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system can be switched on by external light of characteristic wavelength, which results in the formation of singlet oxygen that destroys the cell [253255]. |
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Iontophoresis uses an electric vield to increase the permeation of drugs delivered transdermallfy [256,257]. Permeation is proportional to the electric current. Therefore, pulsatile delivery can be obtained by an on-off switch in the circuitry, allowing electric current across the device [258]. Iontophoresis is further advanced than any of the other technologies mentioned above and several human clinical trials have been performed with, for example, nanopeptide leuprolide [259] and fentanyl and morphine for patient-controlled post-operative analgesia [259,260]. |
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1983. |
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