ID

DB00226|APRD01006||

名称

Guanadrel

描述

Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent.

cas号

40580-59-4

唯一标识码

765C9332T4

状态

solid

组

approved,

指示

Used to treat and control hypertension.

药效学

High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanadrel works by controlling nerve impulses along certain nerve pathways. As a result, it relaxes the blood vessels so that blood passes through them more easily. This helps to lower blood pressure.

作用机制

Guanadrel is an adrenergic neuron inhibitor that slowly displaces norepinephrine from its storage in nerve endings. It blocks the release of norepinephrine in response to the sympathetic nerve stimulation, leading to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position.

毒性

Side effects include dizziness, drowsiness, headache, constipation, diarrhea, gas pains, loss of appetite, fatigue, and nasal congestion.

代谢

Primarily hepatic

吸收

Rapidly and readily absorbed from the gastrointestinal tract.

半衰期

10 hours

分类

description:This compound belongs to the class of organic compounds known as ketals. These are acetals derived from ketones by replacement of the oxo group by two hydrocarbyloxy groups R2C(OR)2 ( R not Hydrogen ). This term, once abandoned, has been reinstated as a subclass of acetals.
direct-parent:Ketals
kingdom:Organic compounds
superclass:Organic oxygen compounds
class:Organooxygen compounds
subclass:Ethers
alternative-parent:1,3-dioxolanes
alternative-parent:Carboximidamides
alternative-parent:Guanidines
alternative-parent:Hydrocarbon derivatives
alternative-parent:Imines
alternative-parent:Organopnictogen compounds
alternative-parent:Oxacyclic compounds
substituent:Aliphatic heteropolycyclic compound
substituent:Carboximidamide
substituent:Guanidine
substituent:Hydrocarbon derivative
substituent:Imine
substituent:Ketal
substituent:Meta-dioxolane
substituent:Organic nitrogen compound
substituent:Organoheterocyclic compound
substituent:Organonitrogen compound
substituent:Organopnictogen compound
substituent:Oxacycle

消除途径

种类

Adrenergic Antagonists
D018674
Amidines
D000578
Antihypertensive Agents
D000959
Cardiovascular Agents
D002317

盐类

DBSALT000889Guanadrel sulfateMT147RMO9122195-34-2RTEVGQJRTFFMLL-UHFFFAOYSA-N524.63524.262833446

蛋白质结合

Low, approximately 20%

清除

同义词

language:english/spanish/french; code:inn; name;Guanadrel
language:latin; code:inn; name;Guanadrelum

国际品牌

AnarelCutterHylorelPennwalt

配送量

产品

混合物

包装者

name:Pharmaceutical Utilization Management Program VA Inc.
url:

