ID
DB00241|APRD00266||
名称
Butalbital
描述
Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from mild sedation to general anesthesia.[A177754] Butalbital has a low degree of selectivity and a narrow therapeutic index.[A177754] Typically indicated to manage tension (or muscle contraction) headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid, acetaminophen, aspirin, and caffeine. There have not been clinical trials that evaluate the clinical efficacy of butalbital in migraines [A177754] thus it is not indicated for such condition. As with other barbiturates, butalbital carries a risk of abuse or misuse potential, intoxication, hangover, tolerance, dependence, and overdosage possibly leading to death.[L10370] Butalbital‐containing analgesics can also produce a drug‐induced headache in addition to tolerance and dependence. Due to these risks, the use of butalbital-containing combination products is typically limited for use only in cases where other medications are deemed ineffective and such usage is advised to be carefully monitored.[A177754]
cas号
77-26-9
唯一标识码
KHS0AZ4JVK
状态
solid
一般参考文献
Silberstein SD, McCrory DC: Butalbital in the treatment of headache: history, pharmacology, and efficacy. Headache. 2001 Nov-Dec;41(10):953-67.
Wenzel RG, Sarvis CA: Do butalbital-containing products have a role in the management of migraine? Pharmacotherapy. 2002 Aug;22(8):1029-35.
Bryczkowski C, Geib AJ: Combined butalbital/acetaminophen/caffeine overdose: case files of the Robert Wood Johnson Medical School Toxicology Service. J Med Toxicol. 2012 Dec;8(4):424-31. doi: 10.1007/s13181-012-0261-z.
Puthenkalam R, Hieckel M, Simeone X, Suwattanasophon C, Feldbauer RV, Ecker GF, Ernst M: Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What? Front Mol Neurosci. 2016 Jun 16;9:44. doi: 10.3389/fnmol.2016.00044. eCollection 2016.
Poyant JO, Albright R, Clain J, Pandompatam G, Barreto EF: Extracorporeal elimination of butalbital in acute aspirin-butalbital-caffeine-codeine (Fiorinal with Codeine) poisoning. Clin Toxicol (Phila). 2018 Jun;56(6):439-441. doi: 10.1080/15563650.2017.1400554. Epub 2017 Nov 10.
Dain JG, Bhuta SI, Coombs RA, Talbot KC, Dugger HA: Metabolism of butalbital, 5-allyl-5-isobutylbarbituric acid, in the dog. Drug Metab Dispos. 1980 Jul-Aug;8(4):247-52.
Drost ML, Walter L: Blood and plasma concentrations of butalbital following single oral doses in man. J Anal Toxicol. 1988 Nov-Dec;12(6):322-4.
23. (2012). In Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. (pp. 474-476). Hoboken, N.J: John Wiley & Sons.
T598978-0-471-72760-623. (2012). In Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. (pp. 474-476). Hoboken, N.J: John Wiley & Sons.
Butalbital - National Library of Medicine HSDB Database
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+7853
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Capsules - FDA Label
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020232s041lbl.pdf
N-FIORINAL®-C 1/4, 1/2 (acetylsalicylic acid-caffeine-codeine-butalbital) Product Information - Novartis Canada
//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/004/561/original/fiorinal-c_scrip_e.pdf?1556644474
F4561N-FIORINAL®-C 1/4, 1/2 (acetylsalicylic acid-caffeine-codeine-butalbital) Product Information - Novartis Canada//s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/004/561/original/fiorinal-c_scrip_e.pdf?1556644474
approved,illicit,
指示
Indicated for the management of the symptom complex of tension (or muscle contraction) headache, when other non-opioid analgesics and alternative treatments are inadequate, in various combinations with acetaminophen, aspirin, caffeine, and codeine .[L10370]
药效学
Butalbital is a short to intermediate-acting barbiturate that reversibly depresses the activity of excitable tissues, including the central nervous system in a nonselective manner.[A177754] Barbiturates exhibit muscle-relaxing and anti-anxiety properties [A177763] and they are capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma.[F4561] The sedative dose of butalbital in nontolerant individuals is 5-100 mg and the hypnotic dose is 100-200 mg.[T598] Pain perception and reaction are relatively unimpaired until the moment of unconsciousness.[A177754] In some cases, an unwanted paradoxical response of excitement may be observed instead of sedation with barbiturate treatment, which may be due to their depressant effects on inhibitory centers of the CNS.[A177754] At sufficiently high therapeutic doses, barbiturates induce anesthesia; however, barbiturates are reported to lose their effectiveness for sleep induction and sleep maintenance after 2 weeks.[F4561] Barbiturates are habit-forming; they can produce tolerance and both dependence and addiction, which is partly explained by decreased drug concentration at the site of action due to enhanced drug metabolism by induced enzymes, or to cellular adaptive changes. In addition, butalbital may lead to analgesic overuse headache.[A177754] While butalbital is expected to mediate similar actions as other members of the barbiturate drug class, the effects of butalbital in isolation are not well understood.[A177763] It is suggested that butalbital is added in combination products to antagonize the unwanted central stimulating effect of stimulatory ingredients such as caffeine.[A177763] Butalbital may decrease blood pressure and heart rate when administered at sedative and hypnotic doses.[L10370]
作用机制
Butalbital is a CNS depressant that suppresses neuronal excitability, impulse conduction, and the release of neurotransmitters, similar to actions of other barbiturates.[T598] Barbiturates primarily mediate suppressive actions on polysynaptic neuronal responses by diminishing facilitation while enhancing inhibition.[A177754] Inhibition occurs at GABAergic synapses that express GABA-A receptors, which are transmembrane chloride ion channels that bind an inhibitory neurotransmitter GABA, barbiturates, benzodiazepines, neurosteroids, and ethanol.[A177754] Upon activation, GABA-A receptors allow Cl- influx and K+ efflux into the postjunctional terminal, resulting in inhibition of the postsynaptic neuron. It is suggested that barbiturates, including butalbital, enhances GABA binding to the GABA-A receptors [F4561] by binding to the α+/β− interface in the intracellular domain (ICD) as an allosteric modulator.[A177829] Additionally, barbiturates promote benzodiazepine binding to the receptor.[A177754] Barbiturates potentiate GABA-induced increases in chloride conductance and depress voltage-activated calcium currents while prolonging the duration of GABA-induced chloride channel opening.[A177754] Butalbital may also inhibit the excitatory effects mediated by AMPA receptors by reducing glutamate-induced depolarizations of the receptor. It is also proposed that barbiturates and opioids may potentiate the analgesic effects of each other when co-administered, although there are inconsistencies across preclinical data.[A177754]
毒性
Reported oral TDLO (woman) is 400 mg/kg and subcutaneous LD50 in rat is 160 mg/kg.[MSDS] The lowest acute dose of butalbital alone associated with death in adults is 2.0 g.[A177754] Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock. Due to the CNS depressant effects, an overdose of barbiturates may lead to death.[L10370] Barbiturates are also associated with withdrawal reactions, which may lead to death if severe.[A177754]
代谢
Butalbital is expected to undergo nearly complete hepatic metabolism.[A177754] It primarily undergoes C5 oxidation to form 5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid, which is the major metabolite. Butalbital may also undergo omega-hydroxylation to form 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid.[A177835, L10370, T598]
吸收
Butalbital gets readily and rapidly absorbed from the gastrointestinal tract.[F4561] The time to reach the peak plasma concentrations is reported to be approximately 2 hours.[A177754] Typical blood concentrations of butalbital peaked at 2.1 mg/L and declined to 1.5 mg/L at 24 hr.[A177838] Plasma concentrations of 10 to 20 μg/mL have been associated with toxicity; coma and fatalities have occurred with concentrations of 25 to 30 μg/mL.[A177754]
半衰期
The plasma half-life is about 35 hours. In a study of 5 healthy volunteers receiving 100 mg butalbital in combination with aspirin and caffeine, the mean plasma elimination half-life of butalbital was 61 hours, with the range of 35 to 88 hours.[A177838, T598]
分类
description:This compound belongs to the class of organic compounds known as barbituric acid derivatives. These are compounds containing a perhydropyrimidine ring substituted at C-2, -4 and -6 by oxo groups.
direct-parent:Barbituric acid derivatives
kingdom:Organic compounds
superclass:Organoheterocyclic compounds
class:Diazines
subclass:Pyrimidines and pyrimidine derivatives
alternative-parent:Azacyclic compounds
alternative-parent:Carbonyl compounds
alternative-parent:Diazinanes
alternative-parent:Dicarboximides
alternative-parent:Hydrocarbon derivatives
alternative-parent:N-acyl ureas
alternative-parent:Organic oxides
alternative-parent:Organonitrogen compounds
alternative-parent:Organopnictogen compounds
substituent:1,3-diazinane
substituent:Aliphatic heteromonocyclic compound
substituent:Azacycle
substituent:Barbiturate
substituent:Carbonic acid derivative
substituent:Carbonyl group
substituent:Carboxylic acid derivative
substituent:Dicarboximide
substituent:Hydrocarbon derivative
substituent:N-acyl urea
substituent:Organic nitrogen compound
substituent:Organic oxide
substituent:Organic oxygen compound
substituent:Organonitrogen compound
substituent:Organooxygen compound
substituent:Organopnictogen compound
substituent:Urea
substituent:Ureide
消除途径
Butalbital predominantly undergoes renal elimination with 59 to 88% of the total dose administered being excreted from the kidneys as unchanged parent drug or metabolites.[L6121,L10370] Urinary excretion products included parent drug (about 3.6% of the dose), 5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8%), products with the barbituric acid ring hydrolyzed with excretion of urea (about 14% of the dose), as well as unidentified materials.[L10370] Of the material excreted in the urine, 32% is conjugated.[L10370] Elimination is not complete within 24 hours, and the drug accumulates with frequent administration.[A177754]
种类
Anticholinergic Agents
D018680
Anticonvulsants
D000927
Barbiturates
D001463
Central Nervous System Depressants
D002492
Cytochrome P-450 CYP3A Inducers
D065701
Cytochrome P-450 CYP3A4 Inducers
D065701
Cytochrome P-450 CYP3A4 Inducers (strength unknown)

Cytochrome P-450 Enzyme Inducers
D065693
Hypnotics and Sedatives
D006993
Methemoglobinemia Associated Agents

Nervous System
D009420
Nicotinic Antagonists
D018733
Psycholeptics

Pyrimidines
D011743
Pyrimidinones
D011744
盐类
DBSALT002235Butalbital sodiumBBH31P2ABJ23554-70-3LIZXGILRVOONMO-UHFFFAOYSA-M246.242246.09803663
蛋白质结合
The _in vitro_ plasma protein binding of butalbital is 45% over the concentration range of 0.5-20 mcg/mL. This falls within the range of plasma protein binding (20%-45%) reported with other barbiturates such as phenobarbital, pentobarbital, and secobarbital sodium.[L10370]
清除
There is limited data on the clearance of butalbital.
同义词
language:english; code:; name;5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
language:english; code:; name;5-allyl-5-(2-methylpropyl)barbituric acid
language:english; code:; name;5-allyl-5-(2'-methyl-n-propyl) barbituric acid
language:english; code:; name;5-allyl-5-isobutyl-2,4,6(1H,3H,5H)-pyrimidinetrione
language:english; code:; name;5-Allyl-5-isobutyl-pyrimidine-2,4,6-trione
language:english; code:; name;5-allyl-5-isobutylbarbituric acid
language:english; code:; name;5-isobutyl-5-allylbarbituric acid
language:english; code:; name;Allylbarbital
language:english; code:; name;Allylbarbitone
language:english; code:; name;Allylbarbituric acid
language:english; code:; name;Butalbarbital
language:english; code:inn/usan; name;Butalbital
language:latin; code:inn; name;Butalbitalum
language:english; code:; name;iso-butylallylbarbituric acid
language:english; code:; name;Itobarbital
language:english; code:; name;Tetrallobarbital
国际品牌
SandoptalSandoz Pharmaceuticals Corporations
配送量
The volume of distribution of butalbital is reported to be approximately 0.8 L/kg.[T598] Butalbital is expected to distribute to most of the tissues in the body [F4561], including the mamillary glands and placenta.[F4561] The plasma-to-blood concentration ratio was almost unity indicating that there is no preferential distribution of butalbital into either plasma or blood cells.[L10370]
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混合物
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
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name:Orbivan
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine Plus
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Acetaminophen, Butalbital and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Fioricet with Codeine
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Fioricet
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Fiorinal with Codeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Fiorinal
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Orbivan
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Esgic-Plus
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Esgic-Plus
ingredients:Acetaminophen + Butalbital + Caffeine
name:Bupap
ingredients:Acetaminophen + Butalbital
name:Esgic-Plus
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Esgic-Plus
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Phrenilin Forte
ingredients:Acetaminophen + Butalbital
name:Orbivan CF
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
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ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Dolgic Plus
ingredients:Acetaminophen + Butalbital + Caffeine
name:Alagesic LQ
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Phrenilin
ingredients:Acetaminophen + Butalbital
name:Phrenilin Forte
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetominophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetominophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Esgic
ingredients:Acetaminophen + Butalbital + Caffeine
name:Fioricet
ingredients:Acetaminophen + Butalbital + Caffeine
name:Fioricet with Codeine
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Tencon
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
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ingredients:Acetaminophen + Butalbital + Caffeine
name:Esgic
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen 50 mg/325 mg
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name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital Compound
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
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name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, aspirin, and caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Capacet
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Marten-Tab
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Fiorinal
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Aspirin, Caffeine, and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Aspirin, Caffeine, and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital And Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Fiorinal
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Fiorinal with Codeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Aspirin, Caffeine, and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital And Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Allzital
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Esgic
ingredients:Acetaminophen + Butalbital + Caffeine
name:Zebutal
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Ascomp with Codeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Vanatol LQ
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Esgic
ingredients:Acetaminophen + Butalbital + Caffeine
name:Vanatol S
ingredients:Acetaminophen + Butalbital + Caffeine
name:Vtol LQ
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, aspirin, and caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Allzital
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butapap
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, Caffeine and Codeine Phosphate
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Ascomp with Codeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Fioricet with Codeine
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Tencon
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbita,Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Bupap
ingredients:Acetaminophen + Butalbital
name:Fioricet
ingredients:Acetaminophen + Butalbital + Caffeine
name:Margesic
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, aspirin, and caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine with Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetominophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin, and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Phrenilin Forte
ingredients:Acetaminophen + Butalbital + Caffeine
name:Fioricet
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, aspirin, and caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital And Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Fioricet
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Aspirin and Caffeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Fiorinal with Codeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
ingredients:Acetaminophen + Butalbital + Caffeine + Codeine
name:Butalbital and Acetaminophen
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Ascomp with Codeine
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Allzital
ingredients:Acetaminophen + Butalbital
name:Butalbital, Acetaminophen and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Butalbital, Acetaminophen, and Caffeine
ingredients:Acetaminophen + Butalbital + Caffeine
name:Pronal - C1/2 Capsules
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Fiorinal-C 1/4
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Fiorinal-C 1/2
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Trianal Tablet
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Trianal Capsules
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:PMS-pharnal-C 1/4 Capsules
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:PMS-pharnal-C1/2 Capsules
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:PMS-pharnal Capsules
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:PMS-pharnal Tablets
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Teva-tecnal
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Teva-tecnal C 1/2
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Trianal C½
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Trianal C¼
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Pronal Tablets
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Teva-tecnal C 1/4
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Teva-tecnal
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Fiorinal Tab
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Pronal Capsules
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
name:Pronal C1/4 Capsules
ingredients:Acetylsalicylic acid + Butalbital + Caffeine + Codeine
name:Fiorinal
ingredients:Acetylsalicylic acid + Butalbital + Caffeine
包装者
name:Atley Pharmaceuticals
url:http://www.atley.com
name:Cardinal Health
url:http://www.cardinal.com
name:Chattem Chemicals Inc.
url:http://www.chattem.com
name:D.M. Graham Laboratories Inc.
url:
name:Diversified Healthcare Services Inc.
url:http://www.dhscorp.com
name:ECR Pharmaceuticals
url:http://www.ecrpharma.com
name:Everett Laboratories Inc.
url:http://www.everettlabs.com
name:Innoviant Pharmacy Inc.
url:http://www.innoviantpharmacy.com
name:International Ethical Labs Inc.
url:http://www.intetlab.com
name:Ivax Pharmaceuticals
url:
name:Marnel Pharmaceuticals Inc.
url:
name:MCR American Pharmaceuticals Inc.
url:http://www.mcramerican.com
name:Medisca Inc.
url:http://www.medisca.com
name:Merz Pharmaceuticals LLC
url:http://www.merz.com
name:Mikart Inc.
url:http://www.mikart.com
name:Nucare Pharmaceuticals Inc.
url:http://www.nucarerx.com
name:PD-Rx Pharmaceuticals Inc.
url:http://www.pdrx.com
name:Physicians Total Care Inc.
url:http://www.physicianstotalcare.com
name:Qualitest
url:http://www.worldoftest.com
name:Savage Labs
url:http://www.savagelabs.com
name:Southwood Pharmaceuticals
url:http://www.southwoodhealthcare.com
name:Stat Rx Usa
url:http://statrxusa.exporterus.com
name:Va Cmop Dallas
url:
name:Valeant Ltd.
url:http://www.valeant.com
name:West-Ward Pharmaceuticals
url:http://www.west-ward.com
生产者
价格
Butalbital compound tablet
1.04(单位:USD)
tablet
Butalbital powder
3.83(单位:USD)
g
受影响的生物体
Humans and other mammals
剂量
form:Syrup
route:Oral
strength:
form:Tablet, coated
route:Oral
strength:
form:Tablet
route:Oral
strength:
form:Capsule
route:Oral
strength:
form:Suppository
route:Rectal
strength:150 mg
form:Tablet, coated
route:Oral
strength:50 mg
atc代码
Barbiturates, combinations
HYPNOTICS AND SEDATIVES
PSYCHOLEPTICS
NERVOUS SYSTEM
fda标签
化学品安全技术说明书
//s3-us-west-2.amazonaws.com/drugbank/msds/DB00241.pdf?1556642744
专利
食物相互作用
Avoid alcohol. Profound CNS depression can occur.
药物相互作用
DB01238
The metabolism of Aripiprazole can be increased when combined with Butalbital.
DB14185
The metabolism of Aripiprazole lauroxil can be increased when combined with Butalbital.
DB00921
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
DB00366
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00470
Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00450
Droperidol may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00956
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
DB00557
Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00653
The therapeutic efficacy of Butalbital can be increased when used in combination with Magnesium sulfate.
DB01403
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
DB00765
Butalbital may increase the sedative activities of Metyrosine.
DB01017
Minocycline may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00370
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
DB00486
Nabilone may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB01173
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
DB09117
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
DB00413
Butalbital may increase the sedative activities of Pramipexole.
DB00268
Butalbital may increase the sedative activities of Ropinirole.
DB05271
Butalbital may increase the sedative activities of Rotigotine.
DB06201
The risk or severity of adverse effects can be increased when Rufinamide is combined with Butalbital.
DB09034
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
DB06204
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB01041
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
DB00425
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
DB09527
The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Butalbital.
DB00358
The therapeutic efficacy of Butalbital can be decreased when used in combination with Mefloquine.
DB01083
Orlistat can cause a decrease in the absorption of Butalbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
DB09288
The metabolism of Propacetamol can be increased when combined with Butalbital.
DB00446
The metabolism of Butalbital can be decreased when combined with Chloramphenicol.
DB00254
The serum concentration of Doxycycline can be decreased when it is combined with Butalbital.
DB00949
The serum concentration of Butalbital can be increased when it is combined with Felbamate.
DB00400
The serum concentration of Griseofulvin can be decreased when it is combined with Butalbital.
DB00555
The serum concentration of Lamotrigine can be decreased when it is combined with Butalbital.
DB06148
Mianserin may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00794
The risk or severity of adverse effects can be increased when Primidone is combined with Butalbital.
DB00849
The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Butalbital.
DB00165
The metabolism of Butalbital can be increased when combined with Pyridoxine.
DB00444
The serum concentration of Teniposide can be decreased when it is combined with Butalbital.
DB08867
The serum concentration of Ulipristal can be decreased when it is combined with Butalbital.
DB00582
The serum concentration of Voriconazole can be decreased when it is combined with Butalbital.
DB00750
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Prilocaine.
DB01030
Butalbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
DB00333
The risk or severity of adverse effects can be increased when Methadone is combined with Butalbital.
DB09072
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
DB01181
The metabolism of Ifosfamide can be increased when combined with Butalbital.
DB08883
The metabolism of Perampanel can be increased when combined with Butalbital.
DB00682
The metabolism of Warfarin can be increased when combined with Butalbital.
DB01418
The metabolism of Acenocoumarol can be increased when combined with Butalbital.
DB08496
The metabolism of (R)-warfarin can be increased when combined with Butalbital.
DB08735
The metabolism of R,S-Warfarin alcohol can be increased when combined with Butalbital.
DB08736
The metabolism of S,R-Warfarin alcohol can be increased when combined with Butalbital.
DB14055
The metabolism of (S)-Warfarin can be increased when combined with Butalbital.
DB01284
The risk or severity of liver damage can be increased when Tetracosactide is combined with Butalbital.
DB01223
The therapeutic efficacy of Butalbital can be decreased when used in combination with Aminophylline.
DB00083
The risk or severity of adverse effects can be increased when Butalbital is combined with Botulinum toxin type A.
DB00042
The risk or severity of adverse effects can be increased when Butalbital is combined with Botulinum Toxin Type B.
DB00454
Butalbital may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
DB09099
The risk or severity of adverse effects can be increased when Somatostatin is combined with Butalbital.
DB00898
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
DB00972
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
DB00484
Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00176
The risk or severity of adverse effects can be increased when Butalbital is combined with Fluvoxamine.
DB00215
The risk or severity of adverse effects can be increased when Butalbital is combined with Citalopram.
DB00476
The risk or severity of adverse effects can be increased when Butalbital is combined with Duloxetine.
DB00656
The risk or severity of adverse effects can be increased when Butalbital is combined with Trazodone.
DB00715
The risk or severity of adverse effects can be increased when Butalbital is combined with Paroxetine.
DB01104
The risk or severity of adverse effects can be increased when Butalbital is combined with Sertraline.
DB01105
The risk or severity of adverse effects can be increased when Butalbital is combined with Sibutramine.
DB01149
The risk or severity of adverse effects can be increased when Butalbital is combined with Nefazodone.
DB01175
The risk or severity of adverse effects can be increased when Butalbital is combined with Escitalopram.
DB04832
The risk or severity of adverse effects can be increased when Butalbital is combined with Zimelidine.
DB04884
The risk or severity of adverse effects can be increased when Butalbital is combined with Dapoxetine.
DB06700
The risk or severity of adverse effects can be increased when Butalbital is combined with Desvenlafaxine.
DB06731
The risk or severity of adverse effects can be increased when Butalbital is combined with Seproxetine.
DB08953
The risk or severity of adverse effects can be increased when Butalbital is combined with Indalpine.
DB12693
The risk or severity of adverse effects can be increased when Butalbital is combined with Ritanserin.
DB13233
The risk or severity of adverse effects can be increased when Butalbital is combined with Alaproclate.
DB00704
The risk or severity of adverse effects can be increased when Butalbital is combined with Naltrexone.
DB01459
The risk or severity of adverse effects can be increased when Butalbital is combined with Bezitramide.
DB00295
The risk or severity of adverse effects can be increased when Butalbital is combined with Morphine.
DB00327
The risk or severity of adverse effects can be increased when Butalbital is combined with Hydromorphone.
DB00497
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxycodone.
DB00611
The risk or severity of adverse effects can be increased when Butalbital is combined with Butorphanol.
DB00647
The risk or severity of adverse effects can be increased when Butalbital is combined with Dextropropoxyphene.
DB00652
The risk or severity of adverse effects can be increased when Butalbital is combined with Pentazocine.
DB00708
The risk or severity of adverse effects can be increased when Butalbital is combined with Sufentanil.
DB00844
The risk or severity of adverse effects can be increased when Butalbital is combined with Nalbuphine.
DB00854
The risk or severity of adverse effects can be increased when Butalbital is combined with Levorphanol.
DB00899
The risk or severity of adverse effects can be increased when Butalbital is combined with Remifentanil.
DB01081
The risk or severity of adverse effects can be increased when Butalbital is combined with Diphenoxylate.
DB01192
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxymorphone.
DB01209
The risk or severity of adverse effects can be increased when Butalbital is combined with Dezocine.
DB01433
The risk or severity of adverse effects can be increased when Butalbital is combined with Methadyl acetate.
DB01450
The risk or severity of adverse effects can be increased when Butalbital is combined with Dihydroetorphine.
DB01452
The risk or severity of adverse effects can be increased when Butalbital is combined with Diamorphine.
DB01466
The risk or severity of adverse effects can be increased when Butalbital is combined with Ethylmorphine.
DB01497
The risk or severity of adverse effects can be increased when Butalbital is combined with Etorphine.
DB01529
The risk or severity of adverse effects can be increased when Butalbital is combined with Dextromoramide.
DB01531
The risk or severity of adverse effects can be increased when Butalbital is combined with Desomorphine.
DB01535
The risk or severity of adverse effects can be increased when Butalbital is combined with Carfentanil.
DB01551
The risk or severity of adverse effects can be increased when Butalbital is combined with Dihydrocodeine.
DB01555
The risk or severity of adverse effects can be increased when Butalbital is combined with Alphacetylmethadol.
DB01565
The risk or severity of adverse effects can be increased when Butalbital is combined with Dihydromorphine.
DB06738
The risk or severity of adverse effects can be increased when Butalbital is combined with Ketobemidone.
DB08861
The risk or severity of adverse effects can be increased when Butalbital is combined with DPDPE.
DB09174
The risk or severity of adverse effects can be increased when Butalbital is combined with Lofentanil.
DB11130
The risk or severity of adverse effects can be increased when Butalbital is combined with Opium.
DB11609
The risk or severity of adverse effects can be increased when Butalbital is combined with Normethadone.
DB12492
The risk or severity of adverse effects can be increased when Butalbital is combined with Piritramide.
DB13160
The risk or severity of adverse effects can be increased when Butalbital is combined with Alphaprodine.
DB13454
The risk or severity of adverse effects can be increased when Butalbital is combined with Nicomorphine.
DB13478
The risk or severity of adverse effects can be increased when Butalbital is combined with Meptazinol.
DB13605
The risk or severity of adverse effects can be increased when Butalbital is combined with Phenoperidine.
DB13606
The risk or severity of adverse effects can be increased when Butalbital is combined with Phenazocine.
DB13787
The risk or severity of adverse effects can be increased when Butalbital is combined with Tilidine.
DB15360
The risk or severity of adverse effects can be increased when Butalbital is combined with Carfentanil, C-11.
DB00802
The risk or severity of adverse effects can be increased when Butalbital is combined with Alfentanil.
DB00813
The risk or severity of adverse effects can be increased when Butalbital is combined with Fentanyl.
DB01227
The risk or severity of adverse effects can be increased when Butalbital is combined with Levacetylmethadol.
DB15465
The risk or severity of adverse effects can be increased when Butalbital is combined with Benzhydrocodone.
DB00809
The risk or severity of adverse effects can be increased when Butalbital is combined with Tropicamide.
DB00915
The risk or severity of adverse effects can be increased when Butalbital is combined with Amantadine.
DB00979
The risk or severity of adverse effects can be increased when Butalbital is combined with Cyclopentolate.
DB01090
The risk or severity of adverse effects can be increased when Butalbital is combined with Pentolinium.
DB01116
The risk or severity of adverse effects can be increased when Butalbital is combined with Trimethaphan.
DB01161
The risk or severity of adverse effects can be increased when Butalbital is combined with Chloroprocaine.
DB01288
The risk or severity of adverse effects can be increased when Butalbital is combined with Fenoterol.
DB01496
The risk or severity of adverse effects can be increased when Butalbital is combined with Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione.
DB11181
The risk or severity of adverse effects can be increased when Butalbital is combined with Homatropine.
DB00091
The metabolism of Cyclosporine can be increased when combined with Butalbital.
DB00232
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Methyclothiazide.
DB00310
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Chlorthalidone.
DB00436
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Bendroflumethiazide.
DB00524
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Metolazone.
DB00562
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Benzthiazide.
DB00774
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Hydroflumethiazide.
DB00808
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Indapamide.
DB00880
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Chlorothiazide.
DB00999
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Hydrochlorothiazide.
DB01021
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Trichlormethiazide.
DB01324
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Polythiazide.
DB01325
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Quinethazone.
DB13532
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Cyclopenthiazide.
DB13989
The risk or severity of hypotension and orthostatic hypotension can be increased when Butalbital is combined with Epitizide.
DB00344
The metabolism of Protriptyline can be increased when combined with Butalbital.
DB00543
The metabolism of Amoxapine can be increased when combined with Butalbital.
DB01151
The metabolism of Desipramine can be increased when combined with Butalbital.
DB04836
The metabolism of Amineptine can be increased when combined with Butalbital.
DB08996
The metabolism of Dimetacrine can be increased when combined with Butalbital.
DB09016
The metabolism of Butriptyline can be increased when combined with Butalbital.
DB09167
The metabolism of Dosulepin can be increased when combined with Butalbital.
DB09307
The metabolism of Oxaprotiline can be increased when combined with Butalbital.
DB12930
The metabolism of Opipramol can be increased when combined with Butalbital.
DB13114
The metabolism of Amitriptylinoxide can be increased when combined with Butalbital.
DB13225
The metabolism of Dibenzepin can be increased when combined with Butalbital.
DB13246
The metabolism of Quinupramine can be increased when combined with Butalbital.
