive activities of Remikiren.
DB01216
Finasteride may decrease the antihypertensive activities of Remikiren.
DB01253
Ergometrine may decrease the antihypertensive activities of Remikiren.
DB01255
Lisdexamfetamine may decrease the antihypertensive activities of Remikiren.
DB01267
Paliperidone may decrease the antihypertensive activities of Remikiren.
DB01274
Arformoterol may decrease the antihypertensive activities of Remikiren.
DB01288
Fenoterol may decrease the antihypertensive activities of Remikiren.
DB01291
Pirbuterol may decrease the antihypertensive activities of Remikiren.
DB01363
Ephedra sinica root may decrease the antihypertensive activities of Remikiren.
DB01364
Ephedrine may decrease the antihypertensive activities of Remikiren.
DB01365
Mephentermine may decrease the antihypertensive activities of Remikiren.
DB01366
Procaterol may decrease the antihypertensive activities of Remikiren.
DB01392
Yohimbine may decrease the antihypertensive activities of Remikiren.
DB01403
Methotrimeprazine may decrease the antihypertensive activities of Remikiren.
DB01407
Clenbuterol may decrease the antihypertensive activities of Remikiren.
DB01408
Bambuterol may decrease the antihypertensive activities of Remikiren.
DB01442
MMDA may decrease the antihypertensive activities of Remikiren.
DB01454
Midomafetamine may decrease the antihypertensive activities of Remikiren.
DB01467
2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Remikiren.
DB01472
4-Methoxyamphetamine may decrease the antihypertensive activities of Remikiren.
DB01484
4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Remikiren.
DB01509
Tenamfetamine may decrease the antihypertensive activities of Remikiren.
DB01556
Chlorphentermine may decrease the antihypertensive activities of Remikiren.
DB01576
Dextroamphetamine may decrease the antihypertensive activities of Remikiren.
DB01577
Metamfetamine may decrease the antihypertensive activities of Remikiren.
DB01579
Phendimetrazine may decrease the antihypertensive activities of Remikiren.
DB01591
Solifenacin may decrease the antihypertensive activities of Remikiren.
DB01608
Periciazine may decrease the antihypertensive activities of Remikiren.
DB01614
Acepromazine may decrease the antihypertensive activities of Remikiren.
DB01622
Thioproperazine may decrease the antihypertensive activities of Remikiren.
DB01624
Zuclopenthixol may decrease the antihypertensive activities of Remikiren.
DB02032
Epicaptopril may decrease the antihypertensive activities of Remikiren.
DB04581
1-benzylimidazole may decrease the antihypertensive activities of Remikiren.
DB04829
Lysergic acid diethylamide may decrease the antihypertensive activities of Remikiren.
DB04836
Amineptine may decrease the antihypertensive activities of Remikiren.
DB04855
Dronedarone may decrease the antihypertensive activities of Remikiren.
DB04908
Flibanserin may decrease the antihypertensive activities of Remikiren.
DB04946
Iloperidone may decrease the antihypertensive activities of Remikiren.
DB05039
Indacaterol may decrease the antihypertensive activities of Remikiren.
DB05395
Amibegron may decrease the antihypertensive activities of Remikiren.
DB05562
Naluzotan may decrease the antihypertensive activities of Remikiren.
DB06016
Cariprazine may decrease the antihypertensive activities of Remikiren.
DB06148
Mianserin may decrease the antihypertensive activities of Remikiren.
DB06152
Nylidrin may decrease the antihypertensive activities of Remikiren.
DB06153
Pizotifen may decrease the antihypertensive activities of Remikiren.
DB06190
Solabegron may decrease the antihypertensive activities of Remikiren.
DB06216
Asenapine may decrease the antihypertensive activities of Remikiren.
DB06262
Droxidopa may decrease the antihypertensive activities of Remikiren.
DB06678
Esmirtazapine may decrease the antihypertensive activities of Remikiren.
DB06684
Vilazodone may decrease the antihypertensive activities of Remikiren.
DB06690
Nitrous oxide may decrease the antihypertensive activities of Remikiren.
DB06694
Xylometazoline may decrease the antihypertensive activities of Remikiren.
DB06706
Isometheptene may decrease the antihypertensive activities of Remikiren.
DB06707
Levonordefrin may decrease the antihypertensive activities of Remikiren.
DB06711
Naphazoline may decrease the antihypertensive activities of Remikiren.
DB06764
Tetryzoline may decrease the antihypertensive activities of Remikiren.
DB08810
Cinitapride may decrease the antihypertensive activities of Remikiren.
DB08815
Lurasidone may decrease the antihypertensive activities of Remikiren.
DB08841
Tyramine may decrease the antihypertensive activities of Remikiren.
DB08893
Mirabegron may decrease the antihypertensive activities of Remikiren.
DB08925
Adrafinil may decrease the antihypertensive activities of Remikiren.
DB08954
Ifenprodil may decrease the antihypertensive activities of Remikiren.
DB08957
Hexoprenaline may decrease the antihypertensive activities of Remikiren.
DB08985
Etilefrine may decrease the antihypertensive activities of Remikiren.
DB08996
Dimetacrine may decrease the antihypertensive activities of Remikiren.
DB09016
Butriptyline may decrease the antihypertensive activities of Remikiren.
DB09061
Cannabidiol may decrease the antihypertensive activities of Remikiren.
DB09068
Vortioxetine may decrease the antihypertensive activities of Remikiren.
DB09080
Olodaterol may decrease the antihypertensive activities of Remikiren.
DB09082
Vilanterol may decrease the antihypertensive activities of Remikiren.
DB09128
Brexpiprazole may decrease the antihypertensive activities of Remikiren.
DB09167
Dosulepin may decrease the antihypertensive activities of Remikiren.
DB09202
Cirazoline may decrease the antihypertensive activities of Remikiren.
DB09203
Synephrine may decrease the antihypertensive activities of Remikiren.
DB09205
Moxisylyte may decrease the antihypertensive activities of Remikiren.
DB09289
Tianeptine may decrease the antihypertensive activities of Remikiren.
DB09307
Oxaprotiline may decrease the antihypertensive activities of Remikiren.
DB09480
Iofetamine I-123 may decrease the antihypertensive activities of Remikiren.
DB11124
Racepinephrine may decrease the antihypertensive activities of Remikiren.