生产者

generic:否; url:; name;Pharmacia and upjohn co

价格

受影响的生物体

Humans and other mammals

剂量

atc代码

fda标签

化学品安全技术说明书

专利

食物相互作用

药物相互作用

DB00346
Alfuzosin may increase the hypotensive activities of Guanadrel.
DB01143
Guanadrel may increase the hypotensive activities of Amifostine.
DB01119
Diazoxide may increase the hypotensive activities of Guanadrel.
DB00422
Methylphenidate may decrease the antihypertensive activities of Guanadrel.
DB06701
Dexmethylphenidate may decrease the antihypertensive activities of Guanadrel.
DB08935
Guanadrel may increase the hypotensive activities of Obinutuzumab.
DB00806
Pentoxifylline may increase the hypotensive activities of Guanadrel.
DB00073
Guanadrel may increase the hypotensive activities of Rituximab.
DB00035
Desmopressin may decrease the antihypertensive activities of Guanadrel.
DB00091
Cyclosporine may decrease the antihypertensive activities of Guanadrel.
DB00216
Eletriptan may decrease the antihypertensive activities of Guanadrel.
DB00247
Methysergide may decrease the antihypertensive activities of Guanadrel.
DB00248
Cabergoline may decrease the antihypertensive activities of Guanadrel.
DB00289
Atomoxetine may decrease the antihypertensive activities of Guanadrel.
DB00315
Zolmitriptan may decrease the antihypertensive activities of Guanadrel.
DB00320
Dihydroergotamine may decrease the antihypertensive activities of Guanadrel.
DB00321
Amitriptyline may decrease the antihypertensive activities of Guanadrel.
DB00344
Protriptyline may decrease the antihypertensive activities of Guanadrel.
DB00353
Methylergometrine may decrease the antihypertensive activities of Guanadrel.
DB00370
Mirtazapine may decrease the antihypertensive activities of Guanadrel.
DB00420
Promazine may decrease the antihypertensive activities of Guanadrel.
DB00450
Droperidol may decrease the antihypertensive activities of Guanadrel.
DB00490
Buspirone may decrease the antihypertensive activities of Guanadrel.
DB00540
Nortriptyline may decrease the antihypertensive activities of Guanadrel.
DB00543
Amoxapine may decrease the antihypertensive activities of Guanadrel.
DB00561
Doxapram may decrease the antihypertensive activities of Guanadrel.
DB00572
Atropine may decrease the antihypertensive activities of Guanadrel.
DB00589
Lisuride may decrease the antihypertensive activities of Guanadrel.
DB00656
Trazodone may decrease the antihypertensive activities of Guanadrel.
DB00669
Sumatriptan may decrease the antihypertensive activities of Guanadrel.
DB00696
Ergotamine may decrease the antihypertensive activities of Guanadrel.
DB00699
Nicergoline may decrease the antihypertensive activities of Guanadrel.
DB00726
Trimipramine may decrease the antihypertensive activities of Guanadrel.
DB00734
Risperidone may decrease the antihypertensive activities of Guanadrel.
DB00777
Propiomazine may decrease the antihypertensive activities of Guanadrel.
DB00802
Alfentanil may decrease the antihypertensive activities of Guanadrel.
DB00813
Fentanyl may decrease the antihypertensive activities of Guanadrel.
DB00830
Phenmetrazine may decrease the antihypertensive activities of Guanadrel.
DB00831
Trifluoperazine may decrease the antihypertensive activities of Guanadrel.
DB00875
Flupentixol may decrease the antihypertensive activities of Guanadrel.
DB00908
Quinidine may decrease the antihypertensive activities of Guanadrel.
DB00918
Almotriptan may decrease the antihypertensive activities of Guanadrel.
DB00952
Naratriptan may decrease the antihypertensive activities of Guanadrel.
DB00953
Rizatriptan may decrease the antihypertensive activities of Guanadrel.
DB00988
Dopamine may decrease the antihypertensive activities of Guanadrel.
DB00998
Frovatriptan may decrease the antihypertensive activities of Guanadrel.
DB01028
Methoxyflurane may decrease the antihypertensive activities of Guanadrel.
DB01049
Ergoloid mesylate may decrease the antihypertensive activities of Guanadrel.
DB01126
Dutasteride may decrease the antihypertensive activities of Guanadrel.
DB01142
Doxepin may decrease the antihypertensive activities of Guanadrel.
DB01149
Nefazodone may decrease the antihypertensive activities of Guanadrel.
DB01151
Desipramine may decrease the antihypertensive activities of Guanadrel.
DB01182
Propafenone may decrease the antihypertensive activities of Guanadrel.
DB01216
Finasteride may decrease the antihypertensive activities of Guanadrel.
DB01267
Paliperidone may decrease the antihypertensive activities of Guanadrel.
DB01392
Yohimbine may decrease the antihypertensive activities of Guanadrel.
DB01403
Methotrimeprazine may decrease the antihypertensive activities of Guanadrel.
DB01591
Solifenacin may decrease the antihypertensive activities of Guanadrel.
DB01608
Periciazine may decrease the antihypertensive activities of Guanadrel.
DB01614
Acepromazine may decrease the antihypertensive activities of Guanadrel.
DB01622
Thioproperazine may decrease the antihypertensive activities of Guanadrel.
DB01624
Zuclopenthixol may decrease the antihypertensive activities of Guanadrel.
DB02032
Epicaptopril may decrease the antihypertensive activities of Guanadrel.
DB04581
1-benzylimidazole may decrease the antihypertensive activities of Guanadrel.
DB04829
Lysergic acid diethylamide may decrease the antihypertensive activities of Guanadrel.
DB04836
Amineptine may decrease the antihypertensive activities of Guanadrel.
DB04855
Dronedarone may decrease the antihypertensive activities of Guanadrel.
DB04908
Flibanserin may decrease the antihypertensive activities of Guanadrel.
DB04946
Iloperidone may decrease the antihypertensive activities of Guanadrel.
DB05562
Naluzotan may decrease the antihypertensive activities of Guanadrel.
DB06016
Cariprazine may decrease the antihypertensive activities of Guanadrel.
DB06148
Mianserin may decrease the antihypertensive activities of Guanadrel.
DB06153
Pizotifen may decrease the antihypertensive activities of Guanadrel.
DB06216
Asenapine may decrease the antihypertensive activities of Guanadrel.
DB06678
Esmirtazapine may decrease the antihypertensive activities of Guanadrel.
DB06684
Vilazodone may decrease the antihypertensive activities of Guanadrel.
DB06690
Nitrous oxide may decrease the antihypertensive activities of Guanadrel.
DB06763
Saralasin may decrease the antihypertensive activities of Guanadrel.
DB08810
Cinitapride may decrease the antihypertensive activities of Guanadrel.
DB08815
Lurasidone may decrease the antihypertensive activities of Guanadrel.
DB08841
Tyramine may decrease the antihypertensive activities of Guanadrel.
DB08954
Ifenprodil may decrease the antihypertensive activities of Guanadrel.
DB08996
Dimetacrine may decrease the antihypertensive activities of Guanadrel.
DB09016
Butriptyline may decrease the antihypertensive activities of Guanadrel.
DB09061
Cannabidiol may decrease the antihypertensive activities of Guanadrel.
DB09068
Vortioxetine may decrease the antihypertensive activities of Guanadrel.
DB09128
Brexpiprazole may decrease the antihypertensive activities of Guanadrel.
DB09167
Dosulepin may decrease the antihypertensive activities of Guanadrel.
DB09205
Moxisylyte may decrease the antihypertensive activities of Guanadrel.
DB09289
Tianeptine may decrease the antihypertensive activities of Guanadrel.
DB09307
Oxaprotiline may decrease the antihypertensive activities of Guanadrel.
DB11273
Dihydroergocornine may decrease the antihypertensive activities of Guanadrel.
DB11481
Atipamezole may decrease the antihypertensive activities of Guanadrel.
DB11755
Tetrahydrocannabivarin may decrease the antihypertensive activities of Guanadrel.
DB12278
Propiverine may decrease the antihypertensive activities of Guanadrel.
DB12361
Piclozotan may decrease the antihypertensive activities of Guanadrel.
DB12371
Siponimod may decrease the antihypertensive activities of Guanadrel.
DB12551
Idazoxan may decrease the antihypertensive activities of Guanadrel.
DB12927
Theodrenaline may decrease the antihypertensive activities of Guanadrel.
DB12930
Opipramol may decrease the antihypertensive activities of Guanadrel.
DB13064
Tramazoline may decrease the antihypertensive activities of Guanadrel.
DB13114
Amitriptylinoxide may decrease the antihypertensive activities of Guanadrel.
DB13225
Dibenzepin may decrease the antihypertensive activities of Guanadrel.
DB13246
Quinupramine may decrease the antihypertensive activities of Guanadrel.
DB13323
Trichloroethylene may decrease the antihypertensive activities of Guanadrel.