DB13384
The metabolism of Melitracen can be increased when combined with Butalbital.
DB13411
The metabolism of Lofepramine can be increased when combined with Butalbital.
DB13496
The metabolism of Iprindole can be increased when combined with Butalbital.
DB13782
The metabolism of Imipramine oxide can be increased when combined with Butalbital.
DB00266
The metabolism of Dicoumarol can be increased when combined with Butalbital.
DB00498
The metabolism of Phenindione can be increased when combined with Butalbital.
DB04665
The metabolism of Coumarin can be increased when combined with Butalbital.
DB13451
The metabolism of Tioclomarol can be increased when combined with Butalbital.
DB08794
The metabolism of Ethyl biscoumacetate can be increased when combined with Butalbital.
DB13347
The metabolism of Diphenadione can be increased when combined with Butalbital.
DB03410
The metabolism of 4-hydroxycoumarin can be increased when combined with Butalbital.
DB13136
The metabolism of Fluindione can be increased when combined with Butalbital.
DB13275
The metabolism of Clorindione can be increased when combined with Butalbital.
DB00250
The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Butalbital.
DB00530
The serum concentration of Erlotinib can be decreased when it is combined with Butalbital.
DB00082
The therapeutic efficacy of Butalbital can be decreased when used in combination with Pegvisomant.
DB00382
The therapeutic efficacy of Butalbital can be decreased when used in combination with Tacrine.
DB00515
The therapeutic efficacy of Butalbital can be decreased when used in combination with Cisplatin.
DB00527
The therapeutic efficacy of Butalbital can be decreased when used in combination with Cinchocaine.
DB00545
The therapeutic efficacy of Butalbital can be decreased when used in combination with Pyridostigmine.
DB00585
The therapeutic efficacy of Butalbital can be decreased when used in combination with Nizatidine.
DB00674
The therapeutic efficacy of Butalbital can be decreased when used in combination with Galantamine.
DB00677
The therapeutic efficacy of Butalbital can be decreased when used in combination with Isoflurophate.
DB00711
The therapeutic efficacy of Butalbital can be decreased when used in combination with Diethylcarbamazine.
DB00871
The therapeutic efficacy of Butalbital can be decreased when used in combination with Terbutaline.
DB00888
The therapeutic efficacy of Butalbital can be decreased when used in combination with Mechlorethamine.
DB00944
The therapeutic efficacy of Butalbital can be decreased when used in combination with Demecarium.
DB00981
The therapeutic efficacy of Butalbital can be decreased when used in combination with Physostigmine.
DB00989
The therapeutic efficacy of Butalbital can be decreased when used in combination with Rivastigmine.
DB01010
The therapeutic efficacy of Butalbital can be decreased when used in combination with Edrophonium.
DB01035
The therapeutic efficacy of Butalbital can be decreased when used in combination with Procainamide.
DB01043
The therapeutic efficacy of Butalbital can be decreased when used in combination with Memantine.
DB01122
The therapeutic efficacy of Butalbital can be decreased when used in combination with Ambenonium.
DB01381
The therapeutic efficacy of Butalbital can be decreased when used in combination with Ginkgo biloba.
DB01400
The therapeutic efficacy of Butalbital can be decreased when used in combination with Neostigmine.
DB01408
The therapeutic efficacy of Butalbital can be decreased when used in combination with Bambuterol.
DB02365
The therapeutic efficacy of Butalbital can be decreased when used in combination with 1,10-Phenanthroline.
DB04864
The therapeutic efficacy of Butalbital can be decreased when used in combination with Huperzine A.
DB04892
The therapeutic efficacy of Butalbital can be decreased when used in combination with Phenserine.
DB05386
The therapeutic efficacy of Butalbital can be decreased when used in combination with Regramostim.
DB06692
The therapeutic efficacy of Butalbital can be decreased when used in combination with Aprotinin.
DB06756
The therapeutic efficacy of Butalbital can be decreased when used in combination with Glycine betaine.
DB06774
The therapeutic efficacy of Butalbital can be decreased when used in combination with Capsaicin.
DB11390
The therapeutic efficacy of Butalbital can be decreased when used in combination with Coumaphos.
DB11397
The therapeutic efficacy of Butalbital can be decreased when used in combination with Dichlorvos.
DB11412
The therapeutic efficacy of Butalbital can be decreased when used in combination with Fenthion.
DB11473
The therapeutic efficacy of Butalbital can be decreased when used in combination with Metrifonate.
DB12482
The therapeutic efficacy of Butalbital can be decreased when used in combination with Acotiamide.
DB13058
The therapeutic efficacy of Butalbital can be decreased when used in combination with Methanesulfonyl Fluoride.
DB13495
The therapeutic efficacy of Butalbital can be decreased when used in combination with Paraoxon.
DB13503
The therapeutic efficacy of Butalbital can be decreased when used in combination with Tyrothricin.
DB13668
The therapeutic efficacy of Butalbital can be decreased when used in combination with Ipidacrine.
DB13694
The therapeutic efficacy of Butalbital can be decreased when used in combination with Distigmine.
DB14031
The therapeutic efficacy of Butalbital can be decreased when used in combination with Tretamine.
DB15317
The therapeutic efficacy of Butalbital can be decreased when used in combination with Posiphen.
DB02845
The therapeutic efficacy of Butalbital can be decreased when used in combination with Methylphosphinic Acid.
DB00392
Profenamine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00483
Gallamine triethiodide may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00508
Triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB01337
Pancuronium may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB01338
Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
DB00209
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
DB00219
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Oxyphenonium.
DB00245
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
DB00332
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Ipratropium.
DB00340
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Metixene.
DB00354
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Buclizine.
DB00376
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
DB00383
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Oxyphencyclimine.
DB00387
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Procyclidine.
DB00424
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
DB00434
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
DB00462
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Methscopolamine bromide.
DB00505
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Tridihexethyl.
DB00517
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Anisotropine methylbromide.
DB00572
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Atropine.
DB00670
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Pirenzepine.
DB00725
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Homatropine methylbromide.
DB00767
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Benzquinamide.
DB00777
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
DB00782
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
DB00804
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
DB00810
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Biperiden.
DB00934
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
DB00940
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Methantheline.
DB00942
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Cycrimine.
DB00986
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
DB01148
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
DB01231
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Diphenidol.
DB01625
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Isopropamide.
DB04843
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Mepenzolate.
DB06153
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.
DB06787
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
DB08801
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Dimetindene.
DB08897
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
DB08997
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Dexetimide.
DB09076
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Umeclidinium.
DB09300
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Butylscopolamine.
DB11235
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Thonzylamine.
DB11315
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Methscopolamine.
DB11855
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Revefenacin.
DB12086
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Oxitropium.
DB12526
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Batefenterol.
DB12554
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Mebeverine.
DB13252
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Tropatepine.
DB13254
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Prifinium.
DB13351
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Piperidolate.
DB13369
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Benzilone.
DB13380
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Difemerine.
DB13413
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Phenglutarimide.
DB13448
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Mazaticol.
DB13468
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Etybenzatropine.
DB13507
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Poldine.
DB13542
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Bevonium.
DB13581
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Rociverine.
DB13619
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Bornaprine.
DB13636
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Etanautine.
DB13666
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Tiemonium iodide.
DB13678
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Dihexyverine.
DB13695
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Penthienate.
DB13720
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Diphemanil.
DB13738
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Camylofin.
DB13759
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Fenpiverinium.
DB13769
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Emetonium iodide.
DB13844
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Pipenzolate.
DB13850
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Timepidium.
DB00280
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
DB00907
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Cocaine.
DB01036
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
DB01062
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
DB01224
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
DB01409
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Tiotropium.
DB01591
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
DB06702
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
DB09262
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Imidafenacin.
DB12278
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Propiverine.
DB00321
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
DB00458
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
DB01142
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DB00496
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
DB09007
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Chlorphenoxamine.
DB00342
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Terfenadine.
DB00363
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
DB00178
Ramipril may increase the hypotensive activities of Butalbital.
DB00477
Chlorpromazine may increase the hypotensive activities of Butalbital.
DB00790
Perindopril may increase the hypotensive activities of Butalbital.
DB00041
Butalbital may increase the hypotensive activities of Aldesleukin.
DB00086
Butalbital may increase the hypotensive activities of Streptokinase.
DB00177
Butalbital may increase the hypotensive activities of Valsartan.
DB00206
Butalbital may increase the hypotensive activities of Reserpine.
DB00214
Butalbital may increase the hypotensive activities of Torasemide.
DB00275
Butalbital may increase the hypotensive activities of Olmesartan.
DB00296
Butalbital may increase the hypotensive activities of Ropivacaine.
DB00297
Butalbital may increase the hypotensive activities of Bupivacaine.
DB00350
Butalbital may increase the hypotensive activities of Minoxidil.
DB00384
Butalbital may increase the hypotensive activities of Triamterene.
DB00421
Butalbital may increase the hypotensive activities of Spironolactone.
DB00457
Butalbital may increase the hypotensive activities of Prazosin.
DB00492
Butalbital may increase the hypotensive activities of Fosinopril.
DB00519
Butalbital may increase the hypotensive activities of Trandolapril.
DB00542
Butalbital may increase the hypotensive activities of Benazepril.
DB00584
Butalbital may increase the hypotensive activities of Enalapril.
DB00590
Butalbital may increase the hypotensive activities of Doxazosin.
DB00594
Butalbital may increase the hypotensive activities of Amiloride.
DB00631
Butalbital may increase the hypotensive activities of Clofarabine.
DB00657
Butalbital may increase the hypotensive activities of Mecamylamine.
DB00678
Butalbital may increase the hypotensive activities of Losartan.
DB00681
Butalbital may increase the hypotensive activities of Amphotericin B.
DB00691
Butalbital may increase the hypotensive activities of Moexipril.
DB00692
Butalbital may increase the hypotensive activities of Phentolamine.
DB00695
Butalbital may increase the hypotensive activities of Furosemide.
DB00703
Butalbital may increase the hypotensive activities of Methazolamide.
DB00706
Butalbital may increase the hypotensive activities of Tamsulosin.
DB00714
Butalbital may increase the hypotensive activities of Apomorphine.
DB00722
Butalbital may increase the hypotensive activities of Lisinopril.
DB00742
Butalbital may increase the hypotensive activities of Mannitol.
DB00752
Butalbital may increase the hypotensive activities of Tranylcypromine.
DB00755
Butalbital may increase the hypotensive activities of Tretinoin.
DB00780
Butalbital may increase the hypotensive activities of Phenelzine.
DB00796
Butalbital may increase the hypotensive activities of Candesartan cilexetil.
DB00797
Butalbital may increase the hypotensive activities of Tolazoline.
DB00800
Butalbital may increase the hypotensive activities of Fenoldopam.
DB00876
Butalbital may increase the hypotensive activities of Eprosartan.
DB00881
Butalbital may increase the hypotensive activities of Quinapril.
DB00887
Butalbital may increase the hypotensive activities of Bumetanide.
DB00903
Butalbital may increase the hypotensive activities of Etacrynic acid.
DB00922
Butalbital may increase the hypotensive activities of Levosimendan.
DB00925
Butalbital may increase the hypotensive activities of Phenoxybenzamine.
DB00966
Butalbital may increase the hypotensive activities of Telmisartan.
DB00968
Butalbital may increase the hypotensive activities of Methyldopa.
DB00975
Butalbital may increase the hypotensive activities of Dipyridamole.
DB01002
Butalbital may increase the hypotensive activities of Levobupivacaine.
DB01029
Butalbital may increase the hypotensive activities of Irbesartan.
DB01037
Butalbital may increase the hypotensive activities of Selegiline.
DB01088
Butalbital may increase the hypotensive activities of Iloprost.
DB01113
Butalbital may increase the hypotensive activities of Papaverine.
DB01119
Butalbital may increase the hypotensive activities of Diazoxide.
DB01143
Butalbital may increase the hypotensive activities of Amifostine.
DB01144
Butalbital may increase the hypotensive activities of Diclofenamide.
DB01158
Butalbital may increase the hypotensive activities of Bretylium.
DB01162
Butalbital may increase the hypotensive activities of Terazosin.
DB01169
Butalbital may increase the hypotensive activities of Arsenic trioxide.
DB01197
Butalbital may increase the hypotensive activities of Captopril.
DB01240
Butalbital may increase the hypotensive activities of Epoprostenol.
DB01247
Butalbital may increase the hypotensive activities of Isocarboxazid.
DB01275
Butalbital may increase the hypotensive activities of Hydralazine.
DB01282
Butalbital may increase the hypotensive activities of Carbetocin.
DB01340
Butalbital may increase the hypotensive activities of Cilazapril.
DB01367
Butalbital may increase the hypotensive activities of Rasagiline.
DB04899
Butalbital may increase the hypotensive activities of Nesiritide.
DB06292
Butalbital may increase the hypotensive activities of Dapagliflozin.
DB08822
Butalbital may increase the hypotensive activities of Azilsartan medoxomil.
DB08931
Butalbital may increase the hypotensive activities of Riociguat.
DB08935
Butalbital may increase the hypotensive activities of Obinutuzumab.
DB08941
Butalbital may increase the hypotensive activities of Isoxsuprine.
DB08950
Butalbital may increase the hypotensive activities of Indoramin.
DB09026
Butalbital may increase the hypotensive activities of Aliskiren.
DB09038
Butalbital may increase the hypotensive activities of Empagliflozin.
DB09077
Butalbital may increase the hypotensive activities of Dinutuximab.
DB09112
Butalbital may increase the hypotensive activities of Nitrous acid.
DB09242
Butalbital may increase the hypotensive activities of Moxonidine.
DB09279
Butalbital may increase the hypotensive activities of Fimasartan.
DB09286
Butalbital may increase the hypotensive activities of Pipamperone.
DB09292
Butalbital may increase the hypotensive activities of Sacubitril.
DB09477
Butalbital may increase the hypotensive activities of Enalaprilat.
DB11783
Butalbital may increase the hypotensive activities of Imidapril.
DB01115
Butalbital may increase the hypotensive activities of Nifedipine.
DB00401
Butalbital may increase the hypotensive activities of Nisoldipine.
DB00700
Butalbital may increase the hypotensive activities of Eplerenone.
DB01023
Butalbital may increase the hypotensive activities of Felodipine.
DB00187
The serum concentration of Esmolol can be decreased when it is combined with Butalbital.
DB00195
The serum concentration of Betaxolol can be decreased when it is combined with Butalbital.
DB00264
The serum concentration of Metoprolol can be decreased when it is combined with Butalbital.
DB00335
The serum concentration of Atenolol can be decreased when it is combined with Butalbital.
DB00373
The serum concentration of Timolol can be decreased when it is combined with Butalbital.
DB00489
The serum concentration of Sotalol can be decreased when it is combined with Butalbital.
DB00571
The serum concentration of Propranolol can be decreased when it is combined with Butalbital.
DB00598
The serum concentration of Labetalol can be decreased when it is combined with Butalbital.
DB00612
The serum concentration of Bisoprolol can be decreased when it is combined with Butalbital.
DB00866
The serum concentration of Alprenolol can be decreased when it is combined with Butalbital.
DB00960
The serum concentration of Pindolol can be decreased when it is combined with Butalbital.
DB01136
The serum concentration of Carvedilol can be decreased when it is combined with Butalbital.
DB01182
The serum concentration of Propafenone can be decreased when it is combined with Butalbital.
DB01193
The serum concentration of Acebutolol can be decreased when it is combined with Butalbital.
DB01203
The serum concentration of Nadolol can be decreased when it is combined with Butalbital.
DB01295
The serum concentration of Bevantolol can be decreased when it is combined with Butalbital.
DB01297
The serum concentration of Practolol can be decreased when it is combined with Butalbital.
DB01359
The serum concentration of Penbutolol can be decreased when it is combined with Butalbital.
DB01580
The serum concentration of Oxprenolol can be decreased when it is combined with Butalbital.
DB03322
The serum concentration of Dexpropranolol can be decreased when it is combined with Butalbital.
DB04846
The serum concentration of Celiprolol can be decreased when it is combined with Butalbital.
DB04861
The serum concentration of Nebivolol can be decreased when it is combined with Butalbital.
DB06726
The serum concentration of Bufuralol can be decreased when it is combined with Butalbital.
DB08807
The serum concentration of Bopindolol can be decreased when it is combined with Butalbital.
DB08808
The serum concentration of Bupranolol can be decreased when it is combined with Butalbital.
DB08952
The serum concentration of Indenolol can be decreased when it is combined with Butalbital.
DB09204
The serum concentration of Arotinolol can be decreased when it is combined with Butalbital.
DB09351
The serum concentration of Levobetaxolol can be decreased when it is combined with Butalbital.
DB11770
The serum concentration of Talinolol can be decreased when it is combined with Butalbital.
DB11785
The serum concentration of Anisodamine can be decreased when it is combined with Butalbital.
DB12752
The serum concentration of Bucindolol can be decreased when it is combined with Butalbital.
DB13443
The serum concentration of Esatenolol can be decreased when it is combined with Butalbital.
DB13508
The serum concentration of Cloranolol can be decreased when it is combined with Butalbital.
DB13530
The serum concentration of Mepindolol can be decreased when it is combined with Butalbital.
DB13757
The serum concentration of Epanolol can be decreased when it is combined with Butalbital.
DB13775
The serum concentration of Tertatolol can be decreased when it is combined with Butalbital.
DB12212
The serum concentration of Landiolol can be decreased when it is combined with Butalbital.
DB00270
The metabolism of Isradipine can be increased when combined with Butalbital.
DB00343
The metabolism of Diltiazem can be increased when combined with Butalbital.
DB00393
The metabolism of Nimodipine can be increased when combined with Butalbital.
DB00528
The metabolism of Lercanidipine can be increased when combined with Butalbital.
DB00568
The metabolism of Cinnarizine can be increased when combined with Butalbital.
DB00622
The metabolism of Nicardipine can be increased when combined with Butalbital.
DB00661
The metabolism of Verapamil can be increased when combined with Butalbital.
DB00836
The metabolism of Loperamide can be increased when combined with Butalbital.
DB01054
The metabolism of Nitrendipine can be increased when combined with Butalbital.
DB01244
The metabolism of Bepridil can be increased when combined with Butalbital.
DB01388
The metabolism of Mibefradil can be increased when combined with Butalbital.
DB04743
The metabolism of Nimesulide can be increased when combined with Butalbital.
DB04825
The metabolism of Prenylamine can be increased when combined with Butalbital.
DB04838
The metabolism of Cyclandelate can be increased when combined with Butalbital.
DB04842
The metabolism of Fluspirilene can be increased when combined with Butalbital.
DB04920
The metabolism of Clevidipine can be increased when combined with Butalbital.
DB05885
The metabolism of Seletracetam can be increased when combined with Butalbital.
DB06152
The metabolism of Nylidrin can be increased when combined with Butalbital.
DB06446
The metabolism of Dotarizine can be increased when combined with Butalbital.
DB06694
The metabolism of Xylometazoline can be increased when combined with Butalbital.
DB06712
The metabolism of Nilvadipine can be increased when combined with Butalbital.
DB07615
The metabolism of Tranilast can be increased when combined with Butalbital.
DB08162
The metabolism of Fasudil can be increased when combined with Butalbital.
DB08838
The metabolism of Agmatine can be increased when combined with Butalbital.
DB08980
The metabolism of Fendiline can be increased when combined with Butalbital.
DB09089
The metabolism of Trimebutine can be increased when combined with Butalbital.
DB09090
The metabolism of Pinaverium can be increased when combined with Butalbital.
DB09216
The metabolism of Tolfenamic acid can be increased when combined with Butalbital.
DB09227
The metabolism of Barnidipine can be increased when combined with Butalbital.
DB09229
The metabolism of Aranidipine can be increased when combined with Butalbital.
DB09230
The metabolism of Azelnidipine can be increased when combined with Butalbital.
DB09231
The metabolism of Benidipine can be increased when combined with Butalbital.
DB09232
The metabolism of Cilnidipine can be increased when combined with Butalbital.
DB09234
The metabolism of Darodipine can be increased when combined with Butalbital.
DB09235
The metabolism of Efonidipine can be increased when combined with Butalbital.
DB09236
The metabolism of Lacidipine can be increased when combined with Butalbital.
DB09238
The metabolism of Manidipine can be increased when combined with Butalbital.
DB09239
The metabolism of Niguldipine can be increased when combined with Butalbital.
DB09240
The metabolism of Niludipine can be increased when combined with Butalbital.
DB11960
The metabolism of Carboxyamidotriazole can be increased when combined with Butalbital.
DB12092
The metabolism of Naftopidil can be increased when combined with Butalbital.
DB12923
The metabolism of Gallopamil can be increased when combined with Butalbital.
DB13488
The metabolism of Bencyclane can be increased when combined with Butalbital.
DB13500
The metabolism of Otilonium can be increased when combined with Butalbital.
DB13725
The metabolism of Terodiline can be increased when combined with Butalbital.
DB13766
The metabolism of Lidoflazine can be increased when combined with Butalbital.
DB13835
The metabolism of Caroverine can be increased when combined with Butalbital.
DB13961
The metabolism of Fish oil can be increased when combined with Butalbital.
DB14063
The metabolism of Dexverapamil can be increased when combined with Butalbital.
DB14064
The metabolism of Emopamil can be increased when combined with Butalbital.
DB14065
The metabolism of Lomerizine can be increased when combined with Butalbital.
DB14066
The metabolism of Tetrandrine can be increased when combined with Butalbital.
DB14068
The metabolism of Dexniguldipine can be increased when combined with Butalbital.
DB01074
The metabolism of Perhexiline can be increased when combined with Butalbital.
DB00651
The serum concentration of Dyphylline can be decreased when it is combined with Butalbital.
DB00806
The serum concentration of Pentoxifylline can be decreased when it is combined with Butalbital.
DB01033
The serum concentration of Mercaptopurine can be decreased when it is combined with Butalbital.
DB01303
The serum concentration of Oxtriphylline can be decreased when it is combined with Butalbital.
DB01412
The serum concentration of Theobromine can be decreased when it is combined with Butalbital.
DB01482
The serum concentration of Fenethylline can be decreased when it is combined with Butalbital.
DB01667
The serum concentration of 8-azaguanine can be decreased when it is combined with Butalbital.
DB01978
The serum concentration of 7,9-Dimethylguanine can be decreased when it is combined with Butalbital.
DB02134
The serum concentration of Xanthine can be decreased when it is combined with Butalbital.
DB02245
The serum concentration of 7-Deazaguanine can be decreased when it is combined with Butalbital.
DB02377
The serum concentration of Guanine can be decreased when it is combined with Butalbital.
DB02489
The serum concentration of 9-Methylguanine can be decreased when it is combined with Butalbital.
DB02568
The serum concentration of Peldesine can be decreased when it is combined with Butalbital.
DB04076
The serum concentration of Hypoxanthine can be decreased when it is combined with Butalbital.
DB04356
The serum concentration of 9-Deazaguanine can be decreased when it is combined with Butalbital.
DB06479
The serum concentration of Propentofylline can be decreased when it is combined with Butalbital.
DB06575
The serum concentration of Valomaciclovir can be decreased when it is combined with Butalbital.
DB07954
The serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be decreased when it is combined with Butalbital.
DB08844
The serum concentration of Uric acid can be decreased when it is combined with Butalbital.
DB09273
The serum concentration of Doxofylline can be decreased when it is combined with Butalbital.
DB11919
The serum concentration of 6-O-benzylguanine can be decreased when it is combined with Butalbital.
DB12406
The serum concentration of Lisofylline can be decreased when it is combined with Butalbital.
DB12531
The serum concentration of Lobucavir can be decreased when it is combined with Butalbital.
DB12926
The serum concentration of Cafedrine can be decreased when it is combined with Butalbital.
DB12927
The serum concentration of Theodrenaline can be decreased when it is combined with Butalbital.
DB13203
The serum concentration of Bamifylline can be decreased when it is combined with Butalbital.
DB13449
The serum concentration of Proxyphylline can be decreased when it is combined with Butalbital.
DB13573
The serum concentration of Acefylline can be decreased when it is combined with Butalbital.
DB13592
The serum concentration of Etamiphylline can be decreased when it is combined with Butalbital.
DB13634
The serum concentration of Pentifylline can be decreased when it is combined with Butalbital.
DB13812
The serum concentration of Bufylline can be decreased when it is combined with Butalbital.
DB14018
The serum concentration of Bromotheophylline can be decreased when it is combined with Butalbital.
DB14029
The serum concentration of Furafylline can be decreased when it is combined with Butalbital.
DB14132
The serum concentration of 8-chlorotheophylline can be decreased when it is combined with Butalbital.
DB15122
The serum concentration of PCS-499 can be decreased when it is combined with Butalbital.
DB00313
The serum concentration of Butalbital can be increased when it is combined with Valproic acid.
DB00391
The risk or severity of adverse effects can be increased when Sulpiride is combined with Butalbital.
DB00721
The risk or severity of adverse effects can be increased when Procaine is combined with Butalbital.
DB00805
The risk or severity of adverse effects can be increased when Minaprine is combined with Butalbital.
DB00941
The risk or severity of adverse effects can be increased when Hexafluronium is combined with Butalbital.
DB01199
The risk or severity of adverse effects can be increased when Tubocurarine is combined with Butalbital.
DB01221
The risk or severity of adverse effects can be increased when Ketamine is combined with Butalbital.
DB01245
The risk or severity of adverse effects can be increased when Decamethonium is combined with Butalbital.
DB00150
The risk or severity of adverse effects can be increased when Tryptophan is combined with Butalbital.
DB00181
The risk or severity of adverse effects can be increased when Baclofen is combined with Butalbital.
DB00182
The risk or severity of adverse effects can be increased when Amphetamine is combined with Butalbital.
DB00186
The risk or severity of adverse effects can be increased when Lorazepam is combined with Butalbital.
DB00189
The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Butalbital.
DB00202
The risk or severity of adverse effects can be increased when Succinylcholine is combined with Butalbital.
DB00228
The risk or severity of adverse effects can be increased when Enflurane is combined with Butalbital.
DB00231
The risk or severity of adverse effects can be increased when Temazepam is combined with Butalbital.
DB00234
The risk or severity of adverse effects can be increased when Reboxetine is combined with Butalbital.
DB00237
The risk or severity of adverse effects can be increased when Butabarbital is combined with Butalbital.
DB00273
The risk or severity of adverse effects can be increased when Butalbital is combined with Topiramate.
DB00283
The risk or severity of adverse effects can be increased when Butalbital is combined with Clemastine.
DB00285
The risk or severity of adverse effects can be increased when Butalbital is combined with Venlafaxine.
DB00289
The risk or severity of adverse effects can be increased when Butalbital is combined with Atomoxetine.
DB00292
The risk or severity of adverse effects can be increased when Butalbital is combined with Etomidate.
DB00306
The risk or severity of adverse effects can be increased when Butalbital is combined with Talbutal.
DB00312
The risk or severity of adverse effects can be increased when Butalbital is combined with Pentobarbital.
DB00315
The risk or severity of adverse effects can be increased when Butalbital is combined with Zolmitriptan.
DB00323
The risk or severity of adverse effects can be increased when Butalbital is combined with Tolcapone.
DB00334
The risk or severity of adverse effects can be increased when Butalbital is combined with Olanzapine.
DB00341
The risk or severity of adverse effects can be increased when Butalbital is combined with Cetirizine.
DB00347
The risk or severity of adverse effects can be increased when Butalbital is combined with Trimethadione.
DB00349
The risk or severity of adverse effects can be increased when Butalbital is combined with Clobazam.
DB00356
The risk or severity of adverse effects can be increased when Butalbital is combined with Chlorzoxazone.
DB00371
The risk or severity of adverse effects can be increased when Butalbital is combined with Meprobamate.
DB00372
The risk or severity of adverse effects can be increased when Butalbital is combined with Thiethylperazine.
DB00377
The risk or severity of adverse effects can be increased when Butalbital is combined with Palonosetron.
DB00405
The risk or severity of adverse effects can be increased when Butalbital is combined with Dexbrompheniramine.
DB00408
The risk or severity of adverse effects can be increased when Butalbital is combined with Loxapine.
DB00409
The risk or severity of adverse effects can be increased when Butalbital is combined with Remoxipride.
DB00416
The risk or severity of adverse effects can be increased when Butalbital is combined with Metocurine iodide.
DB00418
The risk or severity of adverse effects can be increased when Butalbital is combined with Secobarbital.
DB00420
The risk or severity of adverse effects can be increased when Butalbital is combined with Promazine.
DB00423
The risk or severity of adverse effects can be increased when Butalbital is combined with Methocarbamol.
DB00427
The risk or severity of adverse effects can be increased when Butalbital is combined with Triprolidine.
DB00433
The risk or severity of adverse effects can be increased when Butalbital is combined with Prochlorperazine.
DB00463
The risk or severity of adverse effects can be increased when Butalbital is combined with Metharbital.
DB00474
The risk or severity of adverse effects can be increased when Butalbital is combined with Methohexital.
DB00475
The risk or severity of adverse effects can be increased when Butalbital is combined with Chlordiazepoxide.
DB00494
The risk or severity of adverse effects can be increased when Butalbital is combined with Entacapone.
DB00514
The risk or severity of adverse effects can be increased when Butalbital is combined with Dextromethorphan.
DB00532
The risk or severity of adverse effects can be increased when Butalbital is combined with Mephenytoin.
DB00546
The risk or severity of adverse effects can be increased when Butalbital is combined with Adinazolam.
DB00565
The risk or severity of adverse effects can be increased when Butalbital is combined with Cisatracurium.
DB00574
The risk or severity of adverse effects can be increased when Butalbital is combined with Fenfluramine.