DB11273
Dihydroergocornine may decrease the antihypertensive activities of Remikiren.
DB11278
DL-Methylephedrine may decrease the antihypertensive activities of Remikiren.
DB11373
Amitraz may decrease the antihypertensive activities of Remikiren.
DB11428
Medetomidine may decrease the antihypertensive activities of Remikiren.
DB11477
Xylazine may decrease the antihypertensive activities of Remikiren.
DB11481
Atipamezole may decrease the antihypertensive activities of Remikiren.
DB11541
Ractopamine may decrease the antihypertensive activities of Remikiren.
DB11543
Romifidine may decrease the antihypertensive activities of Remikiren.
DB11556
Detomidine may decrease the antihypertensive activities of Remikiren.
DB11587
Etafedrine may decrease the antihypertensive activities of Remikiren.
DB11755
Tetrahydrocannabivarin may decrease the antihypertensive activities of Remikiren.
DB11785
Anisodamine may decrease the antihypertensive activities of Remikiren.
DB11871
PF-00610355 may decrease the antihypertensive activities of Remikiren.
DB12080
Ritobegron may decrease the antihypertensive activities of Remikiren.
DB12100
Abediterol may decrease the antihypertensive activities of Remikiren.
DB12248
Tulobuterol may decrease the antihypertensive activities of Remikiren.
DB12278
Propiverine may decrease the antihypertensive activities of Remikiren.
DB12313
Dopexamine may decrease the antihypertensive activities of Remikiren.
DB12361
Piclozotan may decrease the antihypertensive activities of Remikiren.
DB12371
Siponimod may decrease the antihypertensive activities of Remikiren.
DB12551
Idazoxan may decrease the antihypertensive activities of Remikiren.
DB12779
Higenamine may decrease the antihypertensive activities of Remikiren.
DB12846
Reproterol may decrease the antihypertensive activities of Remikiren.
DB12927
Theodrenaline may decrease the antihypertensive activities of Remikiren.
DB12930
Opipramol may decrease the antihypertensive activities of Remikiren.
DB13064
Tramazoline may decrease the antihypertensive activities of Remikiren.
DB13108
Mephedrone may decrease the antihypertensive activities of Remikiren.
DB13114
Amitriptylinoxide may decrease the antihypertensive activities of Remikiren.
DB13139
Levosalbutamol may decrease the antihypertensive activities of Remikiren.
DB13225
Dibenzepin may decrease the antihypertensive activities of Remikiren.
DB13246
Quinupramine may decrease the antihypertensive activities of Remikiren.
DB13251
Octopamine may decrease the antihypertensive activities of Remikiren.
DB13323
Trichloroethylene may decrease the antihypertensive activities of Remikiren.
DB13341
Fenozolone may decrease the antihypertensive activities of Remikiren.
DB13345
Dihydroergocristine may decrease the antihypertensive activities of Remikiren.
DB13378
Norfenefrine may decrease the antihypertensive activities of Remikiren.
DB13384
Melitracen may decrease the antihypertensive activities of Remikiren.
DB13385
Dihydroergocryptine may decrease the antihypertensive activities of Remikiren.
DB13398
Oxyfedrine may decrease the antihypertensive activities of Remikiren.
DB13399
Terguride may decrease the antihypertensive activities of Remikiren.
DB13411
Lofepramine may decrease the antihypertensive activities of Remikiren.
DB13453
Xenon may decrease the antihypertensive activities of Remikiren.
DB13496
Iprindole may decrease the antihypertensive activities of Remikiren.
DB13510
Buflomedil may decrease the antihypertensive activities of Remikiren.
DB13520
Metergoline may decrease the antihypertensive activities of Remikiren.
DB13559
Rimiterol may decrease the antihypertensive activities of Remikiren.
DB13598
Diethyl ether may decrease the antihypertensive activities of Remikiren.
DB13624
Methoxyphenamine may decrease the antihypertensive activities of Remikiren.
DB13692
Tretoquinol may decrease the antihypertensive activities of Remikiren.
DB13703
Gepefrine may decrease the antihypertensive activities of Remikiren.
DB13777
Prenalterol may decrease the antihypertensive activities of Remikiren.
DB13781
Xamoterol may decrease the antihypertensive activities of Remikiren.
DB13782
Imipramine oxide may decrease the antihypertensive activities of Remikiren.
DB13852
Mefenorex may decrease the antihypertensive activities of Remikiren.
DB13917
Deoxyepinephrine may decrease the antihypertensive activities of Remikiren.
DB13940
2,5-Dimethoxy-4-ethylthioamphetamine may decrease the antihypertensive activities of Remikiren.
DB14010
5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Remikiren.
DB14231
Quinoline Yellow WS may decrease the antihypertensive activities of Remikiren.
DB14754
Solriamfetol may decrease the antihypertensive activities of Remikiren.
DB00363
Clozapine may decrease the antihypertensive activities of Remikiren.
DB00458
Imipramine may decrease the antihypertensive activities of Remikiren.
DB00477
Chlorpromazine may decrease the antihypertensive activities of Remikiren.
DB00633
Dexmedetomidine may decrease the antihypertensive activities of Remikiren.
DB00679
Thioridazine may decrease the antihypertensive activities of Remikiren.
DB00692
Phentolamine may decrease the antihypertensive activities of Remikiren.
DB00708
Sufentanil may decrease the antihypertensive activities of Remikiren.
DB00753
Isoflurane may decrease the antihypertensive activities of Remikiren.
DB00797
Tolazoline may decrease the antihypertensive activities of Remikiren.
DB00818
Propofol may decrease the antihypertensive activities of Remikiren.
DB00899
Remifentanil may decrease the antihypertensive activities of Remikiren.
DB00925
Phenoxybenzamine may decrease the antihypertensive activities of Remikiren.
DB01018
Guanfacine may decrease the antihypertensive activities of Remikiren.
DB01159
Halothane may decrease the antihypertensive activities of Remikiren.
DB01189
Desflurane may decrease the antihypertensive activities of Remikiren.
DB01200
Bromocriptine may decrease the antihypertensive activities of Remikiren.
DB01236
Sevoflurane may decrease the antihypertensive activities of Remikiren.
DB01242
Clomipramine may decrease the antihypertensive activities of Remikiren.
DB04948
Lofexidine may decrease the antihypertensive activities of Remikiren.
