ID
DB00231|APRD00676||
名称
Temazepam
描述
Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chemical synthesis of temazepam was established by 1965 [A175333], mainstream contemporary use of the medication did not occur until it's legitimate use as treatment for insomnia was accepted and approved later on. In particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to obtain the necessary rest required for medical recovery or scheduled maneuvers and operations [A175339]. Regardless, temazepam has become one of the most frequently prescribed medications internationally and sees millions of prescriptions every year. Unfortunately, however, given its frequent use and the inherent nature of its pharmacological effects, temazepam - like many other benzodiazepines - possesses a high potential for misuse and is genuinely capable of developing drug tolerance, physical dependence, and addiction in users.
cas号
846-50-4
唯一标识码
CHB1QD2QSS
状态
solid
一般参考文献
Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41.
Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines]. Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72.
Vozeh S: [Pharmacokinetic of benzodiazepines in old age]. Schweiz Med Wochenschr. 1981 Nov 21;111(47):1789-93.
Shats V, Kozacov S: [Falls in the geriatric department: responsibility of the care-giver and the hospital]. Harefuah. 1995 Jun 1;128(11):690-3, 743.
Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9.
Heel RC, Brogden RN, Speight TM, Avery GS: Temazepam: a review of its pharmacological properties and therapeutic efficacy as an hypnotic. Drugs. 1981 May;21(5):321-40. doi: 10.2165/00003495-198121050-00001.
Fraschini F, Stankov B: Temazepam: pharmacological profile of a benzodiazepine and new trends in its clinical application. Pharmacol Res. 1993 Feb-Mar;27(2):97-113. doi: 10.1006/phrs.1993.1011.
Ochs HR, Greenblatt DJ, Verburg-Ochs B, Matlis R: Temazepam clearance unaltered in cirrhosis. Am J Gastroenterol. 1986 Jan;81(1):80-4.
Maggini C, Murri M, Sacchetti G: Evaluation of the effectiveness of temazepam on the insomnia of patients with neurosis and endogenous depression. Arzneimittelforschung. 1969 Oct;19(10):1647-52.
Caldwell JA, Caldwell JL: Fatigue in military aviation: an overview of US military-approved pharmacological countermeasures. Aviat Space Environ Med. 2005 Jul;76(7 Suppl):C39-51.
English BA, Dortch M, Ereshefsky L, Jhee S: Clinically significant psychotropic drug-drug interactions in the primary care setting. Curr Psychiatry Rep. 2012 Aug;14(4):376-90. doi: 10.1007/s11920-012-0284-9.

Electronic Medicines Compendium: Temazepam 10mg Tablets Monograph
https://www.medicines.org.uk/emc/product/8792/smpc
Temazepam Capsules USP 15 mg and 30 mg Canadian Product Monograph
//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/718/original/00043056.PDF?1551292587
Temazepam Fact Sheet from http://cdn.neiglobal.com/content/pg/live/temazepam.pdf
//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/721/original/temazepam.pdf?1551292694
F3718Temazepam Capsules USP 15 mg and 30 mg Canadian Product Monograph//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/718/original/00043056.PDF?1551292587F3721Temazepam Fact Sheet from http://cdn.neiglobal.com/content/pg/live/temazepam.pdf//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/721/original/temazepam.pdf?1551292694
approved,investigational,
指示
Temazepam is specifically indicated only for the short-term management of insomnia [FDA Label], [L5539]. Furthermore, such management is generally predominantly associated with the symptomatic relief of transient and short-term insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings and/or early morning awakenings [F3718]. In particular, the official prescribing information for temazepam typically specifies that the instructions issued for dispensed prescriptions of the medication should indicate specifically that patients are only expected to use the therapy for short periods of time - usually 7-10 days in general [FDA Label, F3718]. Subsequently, treatment with temazepam should usually not exceed 7 to 10 consecutive days and nor should it be prescribed in quantities exceeding a one-month supply [F3718]. Some regional prescribing information also notes that temazepam may be used for premedication prior to minor surgery or other related procedures [L5539].
药效学
Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia [FDA Label] [A175207, A175210, L5539, F3718, F3721]. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS [A175207, A175210, F3718, F3721]. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors [A175207, A175210, F3718, F3721]. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. In sleep laboratory studies, the effect of temazepam was compared to placebo during a two week period [F3718]. The studies demonstrated a linear dose-response improvement in total sleep time and sleep latency with substantial drug-placebo differences apparent for total sleep time and for sleep latency at higher doses of temazepam [F3718]. Regardless, REM sleep was ultimately unchanged but slow wave sleep was decreased [F3718]. Moreover, a transient syndrome, known as "rebound insomnia", wherein the symptoms that led to treatment with temazepam in the first place recur in an enhanced form, may happen on withdrawal of temazepam treatment [F3718]. The possibility of this occurrence is in part why long term use of temazepam is not recommended due to worries over tolerance and dependence wherein patients' bodies become physiologically accustomed to the regular presence and pharmacological effect of higher and higher doses of the benzodiazepine used [F3718]. The duration of hypnotic effect and the profile of unwanted adverse effects may be influenced by the distribution and elimination half-lives of the administered temazepam and any active metabolites that may be formed [F3718]. When such half-lives are long, the drug or its metabolite(s) may accumulate during periods of nightly administration and be associated with impairments of cognitive and motor performance during waking hours [F3718]. Conversely, if half-lives are short, the drug and metabolites would be cleared before the next dose is ingested, and carry-over effects related to sedation or CNS depression should be minimal or not present at all [F3718]. However, during nightly use and for an extended period, pharmacodynamic tolerance or adaptation to some effects of benzodiazepine hypnotics may develop - which may also contribute to the possibility of 'rebound insomnia' [F3718]. Consequently, if the drug has a very short elimination half-life, it is possible that a relative deficiency (for example, in relation to benzodiazepine GABA(a) receptor sites) may occur at some point in the interval between each night's use [F3718]. This sequence of events may account for certain clinical findings reported happening after several weeks of nightly use of rapidly eliminated benzodiazepine hypnotics, including increased wakefulness during the last third of the night and the appearance of increased daytime anxiety [F3718].
作用机制
Gamma-Aminobutyric acid (GABA) is considered the principal inhibitory neurotransmitter in the human body [A175207, A175210, F3718, F3721]. When GABA binds to GABA(a) receptors found in neuron synapses, chloride ions are conducted across neuron cell membranes via an ion channel in the receptors [A175207, A175210, F3718, F3721]. With enough chloride ions conducted, the local, associated neuron membrane potentials are hyperpolarized - making it more difficult or less likely for action potentials to fire, ultimately resulting in less excitation of the neurons [A175207, A175210, F3718, F3721]. Subsequently, benzodiazepines like temazepam can bind to benzodiazepine receptors that are components of various varieties of GABA(a) receptors [A175207, A175210, F3718, F3721]. This binding acts to enhance the effects of GABA by increasing GABA affinity for the GABA(a) receptor, which ultimately enhances GABA ligand binding at the receptors [A175207, A175210, F3718, F3721]. This enhanced ligand binding of the inhibitory neurotransmitter GABA to the receptors increases the aforementioned chloride ion conduction (perhaps reportedly via an increase in the frequency of the chloride channel opening), resulting in a hyperpolarized cell membrane that prevents further excitation of the associated neuron cells [A175207, A175210, F3718, F3721]. Combined with the notion that such benzodiazepine receptor associated GABA(a) receptors exist both peripherally and in the CNS, this activity consequently facilitates various effects like sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721].
毒性
Manifestations of acute overdosage of temazepam, as with other benzodiazepines, can be expected to reflect the increasing CNS effects of the drug and include somnolence, confusion, and coma, with reduced or absent reflexes [FDA Label] [L5539, F3718, F3721]. With large overdoses, respiratory depression, hypotension, and finally coma can occur [FDA Label] [L5539, F3718, F3721]. Benzodiazepines like temazepam might cause fetal harm when administered to a pregnant woman. Transplacental distribution has in the past resulted in neonatal CNS depression following the ingestion of therapeutic doses of related benzodiazepine hypnotics like diazepam during the last weeks of pregnancy [FDA Label] [L5539, F3718, F3721]. It is not known whether this drug is excreted in human milk [FDA Label] [L5539, F3718, F3721]. Caution should, therefore, be exercised when temazepam is administered to a nursing woman [FDA Label] [L5539, F3718, F3721]. Safety and effectiveness in pediatric patients have not been established [FDA Label] [L5539, F3718, F3721]. Lower doses of temazepam, like 7.5 mg is recommended as the initial dosage for patients aged 65 and over since the risk of the development of oversedation, dizziness, confusion, ataxia and/or falls increases substantially with larger doses of benzodiazepines in elderly and debilitated patients [FDA Label] [L5539, F3718, F3721]. No evidence of carcinogenicity was observed in animal studies although hyperplastic liver nodules were observed in female mice exposed to the highest doses of temazepam [FDA Label] [L5539, F3718, F3721]. The clinical significance of this finding is not known [FDA Label] [L5539, F3718, F3721]. Fertility in male and female rats was not adversely affected by temazepam toxicity studies [FDA Label] [L5539, F3718, F3721]. No mutagenicity tests have been done with temazepam [FDA Label] [L5539, F3718, F3721].
代谢
First-pass metabolism of temazepam is minimal at approximately 5-8% of an administered dose [F3718, L5539]. Nevertheless, temazepam is principally metabolized in the liver where most of the unchanged drug is directly conjugated to glucuronide and excreted in the urine [F3718, L5539]. In particular, the primary metabolite present in the blood is the O-conjugate of temazepam [FDA Label, F3718, L5539]. Less than 5% of the drug is demethylated to oxazepam and subsequently eliminated as the glucuronide [F3718, L5539]. Regardless, the glucuronides of temazepam have no demonstrable CNS activity and it is believed that no active metabolites are formed in general [FDA Label, F3718, L5539]. Since temazepam mainly undergoes Phase II conjugation reactions, it is proposed that it is devoid of CYP450 interactions.[A38982]
吸收
Studies demonstrate that between 90 to 100% of an orally administered temazepam dose is absorbed, making the medication very well absorbed [F3718, L5539]. The oral administration of 15 to 45 mg temazepam resulted in rapid absorption with significant blood levels achieved in 30 minutes and peak levels at 2-3 hours [F3718, L5539]. In particular, direct studies following the oral ingestion of 30 mg of temazepam revealed measurable plasma concentrations were obtained 10-20 minutes after dosing with peak plasma levels ranging between 666-982 ng/mL (with a mean of 865 ng/mL) presenting approximately 1.2-1.6 hours (with a mean of 1.5 hours) after the dosing [FDA Label]. Finally, a dose-proportional relationship was established for the area under the plasma concentration/time curve over the 15 to 30 mg dose range [FDA Label].
半衰期
The terminal half-life determined for temazepam is recorded as being between 3.5-18 hours, with a mean of 9 hours [F3718, L5539].
分类
description:This compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
direct-parent:1,4-benzodiazepines
kingdom:Organic compounds
superclass:Organoheterocyclic compounds
class:Benzodiazepines
subclass:1,4-benzodiazepines
alternative-parent:Alkanolamines
alternative-parent:Alpha amino acids and derivatives
alternative-parent:Aryl chlorides
alternative-parent:Azacyclic compounds
alternative-parent:Benzene and substituted derivatives
alternative-parent:Carbonyl compounds
alternative-parent:Hydrocarbon derivatives
alternative-parent:Ketimines
alternative-parent:Lactams
alternative-parent:Organic oxides
alternative-parent:Organochlorides
alternative-parent:Organopnictogen compounds
alternative-parent:Propargyl-type 1,3-dipolar organic compounds
alternative-parent:Tertiary carboxylic acid amides
substituent:1,4-benzodiazepine
substituent:Alkanolamine
substituent:Alpha-amino acid or derivatives
substituent:Aromatic heteropolycyclic compound
substituent:Aryl chloride
substituent:Aryl halide
substituent:Azacycle
substituent:Benzenoid
substituent:Carbonyl group
substituent:Carboxamide group
substituent:Carboxylic acid derivative
substituent:Hydrocarbon derivative
substituent:Imine
substituent:Ketimine
substituent:Lactam
substituent:Monocyclic benzene moiety
substituent:Organic 1,3-dipolar compound
substituent:Organic nitrogen compound
substituent:Organic oxide
substituent:Organic oxygen compound
substituent:Organochloride
substituent:Organohalogen compound
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound
substituent:Propargyl-type 1,3-dipolar organic compound
substituent:Tertiary carboxylic acid amide
消除途径
Following a single dose, 80-90% of the dose appears in the urine, predominantly as the O-conjugate metabolite, and 3-13% of the dose appears in the faeces [FDA Label] [F3718, L5539]. Less than 2% of the dose is excreted unchanged or as N-desmethyltemazepam in the urine [FDA Label] [F3718, L5539].
种类
Anti-Anxiety Agents
D014151
Benzazepines
D001552
Benzodiazepine hypnotics and sedatives

Benzodiazepines and benzodiazepine derivatives
D001569
Central Nervous System Agents
D002491
Central Nervous System Depressants
D002492
Cytochrome P-450 CYP2B6 Substrates

Cytochrome P-450 CYP2C8 Substrates

Cytochrome P-450 CYP2C9 Substrates

Cytochrome P-450 CYP3A Substrates

Cytochrome P-450 CYP3A4 Substrates

Cytochrome P-450 Substrates

Drugs that are Mainly Renally Excreted

GABA Agents
D018682
GABA Modulators
D018757
Heterocyclic Compounds, Fused-Ring
D000072471
Hypnotics and Sedatives
D006993
Muscle Relaxants

Muscle Relaxants, Centrally Acting Agents
D009125
Psychotropic Drugs
D011619
Tranquilizing Agents
D014149
盐类
DBSALT002272Temazepam hydrochlorideIA4EP0700697598-16-8GPVUAFAZVYNKRQ-UHFFFAOYSA-N337.2336.0432331DBSALT002271Temazepam sulfateI1HX8463I031677-86-8XNBFXTXDZMWXMN-UHFFFAOYSA-N398.81398.0339351
蛋白质结合
It has been recorded that about 96% of unchanged temazepam is bound to plasma proteins [F3718, L5539].
清除
Studies regarding the clearance of temazepam have recorded the values of 1.03 ml/min/kg and 31 ml/min/kg for the clearance of total temazepam and the clearance of unbound temazepam, respectively [A175306].
同义词
language:english; code:inn/usan; name;Temazepam
国际品牌
EuhypnosNorkotralNormisonNortemRemestanTemazeTemtabs
配送量
The volume of distribution documented for temazepam is 1.3-1.5 L/kg body weight - and in particular, 43-68 L/kg for the unbound fraction [L5539].
产品
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ended-marketing-on:2019-10-11
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA070920
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:Liberty Pharmaceuticals, Inc.
ndc-id:
ndc-product-code:0440-8474
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2012-06-28
ended-marketing-on:2019-10-15
dosage-form:Capsule
strength:7.5 mg/1
route:Oral
fda-application-number:ANDA071457
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:Liberty Pharmaceuticals, Inc.
ndc-id:
ndc-product-code:0440-8475
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1987-04-21
ended-marketing-on:2019-10-15
dosage-form:Capsule
strength:15 mg/1
route:Oral
fda-application-number:ANDA071456
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:Liberty Pharmaceuticals, Inc.
ndc-id:
ndc-product-code:0440-8476
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1987-04-21
ended-marketing-on:2019-10-15
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA071457
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:Liberty Pharmaceuticals, Inc.
ndc-id:
ndc-product-code:0440-8477
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2012-06-28
ended-marketing-on:2019-10-15
dosage-form:Capsule
strength:22.5 mg/1
route:Oral
fda-application-number:ANDA071457
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:REMEDYREPACK INC.
ndc-id:
ndc-product-code:70518-6470
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2020-03-30
ended-marketing-on:2020-03-30
dosage-form:Capsule
strength:15 mg/1
route:Oral
fda-application-number:ANDA071456
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:McKesson Contract Packaging
ndc-id:
ndc-product-code:76237-250
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2011-12-06
ended-marketing-on:2017-09-30
dosage-form:Capsule
strength:15 mg/1
route:Oral
fda-application-number:ANDA071427
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:McKesson Contract Packaging
ndc-id:
ndc-product-code:76237-251
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1988-01-12
ended-marketing-on:2017-09-30
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA071428
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:Directrx
ndc-id:
ndc-product-code:61919-264
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2015-01-01
ended-marketing-on:
dosage-form:Capsule
strength:30 mg/1
route:Oral
fda-application-number:ANDA071457
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:AvKARE
ndc-id:
ndc-product-code:42291-797
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2015-08-25
ended-marketing-on:
dosage-form:Capsule
strength:7.5 mg/1
route:Oral
fda-application-number:ANDA078581
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:bryant ranch prepack
ndc-id:
ndc-product-code:63629-1054
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1987-04-21
ended-marketing-on:
dosage-form:Capsule
strength:15 mg/1
route:Oral
fda-application-number:ANDA071456
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Temazepam
labeller:Aa Pharma Inc
ndc-id:
ndc-product-code:
dpd-id:02225964
ema-product-code:
ema-ma-number:
started-marketing-on:1996-10-02
ended-marketing-on:
dosage-form:Capsule
strength:15 mg
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Temazepam
labeller:Aa Pharma Inc
ndc-id:
ndc-product-code:
dpd-id:02225972
ema-product-code:
ema-ma-number:
started-marketing-on:1996-10-02
ended-marketing-on:
dosage-form:Capsule
strength:30 mg
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Temazepam-15
labeller:Pro Doc Limitee
ndc-id:
ndc-product-code:
dpd-id:02229760
ema-product-code:
ema-ma-number:
started-marketing-on:1997-08-06
ended-marketing-on:2017-05-05
dosage-form:Capsule
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Temazepam-30
labeller:Pro Doc Limitee
ndc-id:
ndc-product-code:
dpd-id:02229761
ema-product-code:
ema-ma-number:
started-marketing-on:1997-08-06
ended-marketing-on:2017-05-05
dosage-form:Capsule
strength:
route:Oral
fda-application-number:
generic:false
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Teva-temazepam
labeller:TEVA Canada Limited
ndc-id:
ndc-product-code:
dpd-id:02230095
ema-product-code:
ema-ma-number:
started-marketing-on:1996-12-18
ended-marketing-on:2018-05-17
dosage-form:Capsule
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
name:Teva-temazepam
labeller:TEVA Canada Limited
ndc-id:
ndc-product-code:
dpd-id:02230102
ema-product-code:
ema-ma-number:
started-marketing-on:1996-12-18
ended-marketing-on:2018-05-17
dosage-form:Capsule
strength:
route:Oral
fda-application-number:
generic:true
over-the-counter:false
approved:true
country:Canada
source:DPD
混合物
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Strazepam
ingredients:Choline + Temazepam
name:Restoril
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:PMS-temazepam
ingredients:Temazepam
name:Nu-temazepam
ingredients:Temazepam
name:Nu-temazepam
ingredients:Temazepam
name:PMS-temazepam - 15mg
ingredients:Temazepam
name:PMS-temazepam - 30mg
ingredients:Temazepam
name:Gen-temazepam 15mg
ingredients:Temazepam
name:Gen-temazepam 30mg
ingredients:Temazepam
name:Ratio-temazepam
ingredients:Temazepam
name:Ratio-temazepam
ingredients:Temazepam
name:Co Temazepam Capsules 15mg
ingredients:Temazepam
name:Co Temazepam Capsules 30mg
ingredients:Temazepam
name:Teva-temazepam
ingredients:Temazepam
name:Teva-temazepam
ingredients:Temazepam
name:Dom-temazepam
ingredients:Temazepam
name:Dom-temazepam
ingredients:Temazepam
name:PHL-temazepam
ingredients:Temazepam
name:PHL-temazepam
ingredients:Temazepam
name:Ntp-temazepam
ingredients:Temazepam
name:Ntp-temazepam
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:Restoril
ingredients:Temazepam
name:PMS-temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam
ingredients:Temazepam
name:Temazepam-15
ingredients:Temazepam
name:Temazepam-30
ingredients:Temazepam
name:Penta-temazepam Capsules
ingredients:Temazepam
name:Penta-temazepam Capsules
ingredients:Temazepam
包装者
name:Actavis Group
url:http://www.actavis.com
name:Aidarex Pharmacuticals LLC
url:http://www.aidarex.com
name:Amerisource Health Services Corp.
url:http://www.amerisourcebergen.com
name:A-S Medication Solutions LLC
url:http://orders.a-smeds.com
name:Ascend Laboratories LLC
url:http://www.ascendlaboratories.com
name:Bryant Ranch Prepack
url:http://bryantranchprepack.com
name:Cardinal Health
url:http://www.cardinal.com
name:Caremark LLC
url:http://www.caremark.com
name:Corepharma LLC
url:http://www.corepharma.com
name:D.M. Graham Laboratories Inc.
url:
name:Direct Dispensing Inc.
url:
name:Dispensing Solutions
url:http://www.drxdispensing.com
name:Diversified Healthcare Services Inc.
url:http://www.dhscorp.com
name:H.J. Harkins Co. Inc.
url:http://hjharkinscompanyinc.com
name:Heartland Repack Services LLC
url:
name:Innoviant Pharmacy Inc.
url:http://www.innoviantpharmacy.com
name:Kaiser Foundation Hospital
url:
name:Keltman Pharmaceuticals Inc.
url:http://www.keltman.com
name:Lake Erie Medical and Surgical Supply
url:
name:Liberty Pharmaceuticals
url:
name:Major Pharmaceuticals
url:http://www.majorpharmaceuticals.com
name:Mallinckrodt Inc.
url:http://www.mallinckrodt.com
name:Mckesson Corp.
url:http://www.mckesson.com
name:Murfreesboro Pharmaceutical Nursing Supply
url:http://www.unitdosesupply.com
name:Mutual Pharmaceutical Co.
url:
name:Mylan
url:http://www.mylan.com
name:Novartis AG
url:http://www.novartis.com
name:Novel Laboratories Inc.
url:http://www.novellabs.net
name:Nucare Pharmaceuticals Inc.
url:http://www.nucarerx.com
name:Palmetto Pharmaceuticals Inc.
url:http://www.palmettopharm.com
name:PD-Rx Pharmaceuticals Inc.
url:http://www.pdrx.com
name:Pharmedix
url:http://www.pharmedixrx.com
name:Physicians Total Care Inc.
url:http://www.physicianstotalcare.com
name:Preferred Pharmaceuticals Inc.
url:http://www.preferredpharmaceuticals.com
name:Prepackage Specialists
url:
name:Prepak Systems Inc.
url:http://www.prepaksys.com
name:Rebel Distributors Corp.
url:http://www.rebelrx.com
name:Remedy Repack
url:http://www.remedyrepack.com
name:Sandhills Packaging Inc.
url:http://www.sandhillspackaging.com
name:Sandoz
url:http://www.sandoz.ca
name:Southwood Pharmaceuticals
url:http://www.southwoodhealthcare.com
name:St Mary's Medical Park Pharmacy
url:
name:Stat Rx Usa
url:http://statrxusa.exporterus.com
name:Sunbreaker Usa
url:
name:UDL Laboratories
url:http://www.udllabs.com
name:Va Cmop Dallas
url:
生产者
generic:否; url:; name;Tyco healthcare group lp
generic:否; url:; name;Quantum pharmics ltd
generic:是; url:; name;Actavis elizabeth llc
generic:是; url:; name;Duramed pharmaceuticals inc sub barr laboratories inc
generic:是; url:; name;Mutual pharmaceutical co inc
generic:是; url:; name;Mylan pharmaceuticals inc
generic:是; url:; name;Novel laboratories inc
generic:是; url:; name;Sandoz inc
generic:是; url:; name;Usl pharma inc
generic:是; url:; name;Watson laboratories inc
价格
Restoril 30 mg capsule
7.67(单位:USD)
capsule
Restoril 15 mg capsule
7.87(单位:USD)
capsule
Temazepam 22.5 mg capsule
9.94(单位:USD)
capsule
Temazepam 7.5 mg capsule
9.94(单位:USD)
capsule
Restoril 22.5 mg capsule
11.37(单位:USD)
capsule
Restoril 7.5 mg capsule
11.37(单位:USD)
capsule
Apo-Temazepam 15 mg Capsule
0.12(单位:USD)
capsule
Co Temazepam 15 mg Capsule
0.12(单位:USD)
capsule
Novo-Temazepam 15 mg Capsule
0.12(单位:USD)
capsule
Pms-Temazepam 15 mg Capsule
0.12(单位:USD)
capsule
Ratio-Temazepam 15 mg Capsule
0.12(单位:USD)
capsule
Apo-Temazepam 30 mg Capsule
0.14(单位:USD)
capsule
Co Temazepam 30 mg Capsule
0.14(单位:USD)
capsule
Novo-Temazepam 30 mg Capsule
0.14(单位:USD)
capsule
Pms-Temazepam 30 mg Capsule
0.14(单位:USD)
capsule
Ratio-Temazepam 30 mg Capsule
0.14(单位:USD)
capsule
Temazepam 15 mg capsule
0.58(单位:USD)
capsule
Temazepam 30 mg capsule
0.69(单位:USD)
capsule
受影响的生物体
Humans and other mammals
剂量
form:Capsule
route:Oral
strength:5 MG
form:Solution / drops
route:
strength:0.5 %
form:Suppository
route:
strength:10 MG
form:Suppository
route:
strength:20 MG
form:Suppository
route:
strength:5 MG
form:Capsule
route:Oral
strength:20 MG
form:Capsule
route:Oral
strength:10 MG
form:Capsule
route:Oral
strength:15 mg
form:Capsule
route:Oral
strength:30 mg
form:Kit
route:Oral
strength:
form:Capsule
route:Oral
strength:
form:Capsule
route:Oral
strength:15 mg/1
form:Capsule
route:Oral
strength:22.5 mg/1
form:Capsule
route:Oral
strength:30 mg/1
form:Capsule
route:Oral
strength:7.5 mg/1
atc代码
Benzodiazepine derivatives
HYPNOTICS AND SEDATIVES
PSYCHOLEPTICS
NERVOUS SYSTEM
fda标签
//s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00231.pdf?1551223963
化学品安全技术说明书
//s3-us-west-2.amazonaws.com/drugbank/msds/DB00231.pdf?1551224326
专利
number:5211954
country:United States
approved:1993-05-18
expires:2010-05-18
pediatric-extension:否
食物相互作用
Avoid alcohol.Take with or without food.
药物相互作用
DB00921
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
DB00366
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB00470
Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB00450
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Droperidol.
DB00956
Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB00557
Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB00653
The therapeutic efficacy of Temazepam can be increased when used in combination with Magnesium sulfate.
DB01403
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
DB00765
Temazepam may increase the sedative activities of Metyrosine.
DB01017
Minocycline may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB00370
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
DB00486
Nabilone may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB01173
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
DB09117
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
DB08883
Perampanel may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB00413
Temazepam may increase the sedative activities of Pramipexole.