DB00579
The risk or severity of adverse effects can be increased when Butalbital is combined with Mazindol.
DB00588
The risk or severity of adverse effects can be increased when Butalbital is combined with Fluticasone propionate.
DB00589
The risk or severity of adverse effects can be increased when Butalbital is combined with Lisuride.
DB00599
The risk or severity of adverse effects can be increased when Butalbital is combined with Thiopental.
DB00601
The risk or severity of adverse effects can be increased when Butalbital is combined with Linezolid.
DB00614
The risk or severity of adverse effects can be increased when Butalbital is combined with Furazolidone.
DB00617
The risk or severity of adverse effects can be increased when Butalbital is combined with Paramethadione.
DB00623
The risk or severity of adverse effects can be increased when Butalbital is combined with Fluphenazine.
DB00625
The risk or severity of adverse effects can be increased when Butalbital is combined with Efavirenz.
DB00628
The risk or severity of adverse effects can be increased when Butalbital is combined with Clorazepic acid.
DB00633
The risk or severity of adverse effects can be increased when Butalbital is combined with Dexmedetomidine.
DB00645
The risk or severity of adverse effects can be increased when Butalbital is combined with Dyclonine.
DB00660
The risk or severity of adverse effects can be increased when Butalbital is combined with Metaxalone.
DB00662
The risk or severity of adverse effects can be increased when Butalbital is combined with Trimethobenzamide.
DB00669
The risk or severity of adverse effects can be increased when Butalbital is combined with Sumatriptan.
DB00679
The risk or severity of adverse effects can be increased when Butalbital is combined with Thioridazine.
DB00680
The risk or severity of adverse effects can be increased when Butalbital is combined with Moricizine.
DB00690
The risk or severity of adverse effects can be increased when Butalbital is combined with Flurazepam.
DB00697
The risk or severity of adverse effects can be increased when Butalbital is combined with Tizanidine.
DB00728
The risk or severity of adverse effects can be increased when Butalbital is combined with Rocuronium.
DB00732
The risk or severity of adverse effects can be increased when Butalbital is combined with Atracurium besylate.
DB00734
The risk or severity of adverse effects can be increased when Butalbital is combined with Risperidone.
DB00737
The risk or severity of adverse effects can be increased when Butalbital is combined with Meclizine.
DB00740
The risk or severity of adverse effects can be increased when Butalbital is combined with Riluzole.
DB00747
The risk or severity of adverse effects can be increased when Butalbital is combined with Scopolamine.
DB00748
The risk or severity of adverse effects can be increased when Butalbital is combined with Carbinoxamine.
DB00753
The risk or severity of adverse effects can be increased when Butalbital is combined with Isoflurane.
DB00754
The risk or severity of adverse effects can be increased when Butalbital is combined with Ethotoin.
DB00757
The risk or severity of adverse effects can be increased when Butalbital is combined with Dolasetron.
DB00771
The risk or severity of adverse effects can be increased when Butalbital is combined with Clidinium.
DB00776
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxcarbazepine.
DB00801
The risk or severity of adverse effects can be increased when Butalbital is combined with Halazepam.
DB00818
The risk or severity of adverse effects can be increased when Butalbital is combined with Propofol.
DB00819
The risk or severity of adverse effects can be increased when Butalbital is combined with Acetazolamide.
DB00829
The risk or severity of adverse effects can be increased when Butalbital is combined with Diazepam.
DB00831
The risk or severity of adverse effects can be increased when Butalbital is combined with Trifluoperazine.
DB00832
The risk or severity of adverse effects can be increased when Butalbital is combined with Phensuximide.
DB00835
The risk or severity of adverse effects can be increased when Butalbital is combined with Brompheniramine.
DB00837
The risk or severity of adverse effects can be increased when Butalbital is combined with Progabide.
DB00842
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxazepam.
DB00850
The risk or severity of adverse effects can be increased when Butalbital is combined with Perphenazine.
DB00865
The risk or severity of adverse effects can be increased when Butalbital is combined with Benzphetamine.
DB00875
The risk or severity of adverse effects can be increased when Butalbital is combined with Flupentixol.
DB00889
The risk or severity of adverse effects can be increased when Butalbital is combined with Granisetron.
DB00904
The risk or severity of adverse effects can be increased when Butalbital is combined with Ondansetron.
DB00906
The risk or severity of adverse effects can be increased when Butalbital is combined with Tiagabine.
DB00909
The risk or severity of adverse effects can be increased when Butalbital is combined with Zonisamide.
DB00918
The risk or severity of adverse effects can be increased when Butalbital is combined with Almotriptan.
DB00933
The risk or severity of adverse effects can be increased when Butalbital is combined with Mesoridazine.
DB00937
The risk or severity of adverse effects can be increased when Butalbital is combined with Diethylpropion.
DB00952
The risk or severity of adverse effects can be increased when Butalbital is combined with Naratriptan.
DB00953
The risk or severity of adverse effects can be increased when Butalbital is combined with Rizatriptan.
DB00962
The risk or severity of adverse effects can be increased when Butalbital is combined with Zaleplon.
DB00969
The risk or severity of adverse effects can be increased when Butalbital is combined with Alosetron.
DB00980
The risk or severity of adverse effects can be increased when Butalbital is combined with Ramelteon.
DB00985
The risk or severity of adverse effects can be increased when Butalbital is combined with Dimenhydrinate.
DB00996
The risk or severity of adverse effects can be increased when Butalbital is combined with Gabapentin.
DB00998
The risk or severity of adverse effects can be increased when Butalbital is combined with Frovatriptan.
DB01018
The risk or severity of adverse effects can be increased when Butalbital is combined with Guanfacine.
DB01028
The risk or severity of adverse effects can be increased when Butalbital is combined with Methoxyflurane.
DB01049
The risk or severity of adverse effects can be increased when Butalbital is combined with Ergoloid mesylate.
DB01063
The risk or severity of adverse effects can be increased when Butalbital is combined with Acetophenazine.
DB01065
The risk or severity of adverse effects can be increased when Butalbital is combined with Melatonin.
DB01069
The risk or severity of adverse effects can be increased when Butalbital is combined with Promethazine.
DB01075
The risk or severity of adverse effects can be increased when Butalbital is combined with Diphenhydramine.
DB01080
The risk or severity of adverse effects can be increased when Butalbital is combined with Vigabatrin.
DB01107
The risk or severity of adverse effects can be increased when Butalbital is combined with Methyprylon.
DB01114
The risk or severity of adverse effects can be increased when Butalbital is combined with Chlorpheniramine.
DB01121
The risk or severity of adverse effects can be increased when Butalbital is combined with Phenacemide.
DB01135
The risk or severity of adverse effects can be increased when Butalbital is combined with Doxacurium.
DB01154
The risk or severity of adverse effects can be increased when Butalbital is combined with Thiamylal.
DB01156
The risk or severity of adverse effects can be increased when Butalbital is combined with Bupropion.
DB01159
The risk or severity of adverse effects can be increased when Butalbital is combined with Halothane.
DB01168
The risk or severity of adverse effects can be increased when Butalbital is combined with Procarbazine.
DB01171
The risk or severity of adverse effects can be increased when Butalbital is combined with Moclobemide.
DB01176
The risk or severity of adverse effects can be increased when Butalbital is combined with Cyclizine.
DB01178
The risk or severity of adverse effects can be increased when Butalbital is combined with Chlormezanone.
DB01186
The risk or severity of adverse effects can be increased when Butalbital is combined with Pergolide.
DB01189
The risk or severity of adverse effects can be increased when Butalbital is combined with Desflurane.
DB01202
The risk or severity of adverse effects can be increased when Butalbital is combined with Levetiracetam.
DB01215
The risk or severity of adverse effects can be increased when Butalbital is combined with Estazolam.
DB01219
The risk or severity of adverse effects can be increased when Butalbital is combined with Dantrolene.
DB01226
The risk or severity of adverse effects can be increased when Butalbital is combined with Mivacurium.
DB01235
The risk or severity of adverse effects can be increased when Butalbital is combined with Levodopa.
DB01236
The risk or severity of adverse effects can be increased when Butalbital is combined with Sevoflurane.
DB01239
The risk or severity of adverse effects can be increased when Butalbital is combined with Chlorprothixene.
DB01246
The risk or severity of adverse effects can be increased when Butalbital is combined with Alimemazine.
DB01253
The risk or severity of adverse effects can be increased when Butalbital is combined with Ergometrine.
DB01267
The risk or severity of adverse effects can be increased when Butalbital is combined with Paliperidone.
DB01323
The risk or severity of adverse effects can be increased when Butalbital is combined with St. John's Wort.
DB01336
The risk or severity of adverse effects can be increased when Butalbital is combined with Metocurine.
DB01339
The risk or severity of adverse effects can be increased when Butalbital is combined with Vecuronium.
DB01351
The risk or severity of adverse effects can be increased when Butalbital is combined with Amobarbital.
DB01352
The risk or severity of adverse effects can be increased when Butalbital is combined with Aprobarbital.
DB01353
The risk or severity of adverse effects can be increased when Butalbital is combined with Butobarbital.
DB01354
The risk or severity of adverse effects can be increased when Butalbital is combined with Heptabarbital.
DB01355
The risk or severity of adverse effects can be increased when Butalbital is combined with Hexobarbital.
DB01392
The risk or severity of adverse effects can be increased when Butalbital is combined with Yohimbine.
DB01437
The risk or severity of adverse effects can be increased when Butalbital is combined with Glutethimide.
DB01440
The risk or severity of adverse effects can be increased when Butalbital is combined with gamma-Hydroxybutyric acid.
DB01442
The risk or severity of adverse effects can be increased when Butalbital is combined with MMDA.
DB01445
The risk or severity of adverse effects can be increased when Butalbital is combined with Bufotenine.
DB01454
The risk or severity of adverse effects can be increased when Butalbital is combined with Midomafetamine.
DB01463
The risk or severity of adverse effects can be increased when Butalbital is combined with Fencamfamin.
DB01472
The risk or severity of adverse effects can be increased when Butalbital is combined with 4-Methoxyamphetamine.
DB01483
The risk or severity of adverse effects can be increased when Butalbital is combined with Barbital.
DB01484
The risk or severity of adverse effects can be increased when Butalbital is combined with 4-Bromo-2,5-dimethoxyamphetamine.
DB01488
The risk or severity of adverse effects can be increased when Butalbital is combined with Dimethyltryptamine.
DB01489
The risk or severity of adverse effects can be increased when Butalbital is combined with Camazepam.
DB01495
The risk or severity of adverse effects can be increased when Butalbital is combined with Dichloralphenazone.
DB01501
The risk or severity of adverse effects can be increased when Butalbital is combined with Difenoxin.
DB01509
The risk or severity of adverse effects can be increased when Butalbital is combined with Tenamfetamine.
DB01511
The risk or severity of adverse effects can be increased when Butalbital is combined with Delorazepam.
DB01534
The risk or severity of adverse effects can be increased when Butalbital is combined with Chlorhexadol.
DB01544
The risk or severity of adverse effects can be increased when Butalbital is combined with Flunitrazepam.
DB01545
The risk or severity of adverse effects can be increased when Butalbital is combined with Ethyl loflazepate.
DB01547
The risk or severity of adverse effects can be increased when Butalbital is combined with Drotebanol.
DB01553
The risk or severity of adverse effects can be increased when Butalbital is combined with Cloxazolam.
DB01558
The risk or severity of adverse effects can be increased when Butalbital is combined with Bromazepam.
DB01559
The risk or severity of adverse effects can be increased when Butalbital is combined with Clotiazepam.
DB01560
The risk or severity of adverse effects can be increased when Butalbital is combined with Cathinone.
DB01563
The risk or severity of adverse effects can be increased when Butalbital is combined with Chloral hydrate.
DB01567
The risk or severity of adverse effects can be increased when Butalbital is combined with Fludiazepam.
DB01577
The risk or severity of adverse effects can be increased when Butalbital is combined with Metamfetamine.
DB01587
The risk or severity of adverse effects can be increased when Butalbital is combined with Ketazolam.
DB01588
The risk or severity of adverse effects can be increased when Butalbital is combined with Prazepam.
DB01589
The risk or severity of adverse effects can be increased when Butalbital is combined with Quazepam.
DB01594
The risk or severity of adverse effects can be increased when Butalbital is combined with Cinolazepam.
DB01595
The risk or severity of adverse effects can be increased when Butalbital is combined with Nitrazepam.
DB01608
The risk or severity of adverse effects can be increased when Butalbital is combined with Periciazine.
DB01614
The risk or severity of adverse effects can be increased when Butalbital is combined with Acepromazine.
DB01615
The risk or severity of adverse effects can be increased when Butalbital is combined with Aceprometazine.
DB01616
The risk or severity of adverse effects can be increased when Butalbital is combined with Alverine.
DB01618
The risk or severity of adverse effects can be increased when Butalbital is combined with Molindone.
DB01621
The risk or severity of adverse effects can be increased when Butalbital is combined with Pipotiazine.
DB01622
The risk or severity of adverse effects can be increased when Butalbital is combined with Thioproperazine.
DB01623
The risk or severity of adverse effects can be increased when Butalbital is combined with Thiothixene.
DB01624
The risk or severity of adverse effects can be increased when Butalbital is combined with Zuclopenthixol.
DB01626
The risk or severity of adverse effects can be increased when Butalbital is combined with Pargyline.
DB01954
The risk or severity of adverse effects can be increased when Butalbital is combined with Rolipram.
DB02207
The risk or severity of adverse effects can be increased when Butalbital is combined with 7-Nitroindazole.
DB02234
The risk or severity of adverse effects can be increased when Butalbital is combined with S-Ethylisothiourea.
DB02852
The risk or severity of adverse effects can be increased when Butalbital is combined with Domoic Acid.
DB02959
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxitriptan.
DB03575
The risk or severity of adverse effects can be increased when Butalbital is combined with Phencyclidine.
DB04017
The risk or severity of adverse effects can be increased when Butalbital is combined with Clorgiline.
DB04165
The risk or severity of adverse effects can be increased when Butalbital is combined with Valpromide.
DB04325
The risk or severity of adverse effects can be increased when Butalbital is combined with Phenethylamine.
DB04599
The risk or severity of adverse effects can be increased when Butalbital is combined with Aniracetam.
DB04818
The risk or severity of adverse effects can be increased when Butalbital is combined with Iproniazid.
DB04819
The risk or severity of adverse effects can be increased when Butalbital is combined with Methapyrilene.
DB04820
The risk or severity of adverse effects can be increased when Butalbital is combined with Nialamide.
DB04821
The risk or severity of adverse effects can be increased when Butalbital is combined with Nomifensine.
DB04827
The risk or severity of adverse effects can be increased when Butalbital is combined with Urethane.
DB04829
The risk or severity of adverse effects can be increased when Butalbital is combined with Lysergic acid diethylamide.
DB04833
The risk or severity of adverse effects can be increased when Butalbital is combined with Methaqualone.
DB04834
The risk or severity of adverse effects can be increased when Butalbital is combined with Rapacuronium.
DB04841
The risk or severity of adverse effects can be increased when Butalbital is combined with Flunarizine.
DB04871
The risk or severity of adverse effects can be increased when Butalbital is combined with Lorcaserin.
DB04872
The risk or severity of adverse effects can be increased when Butalbital is combined with Osanetant.
DB04885
The risk or severity of adverse effects can be increased when Butalbital is combined with Cilansetron.
DB04888
The risk or severity of adverse effects can be increased when Butalbital is combined with Bifeprunox.
DB04903
The risk or severity of adverse effects can be increased when Butalbital is combined with Pagoclone.
DB04908
The risk or severity of adverse effects can be increased when Butalbital is combined with Flibanserin.
DB04917
The risk or severity of adverse effects can be increased when Butalbital is combined with Renzapride.
DB04946
The risk or severity of adverse effects can be increased when Butalbital is combined with Iloperidone.
DB04953
The risk or severity of adverse effects can be increased when Butalbital is combined with Ezogabine.
DB05227
The risk or severity of adverse effects can be increased when Butalbital is combined with APD791.
DB05232
The risk or severity of adverse effects can be increased when Butalbital is combined with Tetrodotoxin.
DB05246
The risk or severity of adverse effects can be increased when Butalbital is combined with Methsuximide.
DB05316
The risk or severity of adverse effects can be increased when Butalbital is combined with Pimavanserin.
DB05541
The risk or severity of adverse effects can be increased when Butalbital is combined with Brivaracetam.
DB05542
The risk or severity of adverse effects can be increased when Butalbital is combined with Naronapride.
DB05562
The risk or severity of adverse effects can be increased when Butalbital is combined with Naluzotan.
DB05607
The risk or severity of adverse effects can be increased when Butalbital is combined with PRX-08066.
DB05687
The risk or severity of adverse effects can be increased when Butalbital is combined with BL-1020.
DB05710
The risk or severity of adverse effects can be increased when Butalbital is combined with Gantacurium.
DB06016
The risk or severity of adverse effects can be increased when Butalbital is combined with Cariprazine.
DB06109
The risk or severity of adverse effects can be increased when Butalbital is combined with YKP-1358.
DB06144
The risk or severity of adverse effects can be increased when Butalbital is combined with Sertindole.
DB06216
The risk or severity of adverse effects can be increased when Butalbital is combined with Asenapine.
DB06218
The risk or severity of adverse effects can be increased when Butalbital is combined with Lacosamide.
DB06264
The risk or severity of adverse effects can be increased when Butalbital is combined with Tolperisone.
DB06282
The risk or severity of adverse effects can be increased when Butalbital is combined with Levocetirizine.
DB06288
The risk or severity of adverse effects can be increased when Butalbital is combined with Amisulpride.
DB06458
The risk or severity of adverse effects can be increased when Butalbital is combined with Remacemide.
DB06470
The risk or severity of adverse effects can be increased when Butalbital is combined with Clomethiazole.
DB06512
The risk or severity of adverse effects can be increased when Butalbital is combined with Deramciclane.
DB06527
The risk or severity of adverse effects can be increased when Butalbital is combined with Tramiprosate.
DB06529
The risk or severity of adverse effects can be increased when Butalbital is combined with Ocinaplon.
DB06554
The risk or severity of adverse effects can be increased when Butalbital is combined with Gaboxadol.
DB06579
The risk or severity of adverse effects can be increased when Butalbital is combined with Adipiplon.
DB06582
The risk or severity of adverse effects can be increased when Butalbital is combined with Dextofisopam.
DB06594
The risk or severity of adverse effects can be increased when Butalbital is combined with Agomelatine.
DB06654
The risk or severity of adverse effects can be increased when Butalbital is combined with Safinamide.
DB06660
The risk or severity of adverse effects can be increased when Butalbital is combined with Saredutant.
DB06678
The risk or severity of adverse effects can be increased when Butalbital is combined with Esmirtazapine.
DB06684
The risk or severity of adverse effects can be increased when Butalbital is combined with Vilazodone.
DB06691
The risk or severity of adverse effects can be increased when Butalbital is combined with Mepyramine.
DB06701
The risk or severity of adverse effects can be increased when Butalbital is combined with Dexmethylphenidate.
DB06716
The risk or severity of adverse effects can be increased when Butalbital is combined with Fospropofol.
DB06753
The risk or severity of adverse effects can be increased when Butalbital is combined with Triclofos.
DB06770
The risk or severity of adverse effects can be increased when Butalbital is combined with Benzyl alcohol.
DB06797
The risk or severity of adverse effects can be increased when Butalbital is combined with Mebutamate.
DB08059
The risk or severity of adverse effects can be increased when Butalbital is combined with Wortmannin.
DB08329
The risk or severity of adverse effects can be increased when Butalbital is combined with Sulthiame.
DB08550
The risk or severity of adverse effects can be increased when Butalbital is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
DB08810
The risk or severity of adverse effects can be increased when Butalbital is combined with Cinitapride.
DB08811
The risk or severity of adverse effects can be increased when Butalbital is combined with Tofisopam.
DB08839
The risk or severity of adverse effects can be increased when Butalbital is combined with Serotonin.
DB08872
The risk or severity of adverse effects can be increased when Butalbital is combined with Gabapentin enacarbil.
DB08892
The risk or severity of adverse effects can be increased when Butalbital is combined with Arbaclofen Placarbil.
DB08922
The risk or severity of adverse effects can be increased when Butalbital is combined with Perospirone.
DB08927
The risk or severity of adverse effects can be increased when Butalbital is combined with Amperozide.
DB08954
The risk or severity of adverse effects can be increased when Butalbital is combined with Ifenprodil.
DB08960
The risk or severity of adverse effects can be increased when Butalbital is combined with Hexamethonium.
DB08986
The risk or severity of adverse effects can be increased when Butalbital is combined with Etifoxine.
DB08992
The risk or severity of adverse effects can be increased when Butalbital is combined with Eperisone.
DB09000
The risk or severity of adverse effects can be increased when Butalbital is combined with Cyamemazine.
DB09001
The risk or severity of adverse effects can be increased when Butalbital is combined with Barbexaclone.
DB09011
The risk or severity of adverse effects can be increased when Butalbital is combined with Beclamide.
DB09014
The risk or severity of adverse effects can be increased when Butalbital is combined with Captodiame.
DB09017
The risk or severity of adverse effects can be increased when Butalbital is combined with Brotizolam.
DB09021
The risk or severity of adverse effects can be increased when Butalbital is combined with Benzoctamine.
DB09023
The risk or severity of adverse effects can be increased when Butalbital is combined with Benactyzine.
DB09068
The risk or severity of adverse effects can be increased when Butalbital is combined with Vortioxetine.
DB09071
The risk or severity of adverse effects can be increased when Butalbital is combined with Tasimelteon.
DB09118
The risk or severity of adverse effects can be increased when Butalbital is combined with Stiripentol.
DB09119
The risk or severity of adverse effects can be increased when Butalbital is combined with Eslicarbazepine acetate.
DB09128
The risk or severity of adverse effects can be increased when Butalbital is combined with Brexpiprazole.
DB09166
The risk or severity of adverse effects can be increased when Butalbital is combined with Etizolam.
DB09184
The risk or severity of adverse effects can be increased when Butalbital is combined with Edivoxetine.
DB09185
The risk or severity of adverse effects can be increased when Butalbital is combined with Viloxazine.
DB09186
The risk or severity of adverse effects can be increased when Butalbital is combined with Nisoxetine.
DB09187
The risk or severity of adverse effects can be increased when Butalbital is combined with Lortalamine.
DB09190
The risk or severity of adverse effects can be increased when Butalbital is combined with Talopram.
DB09194
The risk or severity of adverse effects can be increased when Butalbital is combined with Etoperidone.
DB09223
The risk or severity of adverse effects can be increased when Butalbital is combined with Blonanserin.
DB09224
The risk or severity of adverse effects can be increased when Butalbital is combined with Melperone.
DB09225
The risk or severity of adverse effects can be increased when Butalbital is combined with Zotepine.
DB09226
The risk or severity of adverse effects can be increased when Butalbital is combined with Brilaroxazine.
DB09241
The risk or severity of adverse effects can be increased when Butalbital is combined with Methylene blue.
DB09243
The risk or severity of adverse effects can be increased when Butalbital is combined with Hydracarbazine.
DB09244
The risk or severity of adverse effects can be increased when Butalbital is combined with Pirlindole.
DB09245
The risk or severity of adverse effects can be increased when Butalbital is combined with Toloxatone.
DB09246
The risk or severity of adverse effects can be increased when Butalbital is combined with Benmoxin.
DB09247
The risk or severity of adverse effects can be increased when Butalbital is combined with Iproclozide.
DB09248
The risk or severity of adverse effects can be increased when Butalbital is combined with Mebanazine.
DB09249
The risk or severity of adverse effects can be increased when Butalbital is combined with Octamoxin.
DB09250
The risk or severity of adverse effects can be increased when Butalbital is combined with Pheniprazine.
DB09251
The risk or severity of adverse effects can be increased when Butalbital is combined with Phenoxypropazine.
DB09252
The risk or severity of adverse effects can be increased when Butalbital is combined with Pivhydrazine.
DB09253
The risk or severity of adverse effects can be increased when Butalbital is combined with Safrazine.
DB09254
The risk or severity of adverse effects can be increased when Butalbital is combined with Caroxazone.
DB09290
The risk or severity of adverse effects can be increased when Butalbital is combined with Ramosetron.
DB11156
The risk or severity of adverse effects can be increased when Butalbital is combined with Pyrantel.
DB11371
The risk or severity of adverse effects can be increased when Butalbital is combined with Alfaxalone.
DB11376
The risk or severity of adverse effects can be increased when Butalbital is combined with Azaperone.
DB11400
The risk or severity of adverse effects can be increased when Butalbital is combined with Doramectin.
DB11428
The risk or severity of adverse effects can be increased when Butalbital is combined with Medetomidine.
DB11477
The risk or severity of adverse effects can be increased when Butalbital is combined with Xylazine.
DB11540
The risk or severity of adverse effects can be increased when Butalbital is combined with Propiopromazine.
DB11543
The risk or severity of adverse effects can be increased when Butalbital is combined with Romifidine.
DB11549
The risk or severity of adverse effects can be increased when Butalbital is combined with Tiletamine.
DB11552
The risk or severity of adverse effects can be increased when Butalbital is combined with Tricaine.
DB11555
The risk or severity of adverse effects can be increased when Butalbital is combined with Zolazepam.
DB11556
The risk or severity of adverse effects can be increased when Butalbital is combined with Detomidine.
DB11582
The risk or severity of adverse effects can be increased when Butalbital is combined with Thiocolchicoside.
DB11664
The risk or severity of adverse effects can be increased when Butalbital is combined with Psilocybin.
DB11675
The risk or severity of adverse effects can be increased when Butalbital is combined with Mosapride.
DB11686
The risk or severity of adverse effects can be increased when Butalbital is combined with Iferanserin.
DB11699
The risk or severity of adverse effects can be increased when Butalbital is combined with Tropisetron.
DB11755
The risk or severity of adverse effects can be increased when Butalbital is combined with Tetrahydrocannabivarin.
DB11859
The risk or severity of adverse effects can be increased when Butalbital is combined with Brexanolone.
DB11868
The risk or severity of adverse effects can be increased when Butalbital is combined with Etiracetam.
DB11889
The risk or severity of adverse effects can be increased when Butalbital is combined with Lanicemine.
DB11957
The risk or severity of adverse effects can be increased when Butalbital is combined with Idalopirdine.
DB12071
The risk or severity of adverse effects can be increased when Butalbital is combined with Vabicaserin.
DB12093
The risk or severity of adverse effects can be increased when Butalbital is combined with Tetrahydropalmatine.
DB12105
The risk or severity of adverse effects can be increased when Butalbital is combined with Imagabalin.
DB12110
The risk or severity of adverse effects can be increased when Butalbital is combined with m-Chlorophenylpiperazine.
DB12111
The risk or severity of adverse effects can be increased when Butalbital is combined with MK-212.
DB12131
The risk or severity of adverse effects can be increased when Butalbital is combined with Vinpocetine.
DB12163
The risk or severity of adverse effects can be increased when Butalbital is combined with Sarpogrelate.
DB12177
The risk or severity of adverse effects can be increased when Butalbital is combined with Eplivanserin.
DB12184
The risk or severity of adverse effects can be increased when Butalbital is combined with Gepirone.
DB12229
The risk or severity of adverse effects can be increased when Butalbital is combined with Cerlapirdine.
DB12273
The risk or severity of adverse effects can be increased when Butalbital is combined with Ecopipam.
DB12308
The risk or severity of adverse effects can be increased when Butalbital is combined with Eltanolone.
DB12327
The risk or severity of adverse effects can be increased when Butalbital is combined with Salvinorin A.
DB12338
The risk or severity of adverse effects can be increased when Butalbital is combined with Carisbamate.
DB12361
The risk or severity of adverse effects can be increased when Butalbital is combined with Piclozotan.
DB12395
The risk or severity of adverse effects can be increased when Butalbital is combined with Esreboxetine.
DB12401
The risk or severity of adverse effects can be increased when Butalbital is combined with Bromperidol.
DB12427
The risk or severity of adverse effects can be increased when Butalbital is combined with Orvepitant.
DB12465
The risk or severity of adverse effects can be increased when Butalbital is combined with Ketanserin.
DB12518
The risk or severity of adverse effects can be increased when Butalbital is combined with Raclopride.
DB12537
The risk or severity of adverse effects can be increased when Butalbital is combined with Benzodiazepine.
DB12576
The risk or severity of adverse effects can be increased when Butalbital is combined with AZD-3043.
DB12590
The risk or severity of adverse effects can be increased when Butalbital is combined with Indiplon.
DB12661
The risk or severity of adverse effects can be increased when Butalbital is combined with Urapidil.
DB12710
The risk or severity of adverse effects can be increased when Butalbital is combined with Perazine.
DB12725
The risk or severity of adverse effects can be increased when Butalbital is combined with TD-8954.
DB12833
The risk or severity of adverse effects can be increased when Butalbital is combined with Tandospirone.
DB12867
The risk or severity of adverse effects can be increased when Butalbital is combined with Benperidol.
DB12883
The risk or severity of adverse effects can be increased when Butalbital is combined with Eltoprazine.
DB12951
The risk or severity of adverse effects can be increased when Butalbital is combined with Pivagabine.
DB12958
The risk or severity of adverse effects can be increased when Butalbital is combined with Prothipendyl.
DB12989
The risk or severity of adverse effects can be increased when Butalbital is combined with Neosaxitoxin.
DB13014
The risk or severity of adverse effects can be increased when Butalbital is combined with Hypericin.
DB13025
The risk or severity of adverse effects can be increased when Butalbital is combined with Tiapride.
DB13082
The risk or severity of adverse effects can be increased when Butalbital is combined with Nefiracetam.
