ID

DB00239|APRD01154||

名称

Oxiconazole

描述

Oxiconazole is an antifungal agent that is commonly found in topical formulations. It is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin infections such as athlete's foot, jock itch and ringworm.

cas号

64211-45-6

唯一标识码

C668Q9I33J

状态

solid

组

approved,

指示

For treatment of dermal fungal infection.

药效学

Oxiconazole is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has fungicidal or fungistatic activity in vitro against a number of pathogenic fungi including the following dermatophytes, and yeasts: T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur.

作用机制

Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.

毒性

Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.

代谢

吸收

Systemic absorption of oxiconazole is low.

半衰期

分类

description:This compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
direct-parent:Dichlorobenzenes
kingdom:Organic compounds
superclass:Benzenoids
class:Benzene and substituted derivatives
subclass:Halobenzenes
alternative-parent:Aryl chlorides
alternative-parent:Azacyclic compounds
alternative-parent:Heteroaromatic compounds
alternative-parent:Hydrocarbon derivatives
alternative-parent:N-substituted imidazoles
alternative-parent:Organochlorides
alternative-parent:Organonitrogen compounds
alternative-parent:Organooxygen compounds
alternative-parent:Organopnictogen compounds
substituent:1,3-dichlorobenzene
substituent:Aromatic heteromonocyclic compound
substituent:Aryl chloride
substituent:Aryl halide
substituent:Azacycle
substituent:Azole
substituent:Heteroaromatic compound
substituent:Hydrocarbon derivative
substituent:Imidazole
substituent:N-substituted imidazole
substituent:Organic nitrogen compound
substituent:Organic oxygen compound
substituent:Organochloride
substituent:Organohalogen compound
substituent:Organoheterocyclic compound
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound

消除途径

种类

Anti-Infective Agents
D000890
Antifungal Agents
D000935
Antifungals for Dermatological Use

Antifungals for Topical Use

Azole Antifungals

Cytochrome P-450 CYP2C19 Substrates

Cytochrome P-450 CYP3A Inducers
D065701
Cytochrome P-450 CYP3A4 Inducers
D065701
Cytochrome P-450 CYP3A4 Inducers (strength unknown)

Cytochrome P-450 Enzyme Inducers
D065693
Cytochrome P-450 Substrates

Dermatologicals
D003879
Genito Urinary System and Sex Hormones

Gynecological Antiinfectives and Antiseptics

Imidazole and Triazole Derivatives

Imidazole Derivatives

盐类

DBSALT000892Oxiconazole nitrateRQ8UL4C17S64211-46-7WVNOAGNOIPTWPT-NDUABGMUSA-N492.13489.9769157

蛋白质结合

清除

同义词

language:english; code:; name;2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-[O-(2,4-dichlorobenzyl)oxime]
language:spanish; code:inn; name;Oxiconazol
language:english/french; code:inn; name;Oxiconazole
language:latin; code:inn; name;Oxiconazolum

