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Fig. 5 Relationship between in vivo clearance in (a) rats compared with in vitro hepatic
microsomal clearance with a line representing a 500 mg microsomal protein
standard rat-scaling factor (from Ref. 41), (b) humans compared with that
predicted from rat in vivo clearance using a maximum life potential (MLP)
allometric scaling with the line of identity (from Ref. 48). |
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