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Fig. 4
Effect of particle size of penicillin G procaine administered in
aqueous suspension (IM 300K U/mL) on the serum level in rabbits. |
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area; however, in some vehicles, there is a hydrophobic protecting layer, and the absorption may be retarded, if very small particles are present (Fig. 4). |
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In ointments and suppositories (semisolid heterogeneous systems) the particle size of the undissolved portion of the drug plays a significant role in achieving the desired effect. In these cases, by decreasing the particle size, an increase in the solubility and the quantity of the drug absorbed is observed. The optimal particle size should be determined in the course of drug formulation experimentation. |
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Based on observations of numerous experimental data, it may be inferred that the differences in the therapeutic effect of different drug products that contain the same active ingredient are most frequently the result of differences |
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