ID

DB05752||

名称

ALKS 27

描述

ALKS 27 is an inhaled formulation of trospium chloride for the treatment of chronic obstructive pulmonary disease (COPD). Study showed that ALKS 27 was well-tolerated over a wide dose range, with no dose-limited effects observed.

cas号

唯一标识码

状态

solid

组

investigational,

指示

Investigated for use/treatment in chronic obstructive pulmonary disease (COPD).

药效学

作用机制

ALKS 27 is a muscarinic receptor antagonist that relaxes smooth muscle tissue and has the potential to improve airflow in patients with chronic obstructive pulmonary disease (COPD).

毒性

代谢

吸收

半衰期

分类

消除途径

种类

盐类

蛋白质结合

清除

同义词

国际品牌

配送量

产品

混合物

包装者

生产者

价格

受影响的生物体

剂量

atc代码

fda标签

化学品安全技术说明书

专利

食物相互作用

药物相互作用

序列

实验性质

外部标识符

resource：PubChem Substance
identifier：347910212

外部链接

路径

目标

id:BE0000092
name:Muscarinic acetylcholine receptor M1
organism:Humans
known-action:unknown
name:Muscarinic acetylcholine receptor M1
general-function:Phosphatidylinositol phospholipase c activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
gene-name:CHRM1
locus:11q13
cellular-location:Cell membrane
transmembrane-regions:25-47 62-82 100-121 142-164 187-209 367-387 402-421
signal-regions:
theoretical-pi:9.67
molecular-weight:51420.375
chromosome-location:11
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1950GenAtlasCHRM1GenBank Gene DatabaseX52068GenBank Protein Database34451IUPHAR13Guide to Pharmacology13UniProtKBP11229UniProt AccessionACM1_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0000184|Muscarinic acetylcholine receptor M1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
gene-sequence:>lcl|BSEQ0009929|Muscarinic acetylcholine receptor M1 (CHRM1) ATGAACACTTCAGCCCCACCTGCTGTCAGCCCCAACATCACCGTCCTGGCACCAGGAAAG GGTCCCTGGCAAGTGGCCTTCATTGGGATCACCACGGGCCTCCTGTCGCTAGCCACAGTG ACAGGCAACCTGCTGGTACTCATCTCTTTCAAGGTCAACACGGAGCTCAAGACAGTCAAT AACTACTTCCTGCTGAGCCTGGCCTGTGCTGACCTCATCATCGGTACCTTCTCCATGAAC CTCTATACCACGTACCTGCTCATGGGCCACTGGGCTCTGGGCACGCTGGCTTGTGACCTC TGGCTGGCCCTGGACTATGTGGCCAGCAATGCCTCCGTCATGAATCTGCTGCTCATCAGC TTTGACCGCTACTTCTCCGTGACTCGGCCCCTGAGCTACCGTGCCAAGCGCACACCCCGC CGGGCAGCTCTGATGATCGGCCTGGCCTGGCTGGTTTCCTTTGTGCTCTGGGCCCCAGCC ATCCTCTTCTGGCAGTACCTGGTAGGGGAGCGGACAGTGCTAGCTGGGCAGTGCTACATC CAGTTCCTCTCCCAGCCCATCATCACCTTTGGCACAGCCATGGCTGCCTTCTACCTCCCT GTCACAGTCATGTGCACGCTCTACTGGCGCATCTACCGGGAGACAGAGAACCGAGCACGG GAGCTGGCAGCCCTTCAGGGCTCCGAGACGCCAGGCAAAGGGGGTGGCAGCAGCAGCAGC TCAGAGAGGTCTCAGCCAGGGGCTGAGGGCTCACCAGAGACTCCTCCAGGCCGCTGCTGT CGCTGCTGCCGGGCCCCCAGGCTGCTGCAGGCCTACAGCTGGAAGGAAGAAGAGGAAGAG GACGAAGGCTCCATGGAGTCCCTCACATCCTCAGAGGGAGAGGAGCCTGGCTCCGAAGTG GTGATCAAGATGCCAATGGTGGACCCCGAGGCACAGGCCCCCACCAAGCAGCCCCCACGG AGCTCCCCAAATACAGTCAAGAGGCCGACTAAGAAAGGGCGTGATCGAGCTGGCAAGGGC CAGAAGCCCCGTGGAAAGGAGCAGCTGGCCAAGCGGAAGACCTTCTCGCTGGTCAAGGAG AAGAAGGCGGCTCGGACCCTGAGTGCCATCCTCCTGGCCTTCATCCTCACCTGGACACCG TACAACATCATGGTGCTGGTGTCCACCTTCTGCAAGGACTGTGTTCCCGAGACCCTGTGG GAGCTGGGCTACTGGCTGTGCTACGTCAACAGCACCATCAACCCCATGTGCTACGCACTC TGCAACAAAGCCTTCCGGGACACCTTTCGCCTGCTGCTGCTTTGCCGCTGGGACAAGAGA CGCTGGCGCAAGATCCCCAAGCGCCCTGGCTCCGTGCACCGCACTCCCTCCCGCCAATGC TGA