DB00268
Temazepam may increase the sedative activities of Ropinirole.
DB05271
Temazepam may increase the sedative activities of Rotigotine.
DB06201
The risk or severity of adverse effects can be increased when Rufinamide is combined with Temazepam.
DB09034
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
DB06204
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB01041
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
DB00425
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
DB00363
The risk or severity of adverse effects can be increased when Temazepam is combined with Clozapine.
DB00333
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
DB09072
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
DB08900
The serum concentration of Temazepam can be increased when it is combined with Teduglutide.
DB01392
The therapeutic efficacy of Temazepam can be increased when used in combination with Yohimbine.
DB01205
Flumazenil may decrease the sedative activities of Temazepam.
DB00898
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
DB00972
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
DB00484
Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
DB04832
The risk or severity of adverse effects can be increased when Temazepam is combined with Zimelidine.
DB04884
The risk or severity of adverse effects can be increased when Temazepam is combined with Dapoxetine.
DB06731
The risk or severity of adverse effects can be increased when Temazepam is combined with Seproxetine.
DB00176
The risk or severity of adverse effects can be increased when Fluvoxamine is combined with Temazepam.
DB00215
The risk or severity of adverse effects can be increased when Citalopram is combined with Temazepam.
DB00476
The risk or severity of adverse effects can be increased when Temazepam is combined with Duloxetine.
DB00656
The risk or severity of adverse effects can be increased when Temazepam is combined with Trazodone.
DB00715
The risk or severity of adverse effects can be increased when Temazepam is combined with Paroxetine.
DB01104
The risk or severity of adverse effects can be increased when Temazepam is combined with Sertraline.
DB01105
The risk or severity of adverse effects can be increased when Temazepam is combined with Sibutramine.
DB01149
The risk or severity of adverse effects can be increased when Temazepam is combined with Nefazodone.
DB01175
The risk or severity of adverse effects can be increased when Temazepam is combined with Escitalopram.
DB04896
The risk or severity of adverse effects can be increased when Temazepam is combined with Milnacipran.
DB06700
The risk or severity of adverse effects can be increased when Temazepam is combined with Desvenlafaxine.
DB08918
The risk or severity of adverse effects can be increased when Temazepam is combined with Levomilnacipran.
DB08953
The risk or severity of adverse effects can be increased when Temazepam is combined with Indalpine.
DB12693
The risk or severity of adverse effects can be increased when Temazepam is combined with Ritanserin.
DB13233
The risk or severity of adverse effects can be increased when Temazepam is combined with Alaproclate.
DB00209
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00219
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Oxyphenonium.
DB00245
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
DB00280
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
DB00332
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Ipratropium.
DB00340
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Metixene.
DB00354
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Buclizine.
DB00376
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
DB00383
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Oxyphencyclimine.
DB00387
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Procyclidine.
DB00392
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Profenamine.
DB00424
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
DB00434
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
DB00462
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Methscopolamine bromide.
DB00505
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Tridihexethyl.
DB00517
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Anisotropine methylbromide.
DB00572
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Atropine.
DB00670
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Pirenzepine.
DB00725
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Homatropine methylbromide.
DB00767
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Benzquinamide.
DB00777
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
DB00782
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
DB00804
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
DB00810
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Biperiden.
DB00940
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Methantheline.
DB00942
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Cycrimine.
DB00986
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
DB01036
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
DB01148
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
DB01231
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Diphenidol.
DB01409
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Tiotropium.
DB01591
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
DB01625
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Isopropamide.
DB04843
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Mepenzolate.
DB06702
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
DB06787
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
DB08801
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Dimetindene.
DB08897
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
DB08997
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Dexetimide.
DB09076
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Umeclidinium.
DB09089
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Trimebutine.
DB09262
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Imidafenacin.
DB09300
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Butylscopolamine.
DB11235
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Thonzylamine.
DB11315
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Methscopolamine.
DB11855
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Revefenacin.
DB12086
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Oxitropium.
DB12278
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Propiverine.
DB12526
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Batefenterol.
DB12554
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Mebeverine.
DB13252
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Tropatepine.
DB13254
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Prifinium.
DB13351
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Piperidolate.
DB13369
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Benzilone.
DB13380
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Difemerine.
DB13413
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Phenglutarimide.
DB13448
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Mazaticol.
DB13468
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Etybenzatropine.
DB13500
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Otilonium.
DB13507
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Poldine.
DB13542
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Bevonium.
DB13581
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Rociverine.
DB13619
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Bornaprine.
DB13636
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Etanautine.
DB13666
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Tiemonium iodide.
DB13678
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Dihexyverine.
DB13695
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Penthienate.
DB13720
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Diphemanil.
DB13738
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Camylofin.
DB13759
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Fenpiverinium.
DB13769
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Emetonium iodide.
DB13844
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Pipenzolate.
DB13850
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Timepidium.
DB00342
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Terfenadine.
DB00496
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
DB00622
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Nicardipine.
DB00907
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Cocaine.
DB01062
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
DB00321
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
DB00458
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
DB01142
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DB01151
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
DB09007
Temazepam may increase the central nervous system depressant (CNS depressant) activities of Chlorphenoxamine.
DB01198
The risk or severity of adverse effects can be increased when Temazepam is combined with Zopiclone.
DB00201
The therapeutic efficacy of Temazepam can be decreased when used in combination with Caffeine.
DB00651
The therapeutic efficacy of Temazepam can be decreased when used in combination with Dyphylline.
DB00806
The therapeutic efficacy of Temazepam can be decreased when used in combination with Pentoxifylline.
DB01033
The therapeutic efficacy of Temazepam can be decreased when used in combination with Mercaptopurine.
DB01303
The therapeutic efficacy of Temazepam can be decreased when used in combination with Oxtriphylline.
DB01412
The therapeutic efficacy of Temazepam can be decreased when used in combination with Theobromine.
DB01482
The therapeutic efficacy of Temazepam can be decreased when used in combination with Fenethylline.
DB01667
The therapeutic efficacy of Temazepam can be decreased when used in combination with 8-azaguanine.
DB01978
The therapeutic efficacy of Temazepam can be decreased when used in combination with 7,9-Dimethylguanine.
DB02134
The therapeutic efficacy of Temazepam can be decreased when used in combination with Xanthine.
DB02245
The therapeutic efficacy of Temazepam can be decreased when used in combination with 7-Deazaguanine.
DB02377
The therapeutic efficacy of Temazepam can be decreased when used in combination with Guanine.
DB02489
The therapeutic efficacy of Temazepam can be decreased when used in combination with 9-Methylguanine.
DB02568
The therapeutic efficacy of Temazepam can be decreased when used in combination with Peldesine.
DB04076
The therapeutic efficacy of Temazepam can be decreased when used in combination with Hypoxanthine.
DB04356
The therapeutic efficacy of Temazepam can be decreased when used in combination with 9-Deazaguanine.
DB06479
The therapeutic efficacy of Temazepam can be decreased when used in combination with Propentofylline.
DB06575
The therapeutic efficacy of Temazepam can be decreased when used in combination with Valomaciclovir.
DB07954
The therapeutic efficacy of Temazepam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
DB08844
The therapeutic efficacy of Temazepam can be decreased when used in combination with Uric acid.
DB09273
The therapeutic efficacy of Temazepam can be decreased when used in combination with Doxofylline.
DB11919
The therapeutic efficacy of Temazepam can be decreased when used in combination with 6-O-benzylguanine.
DB12406
The therapeutic efficacy of Temazepam can be decreased when used in combination with Lisofylline.
DB12531
The therapeutic efficacy of Temazepam can be decreased when used in combination with Lobucavir.
DB12926
The therapeutic efficacy of Temazepam can be decreased when used in combination with Cafedrine.
DB12927
The therapeutic efficacy of Temazepam can be decreased when used in combination with Theodrenaline.
DB13203
The therapeutic efficacy of Temazepam can be decreased when used in combination with Bamifylline.
DB13449
The therapeutic efficacy of Temazepam can be decreased when used in combination with Proxyphylline.
DB13573
The therapeutic efficacy of Temazepam can be decreased when used in combination with Acefylline.
DB13592
The therapeutic efficacy of Temazepam can be decreased when used in combination with Etamiphylline.
DB13634
The therapeutic efficacy of Temazepam can be decreased when used in combination with Pentifylline.
DB13812
The therapeutic efficacy of Temazepam can be decreased when used in combination with Bufylline.
DB14018
The therapeutic efficacy of Temazepam can be decreased when used in combination with Bromotheophylline.
DB14029
The therapeutic efficacy of Temazepam can be decreased when used in combination with Furafylline.
DB14132
The therapeutic efficacy of Temazepam can be decreased when used in combination with 8-chlorotheophylline.
DB15122
The therapeutic efficacy of Temazepam can be decreased when used in combination with PCS-499.
DB00277
The therapeutic efficacy of Temazepam can be decreased when used in combination with Theophylline.
DB01223
The therapeutic efficacy of Temazepam can be decreased when used in combination with Aminophylline.
DB00042
The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Temazepam.
DB00083
The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Temazepam.
DB00181
The risk or severity of adverse effects can be increased when Baclofen is combined with Temazepam.
DB00189
The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Temazepam.
DB00202
The risk or severity of adverse effects can be increased when Succinylcholine is combined with Temazepam.
DB00228
The risk or severity of adverse effects can be increased when Enflurane is combined with Temazepam.
DB00237
The risk or severity of adverse effects can be increased when Temazepam is combined with Butabarbital.
DB00241
The risk or severity of adverse effects can be increased when Temazepam is combined with Butalbital.
DB00248
The risk or severity of adverse effects can be increased when Temazepam is combined with Cabergoline.
DB00273
The risk or severity of adverse effects can be increased when Temazepam is combined with Topiramate.
DB00283
The risk or severity of adverse effects can be increased when Temazepam is combined with Clemastine.
DB00289
The risk or severity of adverse effects can be increased when Temazepam is combined with Atomoxetine.
DB00292
The risk or severity of adverse effects can be increased when Temazepam is combined with Etomidate.
DB00306
The risk or severity of adverse effects can be increased when Temazepam is combined with Talbutal.
DB00315
The risk or severity of adverse effects can be increased when Temazepam is combined with Zolmitriptan.
DB00323
The risk or severity of adverse effects can be increased when Temazepam is combined with Tolcapone.
DB00341
The risk or severity of adverse effects can be increased when Temazepam is combined with Cetirizine.
DB00347
The risk or severity of adverse effects can be increased when Temazepam is combined with Trimethadione.
DB00356
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlorzoxazone.
DB00372
The risk or severity of adverse effects can be increased when Temazepam is combined with Thiethylperazine.
DB00405
The risk or severity of adverse effects can be increased when Temazepam is combined with Dexbrompheniramine.
DB00416
The risk or severity of adverse effects can be increased when Temazepam is combined with Metocurine iodide.
DB00423
The risk or severity of adverse effects can be increased when Temazepam is combined with Methocarbamol.
DB00427
The risk or severity of adverse effects can be increased when Temazepam is combined with Triprolidine.
DB00463
The risk or severity of adverse effects can be increased when Temazepam is combined with Metharbital.
DB00468
The risk or severity of adverse effects can be increased when Temazepam is combined with Quinine.
DB00474
The risk or severity of adverse effects can be increased when Temazepam is combined with Methohexital.
DB00483
The risk or severity of adverse effects can be increased when Temazepam is combined with Gallamine triethiodide.
DB00494
The risk or severity of adverse effects can be increased when Temazepam is combined with Entacapone.
DB00532
The risk or severity of adverse effects can be increased when Temazepam is combined with Mephenytoin.
DB00565
The risk or severity of adverse effects can be increased when Temazepam is combined with Cisatracurium.
DB00574
The risk or severity of adverse effects can be increased when Temazepam is combined with Fenfluramine.
DB00579
The risk or severity of adverse effects can be increased when Temazepam is combined with Mazindol.
DB00589
The risk or severity of adverse effects can be increased when Temazepam is combined with Lisuride.
DB00599
The risk or severity of adverse effects can be increased when Temazepam is combined with Thiopental.
DB00601
The risk or severity of adverse effects can be increased when Temazepam is combined with Linezolid.
DB00614
The risk or severity of adverse effects can be increased when Temazepam is combined with Furazolidone.
DB00617
The risk or severity of adverse effects can be increased when Temazepam is combined with Paramethadione.
DB00633
The risk or severity of adverse effects can be increased when Temazepam is combined with Dexmedetomidine.
DB00645
The risk or severity of adverse effects can be increased when Temazepam is combined with Dyclonine.
DB00660
The risk or severity of adverse effects can be increased when Temazepam is combined with Metaxalone.
DB00662
The risk or severity of adverse effects can be increased when Temazepam is combined with Trimethobenzamide.
DB00680
The risk or severity of adverse effects can be increased when Temazepam is combined with Moricizine.
DB00697
The risk or severity of adverse effects can be increased when Temazepam is combined with Tizanidine.
DB00714
The risk or severity of adverse effects can be increased when Temazepam is combined with Apomorphine.
DB00721
The risk or severity of adverse effects can be increased when Temazepam is combined with Procaine.
DB00728
The risk or severity of adverse effects can be increased when Temazepam is combined with Rocuronium.
DB00732
The risk or severity of adverse effects can be increased when Temazepam is combined with Atracurium besylate.
DB00737
The risk or severity of adverse effects can be increased when Temazepam is combined with Meclizine.
DB00740
The risk or severity of adverse effects can be increased when Temazepam is combined with Riluzole.
DB00747
The risk or severity of adverse effects can be increased when Temazepam is combined with Scopolamine.
DB00748
The risk or severity of adverse effects can be increased when Temazepam is combined with Carbinoxamine.
DB00753
The risk or severity of adverse effects can be increased when Temazepam is combined with Isoflurane.
DB00754
The risk or severity of adverse effects can be increased when Temazepam is combined with Ethotoin.
DB00757
The risk or severity of adverse effects can be increased when Temazepam is combined with Dolasetron.
DB00771
The risk or severity of adverse effects can be increased when Temazepam is combined with Clidinium.
DB00818
The risk or severity of adverse effects can be increased when Temazepam is combined with Propofol.
DB00819
The risk or severity of adverse effects can be increased when Temazepam is combined with Acetazolamide.
DB00832
The risk or severity of adverse effects can be increased when Temazepam is combined with Phensuximide.
DB00835
The risk or severity of adverse effects can be increased when Temazepam is combined with Brompheniramine.
DB00843
The risk or severity of adverse effects can be increased when Temazepam is combined with Donepezil.
DB00849
The risk or severity of adverse effects can be increased when Temazepam is combined with Methylphenobarbital.
DB00866
The risk or severity of adverse effects can be increased when Temazepam is combined with Alprenolol.
DB00889
The risk or severity of adverse effects can be increased when Temazepam is combined with Granisetron.
DB00906
The risk or severity of adverse effects can be increased when Temazepam is combined with Tiagabine.
DB00909
The risk or severity of adverse effects can be increased when Temazepam is combined with Zonisamide.
DB00937
The risk or severity of adverse effects can be increased when Temazepam is combined with Diethylpropion.
DB00941
The risk or severity of adverse effects can be increased when Temazepam is combined with Hexafluronium.
DB00952
The risk or severity of adverse effects can be increased when Temazepam is combined with Naratriptan.
DB00962
The risk or severity of adverse effects can be increased when Temazepam is combined with Zaleplon.
DB00967
The risk or severity of adverse effects can be increased when Temazepam is combined with Desloratadine.
DB00969
The risk or severity of adverse effects can be increased when Temazepam is combined with Alosetron.
DB00980
The risk or severity of adverse effects can be increased when Temazepam is combined with Ramelteon.
DB00985
The risk or severity of adverse effects can be increased when Temazepam is combined with Dimenhydrinate.
DB00998
The risk or severity of adverse effects can be increased when Temazepam is combined with Frovatriptan.
DB01018
The risk or severity of adverse effects can be increased when Temazepam is combined with Guanfacine.
DB01028
The risk or severity of adverse effects can be increased when Temazepam is combined with Methoxyflurane.
DB01049
The risk or severity of adverse effects can be increased when Temazepam is combined with Ergoloid mesylate.
DB01063
The risk or severity of adverse effects can be increased when Temazepam is combined with Acetophenazine.
DB01065
The risk or severity of adverse effects can be increased when Temazepam is combined with Melatonin.
DB01068
The risk or severity of adverse effects can be increased when Temazepam is combined with Clonazepam.
DB01069
The risk or severity of adverse effects can be increased when Temazepam is combined with Promethazine.
DB01075
The risk or severity of adverse effects can be increased when Temazepam is combined with Diphenhydramine.
DB01080
The risk or severity of adverse effects can be increased when Temazepam is combined with Vigabatrin.
DB01107
The risk or severity of adverse effects can be increased when Temazepam is combined with Methyprylon.
DB01114
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlorpheniramine.
DB01121
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenacemide.
DB01135
The risk or severity of adverse effects can be increased when Temazepam is combined with Doxacurium.
DB01154
The risk or severity of adverse effects can be increased when Temazepam is combined with Thiamylal.
DB01159
The risk or severity of adverse effects can be increased when Temazepam is combined with Halothane.
DB01168
The risk or severity of adverse effects can be increased when Temazepam is combined with Procarbazine.
DB01176
The risk or severity of adverse effects can be increased when Temazepam is combined with Cyclizine.
DB01186
The risk or severity of adverse effects can be increased when Temazepam is combined with Pergolide.
DB01189
The risk or severity of adverse effects can be increased when Temazepam is combined with Desflurane.
DB01199
The risk or severity of adverse effects can be increased when Temazepam is combined with Tubocurarine.
DB01202
The risk or severity of adverse effects can be increased when Temazepam is combined with Levetiracetam.
DB01219
The risk or severity of adverse effects can be increased when Temazepam is combined with Dantrolene.
DB01221
The risk or severity of adverse effects can be increased when Temazepam is combined with Ketamine.
DB01226
The risk or severity of adverse effects can be increased when Temazepam is combined with Mivacurium.
DB01235
The risk or severity of adverse effects can be increased when Temazepam is combined with Levodopa.
DB01236
The risk or severity of adverse effects can be increased when Temazepam is combined with Sevoflurane.
DB01245
The risk or severity of adverse effects can be increased when Temazepam is combined with Decamethonium.
DB01246
The risk or severity of adverse effects can be increased when Temazepam is combined with Alimemazine.
DB01253
The risk or severity of adverse effects can be increased when Temazepam is combined with Ergometrine.
DB01336
The risk or severity of adverse effects can be increased when Temazepam is combined with Metocurine.
DB01337
The risk or severity of adverse effects can be increased when Temazepam is combined with Pancuronium.
DB01338
The risk or severity of adverse effects can be increased when Temazepam is combined with Pipecuronium.
DB01339
The risk or severity of adverse effects can be increased when Temazepam is combined with Vecuronium.
DB01351
The risk or severity of adverse effects can be increased when Temazepam is combined with Amobarbital.
DB01352
The risk or severity of adverse effects can be increased when Temazepam is combined with Aprobarbital.
DB01353
The risk or severity of adverse effects can be increased when Temazepam is combined with Butobarbital.
DB01354
The risk or severity of adverse effects can be increased when Temazepam is combined with Heptabarbital.
DB01355
The risk or severity of adverse effects can be increased when Temazepam is combined with Hexobarbital.
DB01437
The risk or severity of adverse effects can be increased when Temazepam is combined with Glutethimide.
DB01440
The risk or severity of adverse effects can be increased when Temazepam is combined with gamma-Hydroxybutyric acid.
DB01442
The risk or severity of adverse effects can be increased when Temazepam is combined with MMDA.
DB01483
The risk or severity of adverse effects can be increased when Temazepam is combined with Barbital.
DB01489
The risk or severity of adverse effects can be increased when Temazepam is combined with Camazepam.
DB01495
The risk or severity of adverse effects can be increased when Temazepam is combined with Dichloralphenazone.
DB01501
The risk or severity of adverse effects can be increased when Temazepam is combined with Difenoxin.
DB01511
The risk or severity of adverse effects can be increased when Temazepam is combined with Delorazepam.
DB01534
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlorhexadol.
DB01547
The risk or severity of adverse effects can be increased when Temazepam is combined with Drotebanol.
DB01553
The risk or severity of adverse effects can be increased when Temazepam is combined with Cloxazolam.
DB01559
The risk or severity of adverse effects can be increased when Temazepam is combined with Clotiazepam.
DB01563
The risk or severity of adverse effects can be increased when Temazepam is combined with Chloral hydrate.
DB01580
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxprenolol.
DB01589
The risk or severity of adverse effects can be increased when Temazepam is combined with Quazepam.
DB01594
The risk or severity of adverse effects can be increased when Temazepam is combined with Cinolazepam.
DB01608
The risk or severity of adverse effects can be increased when Temazepam is combined with Periciazine.
DB01616
The risk or severity of adverse effects can be increased when Temazepam is combined with Alverine.
DB01621
The risk or severity of adverse effects can be increased when Temazepam is combined with Pipotiazine.
DB01622
The risk or severity of adverse effects can be increased when Temazepam is combined with Thioproperazine.
DB01626
The risk or severity of adverse effects can be increased when Temazepam is combined with Pargyline.
DB02234
The risk or severity of adverse effects can be increased when Temazepam is combined with S-Ethylisothiourea.
DB02852
The risk or severity of adverse effects can be increased when Temazepam is combined with Domoic Acid.
DB04165
The risk or severity of adverse effects can be increased when Temazepam is combined with Valpromide.
DB04819
The risk or severity of adverse effects can be increased when Temazepam is combined with Methapyrilene.
DB04821
The risk or severity of adverse effects can be increased when Temazepam is combined with Nomifensine.
DB04827
The risk or severity of adverse effects can be increased when Temazepam is combined with Urethane.
DB04833
The risk or severity of adverse effects can be increased when Temazepam is combined with Methaqualone.
DB04834
The risk or severity of adverse effects can be increased when Temazepam is combined with Rapacuronium.
DB04841
The risk or severity of adverse effects can be increased when Temazepam is combined with Flunarizine.
DB04885
The risk or severity of adverse effects can be increased when Temazepam is combined with Cilansetron.
DB04888
The risk or severity of adverse effects can be increased when Temazepam is combined with Bifeprunox.
DB04903
The risk or severity of adverse effects can be increased when Temazepam is combined with Pagoclone.
DB04908
The risk or severity of adverse effects can be increased when Temazepam is combined with Flibanserin.
DB04917
The risk or severity of adverse effects can be increased when Temazepam is combined with Renzapride.
DB04953
The risk or severity of adverse effects can be increased when Temazepam is combined with Ezogabine.
DB05227
The risk or severity of adverse effects can be increased when Temazepam is combined with APD791.
DB05232
The risk or severity of adverse effects can be increased when Temazepam is combined with Tetrodotoxin.
DB05246
The risk or severity of adverse effects can be increased when Temazepam is combined with Methsuximide.
DB05541
The risk or severity of adverse effects can be increased when Temazepam is combined with Brivaracetam.
DB05542
The risk or severity of adverse effects can be increased when Temazepam is combined with Naronapride.
DB05562
The risk or severity of adverse effects can be increased when Temazepam is combined with Naluzotan.
DB05607
The risk or severity of adverse effects can be increased when Temazepam is combined with PRX-08066.
DB05687
The risk or severity of adverse effects can be increased when Temazepam is combined with BL-1020.
DB05710
The risk or severity of adverse effects can be increased when Temazepam is combined with Gantacurium.
DB06077
The risk or severity of adverse effects can be increased when Temazepam is combined with Lumateperone.
DB06109
The risk or severity of adverse effects can be increased when Temazepam is combined with YKP-1358.
DB06218
The risk or severity of adverse effects can be increased when Temazepam is combined with Lacosamide.
DB06264
The risk or severity of adverse effects can be increased when Temazepam is combined with Tolperisone.
DB06282
The risk or severity of adverse effects can be increased when Temazepam is combined with Levocetirizine.
DB06446
The risk or severity of adverse effects can be increased when Temazepam is combined with Dotarizine.
DB06458
The risk or severity of adverse effects can be increased when Temazepam is combined with Remacemide.
DB06470
The risk or severity of adverse effects can be increased when Temazepam is combined with Clomethiazole.
DB06527
The risk or severity of adverse effects can be increased when Temazepam is combined with Tramiprosate.
DB06529
The risk or severity of adverse effects can be increased when Temazepam is combined with Ocinaplon.
DB06554
The risk or severity of adverse effects can be increased when Temazepam is combined with Gaboxadol.
DB06660
The risk or severity of adverse effects can be increased when Temazepam is combined with Saredutant.
DB06690
The risk or severity of adverse effects can be increased when Temazepam is combined with Nitrous oxide.
DB06691
The risk or severity of adverse effects can be increased when Temazepam is combined with Mepyramine.
DB06701
The risk or severity of adverse effects can be increased when Temazepam is combined with Dexmethylphenidate.
DB06716
The risk or severity of adverse effects can be increased when Temazepam is combined with Fospropofol.
DB06753
The risk or severity of adverse effects can be increased when Temazepam is combined with Triclofos.
DB06770
The risk or severity of adverse effects can be increased when Temazepam is combined with Benzyl alcohol.
DB06797
The risk or severity of adverse effects can be increased when Temazepam is combined with Mebutamate.
DB08059
The risk or severity of adverse effects can be increased when Temazepam is combined with Wortmannin.
DB08329
The risk or severity of adverse effects can be increased when Temazepam is combined with Sulthiame.
DB08550
The risk or severity of adverse effects can be increased when Temazepam is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
DB08810
The risk or severity of adverse effects can be increased when Temazepam is combined with Cinitapride.
DB08839
The risk or severity of adverse effects can be increased when Temazepam is combined with Serotonin.
DB08872
The risk or severity of adverse effects can be increased when Temazepam is combined with Gabapentin enacarbil.
DB08892
The risk or severity of adverse effects can be increased when Temazepam is combined with Arbaclofen Placarbil.
DB08910
The risk or severity of adverse effects can be increased when Temazepam is combined with Pomalidomide.
DB08954
The risk or severity of adverse effects can be increased when Temazepam is combined with Ifenprodil.
DB08960
The risk or severity of adverse effects can be increased when Temazepam is combined with Hexamethonium.
DB08992
The risk or severity of adverse effects can be increased when Temazepam is combined with Eperisone.
DB09000
The risk or severity of adverse effects can be increased when Temazepam is combined with Cyamemazine.
DB09001
The risk or severity of adverse effects can be increased when Temazepam is combined with Barbexaclone.
DB09011
The risk or severity of adverse effects can be increased when Temazepam is combined with Beclamide.
DB09014
The risk or severity of adverse effects can be increased when Temazepam is combined with Captodiame.
DB09017
The risk or severity of adverse effects can be increased when Temazepam is combined with Brotizolam.
DB09021
The risk or severity of adverse effects can be increased when Temazepam is combined with Benzoctamine.
DB09071
The risk or severity of adverse effects can be increased when Temazepam is combined with Tasimelteon.
