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		1 The Evolving Drug Discovery and Development Process



		John C. Somberg Finch University of Health Sciences/The Chicago Medical School North Chicago, Illinois



		I. Introduction



		2



		II. The Age of Botanicals



		3



		III. Chemical Synthetic Discovery



		6



		IV. Biotechnology and Gene Manipulation



		8



		V. Gene Therapy



		10



		VI. The Developers



		11



		VII. Small Development Companies



		11



		VIII. Academicians and Entrepreneurs



		12



		IX. The Government and Drug Development



		14



		X. Government Research



		15



		XI. The Fda Regulators



		16



		XII. Issues and Concepts in Drug Development



		19



		XIII. Pharmaceutical Structure



		21

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