DISEASE: Hepatitis B


Entry
H00412                      Disease                                
Name
Hepatitis B;
Hepatitis B virus (HBV) infection
  Supergrp
Viral hepatitis [DS:H02162]
Fulminant hepatic failure [DS:H01712]
Description
Hepatitis B is an infectious disease caused by hepatitis B virus (HBV) belonging to the Hepadnaviridae family of dsDNA-RT viruses. Both acute and chronic hepatitis B can be caused by blood-borne HBV infections. The risk of developing chronic hepatitis B is directly related to the age of first infection, much higher for infants. Chronic hepatitis B may eventaully lead to cirrhosis and hepatocellular carcinoma.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA-RT viruses
   H00412  Hepatitis B
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Viral hepatitis
   1E50  Acute viral hepatitis
    H00412  Hepatitis B
   1E51  Chronic viral hepatitis
    H00412  Hepatitis B
Pathway
hsa05161  Hepatitis B
Network
nt06162  Hepatitis B virus (HBV)
Gene
IFNAR2 (susceptibility) [HSA:3455] [KO:K05131]
IFNGR1 (susceptibility) [HSA:3459] [KO:K05132]
IL10RB (susceptibility) [HSA:3588] [KO:K05135]
Pathogen
Hepatitis B virus (HBV) [GN:T40004]
Drug
Lamivudine [DR:D00353]
Tenofovir disoproxil fumarate [DR:D01982]
Adefovir dipivoxil [DR:D01655]
Entecavir [DR:D04008]
Telbivudine [DR:D06675]
Tenofovir alafenamide fumarate [DR:D10605]
Hepatitis B immune globulin [DR:D04431]
Interferon alfa-2b [DR:D02745]
Peginterferon alfa-2a [DR:D02747]
Other DBs
ICD-11: 1E50.1 1E51.0
ICD-10: B16
MeSH: D006509
MedlinePlus: 000279
OMIM: 610424
Reference
PMID:22252919
  Authors
Nebbia G, Peppa D, Maini MK
  Title
Hepatitis B infection: current concepts and future challenges.
  Journal
QJM 105:109-13 (2012)
DOI:10.1093/qjmed/hcr270
Reference
PMID:12000599
  Authors
Pramoolsinsup C
  Title
Management of viral hepatitis B.
  Journal
J Gastroenterol Hepatol 17 Suppl:S125-45 (2002)
DOI:10.1046/j.1440-1746.17.s1.3.x
Reference
PMID:22171125
  Authors
Tan YJ
  Title
Hepatitis B virus infection and the risk of hepatocellular carcinoma.
  Journal
World J Gastroenterol 17:4853-7 (2011)
DOI:10.3748/wjg.v17.i44.4853
Reference
PMID:16757563 (IFNAR2, IL10RB)
  Authors
Frodsham AJ, Zhang L, Dumpis U, Taib NA, Best S, Durham A, Hennig BJ, Hellier S, Knapp S, Wright M, Chiaramonte M, Bell JI, Graves M, Whittle HC, Thomas HC, Thursz MR, Hill AV
  Title
Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
  Journal
Proc Natl Acad Sci U S A 103:9148-53 (2006)
DOI:10.1073/pnas.0602800103
Reference
PMID:19488747 (IFNGR1)
  Authors
Zhou J, Chen DQ, Poon VK, Zeng Y, Ng F, Lu L, Huang JD, Yuen KY, Zheng BJ
  Title
A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.
  Journal
Immunogenetics 61:423-30 (2009)
DOI:10.1007/s00251-009-0377-8

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