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Fig. 6
Survey of the extent of nonclinical kinetics undertaken by companies in Europe,
USA, and Japan before Phase I: sd = single dose, md = multiple dose, met =
metabolism, balan = radioactive balance studies, induct = induction,
inhibit = inhibition, enter circ = enterohepatic recirculation, distrib = distribution,
spec anim = special animals, pb = species binding, can = cannulation,
wba = whole body autoradiography. (From Ref. 58.) |
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