国际品牌

配送量

产品

name:Oxiconazole Nitrate
labeller:E. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
ndc-id:
ndc-product-code:0168-0358
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-03-09
ended-marketing-on:
dosage-form:Cream
strength:10 mg/1g
route:Topical
fda-application-number:NDA019828
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxiconazole Nitrate
labeller:Taro Pharmaceuticals U.S.A., Inc.
ndc-id:
ndc-product-code:51672-1359
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-03-07
ended-marketing-on:
dosage-form:Cream
strength:10 mg/1g
route:Topical
fda-application-number:ANDA205076
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxiconazole Nitrate Cream 1%
labeller:Welgo, Llc
ndc-id:
ndc-product-code:70263-333
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2016-08-01
ended-marketing-on:2017-12-31
dosage-form:Cream
strength:10 mg/1g
route:Topical
fda-application-number:ANDA205076
generic:true
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxistat
labeller:Rebel Distributors
ndc-id:
ndc-product-code:21695-459
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2006-01-25
ended-marketing-on:
dosage-form:Lotion
strength:30 mg/1g
route:Topical
fda-application-number:NDA020209
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxistat
labeller:Glaxosmithkline Inc
ndc-id:
ndc-product-code:0173-0448
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2006-02-02
ended-marketing-on:2011-02-11
dosage-form:Lotion
strength:10 mg/1mL
route:Topical
fda-application-number:NDA020209
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxistat
labeller:Glaxosmithkline Inc
ndc-id:
ndc-product-code:0173-0423
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2006-02-02
ended-marketing-on:2011-12-31
dosage-form:Cream
strength:10 mg/1g
route:Topical
fda-application-number:NDA019828
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxistat
labeller:Pharma Derm, A Division Of Fougera Pharmaceuticals Inc.
ndc-id:
ndc-product-code:0462-0358
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2006-01-25
ended-marketing-on:2012-10-25
dosage-form:Cream
strength:10 mg/1g
route:Topical
fda-application-number:NDA019828
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxistat
labeller:Pharma Derm, A Division Of Fougera Pharmaceuticals Inc.
ndc-id:
ndc-product-code:0462-0359
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:2006-01-25
ended-marketing-on:2012-12-04
dosage-form:Lotion
strength:10 mg/1g
route:Topical
fda-application-number:NDA020209
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxistat
labeller:PharmaDerm a division of Fougera Pharmaceuticals Inc.
ndc-id:
ndc-product-code:10337-358
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1988-12-30
ended-marketing-on:
dosage-form:Cream
strength:10 mg/1g
route:Topical
fda-application-number:NDA019828
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxistat
labeller:PharmaDerm a division of Fougera Pharmaceuticals Inc.
ndc-id:
ndc-product-code:10337-359
dpd-id:
ema-product-code:
ema-ma-number:
started-marketing-on:1992-09-30
ended-marketing-on:
dosage-form:Lotion
strength:10 mg/1mL
route:Topical
fda-application-number:NDA020209
generic:false
over-the-counter:false
approved:true
country:US
source:FDA NDC
name:Oxizole
labeller:Valeo Pharma Corp.
ndc-id:
ndc-product-code:
dpd-id:02230452
ema-product-code:
ema-ma-number:
started-marketing-on:1998-05-21
ended-marketing-on:2006-07-31
dosage-form:Cream
strength:
route:Topical
fda-application-number:
generic:false
over-the-counter:true
approved:true
country:Canada
source:DPD
name:Oxizole
labeller:Stiefel Laboratories, Inc.
ndc-id:
ndc-product-code:
dpd-id:02230453
ema-product-code:
ema-ma-number:
started-marketing-on:1998-05-21
ended-marketing-on:2002-04-02
dosage-form:Lotion
strength:
route:Topical
fda-application-number:
generic:false
over-the-counter:true
approved:true
country:Canada
source:DPD

混合物

name:Oxistat
ingredients:Oxiconazole
name:Oxistat
ingredients:Oxiconazole
name:Oxistat
ingredients:Oxiconazole
name:Oxistat
ingredients:Oxiconazole
name:Oxistat
ingredients:Oxiconazole
name:Oxiconazole Nitrate
ingredients:Oxiconazole
name:Oxistat
ingredients:Oxiconazole
name:Oxistat
ingredients:Oxiconazole
name:Oxiconazole Nitrate
ingredients:Oxiconazole
name:Oxiconazole Nitrate Cream 1%
ingredients:Oxiconazole
name:Oxizole
ingredients:Oxiconazole
name:Oxizole
ingredients:Oxiconazole

包装者

name:Dispensing Solutions
url:http://www.drxdispensing.com
name:GlaxoSmithKline Inc.
url:http://www.gsk.com
name:Nycomed Inc.
url:http://www.nycomed.com
name:Pharmaderm
url:http://www.pharmaderm.com
name:Rebel Distributors Corp.
url:http://www.rebelrx.com

生产者

generic:否; url:; name;Altana inc

价格

Oxistat 1% cream
2.23(单位：USD）
g
Oxistat 1% Cream 15 gm Tube
48.99(单位：USD）
tube
Oxistat 1% Cream 30 gm Tube
90.31(单位：USD）
tube
Oxistat 1% Lotion 30ml Bottle
93.13(单位：USD）
bottle
Oxistat 1% Cream 60 gm Tube
157.99(单位：USD）
tube