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentcell junctioncomponentdendritecomponentintegral component of plasma membranecomponentmembranecomponentplasma membranecomponentpostsynaptic densitycomponentpostsynaptic membranecomponentsynapsefunctiondrug bindingfunctionG-protein coupled acetylcholine receptor activityfunctionphosphatidylinositol phospholipase C activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocesscellular protein modification processprocesscognitionprocessentrainment of circadian clockprocessG-protein coupled acetylcholine receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessnervous system developmentprocessneuromuscular synaptic transmissionprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocessphototransduction, visible lightprocesspositive regulation of cell proliferationprocesspositive regulation of intracellular protein transportprocesspositive regulation of ion transportprocessprotein kinase C-activating G-protein coupled receptor signaling pathwayprocessregulation of locomotionprocesssaliva secretionprocesssensory perception of chemical stimulusprocesssignal transductionprocesssynaptic transmission, cholinergic
id:BE0000560
name:Muscarinic acetylcholine receptor M2
organism:Humans
known-action:unknown
name:Muscarinic acetylcholine receptor M2
general-function:G-protein coupled acetylcholine receptor activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
gene-name:CHRM2
locus:7q31-q35
cellular-location:Cell membrane
transmembrane-regions:23-45 60-80 98-119 140-162 185-209 388-410 419-442
signal-regions:
theoretical-pi:9.08
molecular-weight:51714.605
chromosome-location:7
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1951GenAtlasCHRM2GenBank Gene DatabaseM16404GenBank Protein Database177990IUPHAR14Guide to Pharmacology14UniProtKBP08172UniProt AccessionACM2_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0016133|Muscarinic acetylcholine receptor M2 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
gene-sequence:>lcl|BSEQ0016134|Muscarinic acetylcholine receptor M2 (CHRM2) ATGAATAACTCAACAAACTCCTCTAACAATAGCCTGGCTCTTACAAGTCCTTATAAGACA TTTGAAGTGGTGTTTATTGTCCTGGTGGCTGGATCCCTCAGTTTGGTGACCATTATCGGG AACATCCTAGTCATGGTTTCCATTAAAGTCAACCGCCACCTCCAGACCGTCAACAATTAC TTTTTATTCAGCTTGGCCTGTGCTGACCTTATCATAGGTGTTTTCTCCATGAACTTGTAC ACCCTCTACACTGTGATTGGTTACTGGCCTTTGGGACCTGTGGTGTGTGACCTTTGGCTA GCCCTGGACTATGTGGTCAGCAATGCCTCAGTTATGAATCTGCTCATCATCAGCTTTGAC AGGTACTTCTGTGTCACAAAACCTCTGACCTACCCAGTCAAGCGGACCACAAAAATGGCA GGTATGATGATTGCAGCTGCCTGGGTCCTCTCTTTCATCCTCTGGGCTCCAGCCATTCTC TTCTGGCAGTTCATTGTAGGGGTGAGAACTGTGGAGGATGGGGAGTGCTACATTCAGTTT TTTTCCAATGCTGCTGTCACCTTTGGTACGGCTATTGCAGCCTTCTATTTGCCAGTGATC ATCATGACTGTGCTATATTGGCACATATCCCGAGCCAGCAAGAGCAGGATAAAGAAGGAC AAGAAGGAGCCTGTTGCCAACCAAGACCCCGTTTCTCCAAGTCTGGTACAAGGAAGGATA