DB13099
The risk or severity of adverse effects can be increased when Butalbital is combined with Valnoctamide.
DB13213
The risk or severity of adverse effects can be increased when Butalbital is combined with Butaperazine.
DB13219
The risk or severity of adverse effects can be increased when Butalbital is combined with Medifoxamine.
DB13221
The risk or severity of adverse effects can be increased when Butalbital is combined with Apronalide.
DB13234
The risk or severity of adverse effects can be increased when Butalbital is combined with Propanidid.
DB13253
The risk or severity of adverse effects can be increased when Butalbital is combined with Proxibarbal.
DB13256
The risk or severity of adverse effects can be increased when Butalbital is combined with Clothiapine.
DB13273
The risk or severity of adverse effects can be increased when Butalbital is combined with Sultopride.
DB13295
The risk or severity of adverse effects can be increased when Butalbital is combined with Atracurium.
DB13303
The risk or severity of adverse effects can be increased when Butalbital is combined with Febarbamate.
DB13323
The risk or severity of adverse effects can be increased when Butalbital is combined with Trichloroethylene.
DB13324
The risk or severity of adverse effects can be increased when Butalbital is combined with Tetrazepam.
DB13331
The risk or severity of adverse effects can be increased when Butalbital is combined with Pyrithyldione.
DB13335
The risk or severity of adverse effects can be increased when Butalbital is combined with Pinazepam.
DB13352
The risk or severity of adverse effects can be increased when Butalbital is combined with Deanol.
DB13354
The risk or severity of adverse effects can be increased when Butalbital is combined with Phenprobamate.
DB13357
The risk or severity of adverse effects can be increased when Butalbital is combined with Styramate.
DB13362
The risk or severity of adverse effects can be increased when Butalbital is combined with Pheneturide.
DB13370
The risk or severity of adverse effects can be increased when Butalbital is combined with Bromisoval.
DB13377
The risk or severity of adverse effects can be increased when Butalbital is combined with Vinbarbital.
DB13382
The risk or severity of adverse effects can be increased when Butalbital is combined with Chlorproethazine.
DB13396
The risk or severity of adverse effects can be increased when Butalbital is combined with Neocitrullamon.
DB13402
The risk or severity of adverse effects can be increased when Butalbital is combined with Acetylglycinamide chloral hydrate.
DB13403
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxypertine.
DB13414
The risk or severity of adverse effects can be increased when Butalbital is combined with Fenyramidol.
DB13420
The risk or severity of adverse effects can be increased when Butalbital is combined with Thiazinam.
DB13437
The risk or severity of adverse effects can be increased when Butalbital is combined with Medazepam.
DB13455
The risk or severity of adverse effects can be increased when Butalbital is combined with Phenibut.
DB13457
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxaflozane.
DB13505
The risk or severity of adverse effects can be increased when Butalbital is combined with Emepronium.
DB13520
The risk or severity of adverse effects can be increased when Butalbital is combined with Metergoline.
DB13522
The risk or severity of adverse effects can be increased when Butalbital is combined with Mebicar.
DB13523
The risk or severity of adverse effects can be increased when Butalbital is combined with Veralipride.
DB13534
The risk or severity of adverse effects can be increased when Butalbital is combined with Gedocarnil.
DB13541
The risk or severity of adverse effects can be increased when Butalbital is combined with Iprazochrome.
DB13550
The risk or severity of adverse effects can be increased when Butalbital is combined with Bifemelane.
DB13552
The risk or severity of adverse effects can be increased when Butalbital is combined with Trifluperidol.
DB13554
The risk or severity of adverse effects can be increased when Butalbital is combined with Moperone.
DB13557
The risk or severity of adverse effects can be increased when Butalbital is combined with Thiopropazate.
DB13572
The risk or severity of adverse effects can be increased when Butalbital is combined with Emylcamate.
DB13577
The risk or severity of adverse effects can be increased when Butalbital is combined with Allobarbital.
DB13584
The risk or severity of adverse effects can be increased when Butalbital is combined with Gallamine.
DB13588
The risk or severity of adverse effects can be increased when Butalbital is combined with Naftidrofuryl.
DB13598
The risk or severity of adverse effects can be increased when Butalbital is combined with Diethyl ether.
DB13601
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxiracetam.
DB13623
The risk or severity of adverse effects can be increased when Butalbital is combined with Fabomotizole.
DB13642
The risk or severity of adverse effects can be increased when Butalbital is combined with Pridinol.
DB13643
The risk or severity of adverse effects can be increased when Butalbital is combined with Loprazolam.
DB13648
The risk or severity of adverse effects can be increased when Butalbital is combined with Alcuronium.
DB13662
The risk or severity of adverse effects can be increased when Butalbital is combined with Hexapropymate.
DB13665
The risk or severity of adverse effects can be increased when Butalbital is combined with Fluanisone.
DB13676
The risk or severity of adverse effects can be increased when Butalbital is combined with Mosapramine.
DB13687
The risk or severity of adverse effects can be increased when Butalbital is combined with Niaprazine.
DB13690
The risk or severity of adverse effects can be increased when Butalbital is combined with Vinyl ether.
DB13733
The risk or severity of adverse effects can be increased when Butalbital is combined with Methylpentynol.
DB13737
The risk or severity of adverse effects can be increased when Butalbital is combined with Cyclobarbital.
DB13745
The risk or severity of adverse effects can be increased when Butalbital is combined with Fazadinium bromide.
DB13754
The risk or severity of adverse effects can be increased when Butalbital is combined with Mephenoxalone.
DB13770
The risk or severity of adverse effects can be increased when Butalbital is combined with Vinylbital.
DB13784
The risk or severity of adverse effects can be increased when Butalbital is combined with Dixyrazine.
DB13791
The risk or severity of adverse effects can be increased when Butalbital is combined with Penfluridol.
DB13799
The risk or severity of adverse effects can be increased when Butalbital is combined with Ethadione.
DB13805
The risk or severity of adverse effects can be increased when Butalbital is combined with Reposal.
DB13817
The risk or severity of adverse effects can be increased when Butalbital is combined with Carbromal.
DB13837
The risk or severity of adverse effects can be increased when Butalbital is combined with Doxefazepam.
DB13841
The risk or severity of adverse effects can be increased when Butalbital is combined with Clopenthixol.
DB13872
The risk or severity of adverse effects can be increased when Butalbital is combined with Lormetazepam.
DB13875
The risk or severity of adverse effects can be increased when Butalbital is combined with Harmaline.
DB13876
The risk or severity of adverse effects can be increased when Butalbital is combined with Brofaromine.
DB13940
The risk or severity of adverse effects can be increased when Butalbital is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
DB13948
The risk or severity of adverse effects can be increased when Butalbital is combined with N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine.
DB13984
The risk or severity of adverse effects can be increased when Butalbital is combined with Cyclopropane.
DB13993
The risk or severity of adverse effects can be increased when Butalbital is combined with MRK-409.
DB14010
The risk or severity of adverse effects can be increased when Butalbital is combined with 5-methoxy-N,N-dimethyltryptamine.
DB14028
The risk or severity of adverse effects can be increased when Butalbital is combined with Nordazepam.
DB14050
The risk or severity of adverse effects can be increased when Butalbital is combined with Cannabidivarin.
DB14509
The risk or severity of adverse effects can be increased when Butalbital is combined with Lithium carbonate.
DB14575
The risk or severity of adverse effects can be increased when Butalbital is combined with Eslicarbazepine.
DB14651
The risk or severity of adverse effects can be increased when Butalbital is combined with Perphenazine enanthate.
DB14672
The risk or severity of adverse effects can be increased when Butalbital is combined with Oxazepam acetate.
DB14715
The risk or severity of adverse effects can be increased when Butalbital is combined with Cinazepam.
DB14718
The risk or severity of adverse effects can be increased when Butalbital is combined with Pyrazolam.
DB14719
The risk or severity of adverse effects can be increased when Butalbital is combined with Bentazepam.
DB14754
The risk or severity of adverse effects can be increased when Butalbital is combined with Solriamfetol.
DB15203
The risk or severity of adverse effects can be increased when Butalbital is combined with JNJ-26489112.
DB00967
The risk or severity of adverse effects can be increased when Butalbital is combined with Desloratadine.
DB00726
The risk or severity of adverse effects can be increased when Butalbital is combined with Trimipramine.
DB00216
The risk or severity of adverse effects can be increased when Eletriptan is combined with Butalbital.
DB00247
The risk or severity of adverse effects can be increased when Butalbital is combined with Methysergide.
DB00404
The risk or severity of adverse effects can be increased when Butalbital is combined with Alprazolam.
DB00593
The risk or severity of adverse effects can be increased when Butalbital is combined with Ethosuximide.
DB00683
The risk or severity of adverse effects can be increased when Butalbital is combined with Midazolam.
DB00897
The risk or severity of adverse effects can be increased when Butalbital is combined with Triazolam.
DB01200
The risk or severity of adverse effects can be increased when Butalbital is combined with Bromocriptine.
DB08815
The risk or severity of adverse effects can be increased when Butalbital is combined with Lurasidone.
DB12404
The risk or severity of adverse effects can be increased when Butalbital is combined with Remimazolam.
DB00751
The risk or severity of adverse effects can be increased when Butalbital is combined with Epinastine.
DB00604
The risk or severity of adverse effects can be increased when Butalbital is combined with Cisapride.
DB01356
The risk or severity of adverse effects can be increased when Butalbital is combined with Lithium cation.
DB00230
The therapeutic efficacy of Butalbital can be increased when used in combination with Pregabalin.
DB09124
The serum concentration of Medrogestone can be decreased when it is combined with Butalbital.
DB04844
The risk or severity of sedation and somnolence can be increased when Butalbital is combined with Tetrabenazine.
DB12161
The risk or severity of sedation and somnolence can be increased when Butalbital is combined with Deutetrabenazine.
DB09532
The therapeutic efficacy of Secretin human can be decreased when used in combination with Butalbital.
DB04948
The therapeutic efficacy of Butalbital can be increased when used in combination with Lofexidine.
DB14583
The metabolism of Segesterone acetate can be increased when combined with Butalbital.
DB01174
The risk or severity of methemoglobinemia can be increased when Phenobarbital is combined with Butalbital.
DB01198
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Zopiclone.
DB00325
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Nitroprusside.
DB00435
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Nitric Oxide.
DB00727
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Nitroglycerin.
DB00883
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Isosorbide dinitrate.
DB01020
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Isosorbide mononitrate.
DB01612
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Amyl Nitrite.
DB00468
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Quinine.
DB06690
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Nitrous oxide.
DB00281
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Lidocaine.
DB00359
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Sulfadiazine.
DB00482
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Celecoxib.
DB00499
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Flutamide.
DB00608
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Chloroquine.
DB00698
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Nitrofurantoin.
DB00795
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Sulfasalazine.
DB00891
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Sulfapyridine.
DB01015
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Sulfamethoxazole.
DB01086
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Benzocaine.
DB01087
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Primaquine.
DB01435
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Antipyrine.
DB01438
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Phenazopyridine.
DB06706
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Isometheptene.
DB00252
The risk or severity of methemoglobinemia can be increased when Butalbital is combined with Phenytoin.
DB00581
The therapeutic efficacy of Lactulose can be decreased when used in combination with Butalbital.
DB01046
The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Butalbital.
DB01079
The therapeutic efficacy of Tegaserod can be decreased when used in combination with Butalbital.
DB01377
The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Butalbital.
DB01378
The therapeutic efficacy of Magnesium cation can be decreased when used in combination with Butalbital.
DB01593
The therapeutic efficacy of Zinc can be decreased when used in combination with Butalbital.
DB01638
The therapeutic efficacy of Sorbitol can be decreased when used in combination with Butalbital.
DB04816
The therapeutic efficacy of Dantron can be decreased when used in combination with Butalbital.
DB04823
The therapeutic efficacy of Oxyphenisatin can be decreased when used in combination with Butalbital.
DB04824
The therapeutic efficacy of Phenolphthalein can be decreased when used in combination with Butalbital.
DB07715
The therapeutic efficacy of Emodin can be decreased when used in combination with Butalbital.
DB08890
The therapeutic efficacy of Linaclotide can be decreased when used in combination with Butalbital.
DB09020
The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Butalbital.
DB09104
The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Butalbital.
DB09219
The therapeutic efficacy of Bisoxatin can be decreased when used in combination with Butalbital.
DB09268
The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Butalbital.
DB09281
The therapeutic efficacy of Magnesium trisilicate can be decreased when used in combination with Butalbital.
DB09287
The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Butalbital.
DB09311
The therapeutic efficacy of Polycarbophil can be decreased when used in combination with Butalbital.
DB09413
The therapeutic efficacy of Monopotassium phosphate can be decreased when used in combination with Butalbital.
DB09414
The therapeutic efficacy of Dipotassium phosphate can be decreased when used in combination with Butalbital.
DB09462
The therapeutic efficacy of Glycerin can be decreased when used in combination with Butalbital.
DB09472
The therapeutic efficacy of Sodium sulfate can be decreased when used in combination with Butalbital.
DB09481
The therapeutic efficacy of Magnesium carbonate can be decreased when used in combination with Butalbital.
DB09484
The therapeutic efficacy of Sodium fluorophosphate can be decreased when used in combination with Butalbital.
DB11057
The therapeutic efficacy of Mineral oil can be decreased when used in combination with Butalbital.
DB11059
The therapeutic efficacy of Carboxymethylcellulose can be decreased when used in combination with Butalbital.
DB11089
The therapeutic efficacy of Docusate can be decreased when used in combination with Butalbital.
DB11097
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Butalbital.
DB11110
The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Butalbital.
DB11113
The therapeutic efficacy of Castor oil can be decreased when used in combination with Butalbital.
DB11189
The therapeutic efficacy of Magnesium glycinate can be decreased when used in combination with Butalbital.
DB11228
The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Butalbital.
DB11365
The therapeutic efficacy of Sennosides can be decreased when used in combination with Butalbital.
DB12942
The therapeutic efficacy of Lactitol can be decreased when used in combination with Butalbital.
DB13170
The therapeutic efficacy of Plecanatide can be decreased when used in combination with Butalbital.
DB13486
The therapeutic efficacy of Magnesium peroxide can be decreased when used in combination with Butalbital.
DB13526
The therapeutic efficacy of Pentaerithrityl can be decreased when used in combination with Butalbital.
DB13707
The therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Butalbital.
DB14232
The therapeutic efficacy of Deacetylbisacodyl can be decreased when used in combination with Butalbital.
DB14482
The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Butalbital.
DB14499
The therapeutic efficacy of Potassium sulfate can be decreased when used in combination with Butalbital.
DB14502
The therapeutic efficacy of Sodium phosphate, dibasic can be decreased when used in combination with Butalbital.
DB14503
The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Butalbital.
DB14504
The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Butalbital.
DB14513
The therapeutic efficacy of Magnesium can be decreased when used in combination with Butalbital.
DB14585
The therapeutic efficacy of Plantago ovata seed can be decreased when used in combination with Butalbital.
DB14627
The therapeutic efficacy of Oxyphenisatin acetate can be decreased when used in combination with Butalbital.
DB14684
The therapeutic efficacy of Calcium polycarbophil can be decreased when used in combination with Butalbital.
DB14963
The therapeutic efficacy of Konjac mannan can be decreased when used in combination with Butalbital.
DB15477
The therapeutic efficacy of Alloin can be decreased when used in combination with Butalbital.
DB15478
The therapeutic efficacy of Frangula purshiana bark can be decreased when used in combination with Butalbital.
DB11622
The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Butalbital.
DB14516
The therapeutic efficacy of Sodium cation can be decreased when used in combination with Butalbital.
DB14546
The therapeutic efficacy of Sulfate ion can be decreased when used in combination with Butalbital.
DB00191
The metabolism of Phentermine can be increased when combined with Butalbital.
DB00207
The metabolism of Azithromycin can be increased when combined with Butalbital.
DB00208
The metabolism of Ticlopidine can be increased when combined with Butalbital.
DB00426
The metabolism of Famciclovir can be increased when combined with Butalbital.
DB00518
The metabolism of Albendazole can be increased when combined with Butalbital.
DB00567
The metabolism of Cephalexin can be increased when combined with Butalbital.
DB01039
The metabolism of Fenofibrate can be increased when combined with Butalbital.
DB01072
The metabolism of Atazanavir can be increased when combined with Butalbital.
DB01098
The metabolism of Rosuvastatin can be increased when combined with Butalbital.
DB01411
The metabolism of Pranlukast can be increased when combined with Butalbital.
DB01431
The metabolism of Allylestrenol can be increased when combined with Butalbital.
DB01656
The metabolism of Roflumilast can be increased when combined with Butalbital.
DB06480
The metabolism of Prucalopride can be increased when combined with Butalbital.
DB08882
The metabolism of Linagliptin can be increased when combined with Butalbital.
DB09030
The metabolism of Vorapaxar can be increased when combined with Butalbital.
DB09048
The metabolism of Netupitant can be increased when combined with Butalbital.
DB09079
The metabolism of Nintedanib can be increased when combined with Butalbital.
DB09299
The metabolism of Tenofovir alafenamide can be increased when combined with Butalbital.
DB11094
The metabolism of Vitamin D can be increased when combined with Butalbital.
DB11273
The metabolism of Dihydroergocornine can be increased when combined with Butalbital.
DB11730
The metabolism of Ribociclib can be increased when combined with Butalbital.
DB11952
The metabolism of Duvelisib can be increased when combined with Butalbital.
DB12141
The metabolism of Gilteritinib can be increased when combined with Butalbital.
DB12515
The metabolism of 9-aminocamptothecin can be increased when combined with Butalbital.
DB12952
The metabolism of Methylprednisone can be increased when combined with Butalbital.
DB13345
The metabolism of Dihydroergocristine can be increased when combined with Butalbital.
DB13385
The metabolism of Dihydroergocryptine can be increased when combined with Butalbital.
DB14009
The metabolism of Medical Cannabis can be increased when combined with Butalbital.
DB14126
The metabolism of Tenofovir can be increased when combined with Butalbital.
DB00549
The metabolism of Zafirlukast can be increased when combined with Butalbital.
DB15444
The metabolism of Elexacaftor can be increased when combined with Butalbital.
DB12887
The metabolism of Tazemetostat can be increased when combined with Butalbital.
DB06717
The metabolism of Fosaprepitant can be increased when combined with Butalbital.
DB12825
The metabolism of Lefamulin can be increased when combined with Butalbital.
DB11742
The metabolism of Ebastine can be increased when combined with Butalbital.
DB11633
The metabolism of Isavuconazole can be increased when combined with Butalbital.
DB04572
The metabolism of Butalbital can be increased when combined with Thiotepa.
DB00188
The metabolism of Bortezomib can be increased when combined with Butalbital.
DB00248
The metabolism of Cabergoline can be increased when combined with Butalbital.
DB08910
The metabolism of Pomalidomide can be increased when combined with Butalbital.
DB00531
The metabolism of Cyclophosphamide can be increased when combined with Butalbital.
DB00204
The metabolism of Dofetilide can be increased when combined with Butalbital.
DB00277
The metabolism of Theophylline can be increased when combined with Butalbital.
DB00864
The metabolism of Tacrolimus can be increased when combined with Butalbital.
DB00877
The metabolism of Sirolimus can be increased when combined with Butalbital.
DB00908
The metabolism of Quinidine can be increased when combined with Butalbital.
DB00946
The metabolism of Phenprocoumon can be increased when combined with Butalbital.
DB01008
The metabolism of Busulfan can be increased when combined with Butalbital.
DB01100
The metabolism of Pimozide can be increased when combined with Butalbital.
DB01118
The metabolism of Amiodarone can be increased when combined with Butalbital.
DB01229
The metabolism of Paclitaxel can be increased when combined with Butalbital.
DB01254
The metabolism of Dasatinib can be increased when combined with Butalbital.
DB01320
The metabolism of Fosphenytoin can be increased when combined with Butalbital.
DB01396
The metabolism of Digitoxin can be increased when combined with Butalbital.
DB01590
The metabolism of Everolimus can be increased when combined with Butalbital.
DB04855
The metabolism of Dronedarone can be increased when combined with Butalbital.
DB06287
The metabolism of Temsirolimus can be increased when combined with Butalbital.
DB09289
The metabolism of Tianeptine can be increased when combined with Butalbital.
DB05239
The metabolism of Cobimetinib can be increased when combined with Butalbital.
DB09054
The metabolism of Idelalisib can be increased when combined with Butalbital.
DB09063
The metabolism of Ceritinib can be increased when combined with Butalbital.
DB09330
The metabolism of Osimertinib can be increased when combined with Butalbital.
DB11963
The metabolism of Dacomitinib can be increased when combined with Butalbital.
DB12015
The metabolism of Alpelisib can be increased when combined with Butalbital.
DB00540
The metabolism of Nortriptyline can be increased when combined with Butalbital.
DB00320
The metabolism of Dihydroergotamine can be increased when combined with Butalbital.
DB00696
The metabolism of Ergotamine can be increased when combined with Butalbital.
DB01242
The metabolism of Clomipramine can be increased when combined with Butalbital.
DB00872
The metabolism of Conivaptan can be increased when combined with Butalbital.
DB00637
The metabolism of Astemizole can be increased when combined with Butalbital.
DB08827
The metabolism of Lomitapide can be increased when combined with Butalbital.
DB12371
The metabolism of Siponimod can be increased when combined with Butalbital.
DB00563
The metabolism of Methotrexate can be increased when combined with Butalbital.
DB00361
The metabolism of Vinorelbine can be increased when combined with Butalbital.
DB00541
The metabolism of Vincristine can be increased when combined with Butalbital.
DB00570
The metabolism of Vinblastine can be increased when combined with Butalbital.
DB00997
The metabolism of Doxorubicin can be increased when combined with Butalbital.
DB01248
The metabolism of Docetaxel can be increased when combined with Butalbital.
DB05109
The metabolism of Trabectedin can be increased when combined with Butalbital.
DB05294
The metabolism of Vandetanib can be increased when combined with Butalbital.
DB08881
The metabolism of Vemurafenib can be increased when combined with Butalbital.
DB11363
The metabolism of Alectinib can be increased when combined with Butalbital.
DB11581
The metabolism of Venetoclax can be increased when combined with Butalbital.
DB11641
The metabolism of Vinflunine can be increased when combined with Butalbital.
DB11703
The metabolism of Acalabrutinib can be increased when combined with Butalbital.
DB13874
The metabolism of Enasidenib can be increased when combined with Butalbital.
DB15035
The metabolism of Zanubrutinib can be increased when combined with Butalbital.
DB00309
The metabolism of Vindesine can be increased when combined with Butalbital.
DB00398
The metabolism of Sorafenib can be increased when combined with Butalbital.
DB00675
The metabolism of Tamoxifen can be increased when combined with Butalbital.
DB00773
The metabolism of Etoposide can be increased when combined with Butalbital.
DB01268
The metabolism of Sunitinib can be increased when combined with Butalbital.
DB04845
The metabolism of Ixabepilone can be increased when combined with Butalbital.
DB04868
The metabolism of Nilotinib can be increased when combined with Butalbital.
DB06589
The metabolism of Pazopanib can be increased when combined with Butalbital.
DB06595
The metabolism of Midostaurin can be increased when combined with Butalbital.
DB06603
The metabolism of Panobinostat can be increased when combined with Butalbital.
DB06616
The metabolism of Bosutinib can be increased when combined with Butalbital.
DB06626
The metabolism of Axitinib can be increased when combined with Butalbital.
DB08865
The metabolism of Crizotinib can be increased when combined with Butalbital.
DB08870
The metabolism of Brentuximab vedotin can be increased when combined with Butalbital.
DB08877
The metabolism of Ruxolitinib can be increased when combined with Butalbital.
DB08901
The metabolism of Ponatinib can be increased when combined with Butalbital.
DB08912
The metabolism of Dabrafenib can be increased when combined with Butalbital.
DB09073
The metabolism of Palbociclib can be increased when combined with Butalbital.
DB09143
The metabolism of Sonidegib can be increased when combined with Butalbital.
DB09570
The metabolism of Ixazomib can be increased when combined with Butalbital.
DB11828
The metabolism of Neratinib can be increased when combined with Butalbital.
DB12147
The metabolism of Erdafitinib can be increased when combined with Butalbital.
DB12267
The metabolism of Brigatinib can be increased when combined with Butalbital.
DB12483
The metabolism of Copanlisib can be increased when combined with Butalbital.
DB12978
The metabolism of Pexidartinib can be increased when combined with Butalbital.
DB14568
The metabolism of Ivosidenib can be increased when combined with Butalbital.
DB00762
The metabolism of Irinotecan can be increased when combined with Butalbital.
DB06176
The metabolism of Romidepsin can be increased when combined with Butalbital.
DB06212
The metabolism of Tolvaptan can be increased when combined with Butalbital.
DB08896
The metabolism of Regorafenib can be increased when combined with Butalbital.
DB09074
The metabolism of Olaparib can be increased when combined with Butalbital.
DB11817
The metabolism of Baricitinib can be increased when combined with Butalbital.
DB12001
The metabolism of Abemaciclib can be increased when combined with Butalbital.
DB01128
The metabolism of Bicalutamide can be increased when combined with Butalbital.
DB05773
The metabolism of Trastuzumab emtansine can be increased when combined with Butalbital.
DB06772
The metabolism of Cabazitaxel can be increased when combined with Butalbital.
DB04896
The metabolism of Milnacipran can be increased when combined with Butalbital.
DB08918
The metabolism of Levomilnacipran can be increased when combined with Butalbital.
DB01256
The metabolism of Retapamulin can be increased when combined with Butalbital.
DB05077
The risk or severity of adverse effects can be increased when SLV319 is combined with Butalbital.
DB06155
The risk or severity of adverse effects can be increased when Rimonabant is combined with Butalbital.
DB06624
The risk or severity of adverse effects can be increased when Taranabant is combined with Butalbital.
DB09061
The risk or severity of adverse effects can be increased when Cannabidiol is combined with Butalbital.
DB11903
The risk or severity of adverse effects can be increased when GW842166 is combined with Butalbital.
DB12193
The risk or severity of adverse effects can be increased when Ajulemic acid is combined with Butalbital.
DB12649
The risk or severity of adverse effects can be increased when Ibipinabant is combined with Butalbital.
DB13070
The risk or severity of adverse effects can be increased when Surinabant is combined with Butalbital.
DB13950
The risk or severity of adverse effects can be increased when WIN 55212-2 is combined with Butalbital.
DB14011
The risk or severity of adverse effects can be increased when Nabiximols is combined with Butalbital.
DB14043
The risk or severity of adverse effects can be increased when Palmidrol is combined with Butalbital.
DB14737
The risk or severity of adverse effects can be increased when Cannabinol is combined with Butalbital.
DB00291
The therapeutic efficacy of Butalbital can be decreased when used in combination with Chlorambucil.
DB00397
The therapeutic efficacy of Butalbital can be decreased when used in combination with Phenylpropanolamine.
DB00422
The therapeutic efficacy of Butalbital can be decreased when used in combination with Methylphenidate.
DB00456
The therapeutic efficacy of Butalbital can be decreased when used in combination with Cefalotin.
DB00493
The therapeutic efficacy of Butalbital can be decreased when used in combination with Cefotaxime.
DB00719
The therapeutic efficacy of Butalbital can be decreased when used in combination with Azatadine.
DB00779
The therapeutic efficacy of Butalbital can be decreased when used in combination with Nalidixic acid.
DB00902
The therapeutic efficacy of Butalbital can be decreased when used in combination with Methdilazine.
DB00916
The therapeutic efficacy of Butalbital can be decreased when used in combination with Metronidazole.
DB00951
The therapeutic efficacy of Butalbital can be decreased when used in combination with Isoniazid.
DB01004
The therapeutic efficacy of Butalbital can be decreased when used in combination with Ganciclovir.
DB01061
The therapeutic efficacy of Butalbital can be decreased when used in combination with Azlocillin.
DB01598
The therapeutic efficacy of Butalbital can be decreased when used in combination with Imipenem.
DB01610
The therapeutic efficacy of Butalbital can be decreased when used in combination with Valganciclovir.
DB02136
The therapeutic efficacy of Butalbital can be decreased when used in combination with Cephalosporin analog.
DB03313
The therapeutic efficacy of Butalbital can be decreased when used in combination with Cephalosporin C.
DB03938
The therapeutic efficacy of Butalbital can be decreased when used in combination with Deacetoxycephalosporin C.
DB06793
The therapeutic efficacy of Butalbital can be decreased when used in combination with Levopropoxyphene.
DB09449
The therapeutic efficacy of Butalbital can be decreased when used in combination with Sodium phosphate, monobasic.
DB11199
The therapeutic efficacy of Butalbital can be decreased when used in combination with Sage oil.
DB11238
The therapeutic efficacy of Butalbital can be decreased when used in combination with Borage oil.
DB11358
The therapeutic efficacy of Butalbital can be decreased when used in combination with Evening primrose oil.
DB11447
The therapeutic efficacy of Butalbital can be decreased when used in combination with Phenothiazine.
DB13679
The therapeutic efficacy of Butalbital can be decreased when used in combination with Dexchlorpheniramine.
DB13854
The therapeutic efficacy of Butalbital can be decreased when used in combination with Gamolenic acid.
DB14071
The therapeutic efficacy of Butalbital can be decreased when used in combination with Desmethylsertraline.
DB01362
The therapeutic efficacy of Butalbital can be decreased when used in combination with Iohexol.
DB00822
The therapeutic efficacy of Butalbital can be decreased when used in combination with Disulfiram.
DB01218
The therapeutic efficacy of Butalbital can be decreased when used in combination with Halofantrine.