DB13341
Fenozolone may decrease the antihypertensive activities of Guanadrel.
DB13345
Dihydroergocristine may decrease the antihypertensive activities of Guanadrel.
DB13384
Melitracen may decrease the antihypertensive activities of Guanadrel.
DB13385
Dihydroergocryptine may decrease the antihypertensive activities of Guanadrel.
DB13399
Terguride may decrease the antihypertensive activities of Guanadrel.
DB13411
Lofepramine may decrease the antihypertensive activities of Guanadrel.
DB13453
Xenon may decrease the antihypertensive activities of Guanadrel.
DB13496
Iprindole may decrease the antihypertensive activities of Guanadrel.
DB13510
Buflomedil may decrease the antihypertensive activities of Guanadrel.
DB13520
Metergoline may decrease the antihypertensive activities of Guanadrel.
DB13598
Diethyl ether may decrease the antihypertensive activities of Guanadrel.
DB13782
Imipramine oxide may decrease the antihypertensive activities of Guanadrel.
DB13852
Mefenorex may decrease the antihypertensive activities of Guanadrel.
DB13917
Deoxyepinephrine may decrease the antihypertensive activities of Guanadrel.
DB14010
5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Guanadrel.
DB14231
Quinoline Yellow WS may decrease the antihypertensive activities of Guanadrel.
DB14754
Solriamfetol may decrease the antihypertensive activities of Guanadrel.
DB00363
Clozapine may decrease the antihypertensive activities of Guanadrel.
DB00458
Imipramine may decrease the antihypertensive activities of Guanadrel.
DB00477
Chlorpromazine may decrease the antihypertensive activities of Guanadrel.
DB00633
Dexmedetomidine may decrease the antihypertensive activities of Guanadrel.
DB00679
Thioridazine may decrease the antihypertensive activities of Guanadrel.
DB00692
Phentolamine may decrease the antihypertensive activities of Guanadrel.
DB00708
Sufentanil may decrease the antihypertensive activities of Guanadrel.
DB00753
Isoflurane may decrease the antihypertensive activities of Guanadrel.
DB00797
Tolazoline may decrease the antihypertensive activities of Guanadrel.
DB00818
Propofol may decrease the antihypertensive activities of Guanadrel.
DB00899
Remifentanil may decrease the antihypertensive activities of Guanadrel.
DB00925
Phenoxybenzamine may decrease the antihypertensive activities of Guanadrel.
DB01018
Guanfacine may decrease the antihypertensive activities of Guanadrel.
DB01159
Halothane may decrease the antihypertensive activities of Guanadrel.
DB01189
Desflurane may decrease the antihypertensive activities of Guanadrel.
DB01200
Bromocriptine may decrease the antihypertensive activities of Guanadrel.
DB01236
Sevoflurane may decrease the antihypertensive activities of Guanadrel.
DB01242
Clomipramine may decrease the antihypertensive activities of Guanadrel.
DB04948
Lofexidine may decrease the antihypertensive activities of Guanadrel.
DB05271
Rotigotine may decrease the antihypertensive activities of Guanadrel.
DB08941
Isoxsuprine may decrease the antihypertensive activities of Guanadrel.
DB08950
Indoramin may decrease the antihypertensive activities of Guanadrel.
DB09242
Moxonidine may decrease the antihypertensive activities of Guanadrel.
DB00945
Acetylsalicylic acid may decrease the antihypertensive activities of Guanadrel.
DB15685
Selpercatinib may decrease the antihypertensive activities of Guanadrel.
DB15965
Naxitamab may decrease the antihypertensive activities of Guanadrel.
DB09282
Molsidomine may increase the hypotensive activities of Guanadrel.
DB00212
Remikiren may increase the hypotensive activities of Guanadrel.
DB00217
Bethanidine may increase the hypotensive activities of Guanadrel.
DB00287
Guanadrel may increase the hypotensive activities of Travoprost.
DB00521
Guanadrel may increase the hypotensive activities of Carteolol.
DB00559
Guanadrel may increase the hypotensive activities of Bosentan.
DB00616
Guanadrel may increase the hypotensive activities of Candoxatril.
DB00629
Guanadrel may increase the hypotensive activities of Guanabenz.
DB00765
Guanadrel may increase the hypotensive activities of Metyrosine.
DB00785
Guanadrel may increase the hypotensive activities of Cryptenamine.
DB00866
Guanadrel may increase the hypotensive activities of Alprenolol.
DB00869
Guanadrel may increase the hypotensive activities of Dorzolamide.
DB00886
Guanadrel may increase the hypotensive activities of Omapatrilat.
DB00905
Guanadrel may increase the hypotensive activities of Bimatoprost.
DB01089
Guanadrel may increase the hypotensive activities of Deserpidine.
DB01090
Guanadrel may increase the hypotensive activities of Pentolinium.
DB01116
Guanadrel may increase the hypotensive activities of Trimethaphan.
DB01170
Guanadrel may increase the hypotensive activities of Guanethidine.
DB01180
Guanadrel may increase the hypotensive activities of Rescinnamine.
DB01214
Guanadrel may increase the hypotensive activities of Metipranolol.
DB01295
Guanadrel may increase the hypotensive activities of Bevantolol.
DB01297
Guanadrel may increase the hypotensive activities of Practolol.
DB01347
Guanadrel may increase the hypotensive activities of Saprisartan.
DB01348
Guanadrel may increase the hypotensive activities of Spirapril.
DB01388
Guanadrel may increase the hypotensive activities of Mibefradil.
DB03322
Guanadrel may increase the hypotensive activities of Dexpropranolol.
DB04831
Guanadrel may increase the hypotensive activities of Tienilic acid.
DB04840
Guanadrel may increase the hypotensive activities of Debrisoquine.
DB04846
Guanadrel may increase the hypotensive activities of Celiprolol.
DB06268
Guanadrel may increase the hypotensive activities of Sitaxentan.
DB06403
Guanadrel may increase the hypotensive activities of Ambrisentan.
DB06445
Guanadrel may increase the hypotensive activities of Diethylnorspermine.
DB06762
Guanadrel may increase the hypotensive activities of Pinacidil.
DB06826
Guanadrel may increase the hypotensive activities of Unoprostone.
DB07767
Guanadrel may increase the hypotensive activities of Ferulic acid.
DB08808
Guanadrel may increase the hypotensive activities of Bupranolol.
DB08836
Guanadrel may increase the hypotensive activities of Temocapril.
DB08932
Guanadrel may increase the hypotensive activities of Macitentan.
DB08952
Guanadrel may increase the hypotensive activities of Indenolol.
DB08960
Guanadrel may increase the hypotensive activities of Hexamethonium.
DB09206
Guanadrel may increase the hypotensive activities of Trimazosin.
DB09220
Guanadrel may increase the hypotensive activities of Nicorandil.
DB09238
Guanadrel may increase the hypotensive activities of Manidipine.
DB09239
Guanadrel may increase the hypotensive activities of Niguldipine.
DB09363
Guanadrel may increase the hypotensive activities of Rauwolfia serpentina root.
DB11362
Guanadrel may increase the hypotensive activities of Selexipag.
DB11720
Guanadrel may increase the hypotensive activities of Angiotensin 1-7.
DB11738
Guanadrel may increase the hypotensive activities of Rilmenidine.
DB11770
Guanadrel may increase the hypotensive activities of Talinolol.
DB12054
Guanadrel may increase the hypotensive activities of BQ-123.
DB12092
Guanadrel may increase the hypotensive activities of Naftopidil.
DB12093
Guanadrel may increase the hypotensive activities of Tetrahydropalmatine.
DB12212
Guanadrel may increase the hypotensive activities of Landiolol.
DB12465
Guanadrel may increase the hypotensive activities of Ketanserin.
DB12661
Guanadrel may increase the hypotensive activities of Urapidil.
DB12766
Guanadrel may increase the hypotensive activities of Cicletanine.
DB12945
Guanadrel may increase the hypotensive activities of Dihydralazine.
DB13166
Guanadrel may increase the hypotensive activities of Zofenopril.
DB13211
Guanadrel may increase the hypotensive activities of Guanoxan.
DB13312
Guanadrel may increase the hypotensive activities of Delapril.
DB13374
Guanadrel may increase the hypotensive activities of Vincamine.
DB13400
Guanadrel may increase the hypotensive activities of Linsidomine.
DB13410
Guanadrel may increase the hypotensive activities of Guanoxabenz.
DB13429
Guanadrel may increase the hypotensive activities of Tolonidine.
DB13435
Guanadrel may increase the hypotensive activities of Endralazine.
DB13443
Guanadrel may increase the hypotensive activities of Esatenolol.
DB13452
Guanadrel may increase the hypotensive activities of Cadralazine.
DB13508
Guanadrel may increase the hypotensive activities of Cloranolol.