DB05271
Rotigotine may decrease the antihypertensive activities of Remikiren.
DB08941
Isoxsuprine may decrease the antihypertensive activities of Remikiren.
DB08950
Indoramin may decrease the antihypertensive activities of Remikiren.
DB09242
Moxonidine may decrease the antihypertensive activities of Remikiren.
DB00945
Acetylsalicylic acid may decrease the antihypertensive activities of Remikiren.
DB15685
Selpercatinib may decrease the antihypertensive activities of Remikiren.
DB15965
Naxitamab may decrease the antihypertensive activities of Remikiren.
DB09282
Molsidomine may increase the hypotensive activities of Remikiren.
DB00217
Remikiren may increase the hypotensive activities of Bethanidine.
DB00226
Remikiren may increase the hypotensive activities of Guanadrel.
DB00287
Remikiren may increase the hypotensive activities of Travoprost.
DB00521
Remikiren may increase the hypotensive activities of Carteolol.
DB00559
Remikiren may increase the hypotensive activities of Bosentan.
DB00616
Remikiren may increase the hypotensive activities of Candoxatril.
DB00629
Remikiren may increase the hypotensive activities of Guanabenz.
DB00765
Remikiren may increase the hypotensive activities of Metyrosine.
DB00785
Remikiren may increase the hypotensive activities of Cryptenamine.
DB00866
Remikiren may increase the hypotensive activities of Alprenolol.
DB00869
Remikiren may increase the hypotensive activities of Dorzolamide.
DB00886
Remikiren may increase the hypotensive activities of Omapatrilat.
DB00905
Remikiren may increase the hypotensive activities of Bimatoprost.
DB01089
Remikiren may increase the hypotensive activities of Deserpidine.
DB01090
Remikiren may increase the hypotensive activities of Pentolinium.
DB01116
Remikiren may increase the hypotensive activities of Trimethaphan.
DB01170
Remikiren may increase the hypotensive activities of Guanethidine.
DB01180
Remikiren may increase the hypotensive activities of Rescinnamine.
DB01214
Remikiren may increase the hypotensive activities of Metipranolol.
DB01295
Remikiren may increase the hypotensive activities of Bevantolol.
DB01297
Remikiren may increase the hypotensive activities of Practolol.
DB01348
Remikiren may increase the hypotensive activities of Spirapril.
DB01388
Remikiren may increase the hypotensive activities of Mibefradil.
DB03322
Remikiren may increase the hypotensive activities of Dexpropranolol.
DB04831
Remikiren may increase the hypotensive activities of Tienilic acid.
DB04840
Remikiren may increase the hypotensive activities of Debrisoquine.
DB04846
Remikiren may increase the hypotensive activities of Celiprolol.
DB06268
Remikiren may increase the hypotensive activities of Sitaxentan.
DB06403
Remikiren may increase the hypotensive activities of Ambrisentan.
DB06445
Remikiren may increase the hypotensive activities of Diethylnorspermine.
DB06762
Remikiren may increase the hypotensive activities of Pinacidil.
DB06826
Remikiren may increase the hypotensive activities of Unoprostone.
DB07767
Remikiren may increase the hypotensive activities of Ferulic acid.
DB08808
Remikiren may increase the hypotensive activities of Bupranolol.
DB08836
Remikiren may increase the hypotensive activities of Temocapril.
DB08932
Remikiren may increase the hypotensive activities of Macitentan.
DB08952
Remikiren may increase the hypotensive activities of Indenolol.
DB08960
Remikiren may increase the hypotensive activities of Hexamethonium.
DB09206
Remikiren may increase the hypotensive activities of Trimazosin.
DB09220
Remikiren may increase the hypotensive activities of Nicorandil.
DB09238
Remikiren may increase the hypotensive activities of Manidipine.
DB09239
Remikiren may increase the hypotensive activities of Niguldipine.
DB09363
Remikiren may increase the hypotensive activities of Rauwolfia serpentina root.
DB11362
Remikiren may increase the hypotensive activities of Selexipag.
DB11720
Remikiren may increase the hypotensive activities of Angiotensin 1-7.
DB11738
Remikiren may increase the hypotensive activities of Rilmenidine.
DB11770
Remikiren may increase the hypotensive activities of Talinolol.
DB12054
Remikiren may increase the hypotensive activities of BQ-123.
DB12092
Remikiren may increase the hypotensive activities of Naftopidil.
DB12093
Remikiren may increase the hypotensive activities of Tetrahydropalmatine.
DB12212
Remikiren may increase the hypotensive activities of Landiolol.
DB12465
Remikiren may increase the hypotensive activities of Ketanserin.
DB12661
Remikiren may increase the hypotensive activities of Urapidil.
DB12766
Remikiren may increase the hypotensive activities of Cicletanine.
DB12945
Remikiren may increase the hypotensive activities of Dihydralazine.
DB13166
Remikiren may increase the hypotensive activities of Zofenopril.
DB13211
Remikiren may increase the hypotensive activities of Guanoxan.
DB13312
Remikiren may increase the hypotensive activities of Delapril.
DB13374
Remikiren may increase the hypotensive activities of Vincamine.
DB13400
Remikiren may increase the hypotensive activities of Linsidomine.
DB13410
Remikiren may increase the hypotensive activities of Guanoxabenz.
DB13429
Remikiren may increase the hypotensive activities of Tolonidine.
DB13435
Remikiren may increase the hypotensive activities of Endralazine.
DB13443
Remikiren may increase the hypotensive activities of Esatenolol.
DB13452
Remikiren may increase the hypotensive activities of Cadralazine.
DB13508
Remikiren may increase the hypotensive activities of Cloranolol.
DB13575
Remikiren may increase the hypotensive activities of Bietaserpine.
DB13604
Remikiren may increase the hypotensive activities of Guanazodine.
DB13631
Remikiren may increase the hypotensive activities of Methoserpidine.
DB13757
Remikiren may increase the hypotensive activities of Epanolol.
DB13779
Remikiren may increase the hypotensive activities of Guanoclor.
DB13801
Remikiren may increase the hypotensive activities of Muzolimine.
DB13803
Remikiren may increase the hypotensive activities of Xipamide.
DB14068
Remikiren may increase the hypotensive activities of Dexniguldipine.