GTGAAGCCAAACAATAACAACATGCCCAGCAGTGACGATGGCCTGGAGCACAACAAAATC CAGAATGGCAAAGCCCCCAGGGATCCTGTGACTGAAAACTGTGTTCAGGGAGAGGAGAAG GAGAGCTCCAATGACTCCACCTCAGTCAGTGCTGTTGCCTCTAATATGAGAGATGATGAA ATAACCCAGGATGAAAACACAGTTTCCACTTCCCTGGGCCATTCCAAAGATGAGAACTCT AAGCAAACATGCATCAGAATTGGCACCAAGACCCCAAAAAGTGACTCATGTACCCCAACT AATACCACCGTGGAGGTAGTGGGGTCTTCAGGTCAGAATGGAGATGAAAAGCAGAATATT GTAGCCCGCAAGATTGTGAAGATGACTAAGCAGCCTGCAAAAAAGAAGCCTCCTCCTTCC CGGGAAAAGAAAGTCACCAGGACAATCTTGGCTATTCTGTTGGCTTTCATCATCACTTGG GCCCCATACAATGTCATGGTGCTCATTAACACCTTTTGTGCACCTTGCATCCCCAACACT GTGTGGACAATTGGTTACTGGCTTTGTTACATCAACAGCACTATCAACCCTGCCTGCTAT GCACTTTGCAATGCCACCTTCAAGAAGACCTTTAAACACCTTCTCATGTGTCATTATAAG AACATAGGCGCTACAAGGTAA
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentcell junctioncomponentdendritecomponentintegral component of plasma membranecomponentneuronal cell bodycomponentplasma membranecomponentpostsynaptic membranecomponentsymmetric synapsecomponentsynapsefunctiondrug bindingfunctionG-protein coupled acetylcholine receptor activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocessadenylate cyclase-modulating G-protein coupled receptor signaling pathwayprocessG-protein coupled acetylcholine receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerprocessnervous system developmentprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocessregulation of heart contractionprocessregulation of smooth muscle contractionprocessresponse to virusprocesssensory perception of chemical stimulusprocesssynaptic transmission, cholinergic
id:BE0000045
name:Muscarinic acetylcholine receptor M3
organism:Humans
known-action:unknown
name:Muscarinic acetylcholine receptor M3
general-function:Receptor activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
gene-name:CHRM3
locus:1q43
cellular-location:Cell membrane
transmembrane-regions:68-91 105-130 143-164 185-206 230-252 492-514 527-546
signal-regions:
theoretical-pi:9.62
molecular-weight:66127.445
chromosome-location:1
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1952GenAtlasCHRM3GenBank Gene DatabaseX15266GenBank Protein Database32324IUPHAR15Guide to Pharmacology15UniProtKBP20309UniProt AccessionACM3_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0009898|Muscarinic acetylcholine receptor M3 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
gene-sequence:>lcl|BSEQ0009899|Muscarinic acetylcholine receptor M3 (CHRM3) ATGACCTTGCACAATAACAGTACAACCTCGCCTTTGTTTCCAAACATCAGCTCCTCCTGG ATACACAGCCCCTCCGATGCAGGGCTGCCCCCGGGAACCGTCACTCATTTCGGCAGCTAC AATGTTTCTCGAGCAGCTGGCAATTTCTCCTCTCCAGACGGTACCACCGATGACCCTCTG GGAGGTCATACCGTCTGGCAAGTGGTCTTCATCGCTTTCTTAACGGGCATCCTGGCCTTG GTGACCATCATCGGCAACATCCTGGTAATTGTGTCATTTAAGGTCAACAAGCAGCTGAAG ACGGTCAACAACTACTTCCTCTTAAGCCTGGCCTGTGCCGATCTGATTATCGGGGTCATT TCAATGAATCTGTTTACGACCTACATCATCATGAATCGATGGGCCTTAGGGAACTTGGCC TGTGACCTCTGGCTTGCCATTGACTACGTAGCCAGCAATGCCTCTGTTATGAATCTTCTG GTCATCAGCTTTGACAGATACTTTTCCATCACGAGGCCGCTCACGTACCGAGCCAAACGA