受影响的生物体

Fungi

剂量

form:Spray
route:Topical
strength:1 %
form:Cream
route:Topical
strength:1 %
form:Cream
route:Topical
strength:10 mg/1g
form:Lotion
route:Topical
strength:10 mg/1g
form:Lotion
route:Topical
strength:10 mg/1mL
form:Lotion
route:Topical
strength:30 mg/1g
form:Cream
route:Topical
strength:
form:Lotion
route:Topical
strength:

atc代码

Imidazole and triazole derivatives
ANTIFUNGALS FOR TOPICAL USE
ANTIFUNGALS FOR DERMATOLOGICAL USE
DERMATOLOGICALS
Imidazole derivatives
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
GENITO URINARY SYSTEM AND SEX HORMONES
Imidazole derivatives
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
GENITO URINARY SYSTEM AND SEX HORMONES

fda标签

//s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00239.pdf?1265922815

化学品安全技术说明书

//s3-us-west-2.amazonaws.com/drugbank/msds/DB00239.pdf?1265922751

专利

食物相互作用

药物相互作用

DB14583
The metabolism of Segesterone acetate can be increased when combined with Oxiconazole.
DB11951
The serum concentration of Lemborexant can be decreased when it is combined with Oxiconazole.
DB06077
The serum concentration of Lumateperone can be decreased when it is combined with Oxiconazole.
DB00243
The metabolism of Ranolazine can be increased when combined with Oxiconazole.
DB01190
The metabolism of Clindamycin can be increased when combined with Oxiconazole.
DB12457
The metabolism of Rimegepant can be increased when combined with Oxiconazole.
DB11791
The serum concentration of Capmatinib can be decreased when it is combined with Oxiconazole.
DB15685
The serum concentration of Selpercatinib can be decreased when it is combined with Oxiconazole.
DB14881
The serum concentration of Oliceridine can be decreased when it is combined with Oxiconazole.

序列

实验性质

外部标识符

resource：Drugs Product Database (DPD)
identifier：11326
resource：ChEBI
identifier：7825
resource：PubChem Compound
identifier：5353853
resource：PubChem Substance
identifier：46504752
resource：KEGG Compound
identifier：C08074
resource：KEGG Drug
identifier：D08313
resource：ChemSpider
identifier：4510239
resource：BindingDB
identifier：50051844
resource：PharmGKB
identifier：PA164754742
resource：Therapeutic Targets Database
identifier：DAP001204
resource：Wikipedia
identifier：Oxiconazole
resource：ChEMBL
identifier：CHEMBL1262
resource：ZINC
identifier：ZINC000003873295
resource：RxCUI
identifier：32638

外部链接

RxList
http://www.rxlist.com/cgi/generic3/oxico.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/oxi1314.shtml
Drugs.com
http://www.drugs.com/cdi/oxiconazole-cream.html