DB14094
Remikiren may increase the hypotensive activities of Tocopherylquinone.
DB14125
Remikiren may increase the hypotensive activities of Benazeprilat.
DB14207
Remikiren may increase the hypotensive activities of Fosinoprilat.
DB14208
Remikiren may increase the hypotensive activities of Ramiprilat.
DB14213
Remikiren may increase the hypotensive activities of Perindoprilat.
DB14217
Remikiren may increase the hypotensive activities of Quinaprilat.
DB00178
Ramipril may increase the hypotensive activities of Remikiren.
DB00187
Esmolol may increase the hypotensive activities of Remikiren.
DB00195
Betaxolol may increase the hypotensive activities of Remikiren.
DB00206
Reserpine may increase the hypotensive activities of Remikiren.
DB00214
Torasemide may increase the hypotensive activities of Remikiren.
DB00264
Metoprolol may increase the hypotensive activities of Remikiren.
DB00270
Isradipine may increase the hypotensive activities of Remikiren.
DB00310
Chlorthalidone may increase the hypotensive activities of Remikiren.
DB00325
Nitroprusside may increase the hypotensive activities of Remikiren.
DB00335
Atenolol may increase the hypotensive activities of Remikiren.
DB00343
Diltiazem may increase the hypotensive activities of Remikiren.
DB00350
Minoxidil may increase the hypotensive activities of Remikiren.
DB00373
Timolol may increase the hypotensive activities of Remikiren.
DB00381
Amlodipine may increase the hypotensive activities of Remikiren.
DB00393
Nimodipine may increase the hypotensive activities of Remikiren.
DB00401
Nisoldipine may increase the hypotensive activities of Remikiren.
DB00492
Fosinopril may increase the hypotensive activities of Remikiren.
DB00519
Trandolapril may increase the hypotensive activities of Remikiren.
DB00524
Metolazone may increase the hypotensive activities of Remikiren.
DB00528
Lercanidipine may increase the hypotensive activities of Remikiren.
DB00542
Benazepril may increase the hypotensive activities of Remikiren.
DB00571
Propranolol may increase the hypotensive activities of Remikiren.
DB00584
Enalapril may increase the hypotensive activities of Remikiren.
DB00590
Doxazosin may increase the hypotensive activities of Remikiren.
DB00598
Labetalol may increase the hypotensive activities of Remikiren.
DB00612
Bisoprolol may increase the hypotensive activities of Remikiren.
DB00622
Nicardipine may increase the hypotensive activities of Remikiren.
DB00657
Mecamylamine may increase the hypotensive activities of Remikiren.
DB00691
Moexipril may increase the hypotensive activities of Remikiren.
DB00695
Furosemide may increase the hypotensive activities of Remikiren.
DB00700
Eplerenone may increase the hypotensive activities of Remikiren.
DB00722
Lisinopril may increase the hypotensive activities of Remikiren.
DB00727
Nitroglycerin may increase the hypotensive activities of Remikiren.
DB00790
Perindopril may increase the hypotensive activities of Remikiren.
DB00800
Fenoldopam may increase the hypotensive activities of Remikiren.
DB00881
Quinapril may increase the hypotensive activities of Remikiren.
DB00960
Pindolol may increase the hypotensive activities of Remikiren.
DB00968
Methyldopa may increase the hypotensive activities of Remikiren.
DB01023
Felodipine may increase the hypotensive activities of Remikiren.
DB01054
Nitrendipine may increase the hypotensive activities of Remikiren.
DB01136
Carvedilol may increase the hypotensive activities of Remikiren.
DB01158
Bretylium may increase the hypotensive activities of Remikiren.
DB01162
Terazosin may increase the hypotensive activities of Remikiren.
DB01193
Acebutolol may increase the hypotensive activities of Remikiren.
DB01197
Captopril may increase the hypotensive activities of Remikiren.
DB01203
Nadolol may increase the hypotensive activities of Remikiren.
DB01244
Bepridil may increase the hypotensive activities of Remikiren.
DB01275
Hydralazine may increase the hypotensive activities of Remikiren.
DB01340
Cilazapril may increase the hypotensive activities of Remikiren.
DB01359
Penbutolol may increase the hypotensive activities of Remikiren.
DB01580
Oxprenolol may increase the hypotensive activities of Remikiren.
DB04861
Nebivolol may increase the hypotensive activities of Remikiren.
DB06712
Nilvadipine may increase the hypotensive activities of Remikiren.
DB08931
Riociguat may increase the hypotensive activities of Remikiren.
DB09026
Aliskiren may increase the hypotensive activities of Remikiren.
DB09235
Efonidipine may increase the hypotensive activities of Remikiren.
DB09236
Lacidipine may increase the hypotensive activities of Remikiren.
DB09477
Enalaprilat may increase the hypotensive activities of Remikiren.
DB11783
Imidapril may increase the hypotensive activities of Remikiren.
DB09237
Remikiren may increase the hypotensive activities of Levamlodipine.
DB00484
Brimonidine may increase the antihypertensive activities of Remikiren.
DB00203
Sildenafil may increase the antihypertensive activities of Remikiren.
DB00235
Milrinone may increase the antihypertensive activities of Remikiren.
DB00820
Tadalafil may increase the antihypertensive activities of Remikiren.
DB00862
Vardenafil may increase the antihypertensive activities of Remikiren.
DB00975
Dipyridamole may increase the antihypertensive activities of Remikiren.
DB05266
Ibudilast may increase the antihypertensive activities of Remikiren.
DB06237
Avanafil may increase the antihypertensive activities of Remikiren.
DB06267
Udenafil may increase the antihypertensive activities of Remikiren.
DB09273
Doxofylline may increase the antihypertensive activities of Remikiren.
DB11792
Mirodenafil may increase the antihypertensive activities of Remikiren.
DB12010
Fostamatinib may increase the antihypertensive activities of Remikiren.
DB00374
Treprostinil may increase the hypotensive activities of Remikiren.
DB01088
Iloprost may increase the hypotensive activities of Remikiren.
DB01240
Epoprostenol may increase the hypotensive activities of Remikiren.
DB00468
Quinine may increase the hypotensive activities of Remikiren.
DB14337
Salvia miltiorrhiza root may increase the hypotensive activities of Remikiren.
DB00182
Amphetamine may increase the hypotensive activities of Remikiren.