ACAACAAAGAGAGCCGGTGTGATGATCGGTCTGGCTTGGGTCATCTCCTTTGTCCTTTGG GCTCCTGCCATCTTGTTCTGGCAATACTTTGTTGGAAAGAGAACTGTGCCTCCGGGAGAG TGCTTCATTCAGTTCCTCAGTGAGCCCACCATTACTTTTGGCACAGCCATCGCTGCTTTT TATATGCCTGTCACCATTATGACTATTTTATACTGGAGGATCTATAAGGAAACTGAAAAG CGTACCAAAGAGCTTGCTGGCCTGCAAGCCTCTGGGACAGAGGCAGAGACAGAAAACTTT GTCCACCCCACGGGCAGTTCTCGAAGCTGCAGCAGTTACGAACTTCAACAGCAAAGCATG AAACGCTCCAACAGGAGGAAGTATGGCCGCTGCCACTTCTGGTTCACAACCAAGAGCTGG AAACCCAGCTCCGAGCAGATGGACCAAGACCACAGCAGCAGTGACAGTTGGAACAACAAT GATGCTGCTGCCTCCCTGGAGAACTCCGCCTCCTCCGACGAGGAGGACATTGGCTCCGAG ACGAGAGCCATCTACTCCATCGTGCTCAAGCTTCCGGGTCACAGCACCATCCTCAACTCC ACCAAGTTACCCTCATCGGACAACCTGCAGGTGCCTGAGGAGGAGCTGGGGATGGTGGAC TTGGAGAGGAAAGCCGACAAGCTGCAGGCCCAGAAGAGCGTGGACGATGGAGGCAGTTTT CCAAAAAGCTTCTCCAAGCTTCCCATCCAGCTAGAGTCAGCCGTGGACACAGCTAAGACT TCTGACGTCAACTCCTCAGTGGGTAAGAGCACGGCCACTCTACCTCTGTCCTTCAAGGAA GCCACTCTGGCCAAGAGGTTTGCTCTGAAGACCAGAAGTCAGATCACTAAGCGGAAAAGG ATGTCCCTGGTCAAGGAGAAGAAAGCGGCCCAGACCCTCAGTGCGATCTTGCTTGCCTTC ATCATCACTTGGACCCCATACAACATCATGGTTCTGGTGAACACCTTTTGTGACAGCTGC ATACCCAAAACCTTTTGGAATCTGGGCTACTGGCTGTGCTACATCAACAGCACCGTGAAC CCCGTGTGCTATGCTCTGTGCAACAAAACATTCAGAACCACTTTCAAGATGCTGCTGCTG TGCCAGTGTGACAAAAAAAAGAGGCGCAAGCAGCAGTACCAGCAGAGACAGTCGGTCATT TTTCACAAGCGCGCACCCGAGCAGGCCTTGTAG
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentbasolateral plasma membranecomponentcell junctioncomponentdendritecomponentintegral component of plasma membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionacetylcholine bindingfunctiondrug bindingfunctionG-protein coupled acetylcholine receptor activityfunctionphosphatidylinositol phospholipase C activityfunctionreceptor activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocesscellular protein modification processprocessenergy reserve metabolic processprocessG-protein coupled acetylcholine receptor signaling pathwayprocessG-protein coupled receptor signaling pathwayprocessnervous system developmentprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocesspositive regulation of smooth muscle contractionprocessregulation of insulin secretionprocessregulation of vascular smooth muscle contractionprocesssaliva secretionprocesssensory perception of chemical stimulusprocesssignal transductionprocesssmall molecule metabolic processprocesssmooth muscle contractionprocesssynaptic transmission, cholinergic
id:BE0000405
name:Muscarinic acetylcholine receptor M4
organism:Humans
known-action:unknown
name:Muscarinic acetylcholine receptor M4
general-function:Guanyl-nucleotide exchange factor activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
gene-name:CHRM4
locus:11p12-p11.2
cellular-location:Cell membrane
transmembrane-regions:32-54 69-89 107-128 149-171 194-216 402-422 437-456
signal-regions:
theoretical-pi:10.34
molecular-weight:53048.65
chromosome-location:11