DB09119
The risk or severity of adverse effects can be increased when Temazepam is combined with Eslicarbazepine acetate.
DB09128
The risk or severity of adverse effects can be increased when Temazepam is combined with Brexpiprazole.
DB09184
The risk or severity of adverse effects can be increased when Temazepam is combined with Edivoxetine.
DB09186
The risk or severity of adverse effects can be increased when Temazepam is combined with Nisoxetine.
DB09187
The risk or severity of adverse effects can be increased when Temazepam is combined with Lortalamine.
DB09190
The risk or severity of adverse effects can be increased when Temazepam is combined with Talopram.
DB09223
The risk or severity of adverse effects can be increased when Temazepam is combined with Blonanserin.
DB09241
The risk or severity of adverse effects can be increased when Temazepam is combined with Methylene blue.
DB09243
The risk or severity of adverse effects can be increased when Temazepam is combined with Hydracarbazine.
DB09246
The risk or severity of adverse effects can be increased when Temazepam is combined with Benmoxin.
DB09247
The risk or severity of adverse effects can be increased when Temazepam is combined with Iproclozide.
DB09248
The risk or severity of adverse effects can be increased when Temazepam is combined with Mebanazine.
DB09249
The risk or severity of adverse effects can be increased when Temazepam is combined with Octamoxin.
DB09250
The risk or severity of adverse effects can be increased when Temazepam is combined with Pheniprazine.
DB09251
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenoxypropazine.
DB09252
The risk or severity of adverse effects can be increased when Temazepam is combined with Pivhydrazine.
DB09253
The risk or severity of adverse effects can be increased when Temazepam is combined with Safrazine.
DB09254
The risk or severity of adverse effects can be increased when Temazepam is combined with Caroxazone.
DB09290
The risk or severity of adverse effects can be increased when Temazepam is combined with Ramosetron.
DB11156
The risk or severity of adverse effects can be increased when Temazepam is combined with Pyrantel.
DB11371
The risk or severity of adverse effects can be increased when Temazepam is combined with Alfaxalone.
DB11400
The risk or severity of adverse effects can be increased when Temazepam is combined with Doramectin.
DB11428
The risk or severity of adverse effects can be increased when Temazepam is combined with Medetomidine.
DB11477
The risk or severity of adverse effects can be increased when Temazepam is combined with Xylazine.
DB11540
The risk or severity of adverse effects can be increased when Temazepam is combined with Propiopromazine.
DB11543
The risk or severity of adverse effects can be increased when Temazepam is combined with Romifidine.
DB11549
The risk or severity of adverse effects can be increased when Temazepam is combined with Tiletamine.
DB11552
The risk or severity of adverse effects can be increased when Temazepam is combined with Tricaine.
DB11556
The risk or severity of adverse effects can be increased when Temazepam is combined with Detomidine.
DB11582
The risk or severity of adverse effects can be increased when Temazepam is combined with Thiocolchicoside.
DB11675
The risk or severity of adverse effects can be increased when Temazepam is combined with Mosapride.
DB11686
The risk or severity of adverse effects can be increased when Temazepam is combined with Iferanserin.
DB11755
The risk or severity of adverse effects can be increased when Temazepam is combined with Tetrahydrocannabivarin.
DB11859
The risk or severity of adverse effects can be increased when Temazepam is combined with Brexanolone.
DB11868
The risk or severity of adverse effects can be increased when Temazepam is combined with Etiracetam.
DB11889
The risk or severity of adverse effects can be increased when Temazepam is combined with Lanicemine.
DB11957
The risk or severity of adverse effects can be increased when Temazepam is combined with Idalopirdine.
DB12071
The risk or severity of adverse effects can be increased when Temazepam is combined with Vabicaserin.
DB12105
The risk or severity of adverse effects can be increased when Temazepam is combined with Imagabalin.
DB12110
The risk or severity of adverse effects can be increased when Temazepam is combined with m-Chlorophenylpiperazine.
DB12111
The risk or severity of adverse effects can be increased when Temazepam is combined with MK-212.
DB12131
The risk or severity of adverse effects can be increased when Temazepam is combined with Vinpocetine.
DB12163
The risk or severity of adverse effects can be increased when Temazepam is combined with Sarpogrelate.
DB12177
The risk or severity of adverse effects can be increased when Temazepam is combined with Eplivanserin.
DB12229
The risk or severity of adverse effects can be increased when Temazepam is combined with Cerlapirdine.
DB12308
The risk or severity of adverse effects can be increased when Temazepam is combined with Eltanolone.
DB12338
The risk or severity of adverse effects can be increased when Temazepam is combined with Carisbamate.
DB12361
The risk or severity of adverse effects can be increased when Temazepam is combined with Piclozotan.
DB12395
The risk or severity of adverse effects can be increased when Temazepam is combined with Esreboxetine.
DB12427
The risk or severity of adverse effects can be increased when Temazepam is combined with Orvepitant.
DB12465
The risk or severity of adverse effects can be increased when Temazepam is combined with Ketanserin.
DB12537
The risk or severity of adverse effects can be increased when Temazepam is combined with Benzodiazepine.
DB12576
The risk or severity of adverse effects can be increased when Temazepam is combined with AZD-3043.
DB12590
The risk or severity of adverse effects can be increased when Temazepam is combined with Indiplon.
DB12661
The risk or severity of adverse effects can be increased when Temazepam is combined with Urapidil.
DB12725
The risk or severity of adverse effects can be increased when Temazepam is combined with TD-8954.
DB12883
The risk or severity of adverse effects can be increased when Temazepam is combined with Eltoprazine.
DB12951
The risk or severity of adverse effects can be increased when Temazepam is combined with Pivagabine.
DB12958
The risk or severity of adverse effects can be increased when Temazepam is combined with Prothipendyl.
DB12989
The risk or severity of adverse effects can be increased when Temazepam is combined with Neosaxitoxin.
DB13099
The risk or severity of adverse effects can be increased when Temazepam is combined with Valnoctamide.
DB13114
The risk or severity of adverse effects can be increased when Temazepam is combined with Amitriptylinoxide.
DB13213
The risk or severity of adverse effects can be increased when Temazepam is combined with Butaperazine.
DB13219
The risk or severity of adverse effects can be increased when Temazepam is combined with Medifoxamine.
DB13221
The risk or severity of adverse effects can be increased when Temazepam is combined with Apronalide.
DB13234
The risk or severity of adverse effects can be increased when Temazepam is combined with Propanidid.
DB13246
The risk or severity of adverse effects can be increased when Temazepam is combined with Quinupramine.
DB13253
The risk or severity of adverse effects can be increased when Temazepam is combined with Proxibarbal.
DB13295
The risk or severity of adverse effects can be increased when Temazepam is combined with Atracurium.
DB13303
The risk or severity of adverse effects can be increased when Temazepam is combined with Febarbamate.
DB13323
The risk or severity of adverse effects can be increased when Temazepam is combined with Trichloroethylene.
DB13324
The risk or severity of adverse effects can be increased when Temazepam is combined with Tetrazepam.
DB13331
The risk or severity of adverse effects can be increased when Temazepam is combined with Pyrithyldione.
DB13354
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenprobamate.
DB13357
The risk or severity of adverse effects can be increased when Temazepam is combined with Styramate.
DB13362
The risk or severity of adverse effects can be increased when Temazepam is combined with Pheneturide.
DB13370
The risk or severity of adverse effects can be increased when Temazepam is combined with Bromisoval.
DB13377
The risk or severity of adverse effects can be increased when Temazepam is combined with Vinbarbital.
DB13382
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlorproethazine.
DB13396
The risk or severity of adverse effects can be increased when Temazepam is combined with Neocitrullamon.
DB13402
The risk or severity of adverse effects can be increased when Temazepam is combined with Acetylglycinamide chloral hydrate.
DB13403
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxypertine.
DB13414
The risk or severity of adverse effects can be increased when Temazepam is combined with Fenyramidol.
DB13420
The risk or severity of adverse effects can be increased when Temazepam is combined with Thiazinam.
DB13457
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxaflozane.
DB13505
The risk or severity of adverse effects can be increased when Temazepam is combined with Emepronium.
DB13520
The risk or severity of adverse effects can be increased when Temazepam is combined with Metergoline.
DB13534
The risk or severity of adverse effects can be increased when Temazepam is combined with Gedocarnil.
DB13541
The risk or severity of adverse effects can be increased when Temazepam is combined with Iprazochrome.
DB13554
The risk or severity of adverse effects can be increased when Temazepam is combined with Moperone.
DB13557
The risk or severity of adverse effects can be increased when Temazepam is combined with Thiopropazate.
DB13572
The risk or severity of adverse effects can be increased when Temazepam is combined with Emylcamate.
DB13577
The risk or severity of adverse effects can be increased when Temazepam is combined with Allobarbital.
DB13584
The risk or severity of adverse effects can be increased when Temazepam is combined with Gallamine.
DB13588
The risk or severity of adverse effects can be increased when Temazepam is combined with Naftidrofuryl.
DB13598
The risk or severity of adverse effects can be increased when Temazepam is combined with Diethyl ether.
DB13623
The risk or severity of adverse effects can be increased when Temazepam is combined with Fabomotizole.
DB13642
The risk or severity of adverse effects can be increased when Temazepam is combined with Pridinol.
DB13648
The risk or severity of adverse effects can be increased when Temazepam is combined with Alcuronium.
DB13662
The risk or severity of adverse effects can be increased when Temazepam is combined with Hexapropymate.
DB13676
The risk or severity of adverse effects can be increased when Temazepam is combined with Mosapramine.
DB13687
The risk or severity of adverse effects can be increased when Temazepam is combined with Niaprazine.
DB13690
The risk or severity of adverse effects can be increased when Temazepam is combined with Vinyl ether.
DB13733
The risk or severity of adverse effects can be increased when Temazepam is combined with Methylpentynol.
DB13737
The risk or severity of adverse effects can be increased when Temazepam is combined with Cyclobarbital.
DB13745
The risk or severity of adverse effects can be increased when Temazepam is combined with Fazadinium bromide.
DB13754
The risk or severity of adverse effects can be increased when Temazepam is combined with Mephenoxalone.
DB13770
The risk or severity of adverse effects can be increased when Temazepam is combined with Vinylbital.
DB13782
The risk or severity of adverse effects can be increased when Temazepam is combined with Imipramine oxide.
DB13799
The risk or severity of adverse effects can be increased when Temazepam is combined with Ethadione.
DB13805
The risk or severity of adverse effects can be increased when Temazepam is combined with Reposal.
DB13817
The risk or severity of adverse effects can be increased when Temazepam is combined with Carbromal.
DB13837
The risk or severity of adverse effects can be increased when Temazepam is combined with Doxefazepam.
DB13872
The risk or severity of adverse effects can be increased when Temazepam is combined with Lormetazepam.
DB13875
The risk or severity of adverse effects can be increased when Temazepam is combined with Harmaline.
DB13876
The risk or severity of adverse effects can be increased when Temazepam is combined with Brofaromine.
DB13940
The risk or severity of adverse effects can be increased when Temazepam is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
DB13948
The risk or severity of adverse effects can be increased when Temazepam is combined with N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine.
DB13984
The risk or severity of adverse effects can be increased when Temazepam is combined with Cyclopropane.
DB13993
The risk or severity of adverse effects can be increased when Temazepam is combined with MRK-409.
DB14010
The risk or severity of adverse effects can be increased when Temazepam is combined with 5-methoxy-N,N-dimethyltryptamine.
DB14050
The risk or severity of adverse effects can be increased when Temazepam is combined with Cannabidivarin.
DB14575
The risk or severity of adverse effects can be increased when Temazepam is combined with Eslicarbazepine.
DB14651
The risk or severity of adverse effects can be increased when Temazepam is combined with Perphenazine enanthate.
DB14672
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxazepam acetate.
DB14715
The risk or severity of adverse effects can be increased when Temazepam is combined with Cinazepam.
DB14718
The risk or severity of adverse effects can be increased when Temazepam is combined with Pyrazolam.
DB14719
The risk or severity of adverse effects can be increased when Temazepam is combined with Bentazepam.
DB14754
The risk or severity of adverse effects can be increased when Temazepam is combined with Solriamfetol.
DB15203
The risk or severity of adverse effects can be increased when Temazepam is combined with JNJ-26489112.
DB00182
The risk or severity of adverse effects can be increased when Amphetamine is combined with Temazepam.
DB00377
The risk or severity of adverse effects can be increased when Temazepam is combined with Palonosetron.
DB00669
The risk or severity of adverse effects can be increased when Temazepam is combined with Sumatriptan.
DB00918
The risk or severity of adverse effects can be increased when Temazepam is combined with Almotriptan.
DB00953
The risk or severity of adverse effects can be increased when Temazepam is combined with Rizatriptan.
DB00960
The risk or severity of adverse effects can be increased when Temazepam is combined with Pindolol.
DB01359
The risk or severity of adverse effects can be increased when Temazepam is combined with Penbutolol.
DB01367
The risk or severity of adverse effects can be increased when Temazepam is combined with Rasagiline.
DB01577
The risk or severity of adverse effects can be increased when Temazepam is combined with Metamfetamine.
DB04871
The risk or severity of adverse effects can be increased when Temazepam is combined with Lorcaserin.
DB09194
The risk or severity of adverse effects can be increased when Temazepam is combined with Etoperidone.
DB11699
The risk or severity of adverse effects can be increased when Temazepam is combined with Tropisetron.
DB00216
The risk or severity of adverse effects can be increased when Eletriptan is combined with Temazepam.
DB00247
The risk or severity of adverse effects can be increased when Temazepam is combined with Methysergide.
DB00252
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenytoin.
DB00312
The risk or severity of adverse effects can be increased when Temazepam is combined with Pentobarbital.
DB00320
The risk or severity of adverse effects can be increased when Temazepam is combined with Dihydroergotamine.
DB00418
The risk or severity of adverse effects can be increased when Temazepam is combined with Secobarbital.
DB00514
The risk or severity of adverse effects can be increased when Temazepam is combined with Dextromethorphan.
DB00588
The risk or severity of adverse effects can be increased when Temazepam is combined with Fluticasone propionate.
DB00593
The risk or severity of adverse effects can be increased when Temazepam is combined with Ethosuximide.
DB00604
The risk or severity of adverse effects can be increased when Temazepam is combined with Cisapride.
DB00625
The risk or severity of adverse effects can be increased when Temazepam is combined with Efavirenz.
DB00696
The risk or severity of adverse effects can be increased when Temazepam is combined with Ergotamine.
DB00776
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxcarbazepine.
DB00794
The risk or severity of adverse effects can be increased when Temazepam is combined with Primidone.
DB00865
The risk or severity of adverse effects can be increased when Temazepam is combined with Benzphetamine.
DB00949
The risk or severity of adverse effects can be increased when Temazepam is combined with Felbamate.
DB01174
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenobarbital.
DB01200
The risk or severity of adverse effects can be increased when Temazepam is combined with Bromocriptine.
DB01320
The risk or severity of adverse effects can be increased when Temazepam is combined with Fosphenytoin.
DB01323
The risk or severity of adverse effects can be increased when Temazepam is combined with St. John's Wort.
DB06594
The risk or severity of adverse effects can be increased when Temazepam is combined with Agomelatine.
DB06654
The risk or severity of adverse effects can be increased when Temazepam is combined with Safinamide.
DB09118
The risk or severity of adverse effects can be increased when Temazepam is combined with Stiripentol.
DB13384
The risk or severity of adverse effects can be increased when Temazepam is combined with Melitracen.
DB11951
The risk or severity of adverse effects can be increased when Temazepam is combined with Lemborexant.
DB01242
The risk or severity of adverse effects can be increased when Temazepam is combined with Clomipramine.
DB01356
The risk or severity of adverse effects can be increased when Temazepam is combined with Lithium cation.
DB08996
The risk or severity of adverse effects can be increased when Temazepam is combined with Dimetacrine.
DB12404
The risk or severity of adverse effects can be increased when Temazepam is combined with Remimazolam.
DB00751
The risk or severity of adverse effects can be increased when Temazepam is combined with Epinastine.
DB00230
The therapeutic efficacy of Temazepam can be increased when used in combination with Pregabalin.
DB09195
The risk or severity of sedation can be increased when Lorpiprazole is combined with Temazepam.
DB00150
The risk or severity of adverse effects can be increased when Tryptophan is combined with Temazepam.
DB00186
The risk or severity of adverse effects can be increased when Lorazepam is combined with Temazepam.
DB00206
The risk or severity of adverse effects can be increased when Reserpine is combined with Temazepam.
DB00234
The risk or severity of adverse effects can be increased when Temazepam is combined with Reboxetine.
DB00285
The risk or severity of adverse effects can be increased when Temazepam is combined with Venlafaxine.
DB00313
The risk or severity of adverse effects can be increased when Temazepam is combined with Valproic acid.
DB00334
The risk or severity of adverse effects can be increased when Temazepam is combined with Olanzapine.
DB00344
The risk or severity of adverse effects can be increased when Temazepam is combined with Protriptyline.
DB00349
The risk or severity of adverse effects can be increased when Temazepam is combined with Clobazam.
DB00371
The risk or severity of adverse effects can be increased when Temazepam is combined with Meprobamate.
DB00391
The risk or severity of adverse effects can be increased when Temazepam is combined with Sulpiride.
DB00404
The risk or severity of adverse effects can be increased when Temazepam is combined with Alprazolam.
DB00408
The risk or severity of adverse effects can be increased when Temazepam is combined with Loxapine.
DB00409
The risk or severity of adverse effects can be increased when Temazepam is combined with Remoxipride.
DB00420
The risk or severity of adverse effects can be increased when Temazepam is combined with Promazine.
DB00433
The risk or severity of adverse effects can be increased when Temazepam is combined with Prochlorperazine.
DB00475
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlordiazepoxide.
DB00477
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlorpromazine.
DB00508
The risk or severity of adverse effects can be increased when Temazepam is combined with Triflupromazine.
DB00540
The risk or severity of adverse effects can be increased when Temazepam is combined with Nortriptyline.
DB00543
The risk or severity of adverse effects can be increased when Temazepam is combined with Amoxapine.
DB00546
The risk or severity of adverse effects can be increased when Temazepam is combined with Adinazolam.
DB00555
The risk or severity of adverse effects can be increased when Temazepam is combined with Lamotrigine.
DB00623
The risk or severity of adverse effects can be increased when Temazepam is combined with Fluphenazine.
DB00628
The risk or severity of adverse effects can be increased when Temazepam is combined with Clorazepic acid.
DB00679
The risk or severity of adverse effects can be increased when Temazepam is combined with Thioridazine.
DB00683
The risk or severity of adverse effects can be increased when Temazepam is combined with Midazolam.
DB00690
The risk or severity of adverse effects can be increased when Temazepam is combined with Flurazepam.
DB00726
The risk or severity of adverse effects can be increased when Temazepam is combined with Trimipramine.
DB00734
The risk or severity of adverse effects can be increased when Temazepam is combined with Risperidone.
DB00752
The risk or severity of adverse effects can be increased when Temazepam is combined with Tranylcypromine.
DB00780
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenelzine.
DB00801
The risk or severity of adverse effects can be increased when Temazepam is combined with Halazepam.
DB00805
The risk or severity of adverse effects can be increased when Temazepam is combined with Minaprine.
DB00829
The risk or severity of adverse effects can be increased when Temazepam is combined with Diazepam.
DB00831
The risk or severity of adverse effects can be increased when Temazepam is combined with Trifluoperazine.
DB00837
The risk or severity of adverse effects can be increased when Temazepam is combined with Progabide.
DB00842
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxazepam.
DB00850
The risk or severity of adverse effects can be increased when Temazepam is combined with Perphenazine.
DB00875
The risk or severity of adverse effects can be increased when Temazepam is combined with Flupentixol.
DB00897
The risk or severity of adverse effects can be increased when Temazepam is combined with Triazolam.
DB00904
The risk or severity of adverse effects can be increased when Temazepam is combined with Ondansetron.
DB00933
The risk or severity of adverse effects can be increased when Temazepam is combined with Mesoridazine.
DB00934
The risk or severity of adverse effects can be increased when Temazepam is combined with Maprotiline.
DB00996
The risk or severity of adverse effects can be increased when Temazepam is combined with Gabapentin.
DB01037
The risk or severity of adverse effects can be increased when Temazepam is combined with Selegiline.
DB01100
The risk or severity of adverse effects can be increased when Temazepam is combined with Pimozide.
DB01156
The risk or severity of adverse effects can be increased when Temazepam is combined with Bupropion.
DB01171
The risk or severity of adverse effects can be increased when Temazepam is combined with Moclobemide.
DB01178
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlormezanone.
DB01215
The risk or severity of adverse effects can be increased when Temazepam is combined with Estazolam.
DB01224
The risk or severity of adverse effects can be increased when Temazepam is combined with Quetiapine.
DB01238
The risk or severity of adverse effects can be increased when Temazepam is combined with Aripiprazole.
DB01239
The risk or severity of adverse effects can be increased when Temazepam is combined with Chlorprothixene.
DB01247
The risk or severity of adverse effects can be increased when Temazepam is combined with Isocarboxazid.
DB01267
The risk or severity of adverse effects can be increased when Temazepam is combined with Paliperidone.
DB01445
The risk or severity of adverse effects can be increased when Temazepam is combined with Bufotenine.
DB01454
The risk or severity of adverse effects can be increased when Temazepam is combined with Midomafetamine.
DB01463
The risk or severity of adverse effects can be increased when Temazepam is combined with Fencamfamin.
DB01472
The risk or severity of adverse effects can be increased when Temazepam is combined with 4-Methoxyamphetamine.
DB01484
The risk or severity of adverse effects can be increased when Temazepam is combined with 4-Bromo-2,5-dimethoxyamphetamine.
DB01488
The risk or severity of adverse effects can be increased when Temazepam is combined with Dimethyltryptamine.
DB01509
The risk or severity of adverse effects can be increased when Temazepam is combined with Tenamfetamine.
DB01544
The risk or severity of adverse effects can be increased when Temazepam is combined with Flunitrazepam.
DB01545
The risk or severity of adverse effects can be increased when Temazepam is combined with Ethyl loflazepate.
DB01558
The risk or severity of adverse effects can be increased when Temazepam is combined with Bromazepam.
DB01560
The risk or severity of adverse effects can be increased when Temazepam is combined with Cathinone.
DB01567
The risk or severity of adverse effects can be increased when Temazepam is combined with Fludiazepam.
DB01587
The risk or severity of adverse effects can be increased when Temazepam is combined with Ketazolam.
DB01588
The risk or severity of adverse effects can be increased when Temazepam is combined with Prazepam.
DB01595
The risk or severity of adverse effects can be increased when Temazepam is combined with Nitrazepam.
DB01614
The risk or severity of adverse effects can be increased when Temazepam is combined with Acepromazine.
DB01615
The risk or severity of adverse effects can be increased when Temazepam is combined with Aceprometazine.
DB01618
The risk or severity of adverse effects can be increased when Temazepam is combined with Molindone.
DB01623
The risk or severity of adverse effects can be increased when Temazepam is combined with Thiothixene.
DB01624
The risk or severity of adverse effects can be increased when Temazepam is combined with Zuclopenthixol.
DB01954
The risk or severity of adverse effects can be increased when Temazepam is combined with Rolipram.
DB02207
The risk or severity of adverse effects can be increased when Temazepam is combined with 7-Nitroindazole.
DB02959
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxitriptan.
DB03575
The risk or severity of adverse effects can be increased when Temazepam is combined with Phencyclidine.
DB04017
The risk or severity of adverse effects can be increased when Temazepam is combined with Clorgiline.
DB04325
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenethylamine.
DB04599
The risk or severity of adverse effects can be increased when Temazepam is combined with Aniracetam.
DB04818
The risk or severity of adverse effects can be increased when Temazepam is combined with Iproniazid.
DB04820
The risk or severity of adverse effects can be increased when Temazepam is combined with Nialamide.
DB04829
The risk or severity of adverse effects can be increased when Temazepam is combined with Lysergic acid diethylamide.
DB04836
The risk or severity of adverse effects can be increased when Temazepam is combined with Amineptine.
DB04842
The risk or severity of adverse effects can be increased when Temazepam is combined with Fluspirilene.
DB04872
The risk or severity of adverse effects can be increased when Temazepam is combined with Osanetant.
DB04946
The risk or severity of adverse effects can be increased when Temazepam is combined with Iloperidone.
DB05316
The risk or severity of adverse effects can be increased when Temazepam is combined with Pimavanserin.
DB06016
The risk or severity of adverse effects can be increased when Temazepam is combined with Cariprazine.
DB06144
The risk or severity of adverse effects can be increased when Temazepam is combined with Sertindole.
DB06148
The risk or severity of adverse effects can be increased when Temazepam is combined with Mianserin.
DB06153
The risk or severity of adverse effects can be increased when Temazepam is combined with Pizotifen.
DB06216
The risk or severity of adverse effects can be increased when Temazepam is combined with Asenapine.
DB06288
The risk or severity of adverse effects can be increased when Temazepam is combined with Amisulpride.
DB06512
The risk or severity of adverse effects can be increased when Temazepam is combined with Deramciclane.
DB06579
The risk or severity of adverse effects can be increased when Temazepam is combined with Adipiplon.
DB06582
The risk or severity of adverse effects can be increased when Temazepam is combined with Dextofisopam.
DB06678
The risk or severity of adverse effects can be increased when Temazepam is combined with Esmirtazapine.
DB06684
The risk or severity of adverse effects can be increased when Temazepam is combined with Vilazodone.
DB08811
The risk or severity of adverse effects can be increased when Temazepam is combined with Tofisopam.
DB08815
The risk or severity of adverse effects can be increased when Temazepam is combined with Lurasidone.
DB08922
The risk or severity of adverse effects can be increased when Temazepam is combined with Perospirone.
DB08927
The risk or severity of adverse effects can be increased when Temazepam is combined with Amperozide.
DB08986
The risk or severity of adverse effects can be increased when Temazepam is combined with Etifoxine.
DB09016
The risk or severity of adverse effects can be increased when Temazepam is combined with Butriptyline.
DB09023
The risk or severity of adverse effects can be increased when Temazepam is combined with Benactyzine.
DB09068
The risk or severity of adverse effects can be increased when Temazepam is combined with Vortioxetine.
DB09166
The risk or severity of adverse effects can be increased when Temazepam is combined with Etizolam.
DB09167
The risk or severity of adverse effects can be increased when Temazepam is combined with Dosulepin.
DB09185
The risk or severity of adverse effects can be increased when Temazepam is combined with Viloxazine.
DB09224
The risk or severity of adverse effects can be increased when Temazepam is combined with Melperone.
DB09225
The risk or severity of adverse effects can be increased when Temazepam is combined with Zotepine.
DB09226
The risk or severity of adverse effects can be increased when Temazepam is combined with Brilaroxazine.
DB09244
The risk or severity of adverse effects can be increased when Temazepam is combined with Pirlindole.