DB09555
The therapeutic efficacy of Butalbital can be decreased when used in combination with Dexchlorpheniramine maleate.
DB14256
The therapeutic efficacy of Butalbital can be decreased when used in combination with Centella asiatica.
DB00455
Butalbital may increase the anticholinergic activities of Loratadine.
DB14507
The therapeutic efficacy of Butalbital can be increased when used in combination with Lithium citrate.
DB14506
The therapeutic efficacy of Butalbital can be increased when used in combination with Lithium hydroxide.
DB09272
The risk or severity of constipation can be increased when Butalbital is combined with Eluxadoline.
DB00381
The metabolism of Amlodipine can be increased when combined with Butalbital.
DB01068
The metabolism of Clonazepam can be increased when combined with Butalbital.
DB11823
The risk or severity of adverse effects can be increased when Butalbital is combined with Esketamine.
DB00395
The risk or severity of adverse effects can be increased when Carisoprodol is combined with Butalbital.
DB06711
The risk or severity of CNS depression can be increased when Naphazoline is combined with Butalbital.
DB08907
The serum concentration of Canagliflozin can be decreased when it is combined with Butalbital.
DB00402
The risk or severity of CNS depression can be increased when Butalbital is combined with Eszopiclone.
DB00564
Carbamazepine may increase the Change in thyroid function activities of Butalbital.
DB00575
The risk or severity of sedation can be increased when Clonidine is combined with Butalbital.
DB00843
The therapeutic efficacy of Butalbital can be decreased when used in combination with Donepezil.
DB11986
The metabolism of Entrectinib can be increased when combined with Butalbital.
DB00255
The metabolism of Diethylstilbestrol can be increased when combined with Butalbital.
DB00783
The metabolism of Estradiol can be increased when combined with Butalbital.
DB00977
The metabolism of Ethinylestradiol can be increased when combined with Butalbital.
DB01357
The metabolism of Mestranol can be increased when combined with Butalbital.
DB13954
The metabolism of Estradiol cypionate can be increased when combined with Butalbital.
DB13956
The metabolism of Estradiol valerate can be increased when combined with Butalbital.
DB00294
The metabolism of Etonogestrel can be increased when combined with Butalbital.
DB00304
The metabolism of Desogestrel can be increased when combined with Butalbital.
DB00351
The metabolism of Megestrol acetate can be increased when combined with Butalbital.
DB00367
The metabolism of Levonorgestrel can be increased when combined with Butalbital.
DB00396
The metabolism of Progesterone can be increased when combined with Butalbital.
DB00603
The metabolism of Medroxyprogesterone acetate can be increased when combined with Butalbital.
DB00717
The metabolism of Norethisterone can be increased when combined with Butalbital.
DB00823
The metabolism of Ethynodiol diacetate can be increased when combined with Butalbital.
DB00834
The metabolism of Mifepristone can be increased when combined with Butalbital.
DB00957
The metabolism of Norgestimate can be increased when combined with Butalbital.
DB01395
The metabolism of Drospirenone can be increased when combined with Butalbital.
DB04066
The metabolism of p-Coumaric acid can be increased when combined with Butalbital.
DB04574
The metabolism of Estrone sulfate can be increased when combined with Butalbital.
DB04682
The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Butalbital.
DB04839
The metabolism of Cyproterone acetate can be increased when combined with Butalbital.
DB05830
The metabolism of Trestolone can be increased when combined with Butalbital.
DB06266
The metabolism of Lonidamine can be increased when combined with Butalbital.
DB06713
The metabolism of Norelgestromin can be increased when combined with Butalbital.
DB06730
The metabolism of Gestodene can be increased when combined with Butalbital.
DB06789
The metabolism of Hydroxyprogesterone caproate can be increased when combined with Butalbital.
DB09123
The metabolism of Dienogest can be increased when combined with Butalbital.
DB09371
The metabolism of Norethynodrel can be increased when combined with Butalbital.
DB09389
The metabolism of Norgestrel can be increased when combined with Butalbital.
DB09401
The metabolism of Isosorbide can be increased when combined with Butalbital.
DB11507
The metabolism of Cloprostenol can be increased when combined with Butalbital.
DB11619
The metabolism of Gestrinone can be increased when combined with Butalbital.
DB11636
The metabolism of Nomegestrol can be increased when combined with Butalbital.
DB12025
The metabolism of Triptolide can be increased when combined with Butalbital.
DB12474
The metabolism of Lynestrenol can be increased when combined with Butalbital.
DB13044
The metabolism of Gossypol can be increased when combined with Butalbital.
DB13310
The metabolism of Ormeloxifene can be increased when combined with Butalbital.
DB13528
The metabolism of Chlormadinone can be increased when combined with Butalbital.
DB13563
The metabolism of Norgestrienone can be increased when combined with Butalbital.
DB13685
The metabolism of Quingestanol can be increased when combined with Butalbital.
DB13857
The metabolism of Demegestone can be increased when combined with Butalbital.
DB13866
The metabolism of Etynodiol can be increased when combined with Butalbital.
DB13944
The metabolism of Testosterone enanthate can be increased when combined with Butalbital.
DB13953
The metabolism of Estradiol benzoate can be increased when combined with Butalbital.
DB13981
The metabolism of Nomegestrol acetate can be increased when combined with Butalbital.
DB14678
The metabolism of Norethindrone enanthate can be increased when combined with Butalbital.
DB06804
The metabolism of Nonoxynol-9 can be increased when combined with Butalbital.
DB01611
The therapeutic efficacy of Hydroxychloroquine can be decreased when used in combination with Butalbital.
DB00924
The risk or severity of CNS depression can be increased when Butalbital is combined with Cyclobenzaprine.
DB01233
The risk or severity of sedation can be increased when Metoclopramide is combined with Butalbital.
DB11732
The risk or severity of adverse effects can be increased when Butalbital is combined with Lasmiditan.
DB11951
The serum concentration of Lemborexant can be decreased when it is combined with Butalbital.
DB06077
The serum concentration of Lumateperone can be decreased when it is combined with Butalbital.
DB00243
The metabolism of Ranolazine can be increased when combined with Butalbital.
DB00193
The metabolism of Tramadol can be increased when combined with Butalbital.
DB01190
The metabolism of Clindamycin can be increased when combined with Butalbital.
DB00246
The risk or severity of adverse effects can be increased when Butalbital is combined with Ziprasidone.
DB12457
The metabolism of Rimegepant can be increased when combined with Butalbital.
DB00502
The risk or severity of CNS depression can be increased when Butalbital is combined with Haloperidol.
DB11791
The serum concentration of Capmatinib can be decreased when it is combined with Butalbital.
DB15685
The serum concentration of Selpercatinib can be decreased when it is combined with Butalbital.
DB06283
The risk or severity of CNS depression can be increased when Butalbital is combined with Ziconotide.
DB00256
The metabolism of Lymecycline can be increased when combined with Butalbital.
DB00472
Butalbital may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
DB14881
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Butalbital is combined with Oliceridine.
序列
实验性质
Water Solubility
1700 mg/L (at 25 °C)
Barceloux, Donald G. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Hoboken, N.J: John Wiley & Sons, 2012. Internet resource.
Melting Point
138.5
Barceloux, Donald G. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Hoboken, N.J: John Wiley & Sons, 2012. Internet resource.
logP
1.87
Barceloux, Donald G. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Hoboken, N.J: John Wiley & Sons, 2012. Internet resource.
外部标识符
resource:Drugs Product Database (DPD)
identifier:8231
resource:ChEBI
identifier:102524
resource:PubChem Compound
identifier:2481
resource:PubChem Substance
identifier:46505876
resource:KEGG Drug
identifier:D03182
resource:ChemSpider
identifier:2387
resource:PharmGKB
identifier:PA448695
resource:Therapeutic Targets Database
identifier:DAP000668
resource:Wikipedia
identifier:Butalbital
resource:ChEMBL
identifier:CHEMBL454
resource:ZINC
identifier:ZINC000003830347
resource:RxCUI
identifier:19860
外部链接
RxList
http://www.rxlist.com/cgi/generic/esgic.htm
路径
目标
id:BE0000795
name:Gamma-aminobutyric acid receptor subunit alpha-1
organism:Humans
action:potentiator
Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57.
Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217.
Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303.
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Cutrer FM, Mitsikostas DD, Ayata G, Sanchez del Rio M: Attenuation by butalbital of capsaicin-induced c-fos-like immunoreactivity in trigeminal nucleus caudalis. Headache. 1999 Nov-Dec;39(10):697-704.
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-1
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
gene-name:GABRA1
locus:5q34-q35
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 422-443
signal-regions:1-27
theoretical-pi:9.61
molecular-weight:51801.395
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4075GenAtlasGABRA1GenBank Gene DatabaseX13584GenBank Protein Database31631IUPHAR404Guide to Pharmacology404UniProtKBP14867UniProt AccessionGBRA1_HUMAN
synonyms:GABA(A) receptor subunit alpha-1
amino-acid-sequence:>lcl|BSEQ0010561|Gamma-aminobutyric acid receptor subunit alpha-1 MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
gene-sequence:>lcl|BSEQ0010562|Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) ATGAGGAAAAGTCCAGGTCTGTCTGACTGTCTTTGGGCCTGGATCCTCCTTCTGAGCACA CTGACTGGAAGAAGCTATGGACAGCCGTCATTACAAGATGAACTTAAAGACAATACCACT GTCTTCACCAGGATTTTGGACAGACTCCTAGATGGTTATGACAATCGCCTGAGACCAGGA TTGGGAGAGCGTGTAACCGAAGTGAAGACTGATATCTTCGTCACCAGTTTCGGACCCGTT TCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAA AGGTTAAAATTTAAAGGACCTATGACAGTCCTCCGGTTAAATAACCTAATGGCAAGTAAA ATCTGGACTCCGGACACATTTTTCCACAATGGAAAGAAGTCAGTGGCCCACAACATGACC ATGCCCAACAAACTCCTGCGGATCACAGAGGATGGCACCTTGCTGTACACCATGAGGCTG ACAGTGAGAGCTGAATGTCCGATGCATTTGGAGGACTTCCCTATGGATGCCCATGCTTGC CCACTAAAATTTGGAAGTTATGCTTATACAAGAGCAGAAGTTGTTTATGAATGGACCAGA GAGCCAGCACGCTCAGTGGTTGTAGCAGAAGATGGATCACGTCTAAACCAGTATGACCTT CTTGGACAAACAGTAGACTCTGGAATTGTCCAGTCAAGTACAGGAGAATATGTTGTTATG ACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCA TGCATAATGACAGTGATTCTCTCACAAGTCTCCTTCTGGCTCAACAGAGAGTCTGTACCA GCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACATTGAGCATCAGTGCC AGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCCGTGTGC TATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACTAAGAGA GGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCT CTTATTAAGAAAAACAACACTTACGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCC AGGGGCGACCCGGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCTAAAGAGGTC AAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGAC CGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCT ACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA receptor complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctiondrug bindingfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
id:BE0000381
name:Gamma-aminobutyric acid receptor subunit alpha-2
organism:Humans
action:potentiator
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217.
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA2
locus:4p12
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 420-441
signal-regions:1-28
theoretical-pi:9.41
molecular-weight:51325.85
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4076GenAtlasGABRA2GenBank Gene DatabaseS62907GenBank Protein Database386422IUPHAR405Guide to Pharmacology405UniProtKBP47869UniProt AccessionGBRA2_HUMAN
synonyms:GABA(A) receptor subunit alpha-2
amino-acid-sequence:>lcl|BSEQ0037005|Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
gene-sequence:>lcl|BSEQ0010268|Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) ATGAAGACAAAATTGAACATCTACAACATGCAGTTCCTGCTTTTTGTTTTCTTGGTGTGG GACCCTGCCAGGTTGGTGCTGGCTAACATCCAAGAAGATGAGGCTAAAAATAACATTACC ATCTTTACGAGAATTCTTGACAGACTTCTGGATGGTTACGATAATCGGCTTAGACCAGGA CTGGGAGACAGTATTACTGAAGTCTTCACTAACATCTACGTGACCAGTTTTGGCCCTGTC TCAGATACAGATATGGAATATACAATTGATGTTTTCTTTCGACAAAAATGGAAAGATGAA CGTTTAAAATTTAAAGGTCCTATGAATATCCTTCGACTAAACAATTTAATGGCTAGCAAA ATCTGGACTCCAGATACCTTTTTTCACAATGGGAAAAAATCAGTAGCTCATAATATGACA ATGCCAAATAAGTTGCTTCGAATTCAGGATGATGGGACTCTGCTGTATACCATGAGGCTT ACAGTTCAAGCTGAATGCCCAATGCACTTGGAGGATTTCCCAATGGATGCTCATTCATGT CCTCTGAAATTTGGCAGCTATGCATATACAACTTCAGAGGTCACTTATATTTGGACTTAC AATGCATCTGATTCAGTACAGGTTGCTCCTGATGGCTCTAGGTTAAATCAATATGACCTG CTGGGCCAATCAATCGGAAAGGAGACAATTAAATCCAGTACAGGTGAATATACTGTAATG ACAGCTCATTTCCACCTGAAAAGAAAAATTGGGTATTTTGTGATTCAAACCTATCTGCCT TGCATCATGACTGTCATTCTCTCCCAAGTTTCATTCTGGCTTAACAGAGAATCTGTGCCT GCAAGAACTGTGTTTGGAGTAACAACTGTCCTAACAATGACAACTCTAAGCATCAGTGCT CGGAATTCTCTCCCCAAAGTGGCTTATGCAACTGCCATGGACTGGTTTATTGCTGTTTGT TATGCATTTGTGTTCTCTGCCCTAATTGAATTTGCAACTGTTAATTACTTCACCAAAAGA GGATGGGCTTGGGATGGGAAGAGTGTAGTAAATGACAAGAAAAAAGAAAAGGCTTCCGTT ATGATACAGAACAACGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAA GATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGAAGCCA GAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATG TCCAGAATAGTTTTTCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATAT TTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentaxoncomponentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentintegral component of synaptic vesicle membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessneurotransmitter transportprocessregulation of membrane potentialprocessregulation of neurotransmitter levelsprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transport
id:BE0000523
name:Gamma-aminobutyric acid receptor subunit alpha-3
organism:Humans
action:potentiator
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217.
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-3
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA3
locus:Xq28
cellular-location:Cell junction
transmembrane-regions:277-298 304-325 338-359 458-479
signal-regions:1-28
theoretical-pi:8.93
molecular-weight:55164.055
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4077GenAtlasGABRA3GenBank Gene DatabaseS62908GenBank Protein Database386424IUPHAR406Guide to Pharmacology406UniProtKBP34903UniProt AccessionGBRA3_HUMAN
synonyms:GABA(A) receptor subunit alpha-3
amino-acid-sequence:>lcl|BSEQ0016119|Gamma-aminobutyric acid receptor subunit alpha-3 MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRL NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN YFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN RESAIKGMIRKQ
gene-sequence:>lcl|BSEQ0016120|Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3) ATGATAATCACACAAACAAGTCACTGTTACATGACCAGCCTTGGGATTCTTTTCCTGATT AATATTCTCCCTGGAACCACTGGTCAAGGGGAATCAAGACGACAAGAACCCGGGGACTTT GTGAAGCAGGACATTGGCGGGCTGTCTCCTAAGCATGCCCCAGATATTCCTGATGACAGC ACTGACAACATCACTATCTTCACCAGAATCTTGGATCGTCTTCTGGACGGCTATGACAAC CGGCTGCGACCTGGGCTTGGAGATGCAGTGACTGAAGTGAAGACTGACATCTACGTGACC AGTTTTGGCCCTGTGTCAGACACTGACATGGAGTACACTATTGATGTATTTTTTCGGCAG ACATGGCATGATGAAAGACTGAAATTTGATGGCCCCATGAAGATCCTTCCACTGAACAAT CTCCTGGCTAGTAAGATCTGGACACCGGACACCTTCTTCCACAATGGCAAGAAATCAGTG GCTCATAACATGACCACGCCCAACAAGCTGCTCAGATTGGTGGACAACGGAACCCTCCTC TATACAATGAGGTTAACAATTCATGCTGAGTGTCCCATGCATTTGGAAGATTTTCCCATG GATGTGCATGCCTGCCCACTGAAGTTTGGAAGCTATGCCTATACAACAGCTGAAGTGGTT TATTCTTGGACTCTCGGAAAGAACAAATCCGTGGAAGTGGCACAGGATGGTTCTCGCTTG AACCAGTATGACCTTTTGGGCCATGTTGTTGGGACAGAGATAATCCGGTCTAGTACAGGA GAATATGTCGTCATGACAACCCACTTCCATCTCAAGCGAAAAATTGGCTACTTTGTGATC CAGACCTACTTGCCATGTATCATGACTGTCATTCTGTCACAAGTGTCGTTCTGGCTCAAC AGAGAGTCTGTTCCTGCCCGTACAGTCTTTGGTGTCACCACTGTGCTTACCATGACCACC TTGAGTATCAGTGCCAGAAATTCCTTACCTAAAGTGGCATATGCGACGGCCATGGACTGG TTCATAGCCGTCTGTTATGCCTTTGTATTTTCTGCACTGATTGAATTTGCCACTGTCAAC TATTTCACCAAGCGGAGTTGGGCTTGGGAAGGCAAGAAGGTGCCAGAGGCCCTGGAGATG AAGAAGAAAACACCAGCAGCCCCAGCAAAGAAAACCAGCACTACCTTCAACATCGTGGGG ACCACCTATCCCATCAACCTGGCCAAGGACACTGAATTTTCCACCATCTCCAAGGGCGCT GCTCCCAGTGCCTCCTCAACCCCAACAATCATTGCTTCACCCAAGGCCACCTACGTGCAG GACAGCCCGACTGAGACCAAGACCTACAACAGTGTCAGCAAGGTTGACAAAATTTCCCGC ATCATCTTTCCTGTGCTCTTTGCCATATTCAATCTGGTCTATTGGGCCACATATGTCAAC CGGGAGTCAGCTATCAAGGGCATGATCCGCAAACAGTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
id:BE0000478
name:Gamma-aminobutyric acid receptor subunit alpha-4
organism:Humans
action:potentiator
Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217.
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-4
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA4
locus:4p12
cellular-location:Cell junction
transmembrane-regions:259-280 285-306 318-340 524-543
signal-regions:1-35
theoretical-pi:10.0
molecular-weight:61622.645
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4078GenAtlasGABRA4GenBank Gene DatabaseU30461GenBank Protein Database905393IUPHAR407UniProtKBP48169UniProt AccessionGBRA4_HUMAN
synonyms:GABA(A) receptor subunit alpha-4
amino-acid-sequence:>lcl|BSEQ0018959|Gamma-aminobutyric acid receptor subunit alpha-4 MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV YLSKDTMEKSESLM
gene-sequence:>lcl|BSEQ0018960|Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) ATGGTTTCTGCCAAGAAGGTACCCGCGATCGCTCTGTCCGCCGGGGTCAGTTTCGCCCTC CTGCGCTTCCTGTGCCTGGCGGTTTGTTTAAACGAATCCCCAGGACAGAACCAAAAGGAG GAGAAATTGTGCACAGAAAATTTCACCCGCATCCTGGACAGTTTGCTCGATGGTTATGAC AACAGGCTGCGTCCTGGATTTGGGGGTCCTGTTACAGAAGTGAAAACTGACATATATGTC ACCAGCTTTGGACCTGTTTCTGATGTTGAAATGGAATACACAATGGATGTGTTCTTCAGG CAGACATGGATTGACAAAAGATTAAAATATGACGGCCCCATTGAAATTTTGAGATTGAAC AATATGATGGTAACGAAAGTGTGGACCCCTGATACTTTCTTCAGGAATGGAAAGAAATCT GTCTCACATAATATGACAGCTCCAAATAAGCTTTTTAGAATTATGAGAAATGGTACTATT TTATACACAATGAGACTCACCATAAGTGCGGAGTGTCCCATGAGATTGGTGGATTTTCCC ATGGATGGTCATGCATGCCCTTTGAAATTCGGGAGTTATGCCTATCCAAAGAGTGAGATG ATCTATACCTGGACAAAAGGTCCTGAGAAATCAGTTGAAGTTCCGAAGGAGTCTTCCAGC TTAGTTCAATATGATTTGATTGGGCAAACCGTATCAAGTGAAACCATCAAATCAATTACG GGTGAATATATTGTTATGACGGTTTACTTCCACCTCAGACGGAAGATGGGTTATTTTATG ATTCAGACCTATATTCCGTGCATTATGACAGTGATTCTTTCTCAAGTTTCATTTTGGATA AATAAAGAATCAGTTCCCGCTAGGACTGTATTTGGAATAACAACTGTCCTCACCATGACC ACACTAAGCATCAGTGCACGACATTCTTTGCCCAAAGTGTCCTATGCTACCGCCATGGAC TGGTTCATAGCTGTCTGCTTTGCTTTTGTATTTTCGGCCCTTATCGAGTTTGCTGCTGTC AACTATTTCACCAATATTCAAATGGAAAAAGCCAAAAGGAAGACATCAAAGCCCCCTCAG GAAGTTCCCGCTGCTCCAGTGCAGAGAGAGAAGCATCCTGAAGCCCCTCTGCAGAATACA AATGCCAATTTGAACATGAGAAAAAGAACAAATGCTTTGGTTCACTCTGAATCTGATGTT GGCAACAGAACTGAGGTGGGAAACCATTCAAGCAAATCTTCCACAGTTGTTCAAGAATCT TCTAAAGGCACACCTCGGTCTTACTTAGCTTCCAGTCCAAACCCATTCAGCCGTGCAAAT GCAGCTGAAACCATATCTGCAGCAAGAGCACTTCCATCTGCTTCTCCTACTTCTATCCGA ACTGGATATATGCCTCGAAAGGCTTCAGTTGGATCTGCTTCTACTCGTCACGTGTTTGGA TCAAGACTGCAGAGGATAAAGACCACAGTTAATACCATAGGGGCTACTGGGAAGTTGTCA GCTACTCCTCCTCCATCGGCTCCACCACCTTCTGGATCTGGCACAAGTAAAATAGACAAA TATGCCCGTATTCTCTTTCCAGTCACATTTGGGGCATTTAACATGGTTTATTGGGTTGTT TATTTATCTAAGGACACTATGGAGAAATCAGAAAGTCTAATGTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscentral nervous system developmentprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessregulation of response to drugprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
id:BE0000471
name:Gamma-aminobutyric acid receptor subunit alpha-5
organism:Humans
action:potentiator
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217.
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-5
general-function:Transporter activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA5
locus:15q11.2-q12
cellular-location:Cell junction
transmembrane-regions:260-281 286-307 319-341 428-449
signal-regions:1-31
theoretical-pi:9.56
molecular-weight:52145.645
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4079GenAtlasGABRA5GenBank Gene DatabaseL08485GenBank Protein Database182916IUPHAR408Guide to Pharmacology408UniProtKBP31644UniProt AccessionGBRA5_HUMAN
synonyms:GABA(A) receptor subunit alpha-5
amino-acid-sequence:>lcl|BSEQ0010331|Gamma-aminobutyric acid receptor subunit alpha-5 MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
gene-sequence:>lcl|BSEQ0010332|Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) ATGGACAATGGAATGTTCTCTGGTTTTATCATGATCAAAAACCTCCTTCTCTTTTGTATT TCCATGAACTTATCCAGTCACTTTGGCTTTTCACAGATGCCAACCAGTTCAGTGAAAGAT GAGACCAATGACAACATCACGATATTTACCAGGATCTTGGATGGGCTCTTGGATGGCTAC GACAACAGACTTCGGCCCGGGCTGGGAGAGCGCATCACTCAGGTGAGGACCGACATCTAC GTCACCAGCTTCGGCCCGGTGTCCGACACGGAAATGGAGTACACCATAGACGTGTTTTTC CGACAAAGCTGGAAAGATGAAAGGCTTCGGTTTAAGGGGCCCATGCAGCGCCTCCCTCTC AACAACCTCCTTGCCAGCAAGATCTGGACCCCAGACACGTTCTTCCACAACGGGAAGAAG TCCATCGCTCACAACATGACCACGCCCAACAAGCTGCTGCGGCTGGAGGACGACGGCACC CTGCTCTACACCATGCGCTTGACCATCTCTGCAGAGTGCCCCATGCAGCTTGAGGACTTC CCGATGGATGCGCACGCTTGCCCTCTGAAATTTGGCAGCTATGCGTACCCTAATTCTGAA GTCGTTTACGTCTGGACCAACGGCTCCACCAAGTCGGTGGTGGTGGCGGAAGATGGCTCC AGACTGAACCAGTACCACCTGATGGGGCAGACGGTGGGCACTGAGAACATCAGCACCAGC ACAGGCGAATACACAATCATGACAGCTCACTTCCACCTGAAAAGGAAGATTGGCTACTTT GTCATCCAGACCTACCTTCCCTGCATAATGACCGTGATCTTATCACAGGTGTCCTTTTGG CTGAACCGGGAATCAGTCCCAGCCAGGACAGTTTTTGGGGTCACCACGGTGCTGACCATG ACGACCCTCAGCATCAGCGCCAGGAACTCTCTGCCCAAAGTGGCCTACGCCACCGCCATG GACTGGTTCATAGCCGTGTGCTATGCCTTCGTCTTCTCGGCGCTGATAGAGTTTGCCACG GTCAATTACTTTACCAAGAGAGGCTGGGCCTGGGATGGCAAAAAAGCCTTGGAAGCAGCC AAGATCAAGAAAAAGCGTGAAGTCATACTAAATAAGTCAACAAACGCTTTTACAACTGGG AAGATGTCTCACCCCCCAAACATTCCGAAGGAACAGACCCCAGCAGGGACGTCGAATACA ACCTCAGTCTCAGTAAAACCCTCTGAAGAGAAGACTTCTGAAAGCAAAAAGACTTACAAC AGTATCAGCAAAATTGACAAAATGTCCCGAATCGTATTCCCAGTCTTGTTCGGCACTTTC AACTTAGTTTACTGGGCAACGTATTTGAATAGGGAGCCGGTGATAAAAGGAGCCGCCTCT CCAAAATAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentdendritecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentneuronal cell body membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityfunctionreceptor activityfunctiontransporter activityprocessassociative learningprocessbehavioral fear responseprocessbrain developmentprocesschloride transmembrane transportprocesscochlea developmentprocessgamma-aminobutyric acid signaling pathwayprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessmitophagy in response to mitochondrial depolarizationprocessnegative regulation of neuron apoptotic processprocessneurological system processprocesspositive regulation of defense response to virus by hostprocessregulation of membrane potentialprocessresponse to drugprocesssensory perception of soundprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransportprocessxenophagy
id:BE0000764
name:Gamma-aminobutyric acid receptor subunit alpha-6
organism:Humans
action:potentiator
Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217.
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-6
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA6
locus:5q34
cellular-location:Cell junction
transmembrane-regions:243-264 269-290 301-324 420-441
signal-regions:1-19
theoretical-pi:8.4
molecular-weight:51023.69
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4080GenAtlasGABRA6GenBank Gene DatabaseS81944GenBank Protein Database1470364IUPHAR409Guide to Pharmacology409UniProtKBQ16445UniProt AccessionGBRA6_HUMAN
synonyms:GABA(A) receptor subunit alpha-6
amino-acid-sequence:>lcl|BSEQ0010540|Gamma-aminobutyric acid receptor subunit alpha-6 MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
gene-sequence:>lcl|BSEQ0010541|Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) ATGGCGTCGTCTCTGCCCTGGCTGTGCATTATTCTGTGGCTAGAAAATGCCCTAGGGAAA CTCGAAGTTGAAGGCAACTTCTACTCAGAAAACGTCAGTCGGATCCTGGACAACTTGCTT GAAGGCTATGACAATCGGCTGCGGCCGGGATTTGGAGGTGCTGTCACTGAAGTCAAAACA GACATTTATGTGACCAGTTTTGGGCCCGTGTCAGATGTGGAGATGGAGTATACGATGGAT GTTTTTTTCCGCCAGACCTGGACTGATGAGAGGTTGAAGTTTGGGGGGCCAACTGAGATT CTGAGTCTGAATAATTTGATGGTCAGTAAAATCTGGACGCCTGACACCTTTTTCAGAAAT GGTAAAAAGTCCATTGCTCACAACATGACAACTCCTAATAAACTCTTCAGAATAATGCAG AATGGAACCATTTTATACACCATGAGGCTTACCATCAATGCTGACTGTCCCATGAGGCTG GTTAACTTTCCTATGGATGGGCATGCTTGTCCACTCAAGTTTGGGAGCTATGCTTATCCC AAAAGTGAAATCATATATACGTGGAAAAAAGGACCACTTTACTCAGTAGAAGTCCCAGAA GAATCTTCAAGCCTTCTCCAGTATGATCTGATTGGACAAACAGTATCTAGTGAGACAATT AAATCTAACACAGGTGAATACGTTATAATGACAGTTTACTTCCACTTGCAAAGGAAGATG GGCTACTTCATGATACAGATATACACTCCTTGCATTATGACAGTCATTCTTTCCCAGGTG TCTTTCTGGATTAATAAGGAGTCCGTCCCAGCAAGAACTGTTTTTGGGATCACCACTGTT TTAACTATGACCACTTTGAGCATCAGTGCCCGGCACTCTTTGCCAAAAGTGTCATATGCC ACTGCCATGGATTGGTTCATAGCTGTTTGCTTTGCATTCGTCTTCTCTGCGCTTATCGAG TTCGCAGCTGTCAACTACTTTACCAATCTTCAGACACAGAAGGCCAAAAGGAAGGCACAG TTTGCAGCCCCACCCACAGTGACAATATCAAAAGCTACTGAACCTTTGGAAGCTGAGATT GTTTTGCATCCTGACTCCAAATATCATCTGAAGAAAAGGATCACTTCTCTGTCTTTGCCA ATAGTTTCATCTTCCGAGGCCAATAAAGTGCTCACGAGAGCGCCCATCTTACAATCAACA CCTGTCACACCCCCACCACTCTCGCCAGCCTTTGGAGGCACCAGTAAAATAGACCAGTAT TCTCGAATTCTCTTCCCAGTTGCATTTGCAGGATTCAACCTTGTGTACTGGGTAGTTTAT CTTTCCAAAGATACAATGGAAGTCAGTAGCAGTGTTGAATAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
id:BE0000849
name:Neuronal acetylcholine receptor subunit alpha-4
organism:Humans
action:antagonist
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72.
Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303.
known-action:unknown
name:Neuronal acetylcholine receptor subunit alpha-4
general-function:Ligand-gated ion channel activity
specific-function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
gene-name:CHRNA4
locus:20q13.2-q13.3
cellular-location:Cell junction
transmembrane-regions:243-267 275-293 309-330 601-619
signal-regions:1-28
theoretical-pi:7.21
molecular-weight:69956.47
chromosome-location:20
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1958GenAtlasCHRNA4GenBank Gene DatabaseL35901GenBank Protein Database755648IUPHAR465Guide to Pharmacology465UniProtKBP43681UniProt AccessionACHA4_HUMAN
synonyms:NACRA4
amino-acid-sequence:>lcl|BSEQ0001694|Neuronal acetylcholine receptor subunit alpha-4 MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR IFLWMFIIVCLLGTVGLFLPPWLAGMI
gene-sequence:>lcl|BSEQ0016224|Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) ATGGAGCTAGGGGGCCCCGGAGCGCCGCGGCTGCTGCCGCCGCTGCTGCTGCTTCTGGGG ACCGGCCTCCTGCGCGCCAGCAGCCATGTGGAGACCCGGGCCCACGCCGAGGAGCGGCTC CTGAAGAAACTCTTCTCCGGTTACAACAAGTGGTCCCGACCCGTGGCCAACATCTCGGAC GTGGTCCTCGTCCGCTTCGGCCTGTCCATCGCTCAGCTCATTGACGTGGATGAGAAGAAC CAGATGATGACCACGAACGTATGGGTGAAGCAGGAGTGGCACGACTACAAGCTGCGCTGG GACCCAGCTGACTATGAGAATGTCACCTCCATCCGCATCCCCTCCGAGCTCATCTGGCGG CCGGACATCGTCCTCTACAACAATGCTGACGGGGACTTCGCGGTCACCCACCTGACCAAG GCCCACCTGTTCCATGACGGGCGGGTGCAGTGGACTCCCCCGGCCATTTACAAGAGCTCC TGCAGCATCGACGTCACCTTCTTCCCCTTCGACCAGCAGAACTGCACCATGAAATTCGGC TCCTGGACCTACGACAAGGCCAAGATCGACCTGGTGAACATGCACAGCCGCGTGGACCAG CTGGACTTCTGGGAGAGTGGCGAGTGGGTCATCGTGGATGCCGTGGGCACCTACAACACC AGGAAGTACGAGTGCTGTGCCGAGATCTACCCGGACATCACCTATGCCTTCGTCATCCGG CGGCTGCCGCTCTTCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTCCTGCCTC ACCGTGCTGGTCTTCTACCTGCCCTCCGAGTGTGGCGAGAAGATCACGCTGTGCATCTCC GTGCTGCTGTCGCTCACCGTCTTCCTGCTGCTCATCACCGAGATCATCCCGTCCACCTCA CTGGTCATCCCACTCATCGGCGAGTACCTGCTGTTCACCATGATCTTCGTCACCCTGTCC ATCGTCATCACGGTCTTCGTGCTCAACGTGCACCACCGCTCGCCACGCACGCACACCATG CCCACCTGGGTACGCAGGGTCTTCCTGGACATCGTGCCACGCCTGCTCCTCATGAAGCGG CCGTCCGTGGTCAAGGACAATTGCCGGCGGCTCATCGAGTCCATGCATAAGATGGCCAGT GCCCCGCGCTTCTGGCCCGAGCCAGAAGGGGAGCCCCCTGCCACGAGCGGCACCCAGAGC CTGCACCCGCCCTCACCGTCCTTCTGTGTCCCCCTGGATGTGCCGGCTGAGCCTGGGCCT TCCTGCAAGTCACCCTCCGACCAGCTCCCTCCTCAGCAGCCCCTGGAAGCTGAGAAAGCC AGCCCCCACCCCTCGCCTGGACCCTGCCGCCCGCCCCACGGCACCCAGGCACCAGGGCTG GCCAAAGCCAGGTCCCTCAGCGTCCAGCACATGTCCAGCCCTGGCGAAGCGGTGGAAGGC GGCGTCCGGTGCCGGTCTCGGAGCATCCAGTACTGTGTTCCCCGAGACGATGCCGCCCCC GAGGCAGATGGCCAGGCTGCCGGCGCCCTGGCCTCTCGCAACACCCACTCGGCTGAGCTC CCACCCCCAGACCAGCCCTCTCCGTGCAAATGCACATGCAAGAAGGAGCCCTCTTCGGTG TCCCCGAGCGCCACGGTCAAGACCCGCAGCACCAAAGCGCCGCCCCCGCACCTGCCCCTG TCGCCGGCCCTGACCCGGGCGGTGGAGGGCGTCCAGTACATTGCAGACCACCTGAAGGCC GAAGACACAGACTTCTCGGTGAAGGAGGACTGGAAGTACGTGGCCATGGTCATCGACCGC ATCTTCCTCTGGATGTTCATCATCGTCTGCCTGCTGGGGACGGTGGGCCTCTTCCTGCCG CCCTGGCTGGCTGGCATGATCTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentacetylcholine-gated channel complexcomponentcell junctioncomponentdendritecomponentexternal side of plasma membranecomponentintegral component of membranecomponentmembranecomponentneuron projectioncomponentneuronal cell bodycomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionacetylcholine bindingfunctionacetylcholine receptor activityfunctionacetylcholine-activated cation-selective channel activityfunctionligand-gated ion channel activityprocessaction potentialprocessB cell activationprocessbehavioral response to nicotineprocesscalcium ion transportprocesscation transmembrane transportprocesscognitionprocessDNA repairprocessexploration behaviorprocessinhibitory postsynaptic potentialprocession transmembrane transportprocession transportprocesslocomotory behaviorprocessmembrane depolarizationprocessneurological system processprocessneuromuscular synaptic transmissionprocessregulation of dopamine secretionprocessregulation of membrane potentialprocessrespiratory gaseous exchangeprocessresponse to hypoxiaprocessresponse to nicotineprocessresponse to oxidative stressprocesssensory perception of painprocesssignal transductionprocesssynaptic transmissionprocesssynaptic transmission, cholinergic
id:BE0002341
name:Neuronal acetylcholine receptor subunit alpha-7
organism:Humans
action:antagonist
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72.
Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303.
known-action:unknown
name:Neuronal acetylcholine receptor subunit alpha-7
general-function:Toxic substance binding
specific-function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
gene-name:CHRNA7
locus:15q14
cellular-location:Cell junction
transmembrane-regions:231-255 262-280 296-317 470-490
signal-regions:1-22
theoretical-pi:6.44
molecular-weight:56448.925
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1960GenAtlasCHRNA7GenBank Gene DatabaseX70297GenBank Protein Database496607IUPHAR468Guide to Pharmacology468UniProtKBP36544UniProt AccessionACHA7_HUMAN
synonyms:NACHRA7
amino-acid-sequence:>lcl|BSEQ0004597|Neuronal acetylcholine receptor subunit alpha-7 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI ICTIGILMSAPNFVEAVSKDFA
gene-sequence:>lcl|BSEQ0020606|Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) ATGCGCTGCTCGCCGGGAGGCGTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGTGTCC CTGCAAGGCGAGTTCCAGAGGAAGCTTTACAAGGAGCTGGTCAAGAACTACAATCCCTTG GAGAGGCCCGTGGCCAATGACTCGCAACCACTCACCGTCTACTTCTCCCTGAGCCTCCTG CAGATCATGGACGTGGATGAGAAGAACCAAGTTTTAACCACCAACATTTGGCTGCAAATG TCTTGGACAGATCACTATTTACAGTGGAATGTGTCAGAATATCCAGGGGTGAAGACTGTT CGTTTCCCAGATGGCCAGATTTGGAAACCAGACATTCTTCTCTATAACAGTGCTGATGAG CGCTTTGACGCCACATTCCACACTAACGTGTTGGTGAATTCTTCTGGGCATTGCCAGTAC CTGCCTCCAGGCATATTCAAGAGTTCCTGCTACATCGATGTACGCTGGTTTCCCTTTGAT GTGCAGCACTGCAAACTGAAGTTTGGGTCCTGGTCTTACGGAGGCTGGTCCTTGGATCTG CAGATGCAGGAGGCAGATATCAGTGGCTATATCCCCAATGGAGAATGGGACCTAGTGGGA ATCCCCGGCAAGAGGAGTGAAAGGTTCTATGAGTGCTGCAAAGAGCCCTACCCCGATGTC ACCTTCACAGTGACCATGCGCCGCAGGACGCTCTACTATGGCCTCAACCTGCTGATCCCC TGTGTGCTCATCTCCGCCCTCGCCCTGCTGGTGTTCCTGCTTCCTGCAGATTCCGGGGAG AAGATTTCCCTGGGGATAACAGTCTTACTCTCTCTTACCGTCTTCATGCTGCTCGTGGCT GAGATCATGCCCGCAACATCCGATTCGGTACCATTGATAGCCCAGTACTTCGCCAGCACC ATGATCATCGTGGGCCTCTCGGTGGTGGTGACAGTGATCGTGCTGCAGTACCACCACCAC GACCCCGACGGGGGCAAGATGCCCAAGTGGACCAGAGTCATCCTTCTGAACTGGTGCGCG TGGTTCCTGCGAATGAAGAGGCCCGGGGAGGACAAGGTGCGCCCGGCCTGCCAGCACAAG CAGCGGCGCTGCAGCCTGGCCAGTGTGGAGATGAGCGCCGTGGCGCCGCCGCCCGCCAGC AACGGGAACCTGCTGTACATCGGCTTCCGCGGCCTGGACGGCGTGCACTGTGTCCCGACC CCCGACTCTGGGGTAGTGTGTGGCCGCATGGCCTGCTCCCCCACGCACGATGAGCACCTC CTGCACGGCGGGCAACCCCCCGAGGGGGACCCGGACTTGGCCAAGATCCTGGAGGAGGTC CGCTACATTGCCAACCGCTTCCGCTGCCAGGACGAAAGCGAGGCGGTCTGCAGCGAGTGG AAGTTCGCCGCCTGTGTGGTGGACCGCCTGTGCCTCATGGCCTTCTCGGTCTTCACCATC ATCTGCACCATCGGCATCCTGATGTCGGCTCCCAACTTCGTGGAGGCCGTGTCCAAAGAC TTTGCGTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentacetylcholine-gated channel complexcomponentapical plasma membranecomponentasymmetric synapsecomponentaxolemmacomponentcell junctioncomponentcytoplasmcomponentdendritic shaftcomponentdendritic spinecomponentexternal side of plasma membranecomponentgrowth conecomponentintegral component of membranecomponentmembrane raftcomponentneuron projectioncomponentneuronal cell bodycomponentplasma membranecomponentpostsynaptic densitycomponentpostsynaptic membranecomponentpresynaptic membranecomponentsynapsefunctionacetylcholine bindingfunctionacetylcholine receptor activityfunctionacetylcholine-activated cation-selective channel activityfunctionacetylcholine-gated cation channel activityfunctionbeta-amyloid bindingfunctionchloride channel regulator activityfunctiondrug bindingfunctionprotein homodimerization activityfunctiontoxic substance bindingprocessactivation of MAPK activityprocessassociative learningprocessB cell activationprocessbehavioral response to ethanolprocessbehavioral response to nicotineprocesscalcium ion transportprocesscation transmembrane transportprocesscellular calcium ion homeostasisprocesscognitionprocessdopamine biosynthetic processprocessendocytosisprocessgeneration of ovulation cycle rhythmprocession transmembrane transportprocession transportprocessmemoryprocessnegative regulation of inflammatory responseprocessnegative regulation of interleukin-1 beta productionprocessnegative regulation of interleukin-6 productionprocessnegative regulation of tumor necrosis factor productionprocessneuronal action potentialprocesspositive regulation of angiogenesisprocesspositive regulation of cell proliferationprocesspositive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressureprocessregulation of membrane potentialprocessregulation of norepinephrine secretionprocessregulation of synaptic transmission, dopaminergicprocessresponse to foodprocessresponse to hypoxiaprocessresponse to nicotineprocesssignal transductionprocesssperm motilityprocesssynaptic transmissionprocesssynaptic transmission, cholinergicprocessT cell activation
id:BE0000829
name:Glutamate receptor 2
organism:Humans
action:antagonist
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303.
known-action:unknown
name:Glutamate receptor 2
general-function:Ionotropic glutamate receptor activity
specific-function:Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
gene-name:GRIA2
locus:4q32-q33
cellular-location:Cell membrane
transmembrane-regions:544-564 617-637 813-833
signal-regions:1-24
theoretical-pi:7.66
molecular-weight:98820.32
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4572GenAtlasGRIA2GenBank Gene DatabaseL20814GenBank Protein Database493134IUPHAR445Guide to Pharmacology445UniProtKBP42262UniProt AccessionGRIA2_HUMAN
synonyms:AMPA-selective glutamate receptor 2GluA2GluR-2GluR-BGluR-K2GLUR2Glutamate receptor ionotropic, AMPA 2
amino-acid-sequence:>lcl|BSEQ0001654|Glutamate receptor 2 MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV GNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALT YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR AEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
gene-sequence:>lcl|BSEQ0016219|Glutamate receptor 2 (GRIA2) ATGCAAAAGATTATGCATATTTCTGTCCTCCTTTCTCCTGTTTTATGGGGACTGATTTTT GGTGTCTCTTCTAACAGCATACAGATAGGGGGGCTATTTCCTAGGGGCGCCGATCAAGAA TACAGTGCATTTCGAGTAGGGATGGTTCAGTTTTCCACTTCGGAGTTCAGACTGACACCC CACATCGACAATTTGGAGGTGGCAAACAGCTTCGCAGTCACTAATGCTTTCTGCTCCCAG TTTTCGAGAGGAGTCTATGCTATTTTTGGATTTTATGACAAGAAGTCTGTAAATACCATC ACATCATTTTGCGGAACACTCCACGTCTCCTTCATCACTCCCAGCTTCCCAACAGATGGC ACACATCCATTTGTCATTCAGATGAGACCCGACCTCAAAGGAGCTCTCCTTAGCTTGATT GAATACTATCAATGGGACAAGTTTGCATACCTCTATGACAGTGACAGAGGCTTATCAACA CTGCAAGCTGTGCTGGATTCTGCTGCTGAAAAGAAATGGCAAGTGACTGCTATCAATGTG GGAAACATTAACAATGACAAGAAAGATGAGATGTACCGATCACTTTTTCAAGATCTGGAG TTAAAAAAGGAACGGCGTGTAATTCTGGACTGTGAAAGGGATAAAGTAAACGACATTGTA GACCAGGTTATTACCATTGGAAAACATGTTAAAGGGTACCACTACATCATTGCAAATCTG GGATTTACTGATGGAGACCTATTAAAAATCCAGTTTGGAGGTGCAAATGTCTCTGGATTT CAGATAGTGGACTATGATGATTCGTTGGTATCTAAATTTATAGAAAGATGGTCAACACTG GAAGAAAAAGAATACCCTGGAGCTCACACAACAACAATTAAGTATACTTCTGCTCTGACC TATGATGCCGTTCAAGTGATGACTGAAGCCTTCCGCAACCTAAGGAAGCAAAGAATTGAA ATCTCCCGAAGGGGGAATGCAGGAGACTGTCTGGCAAACCCAGCAGTGCCCTGGGGACAA GGTGTAGAAATAGAAAGGGCCCTCAAACAGGTTCAGGTTGAAGGTCTCTCAGGAAATATA AAGTTTGACCAGAATGGAAAAAGAATAAACTATACAATTAACATCATGGAGCTCAAAACT AATGGGCCCCGGAAGATTGGCTACTGGAGTGAAGTGGACAAAATGGTTGTTACCCTTACT GAGCTCCCTTCTGGAAATGACACCTCTGGGCTTGAGAATAAGACTGTTGTTGTCACCACA ATTTTGGAATCTCCGTATGTTATGATGAAGAAAAATCATGAAATGCTTGAAGGCAATGAG CGCTATGAGGGCTACTGTGTTGACCTGGCTGCAGAAATCGCCAAACATTGTGGGTTCAAG TACAAGTTGACAATTGTTGGTGATGGCAAGTATGGGGCCAGGGATGCAGACACGAAAATT TGGAATGGGATGGTTGGAGAACTTGTATATGGGAAAGCTGATATTGCAATTGCTCCATTA ACTATTACCCTTGTGAGAGAAGAGGTGATTGACTTCTCAAAGCCCTTCATGAGCCTCGGG ATATCTATCATGATCAAGAAGCCTCAGAAGTCCAAACCAGGAGTGTTTTCCTTTCTTGAT CCTTTAGCCTATGAGATCTGGATGTGCATTGTTTTTGCCTACATTGGGGTCAGTGTAGTT TTATTCCTGGTCAGCAGATTTAGCCCCTACGAGTGGCACACTGAGGAGTTTGAAGATGGA AGAGAAACACAAAGTAGTGAATCAACTAATGAATTTGGGATTTTTAATAGTCTCTGGTTT TCCTTGGGTGCCTTTATGCGGCAAGGATGCGATATTTCGCCAAGATCCCTCTCTGGGCGC ATTGTTGGAGGTGTGTGGTGGTTCTTTACCCTGATCATAATCTCCTCCTACACGGCTAAC TTAGCTGCCTTCCTGACTGTAGAGAGGATGGTGTCTCCCATCGAAAGTGCTGAGGATCTT TCTAAGCAAACAGAAATTGCTTATGGAACATTAGACTCTGGCTCCACTAAAGAGTTTTTC AGGAGATCTAAAATTGCAGTGTTTGATAAAATGTGGACCTACATGCGGAGTGCGGAGCCC TCTGTGTTTGTGAGGACTACGGCCGAAGGGGTGGCTAGAGTGCGGAAGTCCAAAGGGAAA TATGCCTACTTGTTGGAGTCCACGATGAACGAGTACATTGAGCAAAGGAAGCCTTGCGAC ACCATGAAAGTTGGTGGAAACCTGGATTCCAAAGGCTATGGCATCGCAACACCTAAAGGA TCCTCATTAAGAACCCCAGTAAATCTTGCAGTATTGAAACTCAGTGAGCAAGGCGTCTTA GACAAGCTGAAAAACAAATGGTGGTACGATAAAGGTGAATGTGGAGCCAAGGACTCTGGA AGTAAGGAAAAGACCAGTGCCCTCAGTCTGAGCAACGTTGCTGGAGTATTCTACATCCTT GTCGGGGGCCTTGGTTTGGCAATGCTGGTGGCTTTGATTGAGTTCTGTTACAAGTCAAGG GCCGAGGCGAAACGAATGAAGGTGGCAAAGAATGCACAGAATATTAACCCATCTTCCTCG CAGAATTCACAGAATTTTGCAACTTATAAGGAAGGTTACAACGTATATGGCATCGAAAGT GTTAAAATTTAG
pfams:PF01094ANF_receptorPF00060Lig_chanPF10613Lig_chan-Glu_bd
go-classifiers:componentAMPA glutamate receptor complexcomponentcell junctioncomponentdendritecomponentendocytic vesicle membranecomponentendoplasmic reticulum membranecomponentintegral component of plasma membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynaptic vesiclefunctionAMPA glutamate receptor activityfunctionextracellular-glutamate-gated ion channel activityfunctionionotropic glutamate receptor activityprocession transmembrane transportprocessionotropic glutamate receptor signaling pathwayprocesssignal transductionprocesssynaptic transmissionprocesssynaptic transmission, glutamatergic
id:BE0000826
name:Glutamate receptor ionotropic, kainate 2
organism:Humans
action:antagonist
Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.
Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303.
known-action:unknown
name:Glutamate receptor ionotropic, kainate 2
general-function:Kainate selective glutamate receptor activity
specific-function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).
gene-name:GRIK2
locus:6q16.3-q21
cellular-location:Cell membrane
transmembrane-regions:562-582 636-656 820-840
signal-regions:1-31
theoretical-pi:8.01
molecular-weight:102582.475
chromosome-location:6
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4580GenAtlasGRIK2GenBank Gene DatabaseU16126GenBank Protein Database790532IUPHAR451UniProtKBQ13002UniProt AccessionGRIK2_HUMAN
synonyms:EAA4Excitatory amino acid receptor 4GluK2GluR-6GLUR6Glutamate receptor 6
amino-acid-sequence:>lcl|BSEQ0001648|Glutamate receptor ionotropic, kainate 2 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR LPGKETMA
gene-sequence:>lcl|BSEQ0020488|Glutamate receptor ionotropic, kainate 2 (GRIK2) ATGAAGATTATTTTCCCGATTCTAAGTAATCCAGTCTTCAGGCGCACCGTTAAACTCCTG CTCTGTTTACTGTGGATTGGATATTCTCAAGGAACCACACATGTATTAAGATTTGGTGGT ATTTTTGAATATGTGGAATCTGGCCCAATGGGAGCTGAGGAACTTGCATTCAGATTTGCT GTGAACACAATTAACAGAAACAGAACATTGCTACCCAATACTACCCTTACCTATGATACC CAGAAGATAAACCTTTATGATAGTTTTGAAGCATCCAAGAAAGCCTGTGATCAGCTGTCT CTTGGGGTGGCTGCCATCTTCGGGCCTTCACACAGCTCATCAGCAAACGCAGTGCAGTCC ATCTGCAATGCTCTGGGAGTTCCCCACATACAGACCCGCTGGAAGCACCAGGTGTCAGAC AACAAAGATTCCTTCTATGTCAGTCTCTACCCAGACTTCTCTTCACTCAGCCGTGCCATT TTAGACCTGGTGCAGTTTTTCAAGTGGAAAACCGTCACGGTTGTGTATGATGACAGCACT GGTCTCATTCGTTTGCAAGAGCTCATCAAAGCTCCATCAAGGTATAATCTTCGACTCAAA ATTCGTCAGTTACCTGCTGATACAAAGGATGCAAAACCCTTACTAAAAGAAATGAAAAGA GGCAAGGAGTTTCATGTAATCTTTGATTGTAGCCATGAAATGGCAGCAGGCATTTTAAAA CAGGCATTAGCTATGGGAATGATGACAGAATACTATCATTATATCTTTACCACTCTGGAC CTCTTTGCTCTTGATGTTGAGCCCTACCGATACAGTGGTGTTAACATGACAGGGTTCAGA ATATTAAATACAGAAAATACCCAAGTCTCCTCCATCATTGAAAAGTGGTCGATGGAACGA TTGCAGGCACCTCCGAAACCCGATTCAGGTTTGCTGGATGGATTTATGACGACTGATGCT GCTCTAATGTATGATGCTGTGCATGTGGTGTCTGTGGCCGTTCAACAGTTTCCCCAGATG ACAGTCAGTTCCTTGCAGTGTAATCGACATAAACCCTGGCGCTTCGGGACCCGCTTTATG AGTCTAATTAAAGAGGCACATTGGGAAGGCCTCACAGGCAGAATAACTTTCAACAAAACC AATGGCTTGAGAACAGATTTTGATTTGGATGTGATCAGTCTGAAGGAAGAAGGTCTAGAA AAGATTGGAACGTGGGATCCAGCCAGTGGCCTGAATATGACAGAAAGTCAAAAGGGAAAG CCAGCGAACATCACAGATTCCTTATCCAATCGTTCTTTGATTGTTACCACCATTTTGGAA GAGCCTTATGTCCTTTTTAAGAAGTCTGACAAACCTCTCTATGGTAATGATCGATTTGAA GGCTATTGCATTGATCTCCTCAGAGAGTTATCTACAATCCTTGGCTTTACATATGAAATT AGACTTGTGGAAGATGGGAAATATGGAGCCCAGGATGATGCCAATGGACAATGGAATGGA ATGGTTCGTGAACTAATTGATCATAAAGCTGACCTTGCAGTTGCTCCACTGGCTATTACC TATGTTCGAGAGAAGGTCATCGACTTTTCCAAGCCCTTTATGACACTTGGAATAAGTATT TTGTACCGCAAGCCCAATGGTACAAACCCAGGCGTCTTCTCCTTCCTGAATCCTCTCTCC CCTGATATCTGGATGTATATTCTGCTGGCTTACTTGGGTGTCAGTTGTGTGCTCTTTGTC ATAGCCAGGTTTAGTCCTTATGAGTGGTATAATCCACACCCTTGCAACCCTGACTCAGAC GTGGTGGAAAACAATTTTACCTTGCTAAATAGTTTCTGGTTTGGAGTTGGAGCTCTCATG CAGCAAGGTTCTGAGCTCATGCCCAAAGCACTGTCCACCAGGATAGTGGGAGGCATTTGG TGGTTTTTCACACTTATCATCATTTCTTCGTATACTGCTAACTTAGCCGCCTTTCTGACA GTGGAACGCATGGAATCCCCTATTGACTCTGCTGATGATTTAGCTAAACAAACCAAGATA GAATATGGAGCAGTAGAGGATGGTGCAACCATGACTTTTTTCAAGAAATCAAAAATCTCC ACGTATGACAAAATGTGGGCCTTTATGAGTAGCAGAAGGCAGTCAGTGCTGGTCAAAAGT AATGAAGAAGGAATCCAGCGAGTCCTCACCTCTGATTATGCTTTCCTAATGGAGTCAACA ACCATCGAGTTTGTTACCCAGCGGAACTGTAACCTGACACAGATTGGCGGCCTTATAGAC TCTAAAGGTTATGGCGTTGGCACTCCCATGGGTTCTCCATATCGAGACAAAATTACCATA GCAATTCTTCAGCTGCAAGAGGAAGGCAAACTGCATATGATGAAGGAGAAATGGTGGAGG GGCAATGGTTGCCCAGAAGAGGAGAGCAAAGAGGCCAGTGCCCTGGGGGTTCAGAATATT GGTGGCATCTTCATTGTTCTGGCAGCCGGCTTGGTGCTTTCAGTTTTTGTGGCAGTGGGA GAATTTTTATACAAATCCAAAAAAAACGCTCAATTGGAAAAGAGAGCCAAGACTAAGTTA CCTCAAGACTATGTATTCCTCCCTATTTTGGAGTCAGTTTCCATTTCTACAGTGTTGTCA TCATCACCATCTTCATCATCATTATCATCATGTTCTTAA
pfams:PF01094ANF_receptorPF00060Lig_chanPF10613Lig_chan-Glu_bd
go-classifiers:componentcell junctioncomponentdendritecomponentdendrite cytoplasmcomponentintegral component of plasma membranecomponentkainate selective glutamate receptor complexcomponentperikaryoncomponentplasma membranecomponentpostsynaptic densitycomponentpostsynaptic membranecomponentpresynaptic membranecomponentterminal boutonfunctionextracellular-glutamate-gated ion channel activityfunctionkainate selective glutamate receptor activityprocessbehavioral fear responseprocesscellular calcium ion homeostasisprocessexcitatory postsynaptic potentialprocessglutamate receptor signaling pathwayprocessinhibitory postsynaptic potentialprocessintracellular protein transportprocession transmembrane transportprocessionotropic glutamate receptor signaling pathwayprocessmodulation of synaptic transmissionprocessnegative regulation of neuron apoptotic processprocessnegative regulation of synaptic transmission, glutamatergicprocessneuron apoptotic processprocessneuronal action potentialprocesspositive regulation of neuron apoptotic processprocesspositive regulation of synaptic transmissionprocessreceptor clusteringprocessregulation of JNK cascadeprocessregulation of long-term neuronal synaptic plasticityprocessregulation of short-term neuronal synaptic plasticityprocesssynaptic transmissionprocesssynaptic transmission, glutamatergicprocesstransport
id:BE0004797
name:GABA(A) Receptor
organism:Humans
action:positive allosteric modulator
known-action:yes
name:Gamma-aminobutyric acid receptor subunit alpha-1
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
gene-name:GABRA1
locus:5q34-q35
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 422-443
signal-regions:1-27
theoretical-pi:9.61
molecular-weight:51801.395
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4075GenAtlasGABRA1GenBank Gene DatabaseX13584GenBank Protein Database31631IUPHAR404Guide to Pharmacology404UniProtKBP14867UniProt AccessionGBRA1_HUMAN
synonyms:GABA(A) receptor subunit alpha-1
amino-acid-sequence:>lcl|BSEQ0010561|Gamma-aminobutyric acid receptor subunit alpha-1 MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
gene-sequence:>lcl|BSEQ0010562|Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) ATGAGGAAAAGTCCAGGTCTGTCTGACTGTCTTTGGGCCTGGATCCTCCTTCTGAGCACA CTGACTGGAAGAAGCTATGGACAGCCGTCATTACAAGATGAACTTAAAGACAATACCACT GTCTTCACCAGGATTTTGGACAGACTCCTAGATGGTTATGACAATCGCCTGAGACCAGGA TTGGGAGAGCGTGTAACCGAAGTGAAGACTGATATCTTCGTCACCAGTTTCGGACCCGTT TCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAA AGGTTAAAATTTAAAGGACCTATGACAGTCCTCCGGTTAAATAACCTAATGGCAAGTAAA ATCTGGACTCCGGACACATTTTTCCACAATGGAAAGAAGTCAGTGGCCCACAACATGACC ATGCCCAACAAACTCCTGCGGATCACAGAGGATGGCACCTTGCTGTACACCATGAGGCTG ACAGTGAGAGCTGAATGTCCGATGCATTTGGAGGACTTCCCTATGGATGCCCATGCTTGC CCACTAAAATTTGGAAGTTATGCTTATACAAGAGCAGAAGTTGTTTATGAATGGACCAGA GAGCCAGCACGCTCAGTGGTTGTAGCAGAAGATGGATCACGTCTAAACCAGTATGACCTT CTTGGACAAACAGTAGACTCTGGAATTGTCCAGTCAAGTACAGGAGAATATGTTGTTATG ACCACTCATTTCCACTTGAAGAGAAAGATTGGCTACTTTGTTATTCAAACATACCTGCCA TGCATAATGACAGTGATTCTCTCACAAGTCTCCTTCTGGCTCAACAGAGAGTCTGTACCA GCAAGAACTGTCTTTGGAGTAACAACTGTGCTCACCATGACAACATTGAGCATCAGTGCC AGAAACTCCCTCCCTAAGGTGGCTTATGCAACAGCTATGGATTGGTTTATTGCCGTGTGC TATGCCTTTGTGTTCTCAGCTCTGATTGAGTTTGCCACAGTAAACTATTTCACTAAGAGA GGTTATGCATGGGATGGCAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTAAAGGATCCT CTTATTAAGAAAAACAACACTTACGCTCCAACAGCAACCAGCTACACCCCTAATTTGGCC AGGGGCGACCCGGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCTAAAGAGGTC AAGCCCGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGTCAGCAAAATTGAC CGACTGTCAAGAATAGCCTTCCCGCTGCTATTTGGAATCTTTAACTTAGTCTACTGGGCT ACGTATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACACCACATCAATAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA receptor complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctiondrug bindingfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA2