路径

目标

id:BE0000233
name:Cytochrome P450 51
organism:Yeast
action:inhibitor
Carrillo-Munoz AJ, Giusiano G, Ezkurra PA, Quindos G: Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9.
Rossello A, Bertini S, Lapucci A, Macchia M, Martinelli A, Rapposelli S, Herreros E, Macchia B: Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. J Med Chem. 2002 Oct 24;45(22):4903-12.
known-action:yes
name:Lanosterol 14-alpha demethylase
general-function:Sterol 14-demethylase activity
specific-function:Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
gene-name:ERG11
locus:
cellular-location:Membrane
transmembrane-regions:
signal-regions:
theoretical-pi:7.19
molecular-weight:60674.965
chromosome-location:
organism:Yeast
external-identifiers:GenBank Gene DatabaseX13296GenBank Protein Database578119UniProtKBP10613UniProt AccessionCP51_CANAL
synonyms:1.14.13.70CYP51CYPLICytochrome P450 51Cytochrome P450-14DMCytochrome P450-LIA1ERG16Sterol 14-alpha demethylase
amino-acid-sequence:>lcl|BSEQ0010022|Lanosterol 14-alpha demethylase MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGS AASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKH LTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKE KTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPL PHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANL LIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLP SVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPE DFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL GTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRETCMF
gene-sequence:>lcl|BSEQ0010023|Lanosterol 14-alpha demethylase (ERG11) ATGGCTATTGTTGAAACTGTCATTGATGGCATTAATTATTTTTTGTCCCTTAGTGTTACA CAACAGATCAGTATATTATTAGGGGTTCCATTTGTTTACAACTTAGTATGGCAATATTTA TATTCATTAAGAAAAGATAGAGCTCCATTAGTGTTTTATTGGATTCCTTGGTTTGGTTCT GCAGCTTCATATGGTCAACAACCTTATGAATTTTTCGAATCATGTCGTCAAAAGTATGGT GATGTATTTTCATTTATGTTATTAGGGAAAATTATGACGGTTTATTTAGGTCCAAAAGGT CATGAATTTGTTTTTAATGCTAAATTATCTGATGTTTCTGCTGAAGATGCTTATAAACAT TTAACTACTCCAGTTTTCGGTAAAGGGGTTATTTATGATTGTCCAAATTCCAGATTAATG GAACAAAAAAAATTTGCTAAATTTGCTTTGACTACTGATTCATTTAAAAGATATGTTCCT AAGATTAGAGAAGAAATTTTGAATTATTTTGTTACTGATGAAAGTTTCAAATTGAAAGAA AAAACTCATGGGGTTGCCAATGTTATGAAAACTCAACCAGAAATTACTATTTTCACTGCT TCAAGATCTTTATTTGGTGATGAAATGAGAAGAATTTTTGACCGTTCATTTGCTCAACTA TATTCTGATTTAGATAAAGGTTTTACCCCTATTAATTTTGTTTTCCCTAATTTACCTTTA CCTCATTATTGGAGACGTGATGCTGCTCAAAAGAAAATCTCTGCTACTTATATGAAAGAA ATTAAACTGAGAAGAGAACGTGGTGATATTGATCCAAATCGTGATTTAATTGATTCCTTA TTGATTCATTCAACTTATAAAGATGGTGTGAAAATGACTGATCAAGAAATTGCTAATCTT TTAATTGGTATTCTTATGGGTGGTCAACATACTTCTGCTTCTACTTCTGCTTGGTTCTTG TTACATTTAGGTGAAAAACCTCATTTACAAGATGTTATTTATCAAGAAGTTGTTGAATTG TTGAAAGAAAAAGGTGGTGATTTGAATGATTTGACTTATGAAGATTTACAAAAATTACCA