< previous page	page_219	next page >
Page 219 8 New Approaches to Nonclinical Biodisposition Studies D. Bruce Campbell Servier Research and Development Ltd. Fulmer, Slough, England I. Introduction 220 II. Discovery 221 A. Expert Systems 222 III. In Vitro Metabolism 225 IV. Metabolic Isoforms and Kinetic Variability 226 V. Scaling 229 A. In Vitro Scaling 230 B. In Vivo Scaling 232 VI. Are All Preclinical ADME Studies Necessary? 235 VII. Blood Levels and Effect 239 A. Receptor-Based Models 241 B. Physiological Systems Modeling 241 C. Neural Networks 245 VIII. Tissue Uptake 246 A. Microdialysis 247 B. Imaging 247
< previous page	page_219	next page >