| Table 3 Continued |
| Excipient | | |
| Mannitol (cont.) | Noncariogenic | |
| Low caloric value | |
|  |
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Good mouth feel, free of grittiness, sweet cooling taste |
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| |
| Sorbitol | Highly compressible | Very hygroscopic |
| High solubility | |
| White | |
| Noncariogenic | |
| |
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Good mouth feel, free of grittiness, sweet cooling taste |
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| |
| Dextrose | Water soluble | Produces soft tablet |
| Some binding action | On aging, disintegration time increases hardness increases, friability decreases |
| |
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Less hygroscopic than lactose |
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| |
| |
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Can be dried to low moisture content |
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| |
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More browning of tablets in the presence of amines than with lactose |
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|
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|
| Dextrates | Water soluble | Reactive with amines |
| Nonhygroscopic | |
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|
|
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Contains 810% moisture |
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| Free flowing | |
| Rapid dissolution | |
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Tablet hardness may increase after compression |
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| |
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|
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Good mouth feel, free of grittiness, sweet cooling taste |
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| |
| Starch* | Inert | |
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Contains up to 10% moisture |
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| Disintegrant activity | |
| Some lubricant action | |
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Dried granulations can absorb moisture |
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| Good oil absorption properties | |
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Produces a soft tablet |
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| Pregelatinized Starch | Good binder | |
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Needs high pressures to produce a hard tablet |
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| Free flowing | |
| High dilution capacity | |
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Binding properties reduced by lubricants; tends to soften when used with magnesium stearate |
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| Excellent carrier for incorporating dye systems in tablet granulations | |
| Self-lubricating | |
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For good flow, a glidant is required |
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| Disintegrant activity | |
| *Wet granulation as capsule-filler material |