TCAGTCAATAACACTATTAAGGAAACTCTTAGAATGCATATGCCATTACATTCTATTTTT AGAAAAGTTACTAACCCATTAAGAATCCCTGAAACCAATTATATTGTTCCAAAAGGTCAT TATGTTTTAGTTTCTCCAGGTTATGCTCATACTAGTGAAAGATATTTTGATAACCCTGAA GATTTTGATCCAACTAGATGGGATACTGCTGCTGCCAAAGCTAATTCTGTTTCATTTAAC TCTTCTGATGAAGTTGATTATGGGTTTGGGAAAGTTTCTAAAGGGGTTTCTTCACCTTAT TTACCATTTGGTGGTGGTAGACATAGATGTATTGGGGAACAATTTGCTTATGTTCAATTG GGAACCATTTTAACTACTTTTGTTTATAACTTAAGATGGACTATTGATGGTTATAAAGTG CCTGACCCTGATTATAGTTCAATGGTGGTTTTACCTACTGAACCAGCAGAAATCATTTGG GAAAAAAGAGAAACTTGTATGTTTTAA
pfams:PF00067p450
go-classifiers:componentendoplasmic reticulumcomponentintegral component of membranecomponentmembranecomponentplasma membranefunctiondrug bindingfunctionheme bindingfunctioniron ion bindingfunctionsterol 14-demethylase activityprocesscell growth mode switching, budding to filamentousprocesscellular response to drugprocessdemethylationprocessergosterol biosynthetic processprocessmembrane raft polarizationprocessoxidation-reduction process
id:BE0004668
name:Lanosterol synthase
organism:Yeast
action:inhibitor
Gebre-Hiwot A, Frommel D: The in-vitro anti-leishmanial activity of inhibitors of ergosterol biosynthesis. J Antimicrob Chemother. 1993 Dec;32(6):837-42.
known-action:yes
name:Lanosterol synthase
general-function:Lanosterol synthase activity
specific-function:Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
gene-name:ERG7
locus:
cellular-location:
transmembrane-regions:
signal-regions:
theoretical-pi:
molecular-weight:83713.975
chromosome-location:
organism:Yeast
external-identifiers:UniProtKBQ04782UniProt AccessionERG7_CANAL
synonyms:2,3-epoxysqualene--lanosterol cyclase5.4.99.7OSCOxidosqualene--lanosterol cyclase
amino-acid-sequence:>lcl|BSEQ0020786|Lanosterol synthase MYYSEEIGLPKTDISRWRLRSDALGRETWHYLSQSECESEPQSTFVQWLLESPDFPSPPS SDIHTSGEAARKGADFLKLLQLDNGIFPCQYKGPMFMTIGYVTANYYSKTEIPEPYRVEM IRYIVNTAHPVDGGWGLHSVDKSTCFGTTMNYVCLRLLGMEKDHPVLVKARKTLHRLGGA IKNPHWGKAWLSILNLYEWEGVNPAPPELWRLPYWLPIHPAKWWVHTRAIYLPLGYTSAN RVQCELDPLLKEIRNEIYVPSQLPYESIKFGNQRNNVCGVDLYYPHTKILDFANSILSKW EAVRPKWLLNWVNKKVYDLIVKEYQNTEYLCIAPVSFAFNMVVTCHYEGSESENFKKLQN RMNDVLFHGPQGMTVMGTNGVQVWDAAFMVQYFFMTGLVDDPKYHDMIRKSYLFLVRSQF TENCVDGSFRDRRKGAWPFSTKEQGYTVSDCTAEAMKAIIMVRNHASFADIRDEIKDENL FDAVEVLLQIQNVGEWEYGSFSTYEGIKAPLLLEKLNPAEVFNNIMVEYPYVECTDSSVL GLTYFAKYYPDYKPELIQKTISSAIQYILDSQDNIDGSWYGCWGICYTYASMFALEALHT VGLDYESSSAVKKGCDFLISKQLPDGGWSESMKGCETHSYVNGENSLVVQSAWALIGLIL GNYPDEEPIKRGIQFLMKRQLPTGEWKYEDIEGVFNHSCAIEYPSYRFLFPIKALGLYKN KYGDKVLV