DB13575
Guanadrel may increase the hypotensive activities of Bietaserpine.
DB13604
Guanadrel may increase the hypotensive activities of Guanazodine.
DB13631
Guanadrel may increase the hypotensive activities of Methoserpidine.
DB13757
Guanadrel may increase the hypotensive activities of Epanolol.
DB13779
Guanadrel may increase the hypotensive activities of Guanoclor.
DB13801
Guanadrel may increase the hypotensive activities of Muzolimine.
DB13803
Guanadrel may increase the hypotensive activities of Xipamide.
DB13919
Guanadrel may increase the hypotensive activities of Candesartan.
DB14068
Guanadrel may increase the hypotensive activities of Dexniguldipine.
DB14094
Guanadrel may increase the hypotensive activities of Tocopherylquinone.
DB14125
Guanadrel may increase the hypotensive activities of Benazeprilat.
DB14207
Guanadrel may increase the hypotensive activities of Fosinoprilat.
DB14208
Guanadrel may increase the hypotensive activities of Ramiprilat.
DB14213
Guanadrel may increase the hypotensive activities of Perindoprilat.
DB14217
Guanadrel may increase the hypotensive activities of Quinaprilat.
DB00177
Valsartan may increase the hypotensive activities of Guanadrel.
DB00178
Ramipril may increase the hypotensive activities of Guanadrel.
DB00187
Esmolol may increase the hypotensive activities of Guanadrel.
DB00195
Betaxolol may increase the hypotensive activities of Guanadrel.
DB00206
Reserpine may increase the hypotensive activities of Guanadrel.
DB00214
Torasemide may increase the hypotensive activities of Guanadrel.
DB00264
Metoprolol may increase the hypotensive activities of Guanadrel.
DB00270
Isradipine may increase the hypotensive activities of Guanadrel.
DB00275
Olmesartan may increase the hypotensive activities of Guanadrel.
DB00310
Chlorthalidone may increase the hypotensive activities of Guanadrel.
DB00325
Nitroprusside may increase the hypotensive activities of Guanadrel.
DB00335
Atenolol may increase the hypotensive activities of Guanadrel.
DB00343
Diltiazem may increase the hypotensive activities of Guanadrel.
DB00350
Minoxidil may increase the hypotensive activities of Guanadrel.
DB00373
Timolol may increase the hypotensive activities of Guanadrel.
DB00381
Amlodipine may increase the hypotensive activities of Guanadrel.
DB00393
Nimodipine may increase the hypotensive activities of Guanadrel.
DB00401
Nisoldipine may increase the hypotensive activities of Guanadrel.
DB00492
Fosinopril may increase the hypotensive activities of Guanadrel.
DB00519
Trandolapril may increase the hypotensive activities of Guanadrel.
DB00524
Metolazone may increase the hypotensive activities of Guanadrel.
DB00528
Lercanidipine may increase the hypotensive activities of Guanadrel.
DB00542
Benazepril may increase the hypotensive activities of Guanadrel.
DB00571
Propranolol may increase the hypotensive activities of Guanadrel.
DB00584
Enalapril may increase the hypotensive activities of Guanadrel.
DB00590
Doxazosin may increase the hypotensive activities of Guanadrel.
DB00598
Labetalol may increase the hypotensive activities of Guanadrel.
DB00612
Bisoprolol may increase the hypotensive activities of Guanadrel.
DB00622
Nicardipine may increase the hypotensive activities of Guanadrel.
DB00657
Mecamylamine may increase the hypotensive activities of Guanadrel.
DB00678
Losartan may increase the hypotensive activities of Guanadrel.
DB00691
Moexipril may increase the hypotensive activities of Guanadrel.
DB00695
Furosemide may increase the hypotensive activities of Guanadrel.
DB00700
Eplerenone may increase the hypotensive activities of Guanadrel.
DB00722
Lisinopril may increase the hypotensive activities of Guanadrel.
DB00727
Nitroglycerin may increase the hypotensive activities of Guanadrel.
DB00790
Perindopril may increase the hypotensive activities of Guanadrel.
DB00796
Candesartan cilexetil may increase the hypotensive activities of Guanadrel.
DB00800
Fenoldopam may increase the hypotensive activities of Guanadrel.
DB00876
Eprosartan may increase the hypotensive activities of Guanadrel.
DB00881
Quinapril may increase the hypotensive activities of Guanadrel.
DB00960
Pindolol may increase the hypotensive activities of Guanadrel.
DB00966
Telmisartan may increase the hypotensive activities of Guanadrel.
DB00968
Methyldopa may increase the hypotensive activities of Guanadrel.
DB01023
Felodipine may increase the hypotensive activities of Guanadrel.
DB01029
Irbesartan may increase the hypotensive activities of Guanadrel.
DB01054
Nitrendipine may increase the hypotensive activities of Guanadrel.
DB01136
Carvedilol may increase the hypotensive activities of Guanadrel.
DB01158
Bretylium may increase the hypotensive activities of Guanadrel.
DB01162
Terazosin may increase the hypotensive activities of Guanadrel.
DB01193
Acebutolol may increase the hypotensive activities of Guanadrel.
DB01197
Captopril may increase the hypotensive activities of Guanadrel.
DB01203
Nadolol may increase the hypotensive activities of Guanadrel.
DB01244
Bepridil may increase the hypotensive activities of Guanadrel.
DB01275
Hydralazine may increase the hypotensive activities of Guanadrel.
DB01340
Cilazapril may increase the hypotensive activities of Guanadrel.
DB01359
Penbutolol may increase the hypotensive activities of Guanadrel.
DB01580
Oxprenolol may increase the hypotensive activities of Guanadrel.
DB04861
Nebivolol may increase the hypotensive activities of Guanadrel.
DB06712
Nilvadipine may increase the hypotensive activities of Guanadrel.
DB08931
Riociguat may increase the hypotensive activities of Guanadrel.
DB09026
Aliskiren may increase the hypotensive activities of Guanadrel.
DB09235
Efonidipine may increase the hypotensive activities of Guanadrel.
DB09236
Lacidipine may increase the hypotensive activities of Guanadrel.
DB09477
Enalaprilat may increase the hypotensive activities of Guanadrel.
DB11783
Imidapril may increase the hypotensive activities of Guanadrel.
DB09237
Guanadrel may increase the hypotensive activities of Levamlodipine.
DB00484
Brimonidine may increase the antihypertensive activities of Guanadrel.
DB00203
Sildenafil may increase the antihypertensive activities of Guanadrel.
DB00235
Milrinone may increase the antihypertensive activities of Guanadrel.
DB00820
Tadalafil may increase the antihypertensive activities of Guanadrel.
DB00862
Vardenafil may increase the antihypertensive activities of Guanadrel.
DB00975
Dipyridamole may increase the antihypertensive activities of Guanadrel.
DB05266
Ibudilast may increase the antihypertensive activities of Guanadrel.
DB06237
Avanafil may increase the antihypertensive activities of Guanadrel.
DB06267
Udenafil may increase the antihypertensive activities of Guanadrel.
DB09273
Doxofylline may increase the antihypertensive activities of Guanadrel.
DB11792
Mirodenafil may increase the antihypertensive activities of Guanadrel.
DB12010
Fostamatinib may increase the antihypertensive activities of Guanadrel.
DB00374
Treprostinil may increase the hypotensive activities of Guanadrel.
DB01088
Iloprost may increase the hypotensive activities of Guanadrel.
DB01240
Epoprostenol may increase the hypotensive activities of Guanadrel.
DB00468
Quinine may increase the hypotensive activities of Guanadrel.
DB14337
Salvia miltiorrhiza root may increase the hypotensive activities of Guanadrel.
DB00601
Linezolid may increase the hypotensive activities of Guanadrel.
DB00614
Furazolidone may increase the hypotensive activities of Guanadrel.
DB00721
Procaine may increase the hypotensive activities of Guanadrel.
DB00752
Tranylcypromine may increase the hypotensive activities of Guanadrel.
DB00780
Phenelzine may increase the hypotensive activities of Guanadrel.
DB00805
Minaprine may increase the hypotensive activities of Guanadrel.
DB01037
Selegiline may increase the hypotensive activities of Guanadrel.
DB01168
Procarbazine may increase the hypotensive activities of Guanadrel.
DB01171
Moclobemide may increase the hypotensive activities of Guanadrel.
DB01247
Isocarboxazid may increase the hypotensive activities of Guanadrel.
DB01367
Rasagiline may increase the hypotensive activities of Guanadrel.
DB01626
Pargyline may increase the hypotensive activities of Guanadrel.
DB04017
Clorgiline may increase the hypotensive activities of Guanadrel.
DB04818
Iproniazid may increase the hypotensive activities of Guanadrel.
DB04820
Nialamide may increase the hypotensive activities of Guanadrel.