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1953GenAtlasCHRM4GenBank Gene DatabaseM16405GenBank Protein Database61970253IUPHAR16Guide to Pharmacology16UniProtKBP08173UniProt AccessionACM4_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0010280|Muscarinic acetylcholine receptor M4 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
gene-sequence:>lcl|BSEQ0010281|Muscarinic acetylcholine receptor M4 (CHRM4) ATGGCCAACTTCACACCTGTCAATGGCAGCTCGGGCAATCAGTCCGTGCGCCTGGTCACG TCATCATCCCACAATCGCTATGAGACGGTGGAAATGGTCTTCATTGCCACAGTGACAGGC TCCCTGAGCCTGGTGACTGTCGTGGGCAACATCCTGGTGATGCTGTCCATCAAGGTCAAC AGGCAGCTGCAGACAGTCAACAACTACTTCCTCTTCAGCCTGGCGTGTGCTGATCTCATC ATAGGCGCCTTCTCCATGAACCTCTACACCGTGTACATCATCAAGGGCTACTGGCCCCTG GGCGCCGTGGTCTGCGACCTGTGGCTGGCCCTGGACTACGTGGTGAGCAACGCCTCCGTC ATGAACCTTCTCATCATCAGCTTTGACCGCTACTTCTGCGTCACCAAGCCTCTCACCTAC CCTGCCCGGCGCACCACCAAGATGGCAGGCCTCATGATTGCTGCTGCCTGGGTACTGTCC TTCGTGCTCTGGGCGCCTGCCATCTTGTTCTGGCAGTTTGTGGTGGGTAAGCGGACGGTG CCCGACAACCAGTGCTTCATCCAGTTCCTGTCCAACCCAGCAGTGACCTTTGGCACAGCC ATTGCTGCCTTCTACCTGCCTGTGGTCATCATGACGGTGCTGTACATCCACATCTCCCTG GCCAGTCGCAGCCGAGTCCACAAGCACCGGCCCGAGGGCCCGAAGGAGAAGAAAGCCAAG ACGCTGGCCTTCCTCAAGAGCCCACTAATGAAGCAGAGCGTCAAGAAGCCCCCGCCCGGG GAGGCCGCCCGGGAGGAGCTGCGCAATGGCAAGCTGGAGGAGGCCCCCCCGCCAGCGCTG CCACCGCCACCGCGCCCCGTGGCTGATAAGGACACTTCCAATGAGTCCAGCTCAGGCAGT GCCACCCAGAACACCAAGGAACGCCCAGCCACAGAGCTGTCCACCACAGAGGCCACCACG CCCGCCATGCCCGCCCCTCCCCTGCAGCCGCGGGCCCTCAACCCAGCCTCCAGATGGTCC AAGATCCAGATTGTGACGAAGCAGACAGGCAATGAGTGTGTGACAGCCATTGAGATTGTG CCTGCCACGCCGGCTGGCATGCGCCCTGCGGCCAACGTGGCCCGCAAGTTCGCCAGCATC GCTCGCAACCAGGTGCGCAAGAAGCGGCAGATGGCGGCCCGGGAGCGCAAAGTGACACGA ACGATCTTTGCCATTCTGCTAGCCTTCATCCTCACCTGGACGCCCTACAACGTCATGGTC CTGGTGAACACCTTCTGCCAGAGCTGCATCCCTGACACGGTGTGGTCCATTGGCTACTGG CTCTGCTACGTCAACAGCACCATCAACCCTGCCTGCTATGCTCTGTGCAACGCCACCTTT AAAAAGACCTTCCGGCACCTGCTGCTGTGCCAGTATCGGAACATCGGCACTGCCAGGTAG
pfams:PF000017tm_1
go-classifiers:componentasymmetric synapsecomponentaxon terminuscomponentcell junctioncomponentcytoplasmcomponentintegral component of plasma membranecomponentneuronal cell bodycomponentplasma membranecomponentpostsynaptic densitycomponentpostsynaptic membranecomponentsarcolemmacomponentsynapsefunctionG-protein coupled acetylcholine receptor activityfunctionguanyl-nucleotide exchange factor activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocesscell surface receptor signaling pathwayprocessG-protein coupled acetylcholine receptor signaling pathwayprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocessregulation of locomotionprocessresponse to organic substanceprocesssensory perception of chemical stimulusprocesssignal transductionprocesssynaptic transmission, cholinergic
id:BE0000247
name:Muscarinic acetylcholine receptor M5
organism:Humans
known-action:unknown
name:Muscarinic acetylcholine receptor M5
general-function:Phosphatidylinositol phospholipase c activity
specific-function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
gene-name:CHRM5
locus:15q26
cellular-location:Cell membrane
transmembrane-regions:30-53 67-87 105-126 147-169 192-214 444-464 479-498