gene-sequence:>lcl|BSEQ0020787|Lanosterol synthase (ERG7) ATGTATTATTCAGAGGAAATTGGTCTTCCCAAAACTGATATTTCAAGATGGAGGTTACGA AGTGACGCTCTTGGTAGGGAAACATGGCATTATCTATCACAATCTGAATGTGAAAGTGAA CCACAATCAACATTTGTCCAATGGCTTTTAGAGTCGCCAGATTTTCCATCTCCGCCATCG TCAGATATTCATACTTCAGGCGAGGCAGCAAGAAAGGGAGCTGATTTTTTGAAACTATTG CAATTGGATAATGGTATCTTCCCCTGCCAGTACAAAGGTCCAATGTTTATGACAATTGGC TATGTAACTGCTAATTATTATAGCAAGACTGAGATACCTGAGCCGTATAGAGTTGAGATG ATACGTTATATTGTCAACACTGCACACCCAGTCGATGGTGGTTGGGGACTTCATTCTGTT GATAAATCTACTTGTTTTGGGACAACCATGAATTATGTATGTCTCCGGTTATTAGGAATG GAAAAGGATCATCCAGTTTTGGTTAAGGCGAGAAAAACATTACATCGTTTGGGTGGTGCC ATTAAGAATCCACATTGGGGTAAGGCTTGGCTATCTATTTTGAATTTATATGAATGGGAG GGTGTGAACCCAGCTCCACCAGAACTTTGGAGATTACCGTACTGGTTACCAATTCATCCA GCGAAATGGTGGGTACATACTAGGGCTATCTATTTGCCATTGGGATATACGTCTGCAAAC AGAGTTCAATGTGAGCTTGATCCACTTTTAAAAGAGATCAGAAATGAAATTTACGTTCCA AGTCAATTACCTTATGAGTCAATCAAATTTGGTAACCAGAGAAATAATGTTTGTGGTGTC GATTTATATTACCCACATACAAAGATTCTTGATTTTGCAAATTCTATATTGAGTAAATGG GAAGCTGTTAGACCTAAGTGGTTATTGAATTGGGTTAACAAGAAAGTTTATGATTTAATT GTAAAGGAGTATCAGAATACAGAGTACTTGTGTATTGCTCCTGTGAGTTTTGCCTTCAAT ATGGTTGTGACGTGTCATTATGAGGGCTCTGAATCAGAAAACTTTAAGAAACTCCAAAAC AGAATGAACGATGTTTTGTTTCATGGACCTCAGGGAATGACTGTTATGGGGACAAATGGT GTACAAGTTTGGGATGCCGCCTTTATGGTACAGTACTTTTTCATGACAGGCTTAGTTGAT GACCCAAAATATCACGATATGATCAGAAAGAGTTATTTATTTTTAGTGAGATCTCAATTT ACAGAAAATTGTGTCGATGGAAGTTTCAGAGATAGACGTAAAGGTGCTTGGCCATTTAGT ACTAAGGAACAAGGATATACTGTTAGTGACTGTACTGCAGAAGCAATGAAGGCTATTATT ATGGTTAGGAATCATGCAAGTTTTGCTGACATCAGGGACGAAATAAAAGATGAAAACTTG TTTGATGCTGTTGAAGTTTTGTTGCAAATTCAAAATGTGGGAGAATGGGAATATGGCTCA TTCTCGACTTATGAAGGTATAAAAGCCCCTTTGTTGCTAGAAAAATTGAATCCTGCCGAG GTTTTTAATAATATTATGGTGGAGTATCCATACGTGGAATGTACAGACTCTTCCGTTTTA GGGCTTACTTACTTTGCCAAATATTACCCTGACTACAAGCCCGAATTGATTCAGAAAACT ATTTCCTCTGCCATTCAATATATTCTTGATTCACAAGATAACATTGATGGCTCTTGGTAT GGTTGTTGGGGAATTTGTTATACTTATGCGTCGATGTTTGCATTAGAAGCTTTGCATACA GTTGGTCTTGATTATGAATCCTCATCAGCTGTGAAAAAAGGATGTGATTTTCTTATTTCA AAACAACTTCCAGACGGTGGATGGTCAGAATCAATGAAAGGTTGTGAAACACACTCTTAT GTCAATGGTGAAAACTCTCTTGTTGTTCAATCGGCTTGGGCTTTGATAGGGTTGATATTG GGAAATTATCCTGATGAAGAGCCAATCAAAAGAGGAATTCAATTTTTGATGAAACGACAA TTACCGACTGGTGAGTGGAAGTATGAAGATATTGAAGGTGTATTTAATCACAGTTGTGCA ATAGAATATCCTTCATATAGGTTTTTATTTCCAATTAAGGCATTAGGTTTATATAAAAAC AAGTATGGTGATAAAGTGTTAGTTTAA
pfams:PF13243SQHop_cyclase_CPF13249SQHop_cyclase_N
go-classifiers:functionlanosterol synthase activityprocessergosterol biosynthetic process
id:BE0000956
name:Nuclear receptor subfamily 1 group I member 2
organism:Humans
action:partial agonist
Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P: Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36(2):339-48. Epub 2007 Nov 12.
known-action:unknown
name:Nuclear receptor subfamily 1 group I member 2
general-function:Zinc ion binding
specific-function:Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
gene-name:NR1I2
locus:3q12-q13.3
cellular-location:Nucleus
transmembrane-regions:
signal-regions:
theoretical-pi:8.44
molecular-weight:49761.245
chromosome-location:3