DB09245
The risk or severity of adverse effects can be increased when Temazepam is combined with Toloxatone.
DB09286
The risk or severity of adverse effects can be increased when Temazepam is combined with Pipamperone.
DB09289
The risk or severity of adverse effects can be increased when Temazepam is combined with Tianeptine.
DB09307
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxaprotiline.
DB11376
The risk or severity of adverse effects can be increased when Temazepam is combined with Azaperone.
DB11555
The risk or severity of adverse effects can be increased when Temazepam is combined with Zolazepam.
DB11664
The risk or severity of adverse effects can be increased when Temazepam is combined with Psilocybin.
DB12093
The risk or severity of adverse effects can be increased when Temazepam is combined with Tetrahydropalmatine.
DB12184
The risk or severity of adverse effects can be increased when Temazepam is combined with Gepirone.
DB12273
The risk or severity of adverse effects can be increased when Temazepam is combined with Ecopipam.
DB12327
The risk or severity of adverse effects can be increased when Temazepam is combined with Salvinorin A.
DB12401
The risk or severity of adverse effects can be increased when Temazepam is combined with Bromperidol.
DB12518
The risk or severity of adverse effects can be increased when Temazepam is combined with Raclopride.
DB12710
The risk or severity of adverse effects can be increased when Temazepam is combined with Perazine.
DB12833
The risk or severity of adverse effects can be increased when Temazepam is combined with Tandospirone.
DB12867
The risk or severity of adverse effects can be increased when Temazepam is combined with Benperidol.
DB12930
The risk or severity of adverse effects can be increased when Temazepam is combined with Opipramol.
DB13014
The risk or severity of adverse effects can be increased when Temazepam is combined with Hypericin.
DB13025
The risk or severity of adverse effects can be increased when Temazepam is combined with Tiapride.
DB13082
The risk or severity of adverse effects can be increased when Temazepam is combined with Nefiracetam.
DB13225
The risk or severity of adverse effects can be increased when Temazepam is combined with Dibenzepin.
DB13256
The risk or severity of adverse effects can be increased when Temazepam is combined with Clothiapine.
DB13273
The risk or severity of adverse effects can be increased when Temazepam is combined with Sultopride.
DB13335
The risk or severity of adverse effects can be increased when Temazepam is combined with Pinazepam.
DB13352
The risk or severity of adverse effects can be increased when Temazepam is combined with Deanol.
DB13411
The risk or severity of adverse effects can be increased when Temazepam is combined with Lofepramine.
DB13437
The risk or severity of adverse effects can be increased when Temazepam is combined with Medazepam.
DB13455
The risk or severity of adverse effects can be increased when Temazepam is combined with Phenibut.
DB13496
The risk or severity of adverse effects can be increased when Temazepam is combined with Iprindole.
DB13522
The risk or severity of adverse effects can be increased when Temazepam is combined with Mebicar.
DB13523
The risk or severity of adverse effects can be increased when Temazepam is combined with Veralipride.
DB13550
The risk or severity of adverse effects can be increased when Temazepam is combined with Bifemelane.
DB13552
The risk or severity of adverse effects can be increased when Temazepam is combined with Trifluperidol.
DB13601
The risk or severity of adverse effects can be increased when Temazepam is combined with Oxiracetam.
DB13643
The risk or severity of adverse effects can be increased when Temazepam is combined with Loprazolam.
DB13665
The risk or severity of adverse effects can be increased when Temazepam is combined with Fluanisone.
DB13784
The risk or severity of adverse effects can be increased when Temazepam is combined with Dixyrazine.
DB13791
The risk or severity of adverse effects can be increased when Temazepam is combined with Penfluridol.
DB13841
The risk or severity of adverse effects can be increased when Temazepam is combined with Clopenthixol.
DB14028
The risk or severity of adverse effects can be increased when Temazepam is combined with Nordazepam.
DB14185
The risk or severity of adverse effects can be increased when Temazepam is combined with Aripiprazole lauroxil.
DB04844
The risk or severity of sedation and somnolence can be increased when Temazepam is combined with Tetrabenazine.
DB12161
The risk or severity of sedation and somnolence can be increased when Temazepam is combined with Deutetrabenazine.
DB04948
The therapeutic efficacy of Temazepam can be increased when used in combination with Lofexidine.
DB00159
Icosapent may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00229
Cefotiam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00244
Mesalazine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00267
Cefmenoxime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00274
Cefmetazole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00282
Pamidronic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00300
Tenofovir disoproxil may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00328
Indomethacin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00369
Cidofovir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00384
Triamterene may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00430
Cefpiramide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00438
Ceftazidime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00447
Loracarbef may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00456
Cefalotin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00461
Nabumetone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00465
Ketorolac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00469
Tenoxicam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00493
Cefotaxime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00500
Tolmetin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00529
Foscarnet may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00533
Rofecoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00554
Piroxicam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00563
Methotrexate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00567
Cephalexin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00573
Fenoprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00577
Valaciclovir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00580
Valdecoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00586
Diclofenac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00605
Sulindac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00626
Bacitracin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00681
Amphotericin B may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00689
Cephaloglycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00712
Flurbiprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00718
Adefovir dipivoxil may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00738
Pentamidine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00742
Mannitol may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00749
Etodolac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00787
Acyclovir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00788
Naproxen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00795
Sulfasalazine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00812
Phenylbutazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00814
Meloxicam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00821
Carprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00833
Cefaclor may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00861
Diflunisal may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00903
Etacrynic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00923
Ceforanide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00936
Salicylic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00939
Meclofenamic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00945
Acetylsalicylic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00958
Carboplatin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00991
Oxaprozin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00999
Hydrochlorothiazide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01009
Ketoprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01014
Balsalazide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01066
Cefditoren may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01111
Colistimethate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01112
Cefuroxime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01139
Cefapirin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01140
Cefadroxil may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01150
Cefprozil may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01212
Ceftriaxone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01250
Olsalazine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01283
Lumiracoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01326
Cefamandole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01327
Cefazolin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01328
Cefonicid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01329
Cefoperazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01330
Cefotetan may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01331
Cefoxitin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01332
Ceftizoxime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01333
Cefradine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01397
Magnesium salicylate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01399
Salsalate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01401
Choline magnesium trisalicylate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01413
Cefepime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01414
Cefacetrile may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01415
Ceftibuten may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01416
Cefpodoxime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01419
Antrafenine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01424
Aminophenazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01435
Antipyrine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01600
Tiaprofenic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01628
Etoricoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB02247
Hydrolyzed Cephalothin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB03450
Cephalothin Group may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB03585
Oxyphenbutazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04570
Latamoxef may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04743
Nimesulide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04812
Benoxaprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04817
Metamizole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04828
Zomepirac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04918
Ceftobiprole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB05095
Cimicoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB06590
Ceftaroline fosamil may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB06725
Lornoxicam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB06736
Aceclofenac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB06737
Zaltoprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB07402
Azapropazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08439
Parecoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08797
Salicylamide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08940
Kebuzone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08942
Isoxicam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08951
Indoprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08955
Ibuproxam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08976
Floctafenine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08981
Fenbufen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08984
Etofenamate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08991
Epirizole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09008
Cefaloridine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09062
Cefminox may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09084
Benzydamine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09213
Dexibuprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09215
Droxicam may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09216
Tolfenamic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09217
Firocoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09218
Clonixin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09285
Morniflumate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09288
Propacetamol may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09295
Talniflumate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09299
Tenofovir alafenamide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11367
Cefroxadine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11455
Robenacoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11466
Tepoxalin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11518
Flunixin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11935
Flomoxef may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB12151
Brincidofovir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB12445
Nitroaspirin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB12545
Indobufen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13001
Tinoridine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13167
Alclofenac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13217
Fentiazac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13232
Suxibuzone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13266
Cefatrizine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13286
Bumadizone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13314
Alminoprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13371
Difenpiramide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13407
Nifenazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13432
Lonazolac may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13461
Cefcapene may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13470
Cefodizime may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13481
Tenidap may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13499
Cefsulodin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13504
Cefetamet may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13524
Propyphenazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13527
Proglumetacin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13538
Guacetisal may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13544
Ethenzamide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13612
Carbaspirin calcium may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13629
Mofebutazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13638
Cefbuperazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13649
Proquazone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13657
Benorilate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13667
Cefozopran may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13682
Cefpirome may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13722
Pirprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13778
Cefazedone may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13783
Acemetacin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13821
Ceftezole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13860
Imidazole salicylate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13868
Adefovir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB14059
SC-236 may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB14060
NS-398 may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB14126
Tenofovir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB14713
Inotersen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01438
Phenazopyridine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09214
Dexketoprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00091
Cyclosporine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00482
Celecoxib may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00784
Mefenamic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00864
Tacrolimus may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01050
Ibuprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01072
Atazanavir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01601
Lopinavir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB15066
Givosiran may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB14507
Lithium citrate may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB09212
Loxoprofen may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00452
Framycetin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01421
Paromomycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04263
Geneticin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04626
Apramycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04808
Neamine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB08437
Puromycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11512
Dihydrostreptomycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB11520
Hygromycin B may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00007
Leuprolide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00014
Goserelin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00017
Salmon calcitonin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00035
Desmopressin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00041
Aldesleukin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00080
Daptomycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00081
Tositumomab may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00115
Cyanocobalamin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00158
Folic acid may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00165
Pyridoxine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00185
Cevimeline may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00190
Carbidopa may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00198
Oseltamivir may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00200
Hydroxocobalamin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00213
Pantoprazole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00225
Gadodiamide may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00235
Temazepam may decrease the excretion rate of Milrinone which could result in a higher serum level.
DB00243
Temazepam may decrease the excretion rate of Ranolazine which could result in a higher serum level.
DB00254
Temazepam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
DB00262
Temazepam may decrease the excretion rate of Carmustine which could result in a higher serum level.
DB00264
Temazepam may decrease the excretion rate of Metoprolol which could result in a higher serum level.
DB00270
Temazepam may decrease the excretion rate of Isradipine which could result in a higher serum level.
DB00271
Temazepam may decrease the excretion rate of Diatrizoate which could result in a higher serum level.
DB00279
Temazepam may decrease the excretion rate of Liothyronine which could result in a higher serum level.
DB00284
Temazepam may decrease the excretion rate of Acarbose which could result in a higher serum level.
DB00286
Temazepam may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
DB00290
Temazepam may decrease the excretion rate of Bleomycin which could result in a higher serum level.
DB00294
Temazepam may decrease the excretion rate of Etonogestrel which could result in a higher serum level.
DB00303
Temazepam may decrease the excretion rate of Ertapenem which could result in a higher serum level.
DB00308
Temazepam may decrease the excretion rate of Ibutilide which could result in a higher serum level.
DB00316
Temazepam may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
DB00319
Temazepam may decrease the excretion rate of Piperacillin which could result in a higher serum level.
DB00325
Temazepam may decrease the excretion rate of Nitroprusside which could result in a higher serum level.
DB00330
Temazepam may decrease the excretion rate of Ethambutol which could result in a higher serum level.
DB00331
Temazepam may decrease the excretion rate of Metformin which could result in a higher serum level.
DB00339
Temazepam may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
DB00351
Temazepam may decrease the excretion rate of Megestrol acetate which could result in a higher serum level.
DB00355
Temazepam may decrease the excretion rate of Aztreonam which could result in a higher serum level.
DB00364
Temazepam may decrease the excretion rate of Sucralfate which could result in a higher serum level.
DB00373
Temazepam may decrease the excretion rate of Timolol which could result in a higher serum level.
DB00380
Temazepam may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
DB00415
Temazepam may decrease the excretion rate of Ampicillin which could result in a higher serum level.
DB00422
Temazepam may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
DB00432
Temazepam may decrease the excretion rate of Trifluridine which could result in a higher serum level.
DB00435
Temazepam may decrease the excretion rate of Nitric Oxide which could result in a higher serum level.
DB00437
Temazepam may decrease the excretion rate of Allopurinol which could result in a higher serum level.
DB00441
Temazepam may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
DB00480
Temazepam may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
DB00492
Temazepam may decrease the excretion rate of Fosinopril which could result in a higher serum level.
DB00499
Temazepam may decrease the excretion rate of Flutamide which could result in a higher serum level.
DB00535
Temazepam may decrease the excretion rate of Cefdinir which could result in a higher serum level.
DB00537
Temazepam may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
DB00548
Temazepam may decrease the excretion rate of Azelaic acid which could result in a higher serum level.
DB00553
Temazepam may decrease the excretion rate of Methoxsalen which could result in a higher serum level.
DB00558
Temazepam may decrease the excretion rate of Zanamivir which could result in a higher serum level.
DB00569
Temazepam may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
DB00571
Temazepam may decrease the excretion rate of Propranolol which could result in a higher serum level.
DB00583
Temazepam may decrease the excretion rate of Levocarnitine which could result in a higher serum level.
DB00591
Temazepam may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level.
DB00597
Temazepam may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
DB00598
Temazepam may decrease the excretion rate of Labetalol which could result in a higher serum level.
DB00612
Temazepam may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
DB00624
Temazepam may decrease the excretion rate of Testosterone which could result in a higher serum level.
DB00631
Temazepam may decrease the excretion rate of Clofarabine which could result in a higher serum level.
DB00635
Temazepam may decrease the excretion rate of Prednisone which could result in a higher serum level.
DB00657
Temazepam may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
DB00672
Temazepam may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
DB00692
Temazepam may decrease the excretion rate of Phentolamine which could result in a higher serum level.
DB00698
Temazepam may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
DB00706
Temazepam may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
DB00709
Temazepam may decrease the excretion rate of Lamivudine which could result in a higher serum level.
DB00713
Temazepam may decrease the excretion rate of Oxacillin which could result in a higher serum level.
DB00716
Temazepam may decrease the excretion rate of Nedocromil which could result in a higher serum level.
DB00722
Temazepam may decrease the excretion rate of Lisinopril which could result in a higher serum level.
DB00730
Temazepam may decrease the excretion rate of Thiabendazole which could result in a higher serum level.
DB00731
Temazepam may decrease the excretion rate of Nateglinide which could result in a higher serum level.
DB00733
Temazepam may decrease the excretion rate of Pralidoxime which could result in a higher serum level.
DB00743
Temazepam may decrease the excretion rate of Gadobenic acid which could result in a higher serum level.
DB00759
Temazepam may decrease the excretion rate of Tetracycline which could result in a higher serum level.
DB00760
Temazepam may decrease the excretion rate of Meropenem which could result in a higher serum level.
DB00761
Temazepam may decrease the excretion rate of Potassium chloride which could result in a higher serum level.
DB00775
Temazepam may decrease the excretion rate of Tirofiban which could result in a higher serum level.
DB00783
Temazepam may decrease the excretion rate of Estradiol which could result in a higher serum level.
DB00789
Temazepam may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
DB00790
Temazepam may decrease the excretion rate of Perindopril which could result in a higher serum level.
DB00800
Temazepam may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
DB00811
Temazepam may decrease the excretion rate of Ribavirin which could result in a higher serum level.
DB00828
Temazepam may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
DB00839
Temazepam may decrease the excretion rate of Tolazamide which could result in a higher serum level.
DB00841
Temazepam may decrease the excretion rate of Dobutamine which could result in a higher serum level.
DB00851
Temazepam may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
DB00853
Temazepam may decrease the excretion rate of Temozolomide which could result in a higher serum level.
DB00863
Temazepam may decrease the excretion rate of Ranitidine which could result in a higher serum level.
DB00871
Temazepam may decrease the excretion rate of Terbutaline which could result in a higher serum level.
DB00894
Temazepam may decrease the excretion rate of Testolactone which could result in a higher serum level.
DB00900
Temazepam may decrease the excretion rate of Didanosine which could result in a higher serum level.
DB00911
Temazepam may decrease the excretion rate of Tinidazole which could result in a higher serum level.
DB00915
Temazepam may decrease the excretion rate of Amantadine which could result in a higher serum level.
DB00928
Temazepam may decrease the excretion rate of Azacitidine which could result in a higher serum level.
DB00961
Temazepam may decrease the excretion rate of Mepivacaine which could result in a higher serum level.
DB00968
Temazepam may decrease the excretion rate of Methyldopa which could result in a higher serum level.
DB00988
Temazepam may decrease the excretion rate of Dopamine which could result in a higher serum level.
DB00993
Temazepam may decrease the excretion rate of Azathioprine which could result in a higher serum level.
DB00995
Temazepam may decrease the excretion rate of Auranofin which could result in a higher serum level.
DB01001
Temazepam may decrease the excretion rate of Salbutamol which could result in a higher serum level.
DB01002
Temazepam may decrease the excretion rate of Levobupivacaine which could result in a higher serum level.
DB01004
Temazepam may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
DB01010
Temazepam may decrease the excretion rate of Edrophonium which could result in a higher serum level.
DB01011
Temazepam may decrease the excretion rate of Metyrapone which could result in a higher serum level.
DB01020
Temazepam may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level.
DB01022
Temazepam may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
DB01024
Temazepam may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
DB01030
Temazepam may decrease the excretion rate of Topotecan which could result in a higher serum level.
DB01032
Temazepam may decrease the excretion rate of Probenecid which could result in a higher serum level.
DB01046
Temazepam may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
DB01048
Temazepam may decrease the excretion rate of Abacavir which could result in a higher serum level.
DB01060
Temazepam may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
DB01067
Temazepam may decrease the excretion rate of Glipizide which could result in a higher serum level.
DB01093
Temazepam may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level.
DB01099
Temazepam may decrease the excretion rate of Flucytosine which could result in a higher serum level.
DB01133
Temazepam may decrease the excretion rate of Tiludronic acid which could result in a higher serum level.
DB01137
Temazepam may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
DB01157
Temazepam may decrease the excretion rate of Trimetrexate which could result in a higher serum level.
DB01166
Temazepam may decrease the excretion rate of Cilostazol which could result in a higher serum level.
DB01169
Temazepam may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
DB01170
Temazepam may decrease the excretion rate of Guanethidine which could result in a higher serum level.
DB01181
Temazepam may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
DB01203
Temazepam may decrease the excretion rate of Nadolol which could result in a higher serum level.
DB01213
Temazepam may decrease the excretion rate of Fomepizole which could result in a higher serum level.
DB01240
Temazepam may decrease the excretion rate of Epoprostenol which could result in a higher serum level.
DB01249
Temazepam may decrease the excretion rate of Iodixanol which could result in a higher serum level.
DB01273
Temazepam may decrease the excretion rate of Varenicline which could result in a higher serum level.
DB01274
Temazepam may decrease the excretion rate of Arformoterol which could result in a higher serum level.
DB01275
Temazepam may decrease the excretion rate of Hydralazine which could result in a higher serum level.
DB01420
Temazepam may decrease the excretion rate of Testosterone propionate which could result in a higher serum level.
DB01427
Temazepam may decrease the excretion rate of Amrinone which could result in a higher serum level.
DB01428
Temazepam may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
DB01431
Temazepam may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
DB01550
Temazepam may decrease the excretion rate of Fenproporex which could result in a higher serum level.
DB01610
Temazepam may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
DB01638
Temazepam may decrease the excretion rate of Sorbitol which could result in a higher serum level.
DB01656
Temazepam may decrease the excretion rate of Roflumilast which could result in a higher serum level.
DB04895
Temazepam may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
DB04920
Temazepam may decrease the excretion rate of Clevidipine which could result in a higher serum level.
DB05018
Temazepam may decrease the excretion rate of Migalastat which could result in a higher serum level.
DB06154
Temazepam may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level.
DB06186
Temazepam may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
DB06196
Temazepam may decrease the excretion rate of Icatibant which could result in a higher serum level.
DB06203
Temazepam may decrease the excretion rate of Alogliptin which could result in a higher serum level.
DB06211
Temazepam may decrease the excretion rate of Doripenem which could result in a higher serum level.
DB06230
Temazepam may decrease the excretion rate of Nalmefene which could result in a higher serum level.
DB06262
Temazepam may decrease the excretion rate of Droxidopa which could result in a higher serum level.
DB06335
Temazepam may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
DB06402
Temazepam may decrease the excretion rate of Telavancin which could result in a higher serum level.
DB06480
Temazepam may decrease the excretion rate of Prucalopride which could result in a higher serum level.
DB06623
Temazepam may decrease the excretion rate of Flupirtine which could result in a higher serum level.
DB06637
Temazepam may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
DB06695
Temazepam may decrease the excretion rate of Dabigatran etexilate which could result in a higher serum level.
DB06705
Temazepam may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
DB06767
Temazepam may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
DB06782
Temazepam may decrease the excretion rate of Dimercaprol which could result in a higher serum level.
DB06796
Temazepam may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
DB06800
Temazepam may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
DB06809
Temazepam may decrease the excretion rate of Plerixafor which could result in a higher serum level.
DB06813
Temazepam may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
DB06823
Temazepam may decrease the excretion rate of Tiopronin which could result in a higher serum level.
DB06824
Temazepam may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level.
DB08824
Temazepam may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
DB08826
Temazepam may decrease the excretion rate of Deferiprone which could result in a higher serum level.
DB08840
Temazepam may decrease the excretion rate of N-methylnicotinamide which could result in a higher serum level.
DB08877
Temazepam may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
DB08893
Temazepam may decrease the excretion rate of Mirabegron which could result in a higher serum level.
DB08894
Temazepam may decrease the excretion rate of Peginesatide which could result in a higher serum level.
DB08905
Temazepam may decrease the excretion rate of Formestane which could result in a higher serum level.
DB08909
Temazepam may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level.
DB08932
Temazepam may decrease the excretion rate of Macitentan which could result in a higher serum level.
DB08934
Temazepam may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
DB09027
Temazepam may decrease the excretion rate of Ledipasvir which could result in a higher serum level.
DB09050
Temazepam may decrease the excretion rate of Ceftolozane which could result in a higher serum level.
DB09066
Temazepam may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level.
DB09075
Temazepam may decrease the excretion rate of Edoxaban which could result in a higher serum level.
DB09081
Temazepam may decrease the excretion rate of Idebenone which could result in a higher serum level.
DB09082
Temazepam may decrease the excretion rate of Vilanterol which could result in a higher serum level.
DB09091
Temazepam may decrease the excretion rate of Tixocortol which could result in a higher serum level.
DB09103
Temazepam may decrease the excretion rate of Ancestim which could result in a higher serum level.
DB09104
Temazepam may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
DB09106
Temazepam may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
DB09111
Temazepam may decrease the excretion rate of Pentastarch which could result in a higher serum level.
DB09121
Temazepam may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.
DB09123
Temazepam may decrease the excretion rate of Dienogest which could result in a higher serum level.
DB09129
Temazepam may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
DB09132
Temazepam may decrease the excretion rate of Gadoteric acid which could result in a higher serum level.
DB09133
Temazepam may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.
DB09134
Temazepam may decrease the excretion rate of Ioversol which could result in a higher serum level.
DB09135
Temazepam may decrease the excretion rate of Ioxilan which could result in a higher serum level.
DB09136
Temazepam may decrease the excretion rate of Isosulfan blue which could result in a higher serum level.
DB09137
Temazepam may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
DB09139
Temazepam may decrease the excretion rate of Technetium Tc-99m oxidronate which could result in a higher serum level.
DB09148
Temazepam may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level.
DB09149
Temazepam may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level.
DB09156
Temazepam may decrease the excretion rate of Iopromide which could result in a higher serum level.
DB09163
Temazepam may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level.
DB09165
Temazepam may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level.
DB09204
Temazepam may decrease the excretion rate of Arotinolol which could result in a higher serum level.
DB09205
Temazepam may decrease the excretion rate of Moxisylyte which could result in a higher serum level.
DB09209
Temazepam may decrease the excretion rate of Pholcodine which could result in a higher serum level.
DB09210
Temazepam may decrease the excretion rate of Piracetam which could result in a higher serum level.
DB09219
Temazepam may decrease the excretion rate of Bisoxatin which could result in a higher serum level.
DB09220
Temazepam may decrease the excretion rate of Nicorandil which could result in a higher serum level.
DB09255
Temazepam may decrease the excretion rate of Dextran which could result in a higher serum level.
DB09257
Temazepam may decrease the excretion rate of Gimeracil which could result in a higher serum level.
DB09264
Temazepam may decrease the excretion rate of Idarucizumab which could result in a higher serum level.
DB09265
Temazepam may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
DB09268
Temazepam may decrease the excretion rate of Picosulfuric acid which could result in a higher serum level.
DB09276
Temazepam may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
DB09277
Temazepam may decrease the excretion rate of Choline C 11 which could result in a higher serum level.
DB09281
Temazepam may decrease the excretion rate of Magnesium trisilicate which could result in a higher serum level.
DB09292
Temazepam may decrease the excretion rate of Sacubitril which could result in a higher serum level.
DB09301
Temazepam may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level.
DB09317
Temazepam may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level.
DB09318
Temazepam may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level.
DB09320
Temazepam may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
DB09324
Temazepam may decrease the excretion rate of Sulbactam which could result in a higher serum level.
DB09325
Temazepam may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
DB09329
Temazepam may decrease the excretion rate of Antihemophilic Factor (Recombinant), PEGylated which could result in a higher serum level.
DB09344
Temazepam may decrease the excretion rate of Invert sugar which could result in a higher serum level.
DB09357
Temazepam may decrease the excretion rate of Dexpanthenol which could result in a higher serum level.
DB09394
Temazepam may decrease the excretion rate of Phosphoric acid which could result in a higher serum level.
DB09395
Temazepam may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
DB09407
Temazepam may decrease the excretion rate of Magnesium chloride which could result in a higher serum level.
DB09418
Temazepam may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level.
DB09472
Temazepam may decrease the excretion rate of Sodium sulfate which could result in a higher serum level.
DB09477
Temazepam may decrease the excretion rate of Enalaprilat which could result in a higher serum level.
DB09481
Temazepam may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
DB09488
Temazepam may decrease the excretion rate of Acrivastine which could result in a higher serum level.
DB09496
Temazepam may decrease the excretion rate of Octinoxate which could result in a higher serum level.
DB09502
Temazepam may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
DB09546
Temazepam may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level.
DB11077
Temazepam may decrease the excretion rate of Polyethylene glycol 400 which could result in a higher serum level.
DB11090
Temazepam may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
DB11098
Temazepam may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
DB11102
Temazepam may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
DB11114
Temazepam may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
DB11127
Temazepam may decrease the excretion rate of Selenious acid which could result in a higher serum level.
DB11135
Temazepam may decrease the excretion rate of Selenium which could result in a higher serum level.
DB11136
Temazepam may decrease the excretion rate of Chromium which could result in a higher serum level.
DB11145
Temazepam may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
DB11164
Temazepam may decrease the excretion rate of Bicisate which could result in a higher serum level.
DB11251
Temazepam may decrease the excretion rate of Tocopherol which could result in a higher serum level.
DB11278
Temazepam may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level.
DB11328
Temazepam may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
DB11338
Temazepam may decrease the excretion rate of Clove oil which could result in a higher serum level.