locus:4p12
cellular-location:Cell junction
transmembrane-regions:252-273 279-300 313-334 420-441
signal-regions:1-28
theoretical-pi:9.41
molecular-weight:51325.85
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4076GenAtlasGABRA2GenBank Gene DatabaseS62907GenBank Protein Database386422IUPHAR405Guide to Pharmacology405UniProtKBP47869UniProt AccessionGBRA2_HUMAN
synonyms:GABA(A) receptor subunit alpha-2
amino-acid-sequence:>lcl|BSEQ0037005|Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
gene-sequence:>lcl|BSEQ0010268|Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) ATGAAGACAAAATTGAACATCTACAACATGCAGTTCCTGCTTTTTGTTTTCTTGGTGTGG GACCCTGCCAGGTTGGTGCTGGCTAACATCCAAGAAGATGAGGCTAAAAATAACATTACC ATCTTTACGAGAATTCTTGACAGACTTCTGGATGGTTACGATAATCGGCTTAGACCAGGA CTGGGAGACAGTATTACTGAAGTCTTCACTAACATCTACGTGACCAGTTTTGGCCCTGTC TCAGATACAGATATGGAATATACAATTGATGTTTTCTTTCGACAAAAATGGAAAGATGAA CGTTTAAAATTTAAAGGTCCTATGAATATCCTTCGACTAAACAATTTAATGGCTAGCAAA ATCTGGACTCCAGATACCTTTTTTCACAATGGGAAAAAATCAGTAGCTCATAATATGACA ATGCCAAATAAGTTGCTTCGAATTCAGGATGATGGGACTCTGCTGTATACCATGAGGCTT ACAGTTCAAGCTGAATGCCCAATGCACTTGGAGGATTTCCCAATGGATGCTCATTCATGT CCTCTGAAATTTGGCAGCTATGCATATACAACTTCAGAGGTCACTTATATTTGGACTTAC AATGCATCTGATTCAGTACAGGTTGCTCCTGATGGCTCTAGGTTAAATCAATATGACCTG CTGGGCCAATCAATCGGAAAGGAGACAATTAAATCCAGTACAGGTGAATATACTGTAATG ACAGCTCATTTCCACCTGAAAAGAAAAATTGGGTATTTTGTGATTCAAACCTATCTGCCT TGCATCATGACTGTCATTCTCTCCCAAGTTTCATTCTGGCTTAACAGAGAATCTGTGCCT GCAAGAACTGTGTTTGGAGTAACAACTGTCCTAACAATGACAACTCTAAGCATCAGTGCT CGGAATTCTCTCCCCAAAGTGGCTTATGCAACTGCCATGGACTGGTTTATTGCTGTTTGT TATGCATTTGTGTTCTCTGCCCTAATTGAATTTGCAACTGTTAATTACTTCACCAAAAGA GGATGGGCTTGGGATGGGAAGAGTGTAGTAAATGACAAGAAAAAAGAAAAGGCTTCCGTT ATGATACAGAACAACGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAA GATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGAAGCCA GAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATG TCCAGAATAGTTTTTCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATAT TTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentaxoncomponentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentintegral component of synaptic vesicle membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessneurotransmitter transportprocessregulation of membrane potentialprocessregulation of neurotransmitter levelsprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transport
name:Gamma-aminobutyric acid receptor subunit alpha-3
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA3
locus:Xq28
cellular-location:Cell junction
transmembrane-regions:277-298 304-325 338-359 458-479
signal-regions:1-28
theoretical-pi:8.93
molecular-weight:55164.055
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4077GenAtlasGABRA3GenBank Gene DatabaseS62908GenBank Protein Database386424IUPHAR406Guide to Pharmacology406UniProtKBP34903UniProt AccessionGBRA3_HUMAN
synonyms:GABA(A) receptor subunit alpha-3
amino-acid-sequence:>lcl|BSEQ0016119|Gamma-aminobutyric acid receptor subunit alpha-3 MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDS TDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQ TWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLL YTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRL NQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN RESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN YFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGA APSASSTPTIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVN RESAIKGMIRKQ
gene-sequence:>lcl|BSEQ0016120|Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3) ATGATAATCACACAAACAAGTCACTGTTACATGACCAGCCTTGGGATTCTTTTCCTGATT AATATTCTCCCTGGAACCACTGGTCAAGGGGAATCAAGACGACAAGAACCCGGGGACTTT GTGAAGCAGGACATTGGCGGGCTGTCTCCTAAGCATGCCCCAGATATTCCTGATGACAGC ACTGACAACATCACTATCTTCACCAGAATCTTGGATCGTCTTCTGGACGGCTATGACAAC CGGCTGCGACCTGGGCTTGGAGATGCAGTGACTGAAGTGAAGACTGACATCTACGTGACC AGTTTTGGCCCTGTGTCAGACACTGACATGGAGTACACTATTGATGTATTTTTTCGGCAG ACATGGCATGATGAAAGACTGAAATTTGATGGCCCCATGAAGATCCTTCCACTGAACAAT CTCCTGGCTAGTAAGATCTGGACACCGGACACCTTCTTCCACAATGGCAAGAAATCAGTG GCTCATAACATGACCACGCCCAACAAGCTGCTCAGATTGGTGGACAACGGAACCCTCCTC TATACAATGAGGTTAACAATTCATGCTGAGTGTCCCATGCATTTGGAAGATTTTCCCATG GATGTGCATGCCTGCCCACTGAAGTTTGGAAGCTATGCCTATACAACAGCTGAAGTGGTT TATTCTTGGACTCTCGGAAAGAACAAATCCGTGGAAGTGGCACAGGATGGTTCTCGCTTG AACCAGTATGACCTTTTGGGCCATGTTGTTGGGACAGAGATAATCCGGTCTAGTACAGGA GAATATGTCGTCATGACAACCCACTTCCATCTCAAGCGAAAAATTGGCTACTTTGTGATC CAGACCTACTTGCCATGTATCATGACTGTCATTCTGTCACAAGTGTCGTTCTGGCTCAAC AGAGAGTCTGTTCCTGCCCGTACAGTCTTTGGTGTCACCACTGTGCTTACCATGACCACC TTGAGTATCAGTGCCAGAAATTCCTTACCTAAAGTGGCATATGCGACGGCCATGGACTGG TTCATAGCCGTCTGTTATGCCTTTGTATTTTCTGCACTGATTGAATTTGCCACTGTCAAC TATTTCACCAAGCGGAGTTGGGCTTGGGAAGGCAAGAAGGTGCCAGAGGCCCTGGAGATG AAGAAGAAAACACCAGCAGCCCCAGCAAAGAAAACCAGCACTACCTTCAACATCGTGGGG ACCACCTATCCCATCAACCTGGCCAAGGACACTGAATTTTCCACCATCTCCAAGGGCGCT GCTCCCAGTGCCTCCTCAACCCCAACAATCATTGCTTCACCCAAGGCCACCTACGTGCAG GACAGCCCGACTGAGACCAAGACCTACAACAGTGTCAGCAAGGTTGACAAAATTTCCCGC ATCATCTTTCCTGTGCTCTTTGCCATATTCAATCTGGTCTATTGGGCCACATATGTCAAC CGGGAGTCAGCTATCAAGGGCATGATCCGCAAACAGTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-4
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA4
locus:4p12
cellular-location:Cell junction
transmembrane-regions:259-280 285-306 318-340 524-543
signal-regions:1-35
theoretical-pi:10.0
molecular-weight:61622.645
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4078GenAtlasGABRA4GenBank Gene DatabaseU30461GenBank Protein Database905393IUPHAR407UniProtKBP48169UniProt AccessionGBRA4_HUMAN
synonyms:GABA(A) receptor subunit alpha-4
amino-acid-sequence:>lcl|BSEQ0018959|Gamma-aminobutyric acid receptor subunit alpha-4 MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV YLSKDTMEKSESLM
gene-sequence:>lcl|BSEQ0018960|Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) ATGGTTTCTGCCAAGAAGGTACCCGCGATCGCTCTGTCCGCCGGGGTCAGTTTCGCCCTC CTGCGCTTCCTGTGCCTGGCGGTTTGTTTAAACGAATCCCCAGGACAGAACCAAAAGGAG GAGAAATTGTGCACAGAAAATTTCACCCGCATCCTGGACAGTTTGCTCGATGGTTATGAC AACAGGCTGCGTCCTGGATTTGGGGGTCCTGTTACAGAAGTGAAAACTGACATATATGTC ACCAGCTTTGGACCTGTTTCTGATGTTGAAATGGAATACACAATGGATGTGTTCTTCAGG CAGACATGGATTGACAAAAGATTAAAATATGACGGCCCCATTGAAATTTTGAGATTGAAC AATATGATGGTAACGAAAGTGTGGACCCCTGATACTTTCTTCAGGAATGGAAAGAAATCT GTCTCACATAATATGACAGCTCCAAATAAGCTTTTTAGAATTATGAGAAATGGTACTATT TTATACACAATGAGACTCACCATAAGTGCGGAGTGTCCCATGAGATTGGTGGATTTTCCC ATGGATGGTCATGCATGCCCTTTGAAATTCGGGAGTTATGCCTATCCAAAGAGTGAGATG ATCTATACCTGGACAAAAGGTCCTGAGAAATCAGTTGAAGTTCCGAAGGAGTCTTCCAGC TTAGTTCAATATGATTTGATTGGGCAAACCGTATCAAGTGAAACCATCAAATCAATTACG GGTGAATATATTGTTATGACGGTTTACTTCCACCTCAGACGGAAGATGGGTTATTTTATG ATTCAGACCTATATTCCGTGCATTATGACAGTGATTCTTTCTCAAGTTTCATTTTGGATA AATAAAGAATCAGTTCCCGCTAGGACTGTATTTGGAATAACAACTGTCCTCACCATGACC ACACTAAGCATCAGTGCACGACATTCTTTGCCCAAAGTGTCCTATGCTACCGCCATGGAC TGGTTCATAGCTGTCTGCTTTGCTTTTGTATTTTCGGCCCTTATCGAGTTTGCTGCTGTC AACTATTTCACCAATATTCAAATGGAAAAAGCCAAAAGGAAGACATCAAAGCCCCCTCAG GAAGTTCCCGCTGCTCCAGTGCAGAGAGAGAAGCATCCTGAAGCCCCTCTGCAGAATACA AATGCCAATTTGAACATGAGAAAAAGAACAAATGCTTTGGTTCACTCTGAATCTGATGTT GGCAACAGAACTGAGGTGGGAAACCATTCAAGCAAATCTTCCACAGTTGTTCAAGAATCT TCTAAAGGCACACCTCGGTCTTACTTAGCTTCCAGTCCAAACCCATTCAGCCGTGCAAAT GCAGCTGAAACCATATCTGCAGCAAGAGCACTTCCATCTGCTTCTCCTACTTCTATCCGA ACTGGATATATGCCTCGAAAGGCTTCAGTTGGATCTGCTTCTACTCGTCACGTGTTTGGA TCAAGACTGCAGAGGATAAAGACCACAGTTAATACCATAGGGGCTACTGGGAAGTTGTCA GCTACTCCTCCTCCATCGGCTCCACCACCTTCTGGATCTGGCACAAGTAAAATAGACAAA TATGCCCGTATTCTCTTTCCAGTCACATTTGGGGCATTTAACATGGTTTATTGGGTTGTT TATTTATCTAAGGACACTATGGAGAAATCAGAAAGTCTAATGTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscentral nervous system developmentprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessregulation of response to drugprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit alpha-5
general-function:Transporter activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA5
locus:15q11.2-q12
cellular-location:Cell junction
transmembrane-regions:260-281 286-307 319-341 428-449
signal-regions:1-31
theoretical-pi:9.56
molecular-weight:52145.645
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4079GenAtlasGABRA5GenBank Gene DatabaseL08485GenBank Protein Database182916IUPHAR408Guide to Pharmacology408UniProtKBP31644UniProt AccessionGBRA5_HUMAN
synonyms:GABA(A) receptor subunit alpha-5
amino-acid-sequence:>lcl|BSEQ0010331|Gamma-aminobutyric acid receptor subunit alpha-5 MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGY DNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPL NNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDF PMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTS TGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAA KIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
gene-sequence:>lcl|BSEQ0010332|Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5) ATGGACAATGGAATGTTCTCTGGTTTTATCATGATCAAAAACCTCCTTCTCTTTTGTATT TCCATGAACTTATCCAGTCACTTTGGCTTTTCACAGATGCCAACCAGTTCAGTGAAAGAT GAGACCAATGACAACATCACGATATTTACCAGGATCTTGGATGGGCTCTTGGATGGCTAC GACAACAGACTTCGGCCCGGGCTGGGAGAGCGCATCACTCAGGTGAGGACCGACATCTAC GTCACCAGCTTCGGCCCGGTGTCCGACACGGAAATGGAGTACACCATAGACGTGTTTTTC CGACAAAGCTGGAAAGATGAAAGGCTTCGGTTTAAGGGGCCCATGCAGCGCCTCCCTCTC AACAACCTCCTTGCCAGCAAGATCTGGACCCCAGACACGTTCTTCCACAACGGGAAGAAG TCCATCGCTCACAACATGACCACGCCCAACAAGCTGCTGCGGCTGGAGGACGACGGCACC CTGCTCTACACCATGCGCTTGACCATCTCTGCAGAGTGCCCCATGCAGCTTGAGGACTTC CCGATGGATGCGCACGCTTGCCCTCTGAAATTTGGCAGCTATGCGTACCCTAATTCTGAA GTCGTTTACGTCTGGACCAACGGCTCCACCAAGTCGGTGGTGGTGGCGGAAGATGGCTCC AGACTGAACCAGTACCACCTGATGGGGCAGACGGTGGGCACTGAGAACATCAGCACCAGC ACAGGCGAATACACAATCATGACAGCTCACTTCCACCTGAAAAGGAAGATTGGCTACTTT GTCATCCAGACCTACCTTCCCTGCATAATGACCGTGATCTTATCACAGGTGTCCTTTTGG CTGAACCGGGAATCAGTCCCAGCCAGGACAGTTTTTGGGGTCACCACGGTGCTGACCATG ACGACCCTCAGCATCAGCGCCAGGAACTCTCTGCCCAAAGTGGCCTACGCCACCGCCATG GACTGGTTCATAGCCGTGTGCTATGCCTTCGTCTTCTCGGCGCTGATAGAGTTTGCCACG GTCAATTACTTTACCAAGAGAGGCTGGGCCTGGGATGGCAAAAAAGCCTTGGAAGCAGCC AAGATCAAGAAAAAGCGTGAAGTCATACTAAATAAGTCAACAAACGCTTTTACAACTGGG AAGATGTCTCACCCCCCAAACATTCCGAAGGAACAGACCCCAGCAGGGACGTCGAATACA ACCTCAGTCTCAGTAAAACCCTCTGAAGAGAAGACTTCTGAAAGCAAAAAGACTTACAAC AGTATCAGCAAAATTGACAAAATGTCCCGAATCGTATTCCCAGTCTTGTTCGGCACTTTC AACTTAGTTTACTGGGCAACGTATTTGAATAGGGAGCCGGTGATAAAAGGAGCCGCCTCT CCAAAATAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentdendritecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentneuronal cell body membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityfunctionreceptor activityfunctiontransporter activityprocessassociative learningprocessbehavioral fear responseprocessbrain developmentprocesschloride transmembrane transportprocesscochlea developmentprocessgamma-aminobutyric acid signaling pathwayprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessmitophagy in response to mitochondrial depolarizationprocessnegative regulation of neuron apoptotic processprocessneurological system processprocesspositive regulation of defense response to virus by hostprocessregulation of membrane potentialprocessresponse to drugprocesssensory perception of soundprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransportprocessxenophagy
name:Gamma-aminobutyric acid receptor subunit alpha-6
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRA6
locus:5q34
cellular-location:Cell junction
transmembrane-regions:243-264 269-290 301-324 420-441
signal-regions:1-19
theoretical-pi:8.4
molecular-weight:51023.69
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4080GenAtlasGABRA6GenBank Gene DatabaseS81944GenBank Protein Database1470364IUPHAR409Guide to Pharmacology409UniProtKBQ16445UniProt AccessionGBRA6_HUMAN
synonyms:GABA(A) receptor subunit alpha-6
amino-acid-sequence:>lcl|BSEQ0010540|Gamma-aminobutyric acid receptor subunit alpha-6 MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
gene-sequence:>lcl|BSEQ0010541|Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) ATGGCGTCGTCTCTGCCCTGGCTGTGCATTATTCTGTGGCTAGAAAATGCCCTAGGGAAA CTCGAAGTTGAAGGCAACTTCTACTCAGAAAACGTCAGTCGGATCCTGGACAACTTGCTT GAAGGCTATGACAATCGGCTGCGGCCGGGATTTGGAGGTGCTGTCACTGAAGTCAAAACA GACATTTATGTGACCAGTTTTGGGCCCGTGTCAGATGTGGAGATGGAGTATACGATGGAT GTTTTTTTCCGCCAGACCTGGACTGATGAGAGGTTGAAGTTTGGGGGGCCAACTGAGATT CTGAGTCTGAATAATTTGATGGTCAGTAAAATCTGGACGCCTGACACCTTTTTCAGAAAT GGTAAAAAGTCCATTGCTCACAACATGACAACTCCTAATAAACTCTTCAGAATAATGCAG AATGGAACCATTTTATACACCATGAGGCTTACCATCAATGCTGACTGTCCCATGAGGCTG GTTAACTTTCCTATGGATGGGCATGCTTGTCCACTCAAGTTTGGGAGCTATGCTTATCCC AAAAGTGAAATCATATATACGTGGAAAAAAGGACCACTTTACTCAGTAGAAGTCCCAGAA GAATCTTCAAGCCTTCTCCAGTATGATCTGATTGGACAAACAGTATCTAGTGAGACAATT AAATCTAACACAGGTGAATACGTTATAATGACAGTTTACTTCCACTTGCAAAGGAAGATG GGCTACTTCATGATACAGATATACACTCCTTGCATTATGACAGTCATTCTTTCCCAGGTG TCTTTCTGGATTAATAAGGAGTCCGTCCCAGCAAGAACTGTTTTTGGGATCACCACTGTT TTAACTATGACCACTTTGAGCATCAGTGCCCGGCACTCTTTGCCAAAAGTGTCATATGCC ACTGCCATGGATTGGTTCATAGCTGTTTGCTTTGCATTCGTCTTCTCTGCGCTTATCGAG TTCGCAGCTGTCAACTACTTTACCAATCTTCAGACACAGAAGGCCAAAAGGAAGGCACAG TTTGCAGCCCCACCCACAGTGACAATATCAAAAGCTACTGAACCTTTGGAAGCTGAGATT GTTTTGCATCCTGACTCCAAATATCATCTGAAGAAAAGGATCACTTCTCTGTCTTTGCCA ATAGTTTCATCTTCCGAGGCCAATAAAGTGCTCACGAGAGCGCCCATCTTACAATCAACA CCTGTCACACCCCCACCACTCTCGCCAGCCTTTGGAGGCACCAGTAAAATAGACCAGTAT TCTCGAATTCTCTTCCCAGTTGCATTTGCAGGATTCAACCTTGTGTACTGGGTAGTTTAT CTTTCCAAAGATACAATGGAAGTCAGTAGCAGTGTTGAATAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit beta-1
general-function:Ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
gene-name:GABRB1
locus:4p12
cellular-location:Cell junction
transmembrane-regions:246-267 271-293 305-327 452-473
signal-regions:1-25
theoretical-pi:9.01
molecular-weight:54234.085
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4081GenAtlasGABRB1GenBank Gene DatabaseX14767GenBank Protein Database31635IUPHAR410UniProtKBP18505UniProt AccessionGBRB1_HUMAN
synonyms:GABA(A) receptor subunit beta-1
amino-acid-sequence:>lcl|BSEQ0004603|Gamma-aminobutyric acid receptor subunit beta-1 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
gene-sequence:>lcl|BSEQ0020610|Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1) ATGTGGACAGTACAAAATCGAGAGAGTCTGGGGCTTCTCTCTTTCCCTGTGATGATTACC ATGGTCTGTTGTGCACACAGCACCAATGAACCCAGCAACATGTCATACGTGAAAGAGACA GTGGACAGATTGCTCAAAGGATATGACATTCGCTTGCGGCCGGACTTCGGAGGGCCCCCC GTCGACGTTGGGATGCGGATCGATGTCGCCAGCATAGACATGGTCTCCGAAGTGAATATG GATTATACACTCACCATGTATTTCCAGCAGTCTTGGAAAGACAAAAGGCTTTCTTATTCT GGAATCCCACTGAACCTCACCCTAGACAATAGGGTAGCTGACCAACTCTGGGTACCAGAC ACCTACTTTCTGAATGACAAGAAATCATTTGTGCATGGGGTCACAGTGAAAAATCGAATG ATTCGACTGCATCCTGATGGAACAGTTCTCTATGGACTCCGAATCACAACCACAGCTGCA TGTATGATGGATCTTCGAAGATATCCACTGGATGAGCAGAACTGCACCCTGGAGATCGAA AGTTATGGCTATACCACTGATGACATTGAATTTTACTGGAATGGAGGAGAAGGGGCAGTC ACTGGTGTTAATAAAATCGAACTTCCTCAATTTTCAATTGTTGACTACAAGATGGTGTCT AAGAAGGTGGAGTTCACAACAGGAGCGTATCCACGACTGTCACTAAGTTTTCGTCTAAAG AGAAACATTGGTTACTTCATTTTGCAAACCTACATGCCTTCTACACTGATTACAATTCTG TCCTGGGTGTCTTTTTGGATCAACTATGATGCATCTGCAGCCAGAGTCGCACTAGGAATC ACGACAGTGCTTACAATGACAACCATCAGCACCCACCTCAGGGAGACCCTGCCAAAGATC CCTTATGTCAAAGCGATTGATATTTATCTGATGGGTTGCTTTGTGTTTGTGTTCCTGGCT CTGCTGGAGTATGCCTTTGTAAATTACATCTTCTTTGGGAAAGGCCCTCAGAAAAAGGGA GCTAGCAAACAAGACCAGAGTGCCAATGAGAAGAATAAACTGGAGATGAATAAAGTCCAG GTCGACGCCCACGGTAACATTCTCCTCAGCACCCTGGAAATCCGGAATGAGACGAGTGGC TCGGAAGTGCTCACGAGCGTGAGCGACCCCAAGGCCACCATGTACTCCTATGACAGCGCC AGCATCCAGTACCGCAAGCCCCTGAGCAGCCGCGAGGCCTACGGGCGCGCCCTGGACCGG CACGGGGTACCCAGCAAGGGGCGCATCCGCAGGCGTGCCTCCCAGCTCAAAGTCAAGATC CCCGACTTGACTGATGTGAATTCCATAGACAAGTGGTCCCGAATGTTTTTCCCCATCACC TTTTCTCTTTTTAATGTCGTCTATTGGCTTTACTATGTACACTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentcytoplasmcomponentdendritecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentnuclear envelopecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityfunctionligand-gated ion channel activityprocesscellular response to histamineprocesscentral nervous system neuron developmentprocesschloride transmembrane transportprocession transmembrane transportprocession transportprocessneurological system processprocessovulation cycleprocessregulation of membrane potentialprocessresponse to progesteroneprocessresponse to toxic substanceprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit beta-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
gene-name:GABRB2
locus:5q34
cellular-location:Cell junction
transmembrane-regions:245-266 270-292 304-326 490-511
signal-regions:1-25
theoretical-pi:9.66
molecular-weight:59149.895
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4082GenAtlasGABRB2GenBank Gene DatabaseS67368GenBank Protein Database455946IUPHAR411UniProtKBP47870UniProt AccessionGBRB2_HUMAN
synonyms:GABA(A) receptor subunit beta-2
amino-acid-sequence:>lcl|BSEQ0037195|Gamma-aminobutyric acid receptor subunit beta-2 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKI FYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEA VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
gene-sequence:>lcl|BSEQ0011685|Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) ATGTGGAGAGTGCGGAAAAGGGGCTACTTTGGGATTTGGTCCTTCCCCTTAATAATCGCC GCTGTCTGTGCGCAGAGTGTCAATGACCCTAGTAATATGTCGCTGGTTAAAGAGACGGTG GATAGACTCCTGAAAGGCTATGACATTCGTCTGAGACCAGATTTTGGAGGTCCCCCCGTG GCTGTGGGGATGAACATTGACATTGCCAGCATCGATATGGTTTCTGAAGTCAATATGGAT TATACCTTGACAATGTACTTTCAACAAGCCTGGAGAGATAAGAGGCTGTCCTATAATGTA ATACCTTTAAACTTGACTCTGGACAACAGAGTGGCAGACCAGCTCTGGGTGCCTGATACC TATTTCCTGAACGATAAGAAGTCATTTGTGCACGGAGTGACTGTTAAGAACCGCATGATT CGCCTGCATCCTGATGGCACCGTCCTTTATGGACTCAGAATCACAACCACAGCTGCCTGC ATGATGGACCTAAGGAGGTACCCACTGGATGAACAAAACTGCACCTTGGAAATTGAGAGC TATGGATACACAACTGATGACATTGAGTTTTACTGGCGTGGCGATGATAATGCAGTAACA GGAGTAACGAAAATTGAACTTCCACAGTTCTCTATTGTAGATTACAAACTTATCACCAAG AAGGTTGTTTTTTCCACAGGTTCCTATCCCAGGTTATCCCTCAGCTTTAAGCTTAAGAGA AACATTGGCTACTTTATCCTGCAAACATACATGCCTTCCATCCTGATTACCATCCTCTCC TGGGTCTCCTTCTGGATTAATTACGATGCTTCAGCTGCAAGGGTGGCATTAGGAATCACA ACTGTCCTCACAATGACCACAATCAACACCCACCTCCGGGAAACTCTCCCTAAAATCCCC TATGTGAAGGCCATTGACATGTACCTGATGGGGTGCTTTGTCTTCGTTTTCATGGCCCTT CTGGAATATGCCCTAGTCAACTACATCTTCTTTGGGAGGGGGCCCCAACGCCAAAAGAAA GCAGCTGAGAAGGCTGCCAGTGCCAACAATGAGAAGATGCGCCTGGATGTCAACAAGATG GACCCCCATGAGAACATCTTACTGAGCACTCTCGAGATAAAAAATGAAATGGCCACATCT GAGGCTGTGATGGGACTTGGAGACCCCAGAAGCACAATGCTAGCCTATGATGCCTCCAGC ATCCAGTATCGGAAAGCTGGGTTGCCCAGGCATAGTTTTGGCCGAAATGCTCTGGAACGA CATGTGGCGCAAAAGAAAAGTCGCCTGAGGAGACGCGCCTCCCAACTGAAAATCACCATC CCTGACTTGACTGATGTGAATGCCATAGATCGGTGGTCCCGCATATTCTTCCCAGTGGTT TTTTCCTTCTTCAACATCGTCTATTGGCTTTATTATGTGAACTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentcytosolcomponentextracellular exosomecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocesscochlea developmentprocessgamma-aminobutyric acid signaling pathwayprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessnegative regulation of neuron apoptotic processprocessneurological system processprocessregulation of membrane potentialprocesssensory perception of soundprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit beta-3
general-function:Gaba-gated chloride ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
gene-name:GABRB3
locus:15q11.2-q12
cellular-location:Cell junction
transmembrane-regions:246-267 271-293 305-327 451-472
signal-regions:1-25
theoretical-pi:9.41
molecular-weight:54115.04
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4083GenAtlasGABRB3GenBank Gene DatabaseM82919GenBank Protein Database182925IUPHAR412Guide to Pharmacology412UniProtKBP28472UniProt AccessionGBRB3_HUMAN
synonyms:GABA(A) receptor subunit beta-3
amino-acid-sequence:>lcl|BSEQ0004605|Gamma-aminobutyric acid receptor subunit beta-3 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