DB00601
Linezolid may increase the hypotensive activities of Remikiren.
DB00614
Furazolidone may increase the hypotensive activities of Remikiren.
DB00721
Procaine may increase the hypotensive activities of Remikiren.
DB00752
Tranylcypromine may increase the hypotensive activities of Remikiren.
DB00780
Phenelzine may increase the hypotensive activities of Remikiren.
DB00805
Minaprine may increase the hypotensive activities of Remikiren.
DB01037
Selegiline may increase the hypotensive activities of Remikiren.
DB01168
Procarbazine may increase the hypotensive activities of Remikiren.
DB01171
Moclobemide may increase the hypotensive activities of Remikiren.
DB01247
Isocarboxazid may increase the hypotensive activities of Remikiren.
DB01367
Rasagiline may increase the hypotensive activities of Remikiren.
DB01626
Pargyline may increase the hypotensive activities of Remikiren.
DB04017
Clorgiline may increase the hypotensive activities of Remikiren.
DB04818
Iproniazid may increase the hypotensive activities of Remikiren.
DB04820
Nialamide may increase the hypotensive activities of Remikiren.
DB06654
Safinamide may increase the hypotensive activities of Remikiren.
DB08550
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Remikiren.
DB09241
Methylene blue may increase the hypotensive activities of Remikiren.
DB09243
Hydracarbazine may increase the hypotensive activities of Remikiren.
DB09244
Pirlindole may increase the hypotensive activities of Remikiren.
DB09245
Toloxatone may increase the hypotensive activities of Remikiren.
DB09246
Benmoxin may increase the hypotensive activities of Remikiren.
DB09248
Mebanazine may increase the hypotensive activities of Remikiren.
DB09249
Octamoxin may increase the hypotensive activities of Remikiren.
DB09250
Pheniprazine may increase the hypotensive activities of Remikiren.
DB09251
Phenoxypropazine may increase the hypotensive activities of Remikiren.
DB09252
Pivhydrazine may increase the hypotensive activities of Remikiren.
DB09253
Safrazine may increase the hypotensive activities of Remikiren.
DB09254
Caroxazone may increase the hypotensive activities of Remikiren.
DB13875
Harmaline may increase the hypotensive activities of Remikiren.
DB13876
Brofaromine may increase the hypotensive activities of Remikiren.
DB09449
The risk or severity of nephrotoxicity can be increased when Remikiren is combined with Sodium phosphate, monobasic.
DB00177
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Valsartan.
DB00275
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Olmesartan.
DB00678
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Losartan.
DB00796
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Candesartan cilexetil.
DB00876
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Eprosartan.
DB00966
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Telmisartan.
DB01029
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Irbesartan.
DB01342
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Forasartan.
DB01347
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Saprisartan.
DB01349
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Tasosartan.
DB06763
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Saralasin.
DB08822
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Azilsartan medoxomil.
DB09279
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Fimasartan.
DB13919
The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Remikiren is combined with Candesartan.
DB00159
The therapeutic efficacy of Remikiren can be decreased when used in combination with Icosapent.
DB00244
The therapeutic efficacy of Remikiren can be decreased when used in combination with Mesalazine.
DB00328
The therapeutic efficacy of Remikiren can be decreased when used in combination with Indomethacin.
DB00461
The therapeutic efficacy of Remikiren can be decreased when used in combination with Nabumetone.
DB00465
The therapeutic efficacy of Remikiren can be decreased when used in combination with Ketorolac.
DB00469
The therapeutic efficacy of Remikiren can be decreased when used in combination with Tenoxicam.
DB00482
The therapeutic efficacy of Remikiren can be decreased when used in combination with Celecoxib.
DB00500
The therapeutic efficacy of Remikiren can be decreased when used in combination with Tolmetin.
DB00533
The therapeutic efficacy of Remikiren can be decreased when used in combination with Rofecoxib.
DB00554
The therapeutic efficacy of Remikiren can be decreased when used in combination with Piroxicam.
DB00573
The therapeutic efficacy of Remikiren can be decreased when used in combination with Fenoprofen.
DB00580
The therapeutic efficacy of Remikiren can be decreased when used in combination with Valdecoxib.
DB00586
The therapeutic efficacy of Remikiren can be decreased when used in combination with Diclofenac.
DB00605
The therapeutic efficacy of Remikiren can be decreased when used in combination with Sulindac.
DB00712
The therapeutic efficacy of Remikiren can be decreased when used in combination with Flurbiprofen.
DB00749
The therapeutic efficacy of Remikiren can be decreased when used in combination with Etodolac.
DB00784
The therapeutic efficacy of Remikiren can be decreased when used in combination with Mefenamic acid.
DB00788
The therapeutic efficacy of Remikiren can be decreased when used in combination with Naproxen.
DB00795
The therapeutic efficacy of Remikiren can be decreased when used in combination with Sulfasalazine.
DB00812
The therapeutic efficacy of Remikiren can be decreased when used in combination with Phenylbutazone.
DB00814
The therapeutic efficacy of Remikiren can be decreased when used in combination with Meloxicam.
DB00821
The therapeutic efficacy of Remikiren can be decreased when used in combination with Carprofen.
DB00861
The therapeutic efficacy of Remikiren can be decreased when used in combination with Diflunisal.
DB00936
The therapeutic efficacy of Remikiren can be decreased when used in combination with Salicylic acid.
DB00939
The therapeutic efficacy of Remikiren can be decreased when used in combination with Meclofenamic acid.
DB00991
The therapeutic efficacy of Remikiren can be decreased when used in combination with Oxaprozin.
DB01009
The therapeutic efficacy of Remikiren can be decreased when used in combination with Ketoprofen.
DB01014
The therapeutic efficacy of Remikiren can be decreased when used in combination with Balsalazide.
DB01050
The therapeutic efficacy of Remikiren can be decreased when used in combination with Ibuprofen.
DB01250
The therapeutic efficacy of Remikiren can be decreased when used in combination with Olsalazine.
DB01283
The therapeutic efficacy of Remikiren can be decreased when used in combination with Lumiracoxib.
DB01397
The therapeutic efficacy of Remikiren can be decreased when used in combination with Magnesium salicylate.
DB01399
The therapeutic efficacy of Remikiren can be decreased when used in combination with Salsalate.