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:7968GenAtlasNR1I2GenBank Gene DatabaseAF061056GenBank Protein Database3511138IUPHAR606Guide to Pharmacology606UniProtKBO75469UniProt AccessionNR1I2_HUMAN
synonyms:Orphan nuclear receptor PAR1Orphan nuclear receptor PXRPregnane X receptorPXRSteroid and xenobiotic receptorSXR
amino-acid-sequence:>lcl|BSEQ0001903|Nuclear receptor subfamily 1 group I member 2 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF ATPLMQELFGITGS
gene-sequence:>lcl|BSEQ0010672|Nuclear receptor subfamily 1 group I member 2 (NR1I2) CTGGAGGTGAGACCCAAAGAAAGCTGGAACCATGCTGACTTTGTACACTGTGAGGACACA GAGTCTGTTCCTGGAAAGCCCAGTGTCAACGCAGATGAGGAAGTCGGAGGTCCCCAAATC TGCCGTGTATGTGGGGACAAGGCCACTGGCTATCACTTCAATGTCATGACATGTGAAGGA TGCAAGGGCTTTTTCAGGAGGGCCATGAAACGCAACGCCCGGCTGAGGTGCCCCTTCCGG AAGGGCGCCTGCGAGATCACCCGGAAGACCCGGCGACAGTGCCAGGCCTGCCGCCTGCGC AAGTGCCTGGAGAGCGGCATGAAGAAGGAGATGATCATGTCCGACGAGGCCGTGGAGGAG AGGCGGGCCTTGATCAAGCGGAAGAAAAGTGAACGGACAGGGACTCAGCCACTGGGAGTG CAGGGGCTGACAGAGGAGCAGCGGATGATGATCAGGGAGCTGATGGACGCTCAGATGAAA ACCTTTGACACTACCTTCTCCCATTTCAAGAATTTCCGGCTGCCAGGGGTGCTTAGCAGT GGCTGCGAGTTGCCAGAGTCTCTGCAGGCCCCATCGAGGGAAGAAGCTGCCAAGTGGAGC CAGGTCCGGAAAGATCTGTGCTCTTTGAAGGTCTCTCTGCAGCTGCGGGGGGAGGATGGC AGTGTCTGGAACTACAAACCCCCAGCCGACAGTGGCGGGAAAGAGATCTTCTCCCTGCTG CCCCACATGGCTGACATGTCAACCTACATGTTCAAAGGCATCATCAGCTTTGCCAAAGTC ATCTCCTACTTCAGGGACTTGCCCATCGAGGACCAGATCTCCCTGCTGAAGGGGGCCGCT TTCGAGCTGTGTCAACTGAGATTCAACACAGTGTTCAACGCGGAGACTGGAACCTGGGAG TGTGGCCGGCTGTCCTACTGCTTGGAAGACACTGCAGGTGGCTTCCAGCAACTTCTACTG GAGCCCATGCTGAAATTCCACTACATGCTGAAGAAGCTGCAGCTGCATGAGGAGGAGTAT GTGCTGATGCAGGCCATCTCCCTCTTCTCCCCAGACCGCCCAGGTGTGCTGCAGCACCGC GTGGTGGACCAGCTGCAGGAGCAATTCGCCATTACTCTGAAGTCCTACATTGAATGCAAT CGGCCCCAGCCTGCTCATAGGTTCTTGTTCCTGAAGATCATGGCTATGCTCACCGAGCTC CGCAGCATCAATGCTCAGCACACCCAGCGGCTGCTGCGCATCCAGGACATACACCCCTTT GCTACGCCCCTCATGCAGGAGTTGTTCGGCATCACAGGTAGCTGA
pfams:PF00104Hormone_recepPF00105zf-C4
go-classifiers:componentnucleoplasmfunctiondrug bindingfunctionRNA polymerase II regulatory region sequence-specific DNA bindingfunctionRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingfunctionsteroid hormone receptor activityfunctiontranscription coactivator activityfunctiontranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingfunctionzinc ion bindingprocessdrug exportprocessexogenous drug catabolic processprocessgene expressionprocessintracellular receptor signaling pathwayprocessnegative regulation of transcription, DNA-templatedprocesspositive regulation of transcription from RNA polymerase II promoterprocesspositive regulation of transcription, DNA-templatedprocesssignal transductionprocesssteroid metabolic processprocesstranscription initiation from RNA polymerase II promoterprocessxenobiotic metabolic processprocessxenobiotic transport