DB11358
Temazepam may decrease the excretion rate of Evening primrose oil which could result in a higher serum level.
DB11364
Temazepam may decrease the excretion rate of Pidotimod which could result in a higher serum level.
DB11560
Temazepam may decrease the excretion rate of Lesinurad which could result in a higher serum level.
DB11577
Temazepam may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level.
DB11587
Temazepam may decrease the excretion rate of Etafedrine which could result in a higher serum level.
DB11598
Temazepam may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
DB11691
Temazepam may decrease the excretion rate of Naldemedine which could result in a higher serum level.
DB11817
Temazepam may decrease the excretion rate of Baricitinib which could result in a higher serum level.
DB11915
Temazepam may decrease the excretion rate of Valbenazine which could result in a higher serum level.
DB11943
Temazepam may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
DB11989
Temazepam may decrease the excretion rate of Benznidazole which could result in a higher serum level.
DB12007
Temazepam may decrease the excretion rate of Isoflavone which could result in a higher serum level.
DB12107
Temazepam may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
DB12783
Temazepam may decrease the excretion rate of Benserazide which could result in a higher serum level.
DB13139
Temazepam may decrease the excretion rate of Levosalbutamol which could result in a higher serum level.
DB13156
Temazepam may decrease the excretion rate of Inosine pranobex which could result in a higher serum level.
DB13178
Temazepam may decrease the excretion rate of Inositol which could result in a higher serum level.
DB13185
Temazepam may decrease the excretion rate of Oxabolone cipionate which could result in a higher serum level.
DB13191
Temazepam may decrease the excretion rate of Phosphocreatine which could result in a higher serum level.
DB13269
Temazepam may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
DB13293
Temazepam may decrease the excretion rate of Ipecac which could result in a higher serum level.
DB13595
Temazepam may decrease the excretion rate of Almasilate which could result in a higher serum level.
DB13873
Temazepam may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
DB13884
Temazepam may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
DB13909
Temazepam may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
DB13943
Temazepam may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
DB13944
Temazepam may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.
DB13946
Temazepam may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level.
DB13952
Temazepam may decrease the excretion rate of Estradiol acetate which could result in a higher serum level.
DB13954
Temazepam may decrease the excretion rate of Estradiol cypionate which could result in a higher serum level.
DB13955
Temazepam may decrease the excretion rate of Estradiol dienanthate which could result in a higher serum level.
DB13956
Temazepam may decrease the excretion rate of Estradiol valerate which could result in a higher serum level.
DB13967
Temazepam may decrease the excretion rate of Patent Blue which could result in a higher serum level.
DB14006
Temazepam may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
DB14007
Temazepam may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
DB14498
Temazepam may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
DB14499
Temazepam may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
DB14526
Temazepam may decrease the excretion rate of Chromic citrate which could result in a higher serum level.
DB14527
Temazepam may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
DB14528
Temazepam may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
DB14529
Temazepam may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.
DB14530
Temazepam may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
DB06815
Temazepam may decrease the excretion rate of Pyrithione which could result in a higher serum level.
DB11121
Temazepam may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
DB00196
Fluconazole may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00208
Ticlopidine may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00296
Temazepam may decrease the excretion rate of Ropivacaine which could result in a higher serum level.
DB00322
Temazepam may decrease the excretion rate of Floxuridine which could result in a higher serum level.
DB00359
Temazepam may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
DB00398
Temazepam may decrease the excretion rate of Sorafenib which could result in a higher serum level.
DB00401
Temazepam may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
DB00412
Temazepam may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
DB00440
Temazepam may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
DB00490
Temazepam may decrease the excretion rate of Buspirone which could result in a higher serum level.
DB00501
Temazepam may decrease the excretion rate of Cimetidine which could result in a higher serum level.
DB00603
Temazepam may decrease the excretion rate of Medroxyprogesterone acetate which could result in a higher serum level.
DB00608
Temazepam may decrease the excretion rate of Chloroquine which could result in a higher serum level.
DB00661
Temazepam may decrease the excretion rate of Verapamil which could result in a higher serum level.
DB00665
Temazepam may decrease the excretion rate of Nilutamide which could result in a higher serum level.
DB00688
Temazepam may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
DB00763
Temazepam may decrease the excretion rate of Methimazole which could result in a higher serum level.
DB00820
Temazepam may decrease the excretion rate of Tadalafil which could result in a higher serum level.
DB00951
Temazepam may decrease the excretion rate of Isoniazid which could result in a higher serum level.
DB01015
Temazepam may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
DB01039
Temazepam may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
DB01043
Temazepam may decrease the excretion rate of Memantine which could result in a higher serum level.
DB01101
Temazepam may decrease the excretion rate of Capecitabine which could result in a higher serum level.
DB01115
Temazepam may decrease the excretion rate of Nifedipine which could result in a higher serum level.
DB01124
Temazepam may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
DB01129
Temazepam may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
DB01183
Temazepam may decrease the excretion rate of Naloxone which could result in a higher serum level.
DB01222
Temazepam may decrease the excretion rate of Budesonide which could result in a higher serum level.
DB01241
Temazepam may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
DB01261
Temazepam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
DB01394
Temazepam may decrease the excretion rate of Colchicine which could result in a higher serum level.
DB01685
Temazepam may decrease the excretion rate of Topiroxostat which could result in a higher serum level.
DB04574
Temazepam may decrease the excretion rate of Estrone sulfate which could result in a higher serum level.
DB05676
Temazepam may decrease the excretion rate of Apremilast which could result in a higher serum level.
DB06209
Temazepam may decrease the excretion rate of Prasugrel which could result in a higher serum level.
DB06228
Temazepam may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
DB06710
Temazepam may decrease the excretion rate of Methyltestosterone which could result in a higher serum level.
DB08899
Temazepam may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
DB08904
Temazepam may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
DB08911
Temazepam may decrease the excretion rate of Trametinib which could result in a higher serum level.
DB09256
Temazepam may decrease the excretion rate of Tegafur which could result in a higher serum level.
DB09570
Temazepam may decrease the excretion rate of Ixazomib which could result in a higher serum level.
DB11085
Temazepam may decrease the excretion rate of Resorcinol which could result in a higher serum level.
DB11642
Temazepam may decrease the excretion rate of Pitolisant which could result in a higher serum level.
DB11901
Temazepam may decrease the excretion rate of Apalutamide which could result in a higher serum level.
DB15593
Temazepam may decrease the excretion rate of Golodirsen which could result in a higher serum level.
DB00879
Temazepam may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
DB14506
Temazepam may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level.
DB13987
Temazepam may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
DB04890
Temazepam may decrease the excretion rate of Bepotastine which could result in a higher serum level.
DB00982
Temazepam may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
DB04930
Temazepam may decrease the excretion rate of Permethrin which could result in a higher serum level.
DB09095
Temazepam may decrease the excretion rate of Difluocortolone which could result in a higher serum level.
DB00564
Temazepam may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
DB14509
Temazepam may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
DB00479
Amikacin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00684
Tobramycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00798
Gentamicin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00955
Netilmicin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00994
Neomycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01082
Streptomycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB01172
Kanamycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB03615
Ribostamycin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB04729
Gentamicin C1a may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB06696
Arbekacin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB12604
Sisomicin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB13540
Isepamicin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00552
Temazepam may decrease the excretion rate of Pentostatin which could result in a higher serum level.
DB13145
Temazepam may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
DB00314
Temazepam may decrease the excretion rate of Capreomycin which could result in a higher serum level.
DB00390
Temazepam may decrease the excretion rate of Digoxin which could result in a higher serum level.
DB00512
Temazepam may decrease the excretion rate of Vancomycin which could result in a higher serum level.
DB00515
Temazepam may decrease the excretion rate of Cisplatin which could result in a higher serum level.
DB00642
Temazepam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
DB01035
Temazepam may decrease the excretion rate of Procainamide which could result in a higher serum level.
DB12615
Temazepam may decrease the excretion rate of Plazomicin which could result in a higher serum level.
DB00908
Temazepam may decrease the excretion rate of Quinidine which could result in a higher serum level.
DB00682
Temazepam may decrease the excretion rate of Warfarin which could result in a higher serum level.
DB00803
Colistin may decrease the excretion rate of Temazepam which could result in a higher serum level.
DB00524
Temazepam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
DB00695
Temazepam may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
DB00808
Temazepam may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
DB00887
Temazepam may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
DB08907
Temazepam may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
DB09338
Temazepam may increase the excretion rate of Mersalyl which could result in a lower serum level and potentially a reduction in efficacy.
DB00232
Methyclothiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00310
Chlorthalidone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00311
Ethoxzolamide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00436
Bendroflumethiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00562
Benzthiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00594
Amiloride may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00606
Cyclothiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00774
Hydroflumethiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00880
Chlorothiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB01021
Trichlormethiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB01119
Diazoxide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB01144
Diclofenamide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB01324
Polythiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB01325
Quinethazone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB02925
Piretanide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB04831
Tienilic acid may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB05034
Ularitide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB08961
Azosemide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB09015
Canrenoic acid may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB09125
Potassium citrate may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB09401
Isosorbide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB11827
Ertugliflozin may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB12221
Canrenone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB12670
Rolofylline may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB12704
Spiradoline may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB12766
Cicletanine may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13284
Meticrane may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13405
Mefruside may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13430
Mebutizide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13532
Cyclopenthiazide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13617
Clorexolone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13663
Clofenamide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13708
Fenquizone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13792
Clopamide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13801
Muzolimine may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13803
Xipamide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB13989
Epitizide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB14500
Potassium may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00214
Torasemide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00421
Spironolactone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00700
Eplerenone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00703
Methazolamide may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00872
Conivaptan may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB01395
Drospirenone may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB06212
Tolvaptan may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB06292
Dapagliflozin may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB06370
Indisulam may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB09235
Efonidipine may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB01345
Temazepam may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
DB05077
The risk or severity of adverse effects can be increased when SLV319 is combined with Temazepam.
DB06155
The risk or severity of adverse effects can be increased when Rimonabant is combined with Temazepam.
DB06624
The risk or severity of adverse effects can be increased when Taranabant is combined with Temazepam.
DB09061
The risk or severity of adverse effects can be increased when Cannabidiol is combined with Temazepam.
DB11903
The risk or severity of adverse effects can be increased when GW842166 is combined with Temazepam.
DB12193
The risk or severity of adverse effects can be increased when Ajulemic acid is combined with Temazepam.
DB12649
The risk or severity of adverse effects can be increased when Ibipinabant is combined with Temazepam.
DB13070
The risk or severity of adverse effects can be increased when Surinabant is combined with Temazepam.
DB13950
The risk or severity of adverse effects can be increased when WIN 55212-2 is combined with Temazepam.
DB14011
The risk or severity of adverse effects can be increased when Nabiximols is combined with Temazepam.
DB14043
The risk or severity of adverse effects can be increased when Palmidrol is combined with Temazepam.
DB14737
The risk or severity of adverse effects can be increased when Cannabinol is combined with Temazepam.
DB00295
The risk or severity of adverse effects can be increased when Morphine is combined with Temazepam.
DB00318
The risk or severity of adverse effects can be increased when Codeine is combined with Temazepam.
DB00327
The risk or severity of adverse effects can be increased when Hydromorphone is combined with Temazepam.
DB00454
The risk or severity of adverse effects can be increased when Meperidine is combined with Temazepam.
DB00497
The risk or severity of adverse effects can be increased when Oxycodone is combined with Temazepam.
DB00611
The risk or severity of adverse effects can be increased when Butorphanol is combined with Temazepam.
DB00647
The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Temazepam.
DB00652
The risk or severity of adverse effects can be increased when Pentazocine is combined with Temazepam.
DB00704
The risk or severity of adverse effects can be increased when Naltrexone is combined with Temazepam.
DB00708
The risk or severity of adverse effects can be increased when Sufentanil is combined with Temazepam.
DB00802
The risk or severity of adverse effects can be increased when Alfentanil is combined with Temazepam.
DB00813
The risk or severity of adverse effects can be increased when Fentanyl is combined with Temazepam.
DB00844
The risk or severity of adverse effects can be increased when Nalbuphine is combined with Temazepam.
DB00854
The risk or severity of adverse effects can be increased when Levorphanol is combined with Temazepam.
DB00899
The risk or severity of adverse effects can be increased when Remifentanil is combined with Temazepam.
DB01081
The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Temazepam.
DB01192
The risk or severity of adverse effects can be increased when Oxymorphone is combined with Temazepam.
DB01209
The risk or severity of adverse effects can be increased when Dezocine is combined with Temazepam.
DB01227
The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Temazepam.
DB01433
The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Temazepam.
DB01450
The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Temazepam.
DB01452
The risk or severity of adverse effects can be increased when Diamorphine is combined with Temazepam.
DB01459
The risk or severity of adverse effects can be increased when Bezitramide is combined with Temazepam.
DB01466
The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Temazepam.
DB01497
The risk or severity of adverse effects can be increased when Etorphine is combined with Temazepam.
DB01529
The risk or severity of adverse effects can be increased when Dextromoramide is combined with Temazepam.
DB01531
The risk or severity of adverse effects can be increased when Desomorphine is combined with Temazepam.
DB01535
The risk or severity of adverse effects can be increased when Carfentanil is combined with Temazepam.
DB01551
The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Temazepam.
DB01555
The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Temazepam.
DB01565
The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Temazepam.
DB06738
The risk or severity of adverse effects can be increased when Ketobemidone is combined with Temazepam.
DB08861
The risk or severity of adverse effects can be increased when DPDPE is combined with Temazepam.
DB09174
The risk or severity of adverse effects can be increased when Lofentanil is combined with Temazepam.
DB09272
The risk or severity of adverse effects can be increased when Eluxadoline is combined with Temazepam.
DB11130
The risk or severity of adverse effects can be increased when Opium is combined with Temazepam.
DB11609
The risk or severity of adverse effects can be increased when Normethadone is combined with Temazepam.
DB12492
The risk or severity of adverse effects can be increased when Piritramide is combined with Temazepam.
DB13160
The risk or severity of adverse effects can be increased when Alphaprodine is combined with Temazepam.
DB13454
The risk or severity of adverse effects can be increased when Nicomorphine is combined with Temazepam.
DB13478
The risk or severity of adverse effects can be increased when Meptazinol is combined with Temazepam.
DB13605
The risk or severity of adverse effects can be increased when Phenoperidine is combined with Temazepam.
DB13606
The risk or severity of adverse effects can be increased when Phenazocine is combined with Temazepam.
DB13787
The risk or severity of adverse effects can be increased when Tilidine is combined with Temazepam.
DB15360
The risk or severity of adverse effects can be increased when Carfentanil, C-11 is combined with Temazepam.
DB15465
The risk or severity of adverse effects can be increased when Benzhydrocodone is combined with Temazepam.
DB11823
