描述
An antineoplastic agent that acts by alkylation.
指示
For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
药效学
Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
作用机制
The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.
毒性
Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.
吸收
Well absorbed from the GI tract.
分类
description:This compound belongs to the class of organic compounds known as piperazines. These are compounds containing a piperazine ring, which is a saturated aliphatic six-member heterocyclic with two nitrogen atoms at positions 1 and 4, as well as four carbon atoms.
direct-parent:Piperazines
kingdom:Organic compounds
superclass:Organoheterocyclic compounds
class:Diazinanes
subclass:Piperazines
alternative-parent:Alkyl bromides
alternative-parent:Azacyclic compounds
alternative-parent:Carbonyl compounds
alternative-parent:Hydrocarbon derivatives
alternative-parent:Organic oxides
alternative-parent:Organobromides
alternative-parent:Organonitrogen compounds
alternative-parent:Organopnictogen compounds
alternative-parent:Tertiary carboxylic acid amides
substituent:Aliphatic heteromonocyclic compound
substituent:Alkyl bromide
substituent:Alkyl halide
substituent:Azacycle
substituent:Carbonyl group
substituent:Carboxamide group
substituent:Carboxylic acid derivative
substituent:Hydrocarbon derivative
substituent:Organic nitrogen compound
substituent:Organic oxide
substituent:Organic oxygen compound
substituent:Organobromide
substituent:Organohalogen compound
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound
substituent:Piperazine
substituent:Tertiary carboxylic acid amide
种类
Alkylating Drugs
D000477
Antineoplastic Agents
D000970
Antineoplastic Agents, Alkylating
D018906
Antineoplastic and Immunomodulating Agents
Noxae
D009676
Piperazines
D010879
Toxic Actions
D004786
同义词
language:english; code:; name;1,4-bis(3-bromopropionyl)piperazine
language:english; code:; name;N,N-bis-(3-bromopropionyl)-piperazine
language:english; code:inn; name;Pipobroman
language:latin; code:inn; name;Pipobromanum
国际品牌
VerciteAbbott LaboratoriesVercyteAbbott Laboratories
generic:否; url:; name;Abbott laboratories pharmaceutical products div
受影响的生物体
Humans and other mammals
剂量
form:Tablet
route:
strength:10 MG
form:Tablet
route:
strength:25 MG
atc代码
Other alkylating agents
ALKYLATING AGENTS
ANTINEOPLASTIC AGENTS
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
药物相互作用
DB00012The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pipobroman.
DB00016The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Pipobroman.
DB08894The risk or severity of Thrombosis can be increased when Peginesatide is combined with Pipobroman.
DB09107The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pipobroman.
实验性质
Water Solubility
2490 mg/L
Melting Point
> 300 °C
PhysProp
logP
0.42
HANSCH,C ET AL. (1995)
resource：ChEBI
identifier：8242
resource：PubChem Compound
identifier：4842
resource：PubChem Substance
identifier：46506548
resource：KEGG Compound
identifier：C07362
resource：KEGG Drug
identifier：D00467
resource：ChemSpider
identifier：4676
resource：PharmGKB
identifier：PA164747673
resource：Therapeutic Targets Database
identifier：DAP000988
resource：Wikipedia
identifier：Pipobroman
resource：ChEMBL
identifier：CHEMBL1585
resource：ZINC
identifier：ZINC000001530753
resource：RxCUI
identifier：8347
目标
id:BE0004796
name:DNA
organism:Humans
action:cross-linking/alkylation
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Yellin TO: Effects of piposulfan (Ancyte) on protein and DNA synthesis in Ehrlich ascites carcinoma. Life Sci II. 1971 Jun 8;10(11):605-12.
Passamonti F, Lazzarino M: Treatment of polycythemia vera and essential thrombocythemia: the role of pipobroman. Leuk Lymphoma. 2003 Sep;44(9):1483-8.
known-action:yes