DB01401
The therapeutic efficacy of Remikiren can be decreased when used in combination with Choline magnesium trisalicylate.
DB01419
The therapeutic efficacy of Remikiren can be decreased when used in combination with Antrafenine.
DB01424
The therapeutic efficacy of Remikiren can be decreased when used in combination with Aminophenazone.
DB01435
The therapeutic efficacy of Remikiren can be decreased when used in combination with Antipyrine.
DB01600
The therapeutic efficacy of Remikiren can be decreased when used in combination with Tiaprofenic acid.
DB01628
The therapeutic efficacy of Remikiren can be decreased when used in combination with Etoricoxib.
DB02224
The therapeutic efficacy of Remikiren can be decreased when used in combination with Taxifolin.
DB03585
The therapeutic efficacy of Remikiren can be decreased when used in combination with Oxyphenbutazone.
DB04725
The therapeutic efficacy of Remikiren can be decreased when used in combination with Licofelone.
DB04743
The therapeutic efficacy of Remikiren can be decreased when used in combination with Nimesulide.
DB04812
The therapeutic efficacy of Remikiren can be decreased when used in combination with Benoxaprofen.
DB04817
The therapeutic efficacy of Remikiren can be decreased when used in combination with Metamizole.
DB04828
The therapeutic efficacy of Remikiren can be decreased when used in combination with Zomepirac.
DB05095
The therapeutic efficacy of Remikiren can be decreased when used in combination with Cimicoxib.
DB06725
The therapeutic efficacy of Remikiren can be decreased when used in combination with Lornoxicam.
DB06736
The therapeutic efficacy of Remikiren can be decreased when used in combination with Aceclofenac.
DB06737
The therapeutic efficacy of Remikiren can be decreased when used in combination with Zaltoprofen.
DB07402
The therapeutic efficacy of Remikiren can be decreased when used in combination with Azapropazone.
DB08439
The therapeutic efficacy of Remikiren can be decreased when used in combination with Parecoxib.
DB08797
The therapeutic efficacy of Remikiren can be decreased when used in combination with Salicylamide.
DB08940
The therapeutic efficacy of Remikiren can be decreased when used in combination with Kebuzone.
DB08942
The therapeutic efficacy of Remikiren can be decreased when used in combination with Isoxicam.
DB08951
The therapeutic efficacy of Remikiren can be decreased when used in combination with Indoprofen.
DB08955
The therapeutic efficacy of Remikiren can be decreased when used in combination with Ibuproxam.
DB08976
The therapeutic efficacy of Remikiren can be decreased when used in combination with Floctafenine.
DB08981
The therapeutic efficacy of Remikiren can be decreased when used in combination with Fenbufen.
DB08984
The therapeutic efficacy of Remikiren can be decreased when used in combination with Etofenamate.
DB08991
The therapeutic efficacy of Remikiren can be decreased when used in combination with Epirizole.
DB09084
The therapeutic efficacy of Remikiren can be decreased when used in combination with Benzydamine.
DB09213
The therapeutic efficacy of Remikiren can be decreased when used in combination with Dexibuprofen.
DB09214
The therapeutic efficacy of Remikiren can be decreased when used in combination with Dexketoprofen.
DB09215
The therapeutic efficacy of Remikiren can be decreased when used in combination with Droxicam.
DB09216
The therapeutic efficacy of Remikiren can be decreased when used in combination with Tolfenamic acid.
DB09217
The therapeutic efficacy of Remikiren can be decreased when used in combination with Firocoxib.
DB09218
The therapeutic efficacy of Remikiren can be decreased when used in combination with Clonixin.
DB09285
The therapeutic efficacy of Remikiren can be decreased when used in combination with Morniflumate.
DB09288
The therapeutic efficacy of Remikiren can be decreased when used in combination with Propacetamol.
DB09295
The therapeutic efficacy of Remikiren can be decreased when used in combination with Talniflumate.
DB11455
The therapeutic efficacy of Remikiren can be decreased when used in combination with Robenacoxib.
DB11466
The therapeutic efficacy of Remikiren can be decreased when used in combination with Tepoxalin.
DB11518
The therapeutic efficacy of Remikiren can be decreased when used in combination with Flunixin.
DB12399
The therapeutic efficacy of Remikiren can be decreased when used in combination with Polmacoxib.
DB12445
The therapeutic efficacy of Remikiren can be decreased when used in combination with Nitroaspirin.
DB12545
The therapeutic efficacy of Remikiren can be decreased when used in combination with Indobufen.
DB12610
The therapeutic efficacy of Remikiren can be decreased when used in combination with Ebselen.
DB13001
The therapeutic efficacy of Remikiren can be decreased when used in combination with Tinoridine.
DB13167
The therapeutic efficacy of Remikiren can be decreased when used in combination with Alclofenac.
DB13217
The therapeutic efficacy of Remikiren can be decreased when used in combination with Fentiazac.
DB13232
The therapeutic efficacy of Remikiren can be decreased when used in combination with Suxibuzone.
DB13286
The therapeutic efficacy of Remikiren can be decreased when used in combination with Bumadizone.
DB13314
The therapeutic efficacy of Remikiren can be decreased when used in combination with Alminoprofen.
DB13371
The therapeutic efficacy of Remikiren can be decreased when used in combination with Difenpiramide.
DB13407
The therapeutic efficacy of Remikiren can be decreased when used in combination with Nifenazone.
DB13432
The therapeutic efficacy of Remikiren can be decreased when used in combination with Lonazolac.
DB13481
The therapeutic efficacy of Remikiren can be decreased when used in combination with Tenidap.
DB13524
The therapeutic efficacy of Remikiren can be decreased when used in combination with Propyphenazone.
DB13527
The therapeutic efficacy of Remikiren can be decreased when used in combination with Proglumetacin.
DB13538
The therapeutic efficacy of Remikiren can be decreased when used in combination with Guacetisal.
DB13544
The therapeutic efficacy of Remikiren can be decreased when used in combination with Ethenzamide.
DB13612
The therapeutic efficacy of Remikiren can be decreased when used in combination with Carbaspirin calcium.
DB13629
The therapeutic efficacy of Remikiren can be decreased when used in combination with Mofebutazone.
DB13649
The therapeutic efficacy of Remikiren can be decreased when used in combination with Proquazone.