The risk or severity of adverse effects can be increased when Temazepam is combined with Esketamine.
DB00395
The risk or severity of adverse effects can be increased when Carisoprodol is combined with Temazepam.
DB06711
The risk or severity of CNS depression can be increased when Naphazoline is combined with Temazepam.
DB00402
The risk or severity of CNS depression can be increased when Temazepam is combined with Eszopiclone.
DB00575
The risk or severity of sedation can be increased when Clonidine is combined with Temazepam.
DB00924
The risk or severity of CNS depression can be increased when Temazepam is combined with Cyclobenzaprine.
DB01233
The risk or severity of sedation can be increased when Temazepam is combined with Metoclopramide.
DB11732
The risk or severity of adverse effects can be increased when Temazepam is combined with Lasmiditan.
DB00388
The risk or severity of hypertension can be decreased when Temazepam is combined with Phenylephrine.
DB00193
The risk or severity of CNS depression can be increased when Tramadol is combined with Temazepam.
DB00246
The risk or severity of adverse effects can be increased when Temazepam is combined with Ziprasidone.
DB00977
Ethinylestradiol may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
DB00502
The risk or severity of CNS depression can be increased when Temazepam is combined with Haloperidol.
DB06283
The risk or severity of CNS depression can be increased when Temazepam is combined with Ziconotide.
DB00472
The serum concentration of Fluoxetine can be increased when it is combined with Temazepam.
DB14881
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Temazepam is combined with Oliceridine.
序列
实验性质
Water Solubility
164 mg/L

Melting Point
119-121 °C
PhysProp
logP
2.19
HANSCH,C ET AL. (1995)
外部标识符
resource:Drugs Product Database (DPD)
identifier:2014
resource:ChEBI
identifier:9435
resource:PubChem Compound
identifier:5391
resource:PubChem Substance
identifier:46506604
resource:KEGG Compound
identifier:C07125
resource:KEGG Drug
identifier:D00370
resource:ChemSpider
identifier:5198
resource:BindingDB
identifier:50408032
resource:PharmGKB
identifier:PA451608
resource:Therapeutic Targets Database
identifier:DAP000238
resource:Wikipedia
identifier:Temazepam
resource:ChEMBL
identifier:CHEMBL967
resource:RxCUI
identifier:10355
外部链接
RxList
http://www.rxlist.com/cgi/generic/temaz.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/res1373.shtml
Drugs.com
http://www.drugs.com/temazepam.html
路径
目标
id:BE0004797
name:GABA(A) Receptor
organism:Humans
action:positive allosteric modulator
Sigel E, Steinmann ME: Structure, function, and modulation of GABA(A) receptors. J Biol Chem. 2012 Nov 23;287(48):40224-31. doi: 10.1074/jbc.R112.386664. Epub 2012 Oct 4.
Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE: Structure of a human synaptic GABAA receptor. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27.
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-1
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
gene-name:GABRA1
locus:5q34-q35
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 422-443
signal-regions:1-27
theoretical-pi:9.61
molecular-weight:51801.395
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4075GenAtlasGABRA1GenBank Gene DatabaseX13584GenBank Protein Database31631IUPHAR404Guide to Pharmacology404UniProtKBP14867UniProt AccessionGBRA1_HUMAN
synonyms:GABA(A) receptor subunit alpha-1
amino-acid-sequence:>lcl|BSEQ0010561|Gamma-aminobutyric acid receptor subunit alpha-1 MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
gene-sequence:>lcl|BSEQ0010562|Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) ATGAGGAAAAGTCCAGGTCTGTCTGACTGTCTTTGGGCCTGGATCCTCCTTCTGAGCACA CTGACTGGAAGAAGCTATGGACAGCCGTCATTACAAGATGAACTTAAAGACAATACCACT GTCTTCACCAGGATTTTGGACAGACTCCTAGATGGTTATGACAATCGCCTGAGACCAGGA TTGGGAGAGCGTGTAACCGAAGTGAAGACTGATATCTTCGTCACCAGTTTCGGACCCGTT TCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAA AGGTTAAAATTTAAAGGACCTATGACAGTCCTCCGGTTAAATAACCTAATGGCAAGTAAA ATCTGGACTCCGGACACATTTTTCCACAATGGAAAGAAGTCAGTGGCCCACAACATGACC ATGCCCAACAAACTCCTGCGGATCACAGAGGATGGCACCTTGCTGTACACCATGAGGCTG ACAGTGAGAGCTGAATGTCCGATGCATTTGGAGGACTTCCCTATGGATGCCCATGCTTGC CCACTAAAATTTGGAAGTTATGCTTATACAAGAGCAGAAGTTGTTTATGAATGGACCAGA GAGCCAGCACGCTCAGTGGTTGTAGCAGAAGATGGATCACGTCTAAACCAGTATGACCTT CTTGGACAAACAGTAGACTCTGGAATTGTCCAGTCAAGTACAGGAGAATATGTTGTTATG ACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCA TGCATAATGACAGTGATTCTCTCACAAGTCTCCTTCTGGCTCAACAGAGAGTCTGTACCA GCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACATTGAGCATCAGTGCC AGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCCGTGTGC TATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACTAAGAGA GGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCT CTTATTAAGAAAAACAACACTTACGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCC AGGGGCGACCCGGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCTAAAGAGGTC AAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGAC CGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCT ACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA receptor complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctiondrug bindingfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA2
locus:4p12
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 420-441
signal-regions:1-28
theoretical-pi:9.41
molecular-weight:51325.85
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4076GenAtlasGABRA2GenBank Gene DatabaseS62907GenBank Protein Database386422IUPHAR405Guide to Pharmacology405UniProtKBP47869UniProt AccessionGBRA2_HUMAN
synonyms:GABA(A) receptor subunit alpha-2
amino-acid-sequence:>lcl|BSEQ0037005|Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
gene-sequence:>lcl|BSEQ0010268|Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) ATGAAGACAAAATTGAACATCTACAACATGCAGTTCCTGCTTTTTGTTTTCTTGGTGTGG GACCCTGCCAGGTTGGTGCTGGCTAACATCCAAGAAGATGAGGCTAAAAATAACATTACC ATCTTTACGAGAATTCTTGACAGACTTCTGGATGGTTACGATAATCGGCTTAGACCAGGA CTGGGAGACAGTATTACTGAAGTCTTCACTAACATCTACGTGACCAGTTTTGGCCCTGTC TCAGATACAGATATGGAATATACAATTGATGTTTTCTTTCGACAAAAATGGAAAGATGAA CGTTTAAAATTTAAAGGTCCTATGAATATCCTTCGACTAAACAATTTAATGGCTAGCAAA ATCTGGACTCCAGATACCTTTTTTCACAATGGGAAAAAATCAGTAGCTCATAATATGACA ATGCCAAATAAGTTGCTTCGAATTCAGGATGATGGGACTCTGCTGTATACCATGAGGCTT ACAGTTCAAGCTGAATGCCCAATGCACTTGGAGGATTTCCCAATGGATGCTCATTCATGT CCTCTGAAATTTGGCAGCTATGCATATACAACTTCAGAGGTCACTTATATTTGGACTTAC AATGCATCTGATTCAGTACAGGTTGCTCCTGATGGCTCTAGGTTAAATCAATATGACCTG CTGGGCCAATCAATCGGAAAGGAGACAATTAAATCCAGTACAGGTGAATATACTGTAATG ACAGCTCATTTCCACCTGAAAAGAAAAATTGGGTATTTTGTGATTCAAACCTATCTGCCT TGCATCATGACTGTCATTCTCTCCCAAGTTTCATTCTGGCTTAACAGAGAATCTGTGCCT GCAAGAACTGTGTTTGGAGTAACAACTGTCCTAACAATGACAACTCTAAGCATCAGTGCT CGGAATTCTCTCCCCAAAGTGGCTTATGCAACTGCCATGGACTGGTTTATTGCTGTTTGT TATGCATTTGTGTTCTCTGCCCTAATTGAATTTGCAACTGTTAATTACTTCACCAAAAGA GGATGGGCTTGGGATGGGAAGAGTGTAGTAAATGACAAGAAAAAAGAAAAGGCTTCCGTT ATGATACAGAACAACGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAA GATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGAAGCCA GAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATG TCCAGAATAGTTTTTCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATAT TTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentaxoncomponentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentintegral component of synaptic vesicle membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessneurotransmitter transportprocessregulation of membrane potentialprocessregulation of neurotransmitter levelsprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transport
name:Gamma-aminobutyric acid receptor subunit alpha-3
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA3
locus:Xq28
cellular-location:Cell junction
transmembrane-regions:277-298 304-325 338-359 458-479
signal-regions:1-28
theoretical-pi:8.93
molecular-weight:55164.055
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4077GenAtlasGABRA3GenBank Gene DatabaseS62908GenBank Protein Database386424IUPHAR406Guide to Pharmacology406UniProtKBP34903UniProt AccessionGBRA3_HUMAN
synonyms:GABA(A) receptor subunit alpha-3
amino-acid-sequence:>lcl|BSEQ0016119|Gamma-aminobutyric acid receptor subunit alpha-3 MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRL NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN YFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN RESAIKGMIRKQ
gene-sequence:>lcl|BSEQ0016120|Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3) ATGATAATCACACAAACAAGTCACTGTTACATGACCAGCCTTGGGATTCTTTTCCTGATT AATATTCTCCCTGGAACCACTGGTCAAGGGGAATCAAGACGACAAGAACCCGGGGACTTT GTGAAGCAGGACATTGGCGGGCTGTCTCCTAAGCATGCCCCAGATATTCCTGATGACAGC ACTGACAACATCACTATCTTCACCAGAATCTTGGATCGTCTTCTGGACGGCTATGACAAC CGGCTGCGACCTGGGCTTGGAGATGCAGTGACTGAAGTGAAGACTGACATCTACGTGACC AGTTTTGGCCCTGTGTCAGACACTGACATGGAGTACACTATTGATGTATTTTTTCGGCAG ACATGGCATGATGAAAGACTGAAATTTGATGGCCCCATGAAGATCCTTCCACTGAACAAT CTCCTGGCTAGTAAGATCTGGACACCGGACACCTTCTTCCACAATGGCAAGAAATCAGTG GCTCATAACATGACCACGCCCAACAAGCTGCTCAGATTGGTGGACAACGGAACCCTCCTC TATACAATGAGGTTAACAATTCATGCTGAGTGTCCCATGCATTTGGAAGATTTTCCCATG GATGTGCATGCCTGCCCACTGAAGTTTGGAAGCTATGCCTATACAACAGCTGAAGTGGTT TATTCTTGGACTCTCGGAAAGAACAAATCCGTGGAAGTGGCACAGGATGGTTCTCGCTTG AACCAGTATGACCTTTTGGGCCATGTTGTTGGGACAGAGATAATCCGGTCTAGTACAGGA GAATATGTCGTCATGACAACCCACTTCCATCTCAAGCGAAAAATTGGCTACTTTGTGATC CAGACCTACTTGCCATGTATCATGACTGTCATTCTGTCACAAGTGTCGTTCTGGCTCAAC AGAGAGTCTGTTCCTGCCCGTACAGTCTTTGGTGTCACCACTGTGCTTACCATGACCACC TTGAGTATCAGTGCCAGAAATTCCTTACCTAAAGTGGCATATGCGACGGCCATGGACTGG TTCATAGCCGTCTGTTATGCCTTTGTATTTTCTGCACTGATTGAATTTGCCACTGTCAAC TATTTCACCAAGCGGAGTTGGGCTTGGGAAGGCAAGAAGGTGCCAGAGGCCCTGGAGATG AAGAAGAAAACACCAGCAGCCCCAGCAAAGAAAACCAGCACTACCTTCAACATCGTGGGG ACCACCTATCCCATCAACCTGGCCAAGGACACTGAATTTTCCACCATCTCCAAGGGCGCT GCTCCCAGTGCCTCCTCAACCCCAACAATCATTGCTTCACCCAAGGCCACCTACGTGCAG GACAGCCCGACTGAGACCAAGACCTACAACAGTGTCAGCAAGGTTGACAAAATTTCCCGC ATCATCTTTCCTGTGCTCTTTGCCATATTCAATCTGGTCTATTGGGCCACATATGTCAAC CGGGAGTCAGCTATCAAGGGCATGATCCGCAAACAGTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-4
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA4
locus:4p12
cellular-location:Cell junction
transmembrane-regions:259-280 285-306 318-340 524-543
signal-regions:1-35
theoretical-pi:10.0
molecular-weight:61622.645
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4078GenAtlasGABRA4GenBank Gene DatabaseU30461GenBank Protein Database905393IUPHAR407UniProtKBP48169UniProt AccessionGBRA4_HUMAN
synonyms:GABA(A) receptor subunit alpha-4
amino-acid-sequence:>lcl|BSEQ0018959|Gamma-aminobutyric acid receptor subunit alpha-4 MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV YLSKDTMEKSESLM
gene-sequence:>lcl|BSEQ0018960|Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) ATGGTTTCTGCCAAGAAGGTACCCGCGATCGCTCTGTCCGCCGGGGTCAGTTTCGCCCTC CTGCGCTTCCTGTGCCTGGCGGTTTGTTTAAACGAATCCCCAGGACAGAACCAAAAGGAG GAGAAATTGTGCACAGAAAATTTCACCCGCATCCTGGACAGTTTGCTCGATGGTTATGAC AACAGGCTGCGTCCTGGATTTGGGGGTCCTGTTACAGAAGTGAAAACTGACATATATGTC ACCAGCTTTGGACCTGTTTCTGATGTTGAAATGGAATACACAATGGATGTGTTCTTCAGG CAGACATGGATTGACAAAAGATTAAAATATGACGGCCCCATTGAAATTTTGAGATTGAAC AATATGATGGTAACGAAAGTGTGGACCCCTGATACTTTCTTCAGGAATGGAAAGAAATCT GTCTCACATAATATGACAGCTCCAAATAAGCTTTTTAGAATTATGAGAAATGGTACTATT TTATACACAATGAGACTCACCATAAGTGCGGAGTGTCCCATGAGATTGGTGGATTTTCCC ATGGATGGTCATGCATGCCCTTTGAAATTCGGGAGTTATGCCTATCCAAAGAGTGAGATG ATCTATACCTGGACAAAAGGTCCTGAGAAATCAGTTGAAGTTCCGAAGGAGTCTTCCAGC TTAGTTCAATATGATTTGATTGGGCAAACCGTATCAAGTGAAACCATCAAATCAATTACG GGTGAATATATTGTTATGACGGTTTACTTCCACCTCAGACGGAAGATGGGTTATTTTATG ATTCAGACCTATATTCCGTGCATTATGACAGTGATTCTTTCTCAAGTTTCATTTTGGATA AATAAAGAATCAGTTCCCGCTAGGACTGTATTTGGAATAACAACTGTCCTCACCATGACC ACACTAAGCATCAGTGCACGACATTCTTTGCCCAAAGTGTCCTATGCTACCGCCATGGAC TGGTTCATAGCTGTCTGCTTTGCTTTTGTATTTTCGGCCCTTATCGAGTTTGCTGCTGTC AACTATTTCACCAATATTCAAATGGAAAAAGCCAAAAGGAAGACATCAAAGCCCCCTCAG GAAGTTCCCGCTGCTCCAGTGCAGAGAGAGAAGCATCCTGAAGCCCCTCTGCAGAATACA AATGCCAATTTGAACATGAGAAAAAGAACAAATGCTTTGGTTCACTCTGAATCTGATGTT GGCAACAGAACTGAGGTGGGAAACCATTCAAGCAAATCTTCCACAGTTGTTCAAGAATCT TCTAAAGGCACACCTCGGTCTTACTTAGCTTCCAGTCCAAACCCATTCAGCCGTGCAAAT GCAGCTGAAACCATATCTGCAGCAAGAGCACTTCCATCTGCTTCTCCTACTTCTATCCGA ACTGGATATATGCCTCGAAAGGCTTCAGTTGGATCTGCTTCTACTCGTCACGTGTTTGGA TCAAGACTGCAGAGGATAAAGACCACAGTTAATACCATAGGGGCTACTGGGAAGTTGTCA GCTACTCCTCCTCCATCGGCTCCACCACCTTCTGGATCTGGCACAAGTAAAATAGACAAA TATGCCCGTATTCTCTTTCCAGTCACATTTGGGGCATTTAACATGGTTTATTGGGTTGTT TATTTATCTAAGGACACTATGGAGAAATCAGAAAGTCTAATGTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscentral nervous system developmentprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessregulation of response to drugprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-5
general-function:Transporter activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA5
locus:15q11.2-q12
cellular-location:Cell junction
transmembrane-regions:260-281 286-307 319-341 428-449
signal-regions:1-31
theoretical-pi:9.56
molecular-weight:52145.645
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4079GenAtlasGABRA5GenBank Gene DatabaseL08485GenBank Protein Database182916IUPHAR408Guide to Pharmacology408UniProtKBP31644UniProt AccessionGBRA5_HUMAN
synonyms:GABA(A) receptor subunit alpha-5
amino-acid-sequence:>lcl|BSEQ0010331|Gamma-aminobutyric acid receptor subunit alpha-5 MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
gene-sequence:>lcl|BSEQ0010332|Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) ATGGACAATGGAATGTTCTCTGGTTTTATCATGATCAAAAACCTCCTTCTCTTTTGTATT TCCATGAACTTATCCAGTCACTTTGGCTTTTCACAGATGCCAACCAGTTCAGTGAAAGAT GAGACCAATGACAACATCACGATATTTACCAGGATCTTGGATGGGCTCTTGGATGGCTAC GACAACAGACTTCGGCCCGGGCTGGGAGAGCGCATCACTCAGGTGAGGACCGACATCTAC GTCACCAGCTTCGGCCCGGTGTCCGACACGGAAATGGAGTACACCATAGACGTGTTTTTC CGACAAAGCTGGAAAGATGAAAGGCTTCGGTTTAAGGGGCCCATGCAGCGCCTCCCTCTC AACAACCTCCTTGCCAGCAAGATCTGGACCCCAGACACGTTCTTCCACAACGGGAAGAAG TCCATCGCTCACAACATGACCACGCCCAACAAGCTGCTGCGGCTGGAGGACGACGGCACC CTGCTCTACACCATGCGCTTGACCATCTCTGCAGAGTGCCCCATGCAGCTTGAGGACTTC CCGATGGATGCGCACGCTTGCCCTCTGAAATTTGGCAGCTATGCGTACCCTAATTCTGAA GTCGTTTACGTCTGGACCAACGGCTCCACCAAGTCGGTGGTGGTGGCGGAAGATGGCTCC AGACTGAACCAGTACCACCTGATGGGGCAGACGGTGGGCACTGAGAACATCAGCACCAGC ACAGGCGAATACACAATCATGACAGCTCACTTCCACCTGAAAAGGAAGATTGGCTACTTT GTCATCCAGACCTACCTTCCCTGCATAATGACCGTGATCTTATCACAGGTGTCCTTTTGG CTGAACCGGGAATCAGTCCCAGCCAGGACAGTTTTTGGGGTCACCACGGTGCTGACCATG ACGACCCTCAGCATCAGCGCCAGGAACTCTCTGCCCAAAGTGGCCTACGCCACCGCCATG GACTGGTTCATAGCCGTGTGCTATGCCTTCGTCTTCTCGGCGCTGATAGAGTTTGCCACG GTCAATTACTTTACCAAGAGAGGCTGGGCCTGGGATGGCAAAAAAGCCTTGGAAGCAGCC AAGATCAAGAAAAAGCGTGAAGTCATACTAAATAAGTCAACAAACGCTTTTACAACTGGG AAGATGTCTCACCCCCCAAACATTCCGAAGGAACAGACCCCAGCAGGGACGTCGAATACA ACCTCAGTCTCAGTAAAACCCTCTGAAGAGAAGACTTCTGAAAGCAAAAAGACTTACAAC AGTATCAGCAAAATTGACAAAATGTCCCGAATCGTATTCCCAGTCTTGTTCGGCACTTTC AACTTAGTTTACTGGGCAACGTATTTGAATAGGGAGCCGGTGATAAAAGGAGCCGCCTCT CCAAAATAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentdendritecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentneuronal cell body membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityfunctionreceptor activityfunctiontransporter activityprocessassociative learningprocessbehavioral fear responseprocessbrain developmentprocesschloride transmembrane transportprocesscochlea developmentprocessgamma-aminobutyric acid signaling pathwayprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessmitophagy in response to mitochondrial depolarizationprocessnegative regulation of neuron apoptotic processprocessneurological system processprocesspositive regulation of defense response to virus by hostprocessregulation of membrane potentialprocessresponse to drugprocesssensory perception of soundprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransportprocessxenophagy
name:Gamma-aminobutyric acid receptor subunit alpha-6
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA6
locus:5q34
cellular-location:Cell junction
transmembrane-regions:243-264 269-290 301-324 420-441
signal-regions:1-19
theoretical-pi:8.4
molecular-weight:51023.69
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4080GenAtlasGABRA6GenBank Gene DatabaseS81944GenBank Protein Database1470364IUPHAR409Guide to Pharmacology409UniProtKBQ16445UniProt AccessionGBRA6_HUMAN
synonyms:GABA(A) receptor subunit alpha-6
amino-acid-sequence:>lcl|BSEQ0010540|Gamma-aminobutyric acid receptor subunit alpha-6 MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
gene-sequence:>lcl|BSEQ0010541|Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) ATGGCGTCGTCTCTGCCCTGGCTGTGCATTATTCTGTGGCTAGAAAATGCCCTAGGGAAA CTCGAAGTTGAAGGCAACTTCTACTCAGAAAACGTCAGTCGGATCCTGGACAACTTGCTT GAAGGCTATGACAATCGGCTGCGGCCGGGATTTGGAGGTGCTGTCACTGAAGTCAAAACA GACATTTATGTGACCAGTTTTGGGCCCGTGTCAGATGTGGAGATGGAGTATACGATGGAT GTTTTTTTCCGCCAGACCTGGACTGATGAGAGGTTGAAGTTTGGGGGGCCAACTGAGATT CTGAGTCTGAATAATTTGATGGTCAGTAAAATCTGGACGCCTGACACCTTTTTCAGAAAT GGTAAAAAGTCCATTGCTCACAACATGACAACTCCTAATAAACTCTTCAGAATAATGCAG AATGGAACCATTTTATACACCATGAGGCTTACCATCAATGCTGACTGTCCCATGAGGCTG GTTAACTTTCCTATGGATGGGCATGCTTGTCCACTCAAGTTTGGGAGCTATGCTTATCCC AAAAGTGAAATCATATATACGTGGAAAAAAGGACCACTTTACTCAGTAGAAGTCCCAGAA GAATCTTCAAGCCTTCTCCAGTATGATCTGATTGGACAAACAGTATCTAGTGAGACAATT AAATCTAACACAGGTGAATACGTTATAATGACAGTTTACTTCCACTTGCAAAGGAAGATG GGCTACTTCATGATACAGATATACACTCCTTGCATTATGACAGTCATTCTTTCCCAGGTG TCTTTCTGGATTAATAAGGAGTCCGTCCCAGCAAGAACTGTTTTTGGGATCACCACTGTT TTAACTATGACCACTTTGAGCATCAGTGCCCGGCACTCTTTGCCAAAAGTGTCATATGCC ACTGCCATGGATTGGTTCATAGCTGTTTGCTTTGCATTCGTCTTCTCTGCGCTTATCGAG TTCGCAGCTGTCAACTACTTTACCAATCTTCAGACACAGAAGGCCAAAAGGAAGGCACAG TTTGCAGCCCCACCCACAGTGACAATATCAAAAGCTACTGAACCTTTGGAAGCTGAGATT GTTTTGCATCCTGACTCCAAATATCATCTGAAGAAAAGGATCACTTCTCTGTCTTTGCCA ATAGTTTCATCTTCCGAGGCCAATAAAGTGCTCACGAGAGCGCCCATCTTACAATCAACA CCTGTCACACCCCCACCACTCTCGCCAGCCTTTGGAGGCACCAGTAAAATAGACCAGTAT TCTCGAATTCTCTTCCCAGTTGCATTTGCAGGATTCAACCTTGTGTACTGGGTAGTTTAT CTTTCCAAAGATACAATGGAAGTCAGTAGCAGTGTTGAATAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit beta-1
general-function:Ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
gene-name:GABRB1
locus:4p12
cellular-location:Cell junction
transmembrane-regions:246-267 271-293 305-327 452-473
signal-regions:1-25
theoretical-pi:9.01
molecular-weight:54234.085
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4081GenAtlasGABRB1GenBank Gene DatabaseX14767GenBank Protein Database31635IUPHAR410UniProtKBP18505UniProt AccessionGBRB1_HUMAN
synonyms:GABA(A) receptor subunit beta-1
amino-acid-sequence:>lcl|BSEQ0004603|Gamma-aminobutyric acid receptor subunit beta-1 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
gene-sequence:>lcl|BSEQ0020610|Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) ATGTGGACAGTACAAAATCGAGAGAGTCTGGGGCTTCTCTCTTTCCCTGTGATGATTACC ATGGTCTGTTGTGCACACAGCACCAATGAACCCAGCAACATGTCATACGTGAAAGAGACA GTGGACAGATTGCTCAAAGGATATGACATTCGCTTGCGGCCGGACTTCGGAGGGCCCCCC GTCGACGTTGGGATGCGGATCGATGTCGCCAGCATAGACATGGTCTCCGAAGTGAATATG GATTATACACTCACCATGTATTTCCAGCAGTCTTGGAAAGACAAAAGGCTTTCTTATTCT GGAATCCCACTGAACCTCACCCTAGACAATAGGGTAGCTGACCAACTCTGGGTACCAGAC ACCTACTTTCTGAATGACAAGAAATCATTTGTGCATGGGGTCACAGTGAAAAATCGAATG ATTCGACTGCATCCTGATGGAACAGTTCTCTATGGACTCCGAATCACAACCACAGCTGCA TGTATGATGGATCTTCGAAGATATCCACTGGATGAGCAGAACTGCACCCTGGAGATCGAA AGTTATGGCTATACCACTGATGACATTGAATTTTACTGGAATGGAGGAGAAGGGGCAGTC ACTGGTGTTAATAAAATCGAACTTCCTCAATTTTCAATTGTTGACTACAAGATGGTGTCT AAGAAGGTGGAGTTCACAACAGGAGCGTATCCACGACTGTCACTAAGTTTTCGTCTAAAG AGAAACATTGGTTACTTCATTTTGCAAACCTACATGCCTTCTACACTGATTACAATTCTG TCCTGGGTGTCTTTTTGGATCAACTATGATGCATCTGCAGCCAGAGTCGCACTAGGAATC ACGACAGTGCTTACAATGACAACCATCAGCACCCACCTCAGGGAGACCCTGCCAAAGATC CCTTATGTCAAAGCGATTGATATTTATCTGATGGGTTGCTTTGTGTTTGTGTTCCTGGCT CTGCTGGAGTATGCCTTTGTAAATTACATCTTCTTTGGGAAAGGCCCTCAGAAAAAGGGA GCTAGCAAACAAGACCAGAGTGCCAATGAGAAGAATAAACTGGAGATGAATAAAGTCCAG GTCGACGCCCACGGTAACATTCTCCTCAGCACCCTGGAAATCCGGAATGAGACGAGTGGC TCGGAAGTGCTCACGAGCGTGAGCGACCCCAAGGCCACCATGTACTCCTATGACAGCGCC AGCATCCAGTACCGCAAGCCCCTGAGCAGCCGCGAGGCCTACGGGCGCGCCCTGGACCGG CACGGGGTACCCAGCAAGGGGCGCATCCGCAGGCGTGCCTCCCAGCTCAAAGTCAAGATC CCCGACTTGACTGATGTGAATTCCATAGACAAGTGGTCCCGAATGTTTTTCCCCATCACC TTTTCTCTTTTTAATGTCGTCTATTGGCTTTACTATGTACACTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentcytoplasmcomponentdendritecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentnuclear envelopecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityfunctionligand-gated ion channel activityprocesscellular response to histamineprocesscentral nervous system neuron developmentprocesschloride transmembrane transportprocession transmembrane transportprocession transportprocessneurological system processprocessovulation cycleprocessregulation of membrane potentialprocessresponse to progesteroneprocessresponse to toxic substanceprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit beta-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
gene-name:GABRB2
locus:5q34
cellular-location:Cell junction
transmembrane-regions:245-266 270-292 304-326 490-511
signal-regions:1-25
theoretical-pi:9.66
molecular-weight:59149.895
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4082GenAtlasGABRB2GenBank Gene DatabaseS67368GenBank Protein Database455946IUPHAR411UniProtKBP47870UniProt AccessionGBRB2_HUMAN
synonyms:GABA(A) receptor subunit beta-2
amino-acid-sequence:>lcl|BSEQ0037195|Gamma-aminobutyric acid receptor subunit beta-2 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKI FYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEA VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