DB06654
Safinamide may increase the hypotensive activities of Guanadrel.
DB08550
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Guanadrel.
DB09241
Methylene blue may increase the hypotensive activities of Guanadrel.
DB09243
Hydracarbazine may increase the hypotensive activities of Guanadrel.
DB09244
Pirlindole may increase the hypotensive activities of Guanadrel.
DB09245
Toloxatone may increase the hypotensive activities of Guanadrel.
DB09246
Benmoxin may increase the hypotensive activities of Guanadrel.
DB09248
Mebanazine may increase the hypotensive activities of Guanadrel.
DB09249
Octamoxin may increase the hypotensive activities of Guanadrel.
DB09250
Pheniprazine may increase the hypotensive activities of Guanadrel.
DB09251
Phenoxypropazine may increase the hypotensive activities of Guanadrel.
DB09252
Pivhydrazine may increase the hypotensive activities of Guanadrel.
DB09253
Safrazine may increase the hypotensive activities of Guanadrel.
DB09254
Caroxazone may increase the hypotensive activities of Guanadrel.
DB13875
Harmaline may increase the hypotensive activities of Guanadrel.
DB13876
Brofaromine may increase the hypotensive activities of Guanadrel.
DB00159
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Icosapent.
DB00244
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Mesalazine.
DB00328
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Indomethacin.
DB00461
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Nabumetone.
DB00465
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Ketorolac.
DB00469
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tenoxicam.
DB00482
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Celecoxib.
DB00500
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tolmetin.
DB00533
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Rofecoxib.
DB00554
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Piroxicam.
DB00573
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Fenoprofen.
DB00580
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Valdecoxib.
DB00586
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Diclofenac.
DB00605
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Sulindac.
DB00712
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Flurbiprofen.
DB00749
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Etodolac.
DB00784
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Mefenamic acid.
DB00788
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Naproxen.
DB00795
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Sulfasalazine.
DB00812
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Phenylbutazone.
DB00814
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Meloxicam.
DB00821
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Carprofen.
DB00861
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Diflunisal.
DB00936
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Salicylic acid.
DB00939
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Meclofenamic acid.
DB00991
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Oxaprozin.
DB01009
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Ketoprofen.
DB01014
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Balsalazide.
DB01050
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Ibuprofen.
DB01250
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Olsalazine.
DB01283
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Lumiracoxib.
DB01397
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Magnesium salicylate.
DB01399
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Salsalate.
DB01401
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Choline magnesium trisalicylate.
DB01419
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Antrafenine.
DB01424
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Aminophenazone.
DB01435
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Antipyrine.
DB01600
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tiaprofenic acid.
DB01628
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Etoricoxib.
DB02224
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Taxifolin.
DB03585
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Oxyphenbutazone.
DB04725
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Licofelone.
DB04743
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Nimesulide.
DB04812
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Benoxaprofen.
DB04817
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Metamizole.
DB04828
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Zomepirac.
DB05095
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Cimicoxib.
DB06725
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Lornoxicam.
DB06736
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Aceclofenac.
DB06737
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Zaltoprofen.
DB07402
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Azapropazone.
DB08439
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Parecoxib.
DB08797
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Salicylamide.
DB08940
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Kebuzone.
DB08942
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Isoxicam.
DB08951
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Indoprofen.
DB08955
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Ibuproxam.
DB08976
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Floctafenine.
DB08981
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Fenbufen.
DB08984
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Etofenamate.
DB08991
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Epirizole.
DB09084
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Benzydamine.
DB09213
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Dexibuprofen.
DB09214
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Dexketoprofen.
DB09215
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Droxicam.
DB09216
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tolfenamic acid.
DB09217
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Firocoxib.
DB09218
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Clonixin.
DB09285
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Morniflumate.
DB09288
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Propacetamol.
DB09295
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Talniflumate.
DB11455
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Robenacoxib.
DB11466
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tepoxalin.
DB11518
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Flunixin.
DB12399
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Polmacoxib.
DB12445
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Nitroaspirin.
DB12545
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Indobufen.
DB12610
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Ebselen.
DB13001
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tinoridine.
DB13167
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Alclofenac.
DB13217
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Fentiazac.
DB13232
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Suxibuzone.
DB13286
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Bumadizone.
DB13314
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Alminoprofen.
DB13371
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Difenpiramide.
DB13407
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Nifenazone.
DB13432
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Lonazolac.
DB13481
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tenidap.
DB13524
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Propyphenazone.
DB13527
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Proglumetacin.
DB13538
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Guacetisal.
DB13544
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Ethenzamide.
DB13612
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Carbaspirin calcium.
DB13629
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Mofebutazone.
DB13649
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Proquazone.
DB13657
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Benorilate.
DB13722
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Pirprofen.
DB13783
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Acemetacin.
DB13860
