Entry

H00304                      Disease

Name

Haemophilus influenzae infection

Description

Haemophilus influenzae type b (Hib) infections are a major cause of severe infections in children between 2 months and 5 years of age worldwide. It affects approximately 25000 patients each year. Severity of the symptoms of Hib infection depends on the patient's age, and infants between 4 months and 1 year of age are at highest risk for meningitis. Invasive disease due to Hib may produce various clinical syndromes including meningitis, arthritis, pneumonia, cellulitis, osteomyelitis, and epiglottitis. Mucosal infections, such as bronchitis, sinusitis and conjunctivitis, and otitis media, can also be caused by Hib, but they are considered to be noninvasive disease.

Category

Infectious disease

Brite

Infectious diseases [BR:br08401]
Bacterial infections
  Infections caused by other gamma proteobacteria
   H00304  Haemophilus influenzae infection
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
  Non-viral and unspecified infections of the central nervous system
   1D01  Infectious meningitis not elsewhere classified
    H00304  Haemophilus influenzae infection
12 Diseases of the respiratory system
  Lung infections
   CA40  Pneumonia
    H00304  Haemophilus influenzae infection
   CA42  Acute bronchitis
    H00304  Haemophilus influenzae infection

Pathogen

Haemophilus influenzae [GN:hin hit hip hiq hiu hik hih]

Comment

American Indians and Alaskan Eskimos are at increased risk specifically for meningitis caused by Hib.

Other DBs

ICD-11:

1D01.00 CA40.02 CA42.4

ICD-10:

A41.3 A49.2 G00.0 J14 J20.1

MeSH:

D006192

Reference

PMID:2194406

Authors

Janai H, Stutman HR, Marks MI

Title

Invasive Haemophilus influenzae type B infections: a continuing challenge.

Journal

Am J Infect Control 18:160-6 (1990)
DOI:10.1016/0196-6553(90)90181-Q

Reference

PMID:22244051

Authors

Ladhani SN

Title

Two decades of experience with the Haemophilus influenzae serotype b conjugate vaccine in the United Kingdom.

Journal

Clin Ther 34:385-99 (2012)
DOI:10.1016/j.clinthera.2011.11.027

Reference

PMID:20980793

Authors

Fitzwater SP, Watt JP, Levine OS, Santosham M

Title

Haemophilus influenzae type b conjugate vaccines: considerations for vaccination schedules and implications for developing countries.

Journal

Hum Vaccin 6:810-8 (2010)
DOI:10.4161/hv.6.10.13017

Reference

PMID:3325012

Authors

Gilbert GL

Title

Epidemiology and prevention of invasive Haemophilus influenzae type b infection.

Journal

Aust Paediatr J 23:323-7 (1987)
DOI:10.1111/j.1440-1754.1987.tb00283.x

DISEASE: Haemophilus influenzae infection