signal-regions:
theoretical-pi:9.64
molecular-weight:60073.205
chromosome-location:15
organism:Humans
external-identifiers:HUGO Gene Nomenclature Committee (HGNC)HGNC:1954GenAtlasCHRM5GenBank Gene DatabaseM80333GenBank Protein Database177988IUPHAR17Guide to Pharmacology17UniProtKBP08912UniProt AccessionACM5_HUMAN
synonyms:
amino-acid-sequence:>lcl|BSEQ0010217|Muscarinic acetylcholine receptor M5 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
gene-sequence:>lcl|BSEQ0010218|Muscarinic acetylcholine receptor M5 (CHRM5) ATGGAAGGGGATTCTTACCACAATGCAACCACCGTCAATGGCACCCCAGTAAATCACCAG CCTTTGGAACGCCACAGGTTGTGGGAAGTCATCACCATTGCAGCTGTGACTGCTGTGGTA AGCCTGATCACCATTGTGGGCAATGTCTTGGTCATGATCTCCTTCAAAGTCAACAGCCAG CTCAAGACAGTTAACAACTATTACCTGCTCAGCTTAGCCTGTGCAGATCTCATCATTGGA ATCTTCTCCATGAACCTCTACACCACCTACATCCTCATGGGACGCTGGGCTCTCGGGAGT CTGGCTTGTGACCTTTGGCTTGCACTGGACTACGTGGCCAGCAACGCTTCTGTCATGAAC CTTCTGGTGATCAGTTTTGACCGTTACTTTTCCATCACAAGACCCTTGACATATCGGGCC AAGCGTACTCCGAAAAGGGCTGGCATCATGATTGGCTTGGCCTGGCTGATCTCCTTCATC CTCTGGGCCCCAGCAATCCTCTGCTGGCAGTACTTGGTTGGGAAGCGGACAGTTCCACTG GATGAGTGCCAGATCCAGTTTCTCTCTGAGCCCACCATCACTTTTGGCACTGCCATTGCT GCCTTCTACATCCCTGTTTCTGTCATGACCATCCTCTACTGTCGAATCTACCGGGAAACA GAGAAGCGAACCAAGGACCTGGCTGACCTCCAGGGTTCTGACTCTGTGACCAAAGCTGAG AAGAGAAAGCCAGCTCATAGGGCTCTGTTCAGATCCTGCTTGCGCTGTCCTCGACCCACC CTGGCCCAGCGGGAAAGGAACCAGGCCTCCTGGTCATCCTCCCGCAGGAGCACCTCCACC ACTGGGAAGCCATCCCAAGCCACTGGCCCAAGCGCCAATTGGGCCAAAGCTGAGCAGCTC ACCACCTGTAGCAGCTACCCTTCCTCAGAGGATGAGGACAAGCCCGCCACTGACCCTGTC CTCCAAGTGGTCTACAAGAGTCAGGGTAAGGAAAGCCCAGGGGAAGAATTCAGTGCTGAA GAGACTGAGGAAACTTTTGTGAAAGCTGAAACTGAAAAAAGTGACTATGACACCCCAAAC TACCTTCTGTCTCCAGCAGCTGCTCATAGACCCAAGAGTCAGAAATGTGTGGCCTATAAG TTCCGATTGGTGGTAAAAGCTGACGGGAACCAGGAGACCAACAATGGCTGTCACAAGGTG AAAATCATGCCCTGCCCCTTCCCAGTGGCCAAGGAACCTTCAACGAAAGGCCTCAATCCC AACCCCAGCCATCAAATGACCAAACGAAAGAGAGTGGTCCTAGTCAAAGAGAGGAAAGCA GCCCAGACACTGAGTGCCATTCTCCTGGCCTTCATCATCACATGGACCCCGTATAACATC ATGGTCCTGGTTTCTACCTTCTGTGACAAGTGTGTCCCAGTCACCCTGTGGCACTTGGGC TATTGGTTGTGCTATGTCAATAGCACTGTCAACCCCATCTGCTATGCCCTCTGCAACAGA ACCTTCAGGAAGACCTTTAAGATGCTGCTTCTCTGCCGATGGAAAAAGAAAAAAGTGGAA GAGAAGTTGTACTGGCAGGGGAACAGCAAGCTACCCTGA
pfams:PF000017tm_1
go-classifiers:componentcell junctioncomponentintegral component of plasma membranecomponentplasma membranecomponentpostsynaptic membranecomponentsynapsefunctionG-protein coupled acetylcholine receptor activityfunctionphosphatidylinositol phospholipase C activityprocessadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayprocesscell proliferationprocessdopamine transportprocessG-protein coupled acetylcholine receptor signaling pathwayprocessgastric acid secretionprocessphospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayprocessregulation of phosphatidylinositol dephosphorylationprocesssensory perception of chemical stimulusprocesssynaptic transmission, cholinergicprocesstransmission of nerve impulse

酶

载体

运输工具

药物反应

效应

不良反应