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Imidazole salicylate.
DB14059
The therapeutic efficacy of Guanadrel can be decreased when used in combination with SC-236.
DB14060
The therapeutic efficacy of Guanadrel can be decreased when used in combination with NS-398.
DB14938
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Flurbiprofen axetil.
DB09212
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Loxoprofen.
DB09227
Guanadrel may increase the antihypertensive activities of Barnidipine.
DB00181
The risk or severity of adverse effects can be increased when Baclofen is combined with Guanadrel.
DB00697
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tizanidine.
DB00211
The therapeutic efficacy of Midodrine can be decreased when used in combination with Guanadrel.
DB00221
The therapeutic efficacy of Isoetharine can be decreased when used in combination with Guanadrel.
DB00292
The therapeutic efficacy of Etomidate can be decreased when used in combination with Guanadrel.
DB00368
The therapeutic efficacy of Norepinephrine can be decreased when used in combination with Guanadrel.
DB00388
The therapeutic efficacy of Phenylephrine can be decreased when used in combination with Guanadrel.
DB00397
The therapeutic efficacy of Phenylpropanolamine can be decreased when used in combination with Guanadrel.
DB00610
The therapeutic efficacy of Metaraminol can be decreased when used in combination with Guanadrel.
DB00668
The therapeutic efficacy of Epinephrine can be decreased when used in combination with Guanadrel.
DB00723
The therapeutic efficacy of Methoxamine can be decreased when used in combination with Guanadrel.
DB00816
The therapeutic efficacy of Orciprenaline can be decreased when used in combination with Guanadrel.
DB00841
The therapeutic efficacy of Dobutamine can be decreased when used in combination with Guanadrel.
DB00867
The therapeutic efficacy of Ritodrine can be decreased when used in combination with Guanadrel.
DB00871
The therapeutic efficacy of Terbutaline can be decreased when used in combination with Guanadrel.
DB00901
The therapeutic efficacy of Bitolterol can be decreased when used in combination with Guanadrel.
DB00935
The therapeutic efficacy of Oxymetazoline can be decreased when used in combination with Guanadrel.
DB00938
The therapeutic efficacy of Salmeterol can be decreased when used in combination with Guanadrel.
DB00983
The therapeutic efficacy of Formoterol can be decreased when used in combination with Guanadrel.
DB01001
The therapeutic efficacy of Salbutamol can be decreased when used in combination with Guanadrel.
DB01064
The therapeutic efficacy of Isoprenaline can be decreased when used in combination with Guanadrel.
DB01102
The therapeutic efficacy of Arbutamine can be decreased when used in combination with Guanadrel.
DB01186
The therapeutic efficacy of Pergolide can be decreased when used in combination with Guanadrel.
DB01253
The therapeutic efficacy of Ergometrine can be decreased when used in combination with Guanadrel.
DB01274
The therapeutic efficacy of Arformoterol can be decreased when used in combination with Guanadrel.
DB01288
The therapeutic efficacy of Fenoterol can be decreased when used in combination with Guanadrel.
DB01291
The therapeutic efficacy of Pirbuterol can be decreased when used in combination with Guanadrel.
DB01363
The therapeutic efficacy of Ephedra sinica root can be decreased when used in combination with Guanadrel.
DB01364
The therapeutic efficacy of Ephedrine can be decreased when used in combination with Guanadrel.
DB01366
The therapeutic efficacy of Procaterol can be decreased when used in combination with Guanadrel.
DB01407
The therapeutic efficacy of Clenbuterol can be decreased when used in combination with Guanadrel.
DB01408
The therapeutic efficacy of Bambuterol can be decreased when used in combination with Guanadrel.
DB01472
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Guanadrel.
DB01537
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Guanadrel.
DB01579
The therapeutic efficacy of Phendimetrazine can be decreased when used in combination with Guanadrel.
DB05039
The therapeutic efficacy of Indacaterol can be decreased when used in combination with Guanadrel.
DB05395
The therapeutic efficacy of Amibegron can be decreased when used in combination with Guanadrel.
DB06152
The therapeutic efficacy of Nylidrin can be decreased when used in combination with Guanadrel.
DB06190
The therapeutic efficacy of Solabegron can be decreased when used in combination with Guanadrel.
DB06262
The therapeutic efficacy of Droxidopa can be decreased when used in combination with Guanadrel.
DB06694
The therapeutic efficacy of Xylometazoline can be decreased when used in combination with Guanadrel.
DB06706
The therapeutic efficacy of Isometheptene can be decreased when used in combination with Guanadrel.
DB06707
The therapeutic efficacy of Levonordefrin can be decreased when used in combination with Guanadrel.
DB06711
The therapeutic efficacy of Naphazoline can be decreased when used in combination with Guanadrel.
DB06764
The therapeutic efficacy of Tetryzoline can be decreased when used in combination with Guanadrel.
DB06814
The therapeutic efficacy of Protokylol can be decreased when used in combination with Guanadrel.
DB08893
The therapeutic efficacy of Mirabegron can be decreased when used in combination with Guanadrel.
DB08925
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Guanadrel.
DB08957
The therapeutic efficacy of Hexoprenaline can be decreased when used in combination with Guanadrel.
DB08985
The therapeutic efficacy of Etilefrine can be decreased when used in combination with Guanadrel.
DB09080
The therapeutic efficacy of Olodaterol can be decreased when used in combination with Guanadrel.
DB09082
The therapeutic efficacy of Vilanterol can be decreased when used in combination with Guanadrel.
DB09202
The therapeutic efficacy of Cirazoline can be decreased when used in combination with Guanadrel.
DB09203
The therapeutic efficacy of Synephrine can be decreased when used in combination with Guanadrel.
DB11124
The therapeutic efficacy of Racepinephrine can be decreased when used in combination with Guanadrel.
DB11278
The therapeutic efficacy of DL-Methylephedrine can be decreased when used in combination with Guanadrel.
DB11373
The therapeutic efficacy of Amitraz can be decreased when used in combination with Guanadrel.
DB11428
The therapeutic efficacy of Medetomidine can be decreased when used in combination with Guanadrel.
DB11477
The therapeutic efficacy of Xylazine can be decreased when used in combination with Guanadrel.
DB11541
The therapeutic efficacy of Ractopamine can be decreased when used in combination with Guanadrel.
DB11543
The therapeutic efficacy of Romifidine can be decreased when used in combination with Guanadrel.
DB11556
The therapeutic efficacy of Detomidine can be decreased when used in combination with Guanadrel.
DB11587
The therapeutic efficacy of Etafedrine can be decreased when used in combination with Guanadrel.
DB11785
The therapeutic efficacy of Anisodamine can be decreased when used in combination with Guanadrel.
DB11871
The therapeutic efficacy of PF-00610355 can be decreased when used in combination with Guanadrel.
DB12100
The therapeutic efficacy of Abediterol can be decreased when used in combination with Guanadrel.
DB12248
The therapeutic efficacy of Tulobuterol can be decreased when used in combination with Guanadrel.
DB12313
The therapeutic efficacy of Dopexamine can be decreased when used in combination with Guanadrel.
DB12526
The therapeutic efficacy of Batefenterol can be decreased when used in combination with Guanadrel.
DB12779
The therapeutic efficacy of Higenamine can be decreased when used in combination with Guanadrel.
DB12846
The therapeutic efficacy of Reproterol can be decreased when used in combination with Guanadrel.
DB13139
The therapeutic efficacy of Levosalbutamol can be decreased when used in combination with Guanadrel.
DB13251
The therapeutic efficacy of Octopamine can be decreased when used in combination with Guanadrel.
DB13378
The therapeutic efficacy of Norfenefrine can be decreased when used in combination with Guanadrel.
DB13398
The therapeutic efficacy of Oxyfedrine can be decreased when used in combination with Guanadrel.
DB13559
The therapeutic efficacy of Rimiterol can be decreased when used in combination with Guanadrel.
DB13692