gene-sequence:>lcl|BSEQ0016761|Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) ATGTGGGGCCTTGCGGGAGGAAGGCTTTTCGGCATCTTCTCGGCCCCGGTGCTGGTGGCT GTGGTGTGCTGCGCCCAGAGTGTGAACGATCCCGGGAACATGTCCTTTGTGAAGGAGACG GTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAGACCCGACTTCGGGGGTCCCCCG GTCTGCGTGGGGATGAACATCGACATCGCCAGCATCGACATGGTTTCCGAAGTCAACATG GATTATACCTTAACCATGTATTTTCAACAATATTGGAGAGATAAAAGGCTCGCCTATTCT GGGATCCCTCTCAACCTCACGCTTGACAATCGAGTGGCTGACCAGCTATGGGTGCCCGAC ACATATTTCTTAAATGACAAAAAGTCATTTGTGCATGGAGTGACAGTGAAAAACCGCATG ATCCGTCTTCACCCTGATGGGACAGTGCTGTATGGGCTCAGAATCACCACGACAGCAGCA TGCATGATGGACCTCAGGAGATACCCCCTGGACGAGCAGAACTGCACTCTGGAAATTGAA AGCTATGGCTACACCACGGATGACATTGAGTTTTACTGGCGAGGCGGGGACAAGGCTGTT ACCGGAGTGGAAAGGATTGAGCTCCCGCAGTTCTCCATCGTGGAGCACCGTCTGGTCTCG AGGAATGTTGTCTTCGCCACAGGTGCCTATCCTCGACTGTCACTGAGCTTTCGGTTGAAG AGGAACATTGGATACTTCATTCTTCAGACTTATATGCCCTCTATACTGATAACGATTCTG TCGTGGGTGTCCTTCTGGATCAATTATGATGCATCTGCTGCTAGAGTTGCCCTCGGGATC ACAACTGTGCTGACAATGACAACCATCAACACCCACCTTCGGGAGACCTTGCCCAAAATC CCCTATGTCAAAGCCATTGACATGTACCTTATGGGCTGCTTCGTCTTTGTGTTCCTGGCC CTTCTGGAGTATGCCTTTGTCAACTACATTTTCTTTGGAAGAGGCCCTCAAAGGCAGAAG AAGCTTGCAGAAAAGACAGCCAAGGCAAAGAATGACCGTTCAAAGAGCGAAAGCAACCGG GTGGATGCTCATGGAAATATTCTGTTGACATCGCTGGAAGTTCACAATGAAATGAATGAG GTCTCAGGCGGCATTGGCGATACCAGGAATTCAGCAATATCCTTTGACAACTCAGGAATC CAGTACAGGAAACAGAGCATGCCTCGAGAAGGGCATGGGCGATTCCTGGGGGACAGAAGC CTCCCGCACAAGAAGACCCATCTACGGAGGAGGTCTTCACAGCTCAAAATTAAAATACCT GATCTAACCGATGTGAATGCCATAGACAGATGGTCCAGGATCGTGTTTCCATTCACTTTT TCTCTTTTCAACTTAGTTTACTGGCTGTACTATGTTAACTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityfunctionGABA-gated chloride ion channel activityprocesscellular response to histamineprocesschloride transmembrane transportprocesscochlea developmentprocessinhibitory postsynaptic potentialprocessinner ear receptor cell developmentprocessinnervationprocession transmembrane transportprocessnegative regulation of neuron apoptotic processprocessneurological system processprocesspalate developmentprocessregulation of membrane potentialprocesssensory perception of soundprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit delta
general-function:Gaba-a receptor activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRD
locus:1p|1p36.3
cellular-location:Cell junction
transmembrane-regions:249-271 275-297 309-331 430-452
signal-regions:1-16
theoretical-pi:8.73
molecular-weight:50707.835
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4084GenBank Gene DatabaseAF016917GenBank Protein Database2388693UniProtKBO14764UniProt AccessionGBRD_HUMAN
synonyms:GABA(A) receptor subunit delta
amino-acid-sequence:>lcl|BSEQ0012501|Gamma-aminobutyric acid receptor subunit delta MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIG GPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLW LPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECML DLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLH FHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSS LPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAI VLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM
gene-sequence:>lcl|BSEQ0012502|Gamma-aminobutyric acid receptor subunit delta (GABRD) ATGGACGCGCCCGCCCGGCTGCTGGCCCCGCTCCTGCTCCTCTGCGCGCAGCAGCTCCGC GGCACCAGAGCGATGAATGACATCGGCGACTACGTGGGCTCCAACCTGGAGATCTCCTGG CTCCCCAACCTGGACGGGCTGATAGCCGGCTACGCCCGCAACTTCCGGCCTGGCATCGGA GGCCCCCCCGTGAATGTGGCCCTTGCCCTGGAGGTGGCCAGCATCGACCACATCTCAGAG GCCAACATGGAGTACACCATGACGGTGTTCCTGCACCAGAGCTGGCGGGACAGCAGGCTC TCCTACAACCACACCAACGAGACCCTGGGTCTGGACAGCCGCTTCGTGGACAAGCTGTGG CTGCCCGACACCTTCATCGTGAACGCCAAGTCGGCCTGGTTCCACGACGTGACGGTGGAG AACAAGCTCATCCGGCTGCAGCCCGACGGCGTGATCCTGTACAGCATCCGAATCACCTCC ACTGTGGCCTGCGACATGGACCTGGCCAAATACCCCATGGACGAGCAGGAGTGCATGCTG GACCTGGAGAGCTACGGTTACTCATCGGAGGACATCGTCTACTACTGGTCGGAGAGCCAG GAGCACATCCACGGGCTGGACAAGCTGCAGCTGGCGCAGTTCACCATCACCAGCTACCGC TTCACCACGGAGCTGATGAACTTCAAGTCCGCTGGCCAGTTCCCACGGCTCAGCCTGCAC TTCCACCTGCGGAGGAACCGCGGCGTGTACATCATCCAATCCTACATGCCCTCCGTCCTG CTGGTCGCCATGTCCTGGGTCTCCTTCTGGATCAGCCAGGCGGCGGTGCCCGCCAGGGTG TCTCTAGGCATCACCACGGTGCTGACGATGACCACGCTCATGGTCAGTGCCCGCTCCTCC CTGCCACGGGCATCAGCCATCAAGGCACTGGACGTCTACTTCTGGATCTGCTATGTCTTC GTGTTTGCCGCCCTGGTGGAGTACGCCTTTGCTCATTTCAACGCCGACTACAGGAAGAAG CAGAAGGCCAAGGTCAAGGTCTCCAGGCCGAGGGCAGAGATGGACGTGAGGAACGCCATT GTCCTCTTCTCCCTCTCTGCTGCCGGCGTCACGCAGGAGCTGGCCATCTCCCGCCGGCAG CGCCGCGTCCCGGGGAACCTGATGGGCTCCTACAGGTCGGTGGGGGTGGAGACAGGGGAG ACGAAGAAGGAGGGGGCAGCCCGCTCAGGAGGCCAGGGGGGCATCCGTGCCCGGCTCAGG CCCATCGACGCAGACACCATTGACATTTACGCCCGCGCTGTGTTCCCTGCGGCGTTTGCG GCCGTCAATGTCATCTACTGGGCGGCATACGCCATGTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityprocesschloride transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocesssignal transductionprocesssynaptic transmissionprocesstransport
name:Gamma-aminobutyric acid receptor subunit epsilon
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRE
locus:
cellular-location:Cell junction
transmembrane-regions:254-274 281-301 344-364 486-506
signal-regions:1-22
theoretical-pi:8.09
molecular-weight:57971.175
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4085GenBank Gene DatabaseU66661GenBank Protein Database1857126UniProtKBP78334UniProt AccessionGBRE_HUMAN
synonyms:GABA(A) receptor subunit epsilon
amino-acid-sequence:>lcl|BSEQ0006923|Gamma-aminobutyric acid receptor subunit epsilon MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETE TGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDI IFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKD GKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSW KLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFW IKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAV LNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEER PSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRL DNYSRVVFPVTFFFFNVLYWLVCLNL
gene-sequence:>lcl|BSEQ0020703|Gamma-aminobutyric acid receptor subunit epsilon (GABRE) ATGTTGTCCAAAGTTCTTCCAGTCCTCCTAGGCATCTTATTGATCCTCCAGTCGAGGGTC GAGGGACCTCAGACTGAATCAAAGAATGAAGCCTCTTCCCGTGATGTTGTCTATGGCCCC CAGCCCCAGCCTCTGGAAAATCAGCTCCTCTCTGAGGAAACAAAGTCAACTGAGACTGAG ACTGGGAGCAGAGTTGGCAAACTGCCAGAAGCCTCTCGCATCCTGAACACTATCCTGAGT AATTATGACCACAAACTGCGCCCTGGCATTGGAGAGAAGCCCACTGTGGTCACTGTTGAG ATCTCCGTCAACAGCCTTGGTCCTCTCTCTATCCTAGACATGGAATACACCATTGACATC ATCTTCTCCCAGACCTGGTACGACGAACGCCTCTGTTACAACGACACCTTTGAGTCTCTT GTTCTGAATGGCAATGTGGTGAGCCAGCTATGGATCCCGGACACCTTTTTTAGGAATTCT AAGAGGACCCACGAGCATGAGATCACCATGCCCAACCAGATGGTCCGCATCTACAAGGAT GGCAAGGTGTTGTACACAATTAGGATGACCATTGATGCCGGATGCTCACTCCACATGCTC AGATTTCCAATGGATTCTCACTCTTGCCCTCTATCTTTCTCTAGCTTTTCCTATCCTGAG AATGAGATGATCTACAAGTGGGAAAATTTCAAGCTTGAAATCAATGAGAAGAACTCCTGG AAGCTCTTCCAGTTTGATTTTACAGGAGTGAGCAACAAAACTGAAATAATCACAACCCCA GTTGGTGACTTCATGGTCATGACGATTTTCTTCAATGTGAGCAGGCGGTTTGGCTATGTT GCCTTTCAAAACTATGTCCCTTCTTCCGTGACCACGATGCTCTCCTGGGTTTCCTTTTGG ATCAAGACAGAGTCTGCTCCAGCCCGGACCTCTCTAGGGATCACCTCTGTTCTGACCATG ACCACGTTGGGCACCTTTTCTCGTAAGAATTTCCCGCGTGTCTCCTATATCACAGCCTTG GATTTCTATATCGCCATCTGCTTCGTCTTCTGCTTCTGCGCTCTGTTGGAGTTTGCTGTG CTCAACTTCCTGATCTACAACCAGACAAAAGCCCATGCTTCTCCTAAACTCCGCCATCCT CGTATCAATAGCCGTGCCCATGCCCGTACCCGTGCACGTTCCCGAGCCTGTGCCCGCCAA CATCAGGAAGCTTTTGTGTGCCAGATTGTCACCACTGAGGGAAGTGATGGAGAGGAGCGC CCGTCTTGCTCAGCCCAGCAGCCCCCTAGCCCAGGTAGCCCTGAGGGTCCCCGCAGCCTC TGCTCCAAGCTGGCCTGCTGTGAGTGGTGCAAGCGTTTTAAGAAGTACTTCTGCATGGTC CCCGATTGTGAGGGCAGTACCTGGCAGCAGGGCCGCCTCTGCATCCATGTCTACCGCCTG GATAACTACTCGAGAGTTGTTTTCCCAGTGACTTTCTTCTTCTTCAATGTGCTCTACTGG CTTGTTTGCCTTAACTTGTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransport
name:Gamma-aminobutyric acid receptor subunit gamma-1
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRG1
locus:4p12
cellular-location:Cell junction
transmembrane-regions:273-294 299-320 332-354 445-465
signal-regions:1-35
theoretical-pi:8.23
molecular-weight:53594.49
chromosome-location:4
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4086GenBank Gene DatabaseAK122845GenBank Protein Database193783776UniProtKBQ8N1C3UniProt AccessionGBRG1_HUMAN
synonyms:GABA(A) receptor subunit gamma-1
amino-acid-sequence:>lcl|BSEQ0012496|Gamma-aminobutyric acid receptor subunit gamma-1 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
gene-sequence:>lcl|BSEQ0012497|Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1) ATGGGTCCTTTGAAAGCTTTTCTCTTCTCCCCTTTTCTTCTGCGGAGTCAAAGTAGAGGG GTGAGGTTGGTCTTCTTGTTACTGACCCTGCATTTGGGAAACTGTGTTGATAAGGCAGAT GATGAAGATGATGAGGATTTAACGGTGAACAAAACCTGGGTCTTGGCCCCAAAAATTCAT GAAGGAGATATCACACAAATTCTGAATTCATTGCTTCAAGGCTATGACAATAAACTTCGT CCAGATATAGGAGTGAGGCCCACAGTAATTGAAACTGATGTTTATGTAAACAGCATTGGA CCAGTTGATCCAATTAATATGGAATATACAATAGATATAATTTTTGCCCAAACCTGGTTT GACAGTCGTTTAAAATTCAATAGTACCATGAAAGTGCTTATGCTTAACAGTAATATGGTT GGAAAAATTTGGATTCCTGACACTTTCTTCAGAAACTCAAGAAAATCTGATGCTCACTGG ATAACAACTCCTAATCGTCTGCTTCGAATTTGGAATGATGGACGAGTTCTGTATACTCTA AGATTGACAATTAATGCAGAATGTTATCTTCAGCTTCATAACTTTCCCATGGATGAACAT TCCTGTCCACTGGAATTTTCAAGCTATGGATACCCTAAAAATGAAATTGAGTATAAGTGG AAAAAGCCCTCCGTAGAAGTGGCTGATCCTAAATACTGGAGATTATATCAGTTTGCATTT GTAGGGTTACGGAACTCAACTGAAATCACTCACACGATCTCTGGGGATTATGTTATCATG ACAATTTTTTTTGACCTGAGCAGAAGAATGGGATATTTCACTATTCAGACCTACATTCCA TGCATTCTGACAGTTGTTCTTTCTTGGGTGTCTTTTTGGATCAATAAAGATGCAGTGCCT GCAAGAACATCGTTGGGTATCACTACAGTTCTGACTATGACAACCCTGAGTACAATTGCC AGGAAGTCTTTACCTAAGGTTTCTTATGTGACTGCGATGGATCTCTTTGTTTCTGTTTGT TTCATTTTTGTTTTTGCAGCCTTGATGGAATATGGAACCTTGCATTATTTTACCAGCAAC CAAAAAGGAAAGACTGCTACTAAAGACAGAAAGCTAAAAAATAAAGCCTCGATGACTCCT GGTCTCCATCCTGGATCCACTCTGATTCCAATGAATAATATTTCTGTGCCGCAAGAAGAT GATTATGGGTATCAGTGTTTGGAGGGCAAAGATTGTGCCAGCTTCTTCTGTTGCTTTGAA GACTGCAGAACAGGATCTTGGAGGGAAGGAAGGATACACATACGCATTGCCAAAATTGAC TCTTATTCTAGAATATTTTTCCCAACCGCTTTTGCCCTGTTCAACTTGGTTTATTGGGTT GGCTATCTTTACTTATAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmission
name:Gamma-aminobutyric acid receptor subunit gamma-2
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
gene-name:GABRG2
locus:5q31.1-q33.1
cellular-location:Cell junction
transmembrane-regions:274-296 300-322 334-356 444-466
signal-regions:1-39
theoretical-pi:8.6
molecular-weight:54161.78
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4087GenBank Gene DatabaseX15376GenBank Protein Database31637UniProtKBP18507UniProt AccessionGBRG2_HUMAN
synonyms:GABA(A) receptor subunit gamma-2
amino-acid-sequence:>lcl|BSEQ0006917|Gamma-aminobutyric acid receptor subunit gamma-2 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
gene-sequence:>lcl|BSEQ0019445|Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) ATGAGTTCGCCAAATATATGGAGCACAGGAAGCTCAGTCTACTCGACTCCTGTATTTTCA CAGAAAATGACGGTGTGGATTCTGCTCCTGCTGTCGCTCTACCCTGGCTTCACTAGCCAG AAATCTGATGATGACTATGAAGATTATGCTTCTAACAAAACATGGGTCTTGACTCCAAAA GTTCCTGAGGGTGATGTCACTGTCATCTTAAACAACCTGCTGGAAGGATATGACAATAAA CTTCGGCCTGATATAGGAGTGAAGCCAACGTTAATTCACACAGACATGTATGTGAATAGC ATTGGTCCAGTGAACGCTATCAATATGGAATACACTATTGATATATTTTTTGCGCAAACG TGGTATGACAGACGTTTGAAATTTAACAGCACCATTAAAGTCCTCCGATTGAACAGCAAC ATGGTGGGGAAAATCTGGATTCCAGACACTTTCTTCAGAAATTCCAAAAAAGCTGATGCA CACTGGATCACCACCCCCAACAGGATGCTGAGAATTTGGAATGATGGTCGAGTGCTCTAC ACCCTAAGGTTGACAATTGATGCTGAGTGCCAATTACAATTGCACAACTTTCCAATGGAT GAACACTCCTGCCCCTTGGAGTTCTCCAGTTATGGCTATCCACGTGAAGAAATTGTTTAT CAATGGAAGCGAAGTTCTGTTGAAGTGGGCGACACAAGATCCTGGAGGCTTTATCAATTC TCATTTGTTGGTCTAAGAAATACCACCGAAGTAGTGAAGACAACTTCCGGAGATTATGTG GTCATGTCTGTCTACTTTGATCTGAGCAGAAGAATGGGATACTTTACCATCCAGACCTAT ATCCCCTGCACACTCATTGTCGTCCTATCCTGGGTGTCTTTCTGGATCAATAAGGATGCT GTTCCAGCCAGAACATCTTTAGGTATCACCACTGTCCTGACAATGACCACCCTCAGCACC ATTGCCCGGAAATCGCTCCCCAAGGTCTCCTATGTCACAGCGATGGATCTCTTTGTATCT GTTTGTTTCATCTTTGTCTTCTCTGCTCTGGTGGAGTATGGCACCTTGCATTATTTTGTC AGCAACCGGAAACCAAGCAAGGACAAAGATAAAAAGAAGAAAAACCCTGCCCCTACCATT GATATCCGCCCAAGATCAGCAACCATTCAAATGAATAATGCTACACACCTTCAAGAGAGA GATGAAGAGTACGGCTATGAGTGTCTGGACGGCAAGGACTGTGCCAGTTTTTTCTGCTGT TTTGAAGATTGTCGAACAGGAGCTTGGAGACATGGGAGGATACATATCCGCATTGCCAAA ATGGACTCCTATGCTCGGATCTTCTTCCCCACTGCCTTCTGCCTGTTTAATCTGGTCTAT TGGGTCTCCTACCTCTACCTGTGA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentaxoncomponentcell junctioncomponentchloride channel complexcomponentdendrite membranecomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionbenzodiazepine receptor activityfunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocessadult behaviorprocesscellular response to histamineprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocesspost-embryonic developmentprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesssynaptic transmission, GABAergicprocesstransmembrane transportprocesstransport
name:Gamma-aminobutyric acid receptor subunit gamma-3
general-function:Inhibitory extracellular ligand-gated ion channel activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRG3
locus:15q12
cellular-location:Cell junction
transmembrane-regions:255-277 281-303 315-337 444-467
signal-regions:1-17
theoretical-pi:7.58
molecular-weight:54288.16
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4088GenBank Gene DatabaseS82769GenBank Protein Database1754749UniProtKBQ99928UniProt AccessionGBRG3_HUMAN
synonyms:GABA(A) receptor subunit gamma-3
amino-acid-sequence:>lcl|BSEQ0006921|Gamma-aminobutyric acid receptor subunit gamma-3 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDK KLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNS NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPM DEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDY VVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLS TIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDS SRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
gene-sequence:>lcl|BSEQ0012498|Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3) ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGA AAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCA AAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAAC AGCATTGGTCCTGTGTCATCAATAAACATGGAATACCAAATTGACATATTTTTTGCTCAG ACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGC AACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAG GCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTT TACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATG GACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATT TATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAG TTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTAGGAAT TTACTGAAAGAGGCACAGCTCTCAAAAGCCAGAGAGGCCTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionGABA-A receptor activityfunctioninhibitory extracellular ligand-gated ion channel activityprocesschloride transmembrane transportprocessgamma-aminobutyric acid signaling pathwayprocession transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocessresponse to drugprocesssynaptic transmissionprocesstransmembrane transport
name:Gamma-aminobutyric acid receptor subunit pi
general-function:Gaba-a receptor activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
gene-name:GABRP
locus:5q33-q34
cellular-location:Cell junction
transmembrane-regions:243-266 270-292 305-327 417-438
signal-regions:1-16
theoretical-pi:6.99
molecular-weight:50639.735
chromosome-location:5
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:4089GenBank Gene DatabaseU95367GenBank Protein Database2197001UniProtKBO00591UniProt AccessionGBRP_HUMAN
synonyms:GABA(A) receptor subunit pi
amino-acid-sequence:>lcl|BSEQ0017152|Gamma-aminobutyric acid receptor subunit pi MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL LFPLIFMLANVFYWAYYMYF
gene-sequence:>lcl|BSEQ0017153|Gamma-aminobutyric acid receptor subunit pi (GABRP) ATGAACTACAGCCTCCACTTGGCCTTCGTGTGTCTGAGTCTCTTCACTGAGAGGATGTGC ATCCAGGGGAGTCAGTTCAACGTCGAGGTCGGCAGAAGTGACAAGCTTTCCCTGCCTGGC TTTGAGAACCTCACAGCAGGATATAACAAATTTCTCAGGCCCAATTTTGGTGGAGAACCC GTACAGATAGCGCTGACTCTGGACATTGCAAGTATCTCTAGCATTTCAGAGAGTAACATG GACTACACAGCCACCATATACCTCCGACAGCGCTGGATGGACCAGCGGCTGGTGTTTGAA GGCAACAAGAGCTTCACTCTGGATGCCCGCCTCGTGGAGTTCCTCTGGGTGCCAGATACT TACATTGTGGAGTCCAAGAAGTCCTTCCTCCATGAAGTCACTGTGGGAAACAGGCTCATC CGCCTCTTCTCCAATGGCACGGTCCTGTATGCCCTCAGAATCACGACAACTGTTGCATGT AACATGGATCTGTCTAAATACCCCATGGACACACAGACATGCAAGTTGCAGCTGGAAAGC TGGGGCTATGATGGAAATGATGTGGAGTTCACCTGGCTGAGAGGGAACGACTCTGTGCGT GGACTGGAACACCTGCGGCTTGCTCAGTACACCATAGAGCGGTATTTCACCTTAGTCACC AGATCGCAGCAGGAGACAGGAAATTACACTAGATTGGTCTTACAGTTTGAGCTTCGGAGG AATGTTCTGTATTTCATTTTGGAAACCTACGTTCCTTCCACTTTCCTGGTGGTGTTGTCC TGGGTTTCATTTTGGATCTCTCTCGATTCAGTCCCTGCAAGAACCTGCATTGGGGACAAC AAAGGAAGTAGAAGAAGTCAGTATTACTAA
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentpostsynaptic membranecomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityprocesschloride transmembrane transportprocessneurological system processprocessregulation of membrane potentialprocesssignal transductionprocesssynaptic transmission
name:Gamma-aminobutyric acid receptor subunit theta
general-function:Transmembrane signaling receptor activity
specific-function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
gene-name:GABRQ
locus:
cellular-location:Cell junction
transmembrane-regions:269-289 327-347 612-632
signal-regions:1-21
theoretical-pi:5.76
molecular-weight:72020.875
chromosome-location:X
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:14454GenBank Gene DatabaseAF189259GenBank Protein Database7861736UniProtKBQ9UN88UniProt AccessionGBRT_HUMAN
synonyms:GABA(A) receptor subunit theta
amino-acid-sequence:>lcl|BSEQ0012499|Gamma-aminobutyric acid receptor subunit theta MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQ KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRR QPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIFPT EIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFN PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY
gene-sequence:>lcl|BSEQ0012500|Gamma-aminobutyric acid receptor subunit theta (GABRQ) ATGGGCATCCGAGGCATGCTGCGAGCCGCAGTGATCCTGCTGCTCATCAGGACCTGGCTC GCGGAGGGCAACTACCCCAGTCCCATCCCGAAATTCCACTTCGAGTTCTCCTCTGCTGTG CCCGAAGTCGTCCTGAACCTCTTCAACTGCAAAAATTGTGCAAATGAAGCTGTGGTTCAA AAGATTTTGGACAGGGTGCTGTCAAGATACGATGTCCGCCTGAGACCGAATTTTGGAGGT GCCCCTGTGCCTGTGAGAATATCTATTTATGTCACGAGCATTGAACAGATCTCAGAAATG AATATGGACTACACGATCACGATGTTTTTTCATCAGACTTGGAAAGATTCACGCTTAGCA TACTATGAGACCACCCTGAACTTGACCCTGGACTATCGGATGCATGAGAAGTTGTGGGTC CCTGACTGCTACTTTCTGAACAGCAAGGATGCTTTCGTGCATGATGTGACTGTGGAGAAT CGCGTGTTTCAGCTTCACCCAGATGGAACGGTGCGGTACGGCATCCGACTCACCACTACA GCAGCTTGTTCCCTGGATCTGCATAAATTCCCTATGGACAAGCAGGCCTGCAACCTGGTG GTAGAGAGCTATGGTTACACGGTTGAAGACATCATATTATTCTGGGATGACAATGGGAAC GCCATCCACATGACTGAGGAGCTGCATATCCCTCAGTTCACTTTCCTGGGAAGGACGATT ACTAGCAAGGAGGTGTATTTCTACACAGGTTCCTACATACGCCTGATACTGAAGTTCCAG GTTCAGAGGGAAGTTAACAGCTACCTTGTGCAAGTCTACTGGCCTACTGTCCTCACCACT ATTACCTCTTGGATATCGTTTTGGATGAACTATGATTCCTCTGCAGCCAGGGTGACAATT GGCTTAACTTCAATGCTCATCCTGACCACCATCGACTCACATCTGCGGGATAAGCTCCCC AACATTTCCTGTATCAAGGCCATTGATATCTATATCCTCGTGTGCTTGTTCTTTGTGTTC CTGTCCTTGCTGGAGTATGTCTACATCAACTATCTTTTCTACAGTCGAGGACCTCGGCGC CAGCCTAGGCGACACAGGAGACCCCGAAGAGTCATTGCCCGCTACCGCTACCAGCAAGTG GTGGTAGGAAACGTGCAGGATGGCCTGATTAACGTGGAAGACGGAGTCAGCTCTCTCCCC ATCACCCCAGCGCAGGCCCCCCTGGCAAGCCCGGAAAGCCTCGGTTCTTTGACGTCCACC TCCGAGCAGGCCCAGCTGGCCACCTCGGAAAGCCTCAGCCCACTCACTTCTCTCTCAGGC CAGGCCCCCCTGGCCACTGGAGAAAGCCTGAGCGATCTCCCCTCCACCTCAGAGCAGGCC CGGCACAGCTATGGTGTTCGCTTTAATGGTTTCCAGGCTGATGACAGTATTATTCCTACC GAAATCCGCAACCGTGTCGAAGCCCATGGCCATGGTGTTACCCATGACCATGAAGATTCC AATGAGAGCTTGAGCTCGGATGAGCGCCATGGCCATGGCCCCAGTGGGAAGCCCATGCTT CACCATGGCGAGAAGGGTGTGCAAGAAGCAGGCTGGGACCTTGATGACAACAATGACAAG AGCGACTGCCTTGCCATTAAGGAGCAATTCAAGTGTGATACTAACAGTACCTGGGGCCTT AATGATGATGAGCTCATGGCCCATGGCCAAGAGAAGGACAGTAGCTCAGAGTCTGAGGAT AGTTGCCCCCCAAGCCCTGGGTGCTCCTTCACTGAAGGGTTCTCCTTCGATCTCTTTAAT CCTGACTACGTCCCAAAGGTCGACAAGTGGTCCCGGTTCCTCTTCCCTCTGGCCTTTGGG TTGTTCAACATTGTTTACTGGGTATACCATATGTATTAG
pfams:PF02931Neur_chan_LBDPF02932Neur_chan_memb
go-classifiers:componentcell junctioncomponentchloride channel complexcomponentGABA-A receptor complexcomponentintegral component of plasma membranecomponentneuron projectioncomponentplasma membranecomponentpostsynaptic membranecomponentreceptor complexcomponentsynapsefunctionchloride channel activityfunctionextracellular ligand-gated ion channel activityfunctionGABA-A receptor activityfunctionneurotransmitter transporter activityfunctiontransmembrane signaling receptor activityprocesschloride transmembrane transportprocession transmembrane transportprocessneurological system processprocessneurotransmitter transportprocessregulation of membrane potentialprocesssignal transductionprocesssynaptic transmissionprocesstransmembrane transport
载体
运输工具
药物反应
reactions:1
left-element--drugbank-id:DB00241
left-element--name:Butalbital
right-element--drugbank-id:DBMET02453
right-element--name:5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid
reactions:1
left-element--drugbank-id:DB00241
left-element--name:Butalbital
right-element--drugbank-id:DBMET02454
right-element--name:5-allyl-5-(3-hydroxy-2-methyl-1-propyl) barbituric acid
效应
不良反应