gene-sequence:>lcl|BSEQ0011685|Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) ATGTGGAGAGTGCGGAAAAGGGGCTACTTTGGGATTTGGTCCTTCCCCTTAATAATCGCC GCTGTCTGTGCGCAGAGTGTCAATGACCCTAGTAATATGTCGCTGGTTAAAGAGACGGTG GATAGACTCCTGAAAGGCTATGACATTCGTCTGAGACCAGATTTTGGAGGTCCCCCCGTG GCTGTGGGGATGAACATTGACATTGCCAGCATCGATATGGTTTCTGAAGTCAATATGGAT TATACCTTGACAATGTACTTTCAACAAGCCTGGAGAGATAAGAGGCTGTCCTATAATGTA ATACCTTTAAACTTGACTCTGGACAACAGAGTGGCAGACCAGCTCTGGGTGCCTGATACC TATTTCCTGAACGATAAGAAGTCATTTGTGCACGGAGTGACTGTTAAGAACCGCATGATT CGCCTGCATCCTGATGGCACCGTCCTTTATGGACTCAGAATCACAACCACAGCTGCCTGC ATGATGGACCTAAGGAGGTACCCACTGGATGAACAAAACTGCACCTTGGAAATTGAGAGC TATGGATACACAACTGATGACATTGAGTTTTACTGGCGTGGCGATGATAATGCAGTAACA GGAGTAACGAAAATTGAACTTCCACAGTTCTCTATTGTAGATTACAAACTTATCACCAAG AAGGTTGTTTTTTCCACAGGTTCCTATCCCAGGTTATCCCTCAGCTTTAAGCTTAAGAGA AACATTGGCTACTTTATCCTGCAAACATACATGCCTTCCATCCTGATTACCATCCTCTCC TGGGTCTCCTTCTGGATTAATTACGATGCTTCAGCTGCAAGGGTGGCATTAGGAATCACA ACTGTCCTCACAATGACCACAATCAACACCCACCTCCGGGAAACTCTCCCTAAAATCCCC TATGTGAAGGCCATTGACATGTACCTGATGGGGTGCTTTGTCTTCGTTTTCATGGCCCTT CTGGAATATGCCCTAGTCAACTACATCTTCTTTGGGAGGGGGCCCCAACGCCAAAAGAAA GCAGCTGAGAAGGCTGCCAGTGCCAACAATGAGAAGATGCGCCTGGATGTCAACAAGATG GACCCCCATGAGAACATCTTACTGAGCACTCTCGAGATAAAAAATGAAATGGCCACATCT GAGGCTGTGATGGGACTTGGAGACCCCAGAAGCACAATGCTAGCCTATGATGCCTCCAGC ATCCAGTATCGGAAAGCTGGGTTGCCCAGGCATAGTTTTGGCCGAAATGCTCTGGAACGA CATGTGGCGCAAAAGAAAAGTCGCCTGAGGAGACGCGCCTCCCAACTGAAAATCACCATC CCTGACTTGACTGATGTGAATGCCATAGATCGGTGGTCCCGCATATTCTTCCCAGTGGTT TTTTCCTTCTTCAACATCGTCTATTGGCTTTATTATGTGAACTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentcytosolcomponentextracellular exosomecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocesscochlea developmentprocessgamma-aminobutyric acid signaling pathwayprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessnegative regulation of neuron apoptotic processprocessneurological system processprocessregulation of membrane potentialprocesssensory perception of soundprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit beta-3
general-function:Gaba-gated chloride ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
gene-name:GABRB3
locus:15q11.2-q12
cellular-location:Cell junction
transmembrane-regions:246-267 271-293 305-327 451-472
signal-regions:1-25
theoretical-pi:9.41
molecular-weight:54115.04
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4083GenAtlasGABRB3GenBank Gene DatabaseM82919GenBank Protein Database182925IUPHAR412Guide to Pharmacology412UniProtKBP28472UniProt AccessionGBRB3_HUMAN
synonyms:GABA(A) receptor subunit beta-3
amino-acid-sequence:>lcl|BSEQ0004605|Gamma-aminobutyric acid receptor subunit beta-3 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
gene-sequence:>lcl|BSEQ0016761|Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) ATGTGGGGCCTTGCGGGAGGAAGGCTTTTCGGCATCTTCTCGGCCCCGGTGCTGGTGGCT GTGGTGTGCTGCGCCCAGAGTGTGAACGATCCCGGGAACATGTCCTTTGTGAAGGAGACG GTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAGACCCGACTTCGGGGGTCCCCCG GTCTGCGTGGGGATGAACATCGACATCGCCAGCATCGACATGGTTTCCGAAGTCAACATG GATTATACCTTAACCATGTATTTTCAACAATATTGGAGAGATAAAAGGCTCGCCTATTCT GGGATCCCTCTCAACCTCACGCTTGACAATCGAGTGGCTGACCAGCTATGGGTGCCCGAC ACATATTTCTTAAATGACAAAAAGTCATTTGTGCATGGAGTGACAGTGAAAAACCGCATG ATCCGTCTTCACCCTGATGGGACAGTGCTGTATGGGCTCAGAATCACCACGACAGCAGCA TGCATGATGGACCTCAGGAGATACCCCCTGGACGAGCAGAACTGCACTCTGGAAATTGAA AGCTATGGCTACACCACGGATGACATTGAGTTTTACTGGCGAGGCGGGGACAAGGCTGTT ACCGGAGTGGAAAGGATTGAGCTCCCGCAGTTCTCCATCGTGGAGCACCGTCTGGTCTCG AGGAATGTTGTCTTCGCCACAGGTGCCTATCCTCGACTGTCACTGAGCTTTCGGTTGAAG AGGAACATTGGATACTTCATTCTTCAGACTTATATGCCCTCTATACTGATAACGATTCTG TCGTGGGTGTCCTTCTGGATCAATTATGATGCATCTGCTGCTAGAGTTGCCCTCGGGATC ACAACTGTGCTGACAATGACAACCATCAACACCCACCTTCGGGAGACCTTGCCCAAAATC CCCTATGTCAAAGCCATTGACATGTACCTTATGGGCTGCTTCGTCTTTGTGTTCCTGGCC CTTCTGGAGTATGCCTTTGTCAACTACATTTTCTTTGGAAGAGGCCCTCAAAGGCAGAAG AAGCTTGCAGAAAAGACAGCCAAGGCAAAGAATGACCGTTCAAAGAGCGAAAGCAACCGG GTGGATGCTCATGGAAATATTCTGTTGACATCGCTGGAAGTTCACAATGAAATGAATGAG GTCTCAGGCGGCATTGGCGATACCAGGAATTCAGCAATATCCTTTGACAACTCAGGAATC CAGTACAGGAAACAGAGCATGCCTCGAGAAGGGCATGGGCGATTCCTGGGGGACAGAAGC CTCCCGCACAAGAAGACCCATCTACGGAGGAGGTCTTCACAGCTCAAAATTAAAATACCT GATCTAACCGATGTGAATGCCATAGACAGATGGTCCAGGATCGTGTTTCCATTCACTTTT TCTCTTTTCAACTTAGTTTACTGGCTGTACTATGTTAACTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityfunctionGABA-gated chloride ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocesscochlea developmentprocessinhibitory postsynaptic potentialprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessnegative regulation of neuron apoptotic processprocessneurological system processprocesspalate developmentprocessregulation of membrane potentialprocesssensory perception of soundprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit delta
general-function:Gaba-a receptor activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRD
locus:1p|1p36.3
cellular-location:Cell junction
transmembrane-regions:249-271 275-297 309-331 430-452
signal-regions:1-16
theoretical-pi:8.73
molecular-weight:50707.835
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4084GenBank Gene DatabaseAF016917GenBank Protein Database2388693UniProtKBO14764UniProt AccessionGBRD_HUMAN
synonyms:GABA(A) receptor subunit delta
amino-acid-sequence:>lcl|BSEQ0012501|Gamma-aminobutyric acid receptor subunit delta MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIG GPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLW LPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECML DLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLH FHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSS LPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAI VLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM
gene-sequence:>lcl|BSEQ0012502|Gamma-aminobutyric acid receptor subunit delta (GABRD) ATGGACGCGCCCGCCCGGCTGCTGGCCCCGCTCCTGCTCCTCTGCGCGCAGCAGCTCCGC GGCACCAGAGCGATGAATGACATCGGCGACTACGTGGGCTCCAACCTGGAGATCTCCTGG CTCCCCAACCTGGACGGGCTGATAGCCGGCTACGCCCGCAACTTCCGGCCTGGCATCGGA GGCCCCCCCGTGAATGTGGCCCTTGCCCTGGAGGTGGCCAGCATCGACCACATCTCAGAG GCCAACATGGAGTACACCATGACGGTGTTCCTGCACCAGAGCTGGCGGGACAGCAGGCTC TCCTACAACCACACCAACGAGACCCTGGGTCTGGACAGCCGCTTCGTGGACAAGCTGTGG CTGCCCGACACCTTCATCGTGAACGCCAAGTCGGCCTGGTTCCACGACGTGACGGTGGAG AACAAGCTCATCCGGCTGCAGCCCGACGGCGTGATCCTGTACAGCATCCGAATCACCTCC ACTGTGGCCTGCGACATGGACCTGGCCAAATACCCCATGGACGAGCAGGAGTGCATGCTG GACCTGGAGAGCTACGGTTACTCATCGGAGGACATCGTCTACTACTGGTCGGAGAGCCAG GAGCACATCCACGGGCTGGACAAGCTGCAGCTGGCGCAGTTCACCATCACCAGCTACCGC TTCACCACGGAGCTGATGAACTTCAAGTCCGCTGGCCAGTTCCCACGGCTCAGCCTGCAC TTCCACCTGCGGAGGAACCGCGGCGTGTACATCATCCAATCCTACATGCCCTCCGTCCTG CTGGTCGCCATGTCCTGGGTCTCCTTCTGGATCAGCCAGGCGGCGGTGCCCGCCAGGGTG TCTCTAGGCATCACCACGGTGCTGACGATGACCACGCTCATGGTCAGTGCCCGCTCCTCC CTGCCACGGGCATCAGCCATCAAGGCACTGGACGTCTACTTCTGGATCTGCTATGTCTTC GTGTTTGCCGCCCTGGTGGAGTACGCCTTTGCTCATTTCAACGCCGACTACAGGAAGAAG CAGAAGGCCAAGGTCAAGGTCTCCAGGCCGAGGGCAGAGATGGACGTGAGGAACGCCATT GTCCTCTTCTCCCTCTCTGCTGCCGGCGTCACGCAGGAGCTGGCCATCTCCCGCCGGCAG CGCCGCGTCCCGGGGAACCTGATGGGCTCCTACAGGTCGGTGGGGGTGGAGACAGGGGAG ACGAAGAAGGAGGGGGCAGCCCGCTCAGGAGGCCAGGGGGGCATCCGTGCCCGGCTCAGG CCCATCGACGCAGACACCATTGACATTTACGCCCGCGCTGTGTTCCCTGCGGCGTTTGCG GCCGTCAATGTCATCTACTGGGCGGCATACGCCATGTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityprocesschloride transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocesssignal transductionprocesssynaptic transmissionprocesstransport
name:Gamma-aminobutyric acid receptor subunit epsilon
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRE
locus:
cellular-location:Cell junction
transmembrane-regions:254-274 281-301 344-364 486-506
signal-regions:1-22
theoretical-pi:8.09
molecular-weight:57971.175
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4085GenBank Gene DatabaseU66661GenBank Protein Database1857126UniProtKBP78334UniProt AccessionGBRE_HUMAN
synonyms:GABA(A) receptor subunit epsilon
amino-acid-sequence:>lcl|BSEQ0006923|Gamma-aminobutyric acid receptor subunit epsilon MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL DNYSRVVFPVTFFFFNVLYWLVCLNL
gene-sequence:>lcl|BSEQ0020703|Gamma-aminobutyric acid receptor subunit epsilon (GABRE) ATGTTGTCCAAAGTTCTTCCAGTCCTCCTAGGCATCTTATTGATCCTCCAGTCGAGGGTC GAGGGACCTCAGACTGAATCAAAGAATGAAGCCTCTTCCCGTGATGTTGTCTATGGCCCC CAGCCCCAGCCTCTGGAAAATCAGCTCCTCTCTGAGGAAACAAAGTCAACTGAGACTGAG ACTGGGAGCAGAGTTGGCAAACTGCCAGAAGCCTCTCGCATCCTGAACACTATCCTGAGT AATTATGACCACAAACTGCGCCCTGGCATTGGAGAGAAGCCCACTGTGGTCACTGTTGAG ATCTCCGTCAACAGCCTTGGTCCTCTCTCTATCCTAGACATGGAATACACCATTGACATC ATCTTCTCCCAGACCTGGTACGACGAACGCCTCTGTTACAACGACACCTTTGAGTCTCTT GTTCTGAATGGCAATGTGGTGAGCCAGCTATGGATCCCGGACACCTTTTTTAGGAATTCT AAGAGGACCCACGAGCATGAGATCACCATGCCCAACCAGATGGTCCGCATCTACAAGGAT GGCAAGGTGTTGTACACAATTAGGATGACCATTGATGCCGGATGCTCACTCCACATGCTC AGATTTCCAATGGATTCTCACTCTTGCCCTCTATCTTTCTCTAGCTTTTCCTATCCTGAG AATGAGATGATCTACAAGTGGGAAAATTTCAAGCTTGAAATCAATGAGAAGAACTCCTGG AAGCTCTTCCAGTTTGATTTTACAGGAGTGAGCAACAAAACTGAAATAATCACAACCCCA GTTGGTGACTTCATGGTCATGACGATTTTCTTCAATGTGAGCAGGCGGTTTGGCTATGTT GCCTTTCAAAACTATGTCCCTTCTTCCGTGACCACGATGCTCTCCTGGGTTTCCTTTTGG ATCAAGACAGAGTCTGCTCCAGCCCGGACCTCTCTAGGGATCACCTCTGTTCTGACCATG ACCACGTTGGGCACCTTTTCTCGTAAGAATTTCCCGCGTGTCTCCTATATCACAGCCTTG GATTTCTATATCGCCATCTGCTTCGTCTTCTGCTTCTGCGCTCTGTTGGAGTTTGCTGTG CTCAACTTCCTGATCTACAACCAGACAAAAGCCCATGCTTCTCCTAAACTCCGCCATCCT CGTATCAATAGCCGTGCCCATGCCCGTACCCGTGCACGTTCCCGAGCCTGTGCCCGCCAA CATCAGGAAGCTTTTGTGTGCCAGATTGTCACCACTGAGGGAAGTGATGGAGAGGAGCGC CCGTCTTGCTCAGCCCAGCAGCCCCCTAGCCCAGGTAGCCCTGAGGGTCCCCGCAGCCTC TGCTCCAAGCTGGCCTGCTGTGAGTGGTGCAAGCGTTTTAAGAAGTACTTCTGCATGGTC CCCGATTGTGAGGGCAGTACCTGGCAGCAGGGCCGCCTCTGCATCCATGTCTACCGCCTG GATAACTACTCGAGAGTTGTTTTCCCAGTGACTTTCTTCTTCTTCAATGTGCTCTACTGG CTTGTTTGCCTTAACTTGTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransport
name:Gamma-aminobutyric acid receptor subunit gamma-1
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRG1
locus:4p12
cellular-location:Cell junction
transmembrane-regions:273-294 299-320 332-354 445-465
signal-regions:1-35
theoretical-pi:8.23
molecular-weight:53594.49
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4086GenBank Gene DatabaseAK122845GenBank Protein Database193783776UniProtKBQ8N1C3UniProt AccessionGBRG1_HUMAN
synonyms:GABA(A) receptor subunit gamma-1
amino-acid-sequence:>lcl|BSEQ0012496|Gamma-aminobutyric acid receptor subunit gamma-1 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
gene-sequence:>lcl|BSEQ0012497|Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1) ATGGGTCCTTTGAAAGCTTTTCTCTTCTCCCCTTTTCTTCTGCGGAGTCAAAGTAGAGGG GTGAGGTTGGTCTTCTTGTTACTGACCCTGCATTTGGGAAACTGTGTTGATAAGGCAGAT GATGAAGATGATGAGGATTTAACGGTGAACAAAACCTGGGTCTTGGCCCCAAAAATTCAT GAAGGAGATATCACACAAATTCTGAATTCATTGCTTCAAGGCTATGACAATAAACTTCGT CCAGATATAGGAGTGAGGCCCACAGTAATTGAAACTGATGTTTATGTAAACAGCATTGGA CCAGTTGATCCAATTAATATGGAATATACAATAGATATAATTTTTGCCCAAACCTGGTTT GACAGTCGTTTAAAATTCAATAGTACCATGAAAGTGCTTATGCTTAACAGTAATATGGTT GGAAAAATTTGGATTCCTGACACTTTCTTCAGAAACTCAAGAAAATCTGATGCTCACTGG ATAACAACTCCTAATCGTCTGCTTCGAATTTGGAATGATGGACGAGTTCTGTATACTCTA AGATTGACAATTAATGCAGAATGTTATCTTCAGCTTCATAACTTTCCCATGGATGAACAT TCCTGTCCACTGGAATTTTCAAGCTATGGATACCCTAAAAATGAAATTGAGTATAAGTGG AAAAAGCCCTCCGTAGAAGTGGCTGATCCTAAATACTGGAGATTATATCAGTTTGCATTT GTAGGGTTACGGAACTCAACTGAAATCACTCACACGATCTCTGGGGATTATGTTATCATG ACAATTTTTTTTGACCTGAGCAGAAGAATGGGATATTTCACTATTCAGACCTACATTCCA TGCATTCTGACAGTTGTTCTTTCTTGGGTGTCTTTTTGGATCAATAAAGATGCAGTGCCT GCAAGAACATCGTTGGGTATCACTACAGTTCTGACTATGACAACCCTGAGTACAATTGCC AGGAAGTCTTTACCTAAGGTTTCTTATGTGACTGCGATGGATCTCTTTGTTTCTGTTTGT TTCATTTTTGTTTTTGCAGCCTTGATGGAATATGGAACCTTGCATTATTTTACCAGCAAC CAAAAAGGAAAGACTGCTACTAAAGACAGAAAGCTAAAAAATAAAGCCTCGATGACTCCT GGTCTCCATCCTGGATCCACTCTGATTCCAATGAATAATATTTCTGTGCCGCAAGAAGAT GATTATGGGTATCAGTGTTTGGAGGGCAAAGATTGTGCCAGCTTCTTCTGTTGCTTTGAA GACTGCAGAACAGGATCTTGGAGGGAAGGAAGGATACACATACGCATTGCCAAAATTGAC TCTTATTCTAGAATATTTTTCCCAACCGCTTTTGCCCTGTTCAACTTGGTTTATTGGGTT GGCTATCTTTACTTATAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmission
name:Gamma-aminobutyric acid receptor subunit gamma-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
gene-name:GABRG2
locus:5q31.1-q33.1
cellular-location:Cell junction
transmembrane-regions:274-296 300-322 334-356 444-466
signal-regions:1-39
theoretical-pi:8.6
molecular-weight:54161.78
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4087GenBank Gene DatabaseX15376GenBank Protein Database31637UniProtKBP18507UniProt AccessionGBRG2_HUMAN
synonyms:GABA(A) receptor subunit gamma-2
amino-acid-sequence:>lcl|BSEQ0006917|Gamma-aminobutyric acid receptor subunit gamma-2 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
gene-sequence:>lcl|BSEQ0019445|Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) ATGAGTTCGCCAAATATATGGAGCACAGGAAGCTCAGTCTACTCGACTCCTGTATTTTCA CAGAAAATGACGGTGTGGATTCTGCTCCTGCTGTCGCTCTACCCTGGCTTCACTAGCCAG AAATCTGATGATGACTATGAAGATTATGCTTCTAACAAAACATGGGTCTTGACTCCAAAA GTTCCTGAGGGTGATGTCACTGTCATCTTAAACAACCTGCTGGAAGGATATGACAATAAA CTTCGGCCTGATATAGGAGTGAAGCCAACGTTAATTCACACAGACATGTATGTGAATAGC ATTGGTCCAGTGAACGCTATCAATATGGAATACACTATTGATATATTTTTTGCGCAAACG TGGTATGACAGACGTTTGAAATTTAACAGCACCATTAAAGTCCTCCGATTGAACAGCAAC ATGGTGGGGAAAATCTGGATTCCAGACACTTTCTTCAGAAATTCCAAAAAAGCTGATGCA CACTGGATCACCACCCCCAACAGGATGCTGAGAATTTGGAATGATGGTCGAGTGCTCTAC ACCCTAAGGTTGACAATTGATGCTGAGTGCCAATTACAATTGCACAACTTTCCAATGGAT GAACACTCCTGCCCCTTGGAGTTCTCCAGTTATGGCTATCCACGTGAAGAAATTGTTTAT CAATGGAAGCGAAGTTCTGTTGAAGTGGGCGACACAAGATCCTGGAGGCTTTATCAATTC TCATTTGTTGGTCTAAGAAATACCACCGAAGTAGTGAAGACAACTTCCGGAGATTATGTG GTCATGTCTGTCTACTTTGATCTGAGCAGAAGAATGGGATACTTTACCATCCAGACCTAT ATCCCCTGCACACTCATTGTCGTCCTATCCTGGGTGTCTTTCTGGATCAATAAGGATGCT GTTCCAGCCAGAACATCTTTAGGTATCACCACTGTCCTGACAATGACCACCCTCAGCACC ATTGCCCGGAAATCGCTCCCCAAGGTCTCCTATGTCACAGCGATGGATCTCTTTGTATCT GTTTGTTTCATCTTTGTCTTCTCTGCTCTGGTGGAGTATGGCACCTTGCATTATTTTGTC AGCAACCGGAAACCAAGCAAGGACAAAGATAAAAAGAAGAAAAACCCTGCCCCTACCATT GATATCCGCCCAAGATCAGCAACCATTCAAATGAATAATGCTACACACCTTCAAGAGAGA GATGAAGAGTACGGCTATGAGTGTCTGGACGGCAAGGACTGTGCCAGTTTTTTCTGCTGT TTTGAAGATTGTCGAACAGGAGCTTGGAGACATGGGAGGATACATATCCGCATTGCCAAA ATGGACTCCTATGCTCGGATCTTCTTCCCCACTGCCTTCTGCCTGTTTAATCTGGTCTAT TGGGTCTCCTACCTCTACCTGTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentaxoncomponentcell junctioncomponentchloride channel complexcomponentdendrite membranecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocessadult behaviorprocesscellular response to histamineprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocesspost-embryonic developmentprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit gamma-3
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRG3
locus:15q12
cellular-location:Cell junction
transmembrane-regions:255-277 281-303 315-337 444-467
signal-regions:1-17
theoretical-pi:7.58
molecular-weight:54288.16
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4088GenBank Gene DatabaseS82769GenBank Protein Database1754749UniProtKBQ99928UniProt AccessionGBRG3_HUMAN
synonyms:GABA(A) receptor subunit gamma-3
amino-acid-sequence:>lcl|BSEQ0006921|Gamma-aminobutyric acid receptor subunit gamma-3 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDK KLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNS NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPM DEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDY VVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLS TIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDS SRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
gene-sequence:>lcl|BSEQ0012498|Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3) ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGA AAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCA AAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAAC AGCATTGGTCCTGTGTCATCAATAAACATGGAATACCAAATTGACATATTTTTTGCTCAG ACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGC AACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAG GCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTT TACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATG GACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATT TATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAG TTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTAGGAAT TTACTGAAAGAGGCACAGCTCTCAAAAGCCAGAGAGGCCTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transport
name:Gamma-aminobutyric acid receptor subunit pi
general-function:Gaba-a receptor activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
gene-name:GABRP
locus:5q33-q34
cellular-location:Cell junction
transmembrane-regions:243-266 270-292 305-327 417-438
signal-regions:1-16
theoretical-pi:6.99
molecular-weight:50639.735
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4089GenBank Gene DatabaseU95367GenBank Protein Database2197001UniProtKBO00591UniProt AccessionGBRP_HUMAN
synonyms:GABA(A) receptor subunit pi
amino-acid-sequence:>lcl|BSEQ0017152|Gamma-aminobutyric acid receptor subunit pi MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL LFPLIFMLANVFYWAYYMYF
gene-sequence:>lcl|BSEQ0017153|Gamma-aminobutyric acid receptor subunit pi (GABRP) ATGAACTACAGCCTCCACTTGGCCTTCGTGTGTCTGAGTCTCTTCACTGAGAGGATGTGC ATCCAGGGGAGTCAGTTCAACGTCGAGGTCGGCAGAAGTGACAAGCTTTCCCTGCCTGGC TTTGAGAACCTCACAGCAGGATATAACAAATTTCTCAGGCCCAATTTTGGTGGAGAACCC GTACAGATAGCGCTGACTCTGGACATTGCAAGTATCTCTAGCATTTCAGAGAGTAACATG GACTACACAGCCACCATATACCTCCGACAGCGCTGGATGGACCAGCGGCTGGTGTTTGAA GGCAACAAGAGCTTCACTCTGGATGCCCGCCTCGTGGAGTTCCTCTGGGTGCCAGATACT TACATTGTGGAGTCCAAGAAGTCCTTCCTCCATGAAGTCACTGTGGGAAACAGGCTCATC CGCCTCTTCTCCAATGGCACGGTCCTGTATGCCCTCAGAATCACGACAACTGTTGCATGT AACATGGATCTGTCTAAATACCCCATGGACACACAGACATGCAAGTTGCAGCTGGAAAGC TGGGGCTATGATGGAAATGATGTGGAGTTCACCTGGCTGAGAGGGAACGACTCTGTGCGT GGACTGGAACACCTGCGGCTTGCTCAGTACACCATAGAGCGGTATTTCACCTTAGTCACC AGATCGCAGCAGGAGACAGGAAATTACACTAGATTGGTCTTACAGTTTGAGCTTCGGAGG AATGTTCTGTATTTCATTTTGGAAACCTACGTTCCTTCCACTTTCCTGGTGGTGTTGTCC TGGGTTTCATTTTGGATCTCTCTCGATTCAGTCCCTGCAAGAACCTGCATTGGGGACAAC AAAGGAAGTAGAAGAAGTCAGTATTACTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityprocesschloride transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocesssignal transductionprocesssynaptic transmission
name:Gamma-aminobutyric acid receptor subunit theta
general-function:Transmembrane signaling receptor activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRQ
locus:
cellular-location:Cell junction
transmembrane-regions:269-289 327-347 612-632
signal-regions:1-21
theoretical-pi:5.76
molecular-weight:72020.875
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:14454GenBank Gene DatabaseAF189259GenBank Protein Database7861736UniProtKBQ9UN88UniProt AccessionGBRT_HUMAN
synonyms:GABA(A) receptor subunit theta
amino-acid-sequence:>lcl|BSEQ0012499|Gamma-aminobutyric acid receptor subunit theta MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQ KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRR QPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIFPT EIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFN PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY
gene-sequence:>lcl|BSEQ0012500|Gamma-aminobutyric acid receptor subunit theta (GABRQ) ATGGGCATCCGAGGCATGCTGCGAGCCGCAGTGATCCTGCTGCTCATCAGGACCTGGCTC GCGGAGGGCAACTACCCCAGTCCCATCCCGAAATTCCACTTCGAGTTCTCCTCTGCTGTG CCCGAAGTCGTCCTGAACCTCTTCAACTGCAAAAATTGTGCAAATGAAGCTGTGGTTCAA AAGATTTTGGACAGGGTGCTGTCAAGATACGATGTCCGCCTGAGACCGAATTTTGGAGGT GCCCCTGTGCCTGTGAGAATATCTATTTATGTCACGAGCATTGAACAGATCTCAGAAATG AATATGGACTACACGATCACGATGTTTTTTCATCAGACTTGGAAAGATTCACGCTTAGCA TACTATGAGACCACCCTGAACTTGACCCTGGACTATCGGATGCATGAGAAGTTGTGGGTC CCTGACTGCTACTTTCTGAACAGCAAGGATGCTTTCGTGCATGATGTGACTGTGGAGAAT CGCGTGTTTCAGCTTCACCCAGATGGAACGGTGCGGTACGGCATCCGACTCACCACTACA GCAGCTTGTTCCCTGGATCTGCATAAATTCCCTATGGACAAGCAGGCCTGCAACCTGGTG GTAGAGAGCTATGGTTACACGGTTGAAGACATCATATTATTCTGGGATGACAATGGGAAC GCCATCCACATGACTGAGGAGCTGCATATCCCTCAGTTCACTTTCCTGGGAAGGACGATT ACTAGCAAGGAGGTGTATTTCTACACAGGTTCCTACATACGCCTGATACTGAAGTTCCAG GTTCAGAGGGAAGTTAACAGCTACCTTGTGCAAGTCTACTGGCCTACTGTCCTCACCACT ATTACCTCTTGGATATCGTTTTGGATGAACTATGATTCCTCTGCAGCCAGGGTGACAATT GGCTTAACTTCAATGCTCATCCTGACCACCATCGACTCACATCTGCGGGATAAGCTCCCC AACATTTCCTGTATCAAGGCCATTGATATCTATATCCTCGTGTGCTTGTTCTTTGTGTTC CTGTCCTTGCTGGAGTATGTCTACATCAACTATCTTTTCTACAGTCGAGGACCTCGGCGC CAGCCTAGGCGACACAGGAGACCCCGAAGAGTCATTGCCCGCTACCGCTACCAGCAAGTG GTGGTAGGAAACGTGCAGGATGGCCTGATTAACGTGGAAGACGGAGTCAGCTCTCTCCCC ATCACCCCAGCGCAGGCCCCCCTGGCAAGCCCGGAAAGCCTCGGTTCTTTGACGTCCACC TCCGAGCAGGCCCAGCTGGCCACCTCGGAAAGCCTCAGCCCACTCACTTCTCTCTCAGGC CAGGCCCCCCTGGCCACTGGAGAAAGCCTGAGCGATCTCCCCTCCACCTCAGAGCAGGCC CGGCACAGCTATGGTGTTCGCTTTAATGGTTTCCAGGCTGATGACAGTATTATTCCTACC GAAATCCGCAACCGTGTCGAAGCCCATGGCCATGGTGTTACCCATGACCATGAAGATTCC AATGAGAGCTTGAGCTCGGATGAGCGCCATGGCCATGGCCCCAGTGGGAAGCCCATGCTT CACCATGGCGAGAAGGGTGTGCAAGAAGCAGGCTGGGACCTTGATGACAACAATGACAAG AGCGACTGCCTTGCCATTAAGGAGCAATTCAAGTGTGATACTAACAGTACCTGGGGCCTT AATGATGATGAGCTCATGGCCCATGGCCAAGAGAAGGACAGTAGCTCAGAGTCTGAGGAT AGTTGCCCCCCAAGCCCTGGGTGCTCCTTCACTGAAGGGTTCTCCTTCGATCTCTTTAAT CCTGACTACGTCCCAAAGGTCGACAAGTGGTCCCGGTTCCTCTTCCCTCTGGCCTTTGGG TTGTTCAACATTGTTTACTGGGTATACCATATGTATTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentreceptor complexcomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityfunctionneurotransmitter transporter activityfunctiontransmembrane signaling receptor activityprocesschloride transmembrane transportprocession transmembrane transportprocessneurological system processprocessneurotransmitter transportprocessregulation of membrane potentialprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transport
id:BE0008668
name:GABA(A) Receptor Benzodiazepine Binding Site
organism:Humans
action:ligand
Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE: Structure of a human synaptic GABAA receptor. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27.
Sigel E, Steinmann ME: Structure, function, and modulation of GABA(A) receptors. J Biol Chem. 2012 Nov 23;287(48):40224-31. doi: 10.1074/jbc.R112.386664. Epub 2012 Oct 4.