The therapeutic efficacy of Tretoquinol can be decreased when used in combination with Guanadrel.
DB13777
The therapeutic efficacy of Prenalterol can be decreased when used in combination with Guanadrel.
DB13781
The therapeutic efficacy of Xamoterol can be decreased when used in combination with Guanadrel.
DB14752
The therapeutic efficacy of Racephedrine can be decreased when used in combination with Guanadrel.
DB14547
The therapeutic efficacy of Chloride ion can be decreased when used in combination with Guanadrel.
DB00182
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Amphetamine.
DB00191
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Phentermine.
DB00852
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Pseudoephedrine.
DB00865
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Benzphetamine.
DB00937
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Diethylpropion.
DB01255
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Lisdexamfetamine.
DB01365
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Mephentermine.
DB01442
The therapeutic efficacy of Guanadrel can be decreased when used in combination with MMDA.
DB01454
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Midomafetamine.
DB01467
The therapeutic efficacy of Guanadrel can be decreased when used in combination with 2,5-Dimethoxy-4-ethylamphetamine.
DB01484
The therapeutic efficacy of Guanadrel can be decreased when used in combination with 4-Bromo-2,5-dimethoxyamphetamine.
DB01509
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Tenamfetamine.
DB01556
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Chlorphentermine.
DB01566
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Methylenedioxyethamphetamine.
DB01576
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Dextroamphetamine.
DB01577
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Metamfetamine.
DB09480
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Iofetamine I-123.
DB12080
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Ritobegron.
DB13108
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Mephedrone.
DB13624
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Methoxyphenamine.
DB13703
The therapeutic efficacy of Guanadrel can be decreased when used in combination with Gepefrine.
DB13940
The therapeutic efficacy of Guanadrel can be decreased when used in combination with 2,5-Dimethoxy-4-ethylthioamphetamine.
DB00190
The risk or severity of hypotension can be increased when Carbidopa is combined with Guanadrel.
DB00457
The risk or severity of hypotension can be increased when Prazosin is combined with Guanadrel.
DB00041
Aldesleukin may increase the hypotensive activities of Guanadrel.
DB00086
Streptokinase may increase the hypotensive activities of Guanadrel.
DB00268
Ropinirole may increase the hypotensive activities of Guanadrel.
DB00295
Morphine may increase the hypotensive activities of Guanadrel.
DB00296
Ropivacaine may increase the hypotensive activities of Guanadrel.
DB00297
Bupivacaine may increase the hypotensive activities of Guanadrel.
DB00323
Tolcapone may increase the hypotensive activities of Guanadrel.
DB00334
Olanzapine may increase the hypotensive activities of Guanadrel.
DB00384
Triamterene may increase the hypotensive activities of Guanadrel.
DB00413
Pramipexole may increase the hypotensive activities of Guanadrel.
DB00421
Spironolactone may increase the hypotensive activities of Guanadrel.
DB00435
Nitric Oxide may increase the hypotensive activities of Guanadrel.
DB00486
Nabilone may increase the hypotensive activities of Guanadrel.
DB00489
Sotalol may increase the hypotensive activities of Guanadrel.
DB00594
Amiloride may increase the hypotensive activities of Guanadrel.
DB00599
Thiopental may increase the hypotensive activities of Guanadrel.
DB00631
Clofarabine may increase the hypotensive activities of Guanadrel.
DB00661
Verapamil may increase the hypotensive activities of Guanadrel.
DB00681
Amphotericin B may increase the hypotensive activities of Guanadrel.
DB00703
Methazolamide may increase the hypotensive activities of Guanadrel.
DB00706
Tamsulosin may increase the hypotensive activities of Guanadrel.
DB00714
Apomorphine may increase the hypotensive activities of Guanadrel.
DB00742
Mannitol may increase the hypotensive activities of Guanadrel.
DB00755
Tretinoin may increase the hypotensive activities of Guanadrel.
DB00872
Conivaptan may increase the hypotensive activities of Guanadrel.
DB00883
Isosorbide dinitrate may increase the hypotensive activities of Guanadrel.
DB00887
Bumetanide may increase the hypotensive activities of Guanadrel.
DB00903
Etacrynic acid may increase the hypotensive activities of Guanadrel.
DB00922
Levosimendan may increase the hypotensive activities of Guanadrel.
DB01002
Levobupivacaine may increase the hypotensive activities of Guanadrel.
DB01020
Isosorbide mononitrate may increase the hypotensive activities of Guanadrel.
DB01041
Thalidomide may increase the hypotensive activities of Guanadrel.
DB01113
Papaverine may increase the hypotensive activities of Guanadrel.
DB01115
Nifedipine may increase the hypotensive activities of Guanadrel.
DB01118
Amiodarone may increase the hypotensive activities of Guanadrel.
DB01144
Diclofenamide may increase the hypotensive activities of Guanadrel.
DB01169
Arsenic trioxide may increase the hypotensive activities of Guanadrel.
DB01229
Paclitaxel may increase the hypotensive activities of Guanadrel.
DB01235
Levodopa may increase the hypotensive activities of Guanadrel.
DB01282
Carbetocin may increase the hypotensive activities of Guanadrel.
DB01612
Amyl Nitrite may increase the hypotensive activities of Guanadrel.
DB04899
Nesiritide may increase the hypotensive activities of Guanadrel.
DB04920
Clevidipine may increase the hypotensive activities of Guanadrel.
DB06292
Dapagliflozin may increase the hypotensive activities of Guanadrel.
DB08822
Azilsartan medoxomil may increase the hypotensive activities of Guanadrel.
DB08907
Canagliflozin may increase the hypotensive activities of Guanadrel.
DB09038
Empagliflozin may increase the hypotensive activities of Guanadrel.
DB09077
Dinutuximab may increase the hypotensive activities of Guanadrel.
DB09112
Nitrous acid may increase the hypotensive activities of Guanadrel.
DB09204
Arotinolol may increase the hypotensive activities of Guanadrel.
DB09232
Cilnidipine may increase the hypotensive activities of Guanadrel.
DB09279
Fimasartan may increase the hypotensive activities of Guanadrel.
DB09286
Pipamperone may increase the hypotensive activities of Guanadrel.
DB09292
Sacubitril may increase the hypotensive activities of Guanadrel.
DB01238
The risk or severity of hypotension can be increased when Aripiprazole is combined with Guanadrel.
DB14185
The risk or severity of hypotension can be increased when Aripiprazole lauroxil is combined with Guanadrel.
DB00575
The risk or severity of hypotension can be increased when Clonidine is combined with Guanadrel.
DB01224
Quetiapine may increase the hypotensive activities of Guanadrel.
DB00246
Ziprasidone may increase the antihypertensive activities of Guanadrel.
DB00606
The therapeutic efficacy of Cyclothiazide can be increased when used in combination with Guanadrel.
DB01021
The therapeutic efficacy of Trichlormethiazide can be increased when used in combination with Guanadrel.
DB01324
The therapeutic efficacy of Polythiazide can be increased when used in combination with Guanadrel.
DB13532
The therapeutic efficacy of Cyclopenthiazide can be increased when used in combination with Guanadrel.
DB00232
The therapeutic efficacy of Guanadrel can be increased when used in combination with Methyclothiazide.
DB00436
The therapeutic efficacy of Guanadrel can be increased when used in combination with Bendroflumethiazide.
DB00774
The therapeutic efficacy of Guanadrel can be increased when used in combination with Hydroflumethiazide.
DB00880
The therapeutic efficacy of Guanadrel can be increased when used in combination with Chlorothiazide.
DB00999
The therapeutic efficacy of Guanadrel can be increased when used in combination with Hydrochlorothiazide.
DB00562
The therapeutic efficacy of Guanadrel can be increased when used in combination with Benzthiazide.
DB13430
The therapeutic efficacy of Guanadrel can be increased when used in combination with Mebutizide.
DB00808
The therapeutic efficacy of Guanadrel can be increased when used in combination with Indapamide.