酶

BE0002638Cytochrome P450 3A4HumansinducerA1777017998298Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P: Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36(2):339-48. Epub 2007 Nov 12.unknownCytochrome P450 3A4Vitamin d3 25-hydroxylase activityCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).CYP3A47q21.1Endoplasmic reticulum membrane2-228.2557342.677HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2637GenAtlasCYP3A4GenBank Gene DatabaseM18907Guide to Pharmacology1337UniProtKBP08684UniProt AccessionCP3A4_HUMAN1,8-cineole 2-exo-monooxygenase1.14.13.-Albendazole monooxygenaseAlbendazole sulfoxidaseCholesterol 25-hydroxylaseCYP3A3CYPIIIA3CYPIIIA4Cytochrome P450 3A3Cytochrome P450 HLpCytochrome P450 NF-25Cytochrome P450-PCN1Nifedipine oxidaseQuinine 3-monooxygenaseTaurochenodeoxycholate 6-alpha-hydroxylase>lcl|BSEQ0021936|Cytochrome P450 3A4 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG GLLQPEKPVVLKVESRDGTVSGA>lcl|BSEQ0021937|Cytochrome P450 3A4 (CYP3A4) ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG CTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG CCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTT GACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCT GTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT GTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATA GCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGA AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGC ATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTT CTCTCAATAATCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTGTTT CCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGCCTC GAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAATTCA AAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATTATC TTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTG GCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAAT AAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAAT GAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTT GAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTT CACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAG AAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAAC TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGAGGA CTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTAAGT GGAGCCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintegral component of membranecomponentintracellular membrane-bounded organellefunctionalbendazole monooxygenase activityfunctionaromatase activityfunctioncaffeine oxidase activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxygen bindingfunctionquinine 3-monooxygenase activityfunctionsteroid bindingfunctionsteroid hydroxylase activityfunctiontaurochenodeoxycholate 6alpha-hydroxylase activityfunctiontestosterone 6-beta-hydroxylase activityfunctionvitamin D 24-hydroxylase activityfunctionvitamin D3 25-hydroxylase activityprocessalkaloid catabolic processprocessandrogen metabolic processprocesscalcitriol biosynthetic process from calciolprocessdrug catabolic processprocessdrug metabolic processprocessexogenous drug catabolic processprocessheterocycle metabolic processprocesslipid metabolic processprocessmonoterpenoid metabolic processprocessoxidation-reduction processprocessoxidative demethylationprocesssmall molecule metabolic processprocesssteroid catabolic processprocesssteroid metabolic processprocessvitamin D metabolic processprocessxenobiotic metabolic processunknownBE0003536Cytochrome P450 2C19HumanssubstrateA1777121177487Mahajan MK, Uttamsingh V, Daniels JS, Gan LS, LeDuc BW, Williams DA: In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite. Drug Metab Dispos. 2011 Apr;39(4):693-702. doi: 10.1124/dmd.110.036004. Epub 2010 Dec 21.unknownCytochrome P450 2C19Steroid hydroxylase activityResponsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.CYP2C1910q24.1-q24.3Endoplasmic reticulum membrane7.4255930.54510HumansHUGO Gene Nomenclature Committee (HGNC)HGNC:2621GenBank Gene DatabaseM61854GenBank Protein Database181344Guide to Pharmacology1328UniProtKBP33261UniProt AccessionCP2CJ_HUMAN(R)-limonene 6-monooxygenase(S)-limonene 6-monooxygenase(S)-limonene 7-monooxygenase1.14.13.-CYPIIC17CYPIIC19Cytochrome P450-11ACytochrome P450-254CMephenytoin 4-hydroxylase>lcl|BSEQ0020694|Cytochrome P450 2C19 MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP PFYQLCFIPV>lcl|BSEQ0020695|Cytochrome P450 2C19 (CYP2C19) ATGGATCCTTTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCAATCTGG AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA AATATCCTACAGATAGATATTAAGGATGTCAGCAAATCCTTAACCAATCTCTCAAAAATC TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGGAACGCATGGTGGTGCTGCATGGATAT GAAGTGGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCCATTTC CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATCGTTTTCAGCAATGGAAAGAGATGG AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG GCTTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC ATTATTTTCCAGAAACGTTTCGATTATAAAGATCAGCAATTTCTTAACTTGATGGAAAAA TTGAATGAAAACATCAGGATTGTAAGCACCCCCTGGATCCAGATATGCAATAATTTTCCC ACTATCATTGATTATTTCCCGGGAACCCATAACAAATTACTTAAAAACCTTGCTTTTATG GAAAGTGATATTTTGGAGAAAGTAAAAGAACACCAAGAATCGATGGACATCAACAACCCT CGGGACTTTATTGATTGCTTCCTGATCAAAATGGAGAAGGAAAAGCAAAACCAACAGTCT GAATTCACTATTGAAAACTTGGTAATCACTGCAGCTGACTTACTTGGAGCTGGGACAGAG ACAACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA GCTAAAGTCCAGGAAGAGATTGAACGTGTCATTGGCAGAAACCGGAGCCCCTGCATGCAG GACAGGGGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATCGAC CTCATCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACGTTAAATTCAGAAACTACCTC ATTCCCAAGGGCACAACCATATTAACTTCCCTCACTTCTGTGCTACATGACAACAAAGAA TTTCCCAACCCAGAGATGTTTGACCCTCGTCACTTTCTGGATGAAGGTGGAAATTTTAAG AAAAGTAACTACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAGGGCCTG GCCCGCATGGAGCTGTTTTTATTCCTGACCTTCATTTTACAGAACTTTAACCTGAAATCT CTGATTGACCCAAAGGACCTTGACACAACTCCTGTTGTCAATGGATTTGCTTCTGTCCCG CCCTTCTATCAGCTGTGCTTCATTCCTGTCTGAPF00067p450componentcytoplasmcomponentendoplasmic reticulum membranecomponentintracellular membrane-bounded organellefunction(R)-limonene 6-monooxygenase activityfunction(S)-limonene 6-monooxygenase activityfunction(S)-limonene 7-monooxygenase activityfunctionarachidonic acid epoxygenase activityfunctionenzyme bindingfunctionheme bindingfunctioniron ion bindingfunctionmonooxygenase activityfunctionoxidoreductase activityfunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenfunctionoxygen bindingfunctionsteroid hydroxylase activityprocessarachidonic acid metabolic processprocessdrug metabolic processprocessepoxygenase P450 pathwayprocessexogenous drug catabolic processprocessheterocycle metabolic processprocessmonoterpenoid metabolic processprocessomega-hydroxylase P450 pathwayprocessoxidation-reduction processprocesssmall molecule metabolic processprocesssteroid metabolic processprocessxenobiotic metabolic process

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