DB13657
The therapeutic efficacy of Remikiren can be decreased when used in combination with Benorilate.
DB13722
The therapeutic efficacy of Remikiren can be decreased when used in combination with Pirprofen.
DB13783
The therapeutic efficacy of Remikiren can be decreased when used in combination with Acemetacin.
DB13860
The therapeutic efficacy of Remikiren can be decreased when used in combination with Imidazole salicylate.
DB14059
The therapeutic efficacy of Remikiren can be decreased when used in combination with SC-236.
DB14060
The therapeutic efficacy of Remikiren can be decreased when used in combination with NS-398.
DB14938
The therapeutic efficacy of Remikiren can be decreased when used in combination with Flurbiprofen axetil.
DB09212
The therapeutic efficacy of Remikiren can be decreased when used in combination with Loxoprofen.
DB09227
Remikiren may increase the antihypertensive activities of Barnidipine.
DB00181
The risk or severity of adverse effects can be increased when Baclofen is combined with Remikiren.
DB00190
The risk or severity of hypotension can be increased when Carbidopa is combined with Remikiren.
DB00457
The risk or severity of hypotension can be increased when Prazosin is combined with Remikiren.
DB00041
Aldesleukin may increase the hypotensive activities of Remikiren.
DB00086
Streptokinase may increase the hypotensive activities of Remikiren.
DB00268
Ropinirole may increase the hypotensive activities of Remikiren.
DB00295
Morphine may increase the hypotensive activities of Remikiren.
DB00296
Ropivacaine may increase the hypotensive activities of Remikiren.
DB00297
Bupivacaine may increase the hypotensive activities of Remikiren.
DB00323
Tolcapone may increase the hypotensive activities of Remikiren.
DB00334
Olanzapine may increase the hypotensive activities of Remikiren.
DB00384
Triamterene may increase the hypotensive activities of Remikiren.
DB00413
Pramipexole may increase the hypotensive activities of Remikiren.
DB00421
Spironolactone may increase the hypotensive activities of Remikiren.
DB00435
Nitric Oxide may increase the hypotensive activities of Remikiren.
DB00486
Nabilone may increase the hypotensive activities of Remikiren.
DB00489
Sotalol may increase the hypotensive activities of Remikiren.
DB00594
Amiloride may increase the hypotensive activities of Remikiren.
DB00599
Thiopental may increase the hypotensive activities of Remikiren.
DB00631
Clofarabine may increase the hypotensive activities of Remikiren.
DB00661
Verapamil may increase the hypotensive activities of Remikiren.
DB00681
Amphotericin B may increase the hypotensive activities of Remikiren.
DB00697
Tizanidine may increase the hypotensive activities of Remikiren.
DB00703
Methazolamide may increase the hypotensive activities of Remikiren.
DB00706
Tamsulosin may increase the hypotensive activities of Remikiren.
DB00714
Apomorphine may increase the hypotensive activities of Remikiren.
DB00742
Mannitol may increase the hypotensive activities of Remikiren.
DB00755
Tretinoin may increase the hypotensive activities of Remikiren.
DB00872
Conivaptan may increase the hypotensive activities of Remikiren.
DB00883
Isosorbide dinitrate may increase the hypotensive activities of Remikiren.
DB00887
Bumetanide may increase the hypotensive activities of Remikiren.
DB00903
Etacrynic acid may increase the hypotensive activities of Remikiren.
DB00922
Levosimendan may increase the hypotensive activities of Remikiren.
DB01002
Levobupivacaine may increase the hypotensive activities of Remikiren.
DB01020
Isosorbide mononitrate may increase the hypotensive activities of Remikiren.
DB01041
Thalidomide may increase the hypotensive activities of Remikiren.
DB01113
Papaverine may increase the hypotensive activities of Remikiren.
DB01115
Nifedipine may increase the hypotensive activities of Remikiren.
DB01118
Amiodarone may increase the hypotensive activities of Remikiren.
DB01144
Diclofenamide may increase the hypotensive activities of Remikiren.
DB01169
Arsenic trioxide may increase the hypotensive activities of Remikiren.
DB01229
Paclitaxel may increase the hypotensive activities of Remikiren.
DB01235
Levodopa may increase the hypotensive activities of Remikiren.
DB01282
Carbetocin may increase the hypotensive activities of Remikiren.
DB01612
Amyl Nitrite may increase the hypotensive activities of Remikiren.
DB04899
Nesiritide may increase the hypotensive activities of Remikiren.
DB04920
Clevidipine may increase the hypotensive activities of Remikiren.
DB06292
Dapagliflozin may increase the hypotensive activities of Remikiren.
DB08907
Canagliflozin may increase the hypotensive activities of Remikiren.
DB09038
Empagliflozin may increase the hypotensive activities of Remikiren.
DB09077
Dinutuximab may increase the hypotensive activities of Remikiren.
DB09112
Nitrous acid may increase the hypotensive activities of Remikiren.
DB09204
Arotinolol may increase the hypotensive activities of Remikiren.
DB09232
Cilnidipine may increase the hypotensive activities of Remikiren.
DB09286
Pipamperone may increase the hypotensive activities of Remikiren.
DB09292
Sacubitril may increase the hypotensive activities of Remikiren.
DB01238
The risk or severity of hypotension can be increased when Aripiprazole is combined with Remikiren.
DB14185
The risk or severity of hypotension can be increased when Aripiprazole lauroxil is combined with Remikiren.
DB00575
The risk or severity of hypotension can be increased when Clonidine is combined with Remikiren.
DB01224
Quetiapine may increase the hypotensive activities of Remikiren.
DB00246
Ziprasidone may increase the antihypertensive activities of Remikiren.
DB00606
The therapeutic efficacy of Cyclothiazide can be increased when used in combination with Remikiren.
DB01021
The therapeutic efficacy of Trichlormethiazide can be increased when used in combination with Remikiren.
DB01324
The therapeutic efficacy of Polythiazide can be increased when used in combination with Remikiren.
DB13532
The therapeutic efficacy of Cyclopenthiazide can be increased when used in combination with Remikiren.
DB00232
The therapeutic efficacy of Remikiren can be increased when used in combination with Methyclothiazide.
DB00436
The therapeutic efficacy of Remikiren can be increased when used in combination with Bendroflumethiazide.