序列

实验性质

Melting Point
213.5-215
U.S. Patent 3,547,951.
logP
0.6

外部标识符

resource：ChEBI
identifier：5555
resource：PubChem Compound
identifier：38521
resource：PubChem Substance
identifier：46506457
resource：KEGG Compound
identifier：C07035
resource：KEGG Drug
identifier：D08029
resource：ChemSpider
identifier：35305
resource：PharmGKB
identifier：PA164745308
resource：Therapeutic Targets Database
identifier：DAP000059
resource：Wikipedia
identifier：Guanadrel
resource：ChEMBL
identifier：CHEMBL1037
resource：RxCUI
identifier：26296

外部链接

Drugs.com
http://www.drugs.com/mtm/guanadrel.html

路径

目标

id:BE0000486
name:Sodium-dependent noradrenaline transporter
organism:Humans
action:partial agonist
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Malinow SH: Comparison of guanadrel and guanethidine efficacy and side effects. Clin Ther. 1983;5(3):284-9.
Finnerty FA Jr, Brogden RN: Guanadrel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in hypertension. Drugs. 1985 Jul;30(1):22-31.
Palmer JD, Nugent CA: Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9.
known-action:yes
name:Sodium-dependent noradrenaline transporter
general-function:Norepinephrine:sodium symporter activity
specific-function:Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
gene-name:SLC6A2
locus:16q12.2
cellular-location:Membrane
transmembrane-regions:65-85 93-112 136-156 235-253 262-279 315-332 344-365 398-417 444-462 478-498 519-538 557-575
signal-regions:
theoretical-pi:7.53
molecular-weight:69331.42
chromosome-location:16
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:11048GenAtlasSLC6A2GenBank Gene DatabaseM65105GenBank Protein Database189258Guide to Pharmacology926UniProtKBP23975UniProt AccessionSC6A2_HUMAN
synonyms:NAT1NETNET1Norepinephrine transporterSLC6A5Solute carrier family 6 member 2
amino-acid-sequence:>lcl|BSEQ0000970|Sodium-dependent noradrenaline transporter MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL VAQRDIRQFQLQHWLAI
gene-sequence:>lcl|BSEQ0010343|Sodium-dependent noradrenaline transporter (SLC6A2) ATGCTTCTGGCGCGGATGAACCCGCAGGTGCAGCCCGAGAACAACGGGGCGGACACGGGT CCAGAGCAGCCCCTTCGGGCGCGCAAAACTGCGGAGCTGCTGGTGGTGAAGGAGCGCAAC GGCGTCCAGTGCCTGCTGGCGCCCCGCGACGGCGACGCGCAGCCCCGGGAGACCTGGGGC AAGAAGATCGACTTCCTGCTGTCCGTAGTCGGCTTCGCAGTGGACCTGGCCAACGTGTGG CGCTTCCCCTACCTCTGCTACAAGAACGGCGGCGGTGCCTTCTTGATCCCGTACACACTG TTCCTTATCATCGCGGGGATGCCCCTGTTCTACATGGAGCTGGCTCTGGGACAGTACAAC CGGGAGGGGGCTGCCACCGTTTGGAAAATCTGCCCATTCTTCAAAGGCGTTGGCTATGCT GTCATCCTGATCGCCCTGTACGTTGGCTTCTACTACAACGTCATCATCGCCTGGTCACTC TACTACCTCTTCTCCTCCTTCACCCTCAACCTGCCCTGGACCGACTGTGGCCACACCTGG AACAGCCCCAACTGTACCGACCCCAAGCTCCTCAATGGCTCCGTGCTTGGCAACCACACC AAGTACTCCAAGTACAAGTTCACGCCGGCAGCCGAGTTTTATGAGCGTGGTGTCCTGCAC CTTCACGAGAGCAGCGGGATTCATGACATCGGCCTGCCCCAGTGGCAGCTCTTGCTCTGT CTGATGGTCGTCGTCATCGTCTTGTATTTTAGCCTCTGGAAAGGGGTGAAGACATCAGGA AAGGTGGTGTGGATCACAGCCACGCTGCCTTACTTCGTGCTGTTCGTGCTCCTGGTCCAT GGCGTCACGCTGCCCGGAGCCTCCAATGGCATCAATGCCTACCTGCACATCGACTTCTAC CGCTTGAAAGAGGCCACGGTATGGATTGATGCCGCAACTCAGATATTTTTTTCCTTGGGG GCTGGATTTGGAGTATTGATTGCATTTGCCAGTTACAACAAATTTGACAACAACTGTTAC AGGGATGCCCTGCTGACCAGCAGCATCAACTGTATCACCAGCTTCGTCTCTGGGTTCGCC ATCTTCTCCATCCTTGGTTACATGGCCCATGAACACAAGGTCAACATTGAGGATGTGGCC ACAGAAGGAGCTGGCCTAGTGTTCATCCTGTATCCAGAGGCCATTTCTACCCTGTCTGGA TCTACATTCTGGGCTGTTGTGTTTTTCGTCATGCTCCTGGCGCTGGGCCTTGACAGCTCA ATGGGAGGCATGGAGGCTGTCATCACGGGCCTGGCAGATGACTTCCAGGTCCTGAAGCGA CACCGGAAACTCTTCACATTTGGCGTCACCTTCAGCACTTTCCTTCTCGCCCTGTTCTGC ATAACCAAGGGTGGAATTTACGTCTTGACCCTCCTGGACACCTTTGCTGCGGGCACCTCC ATCCTTTTTGCTGTCCTCATGGAAGCCATCGGAGTTTCCTGGTTTTATGGAGTGGACAGG TTCAGCAACGACATCCAGCAGATGATGGGGTTCAGGCCGGGTCTATACTGGAGACTGTGC TGGAAGTTCGTCAGTCCTGCCTTCCTCCTGTTCGTGGTTGTGGTCAGCATCATCAACTTC AAGCCACTCACCTACGACGACTACATCTTCCCGCCCTGGGCCAACTGGGTGGGGTGGGGC ATCGCCCTGTCCTCCATGGTCCTGGTGCCCATCTACGTCATCTATAAGTTCCTCAGCACG CAGGGCTCTCTTTGGGAGAGACTGGCCTATGGCATCACGCCAGAGAACGAGCACCACCTG GTGGCTCAGAGGGACATCAGACAGTTCCAGTTGCAACACTGGCTGGCCATCTGA
pfams:PF00209SNF
go-classifiers:componentintegral component of plasma membranecomponentmembranecomponentneuron projectioncomponentplasma membranefunctionmonoamine transmembrane transporter activityfunctionnorepinephrineprocessmonoamine transportprocessnorepinephrine transportprocessresponse to painprocesssynaptic transmissionprocesstransmembrane transportprocesstransport

酶

载体

运输工具

药物反应

效应

不良反应