known-action:unknown
name:Gamma-aminobutyric acid receptor subunit alpha-1
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
gene-name:GABRA1
locus:5q34-q35
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 422-443
signal-regions:1-27
theoretical-pi:9.61
molecular-weight:51801.395
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4075GenAtlasGABRA1GenBank Gene DatabaseX13584GenBank Protein Database31631IUPHAR404Guide to Pharmacology404UniProtKBP14867UniProt AccessionGBRA1_HUMAN
synonyms:GABA(A) receptor subunit alpha-1
amino-acid-sequence:>lcl|BSEQ0010561|Gamma-aminobutyric acid receptor subunit alpha-1 MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
gene-sequence:>lcl|BSEQ0010562|Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) ATGAGGAAAAGTCCAGGTCTGTCTGACTGTCTTTGGGCCTGGATCCTCCTTCTGAGCACA CTGACTGGAAGAAGCTATGGACAGCCGTCATTACAAGATGAACTTAAAGACAATACCACT GTCTTCACCAGGATTTTGGACAGACTCCTAGATGGTTATGACAATCGCCTGAGACCAGGA TTGGGAGAGCGTGTAACCGAAGTGAAGACTGATATCTTCGTCACCAGTTTCGGACCCGTT TCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAA AGGTTAAAATTTAAAGGACCTATGACAGTCCTCCGGTTAAATAACCTAATGGCAAGTAAA ATCTGGACTCCGGACACATTTTTCCACAATGGAAAGAAGTCAGTGGCCCACAACATGACC ATGCCCAACAAACTCCTGCGGATCACAGAGGATGGCACCTTGCTGTACACCATGAGGCTG ACAGTGAGAGCTGAATGTCCGATGCATTTGGAGGACTTCCCTATGGATGCCCATGCTTGC CCACTAAAATTTGGAAGTTATGCTTATACAAGAGCAGAAGTTGTTTATGAATGGACCAGA GAGCCAGCACGCTCAGTGGTTGTAGCAGAAGATGGATCACGTCTAAACCAGTATGACCTT CTTGGACAAACAGTAGACTCTGGAATTGTCCAGTCAAGTACAGGAGAATATGTTGTTATG ACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCA TGCATAATGACAGTGATTCTCTCACAAGTCTCCTTCTGGCTCAACAGAGAGTCTGTACCA GCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACATTGAGCATCAGTGCC AGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCCGTGTGC TATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACTAAGAGA GGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCT CTTATTAAGAAAAACAACACTTACGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCC AGGGGCGACCCGGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCTAAAGAGGTC AAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGAC CGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCT ACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA receptor complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctiondrug bindingfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA2
locus:4p12
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 420-441
signal-regions:1-28
theoretical-pi:9.41
molecular-weight:51325.85
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4076GenAtlasGABRA2GenBank Gene DatabaseS62907GenBank Protein Database386422IUPHAR405Guide to Pharmacology405UniProtKBP47869UniProt AccessionGBRA2_HUMAN
synonyms:GABA(A) receptor subunit alpha-2
amino-acid-sequence:>lcl|BSEQ0037005|Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
gene-sequence:>lcl|BSEQ0010268|Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) ATGAAGACAAAATTGAACATCTACAACATGCAGTTCCTGCTTTTTGTTTTCTTGGTGTGG GACCCTGCCAGGTTGGTGCTGGCTAACATCCAAGAAGATGAGGCTAAAAATAACATTACC ATCTTTACGAGAATTCTTGACAGACTTCTGGATGGTTACGATAATCGGCTTAGACCAGGA CTGGGAGACAGTATTACTGAAGTCTTCACTAACATCTACGTGACCAGTTTTGGCCCTGTC TCAGATACAGATATGGAATATACAATTGATGTTTTCTTTCGACAAAAATGGAAAGATGAA CGTTTAAAATTTAAAGGTCCTATGAATATCCTTCGACTAAACAATTTAATGGCTAGCAAA ATCTGGACTCCAGATACCTTTTTTCACAATGGGAAAAAATCAGTAGCTCATAATATGACA ATGCCAAATAAGTTGCTTCGAATTCAGGATGATGGGACTCTGCTGTATACCATGAGGCTT ACAGTTCAAGCTGAATGCCCAATGCACTTGGAGGATTTCCCAATGGATGCTCATTCATGT CCTCTGAAATTTGGCAGCTATGCATATACAACTTCAGAGGTCACTTATATTTGGACTTAC AATGCATCTGATTCAGTACAGGTTGCTCCTGATGGCTCTAGGTTAAATCAATATGACCTG CTGGGCCAATCAATCGGAAAGGAGACAATTAAATCCAGTACAGGTGAATATACTGTAATG ACAGCTCATTTCCACCTGAAAAGAAAAATTGGGTATTTTGTGATTCAAACCTATCTGCCT TGCATCATGACTGTCATTCTCTCCCAAGTTTCATTCTGGCTTAACAGAGAATCTGTGCCT GCAAGAACTGTGTTTGGAGTAACAACTGTCCTAACAATGACAACTCTAAGCATCAGTGCT CGGAATTCTCTCCCCAAAGTGGCTTATGCAACTGCCATGGACTGGTTTATTGCTGTTTGT TATGCATTTGTGTTCTCTGCCCTAATTGAATTTGCAACTGTTAATTACTTCACCAAAAGA GGATGGGCTTGGGATGGGAAGAGTGTAGTAAATGACAAGAAAAAAGAAAAGGCTTCCGTT ATGATACAGAACAACGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAA GATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGAAGCCA GAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATG TCCAGAATAGTTTTTCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATAT TTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentaxoncomponentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentintegral component of synaptic vesicle membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessneurotransmitter transportprocessregulation of membrane potentialprocessregulation of neurotransmitter levelsprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transport
name:Gamma-aminobutyric acid receptor subunit alpha-3
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA3
locus:Xq28
cellular-location:Cell junction
transmembrane-regions:277-298 304-325 338-359 458-479
signal-regions:1-28
theoretical-pi:8.93
molecular-weight:55164.055
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4077GenAtlasGABRA3GenBank Gene DatabaseS62908GenBank Protein Database386424IUPHAR406Guide to Pharmacology406UniProtKBP34903UniProt AccessionGBRA3_HUMAN
synonyms:GABA(A) receptor subunit alpha-3
amino-acid-sequence:>lcl|BSEQ0016119|Gamma-aminobutyric acid receptor subunit alpha-3 MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRL NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN YFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN RESAIKGMIRKQ
gene-sequence:>lcl|BSEQ0016120|Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3) ATGATAATCACACAAACAAGTCACTGTTACATGACCAGCCTTGGGATTCTTTTCCTGATT AATATTCTCCCTGGAACCACTGGTCAAGGGGAATCAAGACGACAAGAACCCGGGGACTTT GTGAAGCAGGACATTGGCGGGCTGTCTCCTAAGCATGCCCCAGATATTCCTGATGACAGC ACTGACAACATCACTATCTTCACCAGAATCTTGGATCGTCTTCTGGACGGCTATGACAAC CGGCTGCGACCTGGGCTTGGAGATGCAGTGACTGAAGTGAAGACTGACATCTACGTGACC AGTTTTGGCCCTGTGTCAGACACTGACATGGAGTACACTATTGATGTATTTTTTCGGCAG ACATGGCATGATGAAAGACTGAAATTTGATGGCCCCATGAAGATCCTTCCACTGAACAAT CTCCTGGCTAGTAAGATCTGGACACCGGACACCTTCTTCCACAATGGCAAGAAATCAGTG GCTCATAACATGACCACGCCCAACAAGCTGCTCAGATTGGTGGACAACGGAACCCTCCTC TATACAATGAGGTTAACAATTCATGCTGAGTGTCCCATGCATTTGGAAGATTTTCCCATG GATGTGCATGCCTGCCCACTGAAGTTTGGAAGCTATGCCTATACAACAGCTGAAGTGGTT TATTCTTGGACTCTCGGAAAGAACAAATCCGTGGAAGTGGCACAGGATGGTTCTCGCTTG AACCAGTATGACCTTTTGGGCCATGTTGTTGGGACAGAGATAATCCGGTCTAGTACAGGA GAATATGTCGTCATGACAACCCACTTCCATCTCAAGCGAAAAATTGGCTACTTTGTGATC CAGACCTACTTGCCATGTATCATGACTGTCATTCTGTCACAAGTGTCGTTCTGGCTCAAC AGAGAGTCTGTTCCTGCCCGTACAGTCTTTGGTGTCACCACTGTGCTTACCATGACCACC TTGAGTATCAGTGCCAGAAATTCCTTACCTAAAGTGGCATATGCGACGGCCATGGACTGG TTCATAGCCGTCTGTTATGCCTTTGTATTTTCTGCACTGATTGAATTTGCCACTGTCAAC TATTTCACCAAGCGGAGTTGGGCTTGGGAAGGCAAGAAGGTGCCAGAGGCCCTGGAGATG AAGAAGAAAACACCAGCAGCCCCAGCAAAGAAAACCAGCACTACCTTCAACATCGTGGGG ACCACCTATCCCATCAACCTGGCCAAGGACACTGAATTTTCCACCATCTCCAAGGGCGCT GCTCCCAGTGCCTCCTCAACCCCAACAATCATTGCTTCACCCAAGGCCACCTACGTGCAG GACAGCCCGACTGAGACCAAGACCTACAACAGTGTCAGCAAGGTTGACAAAATTTCCCGC ATCATCTTTCCTGTGCTCTTTGCCATATTCAATCTGGTCTATTGGGCCACATATGTCAAC CGGGAGTCAGCTATCAAGGGCATGATCCGCAAACAGTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-5
general-function:Transporter activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA5
locus:15q11.2-q12
cellular-location:Cell junction
transmembrane-regions:260-281 286-307 319-341 428-449
signal-regions:1-31
theoretical-pi:9.56
molecular-weight:52145.645
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4079GenAtlasGABRA5GenBank Gene DatabaseL08485GenBank Protein Database182916IUPHAR408Guide to Pharmacology408UniProtKBP31644UniProt AccessionGBRA5_HUMAN
synonyms:GABA(A) receptor subunit alpha-5
amino-acid-sequence:>lcl|BSEQ0010331|Gamma-aminobutyric acid receptor subunit alpha-5 MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
gene-sequence:>lcl|BSEQ0010332|Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) ATGGACAATGGAATGTTCTCTGGTTTTATCATGATCAAAAACCTCCTTCTCTTTTGTATT TCCATGAACTTATCCAGTCACTTTGGCTTTTCACAGATGCCAACCAGTTCAGTGAAAGAT GAGACCAATGACAACATCACGATATTTACCAGGATCTTGGATGGGCTCTTGGATGGCTAC GACAACAGACTTCGGCCCGGGCTGGGAGAGCGCATCACTCAGGTGAGGACCGACATCTAC GTCACCAGCTTCGGCCCGGTGTCCGACACGGAAATGGAGTACACCATAGACGTGTTTTTC CGACAAAGCTGGAAAGATGAAAGGCTTCGGTTTAAGGGGCCCATGCAGCGCCTCCCTCTC AACAACCTCCTTGCCAGCAAGATCTGGACCCCAGACACGTTCTTCCACAACGGGAAGAAG TCCATCGCTCACAACATGACCACGCCCAACAAGCTGCTGCGGCTGGAGGACGACGGCACC CTGCTCTACACCATGCGCTTGACCATCTCTGCAGAGTGCCCCATGCAGCTTGAGGACTTC CCGATGGATGCGCACGCTTGCCCTCTGAAATTTGGCAGCTATGCGTACCCTAATTCTGAA GTCGTTTACGTCTGGACCAACGGCTCCACCAAGTCGGTGGTGGTGGCGGAAGATGGCTCC AGACTGAACCAGTACCACCTGATGGGGCAGACGGTGGGCACTGAGAACATCAGCACCAGC ACAGGCGAATACACAATCATGACAGCTCACTTCCACCTGAAAAGGAAGATTGGCTACTTT GTCATCCAGACCTACCTTCCCTGCATAATGACCGTGATCTTATCACAGGTGTCCTTTTGG CTGAACCGGGAATCAGTCCCAGCCAGGACAGTTTTTGGGGTCACCACGGTGCTGACCATG ACGACCCTCAGCATCAGCGCCAGGAACTCTCTGCCCAAAGTGGCCTACGCCACCGCCATG GACTGGTTCATAGCCGTGTGCTATGCCTTCGTCTTCTCGGCGCTGATAGAGTTTGCCACG GTCAATTACTTTACCAAGAGAGGCTGGGCCTGGGATGGCAAAAAAGCCTTGGAAGCAGCC AAGATCAAGAAAAAGCGTGAAGTCATACTAAATAAGTCAACAAACGCTTTTACAACTGGG AAGATGTCTCACCCCCCAAACATTCCGAAGGAACAGACCCCAGCAGGGACGTCGAATACA ACCTCAGTCTCAGTAAAACCCTCTGAAGAGAAGACTTCTGAAAGCAAAAAGACTTACAAC AGTATCAGCAAAATTGACAAAATGTCCCGAATCGTATTCCCAGTCTTGTTCGGCACTTTC AACTTAGTTTACTGGGCAACGTATTTGAATAGGGAGCCGGTGATAAAAGGAGCCGCCTCT CCAAAATAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentdendritecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentneuronal cell body membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityfunctionreceptor activityfunctiontransporter activityprocessassociative learningprocessbehavioral fear responseprocessbrain developmentprocesschloride transmembrane transportprocesscochlea developmentprocessgamma-aminobutyric acid signaling pathwayprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessmitophagy in response to mitochondrial depolarizationprocessnegative regulation of neuron apoptotic processprocessneurological system processprocesspositive regulation of defense response to virus by hostprocessregulation of membrane potentialprocessresponse to drugprocesssensory perception of soundprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransportprocessxenophagy
name:Gamma-aminobutyric acid receptor subunit gamma-1
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRG1
locus:4p12
cellular-location:Cell junction
transmembrane-regions:273-294 299-320 332-354 445-465
signal-regions:1-35
theoretical-pi:8.23
molecular-weight:53594.49
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4086GenBank Gene DatabaseAK122845GenBank Protein Database193783776UniProtKBQ8N1C3UniProt AccessionGBRG1_HUMAN
synonyms:GABA(A) receptor subunit gamma-1
amino-acid-sequence:>lcl|BSEQ0012496|Gamma-aminobutyric acid receptor subunit gamma-1 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
gene-sequence:>lcl|BSEQ0012497|Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1) ATGGGTCCTTTGAAAGCTTTTCTCTTCTCCCCTTTTCTTCTGCGGAGTCAAAGTAGAGGG GTGAGGTTGGTCTTCTTGTTACTGACCCTGCATTTGGGAAACTGTGTTGATAAGGCAGAT GATGAAGATGATGAGGATTTAACGGTGAACAAAACCTGGGTCTTGGCCCCAAAAATTCAT GAAGGAGATATCACACAAATTCTGAATTCATTGCTTCAAGGCTATGACAATAAACTTCGT CCAGATATAGGAGTGAGGCCCACAGTAATTGAAACTGATGTTTATGTAAACAGCATTGGA CCAGTTGATCCAATTAATATGGAATATACAATAGATATAATTTTTGCCCAAACCTGGTTT GACAGTCGTTTAAAATTCAATAGTACCATGAAAGTGCTTATGCTTAACAGTAATATGGTT GGAAAAATTTGGATTCCTGACACTTTCTTCAGAAACTCAAGAAAATCTGATGCTCACTGG ATAACAACTCCTAATCGTCTGCTTCGAATTTGGAATGATGGACGAGTTCTGTATACTCTA AGATTGACAATTAATGCAGAATGTTATCTTCAGCTTCATAACTTTCCCATGGATGAACAT TCCTGTCCACTGGAATTTTCAAGCTATGGATACCCTAAAAATGAAATTGAGTATAAGTGG AAAAAGCCCTCCGTAGAAGTGGCTGATCCTAAATACTGGAGATTATATCAGTTTGCATTT GTAGGGTTACGGAACTCAACTGAAATCACTCACACGATCTCTGGGGATTATGTTATCATG ACAATTTTTTTTGACCTGAGCAGAAGAATGGGATATTTCACTATTCAGACCTACATTCCA TGCATTCTGACAGTTGTTCTTTCTTGGGTGTCTTTTTGGATCAATAAAGATGCAGTGCCT GCAAGAACATCGTTGGGTATCACTACAGTTCTGACTATGACAACCCTGAGTACAATTGCC AGGAAGTCTTTACCTAAGGTTTCTTATGTGACTGCGATGGATCTCTTTGTTTCTGTTTGT TTCATTTTTGTTTTTGCAGCCTTGATGGAATATGGAACCTTGCATTATTTTACCAGCAAC CAAAAAGGAAAGACTGCTACTAAAGACAGAAAGCTAAAAAATAAAGCCTCGATGACTCCT GGTCTCCATCCTGGATCCACTCTGATTCCAATGAATAATATTTCTGTGCCGCAAGAAGAT GATTATGGGTATCAGTGTTTGGAGGGCAAAGATTGTGCCAGCTTCTTCTGTTGCTTTGAA GACTGCAGAACAGGATCTTGGAGGGAAGGAAGGATACACATACGCATTGCCAAAATTGAC TCTTATTCTAGAATATTTTTCCCAACCGCTTTTGCCCTGTTCAACTTGGTTTATTGGGTT GGCTATCTTTACTTATAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmission
name:Gamma-aminobutyric acid receptor subunit gamma-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
gene-name:GABRG2
locus:5q31.1-q33.1
cellular-location:Cell junction
transmembrane-regions:274-296 300-322 334-356 444-466
signal-regions:1-39
theoretical-pi:8.6
molecular-weight:54161.78
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4087GenBank Gene DatabaseX15376GenBank Protein Database31637UniProtKBP18507UniProt AccessionGBRG2_HUMAN
synonyms:GABA(A) receptor subunit gamma-2
amino-acid-sequence:>lcl|BSEQ0006917|Gamma-aminobutyric acid receptor subunit gamma-2 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
gene-sequence:>lcl|BSEQ0019445|Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) ATGAGTTCGCCAAATATATGGAGCACAGGAAGCTCAGTCTACTCGACTCCTGTATTTTCA CAGAAAATGACGGTGTGGATTCTGCTCCTGCTGTCGCTCTACCCTGGCTTCACTAGCCAG AAATCTGATGATGACTATGAAGATTATGCTTCTAACAAAACATGGGTCTTGACTCCAAAA GTTCCTGAGGGTGATGTCACTGTCATCTTAAACAACCTGCTGGAAGGATATGACAATAAA CTTCGGCCTGATATAGGAGTGAAGCCAACGTTAATTCACACAGACATGTATGTGAATAGC ATTGGTCCAGTGAACGCTATCAATATGGAATACACTATTGATATATTTTTTGCGCAAACG TGGTATGACAGACGTTTGAAATTTAACAGCACCATTAAAGTCCTCCGATTGAACAGCAAC ATGGTGGGGAAAATCTGGATTCCAGACACTTTCTTCAGAAATTCCAAAAAAGCTGATGCA CACTGGATCACCACCCCCAACAGGATGCTGAGAATTTGGAATGATGGTCGAGTGCTCTAC ACCCTAAGGTTGACAATTGATGCTGAGTGCCAATTACAATTGCACAACTTTCCAATGGAT GAACACTCCTGCCCCTTGGAGTTCTCCAGTTATGGCTATCCACGTGAAGAAATTGTTTAT CAATGGAAGCGAAGTTCTGTTGAAGTGGGCGACACAAGATCCTGGAGGCTTTATCAATTC TCATTTGTTGGTCTAAGAAATACCACCGAAGTAGTGAAGACAACTTCCGGAGATTATGTG GTCATGTCTGTCTACTTTGATCTGAGCAGAAGAATGGGATACTTTACCATCCAGACCTAT ATCCCCTGCACACTCATTGTCGTCCTATCCTGGGTGTCTTTCTGGATCAATAAGGATGCT GTTCCAGCCAGAACATCTTTAGGTATCACCACTGTCCTGACAATGACCACCCTCAGCACC ATTGCCCGGAAATCGCTCCCCAAGGTCTCCTATGTCACAGCGATGGATCTCTTTGTATCT GTTTGTTTCATCTTTGTCTTCTCTGCTCTGGTGGAGTATGGCACCTTGCATTATTTTGTC AGCAACCGGAAACCAAGCAAGGACAAAGATAAAAAGAAGAAAAACCCTGCCCCTACCATT GATATCCGCCCAAGATCAGCAACCATTCAAATGAATAATGCTACACACCTTCAAGAGAGA GATGAAGAGTACGGCTATGAGTGTCTGGACGGCAAGGACTGTGCCAGTTTTTTCTGCTGT TTTGAAGATTGTCGAACAGGAGCTTGGAGACATGGGAGGATACATATCCGCATTGCCAAA ATGGACTCCTATGCTCGGATCTTCTTCCCCACTGCCTTCTGCCTGTTTAATCTGGTCTAT TGGGTCTCCTACCTCTACCTGTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentaxoncomponentcell junctioncomponentchloride channel complexcomponentdendrite membranecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocessadult behaviorprocesscellular response to histamineprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocesspost-embryonic developmentprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit gamma-3
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRG3
locus:15q12
cellular-location:Cell junction
transmembrane-regions:255-277 281-303 315-337 444-467
signal-regions:1-17
theoretical-pi:7.58
molecular-weight:54288.16
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4088GenBank Gene DatabaseS82769GenBank Protein Database1754749UniProtKBQ99928UniProt AccessionGBRG3_HUMAN
synonyms:GABA(A) receptor subunit gamma-3
amino-acid-sequence:>lcl|BSEQ0006921|Gamma-aminobutyric acid receptor subunit gamma-3 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDK KLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNS NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPM DEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDY VVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLS TIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDS SRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
gene-sequence:>lcl|BSEQ0012498|Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3) ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGA AAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCA AAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAAC AGCATTGGTCCTGTGTCATCAATAAACATGGAATACCAAATTGACATATTTTTTGCTCAG ACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGC AACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAG GCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTT TACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATG GACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATT TATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAG TTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTAGGAAT TTACTGAAAGAGGCACAGCTCTCAAAAGCCAGAGAGGCCTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transport
BE0002638Cytochrome P450 3A4HumanssubstrateA1650210359672Shou M, Mei Q, Ettore MW Jr, Dai R, Baillie TA, Rushmore TH: Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J. 1999 Jun 15;340 ( Pt 3):845-53.unknownCytochrome P450 3A4Vitamin d3 25-hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).CYP3A47q21.1Endoplasmic reticulum membrane2-228.2557342.677HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2637GenAtlasCYP3A4GenBank Gene DatabaseM18907Guide to Pharmacology1337UniProtKBP08684UniProt AccessionCP3A4_HUMAN1,8-cineole 2-exo-monooxygenase1.14.13.-Albendazole monooxygenaseAlbendazole sulfoxidaseCholesterol 25-hydroxylaseCYP3A3CYPIIIA3CYPIIIA4Cytochrome P450 3A3Cytochrome P450 HLpCytochrome P450 NF-25Cytochrome P450-PCN1Nifedipine oxidaseQuinine 3-monooxygenaseTaurochenodeoxycholate 6-alpha-hydroxylase>lcl|BSEQ0021936|Cytochrome P450 3A4 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG GLLQPEKPVVLKVESRDGTVSGA>lcl|BSEQ0021937|Cytochrome P450 3A4 (CYP3A4) ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG CTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG CCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTT GACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCT GTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT GTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATA GCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGA AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGC ATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTT CTCTCAATAATCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTGTTT CCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGCCTC GAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAATTCA AAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATTATC TTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTG GCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAAT AAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAAT GAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTT GAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTT CACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAG AAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAAC TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGAGGA CTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTAAGT GGAGCCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintegral component of membranecomponentintracellular membrane-bounded organellefunctionalbendazole monooxygenase activityfunctionaromatase activityfunctioncaffeine oxidase activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxygen bindingfunctionquinine 3-monooxygenase activityfunctionsteroid bindingfunctionsteroid hydroxylase activityfunctiontaurochenodeoxycholate 6alpha-hydroxylase activityfunctiontestosterone 6-beta-hydroxylase activityfunctionvitamin D 24-hydroxylase activityfunctionvitamin D3 25-hydroxylase activityprocessalkaloid catabolic processprocessandrogen metabolic processprocesscalcitriol biosynthetic process from calciolprocessdrug catabolic processprocessdrug metabolic processprocessexogenous drug catabolic processprocessheterocycle metabolic processprocesslipid metabolic processprocessmonoterpenoid metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid catabolic processprocesssteroid metabolic processprocessvitamin D metabolic processprocessxenobiotic metabolic processBE0003549Cytochrome P450 2B6HumanssubstrateA394268948091Ono S, Hatanaka T, Miyazawa S, Tsutsui M, Aoyama T, Gonzalez FJ, Satoh T: Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66. doi: 10.3109/00498259609050260.unknownCytochrome P450 2B6Steroid hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.CYP2B619q13.2Endoplasmic reticulum membrane8.4456277.8119HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2615GenBank Gene DatabaseM29874GenBank Protein Database181296Guide to Pharmacology1324UniProtKBP20813UniProt AccessionCP2B6_HUMAN1,4-cineole 2-exo-monooxygenase1.14.13.-CYPIIB6Cytochrome P450 IIB1>lcl|BSEQ0006839|Cytochrome P450 2B6 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI PPTYQIRFLPR>lcl|BSEQ0019435|Cytochrome P450 2B6 (CYP2B6) ATGGAACTCAGCGTCCTCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCCTGGTT CAGCGCCACCCTAACACCCATGACCGCCTCCCACCAGGGCCCCGCCCTCTGCCCCTTTTG GGAAACCTTCTGCAGATGGATAGAAGAGGCCTACTCAAATCCTTTCTGAGGTTCCGAGAG AAATATGGGGACGTCTTCACGGTACACCTGGGACCGAGGCCCGTGGTCATGCTGTGTGGA GTAGAGGCCATACGGGAGGCCCTTGTGGACAAGGCTGAGGCCTTCTCTGGCCGGGGAAAA ATCGCCATGGTCGACCCATTCTTCCGGGGATATGGTGTGATCTTTGCCAATGGAAACCGC TGGAAGGTGCTTCGGCGATTCTCTGTGACCACTATGAGGGACTTCGGGATGGGAAAGCGG AGTGTGGAGGAGCGGATTCAGGAGGAGGCTCAGTGTCTGATAGAGGAGCTTCGGAAATCC AAGGGGGCCCTCATGGACCCCACCTTCCTCTTCCAGTCCATTACCGCCAACATCATCTGC TCCATCGTCTTTGGAAAACGATTCCACTACCAAGATCAAGAGTTCCTGAAGATGCTGAAC TTGTTCTACCAGACTTTTTCACTCATCAGCTCTGTATTCGGCCAGCTGTTTGAGCTCTTC TCTGGCTTCTTGAAATACTTTCCTGGGGCACACAGGCAAGTTTACAAAAACCTGCAGGAA ATCAATGCTTACATTGGCCACAGTGTGGAGAAGCACCGTGAAACCCTGGACCCCAGCGCC CCCAAGGACCTCATCGACACCTACCTGCTCCACATGGAAAAAGAGAAATCCAACGCACAC AGTGAATTCAGCCACCAGAACCTCAACCTCAACACGCTCTCGCTCTTCTTTGCTGGCACT GAGACCACCAGCACCACTCTCCGCTACGGCTTCCTGCTCATGCTCAAATACCCTCATGTT GCAGAGAGAGTCTACAGGGAGATTGAACAGGTGATTGGCCCACATCGCCCTCCAGAGCTT CATGACCGAGCCAAAATGCCATACACAGAGGCAGTCATCTATGAGATTCAGAGATTTTCC GACCTTCTCCCCATGGGTGTGCCCCACATTGTCACCCAACACACCAGCTTCCGAGGGTAC ATCATCCCCAAGGACACAGAAGTATTTCTCATCCTGAGCACTGCTCTCCATGACCCACAC TACTTTGAAAAACCAGACGCCTTCAATCCTGACCACTTTCTGGATGCCAATGGGGCACTG AAAAAGACTGAAGCTTTTATCCCCTTCTCCTTAGGGAAGCGGATTTGTCTTGGTGAAGGC ATCGCCCGTGCGGAATTGTTCCTCTTCTTCACCACCATCCTCCAGAACTTCTCCATGGCC AGCCCCGTGGCCCCAGAAGACATCGATCTGACACCCCAGGAGTGTGGTGTGGGCAAAATA CCCCCAACATACCAGATCCGCTTCCTGCCCCGCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunctionarachidonic acid epoxygenase activityfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocesscellular ketone metabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessoxidation-reduction processprocesssmall molecule metabolic processprocesssteroid metabolic processprocessxenobiotic metabolic processBE0002793Cytochrome P450 2C9HumanssubstrateA1481311996015Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.unknownCytochrome P450 2C9Steroid hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.CYP2C910q24Endoplasmic reticulum membrane7.9955627.36510HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2623GenAtlasCYP2C9GenBank Gene DatabaseAY341248Guide to Pharmacology1326UniProtKBP11712UniProt AccessionCP2C9_HUMAN(R)-limonene 6-monooxygenase(S)-limonene 6-monooxygenase(S)-limonene 7-monooxygenase1.14.13.-Cholesterol 25-hydroxylaseCYP2C10CYPIIC9Cytochrome P-450MPCytochrome P450 MP-4Cytochrome P450 MP-8Cytochrome P450 PB-1S-mephenytoin 4-hydroxylase>lcl|BSEQ0005471|Cytochrome P450 2C9 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP PFYQLCFIPV>lcl|BSEQ0016893|Cytochrome P450 2C9 (CYP2C9) ATGGATTCTCTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCACTCTGG AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA AATATCCTACAGATAGGTATTAAGGACATCAGCAAATCCTTAACCAATCTCTCAAAGGTC TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGCTGCATGGATAT GAAGCAGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCATTTTC CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGG AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG GCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC ATTATTTTCCATAAACGTTTTGATTATAAAGATCAGCAATTTCTTAACTTAATGGAAAAG TTGAATGAAAACATCAAGATTTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCT CCTATCATTGATTACTTCCCGGGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATG AAAAGTTATATTTTGGAAAAAGTAAAAGAACACCAAGAATCAATGGACATGAACAACCCT CAGGACTTTATTGATTGCTTCCTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCT GAATTTACTATTGAAAGCTTGGAAAACACTGCAGTTGACTTGTTTGGAGCTGGGACAGAG ACGACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA GCTAAAGTCCAGGAAGAGATTGAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAA GACAGGAGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATTGAC CTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTCAGAAACTATCTC ATTCCCAAGGGCACAACCATATTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAA TTTCCCAACCCAGAGATGTTTGACCCTCATCACTTTCTGGATGAAGGTGGCAATTTTAAG AAAAGTAAATACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTG GCCGGCATGGAGCTGTTTTTATTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCT CTGGTTGACCCAAAGAACCTTGACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCG CCCTTCTACCAGCTGTGCTTCATTCCTGTCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunction(R)-limonene 6-monooxygenase activityfunction(S)-limonene 6-monooxygenase activityfunction(S)-limonene 7-monooxygenase activityfunctionarachidonic acid epoxygenase activityfunctionaromatase activityfunctioncaffeine oxidase activityfunctiondrug bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessarachidonic acid metabolic processprocesscellular amide metabolic processprocessdrug catabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessmonocarboxylic acid metabolic processprocessmonoterpenoid metabolic processprocessomega-hydroxylase P450 pathwayprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid metabolic processprocessurea metabolic processprocessxenobiotic metabolic process
载体
运输工具
药物反应
reactions:1
left-element--drugbank-id:DB00231
left-element--name:Temazepam
right-element--drugbank-id:DBMET00246
right-element--name:Oxazepam
enzymes--drugbank-id:BE0002638
enzymes--name:Cytochrome P450 3A4
enzymes--uniprot-id:P08684
enzymes--drugbank-id:BE0003536
enzymes--name:Cytochrome P450 2C19
enzymes--uniprot-id:P33261
reactions:1
left-element--drugbank-id:DB00231
left-element--name:Temazepam
right-element--drugbank-id:DBMET00650
right-element--name:Oxazepam glucuronide
效应
不良反应