Entry

H00313                      Disease

Name

Multidrug-resistant Pseudomonas aeruginosa infection

Description

Pseudomonas aeruginosa is an opportunistic pathogen that may cause severe invasive diseases in critically ill patients. In the 21st century, when the life expectancy of highly susceptible immunocompromised groups has been extended in most countries, P. aeruginosa plays an increasingly prominent role in hospital infections. This organism shows a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive expression of beta-lactamases and efflux pumps, combined with low permeability of the outer-membrane) or following acquisition of resistance genes (e.g., genes for beta-lactamases, or enzymes inactivating aminoglycosides or modifying their target), over-expression of efflux pumps, decreased expression of porins, or mutations in quinolone targets. These mechanisms mediate the multidrug-resistant (MDR) phenotype in P. aeruginosa.

Category

Infectious disease

Brite

Infectious diseases [BR:br08401]
Bacterial infections
  Infections caused by other gamma proteobacteria
   H00313  Multidrug-resistant Pseudomonas aeruginosa infection
Human diseases in ICD-11 classification [BR:br08403]
21 Symptoms, signs or clinical findings, not elsewhere classified
  General symptoms, signs or clinical findings
   Finding of microorganism resistant to antimicrobial drugs
    MG50  Finding of gram negative bacteria resistant to antimicrobial drugs
     H00313  Multidrug-resistant Pseudomonas aeruginosa infection

Pathogen

Pseudomonas aeruginosa [GN:pap pnc prp]

Comment

P. aeruginosa genes containing mutations:
nalC [KO:K18130]
nalD [KO:K18135]

Other DBs

ICD-11:

MG50.8

ICD-10:

A49.8 J15.1

MeSH:

D011552

Reference

PMID:20715920

Authors

Hirsch EB, Tam VH

Title

Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes.

Journal

Expert Rev Pharmacoecon Outcomes Res 10:441-51 (2010)
DOI:10.1586/erp.10.49

Reference

PMID:17266725

Authors

Mesaros N, Nordmann P, Plesiat P, Roussel-Delvallez M, Van Eldere J, Glupczynski Y, Van Laethem Y, Jacobs F, Lebecque P, Malfroot A, Tulkens PM, Van Bambeke F

Title

Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.

Journal

Clin Microbiol Infect 13:560-78 (2007)
DOI:10.1111/j.1469-0691.2007.01681.x

Reference

PMID:24409175

Authors

Morita Y, Tomida J, Kawamura Y

Title

Responses of Pseudomonas aeruginosa to antimicrobials.

Journal

Front Microbiol 4:422 (2014)
DOI:10.3389/fmicb.2013.00422

Reference

PMID:20107499

Authors

Roy PH, Tetu SG, Larouche A, Elbourne L, Tremblay S, Ren Q, Dodson R, Harkins D, Shay R, Watkins K, Mahamoud Y, Paulsen IT

Title

Complete genome sequence of the multiresistant taxonomic outlier Pseudomonas aeruginosa PA7.

Journal

PLoS One 5:e8842 (2010)
DOI:10.1371/journal.pone.0008842

Reference

PMID:22123763

Authors

Miyoshi-Akiyama T, Kuwahara T, Tada T, Kitao T, Kirikae T

Title

Complete genome sequence of highly multidrug-resistant Pseudomonas aeruginosa NCGM2.S1, a representative strain of a cluster endemic to Japan.

Journal

J Bacteriol 193:7010 (2011)
DOI:10.1128/JB.06312-11

Reference

PMID:23908295

Authors

Jeukens J, Boyle B, Bianconi I, Kukavica-Ibrulj I, Tummler B, Bragonzi A, Levesque RC

Title

Complete Genome Sequence of Persistent Cystic Fibrosis Isolate Pseudomonas aeruginosa Strain RP73.

Journal

Genome Announc 1:e00568-13 (2013)
DOI:10.1128/genomeA.00568-13

Reference

PMID:25070493

Authors

Nakamura I, Yamaguchi T, Tsukimori A, Sato A, Fukushima S, Matsumoto T

Title

New options of antibiotic combination therapy for multidrug-resistant Pseudomonas aeruginosa.

Journal

Eur J Clin Microbiol Infect Dis 34:83-7 (2015)
DOI:10.1007/s10096-014-2192-x

Reference

PMID:16641429

Authors

Quale J, Bratu S, Gupta J, Landman D

Title

Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates.

Journal

Antimicrob Agents Chemother 50:1633-41 (2006)
DOI:10.1128/AAC.50.5.1633-1641.2006

DISEASE: Multidrug-resistant Pseudomonas aeruginosa infection