DB00774
The therapeutic efficacy of Remikiren can be increased when used in combination with Hydroflumethiazide.
DB00880
The therapeutic efficacy of Remikiren can be increased when used in combination with Chlorothiazide.
DB00999
The therapeutic efficacy of Remikiren can be increased when used in combination with Hydrochlorothiazide.
DB00562
The therapeutic efficacy of Remikiren can be increased when used in combination with Benzthiazide.
DB13430
The therapeutic efficacy of Remikiren can be increased when used in combination with Mebutizide.
DB00808
The therapeutic efficacy of Remikiren can be increased when used in combination with Indapamide.

序列

实验性质

logP
3.9

caco2 Permeability
-6.13
ADME Research, USCD

外部标识符

resource：PubChem Compound
identifier：6324659
resource：PubChem Substance
identifier：46507286
resource：KEGG Compound
identifier：C07465
resource：ChemSpider
identifier：4884377
resource：BindingDB
identifier：50077669
resource：PharmGKB
identifier：PA164774779
resource：PDB
identifier：REM
resource：Therapeutic Targets Database
identifier：DAP001220
resource：Wikipedia
identifier：Remikiren
resource：ChEMBL
identifier：CHEMBL31601
resource：ZINC
identifier：ZINC000004217406

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id:BE0000270
name:Renin
organism:Humans
action:inhibitor
van Paassen P, Navis GJ, De Jong PE, De Zeeuw D: Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension. Eur J Clin Invest. 1999 Dec;29(12):1019-26.
MacFadyen RJ, Jones CR, Doig JK, Birnbock H, Reid JL: Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans. J Cardiovasc Pharmacol. 1995 Mar;25(3):347-53.
Kiowski W, Beermann J, Rickenbacher P, Haemmerli R, Thomas M, Burkart F, Meinertz T: Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition. Circulation. 1994 Dec;90(6):2748-56.
Hilgers KF, Fischli W, Veelken R, Mann JF: Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren. Hypertension. 1994 Jun;23(6 Pt 2):861-4.
Clozel JP, Fischli W: Comparative effects of three different potent renin inhibitors in primates. Hypertension. 1993 Jul;22(1):9-17.
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
known-action:yes
name:Renin
general-function:Receptor binding
specific-function:Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
gene-name:REN
locus:1q32
cellular-location:Secreted
transmembrane-regions:
signal-regions:1-23
theoretical-pi:7.07
molecular-weight:45057.125
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:9958GenAtlasRENGenBank Gene DatabaseL00073GenBank Protein Database190994Guide to Pharmacology2413UniProtKBP00797UniProt AccessionRENI_HUMAN
synonyms:3.4.23.15Angiotensinogenase
amino-acid-sequence:>lcl|BSEQ0000539|Renin MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
gene-sequence:>lcl|BSEQ0018936|Renin (REN) ATGGATGGATGGAGAAGGATGCCTCGCTGGGGACTGCTGCTGCTGCTCTGGGGCTCCTGT ACCTTTGGTCTCCCGACAGACACCACCACCTTTAAACGGATCTTCCTCAAGAGAATGCCC TCAATCCGAGAAAGCCTGAAGGAACGAGGTGTGGACATGGCCAGGCTTGGTCCCGAGTGG AGCCAACCCATGAAGAGGCTGACACTTGGCAACACCACCTCCTCCGTGATCCTCACCAAC TACATGGACACCCAGTACTATGGCGAGATTGGCATCGGCACCCCACCCCAGACCTTCAAA GTCGTCTTTGACACTGGTTCGTCCAATGTTTGGGTGCCCTCCTCCAAGTGCAGCCGTCTC TACACTGCCTGTGTGTATCACAAGCTCTTCGATGCTTCGGATTCCTCCAGCTACAAGCAC AATGGAACAGAACTCACCCTCCGCTATTCAACAGGGACAGTCAGTGGCTTTCTCAGCCAG GACATCATCACCGTGGGTGGAATCACGGTGACACAGATGTTTGGAGAGGTCACGGAGATG CCCGCCTTACCCTTCATGCTGGCCGAGTTTGATGGGGTTGTGGGCATGGGCTTCATTGAA CAGGCCATTGGCAGGGTCACCCCTATCTTCGACAACATCATCTCCCAAGGGGTGCTAAAA GAGGACGTCTTCTCTTTCTACTACAACAGAGATTCCGAGAATTCCCAATCGCTGGGAGGA CAGATTGTGCTGGGAGGCAGCGACCCCCAGCATTACGAAGGGAATTTCCACTATATCAAC CTCATCAAGACTGGTGTCTGGCAGATTCAAATGAAGGGGGTGTCTGTGGGGTCATCCACC TTGCTCTGTGAAGACGGCTGCCTGGCATTGGTAGACACCGGTGCATCCTACATCTCAGGT TCTACCAGCTCCATAGAGAAGCTCATGGAGGCCTTGGGAGCCAAGAAGAGGCTGTTTGAT TATGTCGTGAAGTGTAACGAGGGCCCTACACTCCCCGACATCTCTTTCCACCTGGGAGGC AAAGAATACACGCTCACCAGCGCGGACTATGTATTTCAGGAATCCTACAGTAGTAAAAAG CTGTGCACACTGGCCATCCACGCCATGGATATCCCGCCACCCACTGGACCCACCTGGGCC CTGGGGGCCACCTTCATCCGAAAGTTCTACACAGAGTTTGATCGGCGTAACAACCGCATT GGCTTCGCCTTGGCCCGCTGA
pfams:PF07966A1_PropeptidePF00026Asp
go-classifiers:componentextracellular regioncomponentextracellular spacecomponentlysosomecomponentplasma membranefunctionaspartic-type endopeptidase activityfunctionpeptidase activityfunctionreceptor bindingprocessangiotensin maturationprocessbeta-amyloid metabolic processprocesscell maturationprocesscellular protein metabolic processprocesscellular response to drugprocessdrinking behaviorprocesshormone-mediated signaling pathwayprocesskidney developmentprocessmale gonad developmentprocessmesonephros developmentprocessproteolysisprocessregulation of blood pressureprocessregulation of MAPK cascadeprocessrenin-angiotensin regulation of aldosterone productionprocessresponse to cAMPprocessresponse to cGMPprocessresponse to immobilization stressprocessresponse to lipopolysaccharide

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